http://togogenome.org/gene/13616:LOC100028882 ^@ http://purl.uniprot.org/uniprot/F7AL73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PSMA5 ^@ http://purl.uniprot.org/uniprot/F6QW93 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:DDX55 ^@ http://purl.uniprot.org/uniprot/F6Q001 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:CFAP52 ^@ http://purl.uniprot.org/uniprot/F7EJN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP52 family.|||cilium axoneme|||flagellum http://togogenome.org/gene/13616:FADS6 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCJ0 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/13616:RNF2 ^@ http://purl.uniprot.org/uniprot/F7EE54 ^@ Subcellular Location Annotation ^@ Chromosome|||Cytoplasm http://togogenome.org/gene/13616:HTR1B ^@ http://purl.uniprot.org/uniprot/F6T6U1 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity. Arrestin family members inhibit signaling via G proteins and mediate activation of alternative signaling pathways. Regulates the release of 5-hydroxytryptamine, dopamine and acetylcholine in the brain, and thereby affects neural activity, nociceptive processing, pain perception, mood and behavior. Besides, plays a role in vasoconstriction of cerebral arteries.|||Homodimer. Heterodimer with HTR1D.|||Ligands are bound in a hydrophobic pocket formed by the transmembrane helices.|||Membrane|||Palmitoylated.|||Phosphorylated. http://togogenome.org/gene/13616:HMGB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/13616:MTMR12 ^@ http://purl.uniprot.org/uniprot/F7BDM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Sarcoplasmic reticulum|||sarcomere http://togogenome.org/gene/13616:NUBP1 ^@ http://purl.uniprot.org/uniprot/F7GH42 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Cell projection|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Implicated in the regulation of centrosome duplication.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1. http://togogenome.org/gene/13616:NRG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9D3|||http://purl.uniprot.org/uniprot/F7CPL9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted http://togogenome.org/gene/13616:CCND3 ^@ http://purl.uniprot.org/uniprot/F7EFT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SLC26A8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAV4|||http://purl.uniprot.org/uniprot/A0A5F8GQG5|||http://purl.uniprot.org/uniprot/A0A5F8HAL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/13616:MOGAT2 ^@ http://purl.uniprot.org/uniprot/F7BUD7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPL35 ^@ http://purl.uniprot.org/uniprot/F6WN79 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/13616:MCTP2 ^@ http://purl.uniprot.org/uniprot/F7C9M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CLCN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/13616:PXMP2 ^@ http://purl.uniprot.org/uniprot/F7BWJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/13616:KIAA0922 ^@ http://purl.uniprot.org/uniprot/F6UU98 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/13616:CCL19 ^@ http://purl.uniprot.org/uniprot/F6QYE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:CREG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H079 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/13616:WDR82 ^@ http://purl.uniprot.org/uniprot/F6UGV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/13616:WNT5A ^@ http://purl.uniprot.org/uniprot/F6XUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:AOX2 ^@ http://purl.uniprot.org/uniprot/F7CG46 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/13616:EFHB ^@ http://purl.uniprot.org/uniprot/A0A5F8GBM0|||http://purl.uniprot.org/uniprot/F7G6S0 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/13616:RNF146 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJU6 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/13616:FTHL17 ^@ http://purl.uniprot.org/uniprot/F6QWX8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/13616:CDA ^@ http://purl.uniprot.org/uniprot/F7FRF9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/13616:SSX2IP ^@ http://purl.uniprot.org/uniprot/F6QME7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/13616:NR4A2 ^@ http://purl.uniprot.org/uniprot/F6SX93 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family.|||Cytoplasm|||Interacts with SFPQ, NCOR2, SIN3A and HADC1. The interaction with NCOR2 increases in the absence of PITX3. Interacts with PER2.|||Nucleus http://togogenome.org/gene/13616:LOC103099394 ^@ http://purl.uniprot.org/uniprot/F7E8E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100021803 ^@ http://purl.uniprot.org/uniprot/F6YQL0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:BRIX1 ^@ http://purl.uniprot.org/uniprot/F7C078 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/13616:RPL30 ^@ http://purl.uniprot.org/uniprot/F6PGS6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/13616:OTUD7A ^@ http://purl.uniprot.org/uniprot/F7FSS6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MRPS12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIA4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/13616:OPRM1 ^@ http://purl.uniprot.org/uniprot/F7CDR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/13616:INTS7 ^@ http://purl.uniprot.org/uniprot/K7E250 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/13616:T2R62 ^@ http://purl.uniprot.org/uniprot/Q2AB84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:UBA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G327|||http://purl.uniprot.org/uniprot/A0A5F8G4W2|||http://purl.uniprot.org/uniprot/F7BMV0 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/13616:RPL37A ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ95 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/13616:PDF ^@ http://purl.uniprot.org/uniprot/F6YGB7 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/13616:MMP23B ^@ http://purl.uniprot.org/uniprot/F7CDE4 ^@ Caution|||Similarity ^@ Belongs to the peptidase M10A family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/F7C5A4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/13616:CHST11 ^@ http://purl.uniprot.org/uniprot/F6UG44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:S1PR2 ^@ http://purl.uniprot.org/uniprot/K7E3K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:LOC100012925 ^@ http://purl.uniprot.org/uniprot/F6TUB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/13616:IFRD1 ^@ http://purl.uniprot.org/uniprot/F6ZRD1 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/13616:GRAP ^@ http://purl.uniprot.org/uniprot/A0A5F8G8D8|||http://purl.uniprot.org/uniprot/A0A5F8GEC9 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/13616:NMS ^@ http://purl.uniprot.org/uniprot/A0A5F8G662 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/13616:TM7SF3 ^@ http://purl.uniprot.org/uniprot/F6YNC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CIRBP ^@ http://purl.uniprot.org/uniprot/F7E6M5 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with EIF4G1. Associates with ribosomes.|||nucleoplasm http://togogenome.org/gene/13616:BAIAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6Q9|||http://purl.uniprot.org/uniprot/A0A5F8GJA3|||http://purl.uniprot.org/uniprot/F7B8V7 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/13616:ADAMTS15 ^@ http://purl.uniprot.org/uniprot/F7E8C6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:PPIE ^@ http://purl.uniprot.org/uniprot/F6YJW7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIase E subfamily.|||Catalyzes the cis-trans isomerization of proline imidic peptide bonds in proteins. http://togogenome.org/gene/13616:GLRX ^@ http://purl.uniprot.org/uniprot/A0A5F8HC20 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/13616:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/F7D704 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/13616:NNMT ^@ http://purl.uniprot.org/uniprot/F6SV98 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/13616:METAP1D ^@ http://purl.uniprot.org/uniprot/A0A5F8HDU5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/13616:SFMBT1 ^@ http://purl.uniprot.org/uniprot/F7CIK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CNOT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXH6|||http://purl.uniprot.org/uniprot/F7C073 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/13616:FAM63B ^@ http://purl.uniprot.org/uniprot/F6RGW0 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/13616:DGAT2 ^@ http://purl.uniprot.org/uniprot/F7CDB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:B4GALT7 ^@ http://purl.uniprot.org/uniprot/F6TER0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:ACTL10 ^@ http://purl.uniprot.org/uniprot/F6Q4H1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:GADD45B ^@ http://purl.uniprot.org/uniprot/F6U5E4 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/13616:MST1 ^@ http://purl.uniprot.org/uniprot/F7G1K1 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:IRX6 ^@ http://purl.uniprot.org/uniprot/F6Z3M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/13616:PODXL ^@ http://purl.uniprot.org/uniprot/K7E166 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the podocalyxin family.|||Cell membrane|||Involved in the regulation of both adhesion and cell morphology and cancer progression. Functions as an anti-adhesive molecule that maintains an open filtration pathway between neighboring foot processes in the podocyte by charge repulsion. Acts as a pro-adhesive molecule, enhancing the adherence of cells to immobilized ligands, increasing the rate of migration and cell-cell contacts in an integrin-dependent manner. Induces the formation of apical actin-dependent microvilli. Involved in the formation of a preapical plasma membrane subdomain to set up initial epithelial polarization and the apical lumen formation during renal tubulogenesis. Plays a role in cancer development and aggressiveness by inducing cell migration and invasion through its interaction with the actin-binding protein EZR. Affects EZR-dependent signaling events, leading to increased activities of the MAPK and PI3K pathways in cancer cells.|||Membrane|||Membrane raft|||filopodium|||lamellipodium|||microvillus|||ruffle http://togogenome.org/gene/13616:PTX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1C1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:KEG11_p12 ^@ http://purl.uniprot.org/uniprot/Q65CJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:KIF19 ^@ http://purl.uniprot.org/uniprot/F7CWX3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:MRPS33 ^@ http://purl.uniprot.org/uniprot/F6VE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/13616:SERPINB11 ^@ http://purl.uniprot.org/uniprot/F7D0K5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:LOC100618537 ^@ http://purl.uniprot.org/uniprot/F7E9F3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:UBE2T ^@ http://purl.uniprot.org/uniprot/F6SUA7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:ACTN3 ^@ http://purl.uniprot.org/uniprot/F7EL30 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/13616:ADAM10 ^@ http://purl.uniprot.org/uniprot/F6PTE7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:EPGN ^@ http://purl.uniprot.org/uniprot/A0A5F8H0I0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PSMB6 ^@ http://purl.uniprot.org/uniprot/F7FH35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TFE3 ^@ http://purl.uniprot.org/uniprot/F6R8X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/13616:LOC100011425 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:CCL21 ^@ http://purl.uniprot.org/uniprot/F7EBE9 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:SLC37A2 ^@ http://purl.uniprot.org/uniprot/F6Y317 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/13616:PARP6 ^@ http://purl.uniprot.org/uniprot/F6S5M1 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:SLC12A5 ^@ http://purl.uniprot.org/uniprot/F6WQ48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/13616:LOC100023020 ^@ http://purl.uniprot.org/uniprot/F7DSS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:POLR2E ^@ http://purl.uniprot.org/uniprot/A0A5F8HKJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, POLR2E/RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process.|||Nucleus http://togogenome.org/gene/13616:LOC100024383 ^@ http://purl.uniprot.org/uniprot/A0A5F8G959 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:CKS2 ^@ http://purl.uniprot.org/uniprot/F7DTK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/13616:VTA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Q5|||http://purl.uniprot.org/uniprot/A0A5F8HK02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:CBFB ^@ http://purl.uniprot.org/uniprot/F6ZRM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF-beta family.|||Nucleus http://togogenome.org/gene/13616:IL7R ^@ http://purl.uniprot.org/uniprot/F7FJP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/13616:CPLX3 ^@ http://purl.uniprot.org/uniprot/F6YXN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/13616:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH30|||http://purl.uniprot.org/uniprot/F6RG61 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:OBFC1 ^@ http://purl.uniprot.org/uniprot/F7A106 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STN1 family.|||Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/13616:ACOT13 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCZ3 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/13616:NR0B1 ^@ http://purl.uniprot.org/uniprot/F6UEV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:VN2R603 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTH5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AREG ^@ http://purl.uniprot.org/uniprot/F7A8Y1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PSMD12 ^@ http://purl.uniprot.org/uniprot/F7DST4 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/13616:STMN1 ^@ http://purl.uniprot.org/uniprot/F6V9E8 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/13616:COPE ^@ http://purl.uniprot.org/uniprot/F7EVS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated with ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/13616:LOC100015937 ^@ http://purl.uniprot.org/uniprot/F6Z372 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/13616:LOC100618314 ^@ http://purl.uniprot.org/uniprot/F7FZJ8 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/13616:CELF1 ^@ http://purl.uniprot.org/uniprot/F6VPK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SLC7A5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/13616:TARS2 ^@ http://purl.uniprot.org/uniprot/F6ZNQ0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:monDomV1R1250 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RPL27 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/13616:STAM2 ^@ http://purl.uniprot.org/uniprot/F7C3X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. Upon IL-2 and GM-CSL stimulation, it plays a role in signaling leading to DNA synthesis and MYC induction. May also play a role in T-cell development. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with HGS (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. http://togogenome.org/gene/13616:INSR ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ01|||http://purl.uniprot.org/uniprot/F7F370 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/13616:MMP8 ^@ http://purl.uniprot.org/uniprot/F6WLV8 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:GLIPR1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHY5 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/13616:LHX6 ^@ http://purl.uniprot.org/uniprot/F6TTC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:OST4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100018927 ^@ http://purl.uniprot.org/uniprot/F7CDT3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:USP5 ^@ http://purl.uniprot.org/uniprot/F7CWU5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:LOC100023355 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TCEB1 ^@ http://purl.uniprot.org/uniprot/K7E0T9 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/13616:LOC100617407 ^@ http://purl.uniprot.org/uniprot/F7AVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GMFG ^@ http://purl.uniprot.org/uniprot/F7FMW6 ^@ Similarity ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily. http://togogenome.org/gene/13616:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/F6V9A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100011470 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:CALB1 ^@ http://purl.uniprot.org/uniprot/F7BL42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calbindin family.|||Buffers cytosolic calcium. May stimulate a membrane Ca(2+)-ATPase and a 3',5'-cyclic nucleotide phosphodiesterase.|||Interacts with RANBP9. http://togogenome.org/gene/13616:RGS2 ^@ http://purl.uniprot.org/uniprot/F7FUH7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/13616:LOC100026485 ^@ http://purl.uniprot.org/uniprot/F7GF51 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ZNRF4 ^@ http://purl.uniprot.org/uniprot/F7D4D2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:AOC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIE6 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/13616:MAN2A1 ^@ http://purl.uniprot.org/uniprot/F7BEM8 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:GORASP2 ^@ http://purl.uniprot.org/uniprot/F7DHB7 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/13616:HOXB5 ^@ http://purl.uniprot.org/uniprot/F7E2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:SUPT20H ^@ http://purl.uniprot.org/uniprot/F6XMB7 ^@ Similarity ^@ Belongs to the SPT20 family. http://togogenome.org/gene/13616:NDUFAF3 ^@ http://purl.uniprot.org/uniprot/F6ZJF8 ^@ Function|||Subcellular Location Annotation ^@ Essential factor for the assembly of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Membrane|||Mitochondrion inner membrane|||Nucleus http://togogenome.org/gene/13616:ARSJ ^@ http://purl.uniprot.org/uniprot/F7DM73 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:MAEL ^@ http://purl.uniprot.org/uniprot/A0A5F8HJH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/13616:PDE8A ^@ http://purl.uniprot.org/uniprot/A0A5F8HGL4|||http://purl.uniprot.org/uniprot/F6WTB2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:HN1L ^@ http://purl.uniprot.org/uniprot/F7D6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:IFI30 ^@ http://purl.uniprot.org/uniprot/F6WUX5 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/13616:PLXNB1 ^@ http://purl.uniprot.org/uniprot/F6T7S8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100019669 ^@ http://purl.uniprot.org/uniprot/F7EVZ4 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/13616:LIX1 ^@ http://purl.uniprot.org/uniprot/F6SKK6 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/13616:MAPRE2 ^@ http://purl.uniprot.org/uniprot/F7GHT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||May be involved in microtubule polymerization, and spindle function by stabilizing microtubules and anchoring them at centrosomes. May play a role in cell migration.|||cytoskeleton http://togogenome.org/gene/13616:T2R29 ^@ http://purl.uniprot.org/uniprot/Q2AB90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:CNKSR3 ^@ http://purl.uniprot.org/uniprot/F7EKR3 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/13616:DPM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/13616:CPNE2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR65|||http://purl.uniprot.org/uniprot/A0A5F8HBU6 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/13616:UCK2 ^@ http://purl.uniprot.org/uniprot/F7FW97 ^@ Similarity|||Subunit ^@ Belongs to the uridine kinase family.|||Homotetramer. http://togogenome.org/gene/13616:TMEM63C ^@ http://purl.uniprot.org/uniprot/A0A5F8GYG1|||http://purl.uniprot.org/uniprot/A0A5F8HGW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/13616:SLC9A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3F8|||http://purl.uniprot.org/uniprot/F6WMC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/13616:LOC100024842 ^@ http://purl.uniprot.org/uniprot/F7B7L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/13616:CTSO ^@ http://purl.uniprot.org/uniprot/F6S7Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:ALDOA ^@ http://purl.uniprot.org/uniprot/F7E0Q7 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/13616:PRPF19 ^@ http://purl.uniprot.org/uniprot/F7FWM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/13616:CCNE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBJ0 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/13616:RIOK3 ^@ http://purl.uniprot.org/uniprot/F7G2S4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Involved in regulation of type I interferon (IFN)-dependent immune response which plays a critical role in the innate immune response against DNA and RNA viruses. http://togogenome.org/gene/13616:USP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHN6|||http://purl.uniprot.org/uniprot/F6ZBV9 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:MAU2 ^@ http://purl.uniprot.org/uniprot/F6RD67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC4/mau-2 family.|||nucleoplasm http://togogenome.org/gene/13616:RPL23A ^@ http://purl.uniprot.org/uniprot/F6RZ66 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/13616:LOC100012347 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:JPH1 ^@ http://purl.uniprot.org/uniprot/F6RFX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/13616:LOC100618909 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9X9 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/13616:ANXA10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAE0 ^@ Similarity ^@ Belongs to the annexin family. http://togogenome.org/gene/13616:CLTB ^@ http://purl.uniprot.org/uniprot/A0A5F8G6P9|||http://purl.uniprot.org/uniprot/F7DN20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/13616:MPP1 ^@ http://purl.uniprot.org/uniprot/F7DAK5 ^@ Function|||Subcellular Location Annotation ^@ Essential regulator of neutrophil polarity. Regulates neutrophil polarization by regulating AKT1 phosphorylation through a mechanism that is independent of PIK3CG activity.|||stereocilium http://togogenome.org/gene/13616:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GC45|||http://purl.uniprot.org/uniprot/A0A5F8GM99|||http://purl.uniprot.org/uniprot/F7CHC9 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/13616:RICTOR ^@ http://purl.uniprot.org/uniprot/A0A5F8HBY7|||http://purl.uniprot.org/uniprot/F7G7I0 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/13616:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKE4|||http://purl.uniprot.org/uniprot/F6Q0G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:F7 ^@ http://purl.uniprot.org/uniprot/F7D6Z7 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Heterodimer of a light chain and a heavy chain linked by a disulfide bond.|||Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:OTP ^@ http://purl.uniprot.org/uniprot/A0A5F8GIV9|||http://purl.uniprot.org/uniprot/F6X3W5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ARHGEF11 ^@ http://purl.uniprot.org/uniprot/F7E6J3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/13616:DAG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMJ7|||http://purl.uniprot.org/uniprot/F7DBT8 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||cytoskeleton|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/13616:ARL4C ^@ http://purl.uniprot.org/uniprot/F7ABF7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:LOC100618871 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRMT5 ^@ http://purl.uniprot.org/uniprot/F6PG51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/13616:SCP2 ^@ http://purl.uniprot.org/uniprot/F6XNE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Cytoplasm|||Interacts with PEX5; the interaction is essential for peroxisomal import.|||Mitochondrion|||Peroxisome http://togogenome.org/gene/13616:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWI7|||http://purl.uniprot.org/uniprot/F7GGI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/13616:LOC103098226 ^@ http://purl.uniprot.org/uniprot/K7E4I9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CFAP36 ^@ http://purl.uniprot.org/uniprot/F6WGE6 ^@ Similarity ^@ Belongs to the CFAP36 family. http://togogenome.org/gene/13616:CXCR4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell junction|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/13616:ESD ^@ http://purl.uniprot.org/uniprot/F6WZD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasmic vesicle|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/13616:MPPE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G431 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallophosphoesterase superfamily. MPPE1 family.|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with GPI-anchor proteins. Interacts with TMED10.|||Membrane|||Metallophosphoesterase required for transport of GPI-anchor proteins from the endoplasmic reticulum to the Golgi. Acts in lipid remodeling steps of GPI-anchor maturation by mediating the removal of a side-chain ethanolamine-phosphate (EtNP) from the second Man (Man2) of the GPI intermediate, an essential step for efficient transport of GPI-anchor proteins.|||cis-Golgi network membrane http://togogenome.org/gene/13616:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEC8|||http://purl.uniprot.org/uniprot/A0A5F8HHL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||May act as a zinc-influx transporter.|||Membrane http://togogenome.org/gene/13616:HNF4G ^@ http://purl.uniprot.org/uniprot/F6PGS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:WDR24 ^@ http://purl.uniprot.org/uniprot/F6YL80 ^@ Similarity ^@ Belongs to the WD repeat WDR24 family. http://togogenome.org/gene/13616:CELF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYZ7|||http://purl.uniprot.org/uniprot/F7CQQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DZIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0T6|||http://purl.uniprot.org/uniprot/F7DWD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||centriole|||cilium basal body http://togogenome.org/gene/13616:LOC100024102 ^@ http://purl.uniprot.org/uniprot/F6ZSS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HOXB9 ^@ http://purl.uniprot.org/uniprot/F7E2Q8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus|||Sequence-specific transcription factor which is part of a developmental regulatory system that provides cells with specific positional identities on the anterior-posterior axis. http://togogenome.org/gene/13616:ATP9B ^@ http://purl.uniprot.org/uniprot/A0A5F8GBY9|||http://purl.uniprot.org/uniprot/A0A5F8HEF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:POC5 ^@ http://purl.uniprot.org/uniprot/F6Q4B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/13616:LOC100023213 ^@ http://purl.uniprot.org/uniprot/F6V2K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100018507 ^@ http://purl.uniprot.org/uniprot/F6R6K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:CCNK ^@ http://purl.uniprot.org/uniprot/F7FQ20 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/13616:RARRES2 ^@ http://purl.uniprot.org/uniprot/F7C6M6 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:SMAD9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVH4|||http://purl.uniprot.org/uniprot/F6UAA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:HADHA ^@ http://purl.uniprot.org/uniprot/F7FE46 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/13616:AP5M1 ^@ http://purl.uniprot.org/uniprot/F7BJT0 ^@ Subcellular Location Annotation|||Subunit ^@ Late endosome membrane|||Lysosome membrane|||Membrane|||Probably part of the adaptor protein complex 5 (AP-5) a tetramer composed of AP5B1, AP5M1, AP5S1 and AP5Z1. http://togogenome.org/gene/13616:GATB ^@ http://purl.uniprot.org/uniprot/F6ZF69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/13616:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G462|||http://purl.uniprot.org/uniprot/A0A5F8GB11|||http://purl.uniprot.org/uniprot/A0A5F8GV53|||http://purl.uniprot.org/uniprot/A0A5F8H441|||http://purl.uniprot.org/uniprot/F6Y6D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:CCDC124 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CCDC124 family.|||Interacts with RASGEF1B.|||Required for proper progression of late cytokinetic stages. http://togogenome.org/gene/13616:GIMD1 ^@ http://purl.uniprot.org/uniprot/K7E119 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:NPVF ^@ http://purl.uniprot.org/uniprot/F6TB25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FARP (FMRFamide related peptide) family.|||Secreted http://togogenome.org/gene/13616:KIAA2013 ^@ http://purl.uniprot.org/uniprot/F7FJ41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100020400 ^@ http://purl.uniprot.org/uniprot/K7E0X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:TIMM8A ^@ http://purl.uniprot.org/uniprot/F6YEL5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/13616:C1S ^@ http://purl.uniprot.org/uniprot/F7CCG9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SPINK4 ^@ http://purl.uniprot.org/uniprot/F7D6E1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:KEG11_p06 ^@ http://purl.uniprot.org/uniprot/Q65CI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/13616:ME2 ^@ http://purl.uniprot.org/uniprot/F7BC34 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/13616:ICAM5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/13616:SEPT5 ^@ http://purl.uniprot.org/uniprot/F6STB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/13616:LOC100017632 ^@ http://purl.uniprot.org/uniprot/A0A5F8G589 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/13616:PRF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Secreted http://togogenome.org/gene/13616:ARG1 ^@ http://purl.uniprot.org/uniprot/F7B5B3 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/13616:PLIN2 ^@ http://purl.uniprot.org/uniprot/F7EPX6 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/13616:SMU1 ^@ http://purl.uniprot.org/uniprot/F7DWY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SMU1 family.|||Nucleus speckle http://togogenome.org/gene/13616:DONSON ^@ http://purl.uniprot.org/uniprot/F6VIV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DONSON family.|||Nucleus http://togogenome.org/gene/13616:SHOX ^@ http://purl.uniprot.org/uniprot/F6YBL9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:IL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-2 family.|||Cytokine produced by activated CD4-positive helper T-cells and to a lesser extend activated CD8-positive T-cells and natural killer (NK) cells that plays pivotal roles in the immune response and tolerance. Binds to a receptor complex composed of either the high-affinity trimeric IL-2R (IL2RA/CD25, IL2RB/CD122 and IL2RG/CD132) or the low-affinity dimeric IL-2R (IL2RB and IL2RG). Interaction with the receptor leads to oligomerization and conformation changes in the IL-2R subunits resulting in downstream signaling starting with phosphorylation of JAK1 and JAK3. In turn, JAK1 and JAK3 phosphorylate the receptor to form a docking site leading to the phosphorylation of several substrates including STAT5. This process leads to activation of several pathways including STAT, phosphoinositide-3-kinase/PI3K and mitogen-activated protein kinase/MAPK pathways. Functions as a T-cell growth factor and can increase NK-cell cytolytic activity as well. Promotes strong proliferation of activated B-cells and subsequently immunoglobulin production. Plays a pivotal role in regulating the adaptive immune system by controlling the survival and proliferation of regulatory T-cells, which are required for the maintenance of immune tolerance. Moreover, participates in the differentiation and homeostasis of effector T-cell subsets, including Th1, Th2, Th17 as well as memory CD8-positive T-cells.|||Secreted http://togogenome.org/gene/13616:CX3CR1 ^@ http://purl.uniprot.org/uniprot/F7CI96 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:YWHAB ^@ http://purl.uniprot.org/uniprot/A0A5F8GSA5 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:LOC100012665 ^@ http://purl.uniprot.org/uniprot/F6PGZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TMEM245 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGL3|||http://purl.uniprot.org/uniprot/F6PLR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/13616:LIF ^@ http://purl.uniprot.org/uniprot/F7EE29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIF/OSM family.|||LIF has the capacity to induce terminal differentiation in leukemic cells. Its activities include the induction of hematopoietic differentiation in normal and myeloid leukemia cells, the induction of neuronal cell differentiation, and the stimulation of acute-phase protein synthesis in hepatocytes.|||Secreted http://togogenome.org/gene/13616:VN2R583 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN55 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100024481 ^@ http://purl.uniprot.org/uniprot/F7F0L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FOXR1 ^@ http://purl.uniprot.org/uniprot/F7GA66 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PLN ^@ http://purl.uniprot.org/uniprot/F6V8P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/13616:ILVBL ^@ http://purl.uniprot.org/uniprot/F7ERP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPP enzyme family.|||Membrane http://togogenome.org/gene/13616:PLPPR4 ^@ http://purl.uniprot.org/uniprot/F7D869 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:MRPL16 ^@ http://purl.uniprot.org/uniprot/F7FXV3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/13616:TEKT3 ^@ http://purl.uniprot.org/uniprot/F7FNQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/13616:LOC100019177 ^@ http://purl.uniprot.org/uniprot/F7AJJ0 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/13616:LOC100021148 ^@ http://purl.uniprot.org/uniprot/F7AN22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PLRG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXT6|||http://purl.uniprot.org/uniprot/F7G7S0 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/13616:CCNDBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTB2|||http://purl.uniprot.org/uniprot/F6Z7U3 ^@ Similarity|||Subunit ^@ Belongs to the CCNDBP1 family.|||Interacts with CCND1 and GRAP2. May also interact with COPS5, RPLP0, SIRT6, SYF2 and TCF3. http://togogenome.org/gene/13616:VRK1 ^@ http://purl.uniprot.org/uniprot/F6QLF8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:AKR1E2 ^@ http://purl.uniprot.org/uniprot/F7DXB7 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/13616:LOC100022852 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103095354 ^@ http://purl.uniprot.org/uniprot/F7F0X2 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:TMEM43 ^@ http://purl.uniprot.org/uniprot/F7EXZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/13616:CHPT1 ^@ http://purl.uniprot.org/uniprot/F7GFA6 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/13616:LOC100031907 ^@ http://purl.uniprot.org/uniprot/F6XDY3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:POLR2G ^@ http://purl.uniprot.org/uniprot/K7E561 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits. RPB4 and RPB7 form a subcomplex that protrudes from the 10-subunit Pol II core complex.|||Nucleus http://togogenome.org/gene/13616:DUSP6 ^@ http://purl.uniprot.org/uniprot/F7ENU0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:MRGBP ^@ http://purl.uniprot.org/uniprot/F7FVJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Nucleus http://togogenome.org/gene/13616:GOT1 ^@ http://purl.uniprot.org/uniprot/F7GBD3 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/13616:ALG8 ^@ http://purl.uniprot.org/uniprot/F6WKY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:NOX4 ^@ http://purl.uniprot.org/uniprot/F6Z703 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100028951 ^@ http://purl.uniprot.org/uniprot/F6R9L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A5F8GWM4|||http://purl.uniprot.org/uniprot/F7ELV9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:ADCY2 ^@ http://purl.uniprot.org/uniprot/F6V001 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/13616:GATSL2 ^@ http://purl.uniprot.org/uniprot/F6PTR3 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/13616:SHCBP1L ^@ http://purl.uniprot.org/uniprot/F6QUP0 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/13616:NPY ^@ http://purl.uniprot.org/uniprot/F6VPU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/13616:RFX1 ^@ http://purl.uniprot.org/uniprot/F7ALG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NUS1 ^@ http://purl.uniprot.org/uniprot/F7CFL0 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/13616:STXBP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMQ2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/13616:UBE2F ^@ http://purl.uniprot.org/uniprot/F7CUS8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:ZPBP2 ^@ http://purl.uniprot.org/uniprot/F7GKP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/13616:CDK1 ^@ http://purl.uniprot.org/uniprot/F6V3X3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100012494 ^@ http://purl.uniprot.org/uniprot/F6T5H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 6A family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:UBE2N ^@ http://purl.uniprot.org/uniprot/F7FZL4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:IFT122 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW83|||http://purl.uniprot.org/uniprot/F7FGI2 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/13616:FOXP1 ^@ http://purl.uniprot.org/uniprot/F7E578 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MVB12B ^@ http://purl.uniprot.org/uniprot/A0A5F8GKE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MVB12 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/13616:LPAR2 ^@ http://purl.uniprot.org/uniprot/F6VRS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC7A4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CXCR5 ^@ http://purl.uniprot.org/uniprot/F7DTL3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:SLC17A5 ^@ http://purl.uniprot.org/uniprot/F7AG80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ATP5G1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/13616:GNG12 ^@ http://purl.uniprot.org/uniprot/F6SSS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:LOC100009948 ^@ http://purl.uniprot.org/uniprot/F7BR58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R632 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH37 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:NFE2L1 ^@ http://purl.uniprot.org/uniprot/F7DHJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. CNC subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:TNMD ^@ http://purl.uniprot.org/uniprot/F7BQF2 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/13616:S1PR4 ^@ http://purl.uniprot.org/uniprot/F7EC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:LOC100618325 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G970|||http://purl.uniprot.org/uniprot/F7BLA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:FUT10 ^@ http://purl.uniprot.org/uniprot/F7FP77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Predominantly fucosylates the innermost N-acetyl glucosamine (GlcNAc) residue in biantennary N-glycan acceptors. http://togogenome.org/gene/13616:TF ^@ http://purl.uniprot.org/uniprot/F7C9Z1 ^@ Similarity ^@ Belongs to the transferrin family. http://togogenome.org/gene/13616:LOC100028006 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SNRPG ^@ http://purl.uniprot.org/uniprot/F6RHM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays role in pre-mRNA splicing as core component of the SMN-Sm complex that mediates spliceosomal snRNP assembly and as component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/13616:SLC31A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/13616:TOP3B ^@ http://purl.uniprot.org/uniprot/F7FUS9 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/13616:TRHDE ^@ http://purl.uniprot.org/uniprot/A0A5F8G9Y3 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/13616:UBAC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SIAH2 ^@ http://purl.uniprot.org/uniprot/F7DVK7 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/13616:CUL1 ^@ http://purl.uniprot.org/uniprot/F6T584 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:LOC100028143 ^@ http://purl.uniprot.org/uniprot/F6TEL7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:TULP4 ^@ http://purl.uniprot.org/uniprot/F7FNH2 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/13616:SPRY2 ^@ http://purl.uniprot.org/uniprot/F7BBA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||ruffle membrane http://togogenome.org/gene/13616:ALAS1 ^@ http://purl.uniprot.org/uniprot/F7GEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:TMEM8A ^@ http://purl.uniprot.org/uniprot/F7E6Q5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:IL15 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/13616:UHRF2 ^@ http://purl.uniprot.org/uniprot/F6UK80 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LIMS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRJ2|||http://purl.uniprot.org/uniprot/A0A5F8H5W4|||http://purl.uniprot.org/uniprot/F7E2C4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Adapter protein in a cytoplasmic complex linking beta-integrins to the actin cytoskeleton, bridges the complex to cell surface receptor tyrosine kinases and growth factor receptors.|||Cell membrane|||Part of the heterotrimeric IPP complex composed of integrin-linked kinase (ILK), LIMS1 or LIMS2, and PARVA.|||focal adhesion http://togogenome.org/gene/13616:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2I7|||http://purl.uniprot.org/uniprot/F6XXZ8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:SLC39A2 ^@ http://purl.uniprot.org/uniprot/F6PG53 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TOMM22 ^@ http://purl.uniprot.org/uniprot/F6QTZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom22 family.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:SGTA ^@ http://purl.uniprot.org/uniprot/F7C205 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/13616:ATG13 ^@ http://purl.uniprot.org/uniprot/F7CFT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy factor required for autophagosome formation and mitophagy. Target of the TOR kinase signaling pathway that regulates autophagy through the control of the phosphorylation status of ATG13 and ULK1, and the regulation of the ATG13-ULK1-RB1CC1 complex. Through its regulation of ULK1 activity, plays a role in the regulation of the kinase activity of mTORC1 and cell proliferation.|||Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/13616:GNA11 ^@ http://purl.uniprot.org/uniprot/F7ECA6 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/13616:SAMM50 ^@ http://purl.uniprot.org/uniprot/F6ZTF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:MALSU1 ^@ http://purl.uniprot.org/uniprot/F6ZF75 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/13616:LOC100022719 ^@ http://purl.uniprot.org/uniprot/F7DG75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NDUFB8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100027633 ^@ http://purl.uniprot.org/uniprot/F6Z758 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/13616:ACAD8 ^@ http://purl.uniprot.org/uniprot/F7CGB6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:LOC100025055 ^@ http://purl.uniprot.org/uniprot/F7GIH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:WFIKKN1 ^@ http://purl.uniprot.org/uniprot/F7D2F1 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/13616:LOC100021467 ^@ http://purl.uniprot.org/uniprot/F7GHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:LOC100617634 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PARP1 ^@ http://purl.uniprot.org/uniprot/F7FES2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARTD/PARP family.|||Chromosome|||Interacts (when auto-poly-ADP-ribosylated) with AIFM1.|||Nucleus|||Poly-ADP-ribosyltransferase that mediates poly-ADP-ribosylation of proteins and plays a key role in DNA repair.|||This cleavage form irreversibly binds to DNA breaks and interferes with DNA repair, promoting DNA damage-induced apoptosis. http://togogenome.org/gene/13616:SNF8 ^@ http://purl.uniprot.org/uniprot/F6YG55 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/13616:USP13 ^@ http://purl.uniprot.org/uniprot/F7G3T7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:DBNDD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT25 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/13616:PKNOX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKA7|||http://purl.uniprot.org/uniprot/F6QYX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/13616:MOGAT3 ^@ http://purl.uniprot.org/uniprot/F7FKS4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SIDT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8S2|||http://purl.uniprot.org/uniprot/A0A5F8GAD1|||http://purl.uniprot.org/uniprot/F6UB87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SID1 family.|||Membrane http://togogenome.org/gene/13616:NUDT19 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUK1|||http://purl.uniprot.org/uniprot/A0A5F8HE42 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/13616:CACNB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4K2|||http://purl.uniprot.org/uniprot/F6VFL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Membrane|||sarcolemma http://togogenome.org/gene/13616:WDR45 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Preautophagosomal structure http://togogenome.org/gene/13616:LOC103099492 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDH8 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/13616:L3MBTL4 ^@ http://purl.uniprot.org/uniprot/F7GLP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TRMT6 ^@ http://purl.uniprot.org/uniprot/F7AA51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/13616:VN2R555 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN76 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC107649499 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/13616:TYRP1 ^@ http://purl.uniprot.org/uniprot/F7FUN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/13616:PREP ^@ http://purl.uniprot.org/uniprot/F6ZWJ1 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/13616:ALOX5 ^@ http://purl.uniprot.org/uniprot/F7FJV9 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PIH1D3 ^@ http://purl.uniprot.org/uniprot/F7DF68 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/13616:VPS53 ^@ http://purl.uniprot.org/uniprot/F6WN34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/13616:CENPT ^@ http://purl.uniprot.org/uniprot/A0A5F8GK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-T/CNN1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/13616:CECR1 ^@ http://purl.uniprot.org/uniprot/F7CUH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/13616:DCAF13 ^@ http://purl.uniprot.org/uniprot/F7FHD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/13616:LOC100017853 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD68 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:YY1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN11|||http://purl.uniprot.org/uniprot/F7BM88 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/13616:DENR ^@ http://purl.uniprot.org/uniprot/A0A5F8GGX6 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/13616:TBCCD1 ^@ http://purl.uniprot.org/uniprot/F6ZJD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCC family.|||centrosome|||spindle pole http://togogenome.org/gene/13616:LOC100019634 ^@ http://purl.uniprot.org/uniprot/F6YRD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RAB29 ^@ http://purl.uniprot.org/uniprot/F6SPF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/13616:CKMT1A ^@ http://purl.uniprot.org/uniprot/F7DJD6 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/13616:NKX2-2 ^@ http://purl.uniprot.org/uniprot/F7B516 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H593 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||Monomer.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/13616:PITX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H975 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/13616:HSPB2 ^@ http://purl.uniprot.org/uniprot/F7ATU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/13616:LRRC8D ^@ http://purl.uniprot.org/uniprot/A0A5F8HD08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PARP16 ^@ http://purl.uniprot.org/uniprot/A0A5F8H951 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:LOC100017394 ^@ http://purl.uniprot.org/uniprot/F6Z9R8 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/13616:GLO1 ^@ http://purl.uniprot.org/uniprot/F7ECV7 ^@ Function|||Similarity ^@ Belongs to the glyoxalase I family.|||Catalyzes the conversion of hemimercaptal, formed from methylglyoxal and glutathione, to S-lactoylglutathione. http://togogenome.org/gene/13616:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A5F8GTK4|||http://purl.uniprot.org/uniprot/A0A5F8H6Y5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:DHPS ^@ http://purl.uniprot.org/uniprot/F6PGR5 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/13616:PIANP ^@ http://purl.uniprot.org/uniprot/F7FFB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FER ^@ http://purl.uniprot.org/uniprot/A0A5F8G8M2|||http://purl.uniprot.org/uniprot/F7FIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/13616:LOC100010821 ^@ http://purl.uniprot.org/uniprot/F6R929 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/13616:GSDMD ^@ http://purl.uniprot.org/uniprot/F6WZ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CES2.1 ^@ http://purl.uniprot.org/uniprot/B2BSF5|||http://purl.uniprot.org/uniprot/F7C870 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/13616:CHAF1B ^@ http://purl.uniprot.org/uniprot/F6RJB6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SMDT1 ^@ http://purl.uniprot.org/uniprot/F6UFP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A5F8GKW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/13616:LOC100025235 ^@ http://purl.uniprot.org/uniprot/F7GFJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/13616:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFF9|||http://purl.uniprot.org/uniprot/F7FRY0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/13616:TMEM186 ^@ http://purl.uniprot.org/uniprot/F6QE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM186 family.|||Membrane http://togogenome.org/gene/13616:LOC100022881 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MTERF2 ^@ http://purl.uniprot.org/uniprot/F7BBD3 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/13616:CNOT1 ^@ http://purl.uniprot.org/uniprot/F6TR11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/13616:RASSF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5U5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:LOC100017544 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7L7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:CNOT9 ^@ http://purl.uniprot.org/uniprot/F6T3G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT9 family.|||P-body http://togogenome.org/gene/13616:AES ^@ http://purl.uniprot.org/uniprot/F7ECH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/13616:ADCK5 ^@ http://purl.uniprot.org/uniprot/F7G7M7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/13616:LOC100024470 ^@ http://purl.uniprot.org/uniprot/F7FFX8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/13616:GDF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6L7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:MLH3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIQ8|||http://purl.uniprot.org/uniprot/F6ZUC5 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/13616:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A5F8GHS6|||http://purl.uniprot.org/uniprot/A0A5F8GN33|||http://purl.uniprot.org/uniprot/A0A5F8GTD7|||http://purl.uniprot.org/uniprot/F6YH59 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/13616:PARPBP ^@ http://purl.uniprot.org/uniprot/A0A5F8G9K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PARI family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:NXPH3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/13616:ATG12 ^@ http://purl.uniprot.org/uniprot/F6UDZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Ubiquitin-like protein involved in autophagic vesicle formation. http://togogenome.org/gene/13616:JPH2 ^@ http://purl.uniprot.org/uniprot/F7FLU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/13616:HGD ^@ http://purl.uniprot.org/uniprot/F6PGC2 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/13616:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEP6|||http://purl.uniprot.org/uniprot/A0A5F8GT03 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/13616:EEF1D ^@ http://purl.uniprot.org/uniprot/K7E448 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/13616:LOC100017283 ^@ http://purl.uniprot.org/uniprot/F6TJJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:LOC100032364 ^@ http://purl.uniprot.org/uniprot/F6XPY0 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/13616:MLF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/13616:SEC61A1 ^@ http://purl.uniprot.org/uniprot/F7D5U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:WHAMM ^@ http://purl.uniprot.org/uniprot/F7AXA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NUP188 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD79|||http://purl.uniprot.org/uniprot/F7GEX1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/13616:USP9X ^@ http://purl.uniprot.org/uniprot/F6UID4 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/13616:BABAM1 ^@ http://purl.uniprot.org/uniprot/F7FHA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:C6H16orf13 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9S4 ^@ Similarity ^@ Belongs to the UPF0585 family. http://togogenome.org/gene/13616:MRPL28 ^@ http://purl.uniprot.org/uniprot/F7E6R6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/13616:PPP2R3C ^@ http://purl.uniprot.org/uniprot/F7GKQ5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:HOXA5 ^@ http://purl.uniprot.org/uniprot/F6UA74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:EFHC2 ^@ http://purl.uniprot.org/uniprot/F6UIX5 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/13616:MOCS2 ^@ http://purl.uniprot.org/uniprot/F6RWP4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the small subunit (MOCS2A) from an overlapping reading frame.|||cytosol http://togogenome.org/gene/13616:PRDX6 ^@ http://purl.uniprot.org/uniprot/F7CMG3 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/13616:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A5F8HKZ2|||http://purl.uniprot.org/uniprot/F6QN59 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/13616:ALPL ^@ http://purl.uniprot.org/uniprot/F7EGD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EIF2S2 ^@ http://purl.uniprot.org/uniprot/F7EJH2 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/13616:OTC ^@ http://purl.uniprot.org/uniprot/F6UHY3 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/13616:LIN28B ^@ http://purl.uniprot.org/uniprot/A0A5F8GUV7|||http://purl.uniprot.org/uniprot/A0A5F8GZQ7|||http://purl.uniprot.org/uniprot/A0A5F8HHJ1|||http://purl.uniprot.org/uniprot/F6ZWF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/13616:PGLS ^@ http://purl.uniprot.org/uniprot/F6SVN1 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/13616:MMP14 ^@ http://purl.uniprot.org/uniprot/F7E6W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Cytoplasm|||Melanosome http://togogenome.org/gene/13616:RBBP5 ^@ http://purl.uniprot.org/uniprot/F6RMK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SPC25 ^@ http://purl.uniprot.org/uniprot/F7BJE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/13616:OTX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/13616:PKM ^@ http://purl.uniprot.org/uniprot/A0A5F8GJZ6|||http://purl.uniprot.org/uniprot/F6WGC5 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/13616:LOC100025761 ^@ http://purl.uniprot.org/uniprot/F6VK86 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/13616:PARP11 ^@ http://purl.uniprot.org/uniprot/F6PTG4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:SRMS ^@ http://purl.uniprot.org/uniprot/F6XJB6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:APOE ^@ http://purl.uniprot.org/uniprot/A0A5F8HC70 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/13616:ATP6V0E2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H893 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:NOL6 ^@ http://purl.uniprot.org/uniprot/F6ZJX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/13616:TAF6L ^@ http://purl.uniprot.org/uniprot/F7D588 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/13616:GRIN3A ^@ http://purl.uniprot.org/uniprot/F7AUG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/13616:LOC100018407 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA63 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NELFCD ^@ http://purl.uniprot.org/uniprot/F6ZD99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/13616:LOC100017089 ^@ http://purl.uniprot.org/uniprot/F6XDL1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/13616:PREPL ^@ http://purl.uniprot.org/uniprot/A0A5F8HHU7 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/13616:BBOX1 ^@ http://purl.uniprot.org/uniprot/F7BLG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-BBH/TMLD family.|||Catalyzes the formation of L-carnitine from gamma-butyrobetaine.|||Cytoplasm http://togogenome.org/gene/13616:HS3ST2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GST9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:NAP1L4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBE0|||http://purl.uniprot.org/uniprot/A0A5F8HAQ3|||http://purl.uniprot.org/uniprot/F6XTV9 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/13616:ANAPC16 ^@ http://purl.uniprot.org/uniprot/F6S1D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC16 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||Cytoplasm|||Nucleus|||kinetochore http://togogenome.org/gene/13616:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5N6|||http://purl.uniprot.org/uniprot/A0A5F8GT71|||http://purl.uniprot.org/uniprot/A0A5F8H6Z8|||http://purl.uniprot.org/uniprot/F7EC31 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:APPL2 ^@ http://purl.uniprot.org/uniprot/F6RII3 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/13616:CCDC67 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA50|||http://purl.uniprot.org/uniprot/A0A5F8GVV7|||http://purl.uniprot.org/uniprot/F6ZGK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP63 family.|||Cytoplasm http://togogenome.org/gene/13616:NIPA2 ^@ http://purl.uniprot.org/uniprot/F6X4W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/13616:TYW1 ^@ http://purl.uniprot.org/uniprot/F6TJ39 ^@ Function|||Similarity ^@ Belongs to the TYW1 family.|||Probable component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine, an intermediate in wybutosine biosynthesis. http://togogenome.org/gene/13616:LYVE1 ^@ http://purl.uniprot.org/uniprot/F7AL98 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CRTC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMY9|||http://purl.uniprot.org/uniprot/A0A5F8HFZ2|||http://purl.uniprot.org/uniprot/F7C6I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TORC family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:ARGLU1 ^@ http://purl.uniprot.org/uniprot/F7FHF8 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/13616:TMEM135 ^@ http://purl.uniprot.org/uniprot/F6VVY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/13616:PKD1 ^@ http://purl.uniprot.org/uniprot/F6YV18 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100010706 ^@ http://purl.uniprot.org/uniprot/F6YIL8 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/13616:SDHA ^@ http://purl.uniprot.org/uniprot/F6TAP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/13616:MAP3K10 ^@ http://purl.uniprot.org/uniprot/F7CPB8 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/13616:CHD8 ^@ http://purl.uniprot.org/uniprot/F7FS88 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. CHD8 subfamily.|||DNA helicase that acts as a chromatin remodeling factor and regulates transcription. Acts as a transcription repressor by remodeling chromatin structure and recruiting histone H1 to target genes. Suppresses p53/TP53-mediated apoptosis by recruiting histone H1 and preventing p53/TP53 transactivation activity. Acts as a negative regulator of Wnt signaling pathway by regulating beta-catenin (CTNNB1) activity. Negatively regulates CTNNB1-targeted gene expression by being recruited specifically to the promoter regions of several CTNNB1 responsive genes. Involved in both enhancer blocking and epigenetic remodeling at chromatin boundary via its interaction with CTCF. Acts as a suppressor of STAT3 activity by suppressing the LIF-induced STAT3 transcriptional activity. Also acts as a transcription activator via its interaction with ZNF143 by participating in efficient U6 RNA polymerase III transcription.|||Interacts with p53/TP53, histone H1, CTNNB1, CTCF and PIAS3. Component of some MLL1/MLL complex, at least composed of the core components KMT2A/MLL1, ASH2L, HCFC1/HCF1, WDR5 and RBBP5, as well as the facultative components BAP18, CHD8, E2F6, HSP70, INO80C, KANSL1, LAS1L, MAX, MCRS1, MGA, KAT8/MOF, PELP1, PHF20, PRP31, RING2, RUVB1/TIP49A, RUVB2/TIP49B, SENP3, TAF1, TAF4, TAF6, TAF7, TAF9 and TEX10. Interacts with CHD7. Interacts with FAM124B.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Sumoylated. http://togogenome.org/gene/13616:BCDIN3D ^@ http://purl.uniprot.org/uniprot/A0A5F8HB75 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/13616:ACP5 ^@ http://purl.uniprot.org/uniprot/F7DGU8 ^@ Cofactor ^@ Binds 2 iron ions per subunit. http://togogenome.org/gene/13616:PAM ^@ http://purl.uniprot.org/uniprot/A0A5F8G7W8|||http://purl.uniprot.org/uniprot/A0A5F8H1V1|||http://purl.uniprot.org/uniprot/F6SHA5 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the peptidyl-alpha-hydroxyglycine alpha-amidating lyase family.|||In the N-terminal section; belongs to the copper type II ascorbate-dependent monooxygenase family.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/13616:TWF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/13616:GALK1 ^@ http://purl.uniprot.org/uniprot/F7BKK7 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/13616:HSPB3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/13616:ABRACL ^@ http://purl.uniprot.org/uniprot/F6SM16 ^@ Similarity ^@ Belongs to the costars family. http://togogenome.org/gene/13616:LHFPL5 ^@ http://purl.uniprot.org/uniprot/F6X7Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPL11 ^@ http://purl.uniprot.org/uniprot/F7DD44 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/13616:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/13616:ATP5L ^@ http://purl.uniprot.org/uniprot/A0A5F8GEH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/13616:TATDN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEE7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/13616:TAF6 ^@ http://purl.uniprot.org/uniprot/F6TDR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/13616:HYAL2 ^@ http://purl.uniprot.org/uniprot/F7FU16 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/13616:MANBA ^@ http://purl.uniprot.org/uniprot/A0A5F8G3D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/13616:VWC2L ^@ http://purl.uniprot.org/uniprot/F7FEN3 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/13616:LOC100028244 ^@ http://purl.uniprot.org/uniprot/F6WRA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/13616:UBIAD1 ^@ http://purl.uniprot.org/uniprot/F7E5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/13616:TMSB4X ^@ http://purl.uniprot.org/uniprot/F7ENP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/13616:BTAF1 ^@ http://purl.uniprot.org/uniprot/F7DH73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAM110B ^@ http://purl.uniprot.org/uniprot/F7B486 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/13616:CCNE2 ^@ http://purl.uniprot.org/uniprot/F6UFV2 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/13616:GDF3 ^@ http://purl.uniprot.org/uniprot/F7AL60 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:TMEM199 ^@ http://purl.uniprot.org/uniprot/F6QU23 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CREB5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a homodimer or as a heterodimer with JUN or ATF2/CREBP1.|||Binds to the cAMP response element and activates transcription.|||Nucleus http://togogenome.org/gene/13616:CASP14 ^@ http://purl.uniprot.org/uniprot/A5HAU7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:C1H10orf53 ^@ http://purl.uniprot.org/uniprot/F6TCD6 ^@ Similarity ^@ Belongs to the UPF0728 family. http://togogenome.org/gene/13616:THRSP ^@ http://purl.uniprot.org/uniprot/F7GGM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:FAM105A ^@ http://purl.uniprot.org/uniprot/F6PMI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100012489 ^@ http://purl.uniprot.org/uniprot/F7A9N5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/13616:LOC100619366 ^@ http://purl.uniprot.org/uniprot/F6YPS6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:KCNA6 ^@ http://purl.uniprot.org/uniprot/F7AL46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:BAG6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5L2|||http://purl.uniprot.org/uniprot/A0A5F8HL30|||http://purl.uniprot.org/uniprot/F6VB03 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Released extracellularly via exosomes, it is a ligand of the natural killer/NK cells receptor NCR3 and stimulates NK cells cytotoxicity. It may thereby trigger NK cells cytotoxicity against neighboring tumor cells and immature myeloid dendritic cells (DC).|||extracellular exosome http://togogenome.org/gene/13616:HDAC2 ^@ http://purl.uniprot.org/uniprot/F6YIM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/13616:SOST ^@ http://purl.uniprot.org/uniprot/A0A5F8GCV4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the sclerostin family.|||Interacts with LRP4 (via the extracellular domain); the interaction facilitates the inhibition of Wnt signaling. Interacts with LRP5 (via the first two YWTD-EGF repeat domains); the interaction inhibits Wnt-mediated signaling. Interacts with LRP6.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Negative regulator of bone growth that acts through inhibition of Wnt signaling and bone formation. http://togogenome.org/gene/13616:KBTBD8 ^@ http://purl.uniprot.org/uniprot/F7EYU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KBTBD8 family.|||Golgi apparatus|||spindle http://togogenome.org/gene/13616:FMOD ^@ http://purl.uniprot.org/uniprot/F7DPP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Affects the rate of fibrils formation. May have a primary role in collagen fibrillogenesis.|||Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to type I and type II collagen.|||extracellular matrix http://togogenome.org/gene/13616:CSTB ^@ http://purl.uniprot.org/uniprot/F6W0H8 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/13616:ING4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H269 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/13616:UPK1B ^@ http://purl.uniprot.org/uniprot/F7B797 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tetraspanin (TM4SF) family.|||Heterodimer with uroplakin-3A (UPK3A) or uroplakin-3B (UPK3B).|||Membrane http://togogenome.org/gene/13616:LOC103098338 ^@ http://purl.uniprot.org/uniprot/F7E383 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/13616:IP6K3 ^@ http://purl.uniprot.org/uniprot/F6QKC1 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/13616:ZPBP ^@ http://purl.uniprot.org/uniprot/F6YX37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/13616:SNX20 ^@ http://purl.uniprot.org/uniprot/F7FBP4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:DSC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN48 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/13616:GNG4 ^@ http://purl.uniprot.org/uniprot/K7E376 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:LOC100024593 ^@ http://purl.uniprot.org/uniprot/F6PYX9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:CHMP6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJB8 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:GNPAT ^@ http://purl.uniprot.org/uniprot/A0A5F8GDK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/13616:FGFR4 ^@ http://purl.uniprot.org/uniprot/F7C211 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DDIT4 ^@ http://purl.uniprot.org/uniprot/F6S0G1 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/13616:DNAJB14 ^@ http://purl.uniprot.org/uniprot/F7DKI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:EDA ^@ http://purl.uniprot.org/uniprot/F6UN90 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/13616:MVP ^@ http://purl.uniprot.org/uniprot/A0A5F8GFC1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Required for normal vault structure. Vaults are multi-subunit structures that may act as scaffolds for proteins involved in signal transduction. Vaults may also play a role in nucleo-cytoplasmic transport. Down-regulates IFNG-mediated STAT1 signaling and subsequent activation of JAK. Down-regulates SRC activity and signaling through MAP kinases. http://togogenome.org/gene/13616:EPHA7 ^@ http://purl.uniprot.org/uniprot/F7CWR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PRDM5 ^@ http://purl.uniprot.org/uniprot/F7GB24 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100032596 ^@ http://purl.uniprot.org/uniprot/F7G5S9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:XPA ^@ http://purl.uniprot.org/uniprot/F6TZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPA family.|||Nucleus http://togogenome.org/gene/13616:LMX1B ^@ http://purl.uniprot.org/uniprot/F6TAA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CALHM2 ^@ http://purl.uniprot.org/uniprot/F7F446 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:AVPR1A ^@ http://purl.uniprot.org/uniprot/F6UMG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/13616:GCG ^@ http://purl.uniprot.org/uniprot/F7F3N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/13616:ANXA6 ^@ http://purl.uniprot.org/uniprot/F6TXS8|||http://purl.uniprot.org/uniprot/F6YX46 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/13616:SQSTM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH66|||http://purl.uniprot.org/uniprot/F6ZJ90 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/13616:LOC103095221 ^@ http://purl.uniprot.org/uniprot/F7FXP6 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:CD164 ^@ http://purl.uniprot.org/uniprot/F7BUT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/13616:IPO5 ^@ http://purl.uniprot.org/uniprot/F7FFK8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:HRH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2U8|||http://purl.uniprot.org/uniprot/F6YL33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100032991 ^@ http://purl.uniprot.org/uniprot/F7CND5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TRDMT1 ^@ http://purl.uniprot.org/uniprot/F6WAN0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/13616:NECAP2 ^@ http://purl.uniprot.org/uniprot/F6PIG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/13616:YES1 ^@ http://purl.uniprot.org/uniprot/F7G374 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:RET ^@ http://purl.uniprot.org/uniprot/F7G7S6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family.|||Cell membrane|||Receptor tyrosine-protein kinase involved in numerous cellular mechanisms including cell proliferation, neuronal navigation, cell migration, and cell differentiation upon binding with glial cell derived neurotrophic factor family ligands. http://togogenome.org/gene/13616:TRMU ^@ http://purl.uniprot.org/uniprot/F7DWM5 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/13616:UBLCP1 ^@ http://purl.uniprot.org/uniprot/F6YKB6 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/13616:DNMBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GVN5|||http://purl.uniprot.org/uniprot/F6XNN0 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack|||Synapse|||cytoskeleton http://togogenome.org/gene/13616:NKX3-1 ^@ http://purl.uniprot.org/uniprot/F7G683 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TRIP12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/13616:VN2R553 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLZ1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:UBE2G1 ^@ http://purl.uniprot.org/uniprot/F7G2B2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:LHX9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW30|||http://purl.uniprot.org/uniprot/F6T103 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UPP1 ^@ http://purl.uniprot.org/uniprot/F7C5E7 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/13616:FERMT2 ^@ http://purl.uniprot.org/uniprot/F7BNK8 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/13616:MTMR6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXW6|||http://purl.uniprot.org/uniprot/F7CX78 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/13616:CTSB ^@ http://purl.uniprot.org/uniprot/F7ALZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:ALAD ^@ http://purl.uniprot.org/uniprot/F6SVR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer; active form. Homohexamer; low activity form. http://togogenome.org/gene/13616:LOC100031971 ^@ http://purl.uniprot.org/uniprot/F7G922 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC100031975 ^@ http://purl.uniprot.org/uniprot/F6TYS0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC100024398 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GAR1 ^@ http://purl.uniprot.org/uniprot/F7E2W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/13616:ABCG1 ^@ http://purl.uniprot.org/uniprot/F6QZE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100022185 ^@ http://purl.uniprot.org/uniprot/F7BVK1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ADRA1B ^@ http://purl.uniprot.org/uniprot/F7CKY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/13616:TUBD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4K3|||http://purl.uniprot.org/uniprot/F6V570 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/13616:SH3YL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8M0|||http://purl.uniprot.org/uniprot/F6XJ09 ^@ Similarity|||Subunit ^@ Belongs to the SH3YL1 family.|||Interacts with SH3D19. http://togogenome.org/gene/13616:GTF2B ^@ http://purl.uniprot.org/uniprot/F6PMC9 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/13616:SCN3A ^@ http://purl.uniprot.org/uniprot/A0A5F8HFU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/13616:SFPQ ^@ http://purl.uniprot.org/uniprot/A0A5F8G4R8|||http://purl.uniprot.org/uniprot/A0A5F8GPT0 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/13616:EN1 ^@ http://purl.uniprot.org/uniprot/F7FKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/13616:GOSR2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7B8|||http://purl.uniprot.org/uniprot/F7E5G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR2 family.|||Involved in transport of proteins from the cis/medial-Golgi to the trans-Golgi network.|||Membrane http://togogenome.org/gene/13616:KAT7 ^@ http://purl.uniprot.org/uniprot/F7DHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/13616:CD14 ^@ http://purl.uniprot.org/uniprot/F6SDH5 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/13616:PQLC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDI0|||http://purl.uniprot.org/uniprot/F7B9T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SPDYA ^@ http://purl.uniprot.org/uniprot/A0A5F8H7N2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/13616:GPR4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TSTA3 ^@ http://purl.uniprot.org/uniprot/F6ZAF0 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/13616:NRXN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGY5|||http://purl.uniprot.org/uniprot/F7BZM4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LIPC ^@ http://purl.uniprot.org/uniprot/A0A5F8G1W6|||http://purl.uniprot.org/uniprot/F6PXQ2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:RPL13 ^@ http://purl.uniprot.org/uniprot/F7ACE7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/13616:LOC100010438 ^@ http://purl.uniprot.org/uniprot/F6TF19 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/13616:PAQR8 ^@ http://purl.uniprot.org/uniprot/F6Z2L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:KPNA6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFC7|||http://purl.uniprot.org/uniprot/F7E1F4 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:CASP18 ^@ http://purl.uniprot.org/uniprot/A9YDV7|||http://purl.uniprot.org/uniprot/K7E316 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:LOC100020741 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RPL9 ^@ http://purl.uniprot.org/uniprot/F7AQ39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/13616:DDC ^@ http://purl.uniprot.org/uniprot/A0A5F8H514 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:CAPN10 ^@ http://purl.uniprot.org/uniprot/F7CY16 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/13616:TMEM206 ^@ http://purl.uniprot.org/uniprot/F6Q562 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SPSB4 ^@ http://purl.uniprot.org/uniprot/F7B312 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/13616:JRKL ^@ http://purl.uniprot.org/uniprot/F7GFT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tigger transposable element derived protein family.|||Nucleus http://togogenome.org/gene/13616:LOC100010714 ^@ http://purl.uniprot.org/uniprot/F7B277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:S100Z ^@ http://purl.uniprot.org/uniprot/F6WNQ1 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/13616:LOC103096977 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAN6 ^@ Similarity ^@ Belongs to the BLOC1S2 family. http://togogenome.org/gene/13616:MGST1 ^@ http://purl.uniprot.org/uniprot/F7FGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/13616:REV3L ^@ http://purl.uniprot.org/uniprot/A0A5F8GU36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/13616:EIF3B ^@ http://purl.uniprot.org/uniprot/F6SZX9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Also interacts with UPF2. Interacts with METTL3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Cytoplasm|||Phosphorylated. Phosphorylation is enhanced upon serum stimulation.|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||The RRM domain mediates interaction with EIF3J. http://togogenome.org/gene/13616:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/F7FT59 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/13616:UGDH ^@ http://purl.uniprot.org/uniprot/F7AQE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/13616:LOC100029165 ^@ http://purl.uniprot.org/uniprot/F7FZW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:IDH3A ^@ http://purl.uniprot.org/uniprot/F6TJ83 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Heterooligomer of subunits alpha (IDH3A), beta (IDH3B), and gamma (IDH3G) in the apparent ratio of 2:1:1. The heterodimer containing one IDH3A and one IDH3B subunit and the heterodimer containing one IDH3A and one IDH3G subunit assemble into a heterotetramer (which contains two subunits of IDH3A, one of IDH3B and one of IDH3G) and further into the heterooctamer.|||Mitochondrion http://togogenome.org/gene/13616:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A5F8G8L8|||http://purl.uniprot.org/uniprot/A0A5F8GAZ5|||http://purl.uniprot.org/uniprot/A0A5F8H915 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1237 ^@ http://purl.uniprot.org/uniprot/F7GES2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RRP1B ^@ http://purl.uniprot.org/uniprot/F6W0J2 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/13616:LOC100618822 ^@ http://purl.uniprot.org/uniprot/A0A5F8G951 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:BTG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GS31 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/13616:AATF ^@ http://purl.uniprot.org/uniprot/F7EGI5 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/13616:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/E4ZFH4|||http://purl.uniprot.org/uniprot/F6YWA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:GTF3C5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAM57B ^@ http://purl.uniprot.org/uniprot/F7DGI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CDKN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE70|||http://purl.uniprot.org/uniprot/F6UZN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||May play a role in cell cycle regulation. Dual specificity phosphatase active toward substrates containing either phosphotyrosine or phosphoserine residues.|||perinuclear region http://togogenome.org/gene/13616:MCM2 ^@ http://purl.uniprot.org/uniprot/F6ZG72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:SEMA4A ^@ http://purl.uniprot.org/uniprot/A0A5F8G4H1|||http://purl.uniprot.org/uniprot/F6VN06 ^@ Similarity ^@ Belongs to the semaphorin family. http://togogenome.org/gene/13616:CSAD ^@ http://purl.uniprot.org/uniprot/F7G221 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:YBEY ^@ http://purl.uniprot.org/uniprot/F7GEX4 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/13616:SLC16A13 ^@ http://purl.uniprot.org/uniprot/F6ZJR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NAT10 ^@ http://purl.uniprot.org/uniprot/F6VCE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with THUMPD1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein THUMPD1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/13616:TUBB1 ^@ http://purl.uniprot.org/uniprot/F6ZCX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:LOC100015374 ^@ http://purl.uniprot.org/uniprot/F7CLT7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:C7H3orf58 ^@ http://purl.uniprot.org/uniprot/F6TJE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/13616:ATP6AP1 ^@ http://purl.uniprot.org/uniprot/F7CAZ5 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/13616:SERPINB5 ^@ http://purl.uniprot.org/uniprot/F7DMP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family. Ov-serpin subfamily.|||extracellular space http://togogenome.org/gene/13616:VN2R590 ^@ http://purl.uniprot.org/uniprot/H9H846 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:FXR2 ^@ http://purl.uniprot.org/uniprot/F6XS15 ^@ Similarity ^@ Belongs to the FMR1 family. http://togogenome.org/gene/13616:PRPH2 ^@ http://purl.uniprot.org/uniprot/F7BLI0 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/13616:PSD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLW2 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/13616:LOC100016275 ^@ http://purl.uniprot.org/uniprot/F6RQ81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:CNIH4 ^@ http://purl.uniprot.org/uniprot/F7DP14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/13616:FZD8 ^@ http://purl.uniprot.org/uniprot/F7CDC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/13616:NAALAD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWN8|||http://purl.uniprot.org/uniprot/F7EFS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:POLD3 ^@ http://purl.uniprot.org/uniprot/F6X936 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMCC1 ^@ http://purl.uniprot.org/uniprot/F6QA24 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/13616:LIN9 ^@ http://purl.uniprot.org/uniprot/F6ZUZ8 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/13616:PSMD6 ^@ http://purl.uniprot.org/uniprot/F6PLG4 ^@ Similarity ^@ Belongs to the proteasome subunit S10 family. http://togogenome.org/gene/13616:PIK3CA ^@ http://purl.uniprot.org/uniprot/F7G3I5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/13616:SPATS2L ^@ http://purl.uniprot.org/uniprot/F6PMD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATS2 family.|||Cytoplasm http://togogenome.org/gene/13616:NPHS2 ^@ http://purl.uniprot.org/uniprot/F7BSK5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/13616:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A5F8H9I6 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/13616:LOC103099919 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQL3 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/13616:ZNF277 ^@ http://purl.uniprot.org/uniprot/F6ZR18 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/13616:PKD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBJ0|||http://purl.uniprot.org/uniprot/F7ANU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/13616:MARVELD1 ^@ http://purl.uniprot.org/uniprot/F7CNW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NELL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGW1|||http://purl.uniprot.org/uniprot/F7EDR3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NEDD8 ^@ http://purl.uniprot.org/uniprot/F6T1M0 ^@ Similarity ^@ Belongs to the ubiquitin family. http://togogenome.org/gene/13616:LOC100030497 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HS3ST6 ^@ http://purl.uniprot.org/uniprot/F6YUM6 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:KCNA7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GDNF ^@ http://purl.uniprot.org/uniprot/F7FWY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/13616:monDomV1R1212 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HDHD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTJ0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/13616:MCU ^@ http://purl.uniprot.org/uniprot/A0A5F8GW32 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Forms a well-packed pentamer with an overall cylindrical shape. The inner core of the pentamer is formed with the second transmembrane region and the second coiled-coil region: while the transmembrane regions pack into a five-helix bundle having a largely polar pore across the membrane, the coiled-coil outside the membrane forms a pentamer with a hydrophobic core. The inner core is wrapped by the first transmembrane region through contacts between the first and the second transmembrane regions. The second transmembrane is followed by the inner juxtamembrane region (IJMH) that orients at a wide angle relative to the second transmembrane. The two core domains are held together on the periphery by the outer juxtamembrane helix (OJMH).|||Membrane|||Mitochondrial inner membrane calcium uniporter that mediates calcium uptake into mitochondria. Constitutes a pore-forming and calcium-conducting subunit. Mitochondrial calcium homeostasis plays key roles in cellular physiology and regulates cell bioenergetics, cytoplasmic calcium signals and activation of cell death pathways.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SENP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7P8|||http://purl.uniprot.org/uniprot/A0A5F8H0Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/13616:FAM189A2 ^@ http://purl.uniprot.org/uniprot/F7E297 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/13616:RIN2 ^@ http://purl.uniprot.org/uniprot/F6XCT8 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/13616:SYNDIG1 ^@ http://purl.uniprot.org/uniprot/F7CAE5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/13616:LOC100027189 ^@ http://purl.uniprot.org/uniprot/F7FK22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CCDC126 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3D2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:CEP170B ^@ http://purl.uniprot.org/uniprot/F6TS07 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/13616:KEG11_p03 ^@ http://purl.uniprot.org/uniprot/Q65CI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:CHST12 ^@ http://purl.uniprot.org/uniprot/F6XP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:FOXJ3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI89|||http://purl.uniprot.org/uniprot/F6WWW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ENTPD6 ^@ http://purl.uniprot.org/uniprot/F7GCQ3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:LOC100018896 ^@ http://purl.uniprot.org/uniprot/F6V6W6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:INTS8 ^@ http://purl.uniprot.org/uniprot/F6Q8M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/13616:MMP27 ^@ http://purl.uniprot.org/uniprot/F6X261 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:TMEM45A ^@ http://purl.uniprot.org/uniprot/F6UIJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/13616:ITPRIP ^@ http://purl.uniprot.org/uniprot/F7FAS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Cell membrane|||Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/13616:LOC100022521 ^@ http://purl.uniprot.org/uniprot/F6SPX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103093843 ^@ http://purl.uniprot.org/uniprot/F7BK23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:ARPC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9Z5|||http://purl.uniprot.org/uniprot/F6VZK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Cell projection|||Component of the Arp2/3 complex composed of ARP2, ARP3, ARPC1B/p41-ARC, ARPC2/p34-ARC, ARPC3/p21-ARC, ARPC4/p20-ARC and ARPC5/p16-ARC. Interacts with SHANK3; the interaction probably mediates the association of SHANK3 with the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/13616:TSPAN14 ^@ http://purl.uniprot.org/uniprot/F7E616 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:GPN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/13616:DLX1 ^@ http://purl.uniprot.org/uniprot/F7BRI6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CASP16 ^@ http://purl.uniprot.org/uniprot/F7BTN7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:MTX1 ^@ http://purl.uniprot.org/uniprot/F6V427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CTDP1 ^@ http://purl.uniprot.org/uniprot/F7B931 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CD53 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:IFT20 ^@ http://purl.uniprot.org/uniprot/F6RDW6 ^@ Subcellular Location Annotation ^@ centriole|||cilium|||cis-Golgi network http://togogenome.org/gene/13616:LOC100021363 ^@ http://purl.uniprot.org/uniprot/F6PZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRMT13 ^@ http://purl.uniprot.org/uniprot/F7B009 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/13616:RUVBL1 ^@ http://purl.uniprot.org/uniprot/F7CL07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/13616:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A5F8GVW3|||http://purl.uniprot.org/uniprot/A0A5F8H473|||http://purl.uniprot.org/uniprot/F7BCU1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:KCNU1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWM2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PHB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Cell membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100024614 ^@ http://purl.uniprot.org/uniprot/F6SC37 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:MAATS1 ^@ http://purl.uniprot.org/uniprot/F6PGW3 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/13616:LOC100023588 ^@ http://purl.uniprot.org/uniprot/F6Q1P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:REXO4 ^@ http://purl.uniprot.org/uniprot/F7DY31 ^@ Similarity ^@ Belongs to the REXO4 family. http://togogenome.org/gene/13616:SIGMAR1 ^@ http://purl.uniprot.org/uniprot/F7GIA4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG2 family.|||Cytoplasmic vesicle|||Endoplasmic reticulum membrane|||Functions in lipid transport from the endoplasmic reticulum and is involved in a wide array of cellular functions probably through regulation of the biogenesis of lipid microdomains at the plasma membrane. Regulates calcium efflux at the endoplasmic reticulum.|||Homotrimer.|||Lipid droplet|||Membrane|||Nucleus envelope|||Nucleus inner membrane|||Nucleus outer membrane|||Postsynaptic density membrane|||The C-terminal helices form a flat, hydrophobic surface that is probably tightly associated with the cytosolic surface of the endoplasmic reticulum membrane.|||Vesicle http://togogenome.org/gene/13616:HOXD12 ^@ http://purl.uniprot.org/uniprot/F6ZN53 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:AKIRIN1 ^@ http://purl.uniprot.org/uniprot/F6Y5Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/13616:FAM173A ^@ http://purl.uniprot.org/uniprot/A0A5F8GHD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/13616:VN2R635 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIB4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103103995 ^@ http://purl.uniprot.org/uniprot/K7E1P4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:ACTN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFJ7|||http://purl.uniprot.org/uniprot/A0A5F8GZK7|||http://purl.uniprot.org/uniprot/A0A5F8H0X0|||http://purl.uniprot.org/uniprot/F7DTH8 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/13616:LOC100019389 ^@ http://purl.uniprot.org/uniprot/F6WYU4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:B3GNT2 ^@ http://purl.uniprot.org/uniprot/F6YY27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:SLC5A7 ^@ http://purl.uniprot.org/uniprot/F7DI96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:STX6 ^@ http://purl.uniprot.org/uniprot/F7EKN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Golgi apparatus membrane http://togogenome.org/gene/13616:MYCBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GN05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/13616:LOC103096762 ^@ http://purl.uniprot.org/uniprot/F7FKV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.|||Cell membrane|||Cytoplasm|||Monomer. Interacts with MMP14.|||Nucleus http://togogenome.org/gene/13616:SEMA6A ^@ http://purl.uniprot.org/uniprot/A0A5F8GI43|||http://purl.uniprot.org/uniprot/A0A5F8H6Z1|||http://purl.uniprot.org/uniprot/F6RM83 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VN2R528 ^@ http://purl.uniprot.org/uniprot/F6Z9G8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CEP57 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3Z7 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/13616:SPEN ^@ http://purl.uniprot.org/uniprot/A0A5F8G4M9|||http://purl.uniprot.org/uniprot/A0A5F8GNF5|||http://purl.uniprot.org/uniprot/A0A5F8HDC4|||http://purl.uniprot.org/uniprot/F6VQG1 ^@ Similarity ^@ Belongs to the RRM Spen family. http://togogenome.org/gene/13616:SLC7A6OS ^@ http://purl.uniprot.org/uniprot/F6YQ55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWR1/SLC7A6OS family.|||Cytoplasm|||Directs RNA polymerase II nuclear import.|||Nucleus http://togogenome.org/gene/13616:IL10 ^@ http://purl.uniprot.org/uniprot/F6UHB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-10 family.|||Immune regulatory cytokine.|||Secreted http://togogenome.org/gene/13616:LOC100013238 ^@ http://purl.uniprot.org/uniprot/F6S9U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. In liver microsomes, this enzyme is involved in an NADPH-dependent electron transport pathway. It oxidizes a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:EBAG9 ^@ http://purl.uniprot.org/uniprot/F6VMB3 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/13616:VN2R623 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK40 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ACAA1 ^@ http://purl.uniprot.org/uniprot/F6XXA9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/13616:CLTA ^@ http://purl.uniprot.org/uniprot/A0A5F8GSR6|||http://purl.uniprot.org/uniprot/A0A5F8HAV6|||http://purl.uniprot.org/uniprot/F7G4M4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/13616:PLLP ^@ http://purl.uniprot.org/uniprot/F7DRN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ANXA9 ^@ http://purl.uniprot.org/uniprot/F6YYM0 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/13616:SLITRK3 ^@ http://purl.uniprot.org/uniprot/F7BHD9 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:MAOA ^@ http://purl.uniprot.org/uniprot/A0A5F8GC14|||http://purl.uniprot.org/uniprot/F6UIG4 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/13616:FAM199X ^@ http://purl.uniprot.org/uniprot/F6W884 ^@ Similarity ^@ Belongs to the FAM199 family. http://togogenome.org/gene/13616:SLC25A32 ^@ http://purl.uniprot.org/uniprot/F7F3L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6H2|||http://purl.uniprot.org/uniprot/F6QNX2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:PDGFD ^@ http://purl.uniprot.org/uniprot/F7F7V7 ^@ Caution|||Similarity|||Subunit ^@ Belongs to the PDGF/VEGF growth factor family.|||Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPL4 ^@ http://purl.uniprot.org/uniprot/F6QS92 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL4 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/13616:TLCD1 ^@ http://purl.uniprot.org/uniprot/F6RZ31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SEC61B ^@ http://purl.uniprot.org/uniprot/F6VXR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/13616:CERCAM ^@ http://purl.uniprot.org/uniprot/F6SKY7 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/13616:NUBPL ^@ http://purl.uniprot.org/uniprot/F6Y1Q6 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/13616:LOC100011028 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ZNF408 ^@ http://purl.uniprot.org/uniprot/F6W5U6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ACTBL2 ^@ http://purl.uniprot.org/uniprot/F6ZZG9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:PYROXD1 ^@ http://purl.uniprot.org/uniprot/F6ZXZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. PYROXD1 subfamily.|||sarcomere http://togogenome.org/gene/13616:MFSD10 ^@ http://purl.uniprot.org/uniprot/F7DUZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SLC46A1 ^@ http://purl.uniprot.org/uniprot/F6QTF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100030231 ^@ http://purl.uniprot.org/uniprot/F6W5P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NME4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1F6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/13616:PRMT5 ^@ http://purl.uniprot.org/uniprot/F7A260 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA).|||Belongs to the class I-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SEMA4B ^@ http://purl.uniprot.org/uniprot/F6VD85 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100022501 ^@ http://purl.uniprot.org/uniprot/F6RT32 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Membrane|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/13616:FAM53C ^@ http://purl.uniprot.org/uniprot/A0A5F8H9N6 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/13616:DUSP27 ^@ http://purl.uniprot.org/uniprot/F7B956 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:PIR ^@ http://purl.uniprot.org/uniprot/F6WHS7 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/13616:VKORC1L1 ^@ http://purl.uniprot.org/uniprot/F7E466 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC103094087 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN60|||http://purl.uniprot.org/uniprot/F6ZJL2 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/13616:LOC100013602 ^@ http://purl.uniprot.org/uniprot/F7D2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:FAM83B ^@ http://purl.uniprot.org/uniprot/A0A5F8G730 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/13616:LOC100013589 ^@ http://purl.uniprot.org/uniprot/F7EEM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:TMC5 ^@ http://purl.uniprot.org/uniprot/F6RPV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/13616:SLC6A19 ^@ http://purl.uniprot.org/uniprot/F7A6R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:DNAAF1 ^@ http://purl.uniprot.org/uniprot/F7ATT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||cilium http://togogenome.org/gene/13616:PPM1B ^@ http://purl.uniprot.org/uniprot/F6WMG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/13616:ZC3H14 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZC3H14 family.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/13616:SNTB1 ^@ http://purl.uniprot.org/uniprot/F7CVW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/13616:LRP10 ^@ http://purl.uniprot.org/uniprot/F6ZCI9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PRDM4 ^@ http://purl.uniprot.org/uniprot/F7BBW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CC2D1B ^@ http://purl.uniprot.org/uniprot/F6W5J6 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/13616:PDK3 ^@ http://purl.uniprot.org/uniprot/F7EDV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/13616:SLC27A2 ^@ http://purl.uniprot.org/uniprot/F6YDA1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:GOLT1B ^@ http://purl.uniprot.org/uniprot/A0A5F8GGP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/13616:SLC35B3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZN9|||http://purl.uniprot.org/uniprot/F6TTM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/13616:AFF1 ^@ http://purl.uniprot.org/uniprot/F7G971 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/13616:FGF14 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBK8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:LOC100020945 ^@ http://purl.uniprot.org/uniprot/F6TES4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:SEC62 ^@ http://purl.uniprot.org/uniprot/F7CA52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:UBE2A ^@ http://purl.uniprot.org/uniprot/F6SAT6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:MRPS21 ^@ http://purl.uniprot.org/uniprot/F7AD79 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/13616:SEC24D ^@ http://purl.uniprot.org/uniprot/F7G0E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:LOC100022336 ^@ http://purl.uniprot.org/uniprot/F7GF25 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/13616:GRB10 ^@ http://purl.uniprot.org/uniprot/F6YZ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/13616:TMEM254 ^@ http://purl.uniprot.org/uniprot/F7D4D9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LDB3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDP9|||http://purl.uniprot.org/uniprot/F6ZAK9 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/13616:ABCG4 ^@ http://purl.uniprot.org/uniprot/F7D9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/13616:CDNF ^@ http://purl.uniprot.org/uniprot/A0A5F8GGW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/13616:ZNF488 ^@ http://purl.uniprot.org/uniprot/F6WMS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CASK ^@ http://purl.uniprot.org/uniprot/A0A5F8GLR6|||http://purl.uniprot.org/uniprot/A0A5F8GN34 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/13616:GALK2 ^@ http://purl.uniprot.org/uniprot/F7EGU0 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/13616:CATSPERD ^@ http://purl.uniprot.org/uniprot/F6XVR8 ^@ Similarity ^@ Belongs to the CATSPERD family. http://togogenome.org/gene/13616:NPRL2 ^@ http://purl.uniprot.org/uniprot/F7G4N3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/13616:CLDN7 ^@ http://purl.uniprot.org/uniprot/F6ZWR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:MRPL9 ^@ http://purl.uniprot.org/uniprot/F7CQD1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/13616:GPR3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:POLG2 ^@ http://purl.uniprot.org/uniprot/F7FAA1 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/13616:MDH1 ^@ http://purl.uniprot.org/uniprot/F6PLH7 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/13616:METTL15 ^@ http://purl.uniprot.org/uniprot/F7FNK2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/13616:C2H1orf27 ^@ http://purl.uniprot.org/uniprot/F6YEE1 ^@ Function|||Similarity ^@ Belongs to the ODR-4 family.|||May play a role in the trafficking of a subset of G-protein coupled receptors. http://togogenome.org/gene/13616:CLN3 ^@ http://purl.uniprot.org/uniprot/F6Z665 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:PSMC5 ^@ http://purl.uniprot.org/uniprot/F6VUJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/13616:NCOA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWH9|||http://purl.uniprot.org/uniprot/F6ZNG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/13616:LOC100009811 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI45 ^@ Similarity ^@ Belongs to the CLCR family. http://togogenome.org/gene/13616:SLC7A3 ^@ http://purl.uniprot.org/uniprot/F7ASW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100012932 ^@ http://purl.uniprot.org/uniprot/F6VWW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:IL4R ^@ http://purl.uniprot.org/uniprot/K7E6C0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:YIPF2 ^@ http://purl.uniprot.org/uniprot/F6XWH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/13616:TMED6 ^@ http://purl.uniprot.org/uniprot/F6YGQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100014136 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYJ8|||http://purl.uniprot.org/uniprot/A0A5F8H6G7|||http://purl.uniprot.org/uniprot/F7BW30 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/13616:ATXN7L3 ^@ http://purl.uniprot.org/uniprot/F7DF88 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ENY2 and USP22.|||Component of the transcription regulatory histone acetylation (HAT) complex SAGA, a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. Within the complex, it is required to recruit USP22 and ENY2 into the SAGA complex. Regulates H2B monoubiquitination (H2Bub1) levels. Affects subcellular distribution of ENY2, USP22 and ATXN7L3B.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of USP22 forms the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/13616:GUCY2C ^@ http://purl.uniprot.org/uniprot/F7B751 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/13616:YAE1D1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI68 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100022683 ^@ http://purl.uniprot.org/uniprot/F6ZCG0 ^@ Function|||Similarity ^@ Belongs to the MFAP1 family.|||Involved in pre-mRNA splicing as a component of the spliceosome. http://togogenome.org/gene/13616:CTPS1 ^@ http://purl.uniprot.org/uniprot/F6WFF7 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/13616:CSTF3 ^@ http://purl.uniprot.org/uniprot/F6X9G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UGGT2 ^@ http://purl.uniprot.org/uniprot/F7CUX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:ASIP ^@ http://purl.uniprot.org/uniprot/F6YH41 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:KLC4 ^@ http://purl.uniprot.org/uniprot/F7FP03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/13616:TFEC ^@ http://purl.uniprot.org/uniprot/F7DUX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/13616:TEX10 ^@ http://purl.uniprot.org/uniprot/F6S2L8 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/13616:PIGB ^@ http://purl.uniprot.org/uniprot/F7D579 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third alpha-1,2-mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/13616:PLD4 ^@ http://purl.uniprot.org/uniprot/F6TEV9 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/13616:NTS ^@ http://purl.uniprot.org/uniprot/A0A5F8HD06|||http://purl.uniprot.org/uniprot/F7F526 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/13616:DPYSL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT34|||http://purl.uniprot.org/uniprot/F6URW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Cytoplasm|||Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration.|||growth cone http://togogenome.org/gene/13616:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4J0|||http://purl.uniprot.org/uniprot/A0A5F8GMK6|||http://purl.uniprot.org/uniprot/A0A5F8HDP1|||http://purl.uniprot.org/uniprot/F7GEU5 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/13616:ITGB5 ^@ http://purl.uniprot.org/uniprot/F6PPW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/13616:DAPK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHC4|||http://purl.uniprot.org/uniprot/F7CSM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:VN2R645 ^@ http://purl.uniprot.org/uniprot/F7BFX0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ELF3 ^@ http://purl.uniprot.org/uniprot/F6XM40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:LOC100024828 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8B7 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/13616:CLGN ^@ http://purl.uniprot.org/uniprot/F6XSA8 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/13616:SLC25A19 ^@ http://purl.uniprot.org/uniprot/F7EF03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:GNG5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:GPATCH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLY7 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/13616:DNAJC18 ^@ http://purl.uniprot.org/uniprot/F7CB96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SPDEF ^@ http://purl.uniprot.org/uniprot/F6SVC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:RORA ^@ http://purl.uniprot.org/uniprot/F6QXD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100027035 ^@ http://purl.uniprot.org/uniprot/F6PJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RPL38 ^@ http://purl.uniprot.org/uniprot/F7FFK1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/13616:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYZ9|||http://purl.uniprot.org/uniprot/F7AL23 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SRC ^@ http://purl.uniprot.org/uniprot/A0A5F8GEV3|||http://purl.uniprot.org/uniprot/A0A5F8GUX0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:LOC100013728 ^@ http://purl.uniprot.org/uniprot/A0A5F8H486 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ALG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate.|||Membrane http://togogenome.org/gene/13616:NADK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBQ7|||http://purl.uniprot.org/uniprot/F7FK96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAD kinase family.|||Homodimer.|||Mitochondrial NAD(+) kinase that phosphorylates NAD(+) to yield NADP(+). Can use both ATP or inorganic polyphosphate as the phosphoryl donor.|||Mitochondrion http://togogenome.org/gene/13616:FTSJ3 ^@ http://purl.uniprot.org/uniprot/F6UUX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Interacts with NIP7.|||Probable methyltransferase involved in the processing of the 34S pre-rRNA to 18S rRNA and in 40S ribosomal subunit formation.|||nucleolus http://togogenome.org/gene/13616:KCNQ2 ^@ http://purl.uniprot.org/uniprot/F6WQP9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103093927 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKH0 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/13616:BANF1 ^@ http://purl.uniprot.org/uniprot/F7GCP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CNNM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAK4|||http://purl.uniprot.org/uniprot/F7G0P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Membrane http://togogenome.org/gene/13616:LYPLA2 ^@ http://purl.uniprot.org/uniprot/F6ZPC7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/13616:ISCU ^@ http://purl.uniprot.org/uniprot/A0A5F8G6L9|||http://purl.uniprot.org/uniprot/F6UVD9 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/13616:TSHR ^@ http://purl.uniprot.org/uniprot/F7AAI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/13616:LOC100024463 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDIA3 ^@ http://purl.uniprot.org/uniprot/F7E4L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/F6ZL24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:TPP1 ^@ http://purl.uniprot.org/uniprot/F7FRR4 ^@ Cofactor ^@ Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/13616:CC2D1A ^@ http://purl.uniprot.org/uniprot/F7CV27 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/13616:GADD45G ^@ http://purl.uniprot.org/uniprot/F7G7J2 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/13616:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/F7DI08 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/13616:SPARC ^@ http://purl.uniprot.org/uniprot/A0A5F8HE45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/13616:LOC100015831 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAI6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:AKAP4 ^@ http://purl.uniprot.org/uniprot/F6PK57 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/13616:SLURP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NCEH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3H2 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:EMSY ^@ http://purl.uniprot.org/uniprot/A0A5F8GFH5|||http://purl.uniprot.org/uniprot/A0A5F8GY23|||http://purl.uniprot.org/uniprot/A0A5F8H3J3|||http://purl.uniprot.org/uniprot/A0A5F8HI90|||http://purl.uniprot.org/uniprot/F7DM87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MFSD8 ^@ http://purl.uniprot.org/uniprot/F6YG84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TEC ^@ http://purl.uniprot.org/uniprot/F7EN79 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:TMED10 ^@ http://purl.uniprot.org/uniprot/F6WFY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:FAM172A ^@ http://purl.uniprot.org/uniprot/A0A5F8GGE2|||http://purl.uniprot.org/uniprot/A0A5F8H6J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM172 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:NSFL1C ^@ http://purl.uniprot.org/uniprot/A0A5F8GFM0 ^@ Subcellular Location Annotation|||Subunit ^@ Golgi stack|||Part of a ternary complex containing STX5A, NSFL1C and VCP. NSFL1C forms a homotrimer that binds to one end of a VCP homohexamer. The complex binds to membranes enriched in phosphatidylethanolamine-containing lipids and promotes Golgi membrane fusion. Interaction with VCIP135 leads to dissociation of the complex via ATP hydrolysis by VCP. Binds ubiquitin and mono-ubiquitinated proteins via its N-terminal UBA-like domain when bound to VCP. http://togogenome.org/gene/13616:ATP8A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G638|||http://purl.uniprot.org/uniprot/A0A5F8G7E0|||http://purl.uniprot.org/uniprot/A0A5F8GPA3|||http://purl.uniprot.org/uniprot/F7A161 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:PIK3C3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||Midbody http://togogenome.org/gene/13616:MCL1 ^@ http://purl.uniprot.org/uniprot/F6ZMX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||nucleoplasm http://togogenome.org/gene/13616:LOC103095046 ^@ http://purl.uniprot.org/uniprot/F7CK00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Component of the 40S small ribosomal subunit.|||Rough endoplasmic reticulum http://togogenome.org/gene/13616:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/F7F6P3 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/13616:KIF7 ^@ http://purl.uniprot.org/uniprot/F6UTW0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:RPL3L ^@ http://purl.uniprot.org/uniprot/F7EB35 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/13616:ACTG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD69 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:LOC100026196 ^@ http://purl.uniprot.org/uniprot/F6YF10 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:VEGFC ^@ http://purl.uniprot.org/uniprot/F6ZK49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/13616:CHMP1A ^@ http://purl.uniprot.org/uniprot/A0A5F8GJP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF7 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:IFRD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Z6|||http://purl.uniprot.org/uniprot/F7CY73 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/13616:RALB ^@ http://purl.uniprot.org/uniprot/F6WB97 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/13616:EXOSC2 ^@ http://purl.uniprot.org/uniprot/F7FU90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/13616:HAL ^@ http://purl.uniprot.org/uniprot/F7CKM9 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/13616:GBGT1 ^@ http://purl.uniprot.org/uniprot/F6VXM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/13616:DPM1 ^@ http://purl.uniprot.org/uniprot/F6XRX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/13616:RPS6KA5 ^@ http://purl.uniprot.org/uniprot/F7FUC1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/13616:LOC100030512 ^@ http://purl.uniprot.org/uniprot/F7FFU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC103094341 ^@ http://purl.uniprot.org/uniprot/K7E123 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:RBPJL ^@ http://purl.uniprot.org/uniprot/F7FYG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/13616:SLC25A35 ^@ http://purl.uniprot.org/uniprot/F7E9T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:B4GALT1 ^@ http://purl.uniprot.org/uniprot/F7C2S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:DSCR3 ^@ http://purl.uniprot.org/uniprot/F6S556 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/13616:WBP4 ^@ http://purl.uniprot.org/uniprot/F7GGY7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ATP5G3 ^@ http://purl.uniprot.org/uniprot/F7EV18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/13616:PKN3 ^@ http://purl.uniprot.org/uniprot/F6TSX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Nucleus http://togogenome.org/gene/13616:RBM22 ^@ http://purl.uniprot.org/uniprot/F7AX36 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/13616:CNIH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/13616:B4GALT3 ^@ http://purl.uniprot.org/uniprot/F6ZCN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:CLCN7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJW9|||http://purl.uniprot.org/uniprot/F6PY30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/13616:MAGI3 ^@ http://purl.uniprot.org/uniprot/F7AV49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:TECRL ^@ http://purl.uniprot.org/uniprot/F7ANT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/13616:LOC100028608 ^@ http://purl.uniprot.org/uniprot/F6SAU5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:RRM2B ^@ http://purl.uniprot.org/uniprot/F6SL91 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/13616:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/F7E9M6 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/13616:DDR2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9N5|||http://purl.uniprot.org/uniprot/F7D3Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100012514 ^@ http://purl.uniprot.org/uniprot/F6SSU7 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:VN2R619 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0K8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SNAP47 ^@ http://purl.uniprot.org/uniprot/F6X6M3 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/13616:BAX ^@ http://purl.uniprot.org/uniprot/F6XQQ4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:PSMB7 ^@ http://purl.uniprot.org/uniprot/F6WNU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB7 displays a trypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is a barrel-shaped complex made of 28 subunits that are arranged in four stacked rings. The two outer rings are each formed by seven alpha subunits, and the two inner rings are formed by seven beta subunits. The proteolytic activity is exerted by three beta-subunits PSMB5, PSMB6 and PSMB7. http://togogenome.org/gene/13616:SLC35F1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/13616:TMCC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF74|||http://purl.uniprot.org/uniprot/F6WZC2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/13616:LOC100032945 ^@ http://purl.uniprot.org/uniprot/F7DU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/13616:IGFBP1 ^@ http://purl.uniprot.org/uniprot/F6XGI9 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds equally well IGF1 and IGF2.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors. Promotes cell migration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LIN54 ^@ http://purl.uniprot.org/uniprot/F6YAP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/13616:ERG ^@ http://purl.uniprot.org/uniprot/A0A5F8GRC5|||http://purl.uniprot.org/uniprot/F6S580 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:GPC1 ^@ http://purl.uniprot.org/uniprot/F7FML1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate.|||extracellular space http://togogenome.org/gene/13616:LOC100016601 ^@ http://purl.uniprot.org/uniprot/F7EU36 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:MRPL50 ^@ http://purl.uniprot.org/uniprot/F6RH12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/13616:SMIM8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/13616:PIGF ^@ http://purl.uniprot.org/uniprot/A0A5F8HD39 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:KDSR ^@ http://purl.uniprot.org/uniprot/F7GGW4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:SLC35E3 ^@ http://purl.uniprot.org/uniprot/F6WCA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CUL3 ^@ http://purl.uniprot.org/uniprot/F6UH62 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:SNX4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5M8|||http://purl.uniprot.org/uniprot/F6QVT1 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/F7CUT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:CEP57L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GND6|||http://purl.uniprot.org/uniprot/A0A5F8HFG1 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/13616:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN51|||http://purl.uniprot.org/uniprot/F6UQK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:ISY1 ^@ http://purl.uniprot.org/uniprot/F7CDJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/13616:EIF3E ^@ http://purl.uniprot.org/uniprot/F6ZC02 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with COPS3, COPS6, COPS7 (COPS7A or COPS7B), EIF4G1, EPAS1, MCM7, NCBP1, PSMC6, TRIM27 and UPF2.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression. Required for nonsense-mediated mRNA decay (NMD); may act in conjunction with UPF2 to divert mRNAs from translation to the NMD pathway. May interact with MCM7 and EPAS1 and regulate the proteasome-mediated degradation of these proteins.|||Cytoplasm|||Nucleus|||PML body|||Phosphorylated upon DNA damage, probably by ATM or ATR. http://togogenome.org/gene/13616:TGM2 ^@ http://purl.uniprot.org/uniprot/F6TFD4 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/13616:CHD7 ^@ http://purl.uniprot.org/uniprot/F7G444 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/13616:HPDL ^@ http://purl.uniprot.org/uniprot/F7A0G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 4HPPD family.|||Catalyzes the conversion of 4-hydroxyphenylpyruvic acid to homogentisic acid, one of the steps in tyrosine catabolism.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/13616:LOC100013050 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT56 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:LOC100013114 ^@ http://purl.uniprot.org/uniprot/F6VTP9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:CPA3 ^@ http://purl.uniprot.org/uniprot/F6TIS2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:EDEM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKP9|||http://purl.uniprot.org/uniprot/F6SNH2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:LOC100029982 ^@ http://purl.uniprot.org/uniprot/F6SLF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031129 ^@ http://purl.uniprot.org/uniprot/A0A5F8H461 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CHAC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Z6|||http://purl.uniprot.org/uniprot/F7BBA1 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/13616:PTCD3 ^@ http://purl.uniprot.org/uniprot/F7CQ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/13616:NKX6-1 ^@ http://purl.uniprot.org/uniprot/F6Z980 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100031667 ^@ http://purl.uniprot.org/uniprot/F7GGE6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:PFAS ^@ http://purl.uniprot.org/uniprot/A0A5F8H032 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/13616:IMMT ^@ http://purl.uniprot.org/uniprot/F6RDZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:HADH ^@ http://purl.uniprot.org/uniprot/F6ZBI7 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:KRT4 ^@ http://purl.uniprot.org/uniprot/F6PSM3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:CDX2 ^@ http://purl.uniprot.org/uniprot/F7B348 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/13616:SLC2A8 ^@ http://purl.uniprot.org/uniprot/F6SU86 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/13616:ATP9A ^@ http://purl.uniprot.org/uniprot/F7EQP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:RAE1 ^@ http://purl.uniprot.org/uniprot/F7A424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat rae1 family.|||spindle pole http://togogenome.org/gene/13616:QRFPR ^@ http://purl.uniprot.org/uniprot/F7GB29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:WNT16 ^@ http://purl.uniprot.org/uniprot/F6WWA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:UBE2L3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNU3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:CDCA2 ^@ http://purl.uniprot.org/uniprot/F7D1W5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:HTR1E ^@ http://purl.uniprot.org/uniprot/F6XI83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMX2 ^@ http://purl.uniprot.org/uniprot/F7EA08 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum and mitochondria-associated protein that probably functions as a regulator of cellular redox state and thereby regulates protein post-translational modification, protein folding and mitochondrial activity. Indirectly regulates neuronal proliferation, migration, and organization in the developing brain.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:RAD51 ^@ http://purl.uniprot.org/uniprot/F6WB93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Plays an important role in homologous strand exchange, a key step in DNA repair through homologous recombination (HR). Binds to single-stranded DNA in an ATP-dependent manner to form nucleoprotein filaments which are essential for the homology search and strand exchange. Catalyzes the recognition of homology and strand exchange between homologous DNA partners to form a joint molecule between a processed DNA break and the repair template. Recruited to resolve stalled replication forks during replication stress. Also involved in interstrand cross-link repair. http://togogenome.org/gene/13616:POU4F2 ^@ http://purl.uniprot.org/uniprot/F6X542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/13616:FOXN1 ^@ http://purl.uniprot.org/uniprot/F6QSP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GPHB5 ^@ http://purl.uniprot.org/uniprot/F7GCN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/13616:TUSC5 ^@ http://purl.uniprot.org/uniprot/F6Y8J9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/13616:HMX3 ^@ http://purl.uniprot.org/uniprot/F7G0H2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAM19A4 ^@ http://purl.uniprot.org/uniprot/K7DZQ7 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/13616:YIPF7 ^@ http://purl.uniprot.org/uniprot/F7A0P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/13616:PAQR9 ^@ http://purl.uniprot.org/uniprot/F7DX68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:LOC103096413 ^@ http://purl.uniprot.org/uniprot/F6YQE3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:T2R39 ^@ http://purl.uniprot.org/uniprot/Q2AB88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H125|||http://purl.uniprot.org/uniprot/F6QUX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/13616:DR1 ^@ http://purl.uniprot.org/uniprot/F6UL95 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/13616:LOC100022003 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LAMP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8Y0|||http://purl.uniprot.org/uniprot/F7GE18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/13616:SV2C ^@ http://purl.uniprot.org/uniprot/F6PIT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:LOC100030359 ^@ http://purl.uniprot.org/uniprot/F7CH89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/13616:RNF43 ^@ http://purl.uniprot.org/uniprot/F7D310 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane http://togogenome.org/gene/13616:HOMER2 ^@ http://purl.uniprot.org/uniprot/F6WSQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/13616:GREB1L ^@ http://purl.uniprot.org/uniprot/F7GK85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GREB1 family.|||Membrane http://togogenome.org/gene/13616:ALG14 ^@ http://purl.uniprot.org/uniprot/F6SY28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/13616:AFM ^@ http://purl.uniprot.org/uniprot/F7AX94 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:CD8A ^@ http://purl.uniprot.org/uniprot/I6LJ10 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:GPRC5C ^@ http://purl.uniprot.org/uniprot/A0A5F8HDM6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100028609 ^@ http://purl.uniprot.org/uniprot/F7ET81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100019374 ^@ http://purl.uniprot.org/uniprot/F6Z4P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KCNE1 ^@ http://purl.uniprot.org/uniprot/F7E651 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/13616:ANAPC5 ^@ http://purl.uniprot.org/uniprot/F7ALY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/13616:LOC103098396 ^@ http://purl.uniprot.org/uniprot/F6PJE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:WNT5B ^@ http://purl.uniprot.org/uniprot/A0A5F8GU38|||http://purl.uniprot.org/uniprot/A0A5F8HJT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:KCNH6 ^@ http://purl.uniprot.org/uniprot/F6ZE77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:XYLT1 ^@ http://purl.uniprot.org/uniprot/F6XD49 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 14 family. XylT subfamily.|||Golgi apparatus membrane|||Membrane|||Monomer. http://togogenome.org/gene/13616:CTBP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/13616:SLC16A14 ^@ http://purl.uniprot.org/uniprot/F6U0N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TRAK2 ^@ http://purl.uniprot.org/uniprot/F7B9T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/13616:SEC61A2 ^@ http://purl.uniprot.org/uniprot/F7FIG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:GHRH ^@ http://purl.uniprot.org/uniprot/A0A5F8G7T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/13616:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCN3|||http://purl.uniprot.org/uniprot/F7DHQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/13616:LOC100026693 ^@ http://purl.uniprot.org/uniprot/F7FVE9 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/13616:LOC100018127 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:OIT3 ^@ http://purl.uniprot.org/uniprot/F6YCC1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/F6PM24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/13616:LOC100017912 ^@ http://purl.uniprot.org/uniprot/F6UHN1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MOCS3 ^@ http://purl.uniprot.org/uniprot/F6XRW0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Interacts with NFS1.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers URM1 and MOCS2A. Its N-terminus first activates URM1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/13616:SNX25 ^@ http://purl.uniprot.org/uniprot/F6U6G2 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:LOC100020689 ^@ http://purl.uniprot.org/uniprot/F6S985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100018646 ^@ http://purl.uniprot.org/uniprot/F6W7S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:STEAP3 ^@ http://purl.uniprot.org/uniprot/F6QMH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:TMEM168 ^@ http://purl.uniprot.org/uniprot/F7AGF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane http://togogenome.org/gene/13616:UNC5C ^@ http://purl.uniprot.org/uniprot/F6Q8P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/13616:CUL4A ^@ http://purl.uniprot.org/uniprot/F7G925 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:KCNA5 ^@ http://purl.uniprot.org/uniprot/F7EBU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.5/KCNA5 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ERMN ^@ http://purl.uniprot.org/uniprot/A0A5F8HDM9 ^@ Function|||Subunit ^@ Binds actin.|||Plays a role in cytoskeletal rearrangements during the late wrapping and/or compaction phases of myelinogenesis as well as in maintenance and stability of myelin sheath in the adult. May play an important role in late-stage oligodendroglia maturation, myelin/Ranvier node formation during CNS development, and in the maintenance and plasticity of related structures in the mature CNS. http://togogenome.org/gene/13616:LOC100026649 ^@ http://purl.uniprot.org/uniprot/F7D0I5 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/13616:ART3 ^@ http://purl.uniprot.org/uniprot/F6RZQ4 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/13616:PCYOX1L ^@ http://purl.uniprot.org/uniprot/F6XEG6 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/13616:LOC100010102 ^@ http://purl.uniprot.org/uniprot/F7EIN0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:PLG ^@ http://purl.uniprot.org/uniprot/F7F243 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/13616:ACBD5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H489|||http://purl.uniprot.org/uniprot/F7GEL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/13616:PARK7 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C56 family.|||Membrane raft http://togogenome.org/gene/13616:NQO1 ^@ http://purl.uniprot.org/uniprot/F7CXV7 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/13616:CYP27A1 ^@ http://purl.uniprot.org/uniprot/F6WH61 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:ZCCHC11 ^@ http://purl.uniprot.org/uniprot/A0A5F8G275|||http://purl.uniprot.org/uniprot/A0A5F8GMA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/13616:ABAT ^@ http://purl.uniprot.org/uniprot/F6XY07 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/13616:ERCC3 ^@ http://purl.uniprot.org/uniprot/F7FQP6 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/13616:NDEL1 ^@ http://purl.uniprot.org/uniprot/F7CL14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/13616:UTP6 ^@ http://purl.uniprot.org/uniprot/F6ZIB6 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/13616:LOC100013915 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDP9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:SRP9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/13616:TCP11 ^@ http://purl.uniprot.org/uniprot/F6X6Q9 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/13616:KCNQ4 ^@ http://purl.uniprot.org/uniprot/F7B5A9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:GJB3 ^@ http://purl.uniprot.org/uniprot/F6TSG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:CD47 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJU7|||http://purl.uniprot.org/uniprot/F6ZW27 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:C4H19orf54 ^@ http://purl.uniprot.org/uniprot/F6TXU5 ^@ Similarity ^@ Belongs to the UPF0692 family. http://togogenome.org/gene/13616:ATP6V0E1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:POLG ^@ http://purl.uniprot.org/uniprot/A0A5F8G911 ^@ Function|||Subcellular Location Annotation ^@ Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/13616:GNB3 ^@ http://purl.uniprot.org/uniprot/F7CXD0 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/13616:LACTB2 ^@ http://purl.uniprot.org/uniprot/F7FC68 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/13616:EPOR ^@ http://purl.uniprot.org/uniprot/F7BUV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HOXD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/F6Z1T7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SLC33A1 ^@ http://purl.uniprot.org/uniprot/F6Z4G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPS4Y1 ^@ http://purl.uniprot.org/uniprot/O62739 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/13616:FAM160A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPI5|||http://purl.uniprot.org/uniprot/F6ZFD7 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/13616:NR1I3 ^@ http://purl.uniprot.org/uniprot/F7A3S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:MPI ^@ http://purl.uniprot.org/uniprot/A0A5F8G5T3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/13616:GIPC1 ^@ http://purl.uniprot.org/uniprot/F7ALU7 ^@ Similarity ^@ Belongs to the GIPC family. http://togogenome.org/gene/13616:ETV4 ^@ http://purl.uniprot.org/uniprot/F7BW11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:HYOU1 ^@ http://purl.uniprot.org/uniprot/F7GJH2 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:KCNC1 ^@ http://purl.uniprot.org/uniprot/F7CX06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100015440 ^@ http://purl.uniprot.org/uniprot/F6R624 ^@ Similarity|||Subunit ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/13616:KCNA2 ^@ http://purl.uniprot.org/uniprot/F6UCV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||lamellipodium membrane|||paranodal septate junction|||synaptosome http://togogenome.org/gene/13616:KCNS2 ^@ http://purl.uniprot.org/uniprot/F7E3Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100010818 ^@ http://purl.uniprot.org/uniprot/A0A5F8G520|||http://purl.uniprot.org/uniprot/A0A5F8G577|||http://purl.uniprot.org/uniprot/A0A5F8GJ50|||http://purl.uniprot.org/uniprot/A0A5F8H9B7|||http://purl.uniprot.org/uniprot/F6ZZC2|||http://purl.uniprot.org/uniprot/K7E3R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/13616:MYF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZT0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:IER5L ^@ http://purl.uniprot.org/uniprot/F7CX31 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/13616:BEST3 ^@ http://purl.uniprot.org/uniprot/F7F684 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/13616:FEZ2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGY6|||http://purl.uniprot.org/uniprot/F6TKQ2 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/13616:CFAP53 ^@ http://purl.uniprot.org/uniprot/F7AAE6 ^@ Similarity ^@ Belongs to the CFAP53 family. http://togogenome.org/gene/13616:PLCB2 ^@ http://purl.uniprot.org/uniprot/F6Y4X0 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/13616:REV1 ^@ http://purl.uniprot.org/uniprot/F7BD34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/13616:ACP7 ^@ http://purl.uniprot.org/uniprot/F7G9N0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/13616:LOC100022248 ^@ http://purl.uniprot.org/uniprot/F6Q020 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ARPC4 ^@ http://purl.uniprot.org/uniprot/F7EQH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Cell projection|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||cytoskeleton http://togogenome.org/gene/13616:SLX4 ^@ http://purl.uniprot.org/uniprot/F7AT45 ^@ Similarity ^@ Belongs to the SLX4 family. http://togogenome.org/gene/13616:GALNT1 ^@ http://purl.uniprot.org/uniprot/F6TU35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100023582 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV83 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:YWHAQ ^@ http://purl.uniprot.org/uniprot/F6ZC14 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:RUNX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEI7 ^@ Function|||Subcellular Location Annotation ^@ Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX.|||Nucleus http://togogenome.org/gene/13616:NKX2-5 ^@ http://purl.uniprot.org/uniprot/F7BSL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NK-2 homeobox family.|||Nucleus http://togogenome.org/gene/13616:LOC100026919 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJ35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:C5H11orf58 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUU7 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/13616:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GET6|||http://purl.uniprot.org/uniprot/A0A5F8GI32|||http://purl.uniprot.org/uniprot/F7DWV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/13616:VPS37C ^@ http://purl.uniprot.org/uniprot/F7FWK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/13616:LOC100021261 ^@ http://purl.uniprot.org/uniprot/F6UGH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/13616:PATL1 ^@ http://purl.uniprot.org/uniprot/F7G829 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/13616:LOC103105183 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF70 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:B9D2 ^@ http://purl.uniprot.org/uniprot/F6PGL5 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/13616:HSF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDN1|||http://purl.uniprot.org/uniprot/F7E523 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/13616:RGS3 ^@ http://purl.uniprot.org/uniprot/F6X2A9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:ODF1 ^@ http://purl.uniprot.org/uniprot/F6XD73 ^@ Function ^@ Component of the outer dense fibers (ODF) of spermatozoa. ODF are filamentous structures located on the outside of the axoneme in the midpiece and principal piece of the mammalian sperm tail and may help to maintain the passive elastic structures and elastic recoil of the sperm tail. http://togogenome.org/gene/13616:E2F8 ^@ http://purl.uniprot.org/uniprot/F7B2W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/13616:ZNF330 ^@ http://purl.uniprot.org/uniprot/F6SZ34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOA36 family.|||nucleolus http://togogenome.org/gene/13616:PAIP2B ^@ http://purl.uniprot.org/uniprot/F6ZAI5 ^@ Similarity ^@ Belongs to the PAIP2 family. http://togogenome.org/gene/13616:DDOST ^@ http://purl.uniprot.org/uniprot/F7FDG3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/13616:FAM131A ^@ http://purl.uniprot.org/uniprot/F7DEE3 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/13616:GCDH ^@ http://purl.uniprot.org/uniprot/F6V0X1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:SERPINB2 ^@ http://purl.uniprot.org/uniprot/F7CGR3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:RTN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKC7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:MRI1 ^@ http://purl.uniprot.org/uniprot/F7G2V1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGX9|||http://purl.uniprot.org/uniprot/F7DP92 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/13616:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD39 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR67|||http://purl.uniprot.org/uniprot/F7G9H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:PLP1 ^@ http://purl.uniprot.org/uniprot/K7E0W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/13616:CALHM1 ^@ http://purl.uniprot.org/uniprot/F7F4B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:PYCR2 ^@ http://purl.uniprot.org/uniprot/F6WFB0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/13616:EDNRA ^@ http://purl.uniprot.org/uniprot/F6STK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/13616:MAPK14 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJU8|||http://purl.uniprot.org/uniprot/F6YAB9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/13616:SLC25A4 ^@ http://purl.uniprot.org/uniprot/F6UNG8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:GABRA4 ^@ http://purl.uniprot.org/uniprot/F6ZBG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU50|||http://purl.uniprot.org/uniprot/A0A5F8HIJ3|||http://purl.uniprot.org/uniprot/F7FAW0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:POLR3D ^@ http://purl.uniprot.org/uniprot/F7FN65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NIPA1 ^@ http://purl.uniprot.org/uniprot/F6X3I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/13616:POLR1C ^@ http://purl.uniprot.org/uniprot/F7G057 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/13616:LOC100028082 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100618832 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBN6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:ADRB3 ^@ http://purl.uniprot.org/uniprot/F7CIS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. Beta-3 is involved in the regulation of lipolysis and thermogenesis.|||Cell membrane|||Interacts with ARRDC3.|||Membrane http://togogenome.org/gene/13616:XRN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1M1|||http://purl.uniprot.org/uniprot/A0A5F8H4P8 ^@ Function|||Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/13616:LOC100027300 ^@ http://purl.uniprot.org/uniprot/F6V138 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/13616:SCML4 ^@ http://purl.uniprot.org/uniprot/F7AKJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/13616:POLR2J ^@ http://purl.uniprot.org/uniprot/F6VE83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/13616:FAM188A ^@ http://purl.uniprot.org/uniprot/F6TUG9 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/13616:IP6K2 ^@ http://purl.uniprot.org/uniprot/F6UYJ2 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/13616:TNS3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/13616:C2H1orf52 ^@ http://purl.uniprot.org/uniprot/F6WAF9 ^@ Similarity ^@ Belongs to the UPF0690 family. http://togogenome.org/gene/13616:NAA38 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTX9 ^@ Function|||Similarity|||Subunit ^@ Auxillary component of the N-terminal acetyltransferase C (NatC) complex which catalyzes acetylation of N-terminal methionine residues.|||Belongs to the snRNP Sm proteins family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30. http://togogenome.org/gene/13616:FAM136A ^@ http://purl.uniprot.org/uniprot/F6QXV8 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/13616:SFXN3 ^@ http://purl.uniprot.org/uniprot/F7DZH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:LOC100019902 ^@ http://purl.uniprot.org/uniprot/F6SRP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GDPD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH73|||http://purl.uniprot.org/uniprot/A0A5F8GZA7|||http://purl.uniprot.org/uniprot/F6YMM7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/13616:SNCG ^@ http://purl.uniprot.org/uniprot/A0A5F8HL03 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/13616:SRSF5 ^@ http://purl.uniprot.org/uniprot/F6T5A0 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/13616:MTO1 ^@ http://purl.uniprot.org/uniprot/F7GD23 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/13616:CRELD2 ^@ http://purl.uniprot.org/uniprot/F6Z426 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SERPINA10 ^@ http://purl.uniprot.org/uniprot/F7G300 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:THEMIS ^@ http://purl.uniprot.org/uniprot/A0A5F8GUM9|||http://purl.uniprot.org/uniprot/F6YJA9 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/13616:LOC100617777 ^@ http://purl.uniprot.org/uniprot/F7GC32 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Nucleus speckle http://togogenome.org/gene/13616:monDomV1R1274 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NTHL1 ^@ http://purl.uniprot.org/uniprot/F6YUY4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Interacts with YBX1.|||Mitochondrion|||Nucleus http://togogenome.org/gene/13616:LOC100027820 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/13616:RPL22 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Y1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/13616:SLC5A10 ^@ http://purl.uniprot.org/uniprot/F7F7X2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:CDK5RAP1 ^@ http://purl.uniprot.org/uniprot/F6TGF1 ^@ Similarity ^@ Belongs to the methylthiotransferase family. MiaB subfamily. http://togogenome.org/gene/13616:AASDH ^@ http://purl.uniprot.org/uniprot/F7DKF4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:PPP1R15B ^@ http://purl.uniprot.org/uniprot/F7BX77 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/13616:LACE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVS7 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/13616:ZGPAT ^@ http://purl.uniprot.org/uniprot/F6QEZ5 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CHD4/Mi-2; the interaction is direct.|||Nucleus http://togogenome.org/gene/13616:LOC100015779 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1X2|||http://purl.uniprot.org/uniprot/F7BAV0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/13616:ERGIC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/13616:EXO1 ^@ http://purl.uniprot.org/uniprot/F6PWE4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/13616:PABPC1L ^@ http://purl.uniprot.org/uniprot/A0A5F8H1R1|||http://purl.uniprot.org/uniprot/F6TY24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/13616:CACTIN ^@ http://purl.uniprot.org/uniprot/F6PFY9 ^@ Similarity ^@ Belongs to the CACTIN family. http://togogenome.org/gene/13616:PROZ ^@ http://purl.uniprot.org/uniprot/A0A5F8GN67 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GLCE ^@ http://purl.uniprot.org/uniprot/A0A5F8G9F3|||http://purl.uniprot.org/uniprot/A0A5F8GB43 ^@ Similarity ^@ Belongs to the D-glucuronyl C5-epimerase family. http://togogenome.org/gene/13616:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A5F8HKX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/13616:PFKFB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVT7|||http://purl.uniprot.org/uniprot/F6SPM4|||http://purl.uniprot.org/uniprot/K7E1I7 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/13616:TLL1 ^@ http://purl.uniprot.org/uniprot/F7DZV7 ^@ Caution|||Cofactor ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CHMP4B ^@ http://purl.uniprot.org/uniprot/F7EIX3 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G927|||http://purl.uniprot.org/uniprot/F6U7Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||cytosol http://togogenome.org/gene/13616:LOC100020693 ^@ http://purl.uniprot.org/uniprot/F6VGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:PUS10 ^@ http://purl.uniprot.org/uniprot/F7G3Q0 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/13616:LOC103096620 ^@ http://purl.uniprot.org/uniprot/K7E1S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/13616:GALNT12 ^@ http://purl.uniprot.org/uniprot/F6T058 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:SV2A ^@ http://purl.uniprot.org/uniprot/F7DXP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:LOC100030263 ^@ http://purl.uniprot.org/uniprot/F6SQ46 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/13616:AHCY ^@ http://purl.uniprot.org/uniprot/F6Z693 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/13616:MTFR1L ^@ http://purl.uniprot.org/uniprot/F6VAA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/13616:FBXO32 ^@ http://purl.uniprot.org/uniprot/F6RIR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CRYBB3 ^@ http://purl.uniprot.org/uniprot/F7AUT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/13616:TFPI ^@ http://purl.uniprot.org/uniprot/F7C0N5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:PLD5 ^@ http://purl.uniprot.org/uniprot/F6PGF6 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/13616:MPV17L2 ^@ http://purl.uniprot.org/uniprot/F6VFY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/13616:LOC103096099 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7N1|||http://purl.uniprot.org/uniprot/A0A5F8G9B7|||http://purl.uniprot.org/uniprot/A0A5F8HDW3 ^@ Function ^@ Major early eggshell protein. http://togogenome.org/gene/13616:LOC100023149 ^@ http://purl.uniprot.org/uniprot/F6YLC4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:RFFL ^@ http://purl.uniprot.org/uniprot/A0A5F8G6E5|||http://purl.uniprot.org/uniprot/F7EC98 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/13616:monDomV1R1201 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:QPCT ^@ http://purl.uniprot.org/uniprot/F7F2N3 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/13616:MECP2 ^@ http://purl.uniprot.org/uniprot/F6TJ54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CUTA ^@ http://purl.uniprot.org/uniprot/F6YZZ1 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/13616:PPAN ^@ http://purl.uniprot.org/uniprot/F7EPT2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:C4H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A5F8H671 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/13616:LOC100619965 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2K5 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/13616:IER2 ^@ http://purl.uniprot.org/uniprot/F7A538 ^@ Similarity ^@ Belongs to the IER family. http://togogenome.org/gene/13616:LOC103103068 ^@ http://purl.uniprot.org/uniprot/F7B859 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/13616:LOC100015520 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:MRPS26 ^@ http://purl.uniprot.org/uniprot/F7FVQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS26 family.|||Mitochondrion http://togogenome.org/gene/13616:HMGB1 ^@ http://purl.uniprot.org/uniprot/F7EDR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Cell membrane|||Chromosome|||Endoplasmic reticulum-Golgi intermediate compartment|||Secreted http://togogenome.org/gene/13616:PRDM12 ^@ http://purl.uniprot.org/uniprot/F7FUD7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Involved in the positive regulation of histone H3-K9 dimethylation.|||Nucleus http://togogenome.org/gene/13616:MXRA8 ^@ http://purl.uniprot.org/uniprot/F7FD57 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:MRPL47 ^@ http://purl.uniprot.org/uniprot/A0A5F8GC81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL29 family.|||Mitochondrion http://togogenome.org/gene/13616:ORC1 ^@ http://purl.uniprot.org/uniprot/F6QFY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase. Interacts with CDC6 and KAT7/HBO1. Interacts with LRWD1 predominantly during the G1 phase and with less affinity during mitosis, when phosphorylated.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus http://togogenome.org/gene/13616:LOC100031017 ^@ http://purl.uniprot.org/uniprot/F6QJ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/13616:FAM214B ^@ http://purl.uniprot.org/uniprot/F7EUT4 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/13616:SUSD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP09|||http://purl.uniprot.org/uniprot/F7FLA7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:FAM49B ^@ http://purl.uniprot.org/uniprot/A0A5F8G463 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/13616:ERAP1 ^@ http://purl.uniprot.org/uniprot/F7GID7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:SNX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome|||Endosome|||phagosome http://togogenome.org/gene/13616:monDomV1R1241 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FOXF1 ^@ http://purl.uniprot.org/uniprot/F6U913 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RPF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2N5|||http://purl.uniprot.org/uniprot/F7F2B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/13616:ZCCHC17 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHQ1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:FGFBP1 ^@ http://purl.uniprot.org/uniprot/F7DVS2 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/13616:ARHGEF38 ^@ http://purl.uniprot.org/uniprot/F7F3Z6 ^@ Subcellular Location Annotation ^@ Cell junction|||Golgi stack http://togogenome.org/gene/13616:IL15RA ^@ http://purl.uniprot.org/uniprot/A0A5F8HF25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GIF ^@ http://purl.uniprot.org/uniprot/F7FXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/13616:LOC100022691 ^@ http://purl.uniprot.org/uniprot/F6RKE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ENPP4 ^@ http://purl.uniprot.org/uniprot/F7C782 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Cell membrane|||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|||Membrane http://togogenome.org/gene/13616:MRPL35 ^@ http://purl.uniprot.org/uniprot/F7CPF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL35 family.|||Mitochondrion http://togogenome.org/gene/13616:LOC100617205 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100030035 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SLC16A3 ^@ http://purl.uniprot.org/uniprot/F7GBJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/13616:LOC100024810 ^@ http://purl.uniprot.org/uniprot/F6VY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/13616:GRIA1 ^@ http://purl.uniprot.org/uniprot/F7B4C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/13616:LOC100015032 ^@ http://purl.uniprot.org/uniprot/F6VP59 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:LTA4H ^@ http://purl.uniprot.org/uniprot/A0A5F8GN45 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/13616:YPEL3 ^@ http://purl.uniprot.org/uniprot/F7EHP1 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/13616:ZIC3 ^@ http://purl.uniprot.org/uniprot/F6V8L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:RBL2 ^@ http://purl.uniprot.org/uniprot/F6ZM79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/13616:PPAT ^@ http://purl.uniprot.org/uniprot/K7DZI9 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/13616:SHQ1 ^@ http://purl.uniprot.org/uniprot/F7FH73 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/13616:MEMO1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE80 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/13616:ASUN ^@ http://purl.uniprot.org/uniprot/F6ZC79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100010487 ^@ http://purl.uniprot.org/uniprot/F6YEH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:SLC6A4 ^@ http://purl.uniprot.org/uniprot/F6VD16 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|||Synapse|||focal adhesion http://togogenome.org/gene/13616:PDE3B ^@ http://purl.uniprot.org/uniprot/F7FQK6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:CFI ^@ http://purl.uniprot.org/uniprot/A0A5F8HF52|||http://purl.uniprot.org/uniprot/F6R2B1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TRADD ^@ http://purl.uniprot.org/uniprot/F7FRX7 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/13616:B3GNT4 ^@ http://purl.uniprot.org/uniprot/F7CXY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LPAR6 ^@ http://purl.uniprot.org/uniprot/F6ZZ79 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:RAD23B ^@ http://purl.uniprot.org/uniprot/F7ASD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/13616:MBOAT7 ^@ http://purl.uniprot.org/uniprot/F7D7G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GNA15 ^@ http://purl.uniprot.org/uniprot/F7EC94 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/13616:APMAP ^@ http://purl.uniprot.org/uniprot/F7BQY7 ^@ Similarity ^@ Belongs to the strictosidine synthase family. http://togogenome.org/gene/13616:CENPK ^@ http://purl.uniprot.org/uniprot/A0A5F8H2W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/13616:KRT32 ^@ http://purl.uniprot.org/uniprot/F6SRI1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:C3H19orf53 ^@ http://purl.uniprot.org/uniprot/F7G2Q5 ^@ Function|||Similarity ^@ Belongs to the UPF0390 family.|||May have a potential role in hypercalcemia of malignancy. http://togogenome.org/gene/13616:TDRD7 ^@ http://purl.uniprot.org/uniprot/F6PIW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TDRD7 family.|||Component of specific cytoplasmic RNA granules involved in post-transcriptional regulation of specific genes: probably acts by binding to specific mRNAs and regulating their translation. Required for lens transparency during lens development, by regulating translation of genes such as CRYBB3 and HSPB1 in the developing lens. Also required during spermatogenesis.|||Cytoplasm|||Found in a mRNP complex, at least composed of TDRD1, TDRD6, TDRD7 and DDX4. Found in a complex containing CABLES1, CDK16 and CDK17. Interacts with CABLES1, CDK17 and PIWIL1. http://togogenome.org/gene/13616:LOC100024515 ^@ http://purl.uniprot.org/uniprot/F7F0L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TOR1AIP1 ^@ http://purl.uniprot.org/uniprot/F7FE19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/13616:IARS2 ^@ http://purl.uniprot.org/uniprot/F6VRQ6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:SLC26A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Sulfate transporter. May play a role in endochondral bone formation. http://togogenome.org/gene/13616:PKP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBV7|||http://purl.uniprot.org/uniprot/F6S0Z1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/13616:MLLT11 ^@ http://purl.uniprot.org/uniprot/F7CM88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLLT11 family.|||Nucleus|||centrosome http://togogenome.org/gene/13616:POLR3F ^@ http://purl.uniprot.org/uniprot/F7CFH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/13616:HSD17B4 ^@ http://purl.uniprot.org/uniprot/F7CLZ9 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/13616:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A5F8HKH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/13616:VN2R627 ^@ http://purl.uniprot.org/uniprot/F6WGS1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SEPHS1 ^@ http://purl.uniprot.org/uniprot/F6Y2T3 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/13616:LOC100021710 ^@ http://purl.uniprot.org/uniprot/K7E3M5 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:LOC100018556 ^@ http://purl.uniprot.org/uniprot/F6TJB1 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/13616:TBL3 ^@ http://purl.uniprot.org/uniprot/F7FYU7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:ATP1B4 ^@ http://purl.uniprot.org/uniprot/F6SSM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/13616:CDK5R2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8P4 ^@ Similarity|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Heterodimer of a catalytic subunit and a regulatory subunit. http://togogenome.org/gene/13616:LITAF ^@ http://purl.uniprot.org/uniprot/A0A5F8GAB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKR9|||http://purl.uniprot.org/uniprot/A0A5F8HDX5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:CSF3R ^@ http://purl.uniprot.org/uniprot/F6ZY07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/13616:ADIPOR1 ^@ http://purl.uniprot.org/uniprot/F7AV52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:MNAT1 ^@ http://purl.uniprot.org/uniprot/F6PG98 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with CDK7 and cyclin H.|||Nucleus|||Stabilizes the cyclin H-CDK7 complex to form a functional CDK-activating kinase (CAK) enzymatic complex. http://togogenome.org/gene/13616:TM2D3 ^@ http://purl.uniprot.org/uniprot/F7CV01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC103100592 ^@ http://purl.uniprot.org/uniprot/F7G3S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DUS4L ^@ http://purl.uniprot.org/uniprot/F7F6S4 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/13616:LOC100619160 ^@ http://purl.uniprot.org/uniprot/A0A5F8H995 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GATA3 ^@ http://purl.uniprot.org/uniprot/F7BYS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:C6H9orf3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ86 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/13616:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMB5 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/13616:LOC100032185 ^@ http://purl.uniprot.org/uniprot/F6SNI6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/13616:LOC103097109 ^@ http://purl.uniprot.org/uniprot/F7B148 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/13616:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/F7EFU5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:LOC100010620 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEK2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/13616:ERLIN1 ^@ http://purl.uniprot.org/uniprot/F7CJY9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/13616:RGS5 ^@ http://purl.uniprot.org/uniprot/F7G7X1 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/13616:AACS ^@ http://purl.uniprot.org/uniprot/F7EI39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/13616:EIF3H ^@ http://purl.uniprot.org/uniprot/F6RA25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3. Interacts with RNF139; the interaction leads to protein translation inhibitions in a ubiquitination-dependent manner.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/13616:CDO1 ^@ http://purl.uniprot.org/uniprot/F6TXZ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit.|||Catalyzes the oxidation of cysteine to cysteine sulfinic acid with addition of molecular dioxygen. http://togogenome.org/gene/13616:NFYB ^@ http://purl.uniprot.org/uniprot/F6YET9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NFYB/HAP3 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes. NF-Y can function as both an activator and a repressor, depending on its interacting cofactors.|||Heterotrimeric transcription factor composed of three components, NF-YA, NF-YB and NF-YC. NF-YB and NF-YC must interact and dimerize for NF-YA association and DNA binding. Interacts with C1QBP. http://togogenome.org/gene/13616:F13A1 ^@ http://purl.uniprot.org/uniprot/F6VTU1 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/13616:GEMIN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the gemin-2 family.|||Cytoplasm|||Part of the core SMN complex.|||The SMN complex catalyzes the assembly of small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome, and thereby plays an important role in the splicing of cellular pre-mRNAs. http://togogenome.org/gene/13616:MC2R ^@ http://purl.uniprot.org/uniprot/F7CBR7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/13616:LOC100618838 ^@ http://purl.uniprot.org/uniprot/F6Q311 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FAM160A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT78|||http://purl.uniprot.org/uniprot/F7FCT7 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/13616:EIF2S1 ^@ http://purl.uniprot.org/uniprot/F6RU41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/13616:SLC37A1 ^@ http://purl.uniprot.org/uniprot/F6QZ07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Inorganic phosphate and glucose-6-phosphate antiporter. May transport cytoplasmic glucose-6-phosphate into the lumen of the endoplasmic reticulum and translocate inorganic phosphate into the opposite direction. Independent of a lumenal glucose-6-phosphatase. May not play a role in homeostatic regulation of blood glucose levels.|||Membrane http://togogenome.org/gene/13616:NACC2 ^@ http://purl.uniprot.org/uniprot/F7E104 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC6A6 ^@ http://purl.uniprot.org/uniprot/K7E0U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A6 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TXK ^@ http://purl.uniprot.org/uniprot/F6ZAP5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:YPEL2 ^@ http://purl.uniprot.org/uniprot/F7AS66 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/13616:SRRD ^@ http://purl.uniprot.org/uniprot/A0A5F8GPP7 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/13616:LOC103103839 ^@ http://purl.uniprot.org/uniprot/K7E1P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAIF1 family.|||Induces apoptosis.|||Nucleus http://togogenome.org/gene/13616:LOC103104622 ^@ http://purl.uniprot.org/uniprot/F7DI29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/13616:PPP2R5A ^@ http://purl.uniprot.org/uniprot/A0A5F8H6J6 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/13616:MRAP ^@ http://purl.uniprot.org/uniprot/A0A5F8GHV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:RGS4 ^@ http://purl.uniprot.org/uniprot/F7GHB2 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/13616:LOC100015220 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBX2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/13616:ABCB11 ^@ http://purl.uniprot.org/uniprot/F7ETR3 ^@ Subcellular Location Annotation ^@ Endosome http://togogenome.org/gene/13616:LAPTM5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2B0|||http://purl.uniprot.org/uniprot/F6XZB7 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/13616:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9V1|||http://purl.uniprot.org/uniprot/F6YNF0 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/13616:OPA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2C2|||http://purl.uniprot.org/uniprot/A0A5F8HGH0|||http://purl.uniprot.org/uniprot/F7CFA6 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:C2H1orf43 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEY8|||http://purl.uniprot.org/uniprot/A0A5F8HL48 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/13616:RCAN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3C2|||http://purl.uniprot.org/uniprot/A0A5F8HJH5 ^@ Function|||Similarity ^@ Belongs to the RCAN family.|||Inhibits calcineurin-dependent transcriptional responses by binding to the catalytic domain of calcineurin A. Could play a role during central nervous system development. http://togogenome.org/gene/13616:OAT ^@ http://purl.uniprot.org/uniprot/F7D3B5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/13616:CRHBP ^@ http://purl.uniprot.org/uniprot/F6WNR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRF-binding protein family.|||Binds CRF and inactivates it. May prevent inappropriate pituitary-adrenal stimulation in pregnancy.|||Secreted http://togogenome.org/gene/13616:LOC100018312 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP71 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/13616:ACKR4 ^@ http://purl.uniprot.org/uniprot/F7GHG6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:NEUROD6 ^@ http://purl.uniprot.org/uniprot/F7BYF9 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/13616:CHRNA4 ^@ http://purl.uniprot.org/uniprot/F6QGI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:SOD2 ^@ http://purl.uniprot.org/uniprot/F7GJS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/13616:RAB11FIP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ75|||http://purl.uniprot.org/uniprot/F7E6J7 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/13616:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/F7GJ67 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/13616:LOC103103724 ^@ http://purl.uniprot.org/uniprot/K7E235 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/13616:FKBP6 ^@ http://purl.uniprot.org/uniprot/F6WS39 ^@ Function|||Similarity ^@ Belongs to the FKBP6 family.|||Co-chaperone required during spermatogenesis to repress transposable elements and prevent their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and govern the methylation and subsequent repression of transposons. Acts as a co-chaperone via its interaction with HSP90 and is required for the piRNA amplification process, the secondary piRNA biogenesis. May be required together with HSP90 in removal of 16 nucleotide ping-pong by-products from Piwi complexes, possibly facilitating turnover of Piwi complexes. http://togogenome.org/gene/13616:RCL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||Does not have cyclase activity. Plays a role in 40S-ribosomal-subunit biogenesis in the early pre-rRNA processing steps at sites A0, A1 and A2 that are required for proper maturation of the 18S RNA.|||nucleolus http://togogenome.org/gene/13616:L3HYPDH ^@ http://purl.uniprot.org/uniprot/K7E500 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/13616:FOXJ2 ^@ http://purl.uniprot.org/uniprot/F7BV32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:C3H5orf22 ^@ http://purl.uniprot.org/uniprot/F6UM79 ^@ Similarity ^@ Belongs to the UPF0489 family. http://togogenome.org/gene/13616:SYNE3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5L1 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/13616:CLRN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/13616:DMRTA2 ^@ http://purl.uniprot.org/uniprot/F7CJ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/13616:ACAD9 ^@ http://purl.uniprot.org/uniprot/F7GES9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:CCT4 ^@ http://purl.uniprot.org/uniprot/F7B657 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/13616:SOX9 ^@ http://purl.uniprot.org/uniprot/F7E3K1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FRK ^@ http://purl.uniprot.org/uniprot/F6Z7T8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:EXOSC9 ^@ http://purl.uniprot.org/uniprot/F7GJQ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:STOML1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFG7|||http://purl.uniprot.org/uniprot/F7BDY3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/13616:LOC100024961 ^@ http://purl.uniprot.org/uniprot/F6X182 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/13616:TCTA ^@ http://purl.uniprot.org/uniprot/F7CSS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTA family.|||May be required for cellular fusion during osteoclastogenesis.|||Membrane http://togogenome.org/gene/13616:FGD6 ^@ http://purl.uniprot.org/uniprot/F6W6U6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:TATDN2 ^@ http://purl.uniprot.org/uniprot/F7BXM4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/13616:LRRC8C ^@ http://purl.uniprot.org/uniprot/F7G4Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TWF1 ^@ http://purl.uniprot.org/uniprot/F7GD77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/13616:LOC103097444 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100022115 ^@ http://purl.uniprot.org/uniprot/F6R532 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/13616:ATXN10 ^@ http://purl.uniprot.org/uniprot/F7EYF8 ^@ Function|||Similarity ^@ Belongs to the ataxin-10 family.|||Necessary for the survival of cerebellar neurons. Induces neuritogenesis by activating the Ras-MAP kinase pathway. May play a role in the maintenance of a critical intracellular glycosylation level and homeostasis. http://togogenome.org/gene/13616:PRPF31 ^@ http://purl.uniprot.org/uniprot/K7E106 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Cajal body http://togogenome.org/gene/13616:TAF5 ^@ http://purl.uniprot.org/uniprot/F7DL63 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/13616:NEUROD1 ^@ http://purl.uniprot.org/uniprot/F7AUR1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TMEM50B ^@ http://purl.uniprot.org/uniprot/F6V201 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/13616:GAB3 ^@ http://purl.uniprot.org/uniprot/F7EDS3 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/13616:CA7 ^@ http://purl.uniprot.org/uniprot/F6PGF8|||http://purl.uniprot.org/uniprot/F6PGJ3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:ATIC ^@ http://purl.uniprot.org/uniprot/F6Z515 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/13616:KEG11_p01 ^@ http://purl.uniprot.org/uniprot/Q65CI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane|||The cytochrome bc1 complex contains 11 subunits: 3 respiratory subunits (MT-CYB, CYC1 and UQCRFS1), 2 core proteins (UQCRC1 and UQCRC2) and 6 low-molecular weight proteins (UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and a cleavage product of UQCRFS1). This cytochrome bc1 complex then forms a dimer. http://togogenome.org/gene/13616:IRX3 ^@ http://purl.uniprot.org/uniprot/F7FAB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/13616:IL11RA ^@ http://purl.uniprot.org/uniprot/F6ZGE5 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/13616:CMBL ^@ http://purl.uniprot.org/uniprot/F7GD97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/13616:LOC100011560 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDX1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:KCNF1 ^@ http://purl.uniprot.org/uniprot/F7D2C1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MBOAT4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MNX1 ^@ http://purl.uniprot.org/uniprot/F6XG12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ZNF326 ^@ http://purl.uniprot.org/uniprot/F7G549 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/13616:LOC100015637 ^@ http://purl.uniprot.org/uniprot/F6TIE4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:CNOT3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation. Additional complex functions may be a consequence of its influence on mRNA expression. May be involved in metabolic regulation; may be involved in recruitment of the CCR4-NOT complex to deadenylation target mRNAs involved in energy metabolism. Involved in mitotic progression and regulation of the spindle assembly checkpoint by regulating the stability of MAD1L1 mRNA. Can repress transcription and may link the CCR4-NOT complex to transcriptional regulation; the repressive function may involve histone deacetylases. Involved in the maintenance of embryonic stem (ES) cell identity.|||Nucleus|||P-body http://togogenome.org/gene/13616:LOC103102448 ^@ http://purl.uniprot.org/uniprot/K7DZ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/13616:LOC100012668 ^@ http://purl.uniprot.org/uniprot/F7GG98 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/13616:SLC15A1 ^@ http://purl.uniprot.org/uniprot/F7EJN7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/13616:ORC5 ^@ http://purl.uniprot.org/uniprot/F6SM08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GRHL3 ^@ http://purl.uniprot.org/uniprot/F7FQ08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GHA3|||http://purl.uniprot.org/uniprot/A0A5F8HKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/13616:EXOSC1 ^@ http://purl.uniprot.org/uniprot/F6XQF9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:SHROOM4 ^@ http://purl.uniprot.org/uniprot/F7BBG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/13616:UXS1 ^@ http://purl.uniprot.org/uniprot/F7G4Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:DCAF10 ^@ http://purl.uniprot.org/uniprot/F6Q3V3 ^@ Function|||Similarity ^@ Belongs to the WD repeat DCAF10 family.|||May function as a substrate receptor for CUL4-DDB1 E3 ubiquitin-protein ligase complex. http://togogenome.org/gene/13616:FAM219A ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ01 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/13616:TEKT4 ^@ http://purl.uniprot.org/uniprot/F6VNC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/13616:COPS5 ^@ http://purl.uniprot.org/uniprot/F7ETC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||synaptic vesicle http://togogenome.org/gene/13616:VCAN ^@ http://purl.uniprot.org/uniprot/F7CK30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aggrecan/versican proteoglycan family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:HOMEZ ^@ http://purl.uniprot.org/uniprot/F7CZK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UCHL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPB4|||http://purl.uniprot.org/uniprot/A0A5F8HB82 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/13616:SLC35B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/13616:PTPN6 ^@ http://purl.uniprot.org/uniprot/F7CWQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:SLC25A15 ^@ http://purl.uniprot.org/uniprot/A0A5F8H400 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:NKD2 ^@ http://purl.uniprot.org/uniprot/F6S8V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:AMN ^@ http://purl.uniprot.org/uniprot/F7DTU7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RNPEP ^@ http://purl.uniprot.org/uniprot/F6Y513 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:BCKDHA ^@ http://purl.uniprot.org/uniprot/F7DH17 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BCKDHA family.|||Heterotetramer of alpha and beta chains.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/13616:SMARCA5 ^@ http://purl.uniprot.org/uniprot/F6R7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/13616:IQSEC1 ^@ http://purl.uniprot.org/uniprot/F7FG08 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/13616:DDX1 ^@ http://purl.uniprot.org/uniprot/F6VNU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule http://togogenome.org/gene/13616:NCBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NCBP1 family.|||Nucleus http://togogenome.org/gene/13616:MAST3 ^@ http://purl.uniprot.org/uniprot/F6VY61 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/13616:AIF1L ^@ http://purl.uniprot.org/uniprot/A0A5F8HC25 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/13616:CITED2 ^@ http://purl.uniprot.org/uniprot/F6VSF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/13616:FBN1 ^@ http://purl.uniprot.org/uniprot/F7CYW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fibrillin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:NPRL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM85|||http://purl.uniprot.org/uniprot/F6YMK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/13616:ADK ^@ http://purl.uniprot.org/uniprot/A0A5F8GHX5|||http://purl.uniprot.org/uniprot/F6WM42 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/13616:C2H17orf62 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:GNA14 ^@ http://purl.uniprot.org/uniprot/F7G1U7 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/13616:AMBP ^@ http://purl.uniprot.org/uniprot/F7D6H6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Kunitz-type serine protease inhibitor. Has high catalytic efficiency for F10/blood coagulation factor Xa and may act as an anticoagulant by inhibiting prothrombin activation. Inhibits trypsin and mast cell CMA1/chymase and tryptase proteases.|||Mitochondrion inner membrane|||Monomer. Also occurs as a complex with tryptase in mast cells.|||Nucleus membrane|||Secreted http://togogenome.org/gene/13616:LOC100011182 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100018520 ^@ http://purl.uniprot.org/uniprot/F6SJ10 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/13616:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/13616:KRR1 ^@ http://purl.uniprot.org/uniprot/F7A3D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/13616:HTR2B ^@ http://purl.uniprot.org/uniprot/F7G7L7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts (via C-terminus) with MPDZ.|||Membrane|||synaptosome http://togogenome.org/gene/13616:LOC100017133 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBF7|||http://purl.uniprot.org/uniprot/F7ANY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:LSM14A ^@ http://purl.uniprot.org/uniprot/F7ALQ2 ^@ Similarity ^@ Belongs to the LSM14 family. http://togogenome.org/gene/13616:HTR7 ^@ http://purl.uniprot.org/uniprot/F6PWX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PRPH ^@ http://purl.uniprot.org/uniprot/F6UWF7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH72|||http://purl.uniprot.org/uniprot/F7BZR5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/13616:SEC23B ^@ http://purl.uniprot.org/uniprot/F6V3D4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:LOC100027080 ^@ http://purl.uniprot.org/uniprot/F6SRY8 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:MIS18A ^@ http://purl.uniprot.org/uniprot/A0A5F8G4M6 ^@ Function|||Subcellular Location Annotation ^@ Required for recruitment of CENPA to centromeres and normal chromosome segregation during mitosis.|||centromere http://togogenome.org/gene/13616:BLMH ^@ http://purl.uniprot.org/uniprot/F6RU49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cytoplasm http://togogenome.org/gene/13616:SLC23A1 ^@ http://purl.uniprot.org/uniprot/F7FSI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LAPTM4B ^@ http://purl.uniprot.org/uniprot/F6PFS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAPTM4/LAPTM5 transporter family.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||multivesicular body lumen|||multivesicular body membrane http://togogenome.org/gene/13616:SLCO4A1 ^@ http://purl.uniprot.org/uniprot/F7G693 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KCNH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYC7|||http://purl.uniprot.org/uniprot/F6ZK39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. H (Eag) (TC 1.A.1.20) subfamily. Kv11.1/KCNH2 sub-subfamily.|||Membrane http://togogenome.org/gene/13616:RGS1 ^@ http://purl.uniprot.org/uniprot/F7G556 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:PCCA ^@ http://purl.uniprot.org/uniprot/F7AYP6 ^@ Subcellular Location Annotation ^@ Mitochondrion matrix http://togogenome.org/gene/13616:SLC44A4 ^@ http://purl.uniprot.org/uniprot/F7CZL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/13616:DDX49 ^@ http://purl.uniprot.org/uniprot/F7ECS2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:SLC25A31 ^@ http://purl.uniprot.org/uniprot/F7FU45 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:STK11 ^@ http://purl.uniprot.org/uniprot/K7E2U8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/13616:RGS9BP ^@ http://purl.uniprot.org/uniprot/F7EZP3 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/13616:SLC23A3 ^@ http://purl.uniprot.org/uniprot/F6XFG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CAD ^@ http://purl.uniprot.org/uniprot/A0A5F8GK19|||http://purl.uniprot.org/uniprot/F7E0R2 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/13616:HM13 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH85|||http://purl.uniprot.org/uniprot/F6VUW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/13616:PCSK1 ^@ http://purl.uniprot.org/uniprot/F7GI61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/13616:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIR8 ^@ Function|||Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family.|||Protein phosphatase that dephosphorylates AKT family kinase specifically at 'Ser-473', blocking cell cycle progression and promoting cell apoptosis. May play an inhibitory role in glucose uptake by adipocytes. http://togogenome.org/gene/13616:TMPO ^@ http://purl.uniprot.org/uniprot/A0A5F8G4Y9|||http://purl.uniprot.org/uniprot/F6X3L4 ^@ Similarity ^@ Belongs to the LEM family. http://togogenome.org/gene/13616:XPNPEP2 ^@ http://purl.uniprot.org/uniprot/F7EVW3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/13616:CDH20 ^@ http://purl.uniprot.org/uniprot/F7C1R7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC35A4 ^@ http://purl.uniprot.org/uniprot/F6SDG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/13616:MYOZ1 ^@ http://purl.uniprot.org/uniprot/F6WB86 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/13616:ESR1 ^@ http://purl.uniprot.org/uniprot/F7CHI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Binds DNA as a homodimer.|||Nucleus|||The steroid hormones and their receptors are involved in the regulation of eukaryotic gene expression and affect cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/13616:LOC100010915 ^@ http://purl.uniprot.org/uniprot/F7EGS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MDGA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7I5|||http://purl.uniprot.org/uniprot/A0A5F8GJL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031977 ^@ http://purl.uniprot.org/uniprot/F6YJC5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:HOXD9 ^@ http://purl.uniprot.org/uniprot/F7A9F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:KIAA1147 ^@ http://purl.uniprot.org/uniprot/F6VF55 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/13616:SLC13A3 ^@ http://purl.uniprot.org/uniprot/F6TWV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/13616:FAM175B ^@ http://purl.uniprot.org/uniprot/A0A5F8H3A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100015889 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKY3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/13616:TMEM183A ^@ http://purl.uniprot.org/uniprot/F6ZGV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM183 family.|||Membrane http://togogenome.org/gene/13616:KCNK17 ^@ http://purl.uniprot.org/uniprot/A0A5F8G871 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP61|||http://purl.uniprot.org/uniprot/F7DFQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/13616:SNED1 ^@ http://purl.uniprot.org/uniprot/F7B7B4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100030172 ^@ http://purl.uniprot.org/uniprot/F6WED1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:STARD3 ^@ http://purl.uniprot.org/uniprot/F7DZ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/13616:KDM4B ^@ http://purl.uniprot.org/uniprot/A0A5F8G415|||http://purl.uniprot.org/uniprot/F7EPQ5 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/13616:VIP ^@ http://purl.uniprot.org/uniprot/F7FG24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted|||VIP causes vasodilation, lowers arterial blood pressure, stimulates myocardial contractility, increases glycogenolysis and relaxes the smooth muscle of trachea, stomach and gall bladder. http://togogenome.org/gene/13616:NDUFB9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/F7GGS1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/13616:SLC46A2 ^@ http://purl.uniprot.org/uniprot/F6V5F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ODC1 ^@ http://purl.uniprot.org/uniprot/F7G6Y2 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/13616:RAD51D ^@ http://purl.uniprot.org/uniprot/F7ECH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/13616:LOC103094399 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK91 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/13616:LOC100023722 ^@ http://purl.uniprot.org/uniprot/F7AWM0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/13616:LOC100010569 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCI9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/13616:IRAK1BP1 ^@ http://purl.uniprot.org/uniprot/F6XBJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRAK1BP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MNS1 ^@ http://purl.uniprot.org/uniprot/F7EL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/13616:NUCB2 ^@ http://purl.uniprot.org/uniprot/F6XCE7 ^@ Similarity ^@ Belongs to the nucleobindin family. http://togogenome.org/gene/13616:TOPAZ1 ^@ http://purl.uniprot.org/uniprot/K7E306 ^@ Function|||Subcellular Location Annotation ^@ Important for normal spermatogenesis and male fertility. Specifically required for progression to the post-meiotic stages of spermatocyte development. Seems to be necessary for normal expression levels of a number of testis-expressed gene transcripts, although its role in this process is unclear.|||cytosol http://togogenome.org/gene/13616:GC ^@ http://purl.uniprot.org/uniprot/A0A5F8H662 ^@ Function|||Subcellular Location Annotation ^@ Involved in vitamin D transport and storage, scavenging of extracellular G-actin, enhancement of the chemotactic activity of C5 alpha for neutrophils in inflammation and macrophage activation.|||Secreted http://togogenome.org/gene/13616:KDM1A ^@ http://purl.uniprot.org/uniprot/F7D7I0 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/13616:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:SFRP2 ^@ http://purl.uniprot.org/uniprot/F7GHD3 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100016658 ^@ http://purl.uniprot.org/uniprot/F7FR20 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/13616:VN2R644 ^@ http://purl.uniprot.org/uniprot/F7BFK2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PNLDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHL9|||http://purl.uniprot.org/uniprot/F7EE59 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/13616:LOC100013846 ^@ http://purl.uniprot.org/uniprot/F6X1G4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:RHBDF2 ^@ http://purl.uniprot.org/uniprot/F7DQ20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/13616:MTMR10 ^@ http://purl.uniprot.org/uniprot/F7CC74 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/13616:TMEFF1 ^@ http://purl.uniprot.org/uniprot/F7CTI6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CEBPE ^@ http://purl.uniprot.org/uniprot/F6QJH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/13616:GJB5 ^@ http://purl.uniprot.org/uniprot/F7EJS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:CAP2 ^@ http://purl.uniprot.org/uniprot/F7F511 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/13616:RRP8 ^@ http://purl.uniprot.org/uniprot/A0A5F8G639 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Component of the eNoSC complex.|||Essential component of the eNoSC (energy-dependent nucleolar silencing) complex, a complex that mediates silencing of rDNA in response to intracellular energy status and acts by recruiting histone-modifying enzymes. The eNoSC complex is able to sense the energy status of cell: upon glucose starvation, elevation of NAD(+)/NADP(+) ratio activates SIRT1, leading to histone H3 deacetylation followed by dimethylation of H3 at 'Lys-9' (H3K9me2) by SUV39H1 and the formation of silent chromatin in the rDNA locus. In the complex, RRP8 binds to H3K9me2 and probably acts as a methyltransferase.|||nucleolus http://togogenome.org/gene/13616:MRPL3 ^@ http://purl.uniprot.org/uniprot/F7G715 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/13616:LOC100011249 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LGI3 ^@ http://purl.uniprot.org/uniprot/F7AWE8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:LANCL3 ^@ http://purl.uniprot.org/uniprot/F6U2W0 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/13616:SHTN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV46|||http://purl.uniprot.org/uniprot/F7FNL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shootin family.|||axon|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/13616:TMEM106A ^@ http://purl.uniprot.org/uniprot/F7CF63 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/13616:PSMA7 ^@ http://purl.uniprot.org/uniprot/F6WS89 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:TRAF4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY95|||http://purl.uniprot.org/uniprot/F6RYQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/13616:SRPRA ^@ http://purl.uniprot.org/uniprot/K7E5M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:GAA ^@ http://purl.uniprot.org/uniprot/F7GEC6 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8Y3|||http://purl.uniprot.org/uniprot/F7FJJ1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:ABCC8 ^@ http://purl.uniprot.org/uniprot/F6XVA7 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/13616:MSANTD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMY3 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/13616:ADCK4 ^@ http://purl.uniprot.org/uniprot/F6ZGH1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/13616:DCTD ^@ http://purl.uniprot.org/uniprot/F6UWJ2 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/13616:LOC100021972 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXG2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PRIMPOL ^@ http://purl.uniprot.org/uniprot/F6UQC2 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/13616:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4P9|||http://purl.uniprot.org/uniprot/F6SHF0 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/13616:LHFPL1 ^@ http://purl.uniprot.org/uniprot/F6ZDS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:OTX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3F7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SCMH1 ^@ http://purl.uniprot.org/uniprot/F6WVN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/13616:PPIB ^@ http://purl.uniprot.org/uniprot/F7BZB1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/F6R8K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/F6SKX5 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/13616:SEMA5A ^@ http://purl.uniprot.org/uniprot/F6U008 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:DNASE2 ^@ http://purl.uniprot.org/uniprot/F6VJD5 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/13616:NFS1 ^@ http://purl.uniprot.org/uniprot/F7BBK5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/13616:METAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2S0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/13616:METTL2A ^@ http://purl.uniprot.org/uniprot/F6W5L3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/13616:PHOX2B ^@ http://purl.uniprot.org/uniprot/F7A1R1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC2A3 ^@ http://purl.uniprot.org/uniprot/F7BV22 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/13616:PDPR ^@ http://purl.uniprot.org/uniprot/F6ZEM0 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/13616:HMX2 ^@ http://purl.uniprot.org/uniprot/F7GAL2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GDE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB52|||http://purl.uniprot.org/uniprot/F7FE75 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/13616:GPR83 ^@ http://purl.uniprot.org/uniprot/F6SGG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:CMTR1 ^@ http://purl.uniprot.org/uniprot/F7DTG4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with POLR2A (via C-terminus).|||Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1).|||S-adenosyl-L-methionine-dependent methyltransferase that mediates mRNA cap1 2'-O-ribose methylation to the 5'-cap structure of mRNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA and small nuclear RNA (snRNA) to produce m(7)GpppRm (cap1). Displays a preference for cap0 transcripts. Cap1 modification is linked to higher levels of translation. May be involved in the interferon response pathway. http://togogenome.org/gene/13616:CDKN2A ^@ http://purl.uniprot.org/uniprot/O77617|||http://purl.uniprot.org/uniprot/O77618 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Acts as a negative regulator of the proliferation of normal cells by interacting strongly with CDK4 and CDK6. This inhibits their ability to interact with cyclins D and to phosphorylate the retinoblastoma protein (By similarity).|||Belongs to the CDKN2 cyclin-dependent kinase inhibitor family.|||Capable of inducing cell cycle arrest in G1 and G2 phases. Acts as a tumor suppressor. Binds to MDM2 and blocks its nucleocytoplasmic shuttling by sequestering it in the nucleolus. This inhibits the oncogenic action of MDM2 by blocking MDM2-induced degradation of p53 and enhancing p53-dependent transactivation and apoptosis. Also induces G2 arrest and apoptosis in a p53-independent manner by preventing the activation of cyclin B1/CDC2 complexes. Binds to BCL6 and down-regulates BCL6-induced transcriptional repression. Binds to E2F1 and MYC and blocks their transcriptional activator activity but has no effect on MYC transcriptional repression. Binds to TOP1/TOPOI and stimulates its activity. This complex binds to rRNA gene promoters and may play a role in rRNA transcription and/or maturation. Interacts with NPM1/B23 and promotes its polyubiquitination and degradation, thus inhibiting rRNA processing. Plays a role in inhibiting ribosome biogenesis, perhaps by binding to the nucleolar localization sequence of transcription termination factor TTF1, and thereby preventing nucleolar localization of TTF1 (By similarity). Interacts with COMMD1 and promotes its 'Lys63'-linked polyubiquitination. Interacts with UBE2I/UBC9 and enhances sumoylation of a number of its binding partners including MDM2 and E2F1. Binds to HUWE1 and represses its ubiquitin ligase activity. May play a role in controlling cell proliferation and apoptosis during mammary gland development (By similarity).|||Cytoplasm|||Does not interact with cyclins, CDK1, CDK2, CDK4, CDK5 or CDK6. Binds to BCL6, E2F1, HUWE1, MDM2, MYC, NPM1/B23, TOP1/TOPOI and UBE2I/UBC9. Interacts with TBRG1 and COMMD1. Interacts with CDKN2AIP and E4F1. Interacts with CDK5RAP3 and MDM2; form a ternary complex involved in regulation of p53/TP53. Interacts with NOP53; the interaction is direct and promotes ARF nucleoplasmic relocalization and ubiquitin-mediated proteasomal degradation (By similarity). Interacts with TTF1 (via the N-terminal region (NRD) and a C-terminal region); the interaction is direct and inhibits the nucleolar localization of TTF1 (By similarity).|||Expressed predominantly in lung and testis. In the testis, restricted to germ cells in the seminiferous epithelium. Not detected in premeiotic spermatogonia but high levels found in postmeiotic spermatids. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.|||Heterodimer with CDK4 or CDK6. Predominamt P16 complexes contained CDK6. Interacts with CDK4 (both 'T-172'-phosphorylated and non-phosphorylated forms); the interaction inhibits cyclin D-CDK4 kinase activity. Interacts with ISCO2 (By similarity).|||Nucleus|||Produced by alternative initiation at Met-35 of isoform 1.|||The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to cyclin-dependent kinase inhibitor 2A (AC O77617) which is encoded by the same gene.|||The proteins described here are encoded by the gene CDKN2A, but are completely unrelated in terms of sequence and function to tumor suppressor ARF (AC O77618) which is encoded by the same gene.|||Ubiquitinated in normal cells by TRIP12 via the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination at the N-terminus, regardless of the absence of lysine residues. Ubiquitination leads to its proteasomal degradation. In cancer cells, however, TRIP12 is located in a different cell compartment, preventing ubiquitination and degradation.|||Ubiquitously expressed. In the testis, expressed in both somatic and germ cells. Not detected in premeiotic spermatogonia but expressed in both meiotic and postmeiotic cells. In primary tumors, low levels detected in melanocytic hyperplasias. Higher levels found in non-metastatic and metastatic melanomas.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:ATP6V1H ^@ http://purl.uniprot.org/uniprot/A0A5F8HGQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:SYT16 ^@ http://purl.uniprot.org/uniprot/F6RG93 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/13616:LOC100022970 ^@ http://purl.uniprot.org/uniprot/F7FNQ6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ATP13A2 ^@ http://purl.uniprot.org/uniprot/F6YG15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/13616:NOX5 ^@ http://purl.uniprot.org/uniprot/A7E3P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FAM161A ^@ http://purl.uniprot.org/uniprot/A0A5F8HEL8 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/13616:LTBR ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Q0|||http://purl.uniprot.org/uniprot/F7G4F9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCB9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/13616:ASXL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H355|||http://purl.uniprot.org/uniprot/F7CIA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/13616:ASXL1 ^@ http://purl.uniprot.org/uniprot/F6RWS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Asx family.|||Nucleus http://togogenome.org/gene/13616:SNRPD1 ^@ http://purl.uniprot.org/uniprot/F7G2W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP core protein family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP. Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly. Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. May act as a charged protein scaffold to promote snRNP assembly or strengthen snRNP-snRNP interactions through non-specific electrostatic contacts with RNA.|||cytosol http://togogenome.org/gene/13616:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A5F8GUC5|||http://purl.uniprot.org/uniprot/A0A5F8GVQ6|||http://purl.uniprot.org/uniprot/A0A5F8HE05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/13616:MCUR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLK7|||http://purl.uniprot.org/uniprot/A0A5F8GLY0 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/13616:CMPK1 ^@ http://purl.uniprot.org/uniprot/F7AP82 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and CMP as phosphate acceptors. Also displays broad nucleoside diphosphate kinase activity.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/13616:SEH1L ^@ http://purl.uniprot.org/uniprot/A0A5F8GFA8|||http://purl.uniprot.org/uniprot/F7CBH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Component of the Nup107-160 subcomplex of the nuclear pore complex (NPC). The Nup107-160 subcomplex is required for the assembly of a functional NPC. The Nup107-160 subcomplex is also required for normal kinetochore microtubule attachment, mitotic progression and chromosome segregation. This subunit plays a role in recruitment of the Nup107-160 subcomplex to the kinetochore.|||Lysosome membrane|||kinetochore http://togogenome.org/gene/13616:DSTN ^@ http://purl.uniprot.org/uniprot/F7D0S2 ^@ Function|||Similarity ^@ Actin-depolymerizing protein. Severs actin filaments (F-actin) and binds to actin monomers (G-actin). Acts in a pH-independent manner.|||Belongs to the actin-binding proteins ADF family. http://togogenome.org/gene/13616:ANAPC2 ^@ http://purl.uniprot.org/uniprot/F6XXR8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:LOC100015966 ^@ http://purl.uniprot.org/uniprot/F7F9Q2 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/13616:STOM ^@ http://purl.uniprot.org/uniprot/A0A5F8GY80|||http://purl.uniprot.org/uniprot/F6UAH2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/13616:FOXA3 ^@ http://purl.uniprot.org/uniprot/F6WDS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GALNT2 ^@ http://purl.uniprot.org/uniprot/F7B0K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:ENO4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G414 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/13616:APOBEC1 ^@ http://purl.uniprot.org/uniprot/Q9TUI7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 Zn(2+) ion per subunit.|||Catalytic component of the apolipoprotein B mRNA editing enzyme complex which is responsible for the postranscriptional editing of a CAA codon for Gln to a UAA codon for stop in the APOB mRNA. May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation.|||Cytoplasm|||Homodimer. Part of the apolipoprotein B mRNA editing complex with A1CF. Interacts with HNRPAB and SYNCRIP. http://togogenome.org/gene/13616:CDCA8 ^@ http://purl.uniprot.org/uniprot/F7E4K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the borealin family.|||centromere http://togogenome.org/gene/13616:LOC100010333 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX51 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Lysosome|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/13616:NSUN4 ^@ http://purl.uniprot.org/uniprot/F6RHT5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/13616:AGTR2 ^@ http://purl.uniprot.org/uniprot/F7C222 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/13616:CAMK2N2 ^@ http://purl.uniprot.org/uniprot/F7F029 ^@ Similarity ^@ Belongs to the CAMK2N family. http://togogenome.org/gene/13616:WNT10A ^@ http://purl.uniprot.org/uniprot/F6SGX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:DBNL ^@ http://purl.uniprot.org/uniprot/A0A5F8GM57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Cell membrane|||Early endosome|||Endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||Synapse|||cell cortex|||clathrin-coated vesicle membrane|||cytoskeleton|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/13616:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/F7CYB7 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/13616:LOC100020587 ^@ http://purl.uniprot.org/uniprot/F7CSQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/13616:VPS29 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJK1|||http://purl.uniprot.org/uniprot/F6XX15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the retromer cargo-selective complex (CSC). The CSC is believed to be the core functional component of retromer or respective retromer complex variants acting to prevent missorting of selected transmembrane cargo proteins into the lysosomal degradation pathway.|||Belongs to the VPS29 family.|||Endosome membrane http://togogenome.org/gene/13616:TSEN2 ^@ http://purl.uniprot.org/uniprot/F7FEC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/13616:LOC100017091 ^@ http://purl.uniprot.org/uniprot/F6YZH5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/13616:NSMCE1 ^@ http://purl.uniprot.org/uniprot/F6S2Z2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/13616:FAM163B ^@ http://purl.uniprot.org/uniprot/F7CRK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/13616:LOC100032867 ^@ http://purl.uniprot.org/uniprot/K7DZP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:IL6R ^@ http://purl.uniprot.org/uniprot/F6Z3Z1 ^@ Similarity ^@ Belongs to the type I cytokine receptor family. Type 3 subfamily. http://togogenome.org/gene/13616:CADM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNW5 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/13616:PRRC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRRC1 family.|||Golgi apparatus http://togogenome.org/gene/13616:LOC100023923 ^@ http://purl.uniprot.org/uniprot/F6U0H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1230 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NNT ^@ http://purl.uniprot.org/uniprot/F7C0X4 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/13616:GJA8 ^@ http://purl.uniprot.org/uniprot/F7BI06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:PDGFB ^@ http://purl.uniprot.org/uniprot/F7BJK8 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/13616:ITIH2 ^@ http://purl.uniprot.org/uniprot/F7CI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/13616:LOC100029767 ^@ http://purl.uniprot.org/uniprot/F7A7I3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:MRPS31 ^@ http://purl.uniprot.org/uniprot/F6S8D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS31 family.|||Mitochondrion http://togogenome.org/gene/13616:NAPG ^@ http://purl.uniprot.org/uniprot/F7CB23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/13616:BMP6 ^@ http://purl.uniprot.org/uniprot/F6UAT4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:TATDN1 ^@ http://purl.uniprot.org/uniprot/F6SPH7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/13616:SH3GL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GI38|||http://purl.uniprot.org/uniprot/A0A5F8H9K1|||http://purl.uniprot.org/uniprot/F7DXD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Implicated in endocytosis. May recruit other proteins to membranes with high curvature.|||Membrane http://togogenome.org/gene/13616:SLITRK4 ^@ http://purl.uniprot.org/uniprot/F7BG21 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:GABRE ^@ http://purl.uniprot.org/uniprot/F6TKY5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:TMC7 ^@ http://purl.uniprot.org/uniprot/F6ZSR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/13616:CFAP206 ^@ http://purl.uniprot.org/uniprot/F6PUG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme|||cilium basal body http://togogenome.org/gene/13616:LOC103096027 ^@ http://purl.uniprot.org/uniprot/F7FXN7 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:LOC100024559 ^@ http://purl.uniprot.org/uniprot/F6YSJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CETN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJP8 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/13616:NIT1 ^@ http://purl.uniprot.org/uniprot/F7CHA1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/13616:ITGA6 ^@ http://purl.uniprot.org/uniprot/F7GL63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:MON1A ^@ http://purl.uniprot.org/uniprot/F7EIN6 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/13616:APOA4 ^@ http://purl.uniprot.org/uniprot/F6TDB8 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/13616:ITGB1 ^@ http://purl.uniprot.org/uniprot/F7GAX7|||http://purl.uniprot.org/uniprot/K7E435 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Cell membrane|||Melanosome|||Membrane|||Recycling endosome|||invadopodium membrane|||lamellipodium|||ruffle membrane http://togogenome.org/gene/13616:NUP107 ^@ http://purl.uniprot.org/uniprot/F7FQW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/13616:MEPCE ^@ http://purl.uniprot.org/uniprot/F6R6T5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/13616:CDIPT ^@ http://purl.uniprot.org/uniprot/F7AH47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/13616:LOC100032604 ^@ http://purl.uniprot.org/uniprot/K7E5P0 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:SMPD1 ^@ http://purl.uniprot.org/uniprot/F7FD53 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) ions per subunit.|||Converts sphingomyelin to ceramide.|||Secreted http://togogenome.org/gene/13616:GRB7 ^@ http://purl.uniprot.org/uniprot/F6WKI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/13616:HMGCL ^@ http://purl.uniprot.org/uniprot/F6Z184 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/13616:GRIK3 ^@ http://purl.uniprot.org/uniprot/F7CFG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/13616:TMEM123 ^@ http://purl.uniprot.org/uniprot/F7GG72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/13616:VN2R554 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWZ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100010526 ^@ http://purl.uniprot.org/uniprot/F6Q4E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/13616:SLC16A6 ^@ http://purl.uniprot.org/uniprot/F6W8B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GPR50 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ49|||http://purl.uniprot.org/uniprot/A0A5F8GV66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GADL1 ^@ http://purl.uniprot.org/uniprot/F7CF79 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:RPL34 ^@ http://purl.uniprot.org/uniprot/F6ZBY0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/13616:ASCC3 ^@ http://purl.uniprot.org/uniprot/F7FTH1 ^@ Similarity ^@ Belongs to the helicase family. http://togogenome.org/gene/13616:DMRTA1 ^@ http://purl.uniprot.org/uniprot/F7GJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/13616:ADRA1D ^@ http://purl.uniprot.org/uniprot/F6S411 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/13616:B2M ^@ http://purl.uniprot.org/uniprot/F7G5N8|||http://purl.uniprot.org/uniprot/Q864T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta-2-microglobulin family.|||Component of the class I major histocompatibility complex (MHC). Involved in the presentation of peptide antigens to the immune system (By similarity).|||Heterodimer of an alpha chain and a beta chain. Beta-2-microglobulin is the beta-chain of major histocompatibility complex class I molecules (By similarity).|||Secreted http://togogenome.org/gene/13616:GLE1 ^@ http://purl.uniprot.org/uniprot/F7E1Q6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/13616:OAZ1 ^@ http://purl.uniprot.org/uniprot/F6TQ50 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/13616:PLOD2 ^@ http://purl.uniprot.org/uniprot/F6TJE3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:OSBPL6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRY6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:TMEM54 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM54 family.|||Membrane http://togogenome.org/gene/13616:CCNB2 ^@ http://purl.uniprot.org/uniprot/F7CU79 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/13616:CYFIP1 ^@ http://purl.uniprot.org/uniprot/F6XLX5 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/13616:RDX ^@ http://purl.uniprot.org/uniprot/A0A5F8GK37|||http://purl.uniprot.org/uniprot/A0A5F8HFM6|||http://purl.uniprot.org/uniprot/F7E8X5 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/13616:LOC100025850 ^@ http://purl.uniprot.org/uniprot/F6QBV2 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:COQ6 ^@ http://purl.uniprot.org/uniprot/F7AKV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/13616:NEDD9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G302 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/13616:CTNNB1 ^@ http://purl.uniprot.org/uniprot/F6SRK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||adherens junction http://togogenome.org/gene/13616:AMIGO3 ^@ http://purl.uniprot.org/uniprot/F6UY13 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/13616:ROGDI ^@ http://purl.uniprot.org/uniprot/F7AI84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rogdi family.|||Perikaryon|||Presynapse|||synaptic vesicle http://togogenome.org/gene/13616:MLH1 ^@ http://purl.uniprot.org/uniprot/F7GA57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/13616:VN2R506 ^@ http://purl.uniprot.org/uniprot/F6QLA7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TPD52L2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6R7|||http://purl.uniprot.org/uniprot/A0A5F8GEA6|||http://purl.uniprot.org/uniprot/A0A5F8GID4|||http://purl.uniprot.org/uniprot/A0A5F8GW98|||http://purl.uniprot.org/uniprot/F6Y0L9 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/13616:PGAP1 ^@ http://purl.uniprot.org/uniprot/F7CE20 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins. GPI inositol deacylation may important for efficient transport of GPI-anchored proteins from the endoplasmic reticulum to the Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100013013 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ATL2 ^@ http://purl.uniprot.org/uniprot/F7CC99 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/13616:LOC100019460 ^@ http://purl.uniprot.org/uniprot/F7FG79 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:PGR ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ62|||http://purl.uniprot.org/uniprot/F6Y601 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Cytoplasm|||Nucleus|||Steroid hormone receptor involved in the regulation of eukaryotic gene expression which affects cellular proliferation and differentiation in target tissues. http://togogenome.org/gene/13616:IMPDH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE87|||http://purl.uniprot.org/uniprot/F7DTY4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/13616:NCAM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAV9 ^@ Function ^@ This protein is a cell adhesion molecule involved in neuron-neuron adhesion, neurite fasciculation, outgrowth of neurites, etc. http://togogenome.org/gene/13616:CLCC1 ^@ http://purl.uniprot.org/uniprot/F7DG03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/13616:RUVBL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/13616:AAR2 ^@ http://purl.uniprot.org/uniprot/F7BCP7 ^@ Function|||Similarity ^@ Belongs to the AAR2 family.|||Component of the U5 snRNP complex that is required for spliceosome assembly and for pre-mRNA splicing. http://togogenome.org/gene/13616:LOC100026007 ^@ http://purl.uniprot.org/uniprot/F7D2Z8 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/13616:EXOC3L4 ^@ http://purl.uniprot.org/uniprot/F7CNI2 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/13616:CHRNE ^@ http://purl.uniprot.org/uniprot/A0A5F8HBH8|||http://purl.uniprot.org/uniprot/A0A5F8HCL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC107648921 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:KRT35 ^@ http://purl.uniprot.org/uniprot/F7ERN9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:RFLB ^@ http://purl.uniprot.org/uniprot/A0A5F8G4Z5|||http://purl.uniprot.org/uniprot/B1AAQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/13616:MRPS7 ^@ http://purl.uniprot.org/uniprot/F7FCF7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/13616:DNMT3L ^@ http://purl.uniprot.org/uniprot/A0A5F8HBK3|||http://purl.uniprot.org/uniprot/F6UJ13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100010920 ^@ http://purl.uniprot.org/uniprot/F7ESQ8 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/13616:SEPT9 ^@ http://purl.uniprot.org/uniprot/F6T758 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/13616:NEFM ^@ http://purl.uniprot.org/uniprot/F7BYP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||axon|||cytoskeleton http://togogenome.org/gene/13616:ESRP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESRP family.|||Nucleus http://togogenome.org/gene/13616:PABPN1 ^@ http://purl.uniprot.org/uniprot/F6U9B0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LMNA ^@ http://purl.uniprot.org/uniprot/F6V6C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/13616:DENND5B ^@ http://purl.uniprot.org/uniprot/F6W2Y5 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SERPINI2 ^@ http://purl.uniprot.org/uniprot/F7C1V8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:NPC1L1 ^@ http://purl.uniprot.org/uniprot/F7D6Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/13616:CTSH ^@ http://purl.uniprot.org/uniprot/F6RXJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:SMAD6 ^@ http://purl.uniprot.org/uniprot/F6RFA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MC4R ^@ http://purl.uniprot.org/uniprot/A8QXS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/13616:SEPSECS ^@ http://purl.uniprot.org/uniprot/F6VAK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm|||Homotetramer formed by a catalytic dimer and a non-catalytic dimer serving as a binding platform that orients tRNASec for catalysis. Each tetramer binds the CCA ends of two tRNAs which point to the active sites of the catalytic dimer. http://togogenome.org/gene/13616:KCNN2 ^@ http://purl.uniprot.org/uniprot/F7E0I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC103100524 ^@ http://purl.uniprot.org/uniprot/F7EED4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PLOD3 ^@ http://purl.uniprot.org/uniprot/F7ERJ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:CD38 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8N2|||http://purl.uniprot.org/uniprot/F6ZFL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADP-ribosyl cyclase family.|||Membrane http://togogenome.org/gene/13616:FREM2 ^@ http://purl.uniprot.org/uniprot/F6SBL8 ^@ Similarity ^@ Belongs to the FRAS1 family. http://togogenome.org/gene/13616:ATAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G386|||http://purl.uniprot.org/uniprot/A0A5F8HD97|||http://purl.uniprot.org/uniprot/A0A5F8HK89|||http://purl.uniprot.org/uniprot/F6R6N6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation strongly increases tubulin acetylation.|||Belongs to the acetyltransferase ATAT1 family.|||Component of the BBSome complex. Interacts with AP2 alpha-adaptins, including AP2A2, but not with AP1 gamma-adaptin (AP1G1/AP1G2); this interaction is required for efficient alpha-tubulin acetylation, hence clathrin-coated pits are sites of microtubule acetylation.|||Cytoplasm|||Specifically acetylates 'Lys-40' in alpha-tubulin on the lumenal side of microtubules. Promotes microtubule destabilization and accelerates microtubule dynamics; this activity may be independent of acetylation activity. Acetylates alpha-tubulin with a slow enzymatic rate, due to a catalytic site that is not optimized for acetyl transfer. Enters the microtubule through each end and diffuses quickly throughout the lumen of microtubules. Acetylates only long/old microtubules because of its slow acetylation rate since it does not have time to act on dynamically unstable microtubules before the enzyme is released. Required for normal sperm flagellar function. Promotes directional cell locomotion and chemotaxis, through AP2A2-dependent acetylation of alpha-tubulin at clathrin-coated pits that are concentrated at the leading edge of migrating cells. May facilitate primary cilium assembly.|||axon|||clathrin-coated pit|||cytoskeleton|||focal adhesion|||spindle http://togogenome.org/gene/13616:GJD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:TMEM131 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6F3 ^@ Similarity ^@ Belongs to the TMEM131 family. http://togogenome.org/gene/13616:ELAC1 ^@ http://purl.uniprot.org/uniprot/F7AQD1 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/13616:LOC103093835 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5M6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:AK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8W5|||http://purl.uniprot.org/uniprot/A0A5F8HBA4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/13616:LOC100019817 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6G9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:LOC100009955 ^@ http://purl.uniprot.org/uniprot/F6TAE7 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/13616:LOC100026277 ^@ http://purl.uniprot.org/uniprot/F6PG40 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/F7F4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Involved in the early steps of selenocysteine biosynthesis and tRNA(Sec) charging to the later steps resulting in the cotranslational incorporation of selenocysteine into selenoproteins. Stabilizes the SECISBP2, EEFSEC and tRNA(Sec) complex. May be involved in the methylation of tRNA(Sec). Enhances efficiency of selenoproteins synthesis.|||Nucleus http://togogenome.org/gene/13616:BCAP29 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQT6|||http://purl.uniprot.org/uniprot/F7A5H3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/13616:TAS1R3 ^@ http://purl.uniprot.org/uniprot/F7B3I8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ADGRF5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G938|||http://purl.uniprot.org/uniprot/F7DA49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/13616:ETFA ^@ http://purl.uniprot.org/uniprot/F7CUV6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/13616:SMC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:PBX2 ^@ http://purl.uniprot.org/uniprot/F6YKT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/13616:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/F7BQX3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:E2F6 ^@ http://purl.uniprot.org/uniprot/F7BB66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/13616:PLPPR5 ^@ http://purl.uniprot.org/uniprot/F7FYT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:RPA1 ^@ http://purl.uniprot.org/uniprot/F6YRP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/13616:PTAR1 ^@ http://purl.uniprot.org/uniprot/F7EJ46 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/13616:SLC1A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBT1|||http://purl.uniprot.org/uniprot/F7FKB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:SSU72 ^@ http://purl.uniprot.org/uniprot/F7GEV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/13616:SLC52A3 ^@ http://purl.uniprot.org/uniprot/F6Z2F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/13616:SNTA1 ^@ http://purl.uniprot.org/uniprot/F6PP33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/13616:VN2R539 ^@ http://purl.uniprot.org/uniprot/F6W427 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CHSY1 ^@ http://purl.uniprot.org/uniprot/F7ALM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:FZR1 ^@ http://purl.uniprot.org/uniprot/F6PS44 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/13616:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0U1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:PARD6G ^@ http://purl.uniprot.org/uniprot/A0A5F8H752|||http://purl.uniprot.org/uniprot/F7E002 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/13616:GEM ^@ http://purl.uniprot.org/uniprot/F7B0E6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/13616:TPMT ^@ http://purl.uniprot.org/uniprot/F6XB36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/13616:PTGR1 ^@ http://purl.uniprot.org/uniprot/F6U6I4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/13616:RPS11 ^@ http://purl.uniprot.org/uniprot/F7GIM6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/13616:CMPK2 ^@ http://purl.uniprot.org/uniprot/F7ASM8 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/13616:LASP1 ^@ http://purl.uniprot.org/uniprot/F6WDS9 ^@ Function|||Subcellular Location Annotation ^@ Plays an important role in the regulation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to regulate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types.|||cell cortex|||cytoskeleton http://togogenome.org/gene/13616:MCRIP2 ^@ http://purl.uniprot.org/uniprot/F7D1U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCRIP family.|||Nucleus|||Stress granule http://togogenome.org/gene/13616:C3H8orf82 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQL4 ^@ Similarity ^@ Belongs to the UPF0598 family. http://togogenome.org/gene/13616:STAG1 ^@ http://purl.uniprot.org/uniprot/F7GD67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/13616:GORASP1 ^@ http://purl.uniprot.org/uniprot/K7DZF6 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/13616:SLC5A12 ^@ http://purl.uniprot.org/uniprot/F7AKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:LOC100024622 ^@ http://purl.uniprot.org/uniprot/F7DEM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:AZIN1 ^@ http://purl.uniprot.org/uniprot/F6T425 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/13616:FGF19 ^@ http://purl.uniprot.org/uniprot/F6VVN7 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:INSIG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5H3|||http://purl.uniprot.org/uniprot/A0A5F8GA97|||http://purl.uniprot.org/uniprot/F6US40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/13616:DHRS4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSE2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:SFMBT2 ^@ http://purl.uniprot.org/uniprot/F7E6I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SATB2 ^@ http://purl.uniprot.org/uniprot/F7E1V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/13616:PPME1 ^@ http://purl.uniprot.org/uniprot/F7EE69 ^@ Function|||Similarity|||Subunit ^@ Belongs to the AB hydrolase superfamily.|||Binds PPP2CA and PPP2CB.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates PPP2CB (in vitro) and PPP2CA. Binding to PPP2CA displaces the manganese ion and inactivates the enzyme. http://togogenome.org/gene/13616:LOC100010349 ^@ http://purl.uniprot.org/uniprot/F7FWN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/13616:MOXD1 ^@ http://purl.uniprot.org/uniprot/F7E0X4 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/13616:MOG ^@ http://purl.uniprot.org/uniprot/F6ZHT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Homodimer.|||Membrane|||Minor component of the myelin sheath. May be involved in completion and/or maintenance of the myelin sheath and in cell-cell communication. Mediates homophilic cell-cell adhesion. http://togogenome.org/gene/13616:TMEM200A ^@ http://purl.uniprot.org/uniprot/A0A5F8GV59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/13616:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/F7BQD7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:IL12A ^@ http://purl.uniprot.org/uniprot/F6T5A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-6 superfamily.|||Heterodimer with IL12B; disulfide-linked. The heterodimer is known as interleukin IL-12.|||Heterodimerizes with IL12B to form the IL-12 cytokine or with EBI3/IL27B to form the IL-35 cytokine. IL-12 is primarily produced by professional antigen-presenting cells (APCs) such as B-cells and dendritic cells (DCs) as well as macrophages and granulocytes and regulates T-cell and natural killer-cell responses, induces the production of interferon-gamma (IFN-gamma), favors the differentiation of T-helper 1 (Th1) cells and is an important link between innate resistance and adaptive immunity. Mechanistically, exerts its biological effects through a receptor composed of IL12R1 and IL12R2 subunits. Binding to the receptor results in the rapid tyrosine phosphorylation of a number of cellular substrates including the JAK family kinases TYK2 and JAK2. In turn, recruited STAT4 gets phosphorylated and translocates to the nucleus where it regulates cytokine/growth factor responsive genes. As part of IL-35, plays essential roles in maintaining the immune homeostasis of the liver microenvironment and functions also as an immune-suppressive cytokine. Mediates biological events through unconventional receptors composed of IL12RB2 and gp130/IL6ST heterodimers or homodimers. Signaling requires the transcription factors STAT1 and STAT4, which form a unique heterodimer that binds to distinct DNA sites.|||Secreted http://togogenome.org/gene/13616:CAMK2A ^@ http://purl.uniprot.org/uniprot/F6QSC1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/13616:SCOC ^@ http://purl.uniprot.org/uniprot/F6V246 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/13616:GSS ^@ http://purl.uniprot.org/uniprot/F7G4W7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/13616:ST14 ^@ http://purl.uniprot.org/uniprot/F7ASK3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1 family.|||Degrades extracellular matrix.|||Interacts with CDCP1. May interact with TMEFF1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ARRDC3 ^@ http://purl.uniprot.org/uniprot/F6YRB9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/13616:PDGFA ^@ http://purl.uniprot.org/uniprot/A0A5F8GD53|||http://purl.uniprot.org/uniprot/A0A5F8GF15 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/13616:TNFSF11 ^@ http://purl.uniprot.org/uniprot/F7BYM9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/13616:F12 ^@ http://purl.uniprot.org/uniprot/F6UQB2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:STMN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBD4|||http://purl.uniprot.org/uniprot/F6ZRY0 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/13616:MCHR2 ^@ http://purl.uniprot.org/uniprot/F7FT78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FAM110C ^@ http://purl.uniprot.org/uniprot/F6Y1F9 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/13616:CCDC85C ^@ http://purl.uniprot.org/uniprot/A0A5F8H5G2|||http://purl.uniprot.org/uniprot/F6QKS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/13616:WNT9B ^@ http://purl.uniprot.org/uniprot/A0A5F8G2P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:CA5B ^@ http://purl.uniprot.org/uniprot/F6XEV7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:PSMF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5X4|||http://purl.uniprot.org/uniprot/F6UUG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/13616:LOC100018337 ^@ http://purl.uniprot.org/uniprot/F6UBZ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:AMACR ^@ http://purl.uniprot.org/uniprot/F7BZS2 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/13616:ATP11C ^@ http://purl.uniprot.org/uniprot/A0A5F8GM80|||http://purl.uniprot.org/uniprot/A0A5F8GY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:AZIN2 ^@ http://purl.uniprot.org/uniprot/F6VZY0 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/13616:KANSL2 ^@ http://purl.uniprot.org/uniprot/F6QBP6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.|||Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.|||Nucleus http://togogenome.org/gene/13616:BSG ^@ http://purl.uniprot.org/uniprot/F7E424 ^@ Subcellular Location Annotation ^@ Basolateral cell membrane|||Cell membrane|||Endoplasmic reticulum membrane|||Lateral cell membrane http://togogenome.org/gene/13616:INSL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted|||Seems to play a role in testicular function. May be a trophic hormone with a role in testicular descent in fetal life. Is a ligand for LGR8 receptor. http://togogenome.org/gene/13616:MCPH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGF8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Implicated in chromosome condensation and DNA damage induced cellular responses. May play a role in neurogenesis and regulation of the size of the cerebral cortex.|||Interacts with CDC27 and maybe other components of the APC/C complex. Interacts with histone variant H2AX under DNA damage conditions.|||centrosome http://togogenome.org/gene/13616:RAP2C ^@ http://purl.uniprot.org/uniprot/F6XZ48 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/13616:RNF8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGK1|||http://purl.uniprot.org/uniprot/A0A5F8GW89 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF8 initiate H2A 'Lys-63'-linked ubiquitination leading to recruitment of RNF168 to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Autoubiquitinated through 'Lys-48' and 'Lys-63' of ubiquitin. 'Lys-63' polyubiquitination is mediated by UBE2N. 'Lys-29'-type polyubiquitination is also observed, but it doesn't require its own functional RING-type zinc finger.|||Belongs to the CHFR family.|||Belongs to the RNF8 family.|||Cytoplasm|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). Also controls the recruitment of UIMC1-BRCC3 (RAP80-BRCC36) and PAXIP1/PTIP to DNA damage sites. Also recruited at DNA interstrand cross-links (ICLs) sites and catalyzes 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Promotes the formation of 'Lys-63'-linked polyubiquitin chains via interactions with the specific ubiquitin-conjugating UBE2N/UBC13 and ubiquitinates non-histone substrates such as PCNA. Substrates that are polyubiquitinated at 'Lys-63' are usually not targeted for degradation. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains via interaction with the ubiquitin-conjugating UBE2L6/UBCH8, leading to degradation of substrate proteins such as CHEK2, JMJD2A/KDM4A and KU80/XRCC5: it is still unclear how the preference toward 'Lys-48'- versus 'Lys-63'-linked ubiquitination is regulated but it could be due to RNF8 ability to interact with specific E2 specific ligases. For instance, interaction with phosphorylated HERC2 promotes the association between RNF8 and UBE2N/UBC13 and favors the specific formation of 'Lys-63'-linked ubiquitin chains. Promotes non-homologous end joining (NHEJ) by promoting the 'Lys-48'-linked ubiquitination and degradation the of KU80/XRCC5. Following DNA damage, mediates the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF168, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Following DNA damage, mediates the ubiquitination and degradation of POLD4/p12, a subunit of DNA polymerase delta. In the absence of POLD4, DNA polymerase delta complex exhibits higher proofreading activity. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation. Involved in the activation of ATM by promoting histone H2B ubiquitination, which indirectly triggers histone H4 'Lys-16' acetylation (H4K16ac), establishing a chromatin environment that promotes efficient activation of ATM kinase. Required in the testis, where it plays a role in the replacement of histones during spermatogenesis. At uncapped telomeres, promotes the joining of deprotected chromosome ends by inducing H2A ubiquitination and TP53BP1 recruitment, suggesting that it may enhance cancer development by aggravating telomere-induced genome instability in case of telomeric crisis. Promotes the assembly of RAD51 at DNA DSBs in the absence of BRCA1 and TP53BP1 Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. May be required for proper exit from mitosis after spindle checkpoint activation and may regulate cytokinesis. May play a role in the regulation of RXRA-mediated transcriptional activity. Not involved in RXRA ubiquitination by UBE2E2.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2. Interacts with class III E2s, including UBE2E1, UBE2E2, and UBE2E3 and with UBE2N. Interacts with RXRA. Interacts (via FHA domain) with phosphorylated HERC2 (via C-terminus). Interacts with PIWIL1; leading to sequester RNF8 in the cytoplasm.|||Midbody|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1 and phosphorylated HERC2.|||telomere http://togogenome.org/gene/13616:LOC100030436 ^@ http://purl.uniprot.org/uniprot/F7BRF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRIQK ^@ http://purl.uniprot.org/uniprot/F7BU50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:PTER ^@ http://purl.uniprot.org/uniprot/F6Y8J3 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ACE2 ^@ http://purl.uniprot.org/uniprot/F6WXR7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/13616:LOC100011118 ^@ http://purl.uniprot.org/uniprot/F6PXT9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/13616:LOC100014881 ^@ http://purl.uniprot.org/uniprot/F7C1X6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:TENM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJU6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ADI1 ^@ http://purl.uniprot.org/uniprot/F7FKV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway. Also down-regulates cell migration mediated by MMP14.|||Cell membrane|||Cytoplasm|||Monomer. Interacts with MMP14.|||Nucleus http://togogenome.org/gene/13616:CHRM2 ^@ http://purl.uniprot.org/uniprot/F7DJJ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/13616:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:LOC100012635 ^@ http://purl.uniprot.org/uniprot/F6WA61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Involved in actively transporting phosphate into cells via Na(+) cotransport.|||Membrane http://togogenome.org/gene/13616:RHBDD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PSAT1 ^@ http://purl.uniprot.org/uniprot/F7DC74 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/13616:ABCC2 ^@ http://purl.uniprot.org/uniprot/F6Z127 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PIAS4 ^@ http://purl.uniprot.org/uniprot/F6SSV5 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/13616:CRIPT ^@ http://purl.uniprot.org/uniprot/F7ESU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/13616:RPL14 ^@ http://purl.uniprot.org/uniprot/F6U375 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/13616:TMEM138 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAA5|||http://purl.uniprot.org/uniprot/A0A5F8HJB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM138 family.|||Membrane|||Required for ciliogenesis.|||Vacuole membrane|||cilium http://togogenome.org/gene/13616:RPS27A ^@ http://purl.uniprot.org/uniprot/F6T5K6 ^@ Function|||Similarity|||Subunit ^@ Component of the 40S subunit of the ribosome.|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Ribosomal protein S27a is part of the 40S ribosomal subunit. http://togogenome.org/gene/13616:SNX11 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/13616:MEA1 ^@ http://purl.uniprot.org/uniprot/F7CP91 ^@ Function ^@ May play an important role in spermatogenesis and/or testis development. http://togogenome.org/gene/13616:TFR2 ^@ http://purl.uniprot.org/uniprot/F6R440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SPTLC2 ^@ http://purl.uniprot.org/uniprot/F7E6T2 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/13616:GRIK4 ^@ http://purl.uniprot.org/uniprot/F7FB74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/13616:PLXNC1 ^@ http://purl.uniprot.org/uniprot/F7C5U5 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CTSZ ^@ http://purl.uniprot.org/uniprot/F6ZD89 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:RIBC2 ^@ http://purl.uniprot.org/uniprot/F7FQY6 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/13616:LECT1 ^@ http://purl.uniprot.org/uniprot/F6YNA3 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/13616:KCND2 ^@ http://purl.uniprot.org/uniprot/F7F5R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. D (Shal) (TC 1.A.1.2) subfamily. Kv4.2/KCND2 sub-subfamily.|||Cell junction|||Cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite|||dendritic spine http://togogenome.org/gene/13616:METTL6 ^@ http://purl.uniprot.org/uniprot/F7E9G8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/13616:monDomV1R1203 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMEM192 ^@ http://purl.uniprot.org/uniprot/F7CWE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:LOC100016492 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CRAT ^@ http://purl.uniprot.org/uniprot/A0A5F8H5F9|||http://purl.uniprot.org/uniprot/F7DGV8 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/13616:CLDN9 ^@ http://purl.uniprot.org/uniprot/F6ZDG4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:KEG11_p11 ^@ http://purl.uniprot.org/uniprot/Q65CJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9X6 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/13616:INIP ^@ http://purl.uniprot.org/uniprot/F6U5A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/13616:FBXO46 ^@ http://purl.uniprot.org/uniprot/K7E0C4 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/13616:STARD13 ^@ http://purl.uniprot.org/uniprot/F6YBE5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:SNW1 ^@ http://purl.uniprot.org/uniprot/F7GGY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNW family.|||Identified in the spliceosome C complex.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/13616:EGR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Nucleus|||Transcriptional regulator. Recognizes and binds to the DNA sequence 5'-GCG(T/G)GGGCG-3'(EGR-site) in the promoter region of target genes. Binds double-stranded target DNA, irrespective of the cytosine methylation status. Regulates the transcription of numerous target genes, and thereby plays an important role in regulating the response to growth factors, DNA damage, and ischemia. Plays a role in the regulation of cell survival, proliferation and cell death. http://togogenome.org/gene/13616:BOK ^@ http://purl.uniprot.org/uniprot/F7G9S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane http://togogenome.org/gene/13616:YPEL4 ^@ http://purl.uniprot.org/uniprot/F7ERY8 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/13616:NPTX2 ^@ http://purl.uniprot.org/uniprot/F7BVD5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPS16 ^@ http://purl.uniprot.org/uniprot/F7C3L8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/13616:LOC100025644 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG58 ^@ Similarity ^@ Belongs to the 2-5A synthase family. http://togogenome.org/gene/13616:SLC2A9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2I1|||http://purl.uniprot.org/uniprot/A0A5F8GSW3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/13616:CYP1A1 ^@ http://purl.uniprot.org/uniprot/F7DFG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:monDomV1R1245 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MFSD7 ^@ http://purl.uniprot.org/uniprot/F6XEJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MAP2K2 ^@ http://purl.uniprot.org/uniprot/F6S9S9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:ZUFSP ^@ http://purl.uniprot.org/uniprot/A0A5F8G7K3 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C78 family. ZUFSP subfamily.|||Interacts with RPA1 and RPA2. http://togogenome.org/gene/13616:SNTG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4F3|||http://purl.uniprot.org/uniprot/A0A5F8G9Z1|||http://purl.uniprot.org/uniprot/F6UUW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/13616:DYRK4 ^@ http://purl.uniprot.org/uniprot/F6PWQ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/13616:CNTF ^@ http://purl.uniprot.org/uniprot/A0A5F8HE74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNTF family.|||CNTF is a survival factor for various neuronal cell types. Seems to prevent the degeneration of motor axons after axotomy.|||Cytoplasm http://togogenome.org/gene/13616:SEBOX ^@ http://purl.uniprot.org/uniprot/A0A5F8HEM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100024173 ^@ http://purl.uniprot.org/uniprot/F7EI14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NIPSNAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTP3 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/13616:MFSD6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7J5|||http://purl.uniprot.org/uniprot/A0A5F8HC90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/13616:IL1RN ^@ http://purl.uniprot.org/uniprot/F6TEW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anti-inflammatory antagonist of interleukin-1 family of proinflammatory cytokines such as interleukin-1beta/IL1B and interleukin-1alpha/IL1A. Protects from immune dysregulation and uncontrolled systemic inflammation triggered by IL1 for a range of innate stimulatory agents such as pathogens.|||Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/13616:MAFB ^@ http://purl.uniprot.org/uniprot/A0A5F8G788|||http://purl.uniprot.org/uniprot/F6XN23 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/13616:OPRK1 ^@ http://purl.uniprot.org/uniprot/F7F9H9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with SLC9A3R1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/13616:VPS37A ^@ http://purl.uniprot.org/uniprot/F7AXY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/13616:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A5F8GYS8|||http://purl.uniprot.org/uniprot/F6SFT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/13616:LOC100020096 ^@ http://purl.uniprot.org/uniprot/F7BM51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Essential hepatic enzyme that catalyzes the oxygenation of a wide variety of nitrogen- and sulfur-containing compounds including drugs as well as dietary compounds. Plays an important role in the metabolism of trimethylamine (TMA), via the production of trimethylamine N-oxide (TMAO) metabolite. TMA is generated by the action of gut microbiota using dietary precursors such as choline, choline containing compounds, betaine or L-carnitine. By regulating TMAO concentration, FMO3 directly impacts both platelet responsiveness and rate of thrombus formation.|||Microsome membrane http://togogenome.org/gene/13616:LOC100618560 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100020786 ^@ http://purl.uniprot.org/uniprot/F6PZ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TSC22D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSA9|||http://purl.uniprot.org/uniprot/F6T2U7 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/13616:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/F6SXZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/13616:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJ88 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:IFI6 ^@ http://purl.uniprot.org/uniprot/F7CKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/13616:RFC1 ^@ http://purl.uniprot.org/uniprot/F7BBS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/13616:NDFIP2 ^@ http://purl.uniprot.org/uniprot/F6QMS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DUSP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/13616:NHSL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD61|||http://purl.uniprot.org/uniprot/A0A5F8GWA6|||http://purl.uniprot.org/uniprot/A0A5F8GWX4|||http://purl.uniprot.org/uniprot/F6PJQ8 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/13616:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G741 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100018393 ^@ http://purl.uniprot.org/uniprot/F6VEU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MODO-UB ^@ http://purl.uniprot.org/uniprot/Q5W5U6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:LOC100028068 ^@ http://purl.uniprot.org/uniprot/F7G826 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TFAP2D ^@ http://purl.uniprot.org/uniprot/F7GKB3 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/13616:LOC100031405 ^@ http://purl.uniprot.org/uniprot/F6YI65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Interacts with EIF4B, IMP8, PRMT5 and TNRC6B. Interacts with APOBEC3F, APOBEC3G and APOBEC3H.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/13616:MLST8 ^@ http://purl.uniprot.org/uniprot/F6ZQS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of the mammalian target of rapamycin complex 1 (mTORC1) which contains MTOR, MLST8, RPTOR, AKT1S1/PRAS40 and DEPTOR. mTORC1 binds to and is inhibited by FKBP12-rapamycin. Part of the mammalian target of rapamycin complex 2 (mTORC2) which contains MTOR, MLST8, PRR5, RICTOR, MAPKAP1 and DEPTOR. Contrary to mTORC1, mTORC2 does not bind to and is not sensitive to FKBP12-rapamycin. Interacts directly with MTOR and RPTOR. Interacts with RHEB. Interacts with MEAK7. Interacts with SIK3.|||Subunit of both mTORC1 and mTORC2, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1, which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, LST8 interacts directly with MTOR and enhances its kinase activity. In nutrient-poor conditions, stabilizes the MTOR-RPTOR interaction and favors RPTOR-mediated inhibition of MTOR activity. mTORC2 is also activated by growth factors, but seems to be nutrient-insensitive. mTORC2 seems to function upstream of Rho GTPases to regulate the actin cytoskeleton, probably by activating one or more Rho-type guanine nucleotide exchange factors. mTORC2 promotes the serum-induced formation of stress-fibers or F-actin. mTORC2 plays a critical role in AKT1 phosphorylation, which may facilitate the phosphorylation of the activation loop of AKT1 by PDK1 which is a prerequisite for full activation. mTORC2 regulates the phosphorylation of SGK1. mTORC2 also modulates the phosphorylation of PRKCA. http://togogenome.org/gene/13616:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/13616:PKLR ^@ http://purl.uniprot.org/uniprot/F6XZC6|||http://purl.uniprot.org/uniprot/K7E2Q6 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/13616:FMNL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTE0|||http://purl.uniprot.org/uniprot/F6UDT7 ^@ Similarity ^@ Belongs to the formin homology family. http://togogenome.org/gene/13616:MRPS6 ^@ http://purl.uniprot.org/uniprot/F6VJJ3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/13616:MMP9 ^@ http://purl.uniprot.org/uniprot/F6X875 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/13616:PGAM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU47|||http://purl.uniprot.org/uniprot/F6VBM7 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/13616:SLC25A44 ^@ http://purl.uniprot.org/uniprot/F6VN60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:BUD13 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCJ7|||http://purl.uniprot.org/uniprot/F6ZX29 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/13616:CA12 ^@ http://purl.uniprot.org/uniprot/A0A5F8G655|||http://purl.uniprot.org/uniprot/A0A5F8GDB5|||http://purl.uniprot.org/uniprot/F7F4C7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:GABARAP ^@ http://purl.uniprot.org/uniprot/A0A5F8GH28 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/13616:SLC6A13 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDU4 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CDH6 ^@ http://purl.uniprot.org/uniprot/F6Y191 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1260 ^@ http://purl.uniprot.org/uniprot/F6V7F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2S5|||http://purl.uniprot.org/uniprot/A0A5F8GC18|||http://purl.uniprot.org/uniprot/F6W7Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/13616:CLDN18 ^@ http://purl.uniprot.org/uniprot/F7GCU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:ITGA8 ^@ http://purl.uniprot.org/uniprot/F6TCV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:KPNA1 ^@ http://purl.uniprot.org/uniprot/F6PVH5 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:ADGB ^@ http://purl.uniprot.org/uniprot/A0A5F8G1N3|||http://purl.uniprot.org/uniprot/A0A5F8G9G5|||http://purl.uniprot.org/uniprot/F6RUJ9 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PCNX2 ^@ http://purl.uniprot.org/uniprot/F7CC88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/13616:FAM69A ^@ http://purl.uniprot.org/uniprot/F6U180 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:PSME1 ^@ http://purl.uniprot.org/uniprot/F7GBS5 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/13616:GSK3B ^@ http://purl.uniprot.org/uniprot/A0A5F8GBH0|||http://purl.uniprot.org/uniprot/A0A5F8HIG1|||http://purl.uniprot.org/uniprot/F6PGQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MYO1B ^@ http://purl.uniprot.org/uniprot/A0A5F8G3G8|||http://purl.uniprot.org/uniprot/A0A5F8GY12|||http://purl.uniprot.org/uniprot/A0A5F8HAT0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:VN2R556 ^@ http://purl.uniprot.org/uniprot/F6T901 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1283 ^@ http://purl.uniprot.org/uniprot/F7GES5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SSBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSL6 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/13616:POLR3C ^@ http://purl.uniprot.org/uniprot/F7EF59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC3/POLR3C RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/13616:LOC100013294 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:KIAA1024 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTD6|||http://purl.uniprot.org/uniprot/A0A5F8H4P0 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/13616:TSHZ3 ^@ http://purl.uniprot.org/uniprot/F6PNB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the teashirt C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:ST8SIA1 ^@ http://purl.uniprot.org/uniprot/F7ELG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:TMEM38A ^@ http://purl.uniprot.org/uniprot/F7FI88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/13616:NFIL3 ^@ http://purl.uniprot.org/uniprot/F6VLC7 ^@ Similarity ^@ Belongs to the bZIP family. NFIL3 subfamily. http://togogenome.org/gene/13616:CENPO ^@ http://purl.uniprot.org/uniprot/F7AGM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/13616:ADCY3 ^@ http://purl.uniprot.org/uniprot/F7B3B0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/13616:FAP ^@ http://purl.uniprot.org/uniprot/F7DK16 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/13616:GNA12 ^@ http://purl.uniprot.org/uniprot/F6TFQ0|||http://purl.uniprot.org/uniprot/K7E5E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/13616:TMEM107 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100024194 ^@ http://purl.uniprot.org/uniprot/F7A1K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:AKR1B1 ^@ http://purl.uniprot.org/uniprot/K7E1G6 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/13616:SLC9A9 ^@ http://purl.uniprot.org/uniprot/F6TJF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:ZFX ^@ http://purl.uniprot.org/uniprot/F7GJX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ANKH ^@ http://purl.uniprot.org/uniprot/F6Q5B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKH family.|||Membrane|||Regulates intra- and extracellular levels of inorganic pyrophosphate (PPi), probably functioning as PPi transporter. http://togogenome.org/gene/13616:PLXNB3 ^@ http://purl.uniprot.org/uniprot/F6PJL2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100012041 ^@ http://purl.uniprot.org/uniprot/F6SSZ9 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/13616:LOC100018508 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB60|||http://purl.uniprot.org/uniprot/F7GHL5 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/13616:DPCD ^@ http://purl.uniprot.org/uniprot/F7DFJ0 ^@ Similarity ^@ Belongs to the DPCD family. http://togogenome.org/gene/13616:ART5 ^@ http://purl.uniprot.org/uniprot/F7A3I9 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/13616:DCTN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV11|||http://purl.uniprot.org/uniprot/F7EQF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/13616:DLAT ^@ http://purl.uniprot.org/uniprot/A0A5F8G712 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 2 lipoyl cofactors covalently.|||Mitochondrion matrix|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/13616:FAM160B2 ^@ http://purl.uniprot.org/uniprot/F6QTD9|||http://purl.uniprot.org/uniprot/F7DSY2 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/13616:GRHPR ^@ http://purl.uniprot.org/uniprot/A0A5F8GK27 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/13616:SLC22A1 ^@ http://purl.uniprot.org/uniprot/F6PRJ7 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/13616:KLRK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKU4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AGPAT2 ^@ http://purl.uniprot.org/uniprot/F7AHW4 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/13616:HS2ST1 ^@ http://purl.uniprot.org/uniprot/F7ELC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/13616:MED14 ^@ http://purl.uniprot.org/uniprot/F6UIC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/13616:YOD1 ^@ http://purl.uniprot.org/uniprot/F6YEW2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and participates in endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by triming the ubiquitin chain on the associated substrate to facilitate their threading through the VCP/p97 pore. Cleaves both polyubiquitin and di-ubiquitin. http://togogenome.org/gene/13616:MFAP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTC1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100618720 ^@ http://purl.uniprot.org/uniprot/F6Q2K6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100032873 ^@ http://purl.uniprot.org/uniprot/F7EXL4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. Plunc family.|||Monomer. Interacts (via N-terminus) with SCNN1B, a subunit of the heterotrimeric epithelial sodium channel (ENaC); this inhibits proteolytic activation of ENaC.|||Secreted http://togogenome.org/gene/13616:LOC100031219 ^@ http://purl.uniprot.org/uniprot/F6RSG9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:ACTR3B ^@ http://purl.uniprot.org/uniprot/F6TPU3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:PPIL3 ^@ http://purl.uniprot.org/uniprot/F7BX89 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:TNFRSF11A ^@ http://purl.uniprot.org/uniprot/F7AS58 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RRAGD ^@ http://purl.uniprot.org/uniprot/F6Q6M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/13616:LOC100020624 ^@ http://purl.uniprot.org/uniprot/F7API2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAA7|||http://purl.uniprot.org/uniprot/A0A5F8GDX2|||http://purl.uniprot.org/uniprot/A0A5F8GLJ5|||http://purl.uniprot.org/uniprot/F7DKR4 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/13616:LOC100020685 ^@ http://purl.uniprot.org/uniprot/F7A114 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PEX7 ^@ http://purl.uniprot.org/uniprot/F6ZV69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Cytoplasm http://togogenome.org/gene/13616:THBS1 ^@ http://purl.uniprot.org/uniprot/F6WMA0 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/F6ZHW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/13616:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8J1|||http://purl.uniprot.org/uniprot/A0A5F8HET8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/13616:KIAA1715 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9H1|||http://purl.uniprot.org/uniprot/K7E0B9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Homodimer; homodimerization requires the C4-type zinc finger motif and decreases during mitosis in a phosphorylation-dependent manner.|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/13616:SLC2A2 ^@ http://purl.uniprot.org/uniprot/F6ZHU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:STK4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/13616:PDCD5 ^@ http://purl.uniprot.org/uniprot/F7E2R5 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/13616:LOC100019992 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAC6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/13616:B9D1 ^@ http://purl.uniprot.org/uniprot/K7E5P2 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/13616:SRPX2 ^@ http://purl.uniprot.org/uniprot/F7GLN8 ^@ Caution|||Subcellular Location Annotation ^@ Cell surface|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Synapse http://togogenome.org/gene/13616:DPAGT1 ^@ http://purl.uniprot.org/uniprot/F7A9Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC103094764 ^@ http://purl.uniprot.org/uniprot/F6SFK7 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/13616:LOC100011915 ^@ http://purl.uniprot.org/uniprot/F6ZBI1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC100012174 ^@ http://purl.uniprot.org/uniprot/F7CHH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:JAG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH40|||http://purl.uniprot.org/uniprot/F7D3A1 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/13616:ENPP1 ^@ http://purl.uniprot.org/uniprot/F7BSJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Secreted http://togogenome.org/gene/13616:LOC100011600 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100028192 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CPNE9 ^@ http://purl.uniprot.org/uniprot/F7EIB0 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/13616:POLR3B ^@ http://purl.uniprot.org/uniprot/F6WGH7 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/13616:OPRL1 ^@ http://purl.uniprot.org/uniprot/F6XHC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/13616:LOC100027021 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5J0|||http://purl.uniprot.org/uniprot/F7AFX2 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/13616:LOC100619212 ^@ http://purl.uniprot.org/uniprot/F6ZIN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DLX2 ^@ http://purl.uniprot.org/uniprot/F7B4F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/13616:MED20 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:RC3H1 ^@ http://purl.uniprot.org/uniprot/F6SY20 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/13616:TGFB2 ^@ http://purl.uniprot.org/uniprot/F6XNK0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/13616:LOC100021845 ^@ http://purl.uniprot.org/uniprot/F7BRH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CACNG4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the activity of L-type calcium channels that contain CACNA1C as pore-forming subunit (By similarity). Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs), including GRIA1 and GRIA4. Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization and by mediating their resensitization. http://togogenome.org/gene/13616:VN2R606 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGY7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SUDS3 ^@ http://purl.uniprot.org/uniprot/F6XZ37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UBL4A ^@ http://purl.uniprot.org/uniprot/F7BQ80 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/13616:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/F6ZXK1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:HABP2 ^@ http://purl.uniprot.org/uniprot/F6XM86 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:SARDH ^@ http://purl.uniprot.org/uniprot/F7GBN5 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/13616:LOC100022736 ^@ http://purl.uniprot.org/uniprot/F7CAH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ITGA2 ^@ http://purl.uniprot.org/uniprot/F6RXC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:LOC103093665 ^@ http://purl.uniprot.org/uniprot/F7BK46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:DAD1 ^@ http://purl.uniprot.org/uniprot/F7CZ61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/13616:GFOD1 ^@ http://purl.uniprot.org/uniprot/F7DP86 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/13616:MAPK13 ^@ http://purl.uniprot.org/uniprot/F6TXC2 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/13616:LOC100619854 ^@ http://purl.uniprot.org/uniprot/F6SNL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MIS12 ^@ http://purl.uniprot.org/uniprot/F7GGZ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mis12 family.|||Component of the MIS12 complex composed of MIS12, DSN1, NSL1 and PMF1. Also interacts with KNL1, CBX3, CBX5, NDC80 and ZWINT.|||kinetochore http://togogenome.org/gene/13616:DENND5A ^@ http://purl.uniprot.org/uniprot/A0A5F8G9V0|||http://purl.uniprot.org/uniprot/F7A8J4 ^@ Caution|||Similarity ^@ Belongs to the RAB6IP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:DCLRE1B ^@ http://purl.uniprot.org/uniprot/F6X212 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/13616:CDS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/13616:DCPS ^@ http://purl.uniprot.org/uniprot/F6Y3D8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HIT family.|||Cytoplasm|||Decapping scavenger enzyme that catalyzes the cleavage of a residual cap structure following the degradation of mRNAs by the 3'->5' exosome-mediated mRNA decay pathway.|||Homodimer. Associates with components of the exosome multienzyme ribonuclease complex, such as EXOSC3 and EXOSC4. Interacts with NDOR1.|||Nucleus http://togogenome.org/gene/13616:C4BPB ^@ http://purl.uniprot.org/uniprot/F7G3E0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:THNSL1 ^@ http://purl.uniprot.org/uniprot/F6WJR7 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/13616:CDH11 ^@ http://purl.uniprot.org/uniprot/F6XVG8 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADGRF2 ^@ http://purl.uniprot.org/uniprot/F7DVG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:STON2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H276|||http://purl.uniprot.org/uniprot/F7EW99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/13616:PPIA ^@ http://purl.uniprot.org/uniprot/F7FZ45 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:INPP5K ^@ http://purl.uniprot.org/uniprot/A0A5F8HKR9 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/13616:LOC100013132 ^@ http://purl.uniprot.org/uniprot/F6Z964 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/13616:FH ^@ http://purl.uniprot.org/uniprot/F6XCG4 ^@ Function|||Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Catalyzes the hydration of fumarate to L-malate in the tricarboxylic acid (TCA) cycle to facilitate a transition step in the production of energy in the form of NADH. http://togogenome.org/gene/13616:LRWD1 ^@ http://purl.uniprot.org/uniprot/F6VF30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/13616:ROR2 ^@ http://purl.uniprot.org/uniprot/F6RDI3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:METTL10 ^@ http://purl.uniprot.org/uniprot/F6SAW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||Nucleus|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-318'. http://togogenome.org/gene/13616:SERPINE1 ^@ http://purl.uniprot.org/uniprot/F7C1N5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:LOC100023529 ^@ http://purl.uniprot.org/uniprot/F7F434 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC103106484 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Membrane|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. http://togogenome.org/gene/13616:DIMT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H757 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/13616:AP3M2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G829 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/13616:MME ^@ http://purl.uniprot.org/uniprot/F7FEB8 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:TRH ^@ http://purl.uniprot.org/uniprot/K7E2N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRH family.|||Functions as a regulator of the biosynthesis of TSH in the anterior pituitary gland and as a neurotransmitter/ neuromodulator in the central and peripheral nervous systems.|||Secreted http://togogenome.org/gene/13616:LOC100017854 ^@ http://purl.uniprot.org/uniprot/F6YZV6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:GLI2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAN0|||http://purl.uniprot.org/uniprot/F6RAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:USP22 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEI4|||http://purl.uniprot.org/uniprot/F7BCG1 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:TINAGL1 ^@ http://purl.uniprot.org/uniprot/K7E479 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:KCNE3 ^@ http://purl.uniprot.org/uniprot/F6WTC2 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/13616:TMEM35 ^@ http://purl.uniprot.org/uniprot/F7DFA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane|||Vesicle http://togogenome.org/gene/13616:PARP2 ^@ http://purl.uniprot.org/uniprot/F6RCB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/13616:COQ4 ^@ http://purl.uniprot.org/uniprot/F6WFU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FAM174B ^@ http://purl.uniprot.org/uniprot/F6ZLM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/13616:TRIM9 ^@ http://purl.uniprot.org/uniprot/F7C2Z3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:EIF1AX ^@ http://purl.uniprot.org/uniprot/K7E1Z1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/13616:TRUB2 ^@ http://purl.uniprot.org/uniprot/F6WW62 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/13616:IRF2 ^@ http://purl.uniprot.org/uniprot/F6SVQ4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:NADK ^@ http://purl.uniprot.org/uniprot/A0A5F8GV69 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/13616:LOC100017995 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE62 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/13616:ICAM2 ^@ http://purl.uniprot.org/uniprot/F7G0C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/13616:GPR155 ^@ http://purl.uniprot.org/uniprot/F7G012 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:monDomV1R1219 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8C5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:USP37 ^@ http://purl.uniprot.org/uniprot/F6SMT5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:KLHL40 ^@ http://purl.uniprot.org/uniprot/F7AVX2 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/13616:LOC100020188 ^@ http://purl.uniprot.org/uniprot/F7ED75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:MB21D1 ^@ http://purl.uniprot.org/uniprot/F7GD20 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/13616:DYRK1A ^@ http://purl.uniprot.org/uniprot/A0A5F8G6H1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/13616:LOC100024870 ^@ http://purl.uniprot.org/uniprot/F6VY06 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MTURN ^@ http://purl.uniprot.org/uniprot/F6T6L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTURN family.|||Cytoplasm http://togogenome.org/gene/13616:PBX4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/13616:CREB3L2 ^@ http://purl.uniprot.org/uniprot/F6W973 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. ATF subfamily.|||Binds DNA as a dimer.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:LOC103099606 ^@ http://purl.uniprot.org/uniprot/F7F990 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:EIF2D ^@ http://purl.uniprot.org/uniprot/F6UZY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/13616:LOC100020762 ^@ http://purl.uniprot.org/uniprot/F7EM99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PPT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWX6|||http://purl.uniprot.org/uniprot/F7G659 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the palmitoyl-protein thioesterase family.|||Lysosome http://togogenome.org/gene/13616:LOC100027961 ^@ http://purl.uniprot.org/uniprot/F6PSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC107651035 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DPH3 ^@ http://purl.uniprot.org/uniprot/F6RJE2 ^@ Similarity ^@ Belongs to the DPH3 family. http://togogenome.org/gene/13616:EPB41L5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAY6|||http://purl.uniprot.org/uniprot/K7E3J9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Photoreceptor inner segment|||Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. http://togogenome.org/gene/13616:PLCG1 ^@ http://purl.uniprot.org/uniprot/F6TAH0 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/13616:COPS2 ^@ http://purl.uniprot.org/uniprot/F7DDQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBK9|||http://purl.uniprot.org/uniprot/A0A5F8HCL1 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:BHMT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3W4 ^@ Cofactor|||Function|||Subunit ^@ Binds 1 zinc ion per subunit.|||Homotetramer.|||Involved in the regulation of homocysteine metabolism. http://togogenome.org/gene/13616:SNX1 ^@ http://purl.uniprot.org/uniprot/F7FIU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium|||trans-Golgi network membrane http://togogenome.org/gene/13616:BTG4 ^@ http://purl.uniprot.org/uniprot/F7FKK2 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/13616:SKA1 ^@ http://purl.uniprot.org/uniprot/F6ZJ97 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/13616:DSC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL62 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/13616:MALL ^@ http://purl.uniprot.org/uniprot/F6WSL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PLAC8 ^@ http://purl.uniprot.org/uniprot/F6RYA5 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/13616:VN2R640 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXZ2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100016683 ^@ http://purl.uniprot.org/uniprot/F6WJL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NOTCH2 ^@ http://purl.uniprot.org/uniprot/F7AVD5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/13616:FGA ^@ http://purl.uniprot.org/uniprot/F7CJ60 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/13616:AMER3 ^@ http://purl.uniprot.org/uniprot/F7B2Z7 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/13616:HSFX ^@ http://purl.uniprot.org/uniprot/A0A5F8G686|||http://purl.uniprot.org/uniprot/A0A5F8G6Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/13616:MBOAT1 ^@ http://purl.uniprot.org/uniprot/F6WIK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PCBD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNM8 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/13616:RNF152 ^@ http://purl.uniprot.org/uniprot/F7BN35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:SUSD5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEV7|||http://purl.uniprot.org/uniprot/F6QZI7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100015172 ^@ http://purl.uniprot.org/uniprot/F6VI36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/13616:LOC100031248 ^@ http://purl.uniprot.org/uniprot/F7EI61 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:TTC4 ^@ http://purl.uniprot.org/uniprot/F7D8P9 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/13616:POLR1B ^@ http://purl.uniprot.org/uniprot/F7B818 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/13616:PAX9 ^@ http://purl.uniprot.org/uniprot/F6VG93 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with KDM5B.|||Nucleus|||Transcription factor required for normal development of thymus, parathyroid glands, ultimobranchial bodies, teeth, skeletal elements of skull and larynx as well as distal limbs. http://togogenome.org/gene/13616:NTMT1 ^@ http://purl.uniprot.org/uniprot/F7CCN4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/13616:MAN2A2 ^@ http://purl.uniprot.org/uniprot/F6RWB3 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:GPR65 ^@ http://purl.uniprot.org/uniprot/F6YMU4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:SLC35A1 ^@ http://purl.uniprot.org/uniprot/F6PUN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/13616:FAH ^@ http://purl.uniprot.org/uniprot/A0A5F8GBC8 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/13616:RENBP ^@ http://purl.uniprot.org/uniprot/F6QCF6 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/13616:WARS ^@ http://purl.uniprot.org/uniprot/F7ACJ5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:NASP ^@ http://purl.uniprot.org/uniprot/F7CC16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/13616:MED6 ^@ http://purl.uniprot.org/uniprot/F6RC94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/13616:FUT7 ^@ http://purl.uniprot.org/uniprot/F6T3M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/13616:LOC103102395 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/13616:DNAH7 ^@ http://purl.uniprot.org/uniprot/F7FU84 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/13616:LOC100017655 ^@ http://purl.uniprot.org/uniprot/F6U3G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/13616:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/F7EBM0 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/13616:NDUFA2 ^@ http://purl.uniprot.org/uniprot/F6W1H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100029158 ^@ http://purl.uniprot.org/uniprot/F7EH45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:EEF2K ^@ http://purl.uniprot.org/uniprot/A0A5F8GW10|||http://purl.uniprot.org/uniprot/F7C485 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Alpha-type protein kinase family.|||Monomer or homodimer.|||Undergoes calcium/calmodulin-dependent intramolecular autophosphorylation, and this results in it becoming partially calcium/calmodulin-independent. http://togogenome.org/gene/13616:QPRT ^@ http://purl.uniprot.org/uniprot/F7AQ58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/13616:MAP2K1 ^@ http://purl.uniprot.org/uniprot/F6XT65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:YRDC ^@ http://purl.uniprot.org/uniprot/F7E541 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/13616:LGI2 ^@ http://purl.uniprot.org/uniprot/F6US32 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:RAP1GDS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5W2|||http://purl.uniprot.org/uniprot/F7BAB1 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Mitochondrion|||cytosol http://togogenome.org/gene/13616:LOC103105104 ^@ http://purl.uniprot.org/uniprot/F6RJI9 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/13616:LOC100031136 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3A3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJA1|||http://purl.uniprot.org/uniprot/F7CDZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/13616:HSPA13 ^@ http://purl.uniprot.org/uniprot/F6SPB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Binds UBQLN2.|||Endoplasmic reticulum|||Has peptide-independent ATPase activity.|||Microsome http://togogenome.org/gene/13616:LOC100020170 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R591 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRN0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:FAM150B ^@ http://purl.uniprot.org/uniprot/F6XIV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/13616:MAP2K5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G226|||http://purl.uniprot.org/uniprot/A0A5F8H919|||http://purl.uniprot.org/uniprot/F7C4E9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:SLC44A1 ^@ http://purl.uniprot.org/uniprot/F7BGP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/13616:SUFU ^@ http://purl.uniprot.org/uniprot/F6RMT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Negative regulator in the hedgehog signaling pathway. Down-regulates GLI1-mediated transactivation of target genes. Part of a corepressor complex that acts on DNA-bound GLI1. May also act by linking GLI1 to BTRC and thereby targeting GLI1 to degradation by the proteasome. Sequesters GLI1, GLI2 and GLI3 in the cytoplasm, this effect is overcome by binding of STK36 to both SUFU and a GLI protein. Negative regulator of beta-catenin signaling. Regulates the formation of either the repressor form (GLI3R) or the activator form (GLI3A) of the full-length form of GLI3 (GLI3FL). GLI3FL is complexed with SUFU in the cytoplasm and is maintained in a neutral state. Without the Hh signal, the SUFU-GLI3 complex is recruited to cilia, leading to the efficient processing of GLI3FL into GLI3R. When Hh signaling is initiated, SUFU dissociates from GLI3FL and the latter translocates to the nucleus, where it is phosphorylated, destabilized, and converted to a transcriptional activator (GLI3A).|||Nucleus http://togogenome.org/gene/13616:SPATS2 ^@ http://purl.uniprot.org/uniprot/F6XQE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATS2 family.|||Cytoplasm http://togogenome.org/gene/13616:PPP4R2 ^@ http://purl.uniprot.org/uniprot/F7G9R3 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/13616:MMP17 ^@ http://purl.uniprot.org/uniprot/F7AIM3 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A5F8GT51|||http://purl.uniprot.org/uniprot/F6XMR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/13616:SIVA1 ^@ http://purl.uniprot.org/uniprot/F6TX86 ^@ Function|||PTM|||Subcellular Location Annotation ^@ Cytoplasm|||Induces CD27-mediated apoptosis. Inhibits BCL2L1 isoform Bcl-x(L) anti-apoptotic activity. Inhibits activation of NF-kappa-B and promotes T-cell receptor-mediated apoptosis.|||Nucleus|||Phosphorylated by ABL2/ARG in response to oxidative stress. http://togogenome.org/gene/13616:LOC100617936 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:ALAS2 ^@ http://purl.uniprot.org/uniprot/F7G8E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:DYNC1LI1 ^@ http://purl.uniprot.org/uniprot/F6V4K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in binding dynein to membranous organelles or chromosomes.|||Belongs to the dynein light intermediate chain family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs).|||cytoskeleton http://togogenome.org/gene/13616:SH3BP5 ^@ http://purl.uniprot.org/uniprot/F7ER25 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/13616:SOX8 ^@ http://purl.uniprot.org/uniprot/F6XIA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ST7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIW5|||http://purl.uniprot.org/uniprot/A0A5F8GL78|||http://purl.uniprot.org/uniprot/F7FRY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/13616:STK35L3 ^@ http://purl.uniprot.org/uniprot/F6PGF5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100021916 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TUBE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Z7|||http://purl.uniprot.org/uniprot/F7GFL8 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/13616:MCM9 ^@ http://purl.uniprot.org/uniprot/F7CZV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:NRP1 ^@ http://purl.uniprot.org/uniprot/F7DVT3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:AGXT2 ^@ http://purl.uniprot.org/uniprot/F7F6D0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/13616:FIGNL1 ^@ http://purl.uniprot.org/uniprot/F6U499 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/13616:LOC100016733 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK04 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:RPGRIP1L ^@ http://purl.uniprot.org/uniprot/A0A5F8H3D1 ^@ Similarity ^@ Belongs to the RPGRIP1 family. http://togogenome.org/gene/13616:NMU ^@ http://purl.uniprot.org/uniprot/F6V218 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NmU family.|||Secreted http://togogenome.org/gene/13616:IZUMO1R ^@ http://purl.uniprot.org/uniprot/F7AHC3 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/13616:DLC1 ^@ http://purl.uniprot.org/uniprot/F7FZ87|||http://purl.uniprot.org/uniprot/F7FZ90 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.|||Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.|||Membrane|||focal adhesion http://togogenome.org/gene/13616:LOC100013123 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TIE1 ^@ http://purl.uniprot.org/uniprot/F6SPK9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MOGAT1 ^@ http://purl.uniprot.org/uniprot/F6XVS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:EFHC1 ^@ http://purl.uniprot.org/uniprot/F6YYR9 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/13616:USP44 ^@ http://purl.uniprot.org/uniprot/F7ELW8 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:LOC100018685 ^@ http://purl.uniprot.org/uniprot/F6QC34 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/13616:GRM4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR20|||http://purl.uniprot.org/uniprot/F6R6X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MVD ^@ http://purl.uniprot.org/uniprot/F6Y9W8 ^@ Function|||Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Catalyzes the ATP dependent decarboxylation of (R)-5-diphosphomevalonate to form isopentenyl diphosphate (IPP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoids and sterol synthesis. http://togogenome.org/gene/13616:GPC2 ^@ http://purl.uniprot.org/uniprot/F6SV42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/13616:LOC100030117 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9C1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/13616:AGPAT3 ^@ http://purl.uniprot.org/uniprot/F6W0F9 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:USP15 ^@ http://purl.uniprot.org/uniprot/F6WKA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/13616:BBS10 ^@ http://purl.uniprot.org/uniprot/F7FJJ6 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/13616:CWF19L1 ^@ http://purl.uniprot.org/uniprot/F6YQP7 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/13616:HSD17B1 ^@ http://purl.uniprot.org/uniprot/F7G656 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Favors the reduction of estrogens and androgens. Uses preferentially NADH. http://togogenome.org/gene/13616:LOC100023565 ^@ http://purl.uniprot.org/uniprot/F7EC75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/13616:PRKAA1 ^@ http://purl.uniprot.org/uniprot/F7BFG2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/13616:VN2R652 ^@ http://purl.uniprot.org/uniprot/A0A5F8G297 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:STX4 ^@ http://purl.uniprot.org/uniprot/F6WIC9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/13616:LIMK1 ^@ http://purl.uniprot.org/uniprot/F6X673 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/13616:LOC100016791 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NSUN3 ^@ http://purl.uniprot.org/uniprot/F6U5C4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/13616:MCTP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL23|||http://purl.uniprot.org/uniprot/A0A5F8H5K8|||http://purl.uniprot.org/uniprot/A0A5F8H8W6|||http://purl.uniprot.org/uniprot/F7DQX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SS18L1 ^@ http://purl.uniprot.org/uniprot/F7DLT2 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/13616:LOC100026632 ^@ http://purl.uniprot.org/uniprot/F7AJ77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:OPA3 ^@ http://purl.uniprot.org/uniprot/F7DZP8 ^@ Function|||Similarity ^@ Belongs to the OPA3 family.|||May play some role in mitochondrial processes. http://togogenome.org/gene/13616:CADM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7W2|||http://purl.uniprot.org/uniprot/A0A5F8GK08|||http://purl.uniprot.org/uniprot/A0A5F8HCB9|||http://purl.uniprot.org/uniprot/A0A5F8HE77|||http://purl.uniprot.org/uniprot/A0A5F8HFD4|||http://purl.uniprot.org/uniprot/F6W9D2 ^@ Similarity ^@ Belongs to the nectin family. http://togogenome.org/gene/13616:TAT ^@ http://purl.uniprot.org/uniprot/F7CW54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/13616:SF3B4 ^@ http://purl.uniprot.org/uniprot/F7DXP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/13616:NPC1 ^@ http://purl.uniprot.org/uniprot/F7G2R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/13616:ENTPD5 ^@ http://purl.uniprot.org/uniprot/F7BUY1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:DTD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMX9 ^@ Similarity ^@ Belongs to the DTD family. http://togogenome.org/gene/13616:TM6SF2 ^@ http://purl.uniprot.org/uniprot/F6WPM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:VPS18 ^@ http://purl.uniprot.org/uniprot/F6TFE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/13616:C5H4orf47 ^@ http://purl.uniprot.org/uniprot/F6XIF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0602 family.|||centrosome http://togogenome.org/gene/13616:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKM5|||http://purl.uniprot.org/uniprot/F7F5A9 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/13616:LRRC16A ^@ http://purl.uniprot.org/uniprot/F7G2M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/13616:UTS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/13616:ERLEC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGF0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/13616:LOC100618274 ^@ http://purl.uniprot.org/uniprot/F6PJW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DMRT1 ^@ http://purl.uniprot.org/uniprot/F6Z0D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/13616:PGLYRP1 ^@ http://purl.uniprot.org/uniprot/F7FSD2 ^@ Function|||Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family.|||Innate immunity protein that plays several important functions in antimicrobial and antitumor defense systems. http://togogenome.org/gene/13616:ZNF532 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2D2|||http://purl.uniprot.org/uniprot/F7AR81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/13616:T2R3A ^@ http://purl.uniprot.org/uniprot/Q2ABA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:SYNJ1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRI3 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/13616:TGIF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEI0|||http://purl.uniprot.org/uniprot/A0A5F8HCK7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:monDomV1R1234 ^@ http://purl.uniprot.org/uniprot/F7EX64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LECT2 ^@ http://purl.uniprot.org/uniprot/F7BWL0 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/13616:CD3E ^@ http://purl.uniprot.org/uniprot/F7D784 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MTMR2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3Y0|||http://purl.uniprot.org/uniprot/A0A5F8HDZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100029940 ^@ http://purl.uniprot.org/uniprot/F7FSK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:BEST4 ^@ http://purl.uniprot.org/uniprot/F7GF92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms calcium-sensitive chloride channels. Permeable to bicarbonate.|||Membrane http://togogenome.org/gene/13616:GTF2E2 ^@ http://purl.uniprot.org/uniprot/F7CP70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/13616:DPEP1 ^@ http://purl.uniprot.org/uniprot/F7GBL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Cell membrane|||Homodimer; disulfide-linked.|||Independently of its dipeptidase activity, acts as an adhesion receptor for neutrophil recruitment from bloodstream into inflamed lungs and liver.|||Membrane http://togogenome.org/gene/13616:DOLPP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GI55|||http://purl.uniprot.org/uniprot/F7FFJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/13616:MAP3K11 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7F6|||http://purl.uniprot.org/uniprot/F6QT87 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/13616:FOXB2 ^@ http://purl.uniprot.org/uniprot/F7DZ45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100030261 ^@ http://purl.uniprot.org/uniprot/F7CDA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100013399 ^@ http://purl.uniprot.org/uniprot/F7E7L5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC100616874 ^@ http://purl.uniprot.org/uniprot/F6SAV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A5F8H431|||http://purl.uniprot.org/uniprot/F6R8A4 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:monDomV1R1220 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100015907 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK29|||http://purl.uniprot.org/uniprot/F7CIV5 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/13616:TIMM17B ^@ http://purl.uniprot.org/uniprot/F6XNC7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:AP2M1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H245 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cell membrane|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules.|||coated pit http://togogenome.org/gene/13616:MALRD1 ^@ http://purl.uniprot.org/uniprot/F7AYR0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PLET1 ^@ http://purl.uniprot.org/uniprot/F6UHU8 ^@ Function ^@ Modulates leading keratinocyte migration and cellular adhesion to matrix proteins during a wound-healing response and promotes wound repair. May play a role during trichilemmal differentiation of the hair follicle. http://togogenome.org/gene/13616:FAM234A ^@ http://purl.uniprot.org/uniprot/A0A5F8GJC5 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/13616:SNUPN ^@ http://purl.uniprot.org/uniprot/F7CUM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snurportin family.|||Cytoplasm|||Functions as an U snRNP-specific nuclear import adapter. Involved in the trimethylguanosine (m3G)-cap-dependent nuclear import of U snRNPs. Binds specifically to the terminal m3G-cap U snRNAs.|||Nucleus http://togogenome.org/gene/13616:TYK2 ^@ http://purl.uniprot.org/uniprot/F6V3I2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/13616:PPP3CA ^@ http://purl.uniprot.org/uniprot/A0A5F8G7J7|||http://purl.uniprot.org/uniprot/F7DKU1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/13616:MRPS18A ^@ http://purl.uniprot.org/uniprot/F7DYS6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/13616:MED30 ^@ http://purl.uniprot.org/uniprot/F6VFA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/13616:CHUK ^@ http://purl.uniprot.org/uniprot/F6YS11 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TPPP3 ^@ http://purl.uniprot.org/uniprot/F6WFW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPPP family.|||cytoskeleton http://togogenome.org/gene/13616:UGCG ^@ http://purl.uniprot.org/uniprot/F7FHW3 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/13616:CRMP1 ^@ http://purl.uniprot.org/uniprot/F7DXA3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/13616:monDomV1R1264 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CLIC3 ^@ http://purl.uniprot.org/uniprot/F6S4Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/13616:TDP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEF8|||http://purl.uniprot.org/uniprot/K7E4B3 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/13616:MYH7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8U6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:AKR1A1 ^@ http://purl.uniprot.org/uniprot/F7GDV9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:VARS ^@ http://purl.uniprot.org/uniprot/F7B9X7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:LOC103092017 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYE3|||http://purl.uniprot.org/uniprot/A0A5F8HGG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/13616:GCM1 ^@ http://purl.uniprot.org/uniprot/F6ZME1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NONO ^@ http://purl.uniprot.org/uniprot/F6RSW7 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/13616:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRG3|||http://purl.uniprot.org/uniprot/A0A5F8GWP9|||http://purl.uniprot.org/uniprot/F6QMV8 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/13616:PROSC ^@ http://purl.uniprot.org/uniprot/F7FW91 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/13616:GBA ^@ http://purl.uniprot.org/uniprot/F6VKK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/13616:RASSF5 ^@ http://purl.uniprot.org/uniprot/F6QW39 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:ECHS1 ^@ http://purl.uniprot.org/uniprot/F7ESK8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/13616:LOC100028976 ^@ http://purl.uniprot.org/uniprot/F6UAW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:WLS ^@ http://purl.uniprot.org/uniprot/F6T8H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:F13B ^@ http://purl.uniprot.org/uniprot/F6WU37 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NDUFB5 ^@ http://purl.uniprot.org/uniprot/F7G3T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ATP5C1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G633|||http://purl.uniprot.org/uniprot/F7CHH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and the central stalk which is part of the complex rotary element. The gamma subunit protrudes into the catalytic domain formed of alpha(3)beta(3). Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/13616:PI4K2B ^@ http://purl.uniprot.org/uniprot/F6QMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily.|||Membrane http://togogenome.org/gene/13616:HSPA9 ^@ http://purl.uniprot.org/uniprot/F7G4T9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:GGCX ^@ http://purl.uniprot.org/uniprot/F6Z5J6 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Mediates the vitamin K-dependent carboxylation of glutamate residues to calcium-binding gamma-carboxyglutamate (Gla) residues with the concomitant conversion of the reduced hydroquinone form of vitamin K to vitamin K epoxide.|||Membrane http://togogenome.org/gene/13616:CTSW ^@ http://purl.uniprot.org/uniprot/F7EY12 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:LOC100018206 ^@ http://purl.uniprot.org/uniprot/F6V827 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NANOS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H579 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/13616:CYFIP2 ^@ http://purl.uniprot.org/uniprot/F6VDV5 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/13616:LOC100021550 ^@ http://purl.uniprot.org/uniprot/F6VIN8 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/13616:MYT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC68|||http://purl.uniprot.org/uniprot/A0A5F8HCF7|||http://purl.uniprot.org/uniprot/F6VKU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/13616:PHC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H689 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FNIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G300|||http://purl.uniprot.org/uniprot/F6Y4V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:AKT3 ^@ http://purl.uniprot.org/uniprot/F7GEK1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/13616:MAPK3 ^@ http://purl.uniprot.org/uniprot/F7EI48 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola http://togogenome.org/gene/13616:LOC100618014 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SF3B5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFZ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/13616:LOC100021883 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:STXBP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/13616:CEBPD ^@ http://purl.uniprot.org/uniprot/F7DQJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100018739 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:PAQR7 ^@ http://purl.uniprot.org/uniprot/F7C2X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIG5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:GCLM ^@ http://purl.uniprot.org/uniprot/A0A5F8H8N6 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/13616:TK1 ^@ http://purl.uniprot.org/uniprot/F6SP09 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/13616:GSTCD ^@ http://purl.uniprot.org/uniprot/F6ZAN7 ^@ Similarity ^@ Belongs to the GSTCD family. http://togogenome.org/gene/13616:HMOX1 ^@ http://purl.uniprot.org/uniprot/F7CK49 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/13616:MRAP2 ^@ http://purl.uniprot.org/uniprot/F6PPU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A5F8G329|||http://purl.uniprot.org/uniprot/F6S463 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/13616:LOC100618665 ^@ http://purl.uniprot.org/uniprot/F7BX16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:BST1 ^@ http://purl.uniprot.org/uniprot/F6ZFG5 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/13616:PIGM ^@ http://purl.uniprot.org/uniprot/F6USQ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/13616:ILF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE55|||http://purl.uniprot.org/uniprot/F6XCW7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIW6|||http://purl.uniprot.org/uniprot/F7C2B7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:CLVS1 ^@ http://purl.uniprot.org/uniprot/F7CDW7 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/13616:LGMN ^@ http://purl.uniprot.org/uniprot/F6YEF8 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/13616:TPRG1L ^@ http://purl.uniprot.org/uniprot/K7DZC4 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/13616:MRPL33 ^@ http://purl.uniprot.org/uniprot/F6ZV32 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/13616:RGMA ^@ http://purl.uniprot.org/uniprot/F7G293 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:OSBPL11 ^@ http://purl.uniprot.org/uniprot/F6QV52 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:TAF1B ^@ http://purl.uniprot.org/uniprot/F6YN56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||Component of RNA polymerase I core factor complex that acts as a GTF2B/TFIIB-like factor and plays a key role in multiple steps during transcription initiation such as pre-initiation complex (PIC) assembly and postpolymerase recruitment events in polymerase I (Pol I) transcription. Binds rDNA promoters and plays a role in Pol I recruitment as a component of the SL1/TIF-IB complex and, possibly, directly through its interaction with RRN3.|||nucleolus http://togogenome.org/gene/13616:HMGN2 ^@ http://purl.uniprot.org/uniprot/F7GFJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/13616:LOC100026355 ^@ http://purl.uniprot.org/uniprot/F6XCC9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:OTUB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCF4|||http://purl.uniprot.org/uniprot/A0A5F8HBX7 ^@ Similarity ^@ Belongs to the peptidase C65 family. http://togogenome.org/gene/13616:ANAPC13 ^@ http://purl.uniprot.org/uniprot/F7B352 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/13616:BCL7B ^@ http://purl.uniprot.org/uniprot/F6UB62 ^@ Similarity ^@ Belongs to the BCL7 family. http://togogenome.org/gene/13616:ANAPC15 ^@ http://purl.uniprot.org/uniprot/F6Z9Y0 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/13616:ITPKB ^@ http://purl.uniprot.org/uniprot/F7F126 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/13616:LAP3 ^@ http://purl.uniprot.org/uniprot/F7BHR0 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/13616:KIF13A ^@ http://purl.uniprot.org/uniprot/A0A5F8HK25|||http://purl.uniprot.org/uniprot/F6S7Y0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:DDX43 ^@ http://purl.uniprot.org/uniprot/F7GCW4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:LOC100010381 ^@ http://purl.uniprot.org/uniprot/F6U2E9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:LOC100617479 ^@ http://purl.uniprot.org/uniprot/F7EI98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:STC2 ^@ http://purl.uniprot.org/uniprot/F7BSU8 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/13616:monDomV1R1272 ^@ http://purl.uniprot.org/uniprot/A0A5F8HED0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RRN3 ^@ http://purl.uniprot.org/uniprot/F6QIM4 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/13616:MBOAT2 ^@ http://purl.uniprot.org/uniprot/F7E818 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100018630 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDC6 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/13616:OTOP2 ^@ http://purl.uniprot.org/uniprot/F6UF84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100016060 ^@ http://purl.uniprot.org/uniprot/F7GH03 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:UCKL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEJ6|||http://purl.uniprot.org/uniprot/A0A5F8H2N1|||http://purl.uniprot.org/uniprot/F6Y033 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/13616:GABRA5 ^@ http://purl.uniprot.org/uniprot/F7C2S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:GJC1 ^@ http://purl.uniprot.org/uniprot/F6T5B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins. Interacts with CNST.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:PTH2R ^@ http://purl.uniprot.org/uniprot/A0A5F8HFW8|||http://purl.uniprot.org/uniprot/F7BR47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PPP4C ^@ http://purl.uniprot.org/uniprot/F7E0S5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/13616:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHJ8|||http://purl.uniprot.org/uniprot/A0A5F8HHU2 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/13616:UFL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF34 ^@ Similarity ^@ Belongs to the UFL1 family. http://togogenome.org/gene/13616:HTR1F ^@ http://purl.uniprot.org/uniprot/A0A5F8H0E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/13616:FAM229A ^@ http://purl.uniprot.org/uniprot/F6ZTY7 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/13616:RPS7 ^@ http://purl.uniprot.org/uniprot/F7FKL8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||Required for rRNA maturation. http://togogenome.org/gene/13616:PLK1 ^@ http://purl.uniprot.org/uniprot/F7F258 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/13616:LOC100015414 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Y9|||http://purl.uniprot.org/uniprot/F7CVP0 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/13616:IER3IP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHG0 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/13616:LTN1 ^@ http://purl.uniprot.org/uniprot/F6RK02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/13616:SST ^@ http://purl.uniprot.org/uniprot/F7FTG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatostatin family.|||Secreted http://togogenome.org/gene/13616:UGP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI35|||http://purl.uniprot.org/uniprot/F6PIH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/13616:HEXDC ^@ http://purl.uniprot.org/uniprot/F6SI50 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/13616:STK17B ^@ http://purl.uniprot.org/uniprot/F7FU71 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:CSNK2B ^@ http://purl.uniprot.org/uniprot/A0A5F8GWR8|||http://purl.uniprot.org/uniprot/A0A5F8HE66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Participates in Wnt signaling.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/13616:FITM1 ^@ http://purl.uniprot.org/uniprot/F7GBQ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. FIT1 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays an important role in the formation of lipid droplets (LDs), which are storage organelles at the center of lipid and energy homeostasis. Directly binds to diacylglycerol (DAGs) and triacylglycerol. http://togogenome.org/gene/13616:CALR ^@ http://purl.uniprot.org/uniprot/F6QXX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen|||Monomer. http://togogenome.org/gene/13616:ARFGEF1 ^@ http://purl.uniprot.org/uniprot/F7AWY8 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/13616:GALM ^@ http://purl.uniprot.org/uniprot/F6PGL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the aldose epimerase family.|||Monomer.|||Mutarotase that catalyzes the interconversion of beta-D-galactose and alpha-D-galactose during galactose metabolism. http://togogenome.org/gene/13616:TGFBR2 ^@ http://purl.uniprot.org/uniprot/F7CFN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/13616:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/F7C6K7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PEX2 ^@ http://purl.uniprot.org/uniprot/F6U9L6 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/13616:GLIPR1 ^@ http://purl.uniprot.org/uniprot/F7A3E5 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/13616:LOC103106071 ^@ http://purl.uniprot.org/uniprot/F7FTI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:STRIP2 ^@ http://purl.uniprot.org/uniprot/F7E828 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/13616:LOC103095510 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUA5 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A5F8GEQ2|||http://purl.uniprot.org/uniprot/A0A5F8H9J9|||http://purl.uniprot.org/uniprot/A0A5F8HD03|||http://purl.uniprot.org/uniprot/F6QCP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/13616:FOXO3 ^@ http://purl.uniprot.org/uniprot/F7B7W4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC28A3 ^@ http://purl.uniprot.org/uniprot/F7F2P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/13616:HOMER3 ^@ http://purl.uniprot.org/uniprot/F7AAG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/13616:CKAP2L ^@ http://purl.uniprot.org/uniprot/F6X5H0 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/13616:JUP ^@ http://purl.uniprot.org/uniprot/F7DNP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Common junctional plaque protein. The membrane-associated plaques are architectural elements in an important strategic position to influence the arrangement and function of both the cytoskeleton and the cells within the tissue. The presence of plakoglobin in both the desmosomes and in the intermediate junctions suggests that it plays a central role in the structure and function of submembranous plaques. Acts as a substrate for VE-PTP and is required by it to stimulate VE-cadherin function in endothelial cells. Can replace beta-catenin in E-cadherin/catenin adhesion complexes which are proposed to couple cadherins to the actin cytoskeleton.|||Membrane|||adherens junction|||desmosome http://togogenome.org/gene/13616:HEATR5B ^@ http://purl.uniprot.org/uniprot/A0A5F8H7P6 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/13616:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB99 ^@ Subcellular Location Annotation ^@ cytoskeleton|||cytosol http://togogenome.org/gene/13616:PDE5A ^@ http://purl.uniprot.org/uniprot/F7GAS1 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:UFD1L ^@ http://purl.uniprot.org/uniprot/F6TB32 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/13616:TMEM55A ^@ http://purl.uniprot.org/uniprot/F7FZZ9 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/13616:CLTC ^@ http://purl.uniprot.org/uniprot/F7ATX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/13616:LOC100030680 ^@ http://purl.uniprot.org/uniprot/F6YEH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:LPCAT4 ^@ http://purl.uniprot.org/uniprot/F6WZ01 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:TMEM98 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/13616:CLK1 ^@ http://purl.uniprot.org/uniprot/F7BXF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100019690 ^@ http://purl.uniprot.org/uniprot/F6YH14 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:PHTF1 ^@ http://purl.uniprot.org/uniprot/F6S9T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SNRPF ^@ http://purl.uniprot.org/uniprot/F7GFW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/13616:T2R41 ^@ http://purl.uniprot.org/uniprot/Q2AB86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:HN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SEMA3A ^@ http://purl.uniprot.org/uniprot/F6Q9V8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:AMPD2 ^@ http://purl.uniprot.org/uniprot/F6W0Z6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/13616:CFDP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGI5 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/13616:PPM1G ^@ http://purl.uniprot.org/uniprot/F7F0V5 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/13616:FFAR1 ^@ http://purl.uniprot.org/uniprot/F6W8J7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TAF7L ^@ http://purl.uniprot.org/uniprot/A0A5F8GHF7|||http://purl.uniprot.org/uniprot/F7GDZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/13616:PALMD ^@ http://purl.uniprot.org/uniprot/A0A5F8GCZ2|||http://purl.uniprot.org/uniprot/F7DTP3 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/13616:PPP2CB ^@ http://purl.uniprot.org/uniprot/F7CP86 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/13616:LMX1A ^@ http://purl.uniprot.org/uniprot/F7CIX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PGP ^@ http://purl.uniprot.org/uniprot/F6PJ49 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/13616:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/F7G310 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:NHSL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHA7|||http://purl.uniprot.org/uniprot/F6SKV8 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/13616:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVL9|||http://purl.uniprot.org/uniprot/A0A5F8H5I4|||http://purl.uniprot.org/uniprot/A0A5F8HBI3|||http://purl.uniprot.org/uniprot/A0A5F8HCJ2|||http://purl.uniprot.org/uniprot/A0A5F8HLP0|||http://purl.uniprot.org/uniprot/F7GGK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/13616:ME1 ^@ http://purl.uniprot.org/uniprot/F6QV43 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/13616:OGG1 ^@ http://purl.uniprot.org/uniprot/F6ZEE7 ^@ Function|||Similarity ^@ Belongs to the type-1 OGG1 family.|||DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N-methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion. http://togogenome.org/gene/13616:RAB4B ^@ http://purl.uniprot.org/uniprot/F7GI49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/13616:LOC100017631 ^@ http://purl.uniprot.org/uniprot/F7DI19 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A5F8G4F8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:TMEM45B ^@ http://purl.uniprot.org/uniprot/F7C2F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/13616:NSMCE2 ^@ http://purl.uniprot.org/uniprot/K7E4G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/13616:LOC100028592 ^@ http://purl.uniprot.org/uniprot/F7AKM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LPGAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGG2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:SLU7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/13616:EDC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/13616:NUP133 ^@ http://purl.uniprot.org/uniprot/F7G2C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin Nup133 family.|||nuclear pore complex http://togogenome.org/gene/13616:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9Y0|||http://purl.uniprot.org/uniprot/A0A5F8GRU6|||http://purl.uniprot.org/uniprot/F6Y7R9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/13616:LOC100015833 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/13616:RAD21L1 ^@ http://purl.uniprot.org/uniprot/F6Z2B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/13616:LOC100017183 ^@ http://purl.uniprot.org/uniprot/F7A3G7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/13616:BLOC1S6 ^@ http://purl.uniprot.org/uniprot/F6ZSG2 ^@ Function|||Similarity ^@ Belongs to the BLOC1S6 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. May play a role in intracellular vesicle trafficking, particularly in the vesicle-docking and fusion process. http://togogenome.org/gene/13616:TSEN54 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Q3|||http://purl.uniprot.org/uniprot/F7DWA7 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/13616:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/13616:CDPF1 ^@ http://purl.uniprot.org/uniprot/F6V618 ^@ Similarity ^@ Belongs to the CDPF1 family. http://togogenome.org/gene/13616:ELF5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H773 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:AURKA ^@ http://purl.uniprot.org/uniprot/F7ASA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/13616:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:CCKBR ^@ http://purl.uniprot.org/uniprot/A0A5F8G2V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EIF4A1 ^@ http://purl.uniprot.org/uniprot/F6UEF7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/13616:SERINC2 ^@ http://purl.uniprot.org/uniprot/F6V419 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/13616:PSMD3 ^@ http://purl.uniprot.org/uniprot/F7CS51 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/13616:KCNH5 ^@ http://purl.uniprot.org/uniprot/F7GL29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PMF1 ^@ http://purl.uniprot.org/uniprot/F6ZUU9 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/13616:PIAS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8A5|||http://purl.uniprot.org/uniprot/A0A5F8GDT2|||http://purl.uniprot.org/uniprot/F7B6F8 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/13616:CAMSAP1 ^@ http://purl.uniprot.org/uniprot/F7E1H7 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/13616:LOC100024209 ^@ http://purl.uniprot.org/uniprot/F6YHU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/13616:PQLC2 ^@ http://purl.uniprot.org/uniprot/F7B3W8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:monDomV1R1221 ^@ http://purl.uniprot.org/uniprot/F7FEJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100016508 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/13616:E2F5 ^@ http://purl.uniprot.org/uniprot/F6WF79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1233 ^@ http://purl.uniprot.org/uniprot/F7BV07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/13616:XKR8 ^@ http://purl.uniprot.org/uniprot/F7FWH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/13616:FAM171A1 ^@ http://purl.uniprot.org/uniprot/F6Y546 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/13616:STX7 ^@ http://purl.uniprot.org/uniprot/F7E0Z1 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/13616:MGAT5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/13616:HSPD1 ^@ http://purl.uniprot.org/uniprot/F7GF46 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/13616:MFSD14B ^@ http://purl.uniprot.org/uniprot/F6S9C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/13616:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/F6YKR4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/13616:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A5F8GDZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/13616:LBR ^@ http://purl.uniprot.org/uniprot/F6TKZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/13616:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVX4|||http://purl.uniprot.org/uniprot/F7CEB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC13A2 ^@ http://purl.uniprot.org/uniprot/F7C4K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/13616:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYN7 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/13616:COPG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5D4|||http://purl.uniprot.org/uniprot/F7F762 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/13616:ACSL5 ^@ http://purl.uniprot.org/uniprot/F6VQ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:TP53INP2 ^@ http://purl.uniprot.org/uniprot/F7DHX4 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/13616:TUBB4B ^@ http://purl.uniprot.org/uniprot/A0A5F8HDJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:DZIP1L ^@ http://purl.uniprot.org/uniprot/F7GCS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||centriole|||cilium basal body http://togogenome.org/gene/13616:CPLX1 ^@ http://purl.uniprot.org/uniprot/F6VKP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/13616:WNT2B ^@ http://purl.uniprot.org/uniprot/F7GH85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:DDX6 ^@ http://purl.uniprot.org/uniprot/F7DTA2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A5F8G322|||http://purl.uniprot.org/uniprot/F7FA92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/13616:TXNIP ^@ http://purl.uniprot.org/uniprot/K7E0W4 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/13616:AMOT ^@ http://purl.uniprot.org/uniprot/F6ZEG2 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/13616:ENSA ^@ http://purl.uniprot.org/uniprot/F6ZMD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/13616:PFDN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G255|||http://purl.uniprot.org/uniprot/F7E8R4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/13616:ACTR1B ^@ http://purl.uniprot.org/uniprot/F7GIQ3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:EHD3 ^@ http://purl.uniprot.org/uniprot/F6VZL7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/13616:FAM210A ^@ http://purl.uniprot.org/uniprot/A0A5F8HCL9 ^@ Similarity ^@ Belongs to the FAM210 family. http://togogenome.org/gene/13616:TMEM184A ^@ http://purl.uniprot.org/uniprot/F7B328 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NME9 ^@ http://purl.uniprot.org/uniprot/F7FRS4 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/13616:SPC24 ^@ http://purl.uniprot.org/uniprot/F7B3S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/13616:ROMO1 ^@ http://purl.uniprot.org/uniprot/F7BX66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:HRH3 ^@ http://purl.uniprot.org/uniprot/F7D2C8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:MYO1C ^@ http://purl.uniprot.org/uniprot/A0A5F8GAW6|||http://purl.uniprot.org/uniprot/F6SRM2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:PDCD4 ^@ http://purl.uniprot.org/uniprot/F7AUR7 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/13616:RAB14 ^@ http://purl.uniprot.org/uniprot/F7DD10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/13616:LOC100028693 ^@ http://purl.uniprot.org/uniprot/F7ET94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MRPS18C ^@ http://purl.uniprot.org/uniprot/F6Z9N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Mitochondrion http://togogenome.org/gene/13616:TMEM65 ^@ http://purl.uniprot.org/uniprot/F6SNF7|||http://purl.uniprot.org/uniprot/K7E246 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ADAMTS5 ^@ http://purl.uniprot.org/uniprot/F6RJX5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:TIMM22 ^@ http://purl.uniprot.org/uniprot/F6UAF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ADCK3 ^@ http://purl.uniprot.org/uniprot/F7GCL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane|||Mitochondrion http://togogenome.org/gene/13616:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G549 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAPGEF2 family.|||Cell junction|||Endosome|||Late endosome|||perinuclear region http://togogenome.org/gene/13616:TM9SF1 ^@ http://purl.uniprot.org/uniprot/F7EFZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/13616:DPYSL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2L5|||http://purl.uniprot.org/uniprot/F7DMI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Homotetramer, and heterotetramer with CRMP1, DPYSL3, DPYSL4 or DPYSL5. Interacts through its C-terminus with the C-terminus of CYFIP1/SRA1. Interacts with HTR4. Interacts with CLN6. Interacts with MICALL1.|||Plays a role in neuronal development and polarity, as well as in axon growth and guidance, neuronal growth cone collapse and cell migration. Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. May play a role in endocytosis. http://togogenome.org/gene/13616:ARPC1A ^@ http://purl.uniprot.org/uniprot/F7BZM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/13616:PI4KB ^@ http://purl.uniprot.org/uniprot/A0A5F8H4E4|||http://purl.uniprot.org/uniprot/F7DVF5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/13616:CHEK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJI8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/13616:COQ7 ^@ http://purl.uniprot.org/uniprot/F7B5L7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:IKBKAP ^@ http://purl.uniprot.org/uniprot/F6S334 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:ECHDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3J6|||http://purl.uniprot.org/uniprot/F7GFX1 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/13616:RHCE ^@ http://purl.uniprot.org/uniprot/F6QL35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/13616:SLC25A48 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI58|||http://purl.uniprot.org/uniprot/F7A5G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:SFT2D3 ^@ http://purl.uniprot.org/uniprot/F6UC97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/13616:FOXI1 ^@ http://purl.uniprot.org/uniprot/F6PV64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMEM147 ^@ http://purl.uniprot.org/uniprot/F6VBQ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:EML5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7C4|||http://purl.uniprot.org/uniprot/F6WDF5 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/13616:CDK5RAP2 ^@ http://purl.uniprot.org/uniprot/F7GLC9 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/13616:POU3F1 ^@ http://purl.uniprot.org/uniprot/F7FHU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/13616:ELF4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:FSCN1 ^@ http://purl.uniprot.org/uniprot/F6ZF84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/13616:LOC103104714 ^@ http://purl.uniprot.org/uniprot/A0A5F8G703 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100018050 ^@ http://purl.uniprot.org/uniprot/F6Y2D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LCN15 ^@ http://purl.uniprot.org/uniprot/F6VYX5 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAJ3|||http://purl.uniprot.org/uniprot/F6PGY0 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/13616:PIGX ^@ http://purl.uniprot.org/uniprot/F7CU66 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NTN3 ^@ http://purl.uniprot.org/uniprot/F6SLT4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ENPP6 ^@ http://purl.uniprot.org/uniprot/F6W5E7 ^@ Similarity ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. http://togogenome.org/gene/13616:PSMB1 ^@ http://purl.uniprot.org/uniprot/F7F3A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A5F8GMR7|||http://purl.uniprot.org/uniprot/A0A5F8GT00|||http://purl.uniprot.org/uniprot/A0A5F8H7I0|||http://purl.uniprot.org/uniprot/A0A5F8H894|||http://purl.uniprot.org/uniprot/F7G3U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:KCNH8 ^@ http://purl.uniprot.org/uniprot/F7G6S7 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/13616:LOC100021720 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CPNE7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV78 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/13616:LOC100027993 ^@ http://purl.uniprot.org/uniprot/F7AUS6 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/13616:DVL1 ^@ http://purl.uniprot.org/uniprot/F7G276 ^@ Similarity ^@ Belongs to the DSH family. http://togogenome.org/gene/13616:SLC6A15 ^@ http://purl.uniprot.org/uniprot/F7F542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/13616:IFN3 ^@ http://purl.uniprot.org/uniprot/A8E6E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:GJB6 ^@ http://purl.uniprot.org/uniprot/F6WYP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:CMTM8 ^@ http://purl.uniprot.org/uniprot/F7BW18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HSP90B1 ^@ http://purl.uniprot.org/uniprot/F7DFT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/13616:LOC100021543 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103093560 ^@ http://purl.uniprot.org/uniprot/F6Y6H3 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/13616:NAE1 ^@ http://purl.uniprot.org/uniprot/F7C8D9 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-NAE1 E1 enzyme. E1 activates NEDD8 by first adenylating its C-terminal glycine residue with ATP, thereafter linking this residue to the side chain of the catalytic cysteine, yielding a NEDD8-UBA3 thioester and free AMP. E1 finally transfers NEDD8 to the catalytic cysteine of UBE2M. http://togogenome.org/gene/13616:NOXA1 ^@ http://purl.uniprot.org/uniprot/F6RVX3 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/13616:HTRA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT06 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/13616:INPP5D ^@ http://purl.uniprot.org/uniprot/A0A5F8GEZ3|||http://purl.uniprot.org/uniprot/A0A5F8HIU2|||http://purl.uniprot.org/uniprot/F7GAI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family.|||Membrane http://togogenome.org/gene/13616:MIEF2 ^@ http://purl.uniprot.org/uniprot/F6QNZ2 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:HTRA3 ^@ http://purl.uniprot.org/uniprot/F6ZXS4 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/13616:SLC6A12 ^@ http://purl.uniprot.org/uniprot/F6QVR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A12 subfamily.|||Interacts with LIN7C.|||Membrane|||Transports betaine and GABA. May have a role in regulation of GABAergic transmission in the brain through the reuptake of GABA into presynaptic terminals, as well as in osmotic regulation. http://togogenome.org/gene/13616:LOC100032740 ^@ http://purl.uniprot.org/uniprot/F6W9F0 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/13616:LOC100028676 ^@ http://purl.uniprot.org/uniprot/F7AKN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PSKH2 ^@ http://purl.uniprot.org/uniprot/F7ELA1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:DNAAF2 ^@ http://purl.uniprot.org/uniprot/F6S6H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PIH1 family. Kintoun subfamily.|||Cytoplasm|||Interacts with CFAP300. Interacts with DNAI2 and HSPA1A. Interacts with DYX1C1. Interacts with PIH1D3.|||Required for cytoplasmic pre-assembly of axonemal dyneins, thereby playing a central role in motility in cilia and flagella. Involved in pre-assembly of dynein arm complexes in the cytoplasm before intraflagellar transport loads them for the ciliary compartment. http://togogenome.org/gene/13616:LOC100012726 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJR1 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/13616:LOC100016983 ^@ http://purl.uniprot.org/uniprot/F7F6C6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Inflammasome http://togogenome.org/gene/13616:SUV39H2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1N6|||http://purl.uniprot.org/uniprot/F6VMZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/13616:UGGT1 ^@ http://purl.uniprot.org/uniprot/F7B290 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:SH2B3 ^@ http://purl.uniprot.org/uniprot/F6VBG4 ^@ Similarity ^@ Belongs to the SH2B adapter family. http://togogenome.org/gene/13616:MOS ^@ http://purl.uniprot.org/uniprot/F6RB09 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:EPHX1 ^@ http://purl.uniprot.org/uniprot/F6SN50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:LOC100015203 ^@ http://purl.uniprot.org/uniprot/F6WM29 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/13616:FBP2 ^@ http://purl.uniprot.org/uniprot/F7EJ99 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/13616:STK38 ^@ http://purl.uniprot.org/uniprot/F7C3H3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:P4HA1 ^@ http://purl.uniprot.org/uniprot/F6YBC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:LOC100016464 ^@ http://purl.uniprot.org/uniprot/F7FXB8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:PYY ^@ http://purl.uniprot.org/uniprot/F7GDQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/13616:USP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLS6|||http://purl.uniprot.org/uniprot/F7C8N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/13616:LDB2 ^@ http://purl.uniprot.org/uniprot/F6ZHF4 ^@ Similarity ^@ Belongs to the LDB family. http://togogenome.org/gene/13616:ANKRD13A ^@ http://purl.uniprot.org/uniprot/F6SX00 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/13616:DTNB ^@ http://purl.uniprot.org/uniprot/A0A5F8G2N2|||http://purl.uniprot.org/uniprot/A0A5F8GMX5|||http://purl.uniprot.org/uniprot/F7F0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100014733 ^@ http://purl.uniprot.org/uniprot/F6SW40 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/13616:USE1 ^@ http://purl.uniprot.org/uniprot/F7G5D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100015328 ^@ http://purl.uniprot.org/uniprot/F7D750 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:RBP7 ^@ http://purl.uniprot.org/uniprot/F7E2J7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:TRHR ^@ http://purl.uniprot.org/uniprot/F7AUF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for thyrotropin-releasing hormone (TRH). Upon ligand binding, this G-protein-coupled receptor triggers activation of the phosphatidylinositol (IP3)-calcium-protein kinase C (PKC) pathway. http://togogenome.org/gene/13616:LOC100012472 ^@ http://purl.uniprot.org/uniprot/F6WL75 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:LOC100618039 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOXL1 ^@ http://purl.uniprot.org/uniprot/F6RXA9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/13616:HPS5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFH8|||http://purl.uniprot.org/uniprot/F7B866 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/13616:HHAT ^@ http://purl.uniprot.org/uniprot/F7FUH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:BNIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3B7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100028379 ^@ http://purl.uniprot.org/uniprot/F6URR5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:SH3GL2 ^@ http://purl.uniprot.org/uniprot/F7BZ08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/13616:FAM163A ^@ http://purl.uniprot.org/uniprot/F7AI30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/13616:AP1G2 ^@ http://purl.uniprot.org/uniprot/F6YVC1 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:BTF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF00 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/13616:RNF13 ^@ http://purl.uniprot.org/uniprot/F6T2X0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CLDN15 ^@ http://purl.uniprot.org/uniprot/F7ER03 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:LOC100616785 ^@ http://purl.uniprot.org/uniprot/F7ER49 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:TMEM55B ^@ http://purl.uniprot.org/uniprot/F7E374 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the hydrolysis of phosphatidylinositol-4,5-bisphosphate (PtdIns-4,5-P2) to phosphatidylinositol-4-phosphate (PtdIns-4-P).|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/13616:LCNL1 ^@ http://purl.uniprot.org/uniprot/K7E5E8 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:VDAC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBY8|||http://purl.uniprot.org/uniprot/F6VI43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic mitochondrial porin family.|||Forms a channel through the mitochondrial outer membrane that allows diffusion of small hydrophilic molecules.|||Interacts with ARMC12 in a TBC1D21-dependent manner.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:LOC100018242 ^@ http://purl.uniprot.org/uniprot/F6UWP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:LOC100020352 ^@ http://purl.uniprot.org/uniprot/F6ZKK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:LOC100013884 ^@ http://purl.uniprot.org/uniprot/F6TNB5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:HOXD8 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJA7|||http://purl.uniprot.org/uniprot/F7A9D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MEF2C ^@ http://purl.uniprot.org/uniprot/A0A5F8GFY9|||http://purl.uniprot.org/uniprot/A0A5F8H3R3|||http://purl.uniprot.org/uniprot/A0A5F8H4C6|||http://purl.uniprot.org/uniprot/F7FXI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100030569 ^@ http://purl.uniprot.org/uniprot/F7FRF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Oxidizes L-gulono-1,4-lactone to hydrogen peroxide and L-xylo-hexulonolactone which spontaneously isomerizes to L-ascorbate. http://togogenome.org/gene/13616:LOC100028243 ^@ http://purl.uniprot.org/uniprot/F7ELD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/13616:LOC103094062 ^@ http://purl.uniprot.org/uniprot/K7E0X3 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:STAT4 ^@ http://purl.uniprot.org/uniprot/F7CW94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:NIT2 ^@ http://purl.uniprot.org/uniprot/F7GEI7 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/13616:MRPS14 ^@ http://purl.uniprot.org/uniprot/F6SVT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/13616:PLB1 ^@ http://purl.uniprot.org/uniprot/Q06HQ7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the 'GDSL' lipolytic enzyme family. Phospholipase B1 subfamily.|||Calcium-independent membrane-associated phospholipase that catalyzes complete diacylation of phospholipids by hydrolyzing both sn-1 and sn-2 fatty acyl chains attached to the glycerol backbone (phospholipase B activity) (By similarity). Has dual phospholipase and lysophospholipase activities toward diacylphospholipids. Preferentially cleaves sn-2 ester bonds over sn-1 bonds. Acts as a lipase toward glycerolipid substrates (By similarity). Hydrolyzes fatty acyl chains of diacylglycerols with preference for the sn-2 position and of triacylglycerols with not positional selectivity (By similarity). May also hydrolyze long chain retinyl esters such as retinyl palmitate (By similarity). May contribute to digestion of dietary phospholipids, glycerolipids and retinoids, facilitating lipid absorption at the brush border (By similarity).|||Repeat 2 contains the catalytic domain.|||Undergoes proteolytic cleavage in the ileum. http://togogenome.org/gene/13616:SPIRE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPS7|||http://purl.uniprot.org/uniprot/F7CBF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/13616:ACER3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H809|||http://purl.uniprot.org/uniprot/F7A1V8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LAMP2 ^@ http://purl.uniprot.org/uniprot/F6W221 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/13616:LOC100019659 ^@ http://purl.uniprot.org/uniprot/K7E294 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/13616:LOC100619324 ^@ http://purl.uniprot.org/uniprot/F6T9S7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PMG family.|||In the hair cortex, hair keratin intermediate filaments are embedded in an interfilamentous matrix, consisting of hair keratin-associated proteins (KRTAP), which are essential for the formation of a rigid and resistant hair shaft through their extensive disulfide bond cross-linking with abundant cysteine residues of hair keratins. The matrix proteins include the high-sulfur and high-glycine-tyrosine keratins.|||Interacts with hair keratins. http://togogenome.org/gene/13616:VN2R501 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMF8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AP1M2 ^@ http://purl.uniprot.org/uniprot/F6U1G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/13616:UCK1 ^@ http://purl.uniprot.org/uniprot/F6PHT3 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/13616:CASP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6X9 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:LOC103102267 ^@ http://purl.uniprot.org/uniprot/F6PT66 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/13616:MANEAL ^@ http://purl.uniprot.org/uniprot/K7E623 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100027960 ^@ http://purl.uniprot.org/uniprot/A0A5F8G298 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R624 ^@ http://purl.uniprot.org/uniprot/A0A5F8H261 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RPL22L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTT4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/13616:TUBB3 ^@ http://purl.uniprot.org/uniprot/F6ZPS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:ROCK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cell membrane|||Membrane|||centrosome http://togogenome.org/gene/13616:YIPF5 ^@ http://purl.uniprot.org/uniprot/F6V7Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/13616:CPOX ^@ http://purl.uniprot.org/uniprot/F6XHE8 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/13616:WIPI2 ^@ http://purl.uniprot.org/uniprot/F6UUB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Preautophagosomal structure membrane http://togogenome.org/gene/13616:CYHR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H580|||http://purl.uniprot.org/uniprot/F7F505 ^@ Similarity ^@ Belongs to the ZFTRAF1 family. http://togogenome.org/gene/13616:HSD3B7 ^@ http://purl.uniprot.org/uniprot/F6WZW9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/13616:SLC25A18 ^@ http://purl.uniprot.org/uniprot/F7CUE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:B4GAT1 ^@ http://purl.uniprot.org/uniprot/F7EK79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 49 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:PARVG ^@ http://purl.uniprot.org/uniprot/A0A5F8GP47|||http://purl.uniprot.org/uniprot/F7EHZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||cytoskeleton http://togogenome.org/gene/13616:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A5F8GHV0|||http://purl.uniprot.org/uniprot/F7GHC4 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/13616:ARF5 ^@ http://purl.uniprot.org/uniprot/F6V2X8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/13616:TULP3 ^@ http://purl.uniprot.org/uniprot/F6PR86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/13616:LOC100014148 ^@ http://purl.uniprot.org/uniprot/F6QLJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RNF114 ^@ http://purl.uniprot.org/uniprot/A0A5F8G886|||http://purl.uniprot.org/uniprot/F7A674 ^@ Subunit ^@ Interacts with XAF1, the interaction increases XAF1 stability and proapoptotic effects, and may regulate IFN signaling. http://togogenome.org/gene/13616:LSM7 ^@ http://purl.uniprot.org/uniprot/F6Y2R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/13616:HYLS1 ^@ http://purl.uniprot.org/uniprot/F6UBS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HYLS1 family.|||centriole|||cilium http://togogenome.org/gene/13616:SPG21 ^@ http://purl.uniprot.org/uniprot/F6YT13 ^@ Function ^@ May play a role as a negative regulatory factor in CD4-dependent T-cell activation. http://togogenome.org/gene/13616:STARD3NL ^@ http://purl.uniprot.org/uniprot/A0A5F8GHI8|||http://purl.uniprot.org/uniprot/F6PI71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/13616:VHL ^@ http://purl.uniprot.org/uniprot/F7CGX6 ^@ Similarity ^@ Belongs to the VHL family. http://togogenome.org/gene/13616:OCIAD1 ^@ http://purl.uniprot.org/uniprot/F7EME9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OCIAD1 family.|||Endosome|||Interacts with STAT3.|||Maintains stem cell potency. Increases STAT3 phosphorylation and controls ERK phosphorylation. May act as a scaffold, increasing STAT3 recruitment onto endosomes.|||The OCIA domain is necessary and sufficient for endosomal localization. http://togogenome.org/gene/13616:IFNGR1 ^@ http://purl.uniprot.org/uniprot/F7AIU8 ^@ Similarity ^@ Belongs to the type II cytokine receptor family. http://togogenome.org/gene/13616:DOK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7D3 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/13616:LOC100028235 ^@ http://purl.uniprot.org/uniprot/A0A5F8HED8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADAM15 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNU1|||http://purl.uniprot.org/uniprot/A0A5F8HBV1|||http://purl.uniprot.org/uniprot/F6U405 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100022567 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP SmB/SmN family.|||Nucleus http://togogenome.org/gene/13616:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A5F8HI78|||http://purl.uniprot.org/uniprot/F7CV22 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/13616:CUL4B ^@ http://purl.uniprot.org/uniprot/F6S8D8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:MTIF2 ^@ http://purl.uniprot.org/uniprot/F6T523 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/13616:LOC100020103 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100025505 ^@ http://purl.uniprot.org/uniprot/F6X6X2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:ING1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4R4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/13616:SLC13A1 ^@ http://purl.uniprot.org/uniprot/F6ZWA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100617511 ^@ http://purl.uniprot.org/uniprot/F7EIA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFQ7 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:LOC100015867 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CAP1 ^@ http://purl.uniprot.org/uniprot/F6Z972 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CAP family.|||Cell membrane|||Directly regulates filament dynamics and has been implicated in a number of complex developmental and morphological processes, including mRNA localization and the establishment of cell polarity.|||Homodimer. Binds actin monomers.|||Membrane http://togogenome.org/gene/13616:DTNBP1 ^@ http://purl.uniprot.org/uniprot/F7FK78 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/13616:PSPC1 ^@ http://purl.uniprot.org/uniprot/F7CKP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/13616:NDUFAB1 ^@ http://purl.uniprot.org/uniprot/F7F775 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/13616:SLC28A1 ^@ http://purl.uniprot.org/uniprot/F6WTD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/13616:LOC100013629 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGR0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100016313 ^@ http://purl.uniprot.org/uniprot/F6ZPX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:S1PR5 ^@ http://purl.uniprot.org/uniprot/F6QDA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:NANOG ^@ http://purl.uniprot.org/uniprot/F7BUT7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MYO16 ^@ http://purl.uniprot.org/uniprot/F7AT26 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:SUMF2 ^@ http://purl.uniprot.org/uniprot/F7EQ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:LOC100618787 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GPR180 ^@ http://purl.uniprot.org/uniprot/F7GAZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100618318 ^@ http://purl.uniprot.org/uniprot/F7AWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/13616:SDHB ^@ http://purl.uniprot.org/uniprot/F6YGR0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Iron-sulfur protein (IP) subunit of the succinate dehydrogenase complex (mitochondrial respiratory chain complex II), responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100028935 ^@ http://purl.uniprot.org/uniprot/F7AWV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100013359 ^@ http://purl.uniprot.org/uniprot/F7E7M6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:ACSL6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G641|||http://purl.uniprot.org/uniprot/F6R4I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:DKK2 ^@ http://purl.uniprot.org/uniprot/F6ZB66 ^@ Similarity ^@ Belongs to the dickkopf family. http://togogenome.org/gene/13616:LOC100027566 ^@ http://purl.uniprot.org/uniprot/F6VRB5 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/13616:TIMP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Secreted http://togogenome.org/gene/13616:C4H11orf73 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB63|||http://purl.uniprot.org/uniprot/A0A5F8GNB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/13616:T2R21 ^@ http://purl.uniprot.org/uniprot/Q2AB98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:LOC100011919 ^@ http://purl.uniprot.org/uniprot/F6QTN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/13616:PIGG ^@ http://purl.uniprot.org/uniprot/F6SKB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GER1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/13616:CALHM3 ^@ http://purl.uniprot.org/uniprot/F7F4I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:IGFBP3 ^@ http://purl.uniprot.org/uniprot/F7EV06 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:TOR3A ^@ http://purl.uniprot.org/uniprot/F7FEZ8 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. Torsin subfamily. http://togogenome.org/gene/13616:GPR62 ^@ http://purl.uniprot.org/uniprot/F7CBS2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100026384 ^@ http://purl.uniprot.org/uniprot/F6Z6F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:GCK ^@ http://purl.uniprot.org/uniprot/A0A5F8GL04|||http://purl.uniprot.org/uniprot/F7G8R6 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/13616:MCF2L ^@ http://purl.uniprot.org/uniprot/A0A5F8HA94|||http://purl.uniprot.org/uniprot/A0A5F8HBY1|||http://purl.uniprot.org/uniprot/A0A5F8HD32|||http://purl.uniprot.org/uniprot/F6VVG0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:KRT222 ^@ http://purl.uniprot.org/uniprot/F7FA71 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:LOC100031277 ^@ http://purl.uniprot.org/uniprot/F7EI80 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/13616:ELF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNZ5|||http://purl.uniprot.org/uniprot/F6Q8U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:PRSS16 ^@ http://purl.uniprot.org/uniprot/F6PG02 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/13616:NOB1 ^@ http://purl.uniprot.org/uniprot/F7CYX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||May play a role in mRNA degradation.|||Nucleus http://togogenome.org/gene/13616:CDC42EP2 ^@ http://purl.uniprot.org/uniprot/F7GG65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/13616:MRPL24 ^@ http://purl.uniprot.org/uniprot/F7G680 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/13616:RAG1 ^@ http://purl.uniprot.org/uniprot/Q28463 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAG1 family.|||Binds 1 divalent metal cation per subunit. Mg(2+) or Mn(2+).|||Catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. V(D)J recombination assembles a diverse repertoire of immunoglobulin and T-cell receptor genes in developing B and T-lymphocytes through rearrangement of different V (variable), in some cases D (diversity), and J (joining) gene segments. In the RAG complex, RAG1 mediates the DNA-binding to the conserved recombination signal sequences (RSS) and catalyzes the DNA cleavage activities by introducing a double-strand break between the RSS and the adjacent coding segment. RAG2 is not a catalytic component but is required for all known catalytic activities. DNA cleavage occurs in 2 steps: a first nick is introduced in the top strand immediately upstream of the heptamer, generating a 3'-hydroxyl group that can attack the phosphodiester bond on the opposite strand in a direct transesterification reaction, thereby creating 4 DNA ends: 2 hairpin coding ends and 2 blunt, 5'-phosphorylated ends.|||Homodimer.|||Nucleus|||The NBD (nonamer binding) DNA-binding domain mediates the specific binding to the nonamer RSS motif by forming a tightly interwoven homodimer that binds and synapses 2 nonamer elements, with each NBD making contact with both DNA molecules. Each RSS is composed of well-conserved heptamer (consensus 5'-CACAGTG-3') and nonamer (consensus 5'-ACAAAAACC-3') sequences separated by a spacer of either 12 bp or 23 bp. http://togogenome.org/gene/13616:LDLR ^@ http://purl.uniprot.org/uniprot/F7BQZ9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PTGDS ^@ http://purl.uniprot.org/uniprot/F6XCS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum|||perinuclear region http://togogenome.org/gene/13616:ADCY7 ^@ http://purl.uniprot.org/uniprot/F7G158 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/13616:HHATL ^@ http://purl.uniprot.org/uniprot/F6VVX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GPR31 ^@ http://purl.uniprot.org/uniprot/F7EI33 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100024252 ^@ http://purl.uniprot.org/uniprot/F7EI94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103092471 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDP5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:SPX ^@ http://purl.uniprot.org/uniprot/A0A5F8H2X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spexin family.|||Secreted http://togogenome.org/gene/13616:NANOS1 ^@ http://purl.uniprot.org/uniprot/F7GJT4 ^@ Similarity ^@ Belongs to the nanos family. http://togogenome.org/gene/13616:RNF168 ^@ http://purl.uniprot.org/uniprot/F6XBK7 ^@ Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ According to a well-established model, RNF168 cannot initiate H2A 'Lys-63'-linked ubiquitination and is recruited following RNF8-dependent histone ubiquitination to amplify H2A 'Lys-63'-linked ubiquitination. However, other data suggest that RNF168 is the priming ubiquitin ligase by mediating monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub respectively). These data suggest that RNF168 might be recruited to DSBs sites in a RNF8-dependent manner by binding to non-histone proteins ubiquitinated via 'Lys-63'-linked and initiates monoubiquitination of H2A, which is then amplified by RNF8. Additional evidences are however required to confirm these data.|||Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and H2AX and amplifies the RNF8-dependent H2A ubiquitination, promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Also recruited at DNA interstrand cross-links (ICLs) sites and promotes accumulation of 'Lys-63'-linked ubiquitination of histones H2A and H2AX, leading to recruitment of FAAP20 and Fanconi anemia (FA) complex, followed by interstrand cross-link repair. H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also involved in class switch recombination in immune system, via its role in regulation of DSBs repair. Following DNA damage, promotes the ubiquitination and degradation of JMJD2A/KDM4A in collaboration with RNF8, leading to unmask H4K20me2 mark and promote the recruitment of TP53BP1 at DNA damage sites. Not able to initiate 'Lys-63'-linked ubiquitination in vitro; possibly due to partial occlusion of the UBE2N/UBC13-binding region. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with UBE2N/UBC13.|||Nucleus|||Sumoylated with SUMO1 by PIAS4 in response to double-strand breaks (DSBs).|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs).|||Ubiquitinated. http://togogenome.org/gene/13616:CCDC58 ^@ http://purl.uniprot.org/uniprot/F6PW38 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/13616:VN2R588 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQR7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:MVK ^@ http://purl.uniprot.org/uniprot/F6VQR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/13616:PTP4A1 ^@ http://purl.uniprot.org/uniprot/F7FQJ1 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:HSDL1 ^@ http://purl.uniprot.org/uniprot/F7A6J2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:PIF1 ^@ http://purl.uniprot.org/uniprot/F7ET02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Possesses an intrinsic strand annealing activity.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/13616:ACTG2 ^@ http://purl.uniprot.org/uniprot/F7DQK7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:MTNR1A ^@ http://purl.uniprot.org/uniprot/F7F741 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for melatonin. Likely to mediate the reproductive and circadian actions of melatonin. The activity of this receptor is mediated by pertussis toxin sensitive G proteins that inhibit adenylate cyclase activity.|||Membrane http://togogenome.org/gene/13616:CLIC1 ^@ http://purl.uniprot.org/uniprot/F6UK56 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cell membrane|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane|||Nucleus membrane http://togogenome.org/gene/13616:EIF5 ^@ http://purl.uniprot.org/uniprot/F7C537 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/13616:FIBIN ^@ http://purl.uniprot.org/uniprot/A0A5F8G2K8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FIBIN family.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer; disulfide-linked. Seems to also exist as monomers.|||Secreted http://togogenome.org/gene/13616:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4T0|||http://purl.uniprot.org/uniprot/A0A5F8GY10|||http://purl.uniprot.org/uniprot/A0A5F8HF08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:LOC100616725 ^@ http://purl.uniprot.org/uniprot/F7C278 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DNAJA4 ^@ http://purl.uniprot.org/uniprot/F7GDZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HESX1 ^@ http://purl.uniprot.org/uniprot/F7E2Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/13616:CERS6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7S2|||http://purl.uniprot.org/uniprot/K7E682 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:RNF7 ^@ http://purl.uniprot.org/uniprot/F6QK30 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/13616:USP48 ^@ http://purl.uniprot.org/uniprot/F7EFT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/13616:LOC100011195 ^@ http://purl.uniprot.org/uniprot/F7BV62 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:KIF2A ^@ http://purl.uniprot.org/uniprot/A0A5F8GVS6|||http://purl.uniprot.org/uniprot/F6Y7G9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:SEPT12 ^@ http://purl.uniprot.org/uniprot/F7AHD6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/13616:LRP6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGM1|||http://purl.uniprot.org/uniprot/F6PG65 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the LDLR family.|||Component of the Wnt-Fzd-LRP5-LRP6 complex that triggers beta-catenin signaling through inducing aggregation of receptor-ligand complexes into ribosome-sized signalsomes.|||Homodimer; disulfide-linked. Forms phosphorylated oligomer aggregates on Wnt-signaling.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:AVPR1B ^@ http://purl.uniprot.org/uniprot/F6VJ30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for arginine vasopressin. The activity of this receptor is mediated by G proteins which activate a phosphatidyl-inositol-calcium second messenger system. http://togogenome.org/gene/13616:LOC100023657 ^@ http://purl.uniprot.org/uniprot/F7C951 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDHX ^@ http://purl.uniprot.org/uniprot/F7F2T0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/13616:MAL2 ^@ http://purl.uniprot.org/uniprot/F7D7E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RXRG ^@ http://purl.uniprot.org/uniprot/F7C094 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/13616:ACAT2 ^@ http://purl.uniprot.org/uniprot/F6RDB9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/13616:HSD17B7 ^@ http://purl.uniprot.org/uniprot/F7GHF2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily. http://togogenome.org/gene/13616:OLFML1 ^@ http://purl.uniprot.org/uniprot/F7FER2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100024002 ^@ http://purl.uniprot.org/uniprot/F7GDY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HR ^@ http://purl.uniprot.org/uniprot/F6S005 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BMP4 ^@ http://purl.uniprot.org/uniprot/F7DWN3 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:LOC100009897 ^@ http://purl.uniprot.org/uniprot/F6PJJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GOLM1 ^@ http://purl.uniprot.org/uniprot/F7ELM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/13616:LOC100011471 ^@ http://purl.uniprot.org/uniprot/F7C8C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/13616:CSTF2 ^@ http://purl.uniprot.org/uniprot/F6QNJ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC9A8 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8F0|||http://purl.uniprot.org/uniprot/F7A690 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/13616:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGE5|||http://purl.uniprot.org/uniprot/A0A5F8HA64 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/13616:HMGN1 ^@ http://purl.uniprot.org/uniprot/F6S609 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/13616:LOC100028276 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB30 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:VRTN ^@ http://purl.uniprot.org/uniprot/F7AG57 ^@ Similarity ^@ Belongs to the vertnin family. http://togogenome.org/gene/13616:SEPT11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLI5|||http://purl.uniprot.org/uniprot/F7GM08 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/13616:DNAJC22 ^@ http://purl.uniprot.org/uniprot/F6Y900 ^@ Function|||Subcellular Location Annotation ^@ May function as a co-chaperone.|||Membrane http://togogenome.org/gene/13616:AK3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGD5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/13616:SUCLG1 ^@ http://purl.uniprot.org/uniprot/F6WVM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit. Different beta subunits determine nucleotide specificity. Together with the ATP-specific beta subunit SUCLA2, forms an ADP-forming succinyl-CoA synthetase (A-SCS). Together with the GTP-specific beta subunit SUCLG2 forms a GDP-forming succinyl-CoA synthetase (G-SCS).|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and specificity for either ATP or GTP is provided by different beta subunits. http://togogenome.org/gene/13616:ATF7IP ^@ http://purl.uniprot.org/uniprot/F7B6U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/13616:CDKN1B ^@ http://purl.uniprot.org/uniprot/F6PGI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/13616:CTPS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAF2|||http://purl.uniprot.org/uniprot/F6XYN7|||http://purl.uniprot.org/uniprot/K7E4X2 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/13616:ADAM12 ^@ http://purl.uniprot.org/uniprot/F6ZF10 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:HUS1 ^@ http://purl.uniprot.org/uniprot/F7AYQ2 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/13616:NFRKB ^@ http://purl.uniprot.org/uniprot/F7FX68 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLITRK6 ^@ http://purl.uniprot.org/uniprot/F6R8M5 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:LOC103093750 ^@ http://purl.uniprot.org/uniprot/F7C584 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CEBPB ^@ http://purl.uniprot.org/uniprot/F7A5L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/13616:NPL ^@ http://purl.uniprot.org/uniprot/A0A5F8H8K2|||http://purl.uniprot.org/uniprot/F6PUU9 ^@ Similarity|||Subunit ^@ Belongs to the DapA family.|||Homotetramer. http://togogenome.org/gene/13616:XIRP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTW9 ^@ Domain|||Function|||Similarity ^@ Belongs to the Xin family.|||Protects actin filaments from depolymerization.|||Xin repeats bind F-actin. http://togogenome.org/gene/13616:LOC100026637 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:KIF25 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1C2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:PACS2 ^@ http://purl.uniprot.org/uniprot/F7E808 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/13616:FNIP2 ^@ http://purl.uniprot.org/uniprot/F6V094 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:FIS1 ^@ http://purl.uniprot.org/uniprot/F7E999 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Involved in the fragmentation of the mitochondrial network and its perinuclear clustering.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/13616:RBCK1 ^@ http://purl.uniprot.org/uniprot/F6VDA7 ^@ Similarity ^@ Belongs to the RBR family. http://togogenome.org/gene/13616:LOC100022920 ^@ http://purl.uniprot.org/uniprot/F6YEC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/13616:SEMA3G ^@ http://purl.uniprot.org/uniprot/F6VJZ6 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:BZW1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPI7 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/13616:AMZ1 ^@ http://purl.uniprot.org/uniprot/F6TG05 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/13616:FBXO25 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH52|||http://purl.uniprot.org/uniprot/A0A5F8HHB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TAF12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBI8|||http://purl.uniprot.org/uniprot/A0A5F8HHB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/13616:LGI1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H271|||http://purl.uniprot.org/uniprot/F6XG60 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:LOC100015642 ^@ http://purl.uniprot.org/uniprot/M9MMH7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:NARF ^@ http://purl.uniprot.org/uniprot/F6RZA8 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/13616:FOXF2 ^@ http://purl.uniprot.org/uniprot/F7FGY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BTF3L4 ^@ http://purl.uniprot.org/uniprot/F6SSU1 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/13616:AP2S1 ^@ http://purl.uniprot.org/uniprot/F7FQU7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/13616:PLCG2 ^@ http://purl.uniprot.org/uniprot/F7BVQ1 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/13616:SAMHD1 ^@ http://purl.uniprot.org/uniprot/F7CIF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAMHD1 family.|||Chromosome http://togogenome.org/gene/13616:THRB ^@ http://purl.uniprot.org/uniprot/A0A5F8G8X0|||http://purl.uniprot.org/uniprot/A0A5F8GH58|||http://purl.uniprot.org/uniprot/F7G6F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:MSX1 ^@ http://purl.uniprot.org/uniprot/F7EMU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ANXA5 ^@ http://purl.uniprot.org/uniprot/F7GJP3 ^@ Domain|||Function|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||This protein is an anticoagulant protein that acts as an indirect inhibitor of the thromboplastin-specific complex, which is involved in the blood coagulation cascade. http://togogenome.org/gene/13616:TMEM230 ^@ http://purl.uniprot.org/uniprot/F6YEP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/13616:TMCC3 ^@ http://purl.uniprot.org/uniprot/F7FTZ9 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/13616:KIF5C ^@ http://purl.uniprot.org/uniprot/F7GBT8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:TMED5 ^@ http://purl.uniprot.org/uniprot/F7C2E4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Interacts with TMED9 and TMED10.|||Membrane|||Potential role in vesicular protein trafficking, mainly in the early secretory pathway. Required for the maintenance of the Golgi apparatus; involved in protein exchange between Golgi stacks during assembly. Probably not required for COPI-vesicle-mediated retrograde transport.|||cis-Golgi network membrane http://togogenome.org/gene/13616:RBBP7 ^@ http://purl.uniprot.org/uniprot/F6QE05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CNNM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKR4|||http://purl.uniprot.org/uniprot/A0A5F8H6Z0|||http://purl.uniprot.org/uniprot/F6ZZU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Membrane http://togogenome.org/gene/13616:EPHA8 ^@ http://purl.uniprot.org/uniprot/F7EB26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100016987 ^@ http://purl.uniprot.org/uniprot/F6RWK2 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:FAM168B ^@ http://purl.uniprot.org/uniprot/F7B2L4 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/13616:LOC103106765 ^@ http://purl.uniprot.org/uniprot/K7E3N5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:POU4F3 ^@ http://purl.uniprot.org/uniprot/F6WMZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/13616:ZDHHC1 ^@ http://purl.uniprot.org/uniprot/F6WW01 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:LOC100017379 ^@ http://purl.uniprot.org/uniprot/F7DFY5 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/13616:LOC100026332 ^@ http://purl.uniprot.org/uniprot/F7GDK6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUZ2|||http://purl.uniprot.org/uniprot/A0A5F8H314|||http://purl.uniprot.org/uniprot/F6SEA3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:GSR ^@ http://purl.uniprot.org/uniprot/F7CP75 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol. http://togogenome.org/gene/13616:MYO5B ^@ http://purl.uniprot.org/uniprot/A0A5F8GP95|||http://purl.uniprot.org/uniprot/F7DUZ7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:MSRA ^@ http://purl.uniprot.org/uniprot/A0A5F8G7S7 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/13616:RTBDN ^@ http://purl.uniprot.org/uniprot/K7E4M5 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/13616:NOP14 ^@ http://purl.uniprot.org/uniprot/F7EDB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/13616:TREH ^@ http://purl.uniprot.org/uniprot/F7D8S1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/13616:TRAPPC1 ^@ http://purl.uniprot.org/uniprot/F7G005 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/13616:SLC2A1 ^@ http://purl.uniprot.org/uniprot/F6TLZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/13616:COLGALT1 ^@ http://purl.uniprot.org/uniprot/F6W8D5 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/13616:MRPL22 ^@ http://purl.uniprot.org/uniprot/F7CXK5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/13616:SLC30A7 ^@ http://purl.uniprot.org/uniprot/F7DX04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Functions as a zinc transporter.|||Homooligomer.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/13616:C1H16orf70 ^@ http://purl.uniprot.org/uniprot/F7AGW7 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/13616:EMC3 ^@ http://purl.uniprot.org/uniprot/F6YL58 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/13616:C6 ^@ http://purl.uniprot.org/uniprot/F7BFY4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:NFKB1 ^@ http://purl.uniprot.org/uniprot/F7DLB9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:NDUFB7 ^@ http://purl.uniprot.org/uniprot/F7G4X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/13616:SLC30A10 ^@ http://purl.uniprot.org/uniprot/F6X6S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/13616:AKAP8 ^@ http://purl.uniprot.org/uniprot/F7ASS2 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/13616:VGLL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL17|||http://purl.uniprot.org/uniprot/F6ZY15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/13616:LOC100012973 ^@ http://purl.uniprot.org/uniprot/F6WQN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RAMP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G309|||http://purl.uniprot.org/uniprot/F6W6P3 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/13616:PRM1 ^@ http://purl.uniprot.org/uniprot/P67836 ^@ Function|||Similarity|||Subcellular Location Annotation|||Tissue Specificity ^@ Belongs to the protamine P1 family.|||Chromosome|||Nucleus|||Protamines substitute for histones in the chromatin of sperm during the haploid phase of spermatogenesis. They compact sperm DNA into a highly condensed, stable and inactive complex.|||Testis. http://togogenome.org/gene/13616:PPP1R14D ^@ http://purl.uniprot.org/uniprot/F6SZL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP1 inhibitor family.|||Cytoplasm|||Inhibitor of PPP1CA. http://togogenome.org/gene/13616:LOC100021695 ^@ http://purl.uniprot.org/uniprot/F7FDA3 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.|||Homotetramer. http://togogenome.org/gene/13616:GLB1L ^@ http://purl.uniprot.org/uniprot/A0A5F8GCM0|||http://purl.uniprot.org/uniprot/F6TM00 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/13616:NUP210 ^@ http://purl.uniprot.org/uniprot/F6PHA8 ^@ Similarity ^@ Belongs to the NUP210 family. http://togogenome.org/gene/13616:TMEM14C ^@ http://purl.uniprot.org/uniprot/F6XWW6 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/13616:AP4E1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H008 ^@ Function|||Similarity|||Subunit ^@ Adaptor protein complex 4 (AP-4) is a heterotetramer composed of two large adaptins, a medium adaptin and a small adaptin.|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 4 (AP-4). Adaptor protein complexes are vesicle coat components involved both in vesicle formation and cargo selection. They control the vesicular transport of proteins in different trafficking pathways. AP-4 forms a non clathrin-associated coat on vesicles departing the trans-Golgi network (TGN) and may be involved in the targeting of proteins from the trans-Golgi network (TGN) to the endosomal-lysosomal system. http://togogenome.org/gene/13616:TUBA8 ^@ http://purl.uniprot.org/uniprot/F7CAU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/13616:SLC35F2 ^@ http://purl.uniprot.org/uniprot/F7E7K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/13616:PRND ^@ http://purl.uniprot.org/uniprot/A2BDH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TFF2 ^@ http://purl.uniprot.org/uniprot/F6QZC5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TMEM134 ^@ http://purl.uniprot.org/uniprot/F6WJI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Membrane http://togogenome.org/gene/13616:ADAT2 ^@ http://purl.uniprot.org/uniprot/F6T4D9 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. ADAT2 subfamily.|||Probably participates in deamination of adenosine-34 to inosine in many tRNAs. http://togogenome.org/gene/13616:GAP43 ^@ http://purl.uniprot.org/uniprot/F7BTK7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Cell membrane|||Cytoplasm|||Identified in a complex containing FGFR4, NCAM1, CDH2, PLCG1, FRS2, SRC, SHC1, GAP43 and CTTN. Interacts (via IQ domain) with calmodulin. Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Perikaryon|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||axon|||dendrite|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/13616:NOL11 ^@ http://purl.uniprot.org/uniprot/F7FYT0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4Z3|||http://purl.uniprot.org/uniprot/A0A5F8HE63 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/13616:LOC100011049 ^@ http://purl.uniprot.org/uniprot/F6YRT9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RXRB ^@ http://purl.uniprot.org/uniprot/A0A5F8H805 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/13616:CAV1 ^@ http://purl.uniprot.org/uniprot/F7FDW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/13616:UBA52 ^@ http://purl.uniprot.org/uniprot/F7CRY4 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/13616:LIAS ^@ http://purl.uniprot.org/uniprot/F7AQ30 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/13616:LOC100019025 ^@ http://purl.uniprot.org/uniprot/F6V6K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GSTZ1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAS3|||http://purl.uniprot.org/uniprot/F7D0R6 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/13616:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A5F8GDJ4|||http://purl.uniprot.org/uniprot/F7F3V5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/13616:NPNT ^@ http://purl.uniprot.org/uniprot/A0A5F8H0E4|||http://purl.uniprot.org/uniprot/A0A5F8H223|||http://purl.uniprot.org/uniprot/F6ZAS9 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:DHX15 ^@ http://purl.uniprot.org/uniprot/F6Y5H8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/13616:HEATR1 ^@ http://purl.uniprot.org/uniprot/F7G8Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HEATR1/UTP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/13616:NINJ1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/13616:LOC103105715 ^@ http://purl.uniprot.org/uniprot/K7E3B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:RPS3 ^@ http://purl.uniprot.org/uniprot/F6RG35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Membrane|||Mitochondrion inner membrane|||nucleolus|||spindle http://togogenome.org/gene/13616:C4H1orf174 ^@ http://purl.uniprot.org/uniprot/F7F2Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0688 family.|||Nucleus http://togogenome.org/gene/13616:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A5F8H303 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/13616:PELI1 ^@ http://purl.uniprot.org/uniprot/F6TZ95 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/13616:MYOZ2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPB1 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/13616:FAM76B ^@ http://purl.uniprot.org/uniprot/A0A5F8G5E9|||http://purl.uniprot.org/uniprot/A0A5F8G6B2 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/13616:LOC100015860 ^@ http://purl.uniprot.org/uniprot/F7G1Y8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/13616:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A5F8HH95|||http://purl.uniprot.org/uniprot/F7DPN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:KIF20B ^@ http://purl.uniprot.org/uniprot/F6SHK6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:KCNJ13 ^@ http://purl.uniprot.org/uniprot/F6YR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/13616:BAP1 ^@ http://purl.uniprot.org/uniprot/F6RI15 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/13616:SGMS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/13616:PROK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H910 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/13616:BATF ^@ http://purl.uniprot.org/uniprot/F6XD41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Cytoplasm http://togogenome.org/gene/13616:MAL ^@ http://purl.uniprot.org/uniprot/A0A5F8G6T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/F7G4G9 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100024719 ^@ http://purl.uniprot.org/uniprot/A0A5F8HA08 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:SLC12A9 ^@ http://purl.uniprot.org/uniprot/F6V5G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R598 ^@ http://purl.uniprot.org/uniprot/F7FK66 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:EPT1 ^@ http://purl.uniprot.org/uniprot/F7FRZ9 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/13616:DUSP2 ^@ http://purl.uniprot.org/uniprot/F6YIH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/13616:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:GTF2F2 ^@ http://purl.uniprot.org/uniprot/F6QZ41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. http://togogenome.org/gene/13616:PAX3 ^@ http://purl.uniprot.org/uniprot/F6XVW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/13616:FAM208B ^@ http://purl.uniprot.org/uniprot/F7B3T1 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/13616:B3GNT3 ^@ http://purl.uniprot.org/uniprot/F7BK30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100017621 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGA4|||http://purl.uniprot.org/uniprot/A0A5F8GQJ6|||http://purl.uniprot.org/uniprot/F6X7K6 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/13616:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/F6XUY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:POLH ^@ http://purl.uniprot.org/uniprot/F7G0E4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TPRG1 ^@ http://purl.uniprot.org/uniprot/F7FUV1 ^@ Similarity ^@ Belongs to the TPRG1 family. http://togogenome.org/gene/13616:LOC100028578 ^@ http://purl.uniprot.org/uniprot/F7EBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MEIS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H950|||http://purl.uniprot.org/uniprot/F7CIR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/13616:HNMT ^@ http://purl.uniprot.org/uniprot/A0A5F8H7S0 ^@ Function|||Subunit ^@ Inactivates histamine by N-methylation. Plays an important role in degrading histamine and in regulating the airway response to histamine.|||Monomer. http://togogenome.org/gene/13616:NR1D2 ^@ http://purl.uniprot.org/uniprot/F7GGA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:SYT1 ^@ http://purl.uniprot.org/uniprot/F7FJ84 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:LOC100011820 ^@ http://purl.uniprot.org/uniprot/K7E1T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:DLST ^@ http://purl.uniprot.org/uniprot/F7E1R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/13616:LOC100016082 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE86 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/13616:HDAC5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB78|||http://purl.uniprot.org/uniprot/F7G734 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/13616:MRPL41 ^@ http://purl.uniprot.org/uniprot/F6SEJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/13616:PISD ^@ http://purl.uniprot.org/uniprot/F6TFC0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:TRAM2 ^@ http://purl.uniprot.org/uniprot/F6YZB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/13616:MTIF3 ^@ http://purl.uniprot.org/uniprot/F7G2D6 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/13616:SARM1 ^@ http://purl.uniprot.org/uniprot/F6QTG2 ^@ Similarity ^@ Belongs to the SARM1 family. http://togogenome.org/gene/13616:GPR37L1 ^@ http://purl.uniprot.org/uniprot/F6X490 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TRAF6 ^@ http://purl.uniprot.org/uniprot/F6SAI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family. A subfamily.|||Lipid droplet|||Nucleus|||cell cortex http://togogenome.org/gene/13616:DDX31 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ27 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:PANX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/13616:OVOL2 ^@ http://purl.uniprot.org/uniprot/F7GFR3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100031088 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ73 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/13616:DOK4 ^@ http://purl.uniprot.org/uniprot/F7C3J4 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/13616:S100A10 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK80 ^@ Function ^@ Because S100A10 induces the dimerization of ANXA2/p36, it may function as a regulator of protein phosphorylation in that the ANXA2 monomer is the preferred target (in vitro) of tyrosine-specific kinase. http://togogenome.org/gene/13616:LOC100017002 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DACT2 ^@ http://purl.uniprot.org/uniprot/F6TV63 ^@ Similarity ^@ Belongs to the dapper family. http://togogenome.org/gene/13616:EDN1 ^@ http://purl.uniprot.org/uniprot/F6YR31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/13616:LOC100019741 ^@ http://purl.uniprot.org/uniprot/F7FVN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:ANXA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2F7|||http://purl.uniprot.org/uniprot/F6S7A7 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/13616:RPL3 ^@ http://purl.uniprot.org/uniprot/F7C419 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/13616:LOC103102651 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ48 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/13616:LOC100023334 ^@ http://purl.uniprot.org/uniprot/F6Q121 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100024846 ^@ http://purl.uniprot.org/uniprot/F7GIH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100616991 ^@ http://purl.uniprot.org/uniprot/F7D5M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DSE ^@ http://purl.uniprot.org/uniprot/F6Z8C6 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/13616:VPS45 ^@ http://purl.uniprot.org/uniprot/F7AE31 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/13616:DUSP26 ^@ http://purl.uniprot.org/uniprot/F7EMZ0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:RTCA ^@ http://purl.uniprot.org/uniprot/F7GBC6 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/13616:TIMM23B ^@ http://purl.uniprot.org/uniprot/F7DI36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:CA8 ^@ http://purl.uniprot.org/uniprot/F7CX54 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/13616:PRR15L ^@ http://purl.uniprot.org/uniprot/F7FVM6 ^@ Similarity ^@ Belongs to the PRR15 family. http://togogenome.org/gene/13616:ASZ1 ^@ http://purl.uniprot.org/uniprot/F6Z443 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with DDX4, PIWIL1, RANBP9 and TDRD1. http://togogenome.org/gene/13616:GRINA ^@ http://purl.uniprot.org/uniprot/F7A787 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:AGL ^@ http://purl.uniprot.org/uniprot/F7GJD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/13616:TCTEX1D4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFR1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/13616:VN2R615 ^@ http://purl.uniprot.org/uniprot/F7DRE2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SCG2 ^@ http://purl.uniprot.org/uniprot/F7FCM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chromogranin/secretogranin protein family.|||Interacts with Secretogranin III/SCG3.|||Neuroendocrine protein of the granin family that regulates the biogenesis of secretory granules.|||Secreted http://togogenome.org/gene/13616:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH75|||http://purl.uniprot.org/uniprot/F6WGG1 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/13616:T2R22 ^@ http://purl.uniprot.org/uniprot/Q2AB97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:PANK4 ^@ http://purl.uniprot.org/uniprot/F7DJ58 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activity is strongly promoted by Co(2+), Ni(2+), Mg(2+) and Mn(2+). Activity is inhibited by EDTA.|||Belongs to the type II pantothenate kinase family.|||Cytoplasm|||Homodimer. Interacts with PKM.|||In the N-terminal section; belongs to the type II pantothenate kinase family.|||Phosphatase which shows a preference for 4'-phosphopantetheine and its oxidatively damaged forms (sulfonate or S-sulfonate), providing strong indirect evidence that the phosphatase activity pre-empts damage in the coenzyme A (CoA) pathway. Hydrolyzing excess 4'-phosphopantetheine could constitute a directed overflow mechanism to prevent its oxidation to the S-sulfonate, sulfonate, or other forms. Hydrolyzing 4'-phosphopantetheine sulfonate or S-sulfonate would forestall their conversion to inactive forms of CoA and acyl carrier protein. May play a role in the physiological regulation of CoA intracellular levels. http://togogenome.org/gene/13616:EEF1B2 ^@ http://purl.uniprot.org/uniprot/F7EG66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/13616:NME2 ^@ http://purl.uniprot.org/uniprot/F6PJ02 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/13616:DST ^@ http://purl.uniprot.org/uniprot/A0A5F8GK48 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:NDE1 ^@ http://purl.uniprot.org/uniprot/F6SVX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||kinetochore|||spindle http://togogenome.org/gene/13616:LYG2 ^@ http://purl.uniprot.org/uniprot/F7FWC5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/13616:COPB1 ^@ http://purl.uniprot.org/uniprot/F7EEU7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/13616:DRC1 ^@ http://purl.uniprot.org/uniprot/F7FS23 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DRC1 family.|||Component of the nexin-dynein regulatory complex (N-DRC).|||cilium axoneme|||flagellum axoneme http://togogenome.org/gene/13616:VN2R533 ^@ http://purl.uniprot.org/uniprot/F6W3N1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ADGRE5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G271|||http://purl.uniprot.org/uniprot/A0A5F8HIY9|||http://purl.uniprot.org/uniprot/F7E0D4 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:CRYBA1 ^@ http://purl.uniprot.org/uniprot/F6XTA6 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/13616:TMEM251 ^@ http://purl.uniprot.org/uniprot/F7G3F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM251 family.|||Membrane http://togogenome.org/gene/13616:MTG2 ^@ http://purl.uniprot.org/uniprot/F7D2H5 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/13616:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100028079 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDN2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:RAX ^@ http://purl.uniprot.org/uniprot/F7ARM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/13616:B4GALT4 ^@ http://purl.uniprot.org/uniprot/F7B788 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:GAST ^@ http://purl.uniprot.org/uniprot/F7EQ14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Gastrin stimulates the stomach mucosa to produce and secrete hydrochloric acid and the pancreas to secrete its digestive enzymes. It also stimulates smooth muscle contraction and increases blood circulation and water secretion in the stomach and intestine.|||Secreted http://togogenome.org/gene/13616:LOC100028402 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PDX1 ^@ http://purl.uniprot.org/uniprot/F7BPP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:CNOT6L ^@ http://purl.uniprot.org/uniprot/A0A5F8GLP1|||http://purl.uniprot.org/uniprot/A0A5F8HK95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TIMM21 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY61|||http://purl.uniprot.org/uniprot/A0A5F8HAD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion membrane|||Participates in the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Also required for assembly of mitochondrial respiratory chain complex I and complex IV as component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex. Probably shuttles between the presequence translocase and respiratory-chain assembly intermediates in a process that promotes incorporation of early nuclear-encoded subunits into these complexes. http://togogenome.org/gene/13616:KRT20 ^@ http://purl.uniprot.org/uniprot/F7C2V3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:monDomV1R1207 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ITGA2B ^@ http://purl.uniprot.org/uniprot/F6RI44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/F6UCS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/13616:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3I8|||http://purl.uniprot.org/uniprot/A0A5F8HA60 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/13616:BBS2 ^@ http://purl.uniprot.org/uniprot/F7D8D3 ^@ Subcellular Location Annotation ^@ centriolar satellite|||cilium membrane http://togogenome.org/gene/13616:SLC19A2 ^@ http://purl.uniprot.org/uniprot/F6PLI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Cell membrane|||High-affinity transporter for the intake of thiamine. http://togogenome.org/gene/13616:LOC103102160 ^@ http://purl.uniprot.org/uniprot/F7G1L0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8V4|||http://purl.uniprot.org/uniprot/F7G783 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/13616:SLC9A5 ^@ http://purl.uniprot.org/uniprot/F7AJ68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/13616:MRPL44 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/13616:IRF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKM1|||http://purl.uniprot.org/uniprot/F6VVK5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:MTFMT ^@ http://purl.uniprot.org/uniprot/F7A6V0 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/13616:FERMT1 ^@ http://purl.uniprot.org/uniprot/F6YTW9 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/13616:MAF ^@ http://purl.uniprot.org/uniprot/F7G1L4 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/13616:NEU3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7G2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/13616:CCND2 ^@ http://purl.uniprot.org/uniprot/F6PTI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TMEM208 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||May function as a negative regulator of endoplasmic reticulum-stress induced autophagy.|||Membrane http://togogenome.org/gene/13616:monDomV1R1251 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:C1H15orf65 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKW6 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/13616:LOC100018068 ^@ http://purl.uniprot.org/uniprot/F6QIS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ATP5A1 ^@ http://purl.uniprot.org/uniprot/F6THT5 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/13616:PAM16 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWL2|||http://purl.uniprot.org/uniprot/F7ER96 ^@ Similarity ^@ Belongs to the TIM16/PAM16 family. http://togogenome.org/gene/13616:WASL ^@ http://purl.uniprot.org/uniprot/F6TLC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TNP1 ^@ http://purl.uniprot.org/uniprot/F6ZI63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear transition protein 1 family.|||Nucleus http://togogenome.org/gene/13616:FAM91A1 ^@ http://purl.uniprot.org/uniprot/F6W104 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/13616:ITK ^@ http://purl.uniprot.org/uniprot/F7FTR6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:ARV1 ^@ http://purl.uniprot.org/uniprot/F7GJN8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane http://togogenome.org/gene/13616:MELK ^@ http://purl.uniprot.org/uniprot/F7FWS7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/13616:ARPC5L ^@ http://purl.uniprot.org/uniprot/F6WN64 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development.|||May be a component of the Arp2/3 complex in which it may replace ARPC5.|||May function as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/13616:PTS ^@ http://purl.uniprot.org/uniprot/A0A5F8GKA0 ^@ Function|||Similarity ^@ Belongs to the PTPS family.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/13616:LOC100023867 ^@ http://purl.uniprot.org/uniprot/F7AFL4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:ATP1B2 ^@ http://purl.uniprot.org/uniprot/F7FQX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/13616:IFNK ^@ http://purl.uniprot.org/uniprot/A8E6F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6A3|||http://purl.uniprot.org/uniprot/F6VQ66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:KIAA1324L ^@ http://purl.uniprot.org/uniprot/F6V5K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELAPOR family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TDP1 ^@ http://purl.uniprot.org/uniprot/F6PJT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/13616:LOC107648878 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:STX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG36 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/13616:GJB4 ^@ http://purl.uniprot.org/uniprot/F7E348 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:LOC100020048 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MODO-UI ^@ http://purl.uniprot.org/uniprot/C6ZIV2 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:LOC100618756 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPU1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:C1QA ^@ http://purl.uniprot.org/uniprot/A0A5F8GSF6 ^@ Function ^@ C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. http://togogenome.org/gene/13616:LOC100016035 ^@ http://purl.uniprot.org/uniprot/F7CQE9 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/13616:MAP4K1 ^@ http://purl.uniprot.org/uniprot/F6YWC5 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/13616:SPCS1 ^@ http://purl.uniprot.org/uniprot/F6SRE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CNN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H774 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/13616:GPR17 ^@ http://purl.uniprot.org/uniprot/F6UCF6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:NCSTN ^@ http://purl.uniprot.org/uniprot/F7F9Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nicastrin family.|||Membrane http://togogenome.org/gene/13616:DNA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCX5|||http://purl.uniprot.org/uniprot/F6S4L6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Binds 1 [4Fe-4S] cluster.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/13616:CNKSR2 ^@ http://purl.uniprot.org/uniprot/F7CLK9 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/13616:CCT2 ^@ http://purl.uniprot.org/uniprot/F7F689 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/13616:KIAA0907 ^@ http://purl.uniprot.org/uniprot/F6UL87 ^@ Similarity ^@ Belongs to the KHDC4 family. http://togogenome.org/gene/13616:NR1H4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:IGFBP4 ^@ http://purl.uniprot.org/uniprot/F7ABV3 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Binds IGF2 more than IGF1.|||IGF-binding proteins prolong the half-life of the IGFs and have been shown to either inhibit or stimulate the growth promoting effects of the IGFs on cell culture. They alter the interaction of IGFs with their cell surface receptors.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/F7GHP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:BVES ^@ http://purl.uniprot.org/uniprot/F6ZWG8 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/13616:PSENEN ^@ http://purl.uniprot.org/uniprot/F6VQU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PEN-2 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:CAMLG ^@ http://purl.uniprot.org/uniprot/A0A5F8H8M1 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1/WRB, acts as a membrane receptor for soluble GET3/TRC40, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. Required for the stability of GET1. Stimulates calcium signaling in T cells through its involvement in elevation of intracellular calcium. Essential for the survival of peripheral follicular B cells. http://togogenome.org/gene/13616:PHACTR3 ^@ http://purl.uniprot.org/uniprot/F6ZC64 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/13616:ARSK ^@ http://purl.uniprot.org/uniprot/F7ESB2 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:CHST1 ^@ http://purl.uniprot.org/uniprot/F6Z900 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100013054 ^@ http://purl.uniprot.org/uniprot/F6Z242 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/13616:BRPF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9J0|||http://purl.uniprot.org/uniprot/F6UD32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIK4|||http://purl.uniprot.org/uniprot/F7GFQ3 ^@ Function|||Subunit ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs.|||Interacts with TRMT112. http://togogenome.org/gene/13616:IRX2 ^@ http://purl.uniprot.org/uniprot/F6R2X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/13616:QSOX2 ^@ http://purl.uniprot.org/uniprot/F7E0U9 ^@ Caution|||Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:IMP4 ^@ http://purl.uniprot.org/uniprot/F7GI18 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:LOC100012266 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW64 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:MND1 ^@ http://purl.uniprot.org/uniprot/F7D4R4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMEM200B ^@ http://purl.uniprot.org/uniprot/F7EN37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/13616:TFAP2B ^@ http://purl.uniprot.org/uniprot/F7GKB8 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/13616:LOC100023806 ^@ http://purl.uniprot.org/uniprot/F6ZH23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TM4SF5 ^@ http://purl.uniprot.org/uniprot/F7DJD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/13616:EFNA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2K2|||http://purl.uniprot.org/uniprot/A0A5F8HEI1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:POPDC3 ^@ http://purl.uniprot.org/uniprot/F6ZWH6 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/13616:FIP1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5T5|||http://purl.uniprot.org/uniprot/A0A5F8GF49|||http://purl.uniprot.org/uniprot/F7E5Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/13616:YIF1B ^@ http://purl.uniprot.org/uniprot/F7BM72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/13616:CLDN20 ^@ http://purl.uniprot.org/uniprot/F6SEP6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:GFOD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEG8|||http://purl.uniprot.org/uniprot/F6VKR9 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/13616:LOC107649021 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFL8 ^@ Function ^@ The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution. http://togogenome.org/gene/13616:AMOTL2 ^@ http://purl.uniprot.org/uniprot/F7B3K2 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/13616:PEX10 ^@ http://purl.uniprot.org/uniprot/F7ELT0 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/13616:LOC100618293 ^@ http://purl.uniprot.org/uniprot/F7BAF0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/13616:MTMR9 ^@ http://purl.uniprot.org/uniprot/F7GCP6 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/13616:TNFSF12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKJ9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/13616:SLC6A7 ^@ http://purl.uniprot.org/uniprot/F6XTS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:LONP1 ^@ http://purl.uniprot.org/uniprot/F7BZI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial promoters and RNA in a single-stranded, site-specific, and strand-specific manner. May regulate mitochondrial DNA replication and/or gene expression using site-specific, single-stranded DNA binding to target the degradation of regulatory proteins binding to adjacent sites in mitochondrial promoters.|||Belongs to the peptidase S16 family.|||Homohexamer. Organized in a ring with a central cavity. The ATP-binding and proteolytic domains (AP-domain) form a hexameric chamber, while the N-terminal domain is arranged as a trimer of dimers. DNA and RNA binding is stimulated by substrate and inhibited by ATP binding. Interacts with TWNK and mitochondrial DNA polymerase subunit POLG.|||Mitochondrion matrix http://togogenome.org/gene/13616:ADGRG6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVE8|||http://purl.uniprot.org/uniprot/A0A5F8HJH7|||http://purl.uniprot.org/uniprot/F6VSG8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:HOPX ^@ http://purl.uniprot.org/uniprot/A0A5F8GHL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GLB1L2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6U6|||http://purl.uniprot.org/uniprot/F7F3M1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/13616:LOC100026503 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFZ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/13616:FAM122B ^@ http://purl.uniprot.org/uniprot/A0A5F8G6Z8|||http://purl.uniprot.org/uniprot/F7BVR8 ^@ Similarity ^@ Belongs to the FAM122 family. http://togogenome.org/gene/13616:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/F7BIR5 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/13616:PFDN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H854 ^@ Function|||Similarity ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins. http://togogenome.org/gene/13616:SERP1 ^@ http://purl.uniprot.org/uniprot/F6T2I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation.|||Membrane http://togogenome.org/gene/13616:TMOD2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAC4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:ELOF1 ^@ http://purl.uniprot.org/uniprot/F7F290 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/13616:XKRX ^@ http://purl.uniprot.org/uniprot/F7CWH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/13616:METTL3 ^@ http://purl.uniprot.org/uniprot/F7FEI2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/13616:SCD ^@ http://purl.uniprot.org/uniprot/F7D550 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/13616:ADRB2 ^@ http://purl.uniprot.org/uniprot/F7BW45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRB2 sub-subfamily.|||Beta-adrenergic receptors mediate the catecholamine-induced activation of adenylate cyclase through the action of G proteins. The beta-2-adrenergic receptor binds epinephrine with an approximately 30-fold greater affinity than it does norepinephrine.|||Cell membrane|||Early endosome|||Golgi apparatus|||Membrane http://togogenome.org/gene/13616:PPP1R12B ^@ http://purl.uniprot.org/uniprot/A0A5F8HE46|||http://purl.uniprot.org/uniprot/F6SBH5 ^@ Subcellular Location Annotation|||Subunit ^@ PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits.|||stress fiber http://togogenome.org/gene/13616:ENTPD7 ^@ http://purl.uniprot.org/uniprot/F7C8K3 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G831|||http://purl.uniprot.org/uniprot/A0A5F8GXK5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Nucleus|||Synapse http://togogenome.org/gene/13616:FARSB ^@ http://purl.uniprot.org/uniprot/F6XVT6 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/13616:IL17D ^@ http://purl.uniprot.org/uniprot/F7DJ22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/13616:HEXIM1 ^@ http://purl.uniprot.org/uniprot/F7E876 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HEXIM family.|||Nucleus http://togogenome.org/gene/13616:TMA16 ^@ http://purl.uniprot.org/uniprot/F7GEJ0 ^@ Function|||Similarity|||Subunit ^@ Associates with pre-60S ribosomal particles.|||Belongs to the TMA16 family.|||Involved in the biogenesis of the 60S ribosomal subunit in the nucleus. http://togogenome.org/gene/13616:LCA5L ^@ http://purl.uniprot.org/uniprot/A0A5F8GEC4|||http://purl.uniprot.org/uniprot/F6S6N9 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/13616:RAP2A ^@ http://purl.uniprot.org/uniprot/A0A5F8G780 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/13616:PMS2 ^@ http://purl.uniprot.org/uniprot/F7E4Y3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/13616:BRF2 ^@ http://purl.uniprot.org/uniprot/F7BZ92 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/13616:PHOSPHO1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIA0|||http://purl.uniprot.org/uniprot/F7CE09 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/13616:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2U3 ^@ Caution|||Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/13616:LOC100030384 ^@ http://purl.uniprot.org/uniprot/F7F1Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103094249 ^@ http://purl.uniprot.org/uniprot/F7FQQ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CDC6 ^@ http://purl.uniprot.org/uniprot/F7BMZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC6/cdc18 family.|||Involved in the initiation of DNA replication. Also participates in checkpoint controls that ensure DNA replication is completed before mitosis is initiated.|||Nucleus http://togogenome.org/gene/13616:TMOD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVB1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:FAM124A ^@ http://purl.uniprot.org/uniprot/F7G7F7 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/13616:NGF ^@ http://purl.uniprot.org/uniprot/F6TNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted http://togogenome.org/gene/13616:ZDHHC21 ^@ http://purl.uniprot.org/uniprot/F7CG33 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:ACTN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G362|||http://purl.uniprot.org/uniprot/F6YXB0 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/13616:NUDT12 ^@ http://purl.uniprot.org/uniprot/F6XSU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Nudix hydrolase family. NudC subfamily.|||Cytoplasmic granule|||Peroxisome http://togogenome.org/gene/13616:SLC9A4 ^@ http://purl.uniprot.org/uniprot/F7EGW4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/13616:DLL1 ^@ http://purl.uniprot.org/uniprot/F7CZU6 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/13616:LOC100012021 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:WASF2 ^@ http://purl.uniprot.org/uniprot/F7FLU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/13616:AJAP1 ^@ http://purl.uniprot.org/uniprot/F7EYW1|||http://purl.uniprot.org/uniprot/K7E2T9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GALNT9 ^@ http://purl.uniprot.org/uniprot/F6XFH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1273 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MAT2A ^@ http://purl.uniprot.org/uniprot/A0A5F8H250 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/13616:HIBCH ^@ http://purl.uniprot.org/uniprot/A0A5F8H1K6|||http://purl.uniprot.org/uniprot/F6QBJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/13616:TBX15 ^@ http://purl.uniprot.org/uniprot/F7D2N6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:C8H7orf55 ^@ http://purl.uniprot.org/uniprot/F6WS80 ^@ Similarity ^@ Belongs to the FMC1 family. http://togogenome.org/gene/13616:SLC25A24 ^@ http://purl.uniprot.org/uniprot/F6YHE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FA2H ^@ http://purl.uniprot.org/uniprot/F6YP85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Catalyzes stereospecific hydroxylation of free fatty acids at the C-2 position to produce (R)-2-hydroxy fatty acids, which are building blocks of sphingolipids and glycosphingolipids common in neural tissue and epidermis. Plays an essential role in the synthesis of galactosphingolipids of the myelin sheath. Responsible for the synthesis of sphingolipids and glycosphingolipids involved in the formation of epidermal lamellar bodies critical for skin permeability barrier. Participates in the synthesis of glycosphingolipids and a fraction of type II wax diesters in sebaceous gland, specifically regulating hair follicle homeostasis. Involved in the synthesis of sphingolipids of plasma membrane rafts, controlling lipid raft mobility and trafficking of raft-associated proteins.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:SRSF4 ^@ http://purl.uniprot.org/uniprot/K7E429 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/13616:PNCK ^@ http://purl.uniprot.org/uniprot/F7DJS8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:TOR1B ^@ http://purl.uniprot.org/uniprot/F6PH52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:TNFSF13B ^@ http://purl.uniprot.org/uniprot/F7ASI1 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/13616:CAPN5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4P6 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/13616:MSTN ^@ http://purl.uniprot.org/uniprot/F6QWE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked. Interacts with WFIKKN2, leading to inhibit its activity. Interacts with FSTL3.|||Secreted http://togogenome.org/gene/13616:TDO2 ^@ http://purl.uniprot.org/uniprot/F6S7Q9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer. Dimer of dimers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCG8|||http://purl.uniprot.org/uniprot/A0A5F8GHW6 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/13616:ING2 ^@ http://purl.uniprot.org/uniprot/F6XRF2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/13616:NRDC ^@ http://purl.uniprot.org/uniprot/A0A5F8GWJ0 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/13616:TOR4A ^@ http://purl.uniprot.org/uniprot/F6WXT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Membrane http://togogenome.org/gene/13616:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/F6SYN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/13616:G6PC3 ^@ http://purl.uniprot.org/uniprot/F7G6N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:FABP7 ^@ http://purl.uniprot.org/uniprot/F7ELF5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:GANAB ^@ http://purl.uniprot.org/uniprot/A0A5F8GFQ7|||http://purl.uniprot.org/uniprot/F7EB75 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/13616:monDomV1R1225 ^@ http://purl.uniprot.org/uniprot/F7BT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100028987 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVG2|||http://purl.uniprot.org/uniprot/F7DGL7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/13616:IL6ST ^@ http://purl.uniprot.org/uniprot/F6VD48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/13616:PRLR ^@ http://purl.uniprot.org/uniprot/F7F6E0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Interacts with SMARCA1. Interacts with NEK3 and VAV2 and this interaction is prolactin-dependent.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/13616:AMFR ^@ http://purl.uniprot.org/uniprot/A0A5F8GEK6|||http://purl.uniprot.org/uniprot/F7DTS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:VN2R543 ^@ http://purl.uniprot.org/uniprot/F7EKZ9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100617961 ^@ http://purl.uniprot.org/uniprot/F7BCQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:ARHGDIG ^@ http://purl.uniprot.org/uniprot/F7G770 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/13616:RPL6 ^@ http://purl.uniprot.org/uniprot/F6PIV8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/13616:SDC2 ^@ http://purl.uniprot.org/uniprot/F6PWB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/13616:VMA21 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the V0 complex of the vacuolar ATPase (V-ATPase).|||Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/13616:KCNG1 ^@ http://purl.uniprot.org/uniprot/F7F6U0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SNRNP27 ^@ http://purl.uniprot.org/uniprot/F6S5R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/13616:CLDN14 ^@ http://purl.uniprot.org/uniprot/F6Z9T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:SLC34A1 ^@ http://purl.uniprot.org/uniprot/F6VRE2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ANP32B ^@ http://purl.uniprot.org/uniprot/F6T049 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/13616:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIU6|||http://purl.uniprot.org/uniprot/F6Z1A1 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/13616:TMEM116 ^@ http://purl.uniprot.org/uniprot/F7E2L0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100015895 ^@ http://purl.uniprot.org/uniprot/F7F9P8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/13616:MAPK4 ^@ http://purl.uniprot.org/uniprot/F6YVG7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/13616:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/F7ESF8 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/13616:C5H4orf27 ^@ http://purl.uniprot.org/uniprot/A0A5F8H686|||http://purl.uniprot.org/uniprot/F6Q138 ^@ Similarity ^@ Belongs to the HPF1 family. http://togogenome.org/gene/13616:POLL ^@ http://purl.uniprot.org/uniprot/A0A5F8H1U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/13616:USP20 ^@ http://purl.uniprot.org/uniprot/F6PSB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||centrosome|||perinuclear region http://togogenome.org/gene/13616:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/F6ST88 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:ACTC1 ^@ http://purl.uniprot.org/uniprot/F7GL73 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:LOC100618857 ^@ http://purl.uniprot.org/uniprot/F6YMF4 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:FAM65C ^@ http://purl.uniprot.org/uniprot/A0A5F8HHW7|||http://purl.uniprot.org/uniprot/F7FKL6 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/13616:KEG11_p09 ^@ http://purl.uniprot.org/uniprot/Q65CI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion membrane http://togogenome.org/gene/13616:PITHD1 ^@ http://purl.uniprot.org/uniprot/F7D6T5 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/13616:ISOC1 ^@ http://purl.uniprot.org/uniprot/F7F185 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/13616:VN2R639 ^@ http://purl.uniprot.org/uniprot/A0A5F8H235 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TGFA ^@ http://purl.uniprot.org/uniprot/F6QBL8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MLF2 ^@ http://purl.uniprot.org/uniprot/F7FF99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/13616:MFAP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MFAP family.|||extracellular matrix http://togogenome.org/gene/13616:LOC100013532 ^@ http://purl.uniprot.org/uniprot/F6YPU1 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:monDomV1R1246 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RABGGTA ^@ http://purl.uniprot.org/uniprot/F6WVF8 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of Rab proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX, such as RAB1A, RAB3A, RAB5A and RAB7A. http://togogenome.org/gene/13616:ALDOC ^@ http://purl.uniprot.org/uniprot/F6Q8Q1 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/13616:LOC100018060 ^@ http://purl.uniprot.org/uniprot/F6V845 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:INO80D ^@ http://purl.uniprot.org/uniprot/A0A5F8HGM7|||http://purl.uniprot.org/uniprot/F6ZHX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UCN ^@ http://purl.uniprot.org/uniprot/F7AVH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/13616:STK40 ^@ http://purl.uniprot.org/uniprot/F6ZXC1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/13616:SH3PXD2A ^@ http://purl.uniprot.org/uniprot/A0A5F8HGP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm|||podosome http://togogenome.org/gene/13616:LOC100017021 ^@ http://purl.uniprot.org/uniprot/F7GKU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EML3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5B7 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/13616:POLR2D ^@ http://purl.uniprot.org/uniprot/F7B1V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/13616:C6H16orf58 ^@ http://purl.uniprot.org/uniprot/F7A2S4 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/13616:NDUFS2 ^@ http://purl.uniprot.org/uniprot/F7EQ50 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/13616:BMP3 ^@ http://purl.uniprot.org/uniprot/F6YKG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer.|||Secreted http://togogenome.org/gene/13616:EIF4EBP2 ^@ http://purl.uniprot.org/uniprot/F7CYK5 ^@ Similarity ^@ Belongs to the eIF4E-binding protein family. http://togogenome.org/gene/13616:LOC100030871 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQH4|||http://purl.uniprot.org/uniprot/A0A5F8GRM0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:CWF19L2 ^@ http://purl.uniprot.org/uniprot/F7DN63 ^@ Similarity ^@ Belongs to the CWF19 family. http://togogenome.org/gene/13616:LOC100619033 ^@ http://purl.uniprot.org/uniprot/F7ENP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/13616:LOC100013669 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBB1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:RNF182 ^@ http://purl.uniprot.org/uniprot/F6Q9S1 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/13616:CAPRIN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6E4 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/13616:LOC100014394 ^@ http://purl.uniprot.org/uniprot/F7CQT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:LOC100619044 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF59 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:ATG4B ^@ http://purl.uniprot.org/uniprot/A0A5F8GW90|||http://purl.uniprot.org/uniprot/F6PG58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Endoplasmic reticulum|||Mitochondrion|||autophagosome|||cytosol http://togogenome.org/gene/13616:IL6 ^@ http://purl.uniprot.org/uniprot/F7CIZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/13616:DCST2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX29|||http://purl.uniprot.org/uniprot/F6U3F5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MAS1 ^@ http://purl.uniprot.org/uniprot/F6ZNI5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100028620 ^@ http://purl.uniprot.org/uniprot/F7FSV0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:RBP4 ^@ http://purl.uniprot.org/uniprot/K7E0U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Interacts with TTR.|||Retinol-binding protein that mediates retinol transport in blood plasma.|||Secreted http://togogenome.org/gene/13616:EIF5A ^@ http://purl.uniprot.org/uniprot/F7G3Z4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/13616:SASS6 ^@ http://purl.uniprot.org/uniprot/F7FAN2 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/13616:PEX3 ^@ http://purl.uniprot.org/uniprot/F6T4F5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Interacts with PEX19.|||Involved in peroxisome biosynthesis and integrity. Assembles membrane vesicles before the matrix proteins are translocated. As a docking factor for PEX19, is necessary for the import of peroxisomal membrane proteins in the peroxisomes.|||Peroxisome membrane http://togogenome.org/gene/13616:HS3ST5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6D9 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:LOC103094375 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/13616:GBAS ^@ http://purl.uniprot.org/uniprot/F6ZWX7 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/13616:LOC107650288 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF64 ^@ Similarity ^@ Belongs to the beta type-B retroviral polymerase family. HERV class-II K(HML-2) pol subfamily. http://togogenome.org/gene/13616:STRA6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GED7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:MAN2B2 ^@ http://purl.uniprot.org/uniprot/F7B602 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:DCP2 ^@ http://purl.uniprot.org/uniprot/F7FEL1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/13616:RPS27L ^@ http://purl.uniprot.org/uniprot/A0A5F8H0P7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:monDomV1R1229 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100019436 ^@ http://purl.uniprot.org/uniprot/F6VFE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100025543 ^@ http://purl.uniprot.org/uniprot/F7CGC3 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse|||axon|||dendrite http://togogenome.org/gene/13616:EFNA1 ^@ http://purl.uniprot.org/uniprot/F6UJM9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100020571 ^@ http://purl.uniprot.org/uniprot/K7E4Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:TTC27 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEM5 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/13616:LOC100025990 ^@ http://purl.uniprot.org/uniprot/F6ZD60 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/13616:DAZL ^@ http://purl.uniprot.org/uniprot/A0A5F8GPT9|||http://purl.uniprot.org/uniprot/F6ZCR3|||http://purl.uniprot.org/uniprot/K7E074 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:EMC2 ^@ http://purl.uniprot.org/uniprot/F7A6D8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/13616:LOC100032472 ^@ http://purl.uniprot.org/uniprot/F6PGR8 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/13616:ENTPD8 ^@ http://purl.uniprot.org/uniprot/F6WHR6 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:C5AR1 ^@ http://purl.uniprot.org/uniprot/F7CUC2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:UST ^@ http://purl.uniprot.org/uniprot/F6R231 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/13616:XPO5 ^@ http://purl.uniprot.org/uniprot/F7G0D4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:TAGLN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEV2 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/13616:NR4A3 ^@ http://purl.uniprot.org/uniprot/F6VYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:LOC100013494 ^@ http://purl.uniprot.org/uniprot/F6YMC4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC100013319 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEY3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:ABCB6 ^@ http://purl.uniprot.org/uniprot/F6XYD4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/13616:LOC100021887 ^@ http://purl.uniprot.org/uniprot/F7AI56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SNX7 ^@ http://purl.uniprot.org/uniprot/F7DSA7 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:LOC100013604 ^@ http://purl.uniprot.org/uniprot/F6ZDD9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:ATP8B1 ^@ http://purl.uniprot.org/uniprot/F7AQI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:MED29 ^@ http://purl.uniprot.org/uniprot/F7F8U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 29 family.|||Nucleus http://togogenome.org/gene/13616:GHR ^@ http://purl.uniprot.org/uniprot/F7C0F5|||http://purl.uniprot.org/uniprot/Q9N0Y7 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/13616:ORC4 ^@ http://purl.uniprot.org/uniprot/F7DDI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/13616:B4GALT6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIY1|||http://purl.uniprot.org/uniprot/A0A5F8GVZ2|||http://purl.uniprot.org/uniprot/A0A5F8HAP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:HOXA11 ^@ http://purl.uniprot.org/uniprot/F6USH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:LOC100028638 ^@ http://purl.uniprot.org/uniprot/F7FSN0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/13616:TOMM20L ^@ http://purl.uniprot.org/uniprot/F6ZG99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:XRCC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJP0|||http://purl.uniprot.org/uniprot/F6ZI76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/13616:TOMM20 ^@ http://purl.uniprot.org/uniprot/F7GEZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:LYPLA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAE2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/13616:LOC100030294 ^@ http://purl.uniprot.org/uniprot/F7CT20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NOSIP ^@ http://purl.uniprot.org/uniprot/F6UWQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Cytoplasm|||Negatively regulates nitric oxide production by inducing NOS1 and NOS3 translocation to actin cytoskeleton and inhibiting their enzymatic activity.|||Nucleus http://togogenome.org/gene/13616:PHC3 ^@ http://purl.uniprot.org/uniprot/F7FZ58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GABRQ ^@ http://purl.uniprot.org/uniprot/A0A5F8H1S9|||http://purl.uniprot.org/uniprot/F6WX74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:AMH ^@ http://purl.uniprot.org/uniprot/F6TR95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/13616:RPAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIQ0|||http://purl.uniprot.org/uniprot/F7A3A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex. Interacts with transcribing RNA polymerase II phosphorylated on 'Ser-7' on CTD.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/13616:SCARA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCARA5 family.|||Cell membrane|||Ferritin receptor that mediates non-transferrin-dependent delivery of iron. Mediates cellular uptake of ferritin-bound iron by stimulating ferritin endocytosis from the cell surface with consequent iron delivery within the cell. Delivery of iron to cells by ferritin is required for the development of specific cell types, suggesting the existence of cell type-specific mechanisms of iron traffic in organogenesis, which alternatively utilize transferrin or non-transferrin iron delivery pathways. Ferritin mediates iron uptake in capsule cells of the developing kidney. Binds preferrentially ferritin light chain (FTL) compared to heavy chain (FTH1).|||Homotrimer.|||Membrane http://togogenome.org/gene/13616:LOC100026382 ^@ http://purl.uniprot.org/uniprot/F7EED9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/13616:LOC100020628 ^@ http://purl.uniprot.org/uniprot/F6S9M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LRRC8E ^@ http://purl.uniprot.org/uniprot/F7CGX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DGUOK ^@ http://purl.uniprot.org/uniprot/A0A5F8HFH0 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/13616:TUBGCP3 ^@ http://purl.uniprot.org/uniprot/F6UBF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/13616:LOC103098663 ^@ http://purl.uniprot.org/uniprot/F6YSK2 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/13616:LOC100016274 ^@ http://purl.uniprot.org/uniprot/F6Z5B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:AMDHD1 ^@ http://purl.uniprot.org/uniprot/F6Z9Z3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family. http://togogenome.org/gene/13616:HNRNPAB ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ11 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TNKS2 ^@ http://purl.uniprot.org/uniprot/F7CDC2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:NFASC ^@ http://purl.uniprot.org/uniprot/A0A5F8HEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/13616:MIC-like ^@ http://purl.uniprot.org/uniprot/D7URV4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:KIF27 ^@ http://purl.uniprot.org/uniprot/F7FRJ7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:FSCN2 ^@ http://purl.uniprot.org/uniprot/F7DHX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/13616:CHD2 ^@ http://purl.uniprot.org/uniprot/F6ZM50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:UBL4B ^@ http://purl.uniprot.org/uniprot/Q19KS6 ^@ Miscellaneous|||Subcellular Location Annotation ^@ Cytoplasm|||May have arisen from retrotransposition of the X-linked UBL4A gene during mammalian evolution. http://togogenome.org/gene/13616:EPHA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8S7|||http://purl.uniprot.org/uniprot/F7ANR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DDX59 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYP3|||http://purl.uniprot.org/uniprot/A0A5F8HA09|||http://purl.uniprot.org/uniprot/F6ZPD5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/13616:LTBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLL6|||http://purl.uniprot.org/uniprot/F6SLS5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:MAPRE1 ^@ http://purl.uniprot.org/uniprot/F6RY10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||centrosome|||spindle pole http://togogenome.org/gene/13616:SRFBP1 ^@ http://purl.uniprot.org/uniprot/F6QFG0 ^@ Function|||Subunit ^@ Interacts with SRF. Forms complexes with SRF and SRF cofactors ARID2, MYOCD and NKX2-5. Interacts with the N-terminus of SLC2A4.|||May be involved in regulating transcriptional activation of cardiac genes during the aging process. May play a role in biosynthesis and/or processing of SLC2A4 in adipose cells. http://togogenome.org/gene/13616:FAXC ^@ http://purl.uniprot.org/uniprot/F7F1Y6 ^@ Similarity ^@ Belongs to the FAX family. http://togogenome.org/gene/13616:LOC100033268 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZI5 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:SPOP ^@ http://purl.uniprot.org/uniprot/A0A5F8GQH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tdpoz family.|||Nucleus speckle http://togogenome.org/gene/13616:monDomV1R1262 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC29A3 ^@ http://purl.uniprot.org/uniprot/F6PVB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/13616:TARS ^@ http://purl.uniprot.org/uniprot/F7BZE2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:SCAMP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/13616:LOC100030876 ^@ http://purl.uniprot.org/uniprot/A0A5F8H421 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:NIPBL ^@ http://purl.uniprot.org/uniprot/F7FKB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/13616:ITGB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/13616:CERS2 ^@ http://purl.uniprot.org/uniprot/F6YYM6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:RORC ^@ http://purl.uniprot.org/uniprot/A0A5F8G5E3|||http://purl.uniprot.org/uniprot/F6R6L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:BACE2 ^@ http://purl.uniprot.org/uniprot/F6SNE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane http://togogenome.org/gene/13616:FTO ^@ http://purl.uniprot.org/uniprot/A0A5F8GF52|||http://purl.uniprot.org/uniprot/A0A5F8GKL6|||http://purl.uniprot.org/uniprot/A0A5F8HA43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fto family.|||Belongs to the iron/ascorbate-dependent oxidoreductase family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/13616:ENTPD3 ^@ http://purl.uniprot.org/uniprot/F6TMK1 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:SHH ^@ http://purl.uniprot.org/uniprot/D5KSE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hedgehog family.|||Membrane http://togogenome.org/gene/13616:C7H2orf49 ^@ http://purl.uniprot.org/uniprot/F7B9F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ashwin family.|||Nucleus http://togogenome.org/gene/13616:FAM3A ^@ http://purl.uniprot.org/uniprot/F7BPN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/13616:SLC35A2 ^@ http://purl.uniprot.org/uniprot/F6TCY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/13616:CENPI ^@ http://purl.uniprot.org/uniprot/F7DFD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/13616:FBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJ19 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/13616:KCNA1 ^@ http://purl.uniprot.org/uniprot/F7EBT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:KDM3B ^@ http://purl.uniprot.org/uniprot/F7DHY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DBNDD2 ^@ http://purl.uniprot.org/uniprot/F7G8N2 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/13616:SNX32 ^@ http://purl.uniprot.org/uniprot/F6ZNH6 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/13616:CHMP4C ^@ http://purl.uniprot.org/uniprot/F7FS96 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0L5 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/13616:AP3B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK69|||http://purl.uniprot.org/uniprot/F6X3Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes large subunit family.|||Subunit of non-clathrin- and clathrin-associated adaptor protein complex 3 (AP-3) that plays a role in protein sorting in the late-Golgi/trans-Golgi network (TGN) and/or endosomes. The AP complexes mediate both the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules. AP-3 appears to be involved in the sorting of a subset of transmembrane proteins targeted to lysosomes and lysosome-related organelles. In concert with the BLOC-1 complex, AP-3 is required to target cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals.|||clathrin-coated vesicle membrane http://togogenome.org/gene/13616:TRIM72 ^@ http://purl.uniprot.org/uniprot/F7F5W4 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle membrane|||sarcolemma http://togogenome.org/gene/13616:SLC9C2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF06 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/13616:POLR2M ^@ http://purl.uniprot.org/uniprot/F7GET9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRINL1 family.|||Nucleus http://togogenome.org/gene/13616:SLC25A37 ^@ http://purl.uniprot.org/uniprot/F7G676 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:BRCA1 ^@ http://purl.uniprot.org/uniprot/F7CFT5|||http://purl.uniprot.org/uniprot/Q52P67 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Cytoplasm|||E3 ubiquitin-protein ligase that specifically mediates the formation of 'Lys-6'-linked polyubiquitin chains and plays a central role in DNA repair by facilitating cellular responses to DNA damage. It is unclear whether it also mediates the formation of other types of polyubiquitin chains. The BRCA1-BARD1 heterodimer coordinates a diverse range of cellular pathways such as DNA damage repair, ubiquitination and transcriptional regulation to maintain genomic stability. Regulates centrosomal microtubule nucleation. Required for appropriate cell cycle arrests after ionizing irradiation in both the S-phase and the G2 phase of the cell cycle. Required for FANCD2 targeting to sites of DNA damage. Inhibits lipid synthesis by binding to inactive phosphorylated ACACA and preventing its dephosphorylation. Contributes to homologous recombination repair (HRR) via its direct interaction with PALB2, fine-tunes recombinational repair partly through its modulatory role in the PALB2-dependent loading of BRCA2-RAD51 repair machinery at DNA breaks. Component of the BRCA1-RBBP8 complex which regulates CHEK1 activation and controls cell cycle G2/M checkpoints on DNA damage via BRCA1-mediated ubiquitination of RBBP8. Acts as a transcriptional activator.|||Heterodimer with BARD1. Part of the BRCA1-associated genome surveillance complex (BASC), which contains BRCA1, MSH2, MSH6, MLH1, ATM, BLM, PMS2 and the MRE11-RAD50-NBN protein (MRN) complex. This association could be a dynamic process changing throughout the cell cycle and within subnuclear domains. Component of the BRCA1-A complex, at least composed of BRCA1, BARD1, UIMC1/RAP80, ABRAXAS1, BRCC3/BRCC36, BABAM2 and BABAM1/NBA1. Interacts (via the BRCT domains) with ABRAXAS1 (phosphorylated form); this is important for recruitment to sites of DNA damage. Can form a heterotetramer with two molecules of ABRAXAS1 (phosphorylated form). Component of the BRCA1-RBBP8 complex. Interacts (via the BRCT domains) with RBBP8 ('Ser-327' phosphorylated form); the interaction ubiquitinates RBBP8, regulates CHEK1 activation, and involves RBBP8 in BRCA1-dependent G2/M checkpoint control on DNA damage. Associates with RNA polymerase II holoenzyme. Interacts with SMC1A, NELFB, DCLRE1C, CLSPN. CHEK1, CHEK2, BAP1, BRCC3, UBXN1 and PCLAF. Interacts (via BRCT domains) with BRIP1 (phosphorylated form). Interacts with FANCD2 (ubiquitinated form). Interacts with H2AX (phosphorylated on 'Ser-140'). Interacts (via the BRCT domains) with ACACA (phosphorylated form); the interaction prevents dephosphorylation of ACACA. Part of a BRCA complex containing BRCA1, BRCA2 and PALB2. Interacts directly with PALB2; the interaction is essential for its function in HRR. Interacts directly with BRCA2; the interaction occurs only in the presence of PALB2 which serves as the bridging protein. Interacts (via the BRCT domains) with LMO4; the interaction represses the transcriptional activity of BRCA1. Interacts (via the BRCT domains) with CCAR2 (via N-terminus); the interaction represses the transcriptional activator activity of BRCA1. Interacts with EXD2. Interacts (via C-terminus) with DHX9; this interaction is direct and links BRCA1 to the RNA polymerase II holoenzyme.|||Nucleus http://togogenome.org/gene/13616:UCP1 ^@ http://purl.uniprot.org/uniprot/F6X9Y8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||May undergo ubiquitin-mediated proteasomal degradation.|||Membrane|||Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates in non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent transport of protons activated by LCFAs. Thereby, dissipates the mitochondrial proton gradient and converts the energy of substrate oxydation into heat instead of ATP. Regulates the production of reactive oxygen species/ROS by mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:POLR2A ^@ http://purl.uniprot.org/uniprot/F6XTX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/13616:CPO ^@ http://purl.uniprot.org/uniprot/F7EZD6 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:EVA1B ^@ http://purl.uniprot.org/uniprot/F6ZXB4 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/13616:CORIN ^@ http://purl.uniprot.org/uniprot/F6ZAT4 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PPP1R21 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3R8 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:PRKG2 ^@ http://purl.uniprot.org/uniprot/F6YKH9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/13616:CPSF3L ^@ http://purl.uniprot.org/uniprot/F7CAF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Nucleus http://togogenome.org/gene/13616:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/13616:LOC100017328 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:IL17RB ^@ http://purl.uniprot.org/uniprot/A0A5F8G9B2|||http://purl.uniprot.org/uniprot/F6Q0J4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100022107 ^@ http://purl.uniprot.org/uniprot/F6PZT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100018705 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/13616:THAP1 ^@ http://purl.uniprot.org/uniprot/F6XLQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||Interacts with PAWR. Component of a THAP1/THAP3-HCFC1-OGT complex that contains, either THAP1 or THAP3, HCFC1 and OGT. Interacts with OGT. Interacts (via the HBM) with HCFC1 (via the Kelch-repeat domain); the interaction recruits HCFC1 to the RRM1 promoter.|||nucleoplasm http://togogenome.org/gene/13616:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJM6|||http://purl.uniprot.org/uniprot/F6R812 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:CEP19 ^@ http://purl.uniprot.org/uniprot/F7CUD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/13616:ANO4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4Q0|||http://purl.uniprot.org/uniprot/A0A5F8HAA1|||http://purl.uniprot.org/uniprot/F7FL71 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ASAH1 ^@ http://purl.uniprot.org/uniprot/F7BKX1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/13616:TM4SF20 ^@ http://purl.uniprot.org/uniprot/F6UGK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/13616:TMTC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKU3|||http://purl.uniprot.org/uniprot/F6UAD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/13616:COMP ^@ http://purl.uniprot.org/uniprot/F7AZT2 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:C2H6orf89 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHL3|||http://purl.uniprot.org/uniprot/F7F8J5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100027703 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI21|||http://purl.uniprot.org/uniprot/F7DDL6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/13616:RRP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFN1 ^@ Similarity ^@ Belongs to the RRP1 family. http://togogenome.org/gene/13616:CHFR ^@ http://purl.uniprot.org/uniprot/F6TMI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/13616:TRIM45 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEA8|||http://purl.uniprot.org/uniprot/A0A5F8H696|||http://purl.uniprot.org/uniprot/F7E8F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/13616:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN53|||http://purl.uniprot.org/uniprot/A0A5F8HIA8|||http://purl.uniprot.org/uniprot/F7FD05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DDX52 ^@ http://purl.uniprot.org/uniprot/F7BVL7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/13616:monDomV1R1261 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FXR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G660 ^@ Similarity ^@ Belongs to the FMR1 family. http://togogenome.org/gene/13616:PDRG1 ^@ http://purl.uniprot.org/uniprot/F6WAE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Component of the PAQosome complex which is responsible for the biogenesis of several protein complexes and which consists of R2TP complex members RUVBL1, RUVBL2, RPAP3 and PIH1D1, URI complex members PFDN2, PFDN6, PDRG1, UXT and URI1 as well as ASDURF, POLR2E and DNAAF10/WDR92.|||Cytoplasm|||May play a role in chaperone-mediated protein folding. http://togogenome.org/gene/13616:HINT2 ^@ http://purl.uniprot.org/uniprot/F6RG00 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/13616:NRN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMV9 ^@ Similarity ^@ Belongs to the neuritin family. http://togogenome.org/gene/13616:LOC100018981 ^@ http://purl.uniprot.org/uniprot/F6U150 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100024568 ^@ http://purl.uniprot.org/uniprot/F6PJ15 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:PPP1R3C ^@ http://purl.uniprot.org/uniprot/F7CCR6 ^@ Domain|||Function|||Subunit ^@ Acts as a glycogen-targeting subunit for PP1 and regulates its activity. Activates glycogen synthase, reduces glycogen phosphorylase activity and limits glycogen breakdown.|||Interacts with PPP1CC catalytic subunit of PP1 and associates with glycogen. Forms complexes with glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity.|||The N-terminal region is required for binding to PP1, the central region is required for binding to glycogen and the C-terminal region is required for binding to glycogen phosphorylase glycogen synthase and phosphorylase kinase. http://togogenome.org/gene/13616:SMC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G848 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/13616:ANKRD13B ^@ http://purl.uniprot.org/uniprot/F6REP0 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/13616:CDC14B ^@ http://purl.uniprot.org/uniprot/F6XN43 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/13616:CA9 ^@ http://purl.uniprot.org/uniprot/F7CQP4 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:RAB3IP ^@ http://purl.uniprot.org/uniprot/F7F670 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/13616:NOTUM ^@ http://purl.uniprot.org/uniprot/F6WU00 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/13616:HHIP ^@ http://purl.uniprot.org/uniprot/A0A5F8G8G3|||http://purl.uniprot.org/uniprot/F6UT79 ^@ Caution|||Similarity ^@ Belongs to the HHIP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:APOOL ^@ http://purl.uniprot.org/uniprot/F6V4X4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:GUCA2A ^@ http://purl.uniprot.org/uniprot/F6WWL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/13616:DRD2 ^@ http://purl.uniprot.org/uniprot/F6TRD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:CEMIP ^@ http://purl.uniprot.org/uniprot/F6SZF3 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/13616:FGF20 ^@ http://purl.uniprot.org/uniprot/F7AXM6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:TPRKB ^@ http://purl.uniprot.org/uniprot/F6V6G9 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/13616:MESDC2 ^@ http://purl.uniprot.org/uniprot/F6SZG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MESD family.|||Endoplasmic reticulum http://togogenome.org/gene/13616:C9 ^@ http://purl.uniprot.org/uniprot/F7G7P1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/13616:NEK8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJF8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/13616:PIPOX ^@ http://purl.uniprot.org/uniprot/A0A5F8H7Q1 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/13616:ATXN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G217|||http://purl.uniprot.org/uniprot/A0A5F8HC13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100024051 ^@ http://purl.uniprot.org/uniprot/F7EHY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRQ3|||http://purl.uniprot.org/uniprot/F6T5Z0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOX ^@ http://purl.uniprot.org/uniprot/F7F939 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/13616:SOX14 ^@ http://purl.uniprot.org/uniprot/F6XNT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GNAL ^@ http://purl.uniprot.org/uniprot/F7CB49 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/13616:LOC100013113 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:LOC100018962 ^@ http://purl.uniprot.org/uniprot/F6V6L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LAMTOR3 ^@ http://purl.uniprot.org/uniprot/F7DKI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.|||Belongs to the LAMTOR3 family.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/13616:IFN2 ^@ http://purl.uniprot.org/uniprot/A8E6E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:KCNMB3 ^@ http://purl.uniprot.org/uniprot/F7G3H8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/13616:AGPAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G731 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/13616:LOC100013358 ^@ http://purl.uniprot.org/uniprot/F6X5U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ETF1 ^@ http://purl.uniprot.org/uniprot/F7FU88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/13616:GALR1 ^@ http://purl.uniprot.org/uniprot/F6YFW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4R1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/13616:SDCCAG3 ^@ http://purl.uniprot.org/uniprot/F7BSG6 ^@ Similarity ^@ Belongs to the ENTR1 family. http://togogenome.org/gene/13616:LOC103094304 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:HMBS ^@ http://purl.uniprot.org/uniprot/F6ZKA2 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/13616:LOC100023336 ^@ http://purl.uniprot.org/uniprot/K7E6E7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:MKS1 ^@ http://purl.uniprot.org/uniprot/F6YN29 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/13616:TSPAN33 ^@ http://purl.uniprot.org/uniprot/F7DNN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:TCP1 ^@ http://purl.uniprot.org/uniprot/Q9XT06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the chaperonin-containing T-complex (TRiC), a heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. Interacts with PACRG. Interacts with GBA1 (By similarity). Interacts with DLEC1 (By similarity).|||Component of the chaperonin-containing T-complex (TRiC), a molecular chaperone complex that assists the folding of proteins upon ATP hydrolysis. The TRiC complex mediates the folding of WRAP53/TCAB1, thereby regulating telomere maintenance. As part of the TRiC complex may play a role in the assembly of BBSome, a complex involved in ciliogenesis regulating transports vesicles to the cilia. The TRiC complex plays a role in the folding of actin and tubulin.|||centrosome|||cytosol http://togogenome.org/gene/13616:TMEM201 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM201 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/13616:TOP3A ^@ http://purl.uniprot.org/uniprot/F6QP60 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/13616:HMGB3 ^@ http://purl.uniprot.org/uniprot/C7E652 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/13616:YWHAZ ^@ http://purl.uniprot.org/uniprot/F7BS95 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:LOC100027041 ^@ http://purl.uniprot.org/uniprot/F7AWC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:LOC100014688 ^@ http://purl.uniprot.org/uniprot/F7CUK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6K3 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/13616:CMTM6 ^@ http://purl.uniprot.org/uniprot/F7BVQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PAH ^@ http://purl.uniprot.org/uniprot/A0A5F8GPC2 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/13616:LOC100028573 ^@ http://purl.uniprot.org/uniprot/F6V606 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:PRKCH ^@ http://purl.uniprot.org/uniprot/F6PWG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/13616:CHDH ^@ http://purl.uniprot.org/uniprot/F6PZX9 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/13616:COPG1 ^@ http://purl.uniprot.org/uniprot/F7F307 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/13616:ARSI ^@ http://purl.uniprot.org/uniprot/F6RZZ5 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:FAM76A ^@ http://purl.uniprot.org/uniprot/A0A5F8G818|||http://purl.uniprot.org/uniprot/A0A5F8GV49 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/13616:MURC ^@ http://purl.uniprot.org/uniprot/A0A5F8HHK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/13616:NAF1 ^@ http://purl.uniprot.org/uniprot/K7E2M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/13616:NOTCH4 ^@ http://purl.uniprot.org/uniprot/F6SDD3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOTCH family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Nucleus http://togogenome.org/gene/13616:GUCY1B3 ^@ http://purl.uniprot.org/uniprot/F7AMU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100027227 ^@ http://purl.uniprot.org/uniprot/F7B0S5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/13616:EMC4 ^@ http://purl.uniprot.org/uniprot/F6SR81 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC4 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:DFNB59 ^@ http://purl.uniprot.org/uniprot/F7EF78 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/13616:MRPL2 ^@ http://purl.uniprot.org/uniprot/F7FNZ9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/13616:SLC24A5 ^@ http://purl.uniprot.org/uniprot/F6YH24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/13616:SMG1 ^@ http://purl.uniprot.org/uniprot/F7F0R6 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/13616:PAN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIE9|||http://purl.uniprot.org/uniprot/F7FR09 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/13616:FEV ^@ http://purl.uniprot.org/uniprot/F6WXL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:PLAG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHU1|||http://purl.uniprot.org/uniprot/A0A5F8HEM6 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/13616:ATP6V1B2 ^@ http://purl.uniprot.org/uniprot/F6RX69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits. http://togogenome.org/gene/13616:SPSB1 ^@ http://purl.uniprot.org/uniprot/F7EE24 ^@ Similarity ^@ Belongs to the SPSB family. http://togogenome.org/gene/13616:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ07|||http://purl.uniprot.org/uniprot/A0A5F8H7D7|||http://purl.uniprot.org/uniprot/F6REU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|||sarcolemma http://togogenome.org/gene/13616:LOC100031528 ^@ http://purl.uniprot.org/uniprot/F7C2Y2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PMEPA1 ^@ http://purl.uniprot.org/uniprot/F7EQ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:LOC100618856 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DDAH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Q3|||http://purl.uniprot.org/uniprot/A0A5F8H3U8 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/13616:LOC100028963 ^@ http://purl.uniprot.org/uniprot/F7BJB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100013070 ^@ http://purl.uniprot.org/uniprot/F7C2H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031231 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8P4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:ECE1 ^@ http://purl.uniprot.org/uniprot/F7EYY6 ^@ Function ^@ Converts big endothelin-1 to endothelin-1. http://togogenome.org/gene/13616:PFN1 ^@ http://purl.uniprot.org/uniprot/F7DMM7 ^@ Similarity ^@ Belongs to the profilin family. http://togogenome.org/gene/13616:LOC100018677 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLC4|||http://purl.uniprot.org/uniprot/F6WWR9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:ZDHHC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJH6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:EOGT ^@ http://purl.uniprot.org/uniprot/F7DWT3 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/13616:LOC100015103 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8R6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/13616:LIN7C ^@ http://purl.uniprot.org/uniprot/F7FZJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the lin-7 family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Plays a role in establishing and maintaining the asymmetric distribution of channels and receptors at the plasma membrane of polarized cells.|||Postsynaptic density membrane|||tight junction http://togogenome.org/gene/13616:GAPDHS ^@ http://purl.uniprot.org/uniprot/F6VBR8 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/13616:LOC100020065 ^@ http://purl.uniprot.org/uniprot/F7C6I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:MAPK10 ^@ http://purl.uniprot.org/uniprot/A0A5F8G214|||http://purl.uniprot.org/uniprot/A0A5F8GE43|||http://purl.uniprot.org/uniprot/F6ZA47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/13616:MMP13 ^@ http://purl.uniprot.org/uniprot/F6SS23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CCN2. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CCN2. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.|||Secreted http://togogenome.org/gene/13616:SLC25A39 ^@ http://purl.uniprot.org/uniprot/F6QCC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:GABRA1 ^@ http://purl.uniprot.org/uniprot/F7EUF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA1 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:NAGK ^@ http://purl.uniprot.org/uniprot/F6SQY9 ^@ Similarity ^@ Belongs to the eukaryotic-type N-acetylglucosamine kinase family. http://togogenome.org/gene/13616:FAM26F ^@ http://purl.uniprot.org/uniprot/F6Z8E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:SLC17A9 ^@ http://purl.uniprot.org/uniprot/F6R209 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:REEP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/13616:FAM161B ^@ http://purl.uniprot.org/uniprot/F7AK18 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/13616:MEOX1 ^@ http://purl.uniprot.org/uniprot/F7BW00 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY66|||http://purl.uniprot.org/uniprot/F7A567 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/13616:EXOC6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7R6|||http://purl.uniprot.org/uniprot/F7EZ69 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/13616:STRN ^@ http://purl.uniprot.org/uniprot/A0A5F8H540|||http://purl.uniprot.org/uniprot/F6WH28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/13616:DUS3L ^@ http://purl.uniprot.org/uniprot/F7FWB8 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/13616:GTPBP4 ^@ http://purl.uniprot.org/uniprot/F6TMC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/13616:SARS ^@ http://purl.uniprot.org/uniprot/F6YEX7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/13616:PREB ^@ http://purl.uniprot.org/uniprot/F7B5V1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Guanine nucleotide exchange factor that specifically activates the small GTPase SAR1B. Mediates the recruitment of SAR1B and other COPII coat components to endoplasmic reticulum membranes and is therefore required for the formation of COPII transport vesicles from the ER.|||Interacts with SAR1B (GDP-bound form). Interacts with MIA2; recruits PREB to endoplasmic reticulum exit sites.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Was first identified based on its probable role in the regulation of pituitary gene transcription. Binds to the prolactin gene (PRL) promoter and seems to activate transcription. http://togogenome.org/gene/13616:SERPINB7 ^@ http://purl.uniprot.org/uniprot/F7CGZ0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:LOC100012064 ^@ http://purl.uniprot.org/uniprot/K7E2A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1204 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CHPF2 ^@ http://purl.uniprot.org/uniprot/F6SCG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:EMX2 ^@ http://purl.uniprot.org/uniprot/F7CPI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MANF ^@ http://purl.uniprot.org/uniprot/F7EGP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARMET family.|||Secreted http://togogenome.org/gene/13616:KEAP1 ^@ http://purl.uniprot.org/uniprot/F6QE74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KEAP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100024753 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ANTXRL ^@ http://purl.uniprot.org/uniprot/F6W852 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/13616:LOC100020439 ^@ http://purl.uniprot.org/uniprot/F6TUR3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:POLR2H ^@ http://purl.uniprot.org/uniprot/A0A5F8G371 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/13616:ALKBH5 ^@ http://purl.uniprot.org/uniprot/F6XQJ4 ^@ Subcellular Location Annotation|||Subunit ^@ Monomer.|||Nucleus speckle http://togogenome.org/gene/13616:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A5F8H1J0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Interacts with mitochondrial RNA polymerase POLRMT. Interacts with TFAM.|||S-adenosyl-L-methionine-dependent methyltransferase which specifically dimethylates mitochondrial 12S rRNA at the conserved stem loop. Also required for basal transcription of mitochondrial DNA, probably via its interaction with POLRMT and TFAM. Stimulates transcription independently of the methyltransferase activity. http://togogenome.org/gene/13616:GNB1 ^@ http://purl.uniprot.org/uniprot/F6PVT7 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/13616:GPR87 ^@ http://purl.uniprot.org/uniprot/F7GEB2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:VN2R597 ^@ http://purl.uniprot.org/uniprot/F7GHA0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RBP1 ^@ http://purl.uniprot.org/uniprot/F7BQ15 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:CAPN9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHT2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/13616:MAK16 ^@ http://purl.uniprot.org/uniprot/F7DL52 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/13616:SLC12A6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEB6|||http://purl.uniprot.org/uniprot/F6X0B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/13616:RIMKLB ^@ http://purl.uniprot.org/uniprot/F7B7U4 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/13616:FSHB ^@ http://purl.uniprot.org/uniprot/Q95J82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer. The active follitropin is a heterodimer composed of an alpha chain/CGA shared with other hormones and a unique beta chain/FSHB shown here.|||Secreted|||Together with the alpha chain CGA constitutes follitropin, the follicle-stimulating hormone, and provides its biological specificity to the hormone heterodimer. Binds FSHR, a G protein-coupled receptor, on target cells to activate downstream signaling pathways. Follitropin is involved in follicle development and spermatogenesis in reproductive organs. http://togogenome.org/gene/13616:RECQL4 ^@ http://purl.uniprot.org/uniprot/F7FVC5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100025649 ^@ http://purl.uniprot.org/uniprot/F6YZZ1 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/13616:IL17A ^@ http://purl.uniprot.org/uniprot/F6YYN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/13616:DOK3 ^@ http://purl.uniprot.org/uniprot/F6U708 ^@ Similarity ^@ Belongs to the DOK family. Type A subfamily. http://togogenome.org/gene/13616:NINJ2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2D1|||http://purl.uniprot.org/uniprot/A0A5F8G3Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/13616:LOC100013458 ^@ http://purl.uniprot.org/uniprot/F7GHY7 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/13616:SLC30A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100618597 ^@ http://purl.uniprot.org/uniprot/F7D893 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGX5|||http://purl.uniprot.org/uniprot/A0A5F8GKV8|||http://purl.uniprot.org/uniprot/A0A5F8H946|||http://purl.uniprot.org/uniprot/F7AUH6 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/13616:VN2R618 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJR3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ACTR6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3U6|||http://purl.uniprot.org/uniprot/A0A5F8GWN0|||http://purl.uniprot.org/uniprot/F7F5S1 ^@ Similarity ^@ Belongs to the actin family. ARP6 subfamily. http://togogenome.org/gene/13616:LOC100013044 ^@ http://purl.uniprot.org/uniprot/F6SDJ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/13616:TMCO3 ^@ http://purl.uniprot.org/uniprot/F6ZKN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GABRB3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC100030396 ^@ http://purl.uniprot.org/uniprot/F7AP39 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/13616:LOC100015605 ^@ http://purl.uniprot.org/uniprot/F7AAB2 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:LOC103102954 ^@ http://purl.uniprot.org/uniprot/F6TAY5 ^@ Similarity ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family. http://togogenome.org/gene/13616:FAR1 ^@ http://purl.uniprot.org/uniprot/F6XVM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acyl-CoA reductase family.|||Catalyzes the reduction of fatty acyl-CoA to fatty alcohols.|||Peroxisome membrane http://togogenome.org/gene/13616:ACTL8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQT3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:GPRC5A ^@ http://purl.uniprot.org/uniprot/F6PGM6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RAP2B ^@ http://purl.uniprot.org/uniprot/F7DGX0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Palmitoylated.|||Recycling endosome membrane|||Small GTP-binding protein which cycles between a GDP-bound inactive and a GTP-bound active form. http://togogenome.org/gene/13616:AP4S1 ^@ http://purl.uniprot.org/uniprot/F7B5W0 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/13616:VN2R551 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQV1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/F7AD72 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/13616:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/F6UI11 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:SCAMP2 ^@ http://purl.uniprot.org/uniprot/F7DA26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/13616:COG6 ^@ http://purl.uniprot.org/uniprot/F6SS12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/13616:DUPD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G707 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:HOXA10 ^@ http://purl.uniprot.org/uniprot/F6URM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:ACTL7A ^@ http://purl.uniprot.org/uniprot/F6XB70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Golgi apparatus|||May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.|||Nucleus|||cytoskeleton http://togogenome.org/gene/13616:CCM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7F0 ^@ Similarity ^@ Belongs to the CCM2 family. http://togogenome.org/gene/13616:AGMAT ^@ http://purl.uniprot.org/uniprot/F7GBU4 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/13616:PIGO ^@ http://purl.uniprot.org/uniprot/F7AFE5|||http://purl.uniprot.org/uniprot/F7BJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100025737 ^@ http://purl.uniprot.org/uniprot/F6U4R6 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/13616:MMD ^@ http://purl.uniprot.org/uniprot/F7BZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:MYB ^@ http://purl.uniprot.org/uniprot/A0A5F8GMD6|||http://purl.uniprot.org/uniprot/F7FEQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CNOT7 ^@ http://purl.uniprot.org/uniprot/F7AXX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/13616:KLHL15 ^@ http://purl.uniprot.org/uniprot/F7F5Y0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TLR3 ^@ http://purl.uniprot.org/uniprot/F6TNZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/13616:HEXA ^@ http://purl.uniprot.org/uniprot/F6WJB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/13616:PDE9A ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Q8|||http://purl.uniprot.org/uniprot/F7FKQ2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:LUC7L3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH27 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/13616:GDAP1 ^@ http://purl.uniprot.org/uniprot/F6RGH2 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/13616:GUSB ^@ http://purl.uniprot.org/uniprot/F7EJZ4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Homotetramer.|||Inhibited by L-aspartic acid.|||Lysosome|||Plays an important role in the degradation of dermatan and keratan sulfates. http://togogenome.org/gene/13616:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC77|||http://purl.uniprot.org/uniprot/A0A5F8HKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/13616:MAPK9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYR6|||http://purl.uniprot.org/uniprot/F6WV79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/13616:LFNG ^@ http://purl.uniprot.org/uniprot/F6YBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LPAR5 ^@ http://purl.uniprot.org/uniprot/F7FFQ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:COPS3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:WNT2 ^@ http://purl.uniprot.org/uniprot/Q2QL96 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors. Functions in the canonical Wnt signaling pathway that results in activation of transcription factors of the TCF/LEF family (By similarity). Functions as upstream regulator of FGF10 expression. Plays an important role in embryonic lung development. May contribute to embryonic brain development by regulating the proliferation of dopaminergic precursors and neurons (By similarity).|||Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.|||Secreted|||extracellular matrix http://togogenome.org/gene/13616:PPA2 ^@ http://purl.uniprot.org/uniprot/F7EMS4 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/13616:STRN3 ^@ http://purl.uniprot.org/uniprot/F7BS62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/13616:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRV1|||http://purl.uniprot.org/uniprot/F7DMB1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/13616:ORC2 ^@ http://purl.uniprot.org/uniprot/F7FHI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/13616:MMP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9W3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M10A family.|||Interacts (via the C-terminal hemopexin-like domains-containing region) with the integrin alpha-V/beta-3; the interaction promotes vascular invasion in angiogenic vessels and melamoma cells. Interacts (via the C-terminal PEX domain) with TIMP2 (via the C-terminal); the interaction inhibits the degradation activity. Interacts with GSK3B.|||extracellular matrix http://togogenome.org/gene/13616:ONECUT1 ^@ http://purl.uniprot.org/uniprot/F6Z5A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/13616:TUBB6 ^@ http://purl.uniprot.org/uniprot/F7CB79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:FAHD2A ^@ http://purl.uniprot.org/uniprot/F7CKR3 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/13616:SLC25A33 ^@ http://purl.uniprot.org/uniprot/F6PNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:ALB ^@ http://purl.uniprot.org/uniprot/F7BJP5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:AKAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4E3|||http://purl.uniprot.org/uniprot/A0A5F8HEI0|||http://purl.uniprot.org/uniprot/A0A5F8HJB2|||http://purl.uniprot.org/uniprot/F6V5J9|||http://purl.uniprot.org/uniprot/F6W529 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/13616:LOC100011319 ^@ http://purl.uniprot.org/uniprot/F6UXG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLAIN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2F5|||http://purl.uniprot.org/uniprot/F7FHX9 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/13616:EXOSC3 ^@ http://purl.uniprot.org/uniprot/F6Q542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm http://togogenome.org/gene/13616:CDC37L1 ^@ http://purl.uniprot.org/uniprot/F6TL51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/13616:GOLGA5 ^@ http://purl.uniprot.org/uniprot/F7GEH2 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.|||Membrane http://togogenome.org/gene/13616:DUT ^@ http://purl.uniprot.org/uniprot/F7CYM7 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/13616:GLRA1 ^@ http://purl.uniprot.org/uniprot/F7G2F3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/13616:NCF2 ^@ http://purl.uniprot.org/uniprot/F6XAM8 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/13616:ANO3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUT3|||http://purl.uniprot.org/uniprot/F7CQ03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Membrane http://togogenome.org/gene/13616:PYCR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2X3 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/13616:RPS27 ^@ http://purl.uniprot.org/uniprot/F6SM23 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:MTMR4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7D5|||http://purl.uniprot.org/uniprot/A0A5F8HDQ1|||http://purl.uniprot.org/uniprot/F7D3Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:GUCA2B ^@ http://purl.uniprot.org/uniprot/F6WWK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/13616:AKAP12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQS1|||http://purl.uniprot.org/uniprot/A0A5F8HA15|||http://purl.uniprot.org/uniprot/A0A5F8HDM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ATP6V1G1 ^@ http://purl.uniprot.org/uniprot/F6QN45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:LOC100029871 ^@ http://purl.uniprot.org/uniprot/F7BKP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases. They oxidize a variety of structurally unrelated compounds, including steroids, fatty acids, and xenobiotics.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:XRCC3 ^@ http://purl.uniprot.org/uniprot/F7D6P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/13616:GH1 ^@ http://purl.uniprot.org/uniprot/Q9GL60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Plays an important role in growth control. Its major role in stimulating body growth is to stimulate the liver and other tissues to secrete IGF-1. It stimulates both the differentiation and proliferation of myoblasts. It also stimulates amino acid uptake and protein synthesis in muscle and other tissues (By similarity).|||Secreted http://togogenome.org/gene/13616:DYRK3 ^@ http://purl.uniprot.org/uniprot/F6UZJ2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/13616:HAUS1 ^@ http://purl.uniprot.org/uniprot/F6TZI7|||http://purl.uniprot.org/uniprot/K7E4I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/13616:HYAL3 ^@ http://purl.uniprot.org/uniprot/F7CYI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Membrane|||acrosome http://togogenome.org/gene/13616:LRRC8B ^@ http://purl.uniprot.org/uniprot/F7G4V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NUDCD1 ^@ http://purl.uniprot.org/uniprot/F7BGF0 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:C6H16orf71 ^@ http://purl.uniprot.org/uniprot/K7E4S6 ^@ Function ^@ In cyliated cells, dynein axonemal particle-specific protein required for deployment of ODA to the axoneme. Interacts with outer dynein arm (ODA) subunits. http://togogenome.org/gene/13616:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A5F8G524 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/13616:RPL21 ^@ http://purl.uniprot.org/uniprot/F7GL67 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/13616:FAM83G ^@ http://purl.uniprot.org/uniprot/F7F4V4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/13616:VPS11 ^@ http://purl.uniprot.org/uniprot/F6ZJC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/13616:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3C5|||http://purl.uniprot.org/uniprot/A0A5F8HBD7|||http://purl.uniprot.org/uniprot/F6UA19 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/13616:AR ^@ http://purl.uniprot.org/uniprot/F6PME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/13616:GNAQ ^@ http://purl.uniprot.org/uniprot/F7G1K7 ^@ Similarity ^@ Belongs to the G-alpha family. G(q) subfamily. http://togogenome.org/gene/13616:LOC100018537 ^@ http://purl.uniprot.org/uniprot/F7DXV9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/13616:IRX5 ^@ http://purl.uniprot.org/uniprot/F7EWI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/13616:ALDH1B1 ^@ http://purl.uniprot.org/uniprot/F7C0D1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/13616:SLC25A36 ^@ http://purl.uniprot.org/uniprot/F7B318 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100026625 ^@ http://purl.uniprot.org/uniprot/F6TKJ5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EEF2KMT family. http://togogenome.org/gene/13616:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/F7G7C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:LOC100031974 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3B9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100028995 ^@ http://purl.uniprot.org/uniprot/F7BQ48 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VASN ^@ http://purl.uniprot.org/uniprot/A0A5F8GZI3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100012591 ^@ http://purl.uniprot.org/uniprot/F6QSG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SYNGR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSF9|||http://purl.uniprot.org/uniprot/A0A5F8GZX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/13616:CDX1 ^@ http://purl.uniprot.org/uniprot/F6XTN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/13616:USP14 ^@ http://purl.uniprot.org/uniprot/F7G2Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase C19 family. USP14/UBP6 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homodimer (Potential). Associates with the 26S proteasome. Interacts with FANCC, CXCR4 and ERN1. Interacts with TRIM14; this interaction recruits USP14 to cleave ubiquitin chains of CGAS. http://togogenome.org/gene/13616:MAF1 ^@ http://purl.uniprot.org/uniprot/F7EAC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Element of the TORC1 signaling pathway that acts as a mediator of diverse signals and that represses RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA.|||Nucleus http://togogenome.org/gene/13616:LOC103103296 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC23A2 ^@ http://purl.uniprot.org/uniprot/F6U0C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/13616:TMEM94 ^@ http://purl.uniprot.org/uniprot/F6YYK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CGA ^@ http://purl.uniprot.org/uniprot/Q6YNX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer. The active hormones thyrotropin, lutropin and follitropin are heterodimers composed of CGA, a common alpha chain described here and a unique beta chain which confers their biological specificity to the hormones: TSHB for thyrotropin, LHB for lutropin and FSHB for follitropin.|||Secreted|||Shared alpha chain of the active heterodimeric glycoprotein hormones thyrotropin/thyroid stimulating hormone/TSH, lutropin/luteinizing hormone/LH and follitropin/follicle stimulating hormone/FSH. These hormones bind specific receptors on target cells that in turn activate downstream signaling pathways. http://togogenome.org/gene/13616:MDM4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9Z5|||http://purl.uniprot.org/uniprot/F7BAJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Inhibits p53- and p73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain.|||Nucleus http://togogenome.org/gene/13616:ELK4 ^@ http://purl.uniprot.org/uniprot/F6T5N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4J3|||http://purl.uniprot.org/uniprot/A0A5F8HIS3|||http://purl.uniprot.org/uniprot/F6TST1 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/13616:LOC100015365 ^@ http://purl.uniprot.org/uniprot/A0A5F8G632 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/13616:NME3 ^@ http://purl.uniprot.org/uniprot/F7DRU3 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/13616:LOC100022188 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGM0 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/13616:LOC100020266 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VCP ^@ http://purl.uniprot.org/uniprot/F6ZIF4 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/13616:C2H17orf105 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE01 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/13616:CCDC153 ^@ http://purl.uniprot.org/uniprot/F7ECW8 ^@ Similarity ^@ Belongs to the UPF0610 family. http://togogenome.org/gene/13616:BHMT ^@ http://purl.uniprot.org/uniprot/F6X4V0 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/13616:MTHFR ^@ http://purl.uniprot.org/uniprot/A0A5F8GXA9|||http://purl.uniprot.org/uniprot/F7AQ98 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/13616:SLC25A41 ^@ http://purl.uniprot.org/uniprot/F6VJ46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBH3|||http://purl.uniprot.org/uniprot/F7AGZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:COG1 ^@ http://purl.uniprot.org/uniprot/F7F869 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/13616:GLUL ^@ http://purl.uniprot.org/uniprot/F6PH60 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/13616:GLDC ^@ http://purl.uniprot.org/uniprot/F6V2Z8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/13616:GGPS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Y3 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/13616:MAP3K6 ^@ http://purl.uniprot.org/uniprot/F6ZG40 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/13616:MTHFD1L ^@ http://purl.uniprot.org/uniprot/F7GGC9 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/13616:EVC2 ^@ http://purl.uniprot.org/uniprot/F6XGD8 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/13616:MED18 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:MAPK7 ^@ http://purl.uniprot.org/uniprot/F6YQF9 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/13616:PPP4R3B ^@ http://purl.uniprot.org/uniprot/F6W0L9 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/13616:ATXN1 ^@ http://purl.uniprot.org/uniprot/F7BE53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/13616:OPN1LW ^@ http://purl.uniprot.org/uniprot/B9MSR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100016646 ^@ http://purl.uniprot.org/uniprot/F6ZJ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/13616:LOC100028162 ^@ http://purl.uniprot.org/uniprot/F6TW41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:AP1G1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3R4|||http://purl.uniprot.org/uniprot/F7EH71 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Z1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/13616:SCAP ^@ http://purl.uniprot.org/uniprot/F6X2Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/13616:KEG11_p04 ^@ http://purl.uniprot.org/uniprot/Q65CI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:LOC100020348 ^@ http://purl.uniprot.org/uniprot/F6YGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:B3GAT3 ^@ http://purl.uniprot.org/uniprot/F6ZIQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:SLC17A6 ^@ http://purl.uniprot.org/uniprot/F6YX10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FLNA ^@ http://purl.uniprot.org/uniprot/A0A5F8GAD9 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/13616:ARRB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9J9 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/13616:TPST2 ^@ http://purl.uniprot.org/uniprot/F7G7U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/13616:LOC100027575 ^@ http://purl.uniprot.org/uniprot/A0A5F8GC63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FGF17 ^@ http://purl.uniprot.org/uniprot/F6SHQ2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:UCN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/13616:LOC100012618 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI30|||http://purl.uniprot.org/uniprot/F7FZ47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SSTR1 ^@ http://purl.uniprot.org/uniprot/F7AMI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ART1 ^@ http://purl.uniprot.org/uniprot/F6ZXV5 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/13616:EWSR1 ^@ http://purl.uniprot.org/uniprot/F6PFT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/13616:FMR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMX8|||http://purl.uniprot.org/uniprot/A0A5F8GRP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/13616:LOC103096822 ^@ http://purl.uniprot.org/uniprot/F6QYH1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/13616:TOP2B ^@ http://purl.uniprot.org/uniprot/F7D0D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:ARL6 ^@ http://purl.uniprot.org/uniprot/F6QF28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/13616:CECR6 ^@ http://purl.uniprot.org/uniprot/F6XBQ2 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/13616:LOC100010256 ^@ http://purl.uniprot.org/uniprot/F7CA37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMSB10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/13616:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A5F8GF05 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/13616:LOC100618884 ^@ http://purl.uniprot.org/uniprot/F6XZ86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:MRPS5 ^@ http://purl.uniprot.org/uniprot/F6WC63 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/13616:LOC100029406 ^@ http://purl.uniprot.org/uniprot/F7EYD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FAM3B ^@ http://purl.uniprot.org/uniprot/A0A5F8GNJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/13616:DNAJC24 ^@ http://purl.uniprot.org/uniprot/F7BJ34 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/13616:PRL ^@ http://purl.uniprot.org/uniprot/O62819 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the somatotropin/prolactin family.|||Interacts with PRLR.|||Prolactin acts primarily on the mammary gland by promoting lactation.|||Secreted http://togogenome.org/gene/13616:SLC15A2 ^@ http://purl.uniprot.org/uniprot/F6Q744 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/13616:RCAN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8K5|||http://purl.uniprot.org/uniprot/F6VJK2 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/13616:YIPF4 ^@ http://purl.uniprot.org/uniprot/F6WWU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/13616:ATG9B ^@ http://purl.uniprot.org/uniprot/A0A5F8GNS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/13616:CNOT11 ^@ http://purl.uniprot.org/uniprot/F6X050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100023173 ^@ http://purl.uniprot.org/uniprot/F6YL42 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:NLGN1 ^@ http://purl.uniprot.org/uniprot/D2X2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100021121 ^@ http://purl.uniprot.org/uniprot/F7ANK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CAST ^@ http://purl.uniprot.org/uniprot/A0A5F8H065|||http://purl.uniprot.org/uniprot/F7GIJ5 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/13616:LOC100029204 ^@ http://purl.uniprot.org/uniprot/F6XCC1 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/13616:ATE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9F9|||http://purl.uniprot.org/uniprot/A0A5F8GQP8|||http://purl.uniprot.org/uniprot/A0A5F8HAZ4|||http://purl.uniprot.org/uniprot/F7AKZ0 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/13616:LOC100033269 ^@ http://purl.uniprot.org/uniprot/A0A5F8H860 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:LOC100025565 ^@ http://purl.uniprot.org/uniprot/F7FI80 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:DYDC1 ^@ http://purl.uniprot.org/uniprot/F7EMW4 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/13616:SCAMP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4G0|||http://purl.uniprot.org/uniprot/A0A5F8GKC9|||http://purl.uniprot.org/uniprot/A0A5F8HFM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/13616:PDGFRA ^@ http://purl.uniprot.org/uniprot/F7E5I9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/13616:PCMTD2 ^@ http://purl.uniprot.org/uniprot/F6VKL8 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/13616:SLC1A6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9Q7|||http://purl.uniprot.org/uniprot/F7FKW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/13616:CRH ^@ http://purl.uniprot.org/uniprot/F6UTQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/13616:NFIA ^@ http://purl.uniprot.org/uniprot/A0A5F8GRT1|||http://purl.uniprot.org/uniprot/F7BW75 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/13616:KCNK1 ^@ http://purl.uniprot.org/uniprot/F7DH29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Cell membrane|||Cytoplasmic vesicle|||Endosome|||Membrane|||Perikaryon|||Recycling endosome|||Synaptic cell membrane|||Vesicle|||dendrite http://togogenome.org/gene/13616:LOC100024418 ^@ http://purl.uniprot.org/uniprot/F6VJ03 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/13616:LOC100012199 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBC3 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/13616:RBKS ^@ http://purl.uniprot.org/uniprot/F6ZV41 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/13616:RHBDF1 ^@ http://purl.uniprot.org/uniprot/F6YNC9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Regulates ADAM17 protease, a sheddase of the epidermal growth factor (EGF) receptor ligands and TNF, thereby plays a role in sleep, cell survival, proliferation, migration and inflammation. Does not exhibit any protease activity on its own. http://togogenome.org/gene/13616:LOC100030404 ^@ http://purl.uniprot.org/uniprot/F6ZP21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PRIM2 ^@ http://purl.uniprot.org/uniprot/F7FCC2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. http://togogenome.org/gene/13616:LOC103105351 ^@ http://purl.uniprot.org/uniprot/F6VY82 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100020750 ^@ http://purl.uniprot.org/uniprot/F7EXX3 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/13616:HOXD1 ^@ http://purl.uniprot.org/uniprot/F7A8K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/13616:SYNE4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G308 ^@ Similarity ^@ Belongs to the nesprin family. http://togogenome.org/gene/13616:ZCCHC8 ^@ http://purl.uniprot.org/uniprot/F6YGG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC8 family.|||nucleoplasm http://togogenome.org/gene/13616:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/F6XCI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:YDJC ^@ http://purl.uniprot.org/uniprot/F6YJB8 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/13616:A4GNT ^@ http://purl.uniprot.org/uniprot/F7G2J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 32 family.|||Golgi apparatus membrane http://togogenome.org/gene/13616:MOK ^@ http://purl.uniprot.org/uniprot/F7GJG6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:MODO-UE ^@ http://purl.uniprot.org/uniprot/C6ZIV3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:NIF3L1 ^@ http://purl.uniprot.org/uniprot/F7FUK4 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/13616:QPCTL ^@ http://purl.uniprot.org/uniprot/F7DZS6 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/13616:TPX2 ^@ http://purl.uniprot.org/uniprot/F6WA27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/13616:MFNG ^@ http://purl.uniprot.org/uniprot/A0A5F8H3A0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100020485 ^@ http://purl.uniprot.org/uniprot/F7E0N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100021749 ^@ http://purl.uniprot.org/uniprot/F6PZM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GOT2 ^@ http://purl.uniprot.org/uniprot/F6XJK0 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/13616:NDUFAF7 ^@ http://purl.uniprot.org/uniprot/F6ZX82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/13616:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A5F8G9X4|||http://purl.uniprot.org/uniprot/F7BES5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MPDZ. Interacts with ARRB2.|||Membrane http://togogenome.org/gene/13616:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/F6PGG8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/13616:CHAC1 ^@ http://purl.uniprot.org/uniprot/F6TFR6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. ChaC subfamily.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/13616:TMEM70 ^@ http://purl.uniprot.org/uniprot/A0A5F8H858 ^@ Similarity ^@ Belongs to the TMEM70 family. http://togogenome.org/gene/13616:ASF1B ^@ http://purl.uniprot.org/uniprot/F7G4J6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/13616:KCNG3 ^@ http://purl.uniprot.org/uniprot/F6RUG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:IDH2 ^@ http://purl.uniprot.org/uniprot/F6VD67 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/13616:MGAT1 ^@ http://purl.uniprot.org/uniprot/F7EGJ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Initiates complex N-linked carbohydrate formation. Essential for the conversion of high-mannose to hybrid and complex N-glycans.|||Membrane|||The cofactor is mostly bound to the substrate. http://togogenome.org/gene/13616:VN2R594 ^@ http://purl.uniprot.org/uniprot/F7BS98 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:FAM65A ^@ http://purl.uniprot.org/uniprot/F6TL03 ^@ Similarity ^@ Belongs to the RIPOR family. http://togogenome.org/gene/13616:RAD52 ^@ http://purl.uniprot.org/uniprot/F6Q9I8 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/13616:METTL8 ^@ http://purl.uniprot.org/uniprot/A0A5F8G613 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/13616:RDH11 ^@ http://purl.uniprot.org/uniprot/F6US93 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:AARS ^@ http://purl.uniprot.org/uniprot/F7ERQ8 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||ISGylated.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/13616:LOC100031601 ^@ http://purl.uniprot.org/uniprot/F6VB69 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/13616:USP45 ^@ http://purl.uniprot.org/uniprot/F7FFP8 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:DXO ^@ http://purl.uniprot.org/uniprot/F7BXD2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Binds 2 magnesium ions.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/13616:GTF2H1 ^@ http://purl.uniprot.org/uniprot/F7BVJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/13616:MED21 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/13616:TPH1 ^@ http://purl.uniprot.org/uniprot/F7DGX6 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/13616:GRAMD1C ^@ http://purl.uniprot.org/uniprot/F7CCG4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:HDDC2 ^@ http://purl.uniprot.org/uniprot/F7FUJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/13616:LOC100016938 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV92 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:GRN ^@ http://purl.uniprot.org/uniprot/F6QWT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the granulin family.|||Secreted http://togogenome.org/gene/13616:BCL2L10 ^@ http://purl.uniprot.org/uniprot/F6VJQ0 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:LOC100026774 ^@ http://purl.uniprot.org/uniprot/F6SKF7 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/13616:SLC5A11 ^@ http://purl.uniprot.org/uniprot/F7AU44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:PHGDH ^@ http://purl.uniprot.org/uniprot/A0A5F8GBC1|||http://purl.uniprot.org/uniprot/F7FVB4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/13616:MSTO1 ^@ http://purl.uniprot.org/uniprot/F6QEX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:PRRX2 ^@ http://purl.uniprot.org/uniprot/F7BTR9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SNAPC3 ^@ http://purl.uniprot.org/uniprot/F7D0E5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus|||Part of the SNAPc complex composed of 5 subunits: SNAPC1, SNAPC2, SNAPC3, SNAPC4 and SNAPC5. SNAPC3 interacts with SNAPC1.|||Part of the SNAPc complex required for the transcription of both RNA polymerase II and III small-nuclear RNA genes. Binds to the proximal sequence element (PSE), a non-TATA-box basal promoter element common to these 2 types of genes. Recruits TBP and BRF2 to the U6 snRNA TATA box. http://togogenome.org/gene/13616:VN2R570 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA41 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:GNPTAB ^@ http://purl.uniprot.org/uniprot/F6XPQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stealth family.|||Membrane http://togogenome.org/gene/13616:LOC103104413 ^@ http://purl.uniprot.org/uniprot/K7E690 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/13616:NIPAL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ27|||http://purl.uniprot.org/uniprot/F7CDM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/13616:ELP6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXR4 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/13616:LOC100031124 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAU3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100020874 ^@ http://purl.uniprot.org/uniprot/F7FSX2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P2X receptor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/13616:ELP5 ^@ http://purl.uniprot.org/uniprot/F6WSF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LYRM2 ^@ http://purl.uniprot.org/uniprot/F6Q754 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/13616:MMAB ^@ http://purl.uniprot.org/uniprot/F6V9Y7 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/13616:KCNJ5 ^@ http://purl.uniprot.org/uniprot/F6WK38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ5 subfamily.|||Membrane http://togogenome.org/gene/13616:FAM227A ^@ http://purl.uniprot.org/uniprot/F6RRH5 ^@ Similarity ^@ Belongs to the FAM227 family. http://togogenome.org/gene/13616:LOC100018839 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/13616:SLC10A3 ^@ http://purl.uniprot.org/uniprot/F6QFJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/13616:C3H5orf28 ^@ http://purl.uniprot.org/uniprot/F6QB74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NEMF ^@ http://purl.uniprot.org/uniprot/F6XWM2 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/13616:OCLN ^@ http://purl.uniprot.org/uniprot/F6SYJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||May play a role in the formation and regulation of the tight junction (TJ) paracellular permeability barrier.|||Membrane|||tight junction http://togogenome.org/gene/13616:NAXE ^@ http://purl.uniprot.org/uniprot/F7FIH8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. Accelerates cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis (By similarity).|||Homodimer (By similarity). Interacts with APOA1 and APOA2 (By similarity).|||Mitochondrion|||Secreted|||Undergoes physiological phosphorylation during sperm capacitation, downstream to PKA activation. http://togogenome.org/gene/13616:LOC100010772 ^@ http://purl.uniprot.org/uniprot/F7G5N4 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/13616:FGG ^@ http://purl.uniprot.org/uniprot/F7CIN4 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/13616:ETV2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:NPBWR2 ^@ http://purl.uniprot.org/uniprot/F6XHB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:IL1B ^@ http://purl.uniprot.org/uniprot/F6SXC0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||IL1B production occurs in 2 steps, each being controlled by different stimuli. First, inflammatory signals, such as LPS, stimulate the synthesis and promote the accumulation of cytosolic stores of pro-IL1B (priming). Then additional signals are required for inflammasome assembly, leading to CASP1 activation, pro-IL1B processing and eventually secretion of the active cytokine. IL1B processing and secretion are temporarily associated.|||Lysosome|||Monomer. Interacts with MEFV.|||Potent pro-inflammatory cytokine. Initially discovered as the major endogenous pyrogen, induces prostaglandin synthesis, neutrophil influx and activation, T-cell activation and cytokine production, B-cell activation and antibody production, and fibroblast proliferation and collagen production. Promotes Th17 differentiation of T-cells. Synergizes with IL12/interleukin-12 to induce IFNG synthesis from T-helper 1 (Th1) cells. Plays a role in angiogenesis by inducing VEGF production synergistically with TNF and IL6. Involved in transduction of inflammation downstream of pyroptosis: its mature form is specifically released in the extracellular milieu by passing through the gasdermin-D (GSDMD) pore.|||Secreted|||cytosol|||extracellular exosome http://togogenome.org/gene/13616:ZP1 ^@ http://purl.uniprot.org/uniprot/F6WXF3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:OSBP ^@ http://purl.uniprot.org/uniprot/F7G832 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:LOC100018892 ^@ http://purl.uniprot.org/uniprot/K7E3C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100618392 ^@ http://purl.uniprot.org/uniprot/F7EQA7 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:GCLC ^@ http://purl.uniprot.org/uniprot/A0A5F8HLU9|||http://purl.uniprot.org/uniprot/F6ZMX9 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/13616:SNX13 ^@ http://purl.uniprot.org/uniprot/F7APQ1 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:LOC100032661 ^@ http://purl.uniprot.org/uniprot/F7FUJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Component of the DRB sensitivity-inducing factor complex (DSIF complex), which regulates transcription elongation by RNA polymerase II.|||Nucleus http://togogenome.org/gene/13616:SEPT10 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHZ6|||http://purl.uniprot.org/uniprot/F6PI38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Septins polymerize into heterooligomeric protein complexes that form filaments. http://togogenome.org/gene/13616:GATM ^@ http://purl.uniprot.org/uniprot/F6Z4H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the amidinotransferase family.|||Catalyzes the biosynthesis of guanidinoacetate, the immediate precursor of creatine.|||Homodimer.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC103096593 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3R0|||http://purl.uniprot.org/uniprot/A0A5F8H7F0 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:G6PC ^@ http://purl.uniprot.org/uniprot/A0A5F8G347 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:PEX12 ^@ http://purl.uniprot.org/uniprot/F7EUL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Peroxisome membrane|||Required for protein import into peroxisomes. http://togogenome.org/gene/13616:MAN1A2 ^@ http://purl.uniprot.org/uniprot/F7DMZ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:AUH ^@ http://purl.uniprot.org/uniprot/F6QU09 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/13616:NCDN ^@ http://purl.uniprot.org/uniprot/F7F334 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/13616:FPGS ^@ http://purl.uniprot.org/uniprot/A0A5F8H657 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/13616:ALOX12B ^@ http://purl.uniprot.org/uniprot/F7FZA5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GAS6 ^@ http://purl.uniprot.org/uniprot/F7BMD1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:KIFC1 ^@ http://purl.uniprot.org/uniprot/F6XKS9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:LOC100021084 ^@ http://purl.uniprot.org/uniprot/F6RPE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NPPC ^@ http://purl.uniprot.org/uniprot/F7B965 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/13616:ETV7 ^@ http://purl.uniprot.org/uniprot/F7C2W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1255 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN91|||http://purl.uniprot.org/uniprot/F6V7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CCNB1 ^@ http://purl.uniprot.org/uniprot/F6TCH9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/13616:COCH ^@ http://purl.uniprot.org/uniprot/F7BSI0 ^@ Function ^@ Plays a role in the control of cell shape and motility in the trabecular meshwork. http://togogenome.org/gene/13616:monDomV1R1208 ^@ http://purl.uniprot.org/uniprot/A0A5F8G944 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CHRNB1 ^@ http://purl.uniprot.org/uniprot/F6RFH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:FAM129A ^@ http://purl.uniprot.org/uniprot/F7ADC1 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/13616:CFAP97 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEJ1|||http://purl.uniprot.org/uniprot/A0A5F8HC82 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/13616:LEP ^@ http://purl.uniprot.org/uniprot/A0A5F8GBV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the leptin family.|||Key player in the regulation of energy balance and body weight control. Once released into the circulation, has central and peripheral effects by binding LEPR, found in many tissues, which results in the activation of several major signaling pathways. In the hypothalamus, acts as an appetite-regulating factor that induces a decrease in food intake and an increase in energy consumption by inducing anorexinogenic factors and suppressing orexigenic neuropeptides, also regulates bone mass and secretion of hypothalamo-pituitary-adrenal hormones. In the periphery, increases basal metabolism, influences reproductive function, regulates pancreatic beta-cell function and insulin secretion, is pro-angiogenic for endothelial cell and affects innate and adaptive immunity. In the arcuate nucleus of the hypothalamus, activates by depolarization POMC neurons inducing FOS and SOCS3 expression to release anorexigenic peptides and inhibits by hyperpolarization NPY neurons inducing SOCS3 with a consequent reduction on release of orexigenic peptides. In addition to its known satiety inducing effect, has a modulatory role in nutrient absorption. In the intestine, reduces glucose absorption by enterocytes by activating PKC and leading to a sequential activation of p38, PI3K and ERK signaling pathways which exerts an inhibitory effect on glucose absorption. Acts as a growth factor on certain tissues, through the activation of different signaling pathways increases expression of genes involved in cell cycle regulation such as CCND1, via JAK2-STAT3 pathway, or VEGFA, via MAPK1/3 and PI3K-AKT1 pathways. May also play an apoptotic role via JAK2-STAT3 pathway and up-regulation of BIRC5 expression. Pro-angiogenic, has mitogenic activity on vascular endothelial cells and plays a role in matrix remodeling by regulating the expression of matrix metalloproteinases (MMPs) and tissue inhibitors of metalloproteinases (TIMPs). In innate immunity, modulates the activity and function of neutrophils by increasing chemotaxis and the secretion of oxygen radicals. Increases phagocytosis by macrophages and enhances secretion of pro-inflammatory mediators. Increases cytotoxic ability of NK cells. Plays a pro-inflammatory role, in synergy with IL1B, by inducing NOS2 wich promotes the production of IL6, IL8 and Prostaglandin E2, through a signaling pathway that involves JAK2, PI3K, MAP2K1/MEK1 and MAPK14/p38. In adaptive immunity, promotes the switch of memory T-cells towards T helper-1 cell immune responses. Increases CD4(+)CD25(-) T-cell proliferation and reduces autophagy during TCR (T-cell receptor) stimulation, through MTOR signaling pathway activation and BCL2 up-regulation.|||Secreted http://togogenome.org/gene/13616:SCNM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G956|||http://purl.uniprot.org/uniprot/A0A5F8HJX6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus speckle|||Plays a role in alternative splicing of pre-mRNAs, possibly by contributing to the selection of non-consensus donor sites.|||nucleoplasm http://togogenome.org/gene/13616:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A5F8H619 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/13616:LOC100009995 ^@ http://purl.uniprot.org/uniprot/F6QZ90 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:GADD45A ^@ http://purl.uniprot.org/uniprot/F6SSE6 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/13616:ELMO2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6Y5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/13616:STIM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHF9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:TNR ^@ http://purl.uniprot.org/uniprot/F7BXQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/13616:PNPT1 ^@ http://purl.uniprot.org/uniprot/F6RID9 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/13616:LOC100017048 ^@ http://purl.uniprot.org/uniprot/F7FJK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Secreted http://togogenome.org/gene/13616:GAS8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H576|||http://purl.uniprot.org/uniprot/A0A5F8HET4|||http://purl.uniprot.org/uniprot/F7EG11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum axoneme http://togogenome.org/gene/13616:DARS2 ^@ http://purl.uniprot.org/uniprot/F6Y9Y7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/13616:KCNV1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5X7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/13616:LOC100030489 ^@ http://purl.uniprot.org/uniprot/F7AGA4 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6c family. http://togogenome.org/gene/13616:TRPC4 ^@ http://purl.uniprot.org/uniprot/F6TA59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PPP2R5D ^@ http://purl.uniprot.org/uniprot/F7C5Z9 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/13616:LOC100026112 ^@ http://purl.uniprot.org/uniprot/F7DNL5 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/13616:DNM1L ^@ http://purl.uniprot.org/uniprot/A0A5F8HCP4|||http://purl.uniprot.org/uniprot/F6WIN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||Endomembrane system|||Golgi apparatus|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||clathrin-coated pit|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/13616:SRD5A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8A2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Also able to convert testosterone (T) into 5-alpha-dihydrotestosterone (DHT).|||Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/13616:GTF2A2 ^@ http://purl.uniprot.org/uniprot/F6TJT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/13616:KCNJ3 ^@ http://purl.uniprot.org/uniprot/F6UBI7|||http://purl.uniprot.org/uniprot/F6YV60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with GIRK2, GIRK3 or GIRK4 to form a G-protein activated heteromultimer pore-forming unit. The resulting inward current is much larger.|||Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ3 subfamily.|||Membrane|||This potassium channel is controlled by G proteins. Inward rectifier potassium channels are characterized by a greater tendency to allow potassium to flow into the cell rather than out of it. Their voltage dependence is regulated by the concentration of extracellular potassium; as external potassium is raised, the voltage range of the channel opening shifts to more positive voltages. The inward rectification is mainly due to the blockage of outward current by internal magnesium. This receptor plays a crucial role in regulating the heartbeat. http://togogenome.org/gene/13616:RSG1 ^@ http://purl.uniprot.org/uniprot/F6THU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Potential effector of the planar cell polarity signaling pathway. Plays a role in targeted membrane trafficking most probably at the level of vesicle fusion with membranes. Involved in cilium biogenesis by regulating the transport of cargo proteins to the basal body and to the apical tips of cilia. More generally involved in exocytosis in secretory cells.|||cilium basal body http://togogenome.org/gene/13616:ZDHHC24 ^@ http://purl.uniprot.org/uniprot/F7E5D5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKA8|||http://purl.uniprot.org/uniprot/A0A5F8GY41|||http://purl.uniprot.org/uniprot/A0A5F8HA32|||http://purl.uniprot.org/uniprot/F6VRF8 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/13616:SESN2 ^@ http://purl.uniprot.org/uniprot/F7ARK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/13616:FAM72A ^@ http://purl.uniprot.org/uniprot/F6RIT0 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/13616:CPZ ^@ http://purl.uniprot.org/uniprot/A0A5F8HL88|||http://purl.uniprot.org/uniprot/F6TZK5 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TP53RK ^@ http://purl.uniprot.org/uniprot/K7DZC6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/13616:LTC4S ^@ http://purl.uniprot.org/uniprot/F7EVP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:AOX4 ^@ http://purl.uniprot.org/uniprot/M1ZMS0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/13616:YIPF3 ^@ http://purl.uniprot.org/uniprot/F7G044 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Cell membrane|||Cytoplasm|||Involved in the maintenance of the Golgi structure. May play a role in hematopoiesis.|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:GPLD1 ^@ http://purl.uniprot.org/uniprot/F6UZA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/13616:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NRDE2 ^@ http://purl.uniprot.org/uniprot/F7CXT9 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/13616:SLC8A2 ^@ http://purl.uniprot.org/uniprot/F6VFC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:IQCG ^@ http://purl.uniprot.org/uniprot/F6QUC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/13616:CPB1 ^@ http://purl.uniprot.org/uniprot/F6TIT0 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFF1|||http://purl.uniprot.org/uniprot/F6RLV5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:GPD2 ^@ http://purl.uniprot.org/uniprot/F6X5V3 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/13616:LOC100018857 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:BCAP31 ^@ http://purl.uniprot.org/uniprot/A0A5F8G548 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a role in the export of secreted proteins in the ER. http://togogenome.org/gene/13616:LOC100023848 ^@ http://purl.uniprot.org/uniprot/F6Q1P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TBC1D23 ^@ http://purl.uniprot.org/uniprot/A0A5F8H472|||http://purl.uniprot.org/uniprot/F7DG20 ^@ Subcellular Location Annotation ^@ trans-Golgi network http://togogenome.org/gene/13616:KCNMB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN68 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/13616:VN2R516 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCZ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PAPOLG ^@ http://purl.uniprot.org/uniprot/A0A5F8G3M1|||http://purl.uniprot.org/uniprot/F6YET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/13616:MAX ^@ http://purl.uniprot.org/uniprot/A0A5F8G728|||http://purl.uniprot.org/uniprot/A0A5F8GK25|||http://purl.uniprot.org/uniprot/A0A5F8HCQ6 ^@ Similarity ^@ Belongs to the MAX family. http://togogenome.org/gene/13616:RNASEH1 ^@ http://purl.uniprot.org/uniprot/F7FKT3 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/13616:CBLB ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Q1|||http://purl.uniprot.org/uniprot/F6T5M5 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from specific E2 ubiquitin-conjugating enzymes, and transfers it to substrates, generally promoting their degradation by the proteasome.|||The N-terminus is composed of the phosphotyrosine binding (PTB) domain, a short linker region and the RING-type zinc finger. The PTB domain, which is also called TKB (tyrosine kinase binding) domain, is composed of three different subdomains: a four-helix bundle (4H), a calcium-binding EF hand and a divergent SH2 domain. http://togogenome.org/gene/13616:VPS26B ^@ http://purl.uniprot.org/uniprot/F7FVE6 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/13616:TMEM159 ^@ http://purl.uniprot.org/uniprot/F6WTF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/13616:LOC100031295 ^@ http://purl.uniprot.org/uniprot/F6UH76 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:S100A1 ^@ http://purl.uniprot.org/uniprot/F6VYT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Mitochondrion http://togogenome.org/gene/13616:GRB14 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9F8|||http://purl.uniprot.org/uniprot/F6XXY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/13616:DHTKD1 ^@ http://purl.uniprot.org/uniprot/F7FVJ6 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/13616:OTUD7B ^@ http://purl.uniprot.org/uniprot/F7AE38 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SLC29A4 ^@ http://purl.uniprot.org/uniprot/F7ESE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/13616:KCNV2 ^@ http://purl.uniprot.org/uniprot/F7BMH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100021392 ^@ http://purl.uniprot.org/uniprot/F6ZZ56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PROC ^@ http://purl.uniprot.org/uniprot/F7AEE9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:SPOCK3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HID6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NSUN5 ^@ http://purl.uniprot.org/uniprot/F6WS57 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/13616:GIPR ^@ http://purl.uniprot.org/uniprot/F6WUD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RND3 ^@ http://purl.uniprot.org/uniprot/F6RYV4 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/13616:SLC2A12 ^@ http://purl.uniprot.org/uniprot/F7F0U7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/13616:LOC100011551 ^@ http://purl.uniprot.org/uniprot/K7DZE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/13616:AGO2 ^@ http://purl.uniprot.org/uniprot/F6VPM9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Hydroxylated. 4-hydroxylation appears to enhance protein stability but is not required for miRNA-binding or endonuclease activity.|||Interacts with DICER1 through its Piwi domain and with TARBP2 during assembly of the RNA-induced silencing complex (RISC). Together, DICER1, AGO2 and TARBP2 constitute the trimeric RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC). Within the RLC/miRLC, DICER1 and TARBP2 are required to process precursor miRNAs (pre-miRNAs) to mature miRNAs and then load them onto AGO2. AGO2 bound to the mature miRNA constitutes the minimal RISC and may subsequently dissociate from DICER1 and TARBP2. Note however that the term RISC has also been used to describe the trimeric RLC/miRLC. The formation of RISC complexes containing siRNAs rather than miRNAs appears to occur independently of DICER1. Interacts with AGO1. Also interacts with DDB1, DDX5, DDX6, DDX20, DHX30, DHX36, DDX47, DHX9, ELAVL, FXR1, GEMIN4, HNRNPF, IGF2BP1, ILF3, IMP8, MATR3, PABPC1, PRMT5, P4HA1, P4HB, RBM4, SART3, TNRC6A, TNRC6B, UPF1 and YBX1. Interacts with the P-body components DCP1A and XRN1. Associates with polysomes and messenger ribonucleoproteins (mNRPs). Interacts with RBM4; the interaction is modulated under stress-induced conditions, occurs under both cell proliferation and differentiation conditions and in an RNA-and phosphorylation-independent manner. Interacts with LIMD1, WTIP and AJUBA. Interacts with TRIM71. Interacts with APOBEC3G in an RNA-dependent manner. Interacts with APOBEC3A, APOBEC3C, APOBEC3F and APOBEC3H. Interacts with DICER1, TARBP2, EIF6, MOV10 and RPL7A (60S ribosome subunit); they form a large RNA-induced silencing complex (RISC). Interacts with FMR1. Interacts with ZFP36.|||Nucleus|||P-body|||Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include AGO2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by AGO2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. May inhibit translation initiation by binding to the 7-methylguanosine cap, thereby preventing the recruitment of the translation initiation factor eIF4-E. May also inhibit translation initiation via interaction with EIF6, which itself binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur. In some cases RISC-mediated translational repression is also observed for miRNAs that perfectly match the 3' untranslated region (3'-UTR). Can also up-regulate the translation of specific mRNAs under certain growth conditions. Binds to the AU element of the 3'-UTR of the TNF (TNF-alpha) mRNA and up-regulates translation under conditions of serum starvation. Also required for transcriptional gene silencing (TGS), in which short RNAs known as antigene RNAs or agRNAs direct the transcriptional repression of complementary promoter regions.|||The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH). http://togogenome.org/gene/13616:OPALIN ^@ http://purl.uniprot.org/uniprot/F6T2B6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Central nervous system-specific myelin protein that increase myelin genes expression during oligodendrocyte differentiation. Promotes oligodendrocyte terminal differentiation.|||Membrane http://togogenome.org/gene/13616:LOC100022164 ^@ http://purl.uniprot.org/uniprot/F7BDE2 ^@ Function|||Similarity ^@ Belongs to the GST superfamily. Omega family.|||Exhibits glutathione-dependent thiol transferase activity. Has high dehydroascorbate reductase activity and may contribute to the recycling of ascorbic acid. Participates in the biotransformation of inorganic arsenic and reduces monomethylarsonic acid (MMA). http://togogenome.org/gene/13616:FAM129C ^@ http://purl.uniprot.org/uniprot/F6SVS0 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/13616:LOC100017849 ^@ http://purl.uniprot.org/uniprot/F7ARZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RNF20 ^@ http://purl.uniprot.org/uniprot/F7AUI3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/13616:LOC100023762 ^@ http://purl.uniprot.org/uniprot/F6ZH50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ZBED4 ^@ http://purl.uniprot.org/uniprot/F6VLV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAAH2 ^@ http://purl.uniprot.org/uniprot/F7F0S7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/13616:CLPTM1L ^@ http://purl.uniprot.org/uniprot/F7EAA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/13616:NACC1 ^@ http://purl.uniprot.org/uniprot/F6U150 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CNOT6 ^@ http://purl.uniprot.org/uniprot/F7F909 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MCHR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBM5 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/13616:SLC9A3R1 ^@ http://purl.uniprot.org/uniprot/F6Q7D5 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression.|||filopodium|||microvillus|||ruffle http://togogenome.org/gene/13616:NTNG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKK9|||http://purl.uniprot.org/uniprot/F6Q0S1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:monDomV1R1211 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PPP6C ^@ http://purl.uniprot.org/uniprot/A0A5F8HHF5 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/13616:WRB ^@ http://purl.uniprot.org/uniprot/A0A5F8GGM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WRB/GET1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:NME1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG11|||http://purl.uniprot.org/uniprot/A0A5F8GM45|||http://purl.uniprot.org/uniprot/F6PIN1 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/13616:PROK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AVIT (prokineticin) family.|||Secreted http://togogenome.org/gene/13616:TIMM8B ^@ http://purl.uniprot.org/uniprot/F6T6S9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. http://togogenome.org/gene/13616:TANGO6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJE4 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/13616:AGBL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD42|||http://purl.uniprot.org/uniprot/F6VP01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/13616:EREG ^@ http://purl.uniprot.org/uniprot/F7A8Z0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GAD1 ^@ http://purl.uniprot.org/uniprot/F7DHD9 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:SPTB ^@ http://purl.uniprot.org/uniprot/F6Q881 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/13616:IVD ^@ http://purl.uniprot.org/uniprot/F6VDN3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:OXTR ^@ http://purl.uniprot.org/uniprot/F6U716 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Membrane|||Receptor for oxytocin. The activity of this receptor is mediated by G proteins which activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/13616:LOC103092827 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane http://togogenome.org/gene/13616:KAT2B ^@ http://purl.uniprot.org/uniprot/F7A3N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Nucleus|||centrosome http://togogenome.org/gene/13616:SLC39A6 ^@ http://purl.uniprot.org/uniprot/F6UAP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DDX11 ^@ http://purl.uniprot.org/uniprot/F6RFQ7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. http://togogenome.org/gene/13616:PIM2 ^@ http://purl.uniprot.org/uniprot/F6TUF2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:ENAH ^@ http://purl.uniprot.org/uniprot/A0A5F8GGR9|||http://purl.uniprot.org/uniprot/F7FCN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||cytoskeleton http://togogenome.org/gene/13616:LOC100018877 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100013147 ^@ http://purl.uniprot.org/uniprot/F7C2A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100023655 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPP0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/13616:PEX1 ^@ http://purl.uniprot.org/uniprot/F7G7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/13616:SH3KBP1 ^@ http://purl.uniprot.org/uniprot/F7DH99 ^@ Subcellular Location Annotation ^@ focal adhesion http://togogenome.org/gene/13616:DNPH1 ^@ http://purl.uniprot.org/uniprot/F7FPA3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2'-deoxynucleoside 5'-phosphate N-hydrolase 1 family.|||Catalyzes the cleavage of the N-glycosidic bond of deoxyribonucleoside 5'-monophosphates to yield deoxyribose 5-phosphate and a purine or pyrimidine base. Deoxyribonucleoside 5'-monophosphates containing purine bases are preferred to those containing pyrimidine bases.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer and homodimer.|||Nucleus http://togogenome.org/gene/13616:PGC ^@ http://purl.uniprot.org/uniprot/Q689Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Hydrolyzes various peptides including beta-endorphin, insulin B chain, dynorphin A, and neurokinin A, with high specificity for the cleavage of the Phe-Xaa bonds.|||Secreted http://togogenome.org/gene/13616:ACKR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Atypical chemokine receptor that controls chemokine levels and localization via high-affinity chemokine binding that is uncoupled from classic ligand-driven signal transduction cascades, resulting instead in chemokine sequestration, degradation, or transcytosis. Also known as interceptor (internalizing receptor) or chemokine-scavenging receptor or chemokine decoy receptor. Has a promiscuous chemokine-binding profile, interacting with inflammatory chemokines of both the CXC and the CC subfamilies but not with homeostatic chemokines. Acts as a receptor for chemokines including CCL2, CCL5, CCL7, CCL11, CCL13, CCL14, CCL17, CXCL5, CXCL6, IL8/CXCL8, CXCL11, GRO, RANTES, MCP-1 and TARC. May regulate chemokine bioavailability and, consequently, leukocyte recruitment through two distinct mechanisms: when expressed in endothelial cells, it sustains the abluminal to luminal transcytosis of tissue-derived chemokines and their subsequent presentation to circulating leukocytes; when expressed in erythrocytes, serves as blood reservoir of cognate chemokines but also as a chemokine sink, buffering potential surges in plasma chemokine levels.|||Belongs to the G-protein coupled receptor 1 family. Atypical chemokine receptor subfamily.|||Early endosome|||Membrane|||Recycling endosome http://togogenome.org/gene/13616:LOC100021064 ^@ http://purl.uniprot.org/uniprot/F7CGM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:PDSS1 ^@ http://purl.uniprot.org/uniprot/F7DHD1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/13616:SNAP23 ^@ http://purl.uniprot.org/uniprot/F7FGR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/13616:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A5F8GC35 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/13616:PNRC2 ^@ http://purl.uniprot.org/uniprot/F7C7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNRC family. PNRC2 subfamily.|||Nucleus|||P-body http://togogenome.org/gene/13616:LOC100022478 ^@ http://purl.uniprot.org/uniprot/F7BRM4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/13616:SNAPIN ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Y7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPIN family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking and synaptic vesicle recycling.|||synaptic vesicle membrane http://togogenome.org/gene/13616:CSF3 ^@ http://purl.uniprot.org/uniprot/F7CRM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Granulocyte/macrophage colony-stimulating factors are cytokines that act in hematopoiesis by controlling the production, differentiation, and function of 2 related white cell populations of the blood, the granulocytes and the monocytes-macrophages. This CSF induces granulocytes.|||Secreted http://togogenome.org/gene/13616:CXCL13 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/13616:GCNT7 ^@ http://purl.uniprot.org/uniprot/F7A4Z1 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100023527 ^@ http://purl.uniprot.org/uniprot/F7FMD0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:SLC25A46 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUW1|||http://purl.uniprot.org/uniprot/F7F157 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:LOC100021368 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:VTI1A ^@ http://purl.uniprot.org/uniprot/F6TAL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/13616:GLP1R ^@ http://purl.uniprot.org/uniprot/F6ZL39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TAS2R60 ^@ http://purl.uniprot.org/uniprot/Q2AB85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:CRKL ^@ http://purl.uniprot.org/uniprot/F6Z4K4 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/13616:LOC103092765 ^@ http://purl.uniprot.org/uniprot/F7DWH6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/F7EDC7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:LOC100030075 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NPEPPS ^@ http://purl.uniprot.org/uniprot/F6PLN8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:PIN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMX7 ^@ Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily. http://togogenome.org/gene/13616:NUP85 ^@ http://purl.uniprot.org/uniprot/F6VWW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/13616:PLK4 ^@ http://purl.uniprot.org/uniprot/F6YGH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Cleavage furrow|||centriole http://togogenome.org/gene/13616:AVL9 ^@ http://purl.uniprot.org/uniprot/F7DF01 ^@ Subcellular Location Annotation ^@ Endosome|||Recycling endosome http://togogenome.org/gene/13616:LOC100019084 ^@ http://purl.uniprot.org/uniprot/F7FQM8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TGS1 ^@ http://purl.uniprot.org/uniprot/F7ADF5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/13616:FZD3 ^@ http://purl.uniprot.org/uniprot/F6PWM3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:PKNOX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3S9|||http://purl.uniprot.org/uniprot/F7D6U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/13616:LOC103099758 ^@ http://purl.uniprot.org/uniprot/F7GEF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SNX30 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU33 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:PEX13 ^@ http://purl.uniprot.org/uniprot/F7DG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/13616:DNTT ^@ http://purl.uniprot.org/uniprot/O02789 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-X family.|||Can also utilize other divalent cations, such as Mn(2+) and Co(2+) (in vitro).|||Interacts with PRP19 and DNTTIP1. Interacts with TRERF1. Forms a ternary complex with DNTTIP2 and core histone. Released from this complex by PCNA (By similarity).|||Nucleus|||Template-independent DNA polymerase which catalyzes the random addition of deoxynucleoside 5'-triphosphate to the 3'-end of a DNA initiator. One of the in vivo functions of this enzyme is the addition of nucleotides at the junction (N region) of rearranged Ig heavy chain and T-cell receptor gene segments during the maturation of B- and T-cells. http://togogenome.org/gene/13616:LOC100022472 ^@ http://purl.uniprot.org/uniprot/F7CU36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100029345 ^@ http://purl.uniprot.org/uniprot/A0A5F8H096 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/13616:STARD6 ^@ http://purl.uniprot.org/uniprot/F7EML9 ^@ Function ^@ May be involved in the intracellular transport of sterols or other lipids. May bind cholesterol or other sterols. http://togogenome.org/gene/13616:SERPINH1 ^@ http://purl.uniprot.org/uniprot/F6PGJ9 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/13616:GUF1 ^@ http://purl.uniprot.org/uniprot/F7A0N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/13616:BDKRB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7W0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/13616:LOC100022049 ^@ http://purl.uniprot.org/uniprot/F6W8M3 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/13616:monDomV1R1267 ^@ http://purl.uniprot.org/uniprot/F6V7E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PPARA ^@ http://purl.uniprot.org/uniprot/F7ADB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Ligand-activated transcription factor. Key regulator of lipid metabolism. Activated by the endogenous ligand 1-palmitoyl-2-oleoyl-sn-glycerol-3-phosphocholine (16:0/18:1-GPC). Activated by oleylethanolamide, a naturally occurring lipid that regulates satiety. Receptor for peroxisome proliferators such as hypolipidemic drugs and fatty acids. Regulates the peroxisomal beta-oxidation pathway of fatty acids. Functions as transcription activator for the ACOX1 and P450 genes. Transactivation activity requires heterodimerization with RXRA and is antagonized by NR2C2. May be required for the propagation of clock information to metabolic pathways regulated by PER2.|||Nucleus http://togogenome.org/gene/13616:WDR48 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Endosome|||Late endosome http://togogenome.org/gene/13616:POP7 ^@ http://purl.uniprot.org/uniprot/F6R4U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone-like Alba family.|||Component of nuclear RNase P and RNase MRP complexes. RNase P consists of a catalytic RNA moiety and 10 different protein chains; POP1, POP4, POP5, POP7, RPP14, RPP21, RPP25, RPP30, RPP38 and RPP40. Within the RNase P complex, POP1, POP7 and RPP25 form the 'finger' subcomplex, POP5, RPP14, RPP40 and homodimeric RPP30 form the 'palm' subcomplex, and RPP21, POP4 and RPP38 form the 'wrist' subcomplex. All subunits of the RNase P complex interact with the catalytic RNA. Several subunits of RNase P are also part of the RNase MRP complex. RNase MRP consists of a catalytic RNA moiety and about 8 protein subunits; POP1, POP7, RPP25, RPP30, RPP38, RPP40 and possibly also POP4 and POP5. Interacts with SMN1. POP7 forms a heterodimer with RPP25 that binds to the P3 stem loop of the catalytic RNA.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends. Also a component of the MRP ribonuclease complex, which cleaves pre-rRNA sequences.|||Cytoplasmic granule|||nucleolus http://togogenome.org/gene/13616:MSX2 ^@ http://purl.uniprot.org/uniprot/F6WWM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RPAP1 ^@ http://purl.uniprot.org/uniprot/F6YC25 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/13616:COL4A3BP ^@ http://purl.uniprot.org/uniprot/A0A5F8GSL3|||http://purl.uniprot.org/uniprot/A0A5F8H2W9|||http://purl.uniprot.org/uniprot/F6UGQ8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/13616:PIGV ^@ http://purl.uniprot.org/uniprot/F6SRF8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/13616:NOL10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/13616:LOC100023218 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PTPRK ^@ http://purl.uniprot.org/uniprot/A0A5F8GSG5|||http://purl.uniprot.org/uniprot/F6YJV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/13616:B4GALNT2 ^@ http://purl.uniprot.org/uniprot/F6YH79|||http://purl.uniprot.org/uniprot/K7E359 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Membrane http://togogenome.org/gene/13616:GON4L ^@ http://purl.uniprot.org/uniprot/F6QF38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMEM50A ^@ http://purl.uniprot.org/uniprot/A0A5F8HDH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/13616:SIAH1 ^@ http://purl.uniprot.org/uniprot/F7DC68 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/13616:LOC100013048 ^@ http://purl.uniprot.org/uniprot/F7F0U2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:TMPRSS11D ^@ http://purl.uniprot.org/uniprot/F7A010 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HEXB ^@ http://purl.uniprot.org/uniprot/F6S6D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/13616:CDKN1A ^@ http://purl.uniprot.org/uniprot/F7D6Q4 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/13616:GPN3 ^@ http://purl.uniprot.org/uniprot/F6UGC0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/13616:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GED8|||http://purl.uniprot.org/uniprot/F7D7N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/13616:GDI2 ^@ http://purl.uniprot.org/uniprot/F7B3M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/13616:TARSL2 ^@ http://purl.uniprot.org/uniprot/F7DDV7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:PTCH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXF9|||http://purl.uniprot.org/uniprot/F6YGY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/13616:PNO1 ^@ http://purl.uniprot.org/uniprot/F7G112 ^@ Similarity ^@ Belongs to the PNO1 family. http://togogenome.org/gene/13616:LOC100027243 ^@ http://purl.uniprot.org/uniprot/F7CWI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/13616:ADRA2B ^@ http://purl.uniprot.org/uniprot/F7G5U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family. Adrenergic receptor subfamily. ADRA2B sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TBPL2 ^@ http://purl.uniprot.org/uniprot/F7GB53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/13616:LOC100019585 ^@ http://purl.uniprot.org/uniprot/F7EEE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRIAP1 ^@ http://purl.uniprot.org/uniprot/F6WE13 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/13616:SET ^@ http://purl.uniprot.org/uniprot/F7AFN2 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/13616:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHN5|||http://purl.uniprot.org/uniprot/A0A5F8GUV3|||http://purl.uniprot.org/uniprot/F7F7Y5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:FBXO31 ^@ http://purl.uniprot.org/uniprot/A0A5F8G954|||http://purl.uniprot.org/uniprot/A0A5F8GEG3|||http://purl.uniprot.org/uniprot/F6V9B7 ^@ Similarity|||Subunit ^@ Belongs to the FBXO31 family.|||Part of a SCF (SKP1-cullin-F-box) protein ligase complex. http://togogenome.org/gene/13616:GRM3 ^@ http://purl.uniprot.org/uniprot/F6V5G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/13616:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMB0|||http://purl.uniprot.org/uniprot/F6R2R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/13616:PSMC4 ^@ http://purl.uniprot.org/uniprot/F6Y9A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMC4 belongs to the heterohexameric ring of AAA (ATPases associated with diverse cellular activities) proteins that unfolds ubiquitinated target proteins that are concurrently translocated into a proteolytic chamber and degraded into peptides.|||Cytoplasm http://togogenome.org/gene/13616:EDNRB ^@ http://purl.uniprot.org/uniprot/F7F4F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KPNA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEX0|||http://purl.uniprot.org/uniprot/F6ZXA8 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:LOC100025159 ^@ http://purl.uniprot.org/uniprot/F6UKU7 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/13616:GALNT14 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTV4|||http://purl.uniprot.org/uniprot/F6VYP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:ITGA4 ^@ http://purl.uniprot.org/uniprot/F6R3Z0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100017736 ^@ http://purl.uniprot.org/uniprot/F6TI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100024446 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFR1|||http://purl.uniprot.org/uniprot/F7AYT6 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/13616:PPIP5K2 ^@ http://purl.uniprot.org/uniprot/F6RZB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/13616:LOC100015106 ^@ http://purl.uniprot.org/uniprot/F6SRQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EVX1 ^@ http://purl.uniprot.org/uniprot/F6USZ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100017292 ^@ http://purl.uniprot.org/uniprot/F6TBS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:T2R7A ^@ http://purl.uniprot.org/uniprot/Q2ABA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:ALKBH8 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/13616:MMAA ^@ http://purl.uniprot.org/uniprot/F6Y622 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/13616:ABHD2 ^@ http://purl.uniprot.org/uniprot/F6R853 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/13616:TBC1D7 ^@ http://purl.uniprot.org/uniprot/F7DPC6 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/13616:NAPEPLD ^@ http://purl.uniprot.org/uniprot/F6WYD3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAPE-PLD family.|||Binds 2 zinc divalent cations per subunit.|||Homodimer. Bile acids promote the assembly of inactive monomers into an active dimer and enable catalysis.|||Nucleus envelope http://togogenome.org/gene/13616:EIF4H ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Y9 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/13616:NXF1 ^@ http://purl.uniprot.org/uniprot/F6YJ26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NXF family.|||Cytoplasm|||nucleoplasm http://togogenome.org/gene/13616:SNX21 ^@ http://purl.uniprot.org/uniprot/F6ST07 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:CLDN11 ^@ http://purl.uniprot.org/uniprot/F7GIS3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:LOC100015820 ^@ http://purl.uniprot.org/uniprot/F6V2C5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/13616:PDS5A ^@ http://purl.uniprot.org/uniprot/F7AQ10 ^@ Similarity ^@ Belongs to the PDS5 family. http://togogenome.org/gene/13616:LOC100013946 ^@ http://purl.uniprot.org/uniprot/F7D009 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/13616:GTPBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G323|||http://purl.uniprot.org/uniprot/F6RR07 ^@ Function ^@ Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity. http://togogenome.org/gene/13616:VN2R544 ^@ http://purl.uniprot.org/uniprot/F7C9N7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:OLFM4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6X6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SLC39A12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNW9|||http://purl.uniprot.org/uniprot/F6QTS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/13616:HPSE ^@ http://purl.uniprot.org/uniprot/F6RYL5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/13616:KDM5A ^@ http://purl.uniprot.org/uniprot/A0A5F8HAH0|||http://purl.uniprot.org/uniprot/F6QU82 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/13616:KCNT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKY4|||http://purl.uniprot.org/uniprot/F6YGT3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CCNH ^@ http://purl.uniprot.org/uniprot/A0A5F8G4C0 ^@ Function|||Similarity|||Subunit ^@ Associates primarily with CDK7 and MAT1 to form the CAK complex. CAK can further associate with the core-TFIIH to form the TFIIH basal transcription factor.|||Belongs to the cyclin family.|||Regulates CDK7, the catalytic subunit of the CDK-activating kinase (CAK) enzymatic complex. CAK activates the cyclin-associated kinases CDK1, CDK2, CDK4 and CDK6 by threonine phosphorylation. CAK complexed to the core-TFIIH basal transcription factor activates RNA polymerase II by serine phosphorylation of the repetitive C-terminal domain (CTD) of its large subunit (POLR2A), allowing its escape from the promoter and elongation of the transcripts. Involved in cell cycle control and in RNA transcription by RNA polymerase II. Its expression and activity are constant throughout the cell cycle. http://togogenome.org/gene/13616:VN2R650 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAF0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CYSTM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/13616:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/A0A5F8H9I1|||http://purl.uniprot.org/uniprot/F6Z8A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/13616:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A5F8G986 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrial transporter required for glutathione import into mitochondria. Glutathione, which plays key roles in oxidative metabolism, is produced exclusively in the cytosol and is imported in many organelles. Mitochondrial glutathione is required for the activity and stability of proteins containing iron-sulfur clusters, as well as erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100019935 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK22 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/13616:LOC100020486 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8W5|||http://purl.uniprot.org/uniprot/F6ZXR8 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/13616:LOC100025071 ^@ http://purl.uniprot.org/uniprot/F7GI68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LTB ^@ http://purl.uniprot.org/uniprot/F6Z4T6 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/13616:CDH9 ^@ http://purl.uniprot.org/uniprot/F6UBJ7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TEAD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Y2|||http://purl.uniprot.org/uniprot/A0A5F8G6L0|||http://purl.uniprot.org/uniprot/A0A5F8GT60|||http://purl.uniprot.org/uniprot/F7F1L8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GRPR ^@ http://purl.uniprot.org/uniprot/F6XXP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RHOT2 ^@ http://purl.uniprot.org/uniprot/F7BZ68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:ME3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP42 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/13616:SPDL1 ^@ http://purl.uniprot.org/uniprot/F6UEJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Spindly family.|||Interacts with KNTC1 and ZW10. These interactions appear weak and may be transient or indirect.|||Nucleus|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex. Also required for correct spindle orientation. Does not appear to be required for the removal of spindle assembly checkpoint (SAC) proteins from the kinetochore upon bipolar spindle attachment.|||centrosome|||kinetochore|||spindle pole http://togogenome.org/gene/13616:FZD2 ^@ http://purl.uniprot.org/uniprot/F6RKF7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:FBXO34 ^@ http://purl.uniprot.org/uniprot/A0A5F8G972 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/13616:ATP2C2 ^@ http://purl.uniprot.org/uniprot/F6ULX9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:EBP ^@ http://purl.uniprot.org/uniprot/F6W675 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:VN2R563 ^@ http://purl.uniprot.org/uniprot/A0A5F8H813 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CLDN25 ^@ http://purl.uniprot.org/uniprot/F6U6S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:monDomV1R1238 ^@ http://purl.uniprot.org/uniprot/A0A5F8H815 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SMPDL3A ^@ http://purl.uniprot.org/uniprot/F7EL84 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Binds 2 Zn(2+) per subunit.|||Secreted http://togogenome.org/gene/13616:PRRX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GML0|||http://purl.uniprot.org/uniprot/F7FQ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/13616:ENY2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG68|||http://purl.uniprot.org/uniprot/A0A5F8GYR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least ENY2, GANP, PCID2, DSS1, and either centrin CETN2 or CETN3. TREX-2 contains 2 ENY2 chains. The TREX-2 complex interacts with the nucleoporin NUP153. Component of some SAGA transcription coactivator-HAT complexes, at least composed of ATXN7, ATXN7L3, ENY2, GCN5L2, SUPT3H, TAF10, TRRAP and USP22. Within the SAGA complex, ENY2, ATXN7, ATXN7L3, and USP22 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with ATXN7L3, GANP and with the RNA polymerase II. Interacts strongly with ATXN7L3 and ATXN7L3B.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates both histones H2A and H2B. The SAGA complex is recruited to specific gene promoters by activators such as MYC, where it is required for transcription. Required for nuclear receptor-mediated transactivation. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/13616:LOC100027100 ^@ http://purl.uniprot.org/uniprot/F6UKW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TTR ^@ http://purl.uniprot.org/uniprot/P49141 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Belongs to the transthyretin family.|||Detected in plasma and cerebrospinal fluid (at protein level). Highly expressed in the choroid plexus. Detected in liver.|||Homotetramer. Dimer of dimers. In the homotetramer, subunits assemble around a central channel that can accommodate two ligand molecules. Interacts with RBP4 (By similarity).|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/13616:NUP155 ^@ http://purl.uniprot.org/uniprot/F7FWK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/13616:SFT2D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/13616:PGM2L1 ^@ http://purl.uniprot.org/uniprot/F7B0Q5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/13616:CNR2 ^@ http://purl.uniprot.org/uniprot/F7CMJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GRK1 ^@ http://purl.uniprot.org/uniprot/F7FA38 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/13616:LOC100023593 ^@ http://purl.uniprot.org/uniprot/F7E0M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRAF3 ^@ http://purl.uniprot.org/uniprot/F7DTX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100013449 ^@ http://purl.uniprot.org/uniprot/F7FD88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CENPB ^@ http://purl.uniprot.org/uniprot/F6WYF8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAM49A ^@ http://purl.uniprot.org/uniprot/F6ZPT8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/13616:PPP1R1B ^@ http://purl.uniprot.org/uniprot/F6S0P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein phosphatase inhibitor 1 family.|||Cytoplasm|||Inhibitor of protein-phosphatase 1. http://togogenome.org/gene/13616:LOC100024874 ^@ http://purl.uniprot.org/uniprot/F6VE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/13616:VN2R630 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6H3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AVP ^@ http://purl.uniprot.org/uniprot/F7D0Q1 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/13616:TNIP2 ^@ http://purl.uniprot.org/uniprot/F7D8K2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:PLD3 ^@ http://purl.uniprot.org/uniprot/F7FNI6 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/13616:PIGS ^@ http://purl.uniprot.org/uniprot/F6QSI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:PURG ^@ http://purl.uniprot.org/uniprot/F7ANE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/13616:SLC25A20 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDJ7|||http://purl.uniprot.org/uniprot/F7DSV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:D2HGDH ^@ http://purl.uniprot.org/uniprot/F6PH88 ^@ Similarity ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family. http://togogenome.org/gene/13616:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/F6ZYG5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/13616:MED22 ^@ http://purl.uniprot.org/uniprot/F6T0Z7 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/13616:CASQ1 ^@ http://purl.uniprot.org/uniprot/F6QTC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/13616:PSMB10 ^@ http://purl.uniprot.org/uniprot/F7FVC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:SLC7A10 ^@ http://purl.uniprot.org/uniprot/F7CE83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:INO80C ^@ http://purl.uniprot.org/uniprot/F6Y650 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZC1 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/13616:TGFBI ^@ http://purl.uniprot.org/uniprot/F7D796 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/13616:RTCB ^@ http://purl.uniprot.org/uniprot/F7BCY1 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/13616:E2F3 ^@ http://purl.uniprot.org/uniprot/F6WI20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/13616:BRMS1L ^@ http://purl.uniprot.org/uniprot/F6T0C6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DUSP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100014880 ^@ http://purl.uniprot.org/uniprot/F6Z1Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LMOD1 ^@ http://purl.uniprot.org/uniprot/F6Y639 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/13616:CORO2B ^@ http://purl.uniprot.org/uniprot/F7CQ44 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/13616:NPM3 ^@ http://purl.uniprot.org/uniprot/F7GE61 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/13616:DRD5 ^@ http://purl.uniprot.org/uniprot/F7APR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FGF11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP66 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE78|||http://purl.uniprot.org/uniprot/A0A5F8GG28|||http://purl.uniprot.org/uniprot/A0A5F8H2D1 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/13616:ELOVL7 ^@ http://purl.uniprot.org/uniprot/F6QM63 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/13616:LOC100017630 ^@ http://purl.uniprot.org/uniprot/F7F7L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100030208 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TNPO2 ^@ http://purl.uniprot.org/uniprot/F6PVQ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:IRF2BP2 ^@ http://purl.uniprot.org/uniprot/F7GEJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/13616:GIMAP6 ^@ http://purl.uniprot.org/uniprot/A0A5F8H098 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:VN2R557 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBK7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ZFYVE28 ^@ http://purl.uniprot.org/uniprot/F7AES7 ^@ Similarity ^@ Belongs to the lst-2 family. http://togogenome.org/gene/13616:THEMIS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEI8 ^@ Similarity ^@ Belongs to the themis family. http://togogenome.org/gene/13616:SULF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI11|||http://purl.uniprot.org/uniprot/F7DW81 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Exhibits arylsulfatase activity and highly specific endoglucosamine-6-sulfatase activity. It can remove sulfate from the C-6 position of glucosamine within specific subregions of intact heparin.|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:AGPS ^@ http://purl.uniprot.org/uniprot/F6YBI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FAD-binding oxidoreductase/transferase type 4 family.|||Catalyzes the exchange of an acyl for a long-chain alkyl group and the formation of the ether bond in the biosynthesis of ether phospholipids.|||Homodimer.|||Peroxisome http://togogenome.org/gene/13616:CCT6A ^@ http://purl.uniprot.org/uniprot/F7BUJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/13616:WDFY1 ^@ http://purl.uniprot.org/uniprot/F6XE34 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:LOC103100950 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6Q2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Possibly involved in the ontogenesis of pituitary gonadotropes, as well as somatotropes, lactotropes and caudomedial thyrotropes. http://togogenome.org/gene/13616:CD320 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ67 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ADAM33 ^@ http://purl.uniprot.org/uniprot/F6UN04 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ARTN ^@ http://purl.uniprot.org/uniprot/F6Q199 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/13616:TCHP ^@ http://purl.uniprot.org/uniprot/F6SVU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCHP family.|||cytoskeleton http://togogenome.org/gene/13616:MAP3K8 ^@ http://purl.uniprot.org/uniprot/F7EA12 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/13616:LOC100619788 ^@ http://purl.uniprot.org/uniprot/F7GG30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SYVN1 ^@ http://purl.uniprot.org/uniprot/F7BYZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRD1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CPSF2 ^@ http://purl.uniprot.org/uniprot/F6QCB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/13616:PDE6B ^@ http://purl.uniprot.org/uniprot/F6W037 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:JUNB ^@ http://purl.uniprot.org/uniprot/A0A5F8GZN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/13616:CHMP2B ^@ http://purl.uniprot.org/uniprot/F6VMU4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:FOXO6 ^@ http://purl.uniprot.org/uniprot/F6WVS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100022215 ^@ http://purl.uniprot.org/uniprot/F6ZVZ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/13616:UCP3 ^@ http://purl.uniprot.org/uniprot/F7DAU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:C3H18orf32 ^@ http://purl.uniprot.org/uniprot/F7C7W0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UPF0729 family.|||Interacts with DERL1 and AMFR.|||May activate the NF-kappa-B signaling pathway. http://togogenome.org/gene/13616:NDUFB11 ^@ http://purl.uniprot.org/uniprot/F7BRP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB11 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SSR3 ^@ http://purl.uniprot.org/uniprot/F7AHP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-gamma family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/13616:SEZ6L2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRA9|||http://purl.uniprot.org/uniprot/A0A5F8GSC4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:UNC45A ^@ http://purl.uniprot.org/uniprot/A0A5F8H8V9 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/13616:LYRM7 ^@ http://purl.uniprot.org/uniprot/F6RYU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein UQCRFS1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane.|||Belongs to the complex I LYR family.|||Interacts with UQCRFS1.|||Mitochondrion matrix http://togogenome.org/gene/13616:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/13616:POLA2 ^@ http://purl.uniprot.org/uniprot/F6WAX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/13616:IK ^@ http://purl.uniprot.org/uniprot/F6RJP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/13616:THPO ^@ http://purl.uniprot.org/uniprot/F7G570 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/13616:PDGFRB ^@ http://purl.uniprot.org/uniprot/F6XAD2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:POLR3G ^@ http://purl.uniprot.org/uniprot/F7FXJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/13616:KCNE2 ^@ http://purl.uniprot.org/uniprot/F7E665 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/13616:LOC100012527 ^@ http://purl.uniprot.org/uniprot/F6UY50 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/13616:LOC100012302 ^@ http://purl.uniprot.org/uniprot/F6VZJ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:SNX9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/13616:GJA1 ^@ http://purl.uniprot.org/uniprot/F7E4P6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:ERH ^@ http://purl.uniprot.org/uniprot/F6VPB7 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/13616:ZDHHC5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGA3|||http://purl.uniprot.org/uniprot/F7EAG3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:PDE2A ^@ http://purl.uniprot.org/uniprot/F7EBA5 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:LOC100027301 ^@ http://purl.uniprot.org/uniprot/F7GI23 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/13616:ZEB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G233|||http://purl.uniprot.org/uniprot/F6Y0B4 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/13616:RBP2 ^@ http://purl.uniprot.org/uniprot/F7BQ22 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:LGR5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0S9|||http://purl.uniprot.org/uniprot/F7BZE9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RLN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/13616:LOC100619842 ^@ http://purl.uniprot.org/uniprot/F6ZZ92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PPM1K ^@ http://purl.uniprot.org/uniprot/F6QTI3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/13616:SCRN1 ^@ http://purl.uniprot.org/uniprot/F6XZ29 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/13616:LOC103101367 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/13616:B3GALT1 ^@ http://purl.uniprot.org/uniprot/F7FAR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:UBE2K ^@ http://purl.uniprot.org/uniprot/F7AQ16 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:CDK7 ^@ http://purl.uniprot.org/uniprot/F6TC82 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/13616:RPL24 ^@ http://purl.uniprot.org/uniprot/F6W129 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/13616:CRX ^@ http://purl.uniprot.org/uniprot/A0A5F8GF02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:VWF ^@ http://purl.uniprot.org/uniprot/F5XVB7 ^@ Subcellular Location Annotation|||Subunit ^@ Multimeric. Interacts with F8.|||extracellular matrix http://togogenome.org/gene/13616:NKX6-3 ^@ http://purl.uniprot.org/uniprot/F6YT06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NPY2R ^@ http://purl.uniprot.org/uniprot/F6UCA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ITPK1 ^@ http://purl.uniprot.org/uniprot/F7G3M0 ^@ Similarity ^@ Belongs to the ITPK1 family. http://togogenome.org/gene/13616:AFAP1L1 ^@ http://purl.uniprot.org/uniprot/F6XZ22 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in podosome and invadosome formation.|||invadopodium|||podosome http://togogenome.org/gene/13616:NAPRT ^@ http://purl.uniprot.org/uniprot/F7CI40 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/13616:AXL ^@ http://purl.uniprot.org/uniprot/F6VDX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ENTPD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H455|||http://purl.uniprot.org/uniprot/F7FL76 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:KIF12 ^@ http://purl.uniprot.org/uniprot/F7FMT1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:LOC100029152 ^@ http://purl.uniprot.org/uniprot/F7B7Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100011074 ^@ http://purl.uniprot.org/uniprot/F7EGS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A5F8HFJ1|||http://purl.uniprot.org/uniprot/A0A5F8HHE0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:PLAGL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:LOC100017167 ^@ http://purl.uniprot.org/uniprot/F6TBU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ANAPC11 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6S1 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/13616:TRIM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100018166 ^@ http://purl.uniprot.org/uniprot/F6Q969 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CD9 ^@ http://purl.uniprot.org/uniprot/F7GEM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Cell membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/13616:SUPT16H ^@ http://purl.uniprot.org/uniprot/F7BV95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/13616:CMKLR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:REEP5 ^@ http://purl.uniprot.org/uniprot/F7D9H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/13616:SLC26A5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG90|||http://purl.uniprot.org/uniprot/A0A5F8H0P0|||http://purl.uniprot.org/uniprot/F6TKX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Motor protein that converts auditory stimuli to length changes in outer hair cells and mediates sound amplification in the mammalian hearing organ. http://togogenome.org/gene/13616:NT5DC1 ^@ http://purl.uniprot.org/uniprot/F6Z7W4 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/13616:ALCAM ^@ http://purl.uniprot.org/uniprot/A0A5F8G2T3|||http://purl.uniprot.org/uniprot/F7CKB1 ^@ Subcellular Location Annotation ^@ Cell membrane|||axon|||dendrite http://togogenome.org/gene/13616:TOP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G979|||http://purl.uniprot.org/uniprot/F6X447 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/13616:HAT1 ^@ http://purl.uniprot.org/uniprot/F7CAY9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/13616:SNX5 ^@ http://purl.uniprot.org/uniprot/F7BXX6 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/13616:GALNT16 ^@ http://purl.uniprot.org/uniprot/F6VPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:NDUFB10 ^@ http://purl.uniprot.org/uniprot/F7FYS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit that is involved in the functional assembly of the mitochondrial respiratory chain complex I. Complex I has an NADH dehydrogenase activity with ubiquinone as an immediate electron acceptor and mediates the transfer of electrons from NADH to the respiratory chain.|||Belongs to the complex I NDUFB10 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:DZIP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6N7|||http://purl.uniprot.org/uniprot/F6U2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RING-box family.|||Cytoplasm http://togogenome.org/gene/13616:GPC4 ^@ http://purl.uniprot.org/uniprot/F6QDK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/13616:PRDM15 ^@ http://purl.uniprot.org/uniprot/F6SNW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100021046 ^@ http://purl.uniprot.org/uniprot/F7ANM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A5F8HEV6|||http://purl.uniprot.org/uniprot/F7FPX9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:SAP30 ^@ http://purl.uniprot.org/uniprot/F7GBR9 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/13616:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4X4|||http://purl.uniprot.org/uniprot/F6PH95 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/13616:C4H21orf59 ^@ http://purl.uniprot.org/uniprot/F6V188 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP298 family.|||cilium basal body http://togogenome.org/gene/13616:CNIH3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/13616:LMOD2 ^@ http://purl.uniprot.org/uniprot/F7AK27 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/13616:B3GLCT ^@ http://purl.uniprot.org/uniprot/F7G0B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100025197 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TM9SF2 ^@ http://purl.uniprot.org/uniprot/F7A9R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/13616:CCT3 ^@ http://purl.uniprot.org/uniprot/F6XJH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/13616:BICD2 ^@ http://purl.uniprot.org/uniprot/F6PIY7 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/13616:INTS2 ^@ http://purl.uniprot.org/uniprot/F6X1I7 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/13616:ERRFI1 ^@ http://purl.uniprot.org/uniprot/F7A9H2 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/13616:CLN5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFZ6 ^@ Similarity ^@ Belongs to the CLN5 family. http://togogenome.org/gene/13616:MRTO4 ^@ http://purl.uniprot.org/uniprot/F7BR65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/13616:GJA5 ^@ http://purl.uniprot.org/uniprot/F7EFL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:OGDH ^@ http://purl.uniprot.org/uniprot/F7DSQ0 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/13616:PKN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G616 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/13616:TNFSF8 ^@ http://purl.uniprot.org/uniprot/F6QMZ0 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/13616:HABP4 ^@ http://purl.uniprot.org/uniprot/F7E764 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:HOXD10 ^@ http://purl.uniprot.org/uniprot/F7AWE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:TFIP11 ^@ http://purl.uniprot.org/uniprot/A4UMC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Cytoplasm|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2 (By similarity).|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix (By similarity).|||Nucleus http://togogenome.org/gene/13616:MYOG ^@ http://purl.uniprot.org/uniprot/F6ZFK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MFSD4A ^@ http://purl.uniprot.org/uniprot/F6T5Y2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:B3GAT1 ^@ http://purl.uniprot.org/uniprot/F7DJX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:ABL2 ^@ http://purl.uniprot.org/uniprot/F7FED8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:TPM4 ^@ http://purl.uniprot.org/uniprot/F7GGJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/13616:PPP3CC ^@ http://purl.uniprot.org/uniprot/F7BLB6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/13616:LOC100011522 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:RAB39A ^@ http://purl.uniprot.org/uniprot/F7E803 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100025413 ^@ http://purl.uniprot.org/uniprot/F7FKD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NDUFA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5G8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:RPRM ^@ http://purl.uniprot.org/uniprot/A0A5F8H5N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reprimo family.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:PLA2G4E ^@ http://purl.uniprot.org/uniprot/A0A5F8GD10|||http://purl.uniprot.org/uniprot/F7E3Q7 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/13616:LOC100019224 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/13616:SF3A1 ^@ http://purl.uniprot.org/uniprot/F7DA32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RNPS1 ^@ http://purl.uniprot.org/uniprot/F7B375 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the splicing factor SR family.|||Found in mRNA splicing-dependent exon junction complexes (EJC). Found in a post-splicing complex with NXF1, RBM8A, UPF1, UPF2, UPF3A, UPF3B and RNPS1. Component of the heterotrimeric ASAP (apoptosis- and splicing-associated protein) and PSAP complexes consisting of RNPS1, SAP18 and either ACIN1 or PNN, respectively; the ASAP and PSAP complexes probably are formed mutually exclusive. Component of the active spliceosome. Associates with polysomes. Interacts with the cleaved p110 isoform of CDC2L1, CSNK2A1, PNN, SART3, SRP54, SRRM1 and TRA2B/SFRS10.|||Nucleus speckle http://togogenome.org/gene/13616:MGAT2 ^@ http://purl.uniprot.org/uniprot/F6SNS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 16 (GT16) protein family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:DNAJC27 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6K7 ^@ Function|||Subunit ^@ GTPase which can activate the MEK/ERK pathway and induce cell transformation when overexpressed. May act as a nuclear scaffold for MAPK1, probably by association with MAPK1 nuclear export signal leading to enhanced ERK1/ERK2 signaling.|||Interacts directly with MAPK1 (wild-type and kinase-deficient forms). Interacts directly (in GTP-bound form) with MAP2K1 (wild-type and kinase-deficient forms). http://togogenome.org/gene/13616:CDK20 ^@ http://purl.uniprot.org/uniprot/F6XM60 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100028081 ^@ http://purl.uniprot.org/uniprot/F7C9Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TECPR1 ^@ http://purl.uniprot.org/uniprot/F7F2L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TECPR1 family.|||Lysosome membrane|||autophagosome membrane http://togogenome.org/gene/13616:GCH1 ^@ http://purl.uniprot.org/uniprot/F7GE69 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/13616:FCF1 ^@ http://purl.uniprot.org/uniprot/F7B4X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/13616:ALOX5AP ^@ http://purl.uniprot.org/uniprot/F7DAM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100014039 ^@ http://purl.uniprot.org/uniprot/F6UNW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/13616:LOC100618776 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPS1 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:UTP23 ^@ http://purl.uniprot.org/uniprot/F6UDS3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:ZFPM2 ^@ http://purl.uniprot.org/uniprot/F6YLF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BMP2 ^@ http://purl.uniprot.org/uniprot/F7GIY5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:CMTM7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PROX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR59|||http://purl.uniprot.org/uniprot/F6TZI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A5F8GI40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:MRPS24 ^@ http://purl.uniprot.org/uniprot/A0A5F8G646 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Mitochondrion http://togogenome.org/gene/13616:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/F6W7N1 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/13616:PPP1CB ^@ http://purl.uniprot.org/uniprot/F7AJD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:NCL ^@ http://purl.uniprot.org/uniprot/F7BWB5 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:MSL3 ^@ http://purl.uniprot.org/uniprot/F6WEX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:monDomV1R1226 ^@ http://purl.uniprot.org/uniprot/F7F0Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CD247 ^@ http://purl.uniprot.org/uniprot/F7G531 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TUBB2B ^@ http://purl.uniprot.org/uniprot/A0A5F8HCT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:SAXO2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKE8|||http://purl.uniprot.org/uniprot/F6WCT9 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/13616:LOC100030411 ^@ http://purl.uniprot.org/uniprot/F7A7Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TM7SF2 ^@ http://purl.uniprot.org/uniprot/F6X4J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/13616:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A5F8G800|||http://purl.uniprot.org/uniprot/F6V2A6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/13616:LOC100010036 ^@ http://purl.uniprot.org/uniprot/F6Q228 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100024672 ^@ http://purl.uniprot.org/uniprot/F6TXV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||cytoskeleton http://togogenome.org/gene/13616:SLC4A4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEA5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:PRR5L ^@ http://purl.uniprot.org/uniprot/F6YHY4 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/13616:ACTL7B ^@ http://purl.uniprot.org/uniprot/F6XB87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/13616:FASN ^@ http://purl.uniprot.org/uniprot/F7GKK4 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/13616:DGKQ ^@ http://purl.uniprot.org/uniprot/F6VRH1 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/13616:SIX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Nucleus http://togogenome.org/gene/13616:TFAP2A ^@ http://purl.uniprot.org/uniprot/A0A5F8G665|||http://purl.uniprot.org/uniprot/A0A5F8H0X1|||http://purl.uniprot.org/uniprot/F6SSJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AP-2 family.|||Nucleus http://togogenome.org/gene/13616:GJB1 ^@ http://purl.uniprot.org/uniprot/F6SVW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Beta-type (group I) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:CAPZA2 ^@ http://purl.uniprot.org/uniprot/Q2QL99 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. Component of the WASH complex, composed of F-actin-capping protein subunit alpha (CAPZA1, CAPZA2 or CAPZA3), F-actin-capping protein subunit beta (CAPZB), WASHC1, WASHC2, WASHC3, WASHC4 and WASHC5. Interacts with RCSD1/CAPZIP (By similarity). Directly interacts with CRACD; this interaction decreases binding to actin (By similarity). http://togogenome.org/gene/13616:TFDP1 ^@ http://purl.uniprot.org/uniprot/F7ED92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/13616:ALPI ^@ http://purl.uniprot.org/uniprot/F7G4Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100025711 ^@ http://purl.uniprot.org/uniprot/F6Q6I7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:PYCRL ^@ http://purl.uniprot.org/uniprot/F6SQV0 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/13616:LOC100030333 ^@ http://purl.uniprot.org/uniprot/F7CX27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100023663 ^@ http://purl.uniprot.org/uniprot/F6WGJ1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC103097066 ^@ http://purl.uniprot.org/uniprot/F7FEP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/13616:KIF15 ^@ http://purl.uniprot.org/uniprot/F6S782 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||spindle http://togogenome.org/gene/13616:ADCY9 ^@ http://purl.uniprot.org/uniprot/F7EQQ4 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family. http://togogenome.org/gene/13616:LIMK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5F0|||http://purl.uniprot.org/uniprot/F6QSD0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/13616:BLM ^@ http://purl.uniprot.org/uniprot/F6RXI0 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/13616:ING3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7X2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/13616:BAZ1A ^@ http://purl.uniprot.org/uniprot/A0A5F8GW38|||http://purl.uniprot.org/uniprot/F7G1J7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100018133 ^@ http://purl.uniprot.org/uniprot/F6V7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103100557 ^@ http://purl.uniprot.org/uniprot/F6U0U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:KCNK12 ^@ http://purl.uniprot.org/uniprot/F7DPG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:FZD10 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R552 ^@ http://purl.uniprot.org/uniprot/F6WQ56 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CCDC103 ^@ http://purl.uniprot.org/uniprot/F6WJE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/13616:TMEM170A ^@ http://purl.uniprot.org/uniprot/A0A5F8G3M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/13616:LOC100028564 ^@ http://purl.uniprot.org/uniprot/F7AJW2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||Membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/13616:CLCN6 ^@ http://purl.uniprot.org/uniprot/F7BC48 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:RAB11FIP4 ^@ http://purl.uniprot.org/uniprot/F6ZI91 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/13616:TMEM39A ^@ http://purl.uniprot.org/uniprot/F7B771 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/13616:NRM ^@ http://purl.uniprot.org/uniprot/F7BR41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nurim family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/13616:LOC100024653 ^@ http://purl.uniprot.org/uniprot/A0A5F8H890|||http://purl.uniprot.org/uniprot/F6PZH1 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:TMEM242 ^@ http://purl.uniprot.org/uniprot/F6SWN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM242 family.|||Membrane http://togogenome.org/gene/13616:TAF13 ^@ http://purl.uniprot.org/uniprot/A0A5F8H889|||http://purl.uniprot.org/uniprot/F7G3P1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SNRPC ^@ http://purl.uniprot.org/uniprot/F6VBS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. snrpc/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates E complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/13616:ZC3H12C ^@ http://purl.uniprot.org/uniprot/A0A5F8GYA3|||http://purl.uniprot.org/uniprot/F7E8N8 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/13616:LOC100011527 ^@ http://purl.uniprot.org/uniprot/F7GEA2 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:SDHD ^@ http://purl.uniprot.org/uniprot/F6T7B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/13616:UBL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM48 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ELOVL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU42|||http://purl.uniprot.org/uniprot/A0A5F8GU88 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL2 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C20:4(n-6) acyl-CoA. Condensing enzyme that catalyzes the synthesis of polyunsaturated very long chain fatty acid (C20- and C22-PUFA). May participate to the production of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/13616:ORM1 ^@ http://purl.uniprot.org/uniprot/F7DTZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/13616:LETM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:PARP10 ^@ http://purl.uniprot.org/uniprot/F7A7Q9 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:VWA1 ^@ http://purl.uniprot.org/uniprot/F7B879 ^@ Subcellular Location Annotation ^@ Membrane|||basement membrane http://togogenome.org/gene/13616:SPG7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN77 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/13616:NMT2 ^@ http://purl.uniprot.org/uniprot/F6XMS8 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/13616:DMRT2 ^@ http://purl.uniprot.org/uniprot/F7GCC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/13616:SNRK ^@ http://purl.uniprot.org/uniprot/F6UJD0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LPL ^@ http://purl.uniprot.org/uniprot/F6VCX0 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/13616:LOC100019150 ^@ http://purl.uniprot.org/uniprot/F7E8I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:POPC1 ^@ http://purl.uniprot.org/uniprot/Q28464 ^@ Similarity ^@ Belongs to the DNA photolyase class-2 family. http://togogenome.org/gene/13616:LOC100024047 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9Q1 ^@ Function|||Similarity ^@ Belongs to the CMP-Neu5Ac hydroxylase family.|||Sialic acids are components of carbohydrate chains of glycoconjugates and are involved in cell-cell recognition and cell-pathogen interactions. Catalyzes the conversion of CMP-N-acetylneuraminic acid (CMP-Neu5Ac) into its hydroxylated derivative CMP-N-glycolylneuraminic acid (CMP-Neu5Gc), a sialic acid abundantly expressed at the surface of many cells. http://togogenome.org/gene/13616:LUM ^@ http://purl.uniprot.org/uniprot/F6SHS6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/13616:SGO2 ^@ http://purl.uniprot.org/uniprot/F6PKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/13616:MRPS18B ^@ http://purl.uniprot.org/uniprot/F6ZQK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bS18 family. Mitochondrion-specific ribosomal protein mS40 subfamily.|||Mitochondrion http://togogenome.org/gene/13616:RALY ^@ http://purl.uniprot.org/uniprot/F7EJ60 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/13616:TYMP ^@ http://purl.uniprot.org/uniprot/A0A5F8HE47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Catalyzes the reversible phosphorolysis of thymidine. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.|||Homodimer. http://togogenome.org/gene/13616:LOC100018872 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPL8 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/13616:DDX4 ^@ http://purl.uniprot.org/uniprot/F6VDB2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:TDGF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQJ1 ^@ Caution|||Similarity ^@ Belongs to the EGF-CFC (Cripto-1/FRL1/Cryptic) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TBXA2R ^@ http://purl.uniprot.org/uniprot/F6W8V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SIX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MEGF10 ^@ http://purl.uniprot.org/uniprot/F7B542 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PAPPA2 ^@ http://purl.uniprot.org/uniprot/F7CFD6 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MAB21L1 ^@ http://purl.uniprot.org/uniprot/F6TNJ5 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/13616:LOC100017286 ^@ http://purl.uniprot.org/uniprot/F6PZ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DNASE1L2 ^@ http://purl.uniprot.org/uniprot/A0EQL1 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/13616:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Z7|||http://purl.uniprot.org/uniprot/F7BNP3|||http://purl.uniprot.org/uniprot/F7GG79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/13616:SLIT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGU6|||http://purl.uniprot.org/uniprot/A0A5F8GUJ9|||http://purl.uniprot.org/uniprot/A0A5F8GZY7|||http://purl.uniprot.org/uniprot/F6W5I6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:GRAP2 ^@ http://purl.uniprot.org/uniprot/F7BQB2|||http://purl.uniprot.org/uniprot/F7BQD1 ^@ Similarity ^@ Belongs to the GRB2/sem-5/DRK family. http://togogenome.org/gene/13616:GPT ^@ http://purl.uniprot.org/uniprot/F7AQB9 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/13616:BRI3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRI3 family.|||Membrane|||perinuclear region http://togogenome.org/gene/13616:COPB2 ^@ http://purl.uniprot.org/uniprot/F7BQ26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/13616:KYNU ^@ http://purl.uniprot.org/uniprot/F6Q3X0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively. Has a preference for the L-3-hydroxy form. Also has cysteine-conjugate-beta-lyase activity.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:B3GALT2 ^@ http://purl.uniprot.org/uniprot/F6RD08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:CACUL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GET1 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/13616:NDP ^@ http://purl.uniprot.org/uniprot/A0A5F8G428 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:TXNL4A ^@ http://purl.uniprot.org/uniprot/A0A5F8H5Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/13616:KAT5 ^@ http://purl.uniprot.org/uniprot/F7AWF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/13616:STX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFK4|||http://purl.uniprot.org/uniprot/A0A5F8GGV0|||http://purl.uniprot.org/uniprot/F6ZTR8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/13616:LOC100014035 ^@ http://purl.uniprot.org/uniprot/F6Z024 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/13616:LOC100021807 ^@ http://purl.uniprot.org/uniprot/F6X027 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100019123 ^@ http://purl.uniprot.org/uniprot/F7BUJ2 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth. Could also have a single-stranded nucleic acid-binding activity and could play a role in RNA and/or DNA metabolism. It may also have a role in the development of malignancy and the growth progression of some tumors.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH.|||Nucleus http://togogenome.org/gene/13616:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A5F8HF40|||http://purl.uniprot.org/uniprot/F6RUF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:BCAS2 ^@ http://purl.uniprot.org/uniprot/F6R986 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPF27 family.|||Nucleus http://togogenome.org/gene/13616:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/F7G5M0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:TLX1 ^@ http://purl.uniprot.org/uniprot/F7EGZ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RACK1 ^@ http://purl.uniprot.org/uniprot/F6VVG7 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/13616:LPAR1 ^@ http://purl.uniprot.org/uniprot/F7DRX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/13616:ACSF3 ^@ http://purl.uniprot.org/uniprot/F7DU27 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:FZD6 ^@ http://purl.uniprot.org/uniprot/F7CZ56 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MICAL2 ^@ http://purl.uniprot.org/uniprot/F7CXM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100030002 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7Q2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:IRAK2 ^@ http://purl.uniprot.org/uniprot/F7AID5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Binds to the IL-1 type I receptor following IL-1 engagement, triggering intracellular signaling cascades leading to transcriptional up-regulation and mRNA stabilization.|||Interacts with MYD88. IL-1 stimulation leads to the formation of a signaling complex which dissociates from the IL-1 receptor following the binding of PELI1. http://togogenome.org/gene/13616:SSH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H656|||http://purl.uniprot.org/uniprot/A0A5F8HD36|||http://purl.uniprot.org/uniprot/F6SH18 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/13616:PPP2R4 ^@ http://purl.uniprot.org/uniprot/F7CXG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:B3GALT4 ^@ http://purl.uniprot.org/uniprot/F6X7H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:GABPA ^@ http://purl.uniprot.org/uniprot/F6QZT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:SLC6A17 ^@ http://purl.uniprot.org/uniprot/F6WZU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:METTL4 ^@ http://purl.uniprot.org/uniprot/F7GDI0 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/13616:LOC100026094 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Catalyzes the deimination of arginine residues of proteins.|||Cytoplasm http://togogenome.org/gene/13616:LOC100020543 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEI6|||http://purl.uniprot.org/uniprot/F7E8W9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:AMIGO1 ^@ http://purl.uniprot.org/uniprot/F6TWW3 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/13616:DPY30 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVZ3 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/13616:PLA2G12A ^@ http://purl.uniprot.org/uniprot/F6WX38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/13616:CWC25 ^@ http://purl.uniprot.org/uniprot/F6WUE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CWC25 family.|||Nucleus http://togogenome.org/gene/13616:P4HB ^@ http://purl.uniprot.org/uniprot/F6Q3U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:DACT1 ^@ http://purl.uniprot.org/uniprot/F7ELJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dapper family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100012815 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC27A5 ^@ http://purl.uniprot.org/uniprot/K7E5H1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:INPP1 ^@ http://purl.uniprot.org/uniprot/F6XX24 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/13616:GNRH1 ^@ http://purl.uniprot.org/uniprot/F7CI22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GnRH family.|||Secreted|||Stimulates the secretion of gonadotropins; it stimulates the secretion of both luteinizing and follicle-stimulating hormones. http://togogenome.org/gene/13616:FBXL5 ^@ http://purl.uniprot.org/uniprot/F6YQZ8 ^@ Subcellular Location Annotation ^@ perinuclear region http://togogenome.org/gene/13616:PCID2 ^@ http://purl.uniprot.org/uniprot/F7G9F9 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/13616:CD163 ^@ http://purl.uniprot.org/uniprot/F7ENX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VEZT ^@ http://purl.uniprot.org/uniprot/A0A5F8HBR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vezatin family.|||Cell membrane|||Membrane|||Nucleus|||adherens junction http://togogenome.org/gene/13616:TSPAN11 ^@ http://purl.uniprot.org/uniprot/F6PSQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:SUSD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ITGB6 ^@ http://purl.uniprot.org/uniprot/F6ZCH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/13616:SPAST ^@ http://purl.uniprot.org/uniprot/A0A5F8HE08|||http://purl.uniprot.org/uniprot/F6WWB5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent microtubule severing protein that specifically recognizes and cuts microtubules that are polyglutamylated. Preferentially recognizes and acts on microtubules decorated with short polyglutamate tails: severing activity increases as the number of glutamates per tubulin rises from one to eight, but decreases beyond this glutamylation threshold. Severing activity is not dependent on tubulin acetylation or detyrosination. Microtubule severing promotes reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. It is critical for the biogenesis and maintenance of complex microtubule arrays in axons, spindles and cilia. SPAST is involved in abscission step of cytokinesis and nuclear envelope reassembly during anaphase in cooperation with the ESCRT-III complex. Recruited at the midbody, probably by IST1, and participates in membrane fission during abscission together with the ESCRT-III complex. Recruited to the nuclear membrane by IST1 and mediates microtubule severing, promoting nuclear envelope sealing and mitotic spindle disassembly during late anaphase. Required for membrane traffic from the endoplasmic reticulum (ER) to the Golgi and endosome recycling. Recruited by IST1 to endosomes and regulates early endosomal tubulation and recycling by mediating microtubule severing. Probably plays a role in axon growth and the formation of axonal branches.|||Allosteric enzyme with a cooperative mechanism; at least two neighbor subunits influence each other strongly in spastin hexamers. Microtubule binding promotes cooperative interactions among spastin subunits.|||Belongs to the AAA ATPase family. Spastin subfamily.|||Cytoplasm|||Endoplasmic reticulum|||Homohexamer. Mostly monomeric, but assembles into hexameric structure for short periods of time. Oligomerization seems to be a prerequisite for catalytic activity. Binding to ATP in a cleft between two adjacent subunits stabilizes the homohexameric form. Binds to microtubules at least in part via the alpha-tubulin and beta-tubulin tails. The hexamer adopts a ring conformation through which microtubules pass prior to being severed. Does not interact strongly with tubulin heterodimers. Interacts (via MIT domain) with CHMP1B; the interaction is direct. Interacts with SSNA1. Interacts with ATL1. Interacts with RTN1. Interacts with ZFYVE27. Interacts with REEP1. Interacts (via MIT domain) with IST1.|||Membrane|||Midbody|||Nucleus|||axon|||centrosome|||cytoskeleton|||perinuclear region|||spindle http://togogenome.org/gene/13616:BIVM ^@ http://purl.uniprot.org/uniprot/F6SAK9 ^@ Similarity ^@ Belongs to the BIVM family. http://togogenome.org/gene/13616:SPAG7 ^@ http://purl.uniprot.org/uniprot/F6YNM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC41A1 ^@ http://purl.uniprot.org/uniprot/F6SNK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/13616:LOC100014708 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF32|||http://purl.uniprot.org/uniprot/F7EFJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/13616:SEC22A ^@ http://purl.uniprot.org/uniprot/F6PSR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/13616:NELFE ^@ http://purl.uniprot.org/uniprot/F7FHL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NELF-E family.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:H3F3B ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ95 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:DPT ^@ http://purl.uniprot.org/uniprot/A0A5F8G6P1 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/13616:ATPAF1 ^@ http://purl.uniprot.org/uniprot/F6W119 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/13616:PRKD3 ^@ http://purl.uniprot.org/uniprot/F7FGD2 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:CACNB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB94|||http://purl.uniprot.org/uniprot/A0A5F8HIV3|||http://purl.uniprot.org/uniprot/B6IDG2|||http://purl.uniprot.org/uniprot/F6Q927 ^@ Similarity ^@ Belongs to the calcium channel beta subunit family. http://togogenome.org/gene/13616:RBBP4 ^@ http://purl.uniprot.org/uniprot/F7AJD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CTSK ^@ http://purl.uniprot.org/uniprot/A0A5F8H101 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase C1 family.|||Cell membrane|||Lysosome|||Secreted http://togogenome.org/gene/13616:HDHD3 ^@ http://purl.uniprot.org/uniprot/F6X2M1 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/13616:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2Z6|||http://purl.uniprot.org/uniprot/F7GE81 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/13616:LOC100027495 ^@ http://purl.uniprot.org/uniprot/F6PJD6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/13616:TDRD9 ^@ http://purl.uniprot.org/uniprot/F6VF39 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/13616:HGF ^@ http://purl.uniprot.org/uniprot/A0A5F8GFC6|||http://purl.uniprot.org/uniprot/F6Y0F0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Dimer of an alpha chain and a beta chain linked by a disulfide bond. Interacts with SRPX2; the interaction increases HGF mitogenic activity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Potent mitogen for mature parenchymal hepatocyte cells, seems to be a hepatotrophic factor, and acts as a growth factor for a broad spectrum of tissues and cell types. Activating ligand for the receptor tyrosine kinase MET by binding to it and promoting its dimerization. http://togogenome.org/gene/13616:LOC100010167 ^@ http://purl.uniprot.org/uniprot/F7DY38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ZHX1 ^@ http://purl.uniprot.org/uniprot/F6QW83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/13616:RBM47 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKK9|||http://purl.uniprot.org/uniprot/F7BKF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM47 family.|||Nucleus http://togogenome.org/gene/13616:CRYBB1 ^@ http://purl.uniprot.org/uniprot/F7G7F5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/13616:ABLIM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEZ9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:INO80 ^@ http://purl.uniprot.org/uniprot/F6TFW8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/13616:INSIG1 ^@ http://purl.uniprot.org/uniprot/F6US22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/13616:KIF20A ^@ http://purl.uniprot.org/uniprot/F7CE67 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:BBS7 ^@ http://purl.uniprot.org/uniprot/F7GJV3 ^@ Function|||Subunit ^@ Part of BBSome complex.|||The BBSome complex is thought to function as a coat complex required for sorting of specific membrane proteins to the primary cilia. The BBSome complex is required for ciliogenesis but is dispensable for centriolar satellite function. http://togogenome.org/gene/13616:TBX22 ^@ http://purl.uniprot.org/uniprot/F6TW49 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:BORCS5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5A0|||http://purl.uniprot.org/uniprot/F6PG67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:KITLG ^@ http://purl.uniprot.org/uniprot/A0A5F8G474|||http://purl.uniprot.org/uniprot/A0A5F8GDP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCF family.|||Cytoplasm|||Homodimer, non-covalently linked.|||Ligand for the receptor-type protein-tyrosine kinase KIT. Plays an essential role in the regulation of cell survival and proliferation, hematopoiesis, stem cell maintenance, gametogenesis, mast cell development, migration and function, and in melanogenesis.|||Secreted|||filopodium|||lamellipodium http://togogenome.org/gene/13616:PSD2 ^@ http://purl.uniprot.org/uniprot/F7CW81 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/13616:CCT5 ^@ http://purl.uniprot.org/uniprot/F7GDM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/13616:IMPAD1 ^@ http://purl.uniprot.org/uniprot/F7G2D4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/13616:ATP5H ^@ http://purl.uniprot.org/uniprot/A0A5F8GEJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100027666 ^@ http://purl.uniprot.org/uniprot/F7CMU3 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/13616:TUBB ^@ http://purl.uniprot.org/uniprot/F7F082 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/13616:SDE2 ^@ http://purl.uniprot.org/uniprot/F6VZ72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Nucleus http://togogenome.org/gene/13616:LOC100028437 ^@ http://purl.uniprot.org/uniprot/F7FJF7 ^@ Similarity ^@ Belongs to the CFAP43 family. http://togogenome.org/gene/13616:TPD52L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX98|||http://purl.uniprot.org/uniprot/A0A5F8H9E8 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/13616:SFT2D1 ^@ http://purl.uniprot.org/uniprot/F6TJQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/13616:VLDLR ^@ http://purl.uniprot.org/uniprot/A0A5F8GS69|||http://purl.uniprot.org/uniprot/F7BMW3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||clathrin-coated pit http://togogenome.org/gene/13616:LOC100013732 ^@ http://purl.uniprot.org/uniprot/F6X525 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/13616:MS4A5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G948 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:MRPL18 ^@ http://purl.uniprot.org/uniprot/F7EDX2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL18 family. http://togogenome.org/gene/13616:HSCB ^@ http://purl.uniprot.org/uniprot/F7BVB0 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/13616:SART3 ^@ http://purl.uniprot.org/uniprot/F6UVE9 ^@ Subcellular Location Annotation ^@ nucleoplasm http://togogenome.org/gene/13616:POMC ^@ http://purl.uniprot.org/uniprot/Q95J84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Anorexigenic peptide. Increases the pigmentation of skin by increasing melanin production in melanocytes.|||Belongs to the POMC family.|||Endogenous opiate.|||Endogenous orexigenic opiate.|||Secreted|||Stimulates the adrenal glands to release cortisol. http://togogenome.org/gene/13616:CNOT8 ^@ http://purl.uniprot.org/uniprot/F6PHB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/13616:TPK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTE9 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/13616:ERMAP ^@ http://purl.uniprot.org/uniprot/F6QE42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/13616:SPHKAP ^@ http://purl.uniprot.org/uniprot/A0A5F8GXF6|||http://purl.uniprot.org/uniprot/F6UG18 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/13616:PHKG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1W5 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/13616:LOC100032987 ^@ http://purl.uniprot.org/uniprot/F7G3B9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PLA2G15 ^@ http://purl.uniprot.org/uniprot/F7EQG0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/13616:NIPAL4 ^@ http://purl.uniprot.org/uniprot/F7BV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/13616:LHX3 ^@ http://purl.uniprot.org/uniprot/F7E0Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:HHEX ^@ http://purl.uniprot.org/uniprot/F7EGI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100024791 ^@ http://purl.uniprot.org/uniprot/F7F1D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100032028 ^@ http://purl.uniprot.org/uniprot/F6SPU8 ^@ Similarity ^@ Belongs to the PRORSD1 family. http://togogenome.org/gene/13616:EGFL6 ^@ http://purl.uniprot.org/uniprot/F6WWJ4 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:FAM131C ^@ http://purl.uniprot.org/uniprot/A0A5F8HLV3 ^@ Similarity ^@ Belongs to the FAM131 family. http://togogenome.org/gene/13616:PDCL ^@ http://purl.uniprot.org/uniprot/A0A5F8H8X0 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/13616:QSOX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCP6 ^@ Function|||Similarity ^@ Belongs to the quiescin-sulfhydryl oxidase (QSOX) family.|||Catalyzes the oxidation of sulfhydryl groups in peptide and protein thiols to disulfides with the reduction of oxygen to hydrogen peroxide. http://togogenome.org/gene/13616:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/F6SG91 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/13616:GDF10 ^@ http://purl.uniprot.org/uniprot/F6UZ74 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:ENGASE ^@ http://purl.uniprot.org/uniprot/F6QW59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/13616:FAM32A ^@ http://purl.uniprot.org/uniprot/F7G6F7 ^@ Similarity ^@ Belongs to the FAM32 family. http://togogenome.org/gene/13616:SLC18A1 ^@ http://purl.uniprot.org/uniprot/F6WAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1202 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EEF2 ^@ http://purl.uniprot.org/uniprot/F6T8K7 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/13616:FAN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHL9|||http://purl.uniprot.org/uniprot/F7CBU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/13616:SLC6A1 ^@ http://purl.uniprot.org/uniprot/F6SLD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:LOC100016303 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH76 ^@ Similarity|||Subunit ^@ Belongs to the SFTPD family.|||Oligomeric complex of 4 set of homotrimers. http://togogenome.org/gene/13616:LOC100022062 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5S9 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/13616:SIN3B ^@ http://purl.uniprot.org/uniprot/A0A5F8G735|||http://purl.uniprot.org/uniprot/F7CG40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:KIF24 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX18|||http://purl.uniprot.org/uniprot/K7E100 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:RAB3C ^@ http://purl.uniprot.org/uniprot/A0A5F8GNN1|||http://purl.uniprot.org/uniprot/F6R8N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/13616:SLC39A7 ^@ http://purl.uniprot.org/uniprot/F6T918 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:UBE2R2 ^@ http://purl.uniprot.org/uniprot/F7FAJ7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:RARS2 ^@ http://purl.uniprot.org/uniprot/F6PVI2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:SPO11 ^@ http://purl.uniprot.org/uniprot/F6X8N3 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/13616:SLC39A8 ^@ http://purl.uniprot.org/uniprot/F7DLB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NDNF ^@ http://purl.uniprot.org/uniprot/A0A5F8GTJ5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:C3H19orf25 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMH4 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/13616:NIP7 ^@ http://purl.uniprot.org/uniprot/F6YGD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 34S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/13616:LOC100028416 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ORMDL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/13616:LOC100011399 ^@ http://purl.uniprot.org/uniprot/F7DNQ9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:MAEA ^@ http://purl.uniprot.org/uniprot/F6WPZ4 ^@ Subcellular Location Annotation ^@ Nucleus matrix http://togogenome.org/gene/13616:LOC100618848 ^@ http://purl.uniprot.org/uniprot/F7AKW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VAMP4 ^@ http://purl.uniprot.org/uniprot/F6ZJ33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/13616:CD3G ^@ http://purl.uniprot.org/uniprot/F7F8D9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HOXB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/13616:ESF1 ^@ http://purl.uniprot.org/uniprot/F7ASI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/13616:SPERT ^@ http://purl.uniprot.org/uniprot/A0A5F8GB10|||http://purl.uniprot.org/uniprot/A0A5F8H672|||http://purl.uniprot.org/uniprot/A0A5F8H9W8|||http://purl.uniprot.org/uniprot/A0A5F8HFR0|||http://purl.uniprot.org/uniprot/F7D0F1 ^@ Similarity|||Subunit ^@ Belongs to the chibby family. SPERT subfamily.|||Homodimer. Binds to NEK1. http://togogenome.org/gene/13616:LOC100016977 ^@ http://purl.uniprot.org/uniprot/F6ZTZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RIC8B ^@ http://purl.uniprot.org/uniprot/F7AMT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/13616:LOC100011677 ^@ http://purl.uniprot.org/uniprot/F6YDH0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/13616:PIGH ^@ http://purl.uniprot.org/uniprot/A0A5F8G8T6 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/13616:SGK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ56|||http://purl.uniprot.org/uniprot/A0A5F8HJ36|||http://purl.uniprot.org/uniprot/F7F0V9 ^@ Similarity ^@ Belongs to the protein kinase superfamily.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/13616:MTHFS ^@ http://purl.uniprot.org/uniprot/F6SFK7 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/13616:GNPNAT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFP4 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family. GNA1 subfamily.|||Homodimer. http://togogenome.org/gene/13616:TMEM205 ^@ http://purl.uniprot.org/uniprot/F7FGV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM205 family.|||Membrane http://togogenome.org/gene/13616:BDNF ^@ http://purl.uniprot.org/uniprot/F7B7D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NGF-beta family.|||During development, promotes the survival and differentiation of selected neuronal populations of the peripheral and central nervous systems. Participates in axonal growth, pathfinding and in the modulation of dendritic growth and morphology. Major regulator of synaptic transmission and plasticity at adult synapses in many regions of the CNS.|||Monomers and homodimers. Binds to NTRK2/TRKB.|||Secreted http://togogenome.org/gene/13616:LOC100011383 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDX1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:ST8SIA3 ^@ http://purl.uniprot.org/uniprot/F7AQF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:CXXC1 ^@ http://purl.uniprot.org/uniprot/F6YRK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100022649 ^@ http://purl.uniprot.org/uniprot/F7DXU6 ^@ Function|||Similarity ^@ Belongs to the calmodulin family.|||May be involved in calcium-mediated signal transduction. http://togogenome.org/gene/13616:TAF4B ^@ http://purl.uniprot.org/uniprot/F7FSG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/13616:NSRP1 ^@ http://purl.uniprot.org/uniprot/F6VV70 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/13616:PGAP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5H8|||http://purl.uniprot.org/uniprot/A0A5F8GR43|||http://purl.uniprot.org/uniprot/A0A5F8HKL2|||http://purl.uniprot.org/uniprot/F7DD76 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:RCAN3 ^@ http://purl.uniprot.org/uniprot/F7EXQ5 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/13616:MFN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXF5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:TRNT1 ^@ http://purl.uniprot.org/uniprot/F6W967 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/13616:MRPS11 ^@ http://purl.uniprot.org/uniprot/F6Y8U7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/13616:LOC100024704 ^@ http://purl.uniprot.org/uniprot/A0A5F8H075|||http://purl.uniprot.org/uniprot/F6RFU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/13616:KIFC2 ^@ http://purl.uniprot.org/uniprot/F7EP41 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:RPSA ^@ http://purl.uniprot.org/uniprot/F7BC17 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK. The mature dimeric form interacts with PPP1R16B (via its fourth ankyrin repeat). Interacts with PPP1CA only in the presence of PPP1R16B.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis. Also acts as a receptor for several other ligands, including the pathogenic prion protein, viruses, and bacteria. Acts as a PPP1R16B-dependent substrate of PPP1CA.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/13616:PRKCDBP ^@ http://purl.uniprot.org/uniprot/F7FD45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/13616:NAXD ^@ http://purl.uniprot.org/uniprot/F6R5B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Mitochondrion http://togogenome.org/gene/13616:FAM198A ^@ http://purl.uniprot.org/uniprot/F6U3V1 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/13616:EARS2 ^@ http://purl.uniprot.org/uniprot/F7CD53 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/13616:ANTXR2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLH9|||http://purl.uniprot.org/uniprot/F6S811 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/13616:SIN3A ^@ http://purl.uniprot.org/uniprot/F7BFR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PET117 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/13616:PRMT7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/13616:LOC100022664 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBE7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100020362 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9D4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC25A51 ^@ http://purl.uniprot.org/uniprot/F7BG29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100022548 ^@ http://purl.uniprot.org/uniprot/F6SPP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CLIC6 ^@ http://purl.uniprot.org/uniprot/F6VJL1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/13616:LOC100032458 ^@ http://purl.uniprot.org/uniprot/F6SWW7|||http://purl.uniprot.org/uniprot/F6ZMQ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CLIC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/13616:MEF2B ^@ http://purl.uniprot.org/uniprot/F6VEY3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100617288 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:AGA ^@ http://purl.uniprot.org/uniprot/F6YVD7 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/13616:CUBN ^@ http://purl.uniprot.org/uniprot/F6UUU8 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:NLK ^@ http://purl.uniprot.org/uniprot/F6RE45 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/13616:LOC100012766 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FLCN ^@ http://purl.uniprot.org/uniprot/F6QGD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/13616:P4HA3 ^@ http://purl.uniprot.org/uniprot/F6YZ60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:THOC7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWF8|||http://purl.uniprot.org/uniprot/F6Q3G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC7 family.|||Nucleus|||Required for efficient export of polyadenylated RNA. Acts as component of the THO subcomplex of the TREX complex which is thought to couple mRNA transcription, processing and nuclear export, and which specifically associates with spliced mRNA and not with unspliced pre-mRNA. TREX is recruited to spliced mRNAs by a transcription-independent mechanism, binds to mRNA upstream of the exon-junction complex (EJC) and is recruited in a splicing- and cap-dependent manner to a region near the 5' end of the mRNA where it functions in mRNA export to the cytoplasm via the TAP/NFX1 pathway. http://togogenome.org/gene/13616:PSMB3 ^@ http://purl.uniprot.org/uniprot/F6S2Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MAPRE3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/13616:DGKI ^@ http://purl.uniprot.org/uniprot/A0A5F8HIF8 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/13616:AMPD3 ^@ http://purl.uniprot.org/uniprot/F7E5A8 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/13616:MRPL17 ^@ http://purl.uniprot.org/uniprot/F6Q774 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/13616:LOC100026015 ^@ http://purl.uniprot.org/uniprot/F7D5P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDE3A ^@ http://purl.uniprot.org/uniprot/F6YIK3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:SCTR ^@ http://purl.uniprot.org/uniprot/F6R8T5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A5F8GY28|||http://purl.uniprot.org/uniprot/F7FL62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADGRB1 ^@ http://purl.uniprot.org/uniprot/F6TRV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ARL14 ^@ http://purl.uniprot.org/uniprot/F6XV63 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:SLC25A43 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100013511 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:MIEF1 ^@ http://purl.uniprot.org/uniprot/K7E2U5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:CPXM2 ^@ http://purl.uniprot.org/uniprot/F6YX02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/13616:LOC100026279 ^@ http://purl.uniprot.org/uniprot/F7A8G2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:USP2 ^@ http://purl.uniprot.org/uniprot/F7EVY5 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:LOC100028903 ^@ http://purl.uniprot.org/uniprot/F6T1N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/13616:CDC25A ^@ http://purl.uniprot.org/uniprot/F6W4M4 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/13616:REEP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/13616:LOC100017350 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHU6|||http://purl.uniprot.org/uniprot/A0A5F8H925 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FBXO9 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7V7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:SPTSSA ^@ http://purl.uniprot.org/uniprot/A0A5F8GDX5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:ABI2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G218|||http://purl.uniprot.org/uniprot/A0A5F8GEI6|||http://purl.uniprot.org/uniprot/A0A5F8H605|||http://purl.uniprot.org/uniprot/A0A5F8H9W6|||http://purl.uniprot.org/uniprot/A0A5F8HCI5|||http://purl.uniprot.org/uniprot/F7AYN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/13616:CNTN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEE1|||http://purl.uniprot.org/uniprot/F7C9P7 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/13616:USO1 ^@ http://purl.uniprot.org/uniprot/F7EP84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/13616:GLYATL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQX4 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/13616:FBL ^@ http://purl.uniprot.org/uniprot/F6QP22 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/13616:ADRM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100029519 ^@ http://purl.uniprot.org/uniprot/F6YBH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase that catalyzes the side-chain hydroxylation and cleavage of cholesterol to pregnenolone, the precursor of most steroid hormones. Catalyzes three sequential oxidation reactions of cholesterol, namely the hydroxylation at C22 followed with the hydroxylation at C20 to yield 20R,22R-hydroxycholesterol that is further cleaved between C20 and C22 to yield the C21-steroid pregnenolone and 4-methylpentanal. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate and reducing the second into a water molecule. Two electrons are provided by NADPH via a two-protein mitochondrial transfer system comprising flavoprotein FDXR (adrenodoxin/ferredoxin reductase) and nonheme iron-sulfur protein FDX1 or FDX2 (adrenodoxin/ferredoxin).|||Belongs to the cytochrome P450 family.|||Interacts with FDX1/adrenodoxin.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:MTX2 ^@ http://purl.uniprot.org/uniprot/F6RZY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:CYR61 ^@ http://purl.uniprot.org/uniprot/F6WAV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LIPG ^@ http://purl.uniprot.org/uniprot/F7G148 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:TET2 ^@ http://purl.uniprot.org/uniprot/F7FXD1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/13616:VN2R616 ^@ http://purl.uniprot.org/uniprot/F7D5Q1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ENPP3 ^@ http://purl.uniprot.org/uniprot/F7BSG0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:LOC100013297 ^@ http://purl.uniprot.org/uniprot/F6RS65 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/13616:IL17F ^@ http://purl.uniprot.org/uniprot/F6YYQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-17 family.|||Secreted http://togogenome.org/gene/13616:KPNA2 ^@ http://purl.uniprot.org/uniprot/F7D853 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:NDUFS4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:NID1 ^@ http://purl.uniprot.org/uniprot/F7FV41 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/13616:LOC100026938 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SLITRK5 ^@ http://purl.uniprot.org/uniprot/F6TF48 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:TBX18 ^@ http://purl.uniprot.org/uniprot/F6PPW8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:CRYAA ^@ http://purl.uniprot.org/uniprot/F6QYV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/13616:B4GALNT3 ^@ http://purl.uniprot.org/uniprot/F7DVM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/13616:TSEN34 ^@ http://purl.uniprot.org/uniprot/F7F900 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/13616:LOC100022273 ^@ http://purl.uniprot.org/uniprot/F7EJ94 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:SCRN2 ^@ http://purl.uniprot.org/uniprot/F6Q4M9 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/13616:GLS2 ^@ http://purl.uniprot.org/uniprot/F6QBQ6 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/13616:SAE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G607|||http://purl.uniprot.org/uniprot/F7GCP9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/13616:TMEM151B ^@ http://purl.uniprot.org/uniprot/A0A5F8H4D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/13616:VN2R593 ^@ http://purl.uniprot.org/uniprot/F7AZ05 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PGF ^@ http://purl.uniprot.org/uniprot/F7FF03 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/13616:ACADL ^@ http://purl.uniprot.org/uniprot/F7FE37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/13616:LOC100016236 ^@ http://purl.uniprot.org/uniprot/F6RQ67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:KIF3C ^@ http://purl.uniprot.org/uniprot/F7FDX1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:SLITRK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8J4 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:MIPEP ^@ http://purl.uniprot.org/uniprot/F7G4C7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/13616:RELT ^@ http://purl.uniprot.org/uniprot/F7BLC2 ^@ Caution|||Similarity ^@ Belongs to the RELT family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC103093231 ^@ http://purl.uniprot.org/uniprot/A0A5F8H499|||http://purl.uniprot.org/uniprot/F7EY06 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/13616:PLIN1 ^@ http://purl.uniprot.org/uniprot/F7B2B5 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/13616:ASF1A ^@ http://purl.uniprot.org/uniprot/A0A5F8H323 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/13616:PCMTD1 ^@ http://purl.uniprot.org/uniprot/F6QTB4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/13616:VPS33A ^@ http://purl.uniprot.org/uniprot/F7CE04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/13616:FOXJ1 ^@ http://purl.uniprot.org/uniprot/F7FGZ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100020089 ^@ http://purl.uniprot.org/uniprot/F7DCB3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/13616:LOC103099055 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG72 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GPR6 ^@ http://purl.uniprot.org/uniprot/F6TRX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:USP10 ^@ http://purl.uniprot.org/uniprot/F6Y299 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP10 subfamily.|||Cytoplasm|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Nucleus http://togogenome.org/gene/13616:DDB2 ^@ http://purl.uniprot.org/uniprot/F6VQA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Nucleus http://togogenome.org/gene/13616:CHRM3 ^@ http://purl.uniprot.org/uniprot/F6XBA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/13616:FUCA2 ^@ http://purl.uniprot.org/uniprot/F6TJX9 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/13616:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSJ4|||http://purl.uniprot.org/uniprot/F7GLV8 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/13616:LOC100018515 ^@ http://purl.uniprot.org/uniprot/F6TIV9 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/13616:DYM ^@ http://purl.uniprot.org/uniprot/A0A5F8HJW0|||http://purl.uniprot.org/uniprot/F7C8I3 ^@ Similarity ^@ Belongs to the dymeclin family. http://togogenome.org/gene/13616:PRRT1 ^@ http://purl.uniprot.org/uniprot/F7G653 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/13616:CDCA7 ^@ http://purl.uniprot.org/uniprot/F7ADY5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MARCH11 ^@ http://purl.uniprot.org/uniprot/F7DWW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:VAMP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDE0|||http://purl.uniprot.org/uniprot/F7A943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:MPC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G967 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:AHCYL1 ^@ http://purl.uniprot.org/uniprot/F6T5I3 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/13616:MINOS1 ^@ http://purl.uniprot.org/uniprot/F7FLC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LIPH ^@ http://purl.uniprot.org/uniprot/F6Z6X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:EXTL2 ^@ http://purl.uniprot.org/uniprot/F7DWS0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:AP3M1 ^@ http://purl.uniprot.org/uniprot/F6VQ35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/13616:LOC100029952 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKJ6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:LOC100029725 ^@ http://purl.uniprot.org/uniprot/F6UHH2 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/13616:ANKRD34A ^@ http://purl.uniprot.org/uniprot/F7EF13 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/13616:SEMA4G ^@ http://purl.uniprot.org/uniprot/F7B995 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SVOPL ^@ http://purl.uniprot.org/uniprot/A0A5F8GK35|||http://purl.uniprot.org/uniprot/F6SXC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SLC26A7 ^@ http://purl.uniprot.org/uniprot/F7GJR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/13616:NDST2 ^@ http://purl.uniprot.org/uniprot/F6VAE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/13616:MGST2 ^@ http://purl.uniprot.org/uniprot/F6V226 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:IPO7 ^@ http://purl.uniprot.org/uniprot/F7ETD3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:DPF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE84|||http://purl.uniprot.org/uniprot/A0A5F8GFT4|||http://purl.uniprot.org/uniprot/A0A5F8GGJ7|||http://purl.uniprot.org/uniprot/K7DYZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the requiem/DPF family.|||Nucleus http://togogenome.org/gene/13616:LOC100025981 ^@ http://purl.uniprot.org/uniprot/F7AIL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/13616:LOC100618817 ^@ http://purl.uniprot.org/uniprot/F6YMJ4 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:RAD23A ^@ http://purl.uniprot.org/uniprot/A0A5F8G8H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/13616:MOGS ^@ http://purl.uniprot.org/uniprot/F7FL90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:FZD4 ^@ http://purl.uniprot.org/uniprot/F6VFD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/13616:CALU ^@ http://purl.uniprot.org/uniprot/A0A5F8HD09|||http://purl.uniprot.org/uniprot/F7F3R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Endoplasmic reticulum membrane|||Golgi apparatus|||Melanosome|||Membrane|||Sarcoplasmic reticulum lumen|||Secreted http://togogenome.org/gene/13616:CCR10 ^@ http://purl.uniprot.org/uniprot/F7CG75 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:IL18R1 ^@ http://purl.uniprot.org/uniprot/F7F019 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/13616:KCNMB4 ^@ http://purl.uniprot.org/uniprot/F7C066 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KCNMB (TC 8.A.14.1) family.|||Interacts with KCNMA1 tetramer. There are probably 4 molecules of KCMNB per KCNMA1 tetramer.|||Membrane|||N-glycosylated.|||Regulatory subunit of the calcium activated potassium KCNMA1 (maxiK) channel. Modulates the calcium sensitivity and gating kinetics of KCNMA1, thereby contributing to KCNMA1 channel diversity. http://togogenome.org/gene/13616:LOC100021023 ^@ http://purl.uniprot.org/uniprot/F6RPE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ARSE ^@ http://purl.uniprot.org/uniprot/K7E4E2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:SNX18 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/13616:PPP1R1C ^@ http://purl.uniprot.org/uniprot/F6ZGY0 ^@ Similarity ^@ Belongs to the protein phosphatase inhibitor 1 family. http://togogenome.org/gene/13616:COG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVG9 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/13616:SSRP1 ^@ http://purl.uniprot.org/uniprot/F7ESR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/13616:KIT ^@ http://purl.uniprot.org/uniprot/F7A906 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100030289 ^@ http://purl.uniprot.org/uniprot/F7CGB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SMIM15 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/13616:LYG1 ^@ http://purl.uniprot.org/uniprot/F7FWA7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 23 family. http://togogenome.org/gene/13616:RDH10 ^@ http://purl.uniprot.org/uniprot/F6SH88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:LOC100030370 ^@ http://purl.uniprot.org/uniprot/F6W6I4 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/13616:RER1 ^@ http://purl.uniprot.org/uniprot/F7G5H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/13616:LOC100027344 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5G3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:TCEB3 ^@ http://purl.uniprot.org/uniprot/F7CT40 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC10A6 ^@ http://purl.uniprot.org/uniprot/F6ZZW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/13616:IDH1 ^@ http://purl.uniprot.org/uniprot/F6ZQM3 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/13616:LOC100029949 ^@ http://purl.uniprot.org/uniprot/F7FSJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PLIN4 ^@ http://purl.uniprot.org/uniprot/F7DNE7 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/13616:LOC100617751 ^@ http://purl.uniprot.org/uniprot/F7ENP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/13616:PSME2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ15 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/13616:ARL9 ^@ http://purl.uniprot.org/uniprot/F7D1G1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:TACR3 ^@ http://purl.uniprot.org/uniprot/F7E6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PRDX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H055 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/13616:LOC100013717 ^@ http://purl.uniprot.org/uniprot/F7BFQ5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:LIX1L ^@ http://purl.uniprot.org/uniprot/F7EF18 ^@ Similarity ^@ Belongs to the LIX1 family. http://togogenome.org/gene/13616:RPL27A ^@ http://purl.uniprot.org/uniprot/A0A5F8GDJ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/13616:CHST2 ^@ http://purl.uniprot.org/uniprot/F6TJG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/13616:TRPM6 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBL9|||http://purl.uniprot.org/uniprot/F6QWI3 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100012604 ^@ http://purl.uniprot.org/uniprot/Q9XT87 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31.|||ISGylated.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). http://togogenome.org/gene/13616:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM01|||http://purl.uniprot.org/uniprot/A0A5F8GVL7 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/13616:ACTR1A ^@ http://purl.uniprot.org/uniprot/F6R1W9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:LOC100014492 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/13616:LOC100021976 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6Z3|||http://purl.uniprot.org/uniprot/F6VJA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/13616:RHO ^@ http://purl.uniprot.org/uniprot/F7F2J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/13616:FES ^@ http://purl.uniprot.org/uniprot/F6RWR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fes/fps subfamily.|||Cell membrane|||cytoskeleton http://togogenome.org/gene/13616:FOXD1 ^@ http://purl.uniprot.org/uniprot/K7E090 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC44A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFL5|||http://purl.uniprot.org/uniprot/F6RTY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/13616:LOC100011004 ^@ http://purl.uniprot.org/uniprot/F7E6D6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family.|||Membrane|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:SLC2A4 ^@ http://purl.uniprot.org/uniprot/F7G424 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. Glucose transporter subfamily.|||Cell membrane|||Endomembrane system|||Membrane|||perinuclear region http://togogenome.org/gene/13616:CCNG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G212 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/13616:IMMP2L ^@ http://purl.uniprot.org/uniprot/F7GH07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/E4ZFH5|||http://purl.uniprot.org/uniprot/F7G4K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:CIAO1 ^@ http://purl.uniprot.org/uniprot/F7F2Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Component of the CIA complex. Component of the MMXD complex, which includes CIAO1, ERCC2, FAM96B, MMS19 and SLC25A5. Interacts with WT1. Interacts with FAM96A.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into extramitochondrial Fe/S proteins. Seems to specifically modulate the transactivation activity of WT1. As part of the mitotic spindle-associated MMXD complex it may play a role in chromosome segregation. http://togogenome.org/gene/13616:RPL18A ^@ http://purl.uniprot.org/uniprot/A0A5F8H1R7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/13616:ITFG1 ^@ http://purl.uniprot.org/uniprot/F6ZNY3 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/13616:PTN ^@ http://purl.uniprot.org/uniprot/F6VS98 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/13616:PCOLCE2 ^@ http://purl.uniprot.org/uniprot/F6TZS0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LRP12 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8W0|||http://purl.uniprot.org/uniprot/F7FVQ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VSX2 ^@ http://purl.uniprot.org/uniprot/F7GCQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MMS19 ^@ http://purl.uniprot.org/uniprot/F6VF05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MET18/MMS19 family.|||Component of the CIA complex.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus|||spindle http://togogenome.org/gene/13616:SLC11A2 ^@ http://purl.uniprot.org/uniprot/F7EQK8 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/13616:HMCES ^@ http://purl.uniprot.org/uniprot/F7E4W2 ^@ Function|||Similarity ^@ Belongs to the SOS response-associated peptidase family.|||Sensor of abasic sites in single-stranded DNA (ssDNA) required to preserve genome integrity by promoting error-free repair of abasic sites. Acts as an enzyme that recognizes and binds abasic sites in ssDNA at replication forks and chemically modifies the lesion by forming a covalent cross-link with DNA: forms a stable thiazolidine linkage between a ring-opened abasic site and the alpha-amino and sulfhydryl substituents of its N-terminal catalytic cysteine residue. The HMCES DNA-protein cross-link is then degraded by the proteasome. Promotes error-free repair of abasic sites by acting as a 'suicide' enzyme that is degraded, thereby protecting abasic sites from translesion synthesis (TLS) polymerases and endonucleases that are error-prone and would generate mutations and double-strand breaks. Has preference for ssDNA, but can also accommodate double-stranded DNA with 3' or 5' overhang (dsDNA), and dsDNA-ssDNA 3' junction. http://togogenome.org/gene/13616:ENKUR ^@ http://purl.uniprot.org/uniprot/A0A5F8GY05|||http://purl.uniprot.org/uniprot/F6PUB7 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/13616:SURF1 ^@ http://purl.uniprot.org/uniprot/F6SJG1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100617279 ^@ http://purl.uniprot.org/uniprot/F7D6E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RAB27B ^@ http://purl.uniprot.org/uniprot/A0A5F8GU64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/13616:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6U3|||http://purl.uniprot.org/uniprot/F6WW16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:LOC100018100 ^@ http://purl.uniprot.org/uniprot/F7FPL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:LOC100028170 ^@ http://purl.uniprot.org/uniprot/A0A5F8G805 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031169 ^@ http://purl.uniprot.org/uniprot/F7E1H0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:ARL5A ^@ http://purl.uniprot.org/uniprot/F7FMD0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:EXOC3 ^@ http://purl.uniprot.org/uniprot/F6SBJ3 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/13616:BLK ^@ http://purl.uniprot.org/uniprot/F7B9H2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:DLGAP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G958|||http://purl.uniprot.org/uniprot/F7BCR7 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/13616:FAM214A ^@ http://purl.uniprot.org/uniprot/F6T5P8 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/13616:CEP70 ^@ http://purl.uniprot.org/uniprot/F7FRD6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Directly interacts with tubulin-gamma; this interaction determines centrosomal localization.|||Plays a role in the organization of both preexisting and nascent microtubules in interphase cells. During mitosis, required for the organization and orientation of the mitotic spindle.|||centrosome http://togogenome.org/gene/13616:ANTXR1 ^@ http://purl.uniprot.org/uniprot/F7CVU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/13616:KIF22 ^@ http://purl.uniprot.org/uniprot/F6PIR6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:HCAR1 ^@ http://purl.uniprot.org/uniprot/F7EJ84 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:NOG ^@ http://purl.uniprot.org/uniprot/F7D2A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the noggin family.|||Homodimer.|||Inhibitor of bone morphogenetic proteins (BMP) signaling which is required for growth and patterning of the neural tube and somite.|||Secreted http://togogenome.org/gene/13616:KIF11 ^@ http://purl.uniprot.org/uniprot/K7E5Q0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:LOC100025428 ^@ http://purl.uniprot.org/uniprot/F6YZY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ARL5B ^@ http://purl.uniprot.org/uniprot/F7FZL7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:UBE2B ^@ http://purl.uniprot.org/uniprot/F6TQE0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:CHST7 ^@ http://purl.uniprot.org/uniprot/F7AP75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/13616:SCARB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9T3|||http://purl.uniprot.org/uniprot/A0A5F8G9U5|||http://purl.uniprot.org/uniprot/A0A5F8HKB3 ^@ Similarity ^@ Belongs to the CD36 family. http://togogenome.org/gene/13616:PPL ^@ http://purl.uniprot.org/uniprot/F6ZU67 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:DDX47 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9W9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/13616:PLPP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBD0|||http://purl.uniprot.org/uniprot/F6VUV1 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/13616:LOC100019591 ^@ http://purl.uniprot.org/uniprot/F6Z4Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100011978 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZV0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100017088 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:SLC30A9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK31|||http://purl.uniprot.org/uniprot/A0A5F8GUE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Cytoplasmic vesicle|||Endoplasmic reticulum|||Membrane|||Nucleus|||Vesicle http://togogenome.org/gene/13616:HOXA2 ^@ http://purl.uniprot.org/uniprot/F6TU52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC103100274 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SIAH3 ^@ http://purl.uniprot.org/uniprot/K7E4P4 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/13616:CDH19 ^@ http://purl.uniprot.org/uniprot/F7CBY6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCY0|||http://purl.uniprot.org/uniprot/F6ZGZ5 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/13616:ASTE1 ^@ http://purl.uniprot.org/uniprot/F7E008 ^@ Similarity ^@ Belongs to the asteroid family. http://togogenome.org/gene/13616:GATA5 ^@ http://purl.uniprot.org/uniprot/F7GG55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DEF8 ^@ http://purl.uniprot.org/uniprot/F7CTD5 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/13616:TBX2 ^@ http://purl.uniprot.org/uniprot/F6TQY6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:PITX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/13616:MAPK1 ^@ http://purl.uniprot.org/uniprot/F7FHD1 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||caveola http://togogenome.org/gene/13616:MEGF11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGU8|||http://purl.uniprot.org/uniprot/A0A5F8GUM3|||http://purl.uniprot.org/uniprot/A0A5F8HC26|||http://purl.uniprot.org/uniprot/F6SYX8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NDUFV3 ^@ http://purl.uniprot.org/uniprot/F6QYY9 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/13616:ARPP19 ^@ http://purl.uniprot.org/uniprot/F6T5G5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/13616:BMS1 ^@ http://purl.uniprot.org/uniprot/F7GHE4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:SPON1 ^@ http://purl.uniprot.org/uniprot/F7EHN2 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/13616:AGTPBP1 ^@ http://purl.uniprot.org/uniprot/F7DJ39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/13616:FGF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPQ2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:MAT1A ^@ http://purl.uniprot.org/uniprot/F7F413 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/13616:TMLHE ^@ http://purl.uniprot.org/uniprot/F7E1P0 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/13616:JAGN1 ^@ http://purl.uniprot.org/uniprot/F6ZCG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:MYH9 ^@ http://purl.uniprot.org/uniprot/F7GHW6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:LOC100029547 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN39 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/13616:SAXO1 ^@ http://purl.uniprot.org/uniprot/F7E7K9 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/13616:JAKMIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H447 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/13616:LOC100617796 ^@ http://purl.uniprot.org/uniprot/F7EB92 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CLVS2 ^@ http://purl.uniprot.org/uniprot/F7ELG1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/13616:SOX3 ^@ http://purl.uniprot.org/uniprot/F6SCS3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PSMG2 ^@ http://purl.uniprot.org/uniprot/F7CBG6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/13616:LOC100010054 ^@ http://purl.uniprot.org/uniprot/F7EIS0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:TOM1L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDB9|||http://purl.uniprot.org/uniprot/F7BYB8 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/13616:VAMP3 ^@ http://purl.uniprot.org/uniprot/F7G4F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/13616:CTC1 ^@ http://purl.uniprot.org/uniprot/F7EB97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CTC1 family.|||Nucleus|||telomere http://togogenome.org/gene/13616:LOC100028614 ^@ http://purl.uniprot.org/uniprot/F7CZ01 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/13616:C3H19orf66 ^@ http://purl.uniprot.org/uniprot/F7F5S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHFL family.|||Nucleus|||P-body http://togogenome.org/gene/13616:TADA3 ^@ http://purl.uniprot.org/uniprot/F7EQN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/13616:C3H8orf22 ^@ http://purl.uniprot.org/uniprot/K7E023 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/13616:LOC100020922 ^@ http://purl.uniprot.org/uniprot/F6STH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:HNRNPDL ^@ http://purl.uniprot.org/uniprot/A0A5F8GV62|||http://purl.uniprot.org/uniprot/F7E028 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:RPS12 ^@ http://purl.uniprot.org/uniprot/F7EIJ4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/13616:FOXB1 ^@ http://purl.uniprot.org/uniprot/F6XBS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PLA2G2C ^@ http://purl.uniprot.org/uniprot/A0A5F8GYW1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/13616:LOC100024341 ^@ http://purl.uniprot.org/uniprot/F6U5A9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/13616:SIM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLB5|||http://purl.uniprot.org/uniprot/F6Z9V8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BMP5 ^@ http://purl.uniprot.org/uniprot/F7AD87 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:GINS2 ^@ http://purl.uniprot.org/uniprot/F6Y4K0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/13616:WDFY2 ^@ http://purl.uniprot.org/uniprot/F7D654 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:SKA3 ^@ http://purl.uniprot.org/uniprot/K7DZ58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA3 family.|||kinetochore|||spindle http://togogenome.org/gene/13616:SLC27A1 ^@ http://purl.uniprot.org/uniprot/F6SCF1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:SHMT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF15 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/13616:LOC100012393 ^@ http://purl.uniprot.org/uniprot/F7BX40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A5F8H7B2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100619985 ^@ http://purl.uniprot.org/uniprot/F6Z5E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TERF1 ^@ http://purl.uniprot.org/uniprot/F6XW10 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Binds the telomeric double-stranded 5'-TTAGGG-3' repeat.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/13616:LOC100030424 ^@ http://purl.uniprot.org/uniprot/F7GKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TIMP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G917 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||Interacts with EFEMP1.|||extracellular matrix http://togogenome.org/gene/13616:THUMPD3 ^@ http://purl.uniprot.org/uniprot/F6QGW7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/13616:LOC100025995 ^@ http://purl.uniprot.org/uniprot/F6SJQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:RHAG ^@ http://purl.uniprot.org/uniprot/F6Z2B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/13616:KIF5B ^@ http://purl.uniprot.org/uniprot/F7BJ22 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:IDS ^@ http://purl.uniprot.org/uniprot/F7DJA1 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:LOC100022274 ^@ http://purl.uniprot.org/uniprot/F6Q040 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GINS3 ^@ http://purl.uniprot.org/uniprot/F7GKR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/13616:AHSA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWY2 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/13616:ITGA1 ^@ http://purl.uniprot.org/uniprot/F6RXG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:SYPL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSS2|||http://purl.uniprot.org/uniprot/A0A5F8HAB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/13616:monDomV1R1240 ^@ http://purl.uniprot.org/uniprot/A0A5F8H930 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MAML1 ^@ http://purl.uniprot.org/uniprot/F7GAC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mastermind family.|||Nucleus speckle http://togogenome.org/gene/13616:CSK ^@ http://purl.uniprot.org/uniprot/F7GJZ7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:LOC100024324 ^@ http://purl.uniprot.org/uniprot/F7EID0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EGFL7 ^@ http://purl.uniprot.org/uniprot/F7AHX7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:POLA1 ^@ http://purl.uniprot.org/uniprot/F7ADS9 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/13616:ADAMTS18 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1Q7 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:T2R2 ^@ http://purl.uniprot.org/uniprot/Q2ABA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:TTYH2 ^@ http://purl.uniprot.org/uniprot/F7DGW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tweety family.|||Cell membrane|||Membrane|||Probable chloride channel. http://togogenome.org/gene/13616:VN2R527 ^@ http://purl.uniprot.org/uniprot/F7EB70 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100024120 ^@ http://purl.uniprot.org/uniprot/F7GBZ1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LEO1 ^@ http://purl.uniprot.org/uniprot/F6RIH3 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/13616:SELL ^@ http://purl.uniprot.org/uniprot/F6VGS6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:CTLA4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRC7|||http://purl.uniprot.org/uniprot/F7FLL7 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/13616:LOC100015398 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP03 ^@ Function|||Similarity ^@ Belongs to the metallothionein superfamily. Type 1 family.|||Metallothioneins have a high content of cysteine residues that bind various heavy metals. http://togogenome.org/gene/13616:LOC100022370 ^@ http://purl.uniprot.org/uniprot/F6Q066 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SBNO2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXV2|||http://purl.uniprot.org/uniprot/A0A5F8HHS8|||http://purl.uniprot.org/uniprot/F7GGH7 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/13616:LOC103097229 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8Y8|||http://purl.uniprot.org/uniprot/K7E577 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/13616:RGMB ^@ http://purl.uniprot.org/uniprot/F6YFP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0S4|||http://purl.uniprot.org/uniprot/F6STR1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ARF4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/13616:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane|||Plays a role as pro-apoptotic protein that induces caspase-dependent apoptosis. http://togogenome.org/gene/13616:SLC16A4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7G5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DDX5 ^@ http://purl.uniprot.org/uniprot/F7ECU0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/13616:SMAD1 ^@ http://purl.uniprot.org/uniprot/F6TU68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DIS3 ^@ http://purl.uniprot.org/uniprot/F6TF04 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/13616:DPY19L4 ^@ http://purl.uniprot.org/uniprot/F6RDC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/13616:TM4SF18 ^@ http://purl.uniprot.org/uniprot/F6T389 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/13616:PAQR3 ^@ http://purl.uniprot.org/uniprot/F6S7C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:TAGLN3 ^@ http://purl.uniprot.org/uniprot/F7FFS3 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/13616:VN2R560 ^@ http://purl.uniprot.org/uniprot/A0A5F8G747 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:DCK ^@ http://purl.uniprot.org/uniprot/F7FN05 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/13616:FAM53A ^@ http://purl.uniprot.org/uniprot/F6X726 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/13616:BRE ^@ http://purl.uniprot.org/uniprot/A0A5F8GMC4|||http://purl.uniprot.org/uniprot/F6ZV60 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/13616:VPS33B ^@ http://purl.uniprot.org/uniprot/F6VUT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||clathrin-coated vesicle http://togogenome.org/gene/13616:NUP98 ^@ http://purl.uniprot.org/uniprot/F7FTZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/13616:TCTEX1D2 ^@ http://purl.uniprot.org/uniprot/F6UIA1 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/13616:LOC103105270 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Secreted http://togogenome.org/gene/13616:LOC103092739 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWY8 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/13616:PARVA ^@ http://purl.uniprot.org/uniprot/F7CCU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||cytoskeleton http://togogenome.org/gene/13616:RPL10A ^@ http://purl.uniprot.org/uniprot/F6UB55 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/13616:monDomV1R1224 ^@ http://purl.uniprot.org/uniprot/F7E1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CTTNBP2 ^@ http://purl.uniprot.org/uniprot/F7AH12 ^@ Subcellular Location Annotation ^@ cell cortex|||dendritic spine http://togogenome.org/gene/13616:GAL3ST2 ^@ http://purl.uniprot.org/uniprot/F6PHE0 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/13616:C1H9orf116 ^@ http://purl.uniprot.org/uniprot/F6VAZ1 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CFAP53, ODAD1 and ODAD3; the interactions link the outer dynein arms docking complex (ODA-DC) to the internal microtubule inner proteins (MIP) in cilium axoneme.|||cilium axoneme http://togogenome.org/gene/13616:PYGB ^@ http://purl.uniprot.org/uniprot/A0A5F8GST0|||http://purl.uniprot.org/uniprot/F7EZJ9 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/13616:PLA2G1B ^@ http://purl.uniprot.org/uniprot/F6VFV8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/13616:MKNK1 ^@ http://purl.uniprot.org/uniprot/F6VJP3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:DLX3 ^@ http://purl.uniprot.org/uniprot/F7G4K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the distal-less homeobox family.|||Nucleus http://togogenome.org/gene/13616:WDR12 ^@ http://purl.uniprot.org/uniprot/F7BGQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:EED ^@ http://purl.uniprot.org/uniprot/F6TW64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ESC family.|||Nucleus http://togogenome.org/gene/13616:MFAP3L ^@ http://purl.uniprot.org/uniprot/F6PP60 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AGPAT5 ^@ http://purl.uniprot.org/uniprot/F7G4Z7 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:TMEM163 ^@ http://purl.uniprot.org/uniprot/F6WLI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Early endosome membrane|||Endosome membrane|||May bind zinc and other divalent cations and recruit them to vesicular organelles.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:ATP5J ^@ http://purl.uniprot.org/uniprot/F6QZT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ATPase subunit F6 family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements. Also involved in the restoration of oligomycin-sensitive ATPase activity to depleted F1-F0 complexes.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SLC1A5 ^@ http://purl.uniprot.org/uniprot/F6QQG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/13616:RDH8 ^@ http://purl.uniprot.org/uniprot/F7ERI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/13616:NPM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN07|||http://purl.uniprot.org/uniprot/F7D8H7 ^@ Similarity ^@ Belongs to the nucleoplasmin family. http://togogenome.org/gene/13616:ECH1 ^@ http://purl.uniprot.org/uniprot/F6ZM87 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/13616:TET1 ^@ http://purl.uniprot.org/uniprot/F6XCP8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/13616:SLC2A6 ^@ http://purl.uniprot.org/uniprot/F7CS72 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/13616:HSPA5 ^@ http://purl.uniprot.org/uniprot/F6WMM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:CACNG3 ^@ http://purl.uniprot.org/uniprot/F7A5K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane http://togogenome.org/gene/13616:RGS8 ^@ http://purl.uniprot.org/uniprot/F6PX35|||http://purl.uniprot.org/uniprot/F6PX48 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Nucleus|||Perikaryon|||dendrite http://togogenome.org/gene/13616:CCDC172 ^@ http://purl.uniprot.org/uniprot/F7A9G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC172 family.|||Cytoplasm http://togogenome.org/gene/13616:HHIPL2 ^@ http://purl.uniprot.org/uniprot/F6TQQ8 ^@ Similarity ^@ Belongs to the HHIP family. http://togogenome.org/gene/13616:CMTM4 ^@ http://purl.uniprot.org/uniprot/F6PVR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:UBA7 ^@ http://purl.uniprot.org/uniprot/F6PN80 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/13616:FOLH1B ^@ http://purl.uniprot.org/uniprot/F7DHV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NXPH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZQ8|||http://purl.uniprot.org/uniprot/F7GH77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/13616:ALG11 ^@ http://purl.uniprot.org/uniprot/F7ESN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. http://togogenome.org/gene/13616:SLC25A26 ^@ http://purl.uniprot.org/uniprot/F6THA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:ATG4C ^@ http://purl.uniprot.org/uniprot/A0A5F8HLB7|||http://purl.uniprot.org/uniprot/F7FIS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/13616:ASNA1 ^@ http://purl.uniprot.org/uniprot/F6PT29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. Component of a transmembrane domain recognition complex (TRC). Interacts with SERP1 and SEC61B. Interacts with WRB.|||nucleolus http://togogenome.org/gene/13616:PPIL1 ^@ http://purl.uniprot.org/uniprot/F7F8D1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:CHAT ^@ http://purl.uniprot.org/uniprot/F7ALU3 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/13616:C4BPA ^@ http://purl.uniprot.org/uniprot/A0A5F8GCZ4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CNTNAP1 ^@ http://purl.uniprot.org/uniprot/F7BXG8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||paranodal septate junction http://togogenome.org/gene/13616:SLC25A34 ^@ http://purl.uniprot.org/uniprot/F7DWW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:UFM1 ^@ http://purl.uniprot.org/uniprot/F6Y6H3 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/13616:PENK ^@ http://purl.uniprot.org/uniprot/A0A5F8GKD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Neuropeptide that competes with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Secreted|||chromaffin granule lumen http://togogenome.org/gene/13616:COG8 ^@ http://purl.uniprot.org/uniprot/F6YGC2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG8 family.|||Component of the conserved oligomeric Golgi complex which is composed of eight different subunits and is required for normal Golgi morphology and localization.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LNPEP ^@ http://purl.uniprot.org/uniprot/F6SKQ6 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/13616:MEIS1 ^@ http://purl.uniprot.org/uniprot/F6Z0Y6|||http://purl.uniprot.org/uniprot/F7EW36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/13616:IRF4 ^@ http://purl.uniprot.org/uniprot/F7CDR0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:LOC100011913 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6Q8|||http://purl.uniprot.org/uniprot/A0A5F8HCQ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYL0|||http://purl.uniprot.org/uniprot/F7GJP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/13616:PNRC1 ^@ http://purl.uniprot.org/uniprot/F6Q6C4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC6A8 ^@ http://purl.uniprot.org/uniprot/F6Z838 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDIA2 ^@ http://purl.uniprot.org/uniprot/F7G717 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:GPR156 ^@ http://purl.uniprot.org/uniprot/F6PGM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CHRM1 ^@ http://purl.uniprot.org/uniprot/F7EL12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/13616:SUMF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:NR3C1 ^@ http://purl.uniprot.org/uniprot/F6S9Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Mitochondrion|||Nucleus|||centrosome|||spindle http://togogenome.org/gene/13616:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXD9|||http://purl.uniprot.org/uniprot/F7CTJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:TMEM9B ^@ http://purl.uniprot.org/uniprot/F7GAU1 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/13616:VN2R519 ^@ http://purl.uniprot.org/uniprot/F6ZLJ5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100026209 ^@ http://purl.uniprot.org/uniprot/F6X7L4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/13616:ACYP1 ^@ http://purl.uniprot.org/uniprot/F7AJT1 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/13616:GPAM ^@ http://purl.uniprot.org/uniprot/F6S9J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:XPO1 ^@ http://purl.uniprot.org/uniprot/F7EIW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/13616:C3H5orf63 ^@ http://purl.uniprot.org/uniprot/F7B4M0 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/13616:NPR3 ^@ http://purl.uniprot.org/uniprot/F7BZD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CLDN5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:LOC100020779 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBN7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/13616:OPN1SW ^@ http://purl.uniprot.org/uniprot/B9MSR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane|||photoreceptor outer segment http://togogenome.org/gene/13616:TTC21B ^@ http://purl.uniprot.org/uniprot/F7EKI1 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/13616:ATF4 ^@ http://purl.uniprot.org/uniprot/F7CPU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/13616:DMGDH ^@ http://purl.uniprot.org/uniprot/A0A5F8GYF8|||http://purl.uniprot.org/uniprot/F6X4T1 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/13616:LOC100020606 ^@ http://purl.uniprot.org/uniprot/F6QVX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/13616:PLPP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBS5|||http://purl.uniprot.org/uniprot/F6PGG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:FAM133B ^@ http://purl.uniprot.org/uniprot/F7FK91 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/13616:PPIL6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7X9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:ATP6V1A ^@ http://purl.uniprot.org/uniprot/F7CCX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||clathrin-coated vesicle membrane|||secretory vesicle http://togogenome.org/gene/13616:LOC100009916 ^@ http://purl.uniprot.org/uniprot/F6VTL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 11 family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:T2R40 ^@ http://purl.uniprot.org/uniprot/Q2AB87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:SVBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVBP family.|||Secreted|||cytoskeleton http://togogenome.org/gene/13616:KCND3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G682|||http://purl.uniprot.org/uniprot/F7CIE1 ^@ Subcellular Location Annotation ^@ Membrane|||dendrite http://togogenome.org/gene/13616:CNNM3 ^@ http://purl.uniprot.org/uniprot/F6YUX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ACDP family.|||Membrane http://togogenome.org/gene/13616:VARS2 ^@ http://purl.uniprot.org/uniprot/F7F0F7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:SEMA6C ^@ http://purl.uniprot.org/uniprot/F7EDV4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CLPTM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/13616:DNASE1L1 ^@ http://purl.uniprot.org/uniprot/F6RGU8 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/13616:SNRPE ^@ http://purl.uniprot.org/uniprot/K7DZR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes. Is also a component of the minor U12 spliceosome. As part of the U7 snRNP it is involved in histone 3'-end processing.|||cytosol http://togogenome.org/gene/13616:ISL1 ^@ http://purl.uniprot.org/uniprot/F6QG57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:AURKB ^@ http://purl.uniprot.org/uniprot/A0A5F8HD14|||http://purl.uniprot.org/uniprot/F7ETI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centromere http://togogenome.org/gene/13616:SHROOM2 ^@ http://purl.uniprot.org/uniprot/F6YLT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/13616:BMT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GI30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the BMT2 family.|||Interacts with the GATOR1 complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine. Interacts with the KICSTOR complex; interaction is disrupted when BMT2/SAMTOR binds S-adenosyl-L-methionine.|||S-adenosyl-L-methionine-binding protein that acts as an inhibitor of mTORC1 signaling via interaction with the GATOR1 and KICSTOR complexes. Acts as a sensor of S-adenosyl-L-methionine to signal methionine sufficiency to mTORC1: in presence of methionine, binds S-adenosyl-L-methionine, leading to disrupt interaction with the GATOR1 and KICSTOR complexes and promote mTORC1 signaling. Upon methionine starvation, S-adenosyl-L-methionine levels are reduced, thereby promoting the association with GATOR1 and KICSTOR, leading to inhibit mTORC1 signaling. Probably also acts as a S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/13616:monDomV1R1265 ^@ http://purl.uniprot.org/uniprot/F6V7H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NMNAT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHY9 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/13616:EGF ^@ http://purl.uniprot.org/uniprot/F6R392 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ALX1 ^@ http://purl.uniprot.org/uniprot/F7F534 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1258 ^@ http://purl.uniprot.org/uniprot/F6Z3N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SKA2 ^@ http://purl.uniprot.org/uniprot/F6ZDE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/13616:LOC100031103 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCU4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC103097545 ^@ http://purl.uniprot.org/uniprot/F7F1Z4 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/13616:LOC100017233 ^@ http://purl.uniprot.org/uniprot/F7BTC7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||gap junction http://togogenome.org/gene/13616:LLGL1 ^@ http://purl.uniprot.org/uniprot/F6Z9W6 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/13616:LOC100030110 ^@ http://purl.uniprot.org/uniprot/K7E501 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/F6ZJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 90 family.|||Melanosome http://togogenome.org/gene/13616:ATP8A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX28|||http://purl.uniprot.org/uniprot/F6PFT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:PNPLA4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H039|||http://purl.uniprot.org/uniprot/A0A5F8H674|||http://purl.uniprot.org/uniprot/F7F1B0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SLCO5A1 ^@ http://purl.uniprot.org/uniprot/F7GKH7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ADRA2C ^@ http://purl.uniprot.org/uniprot/F7EG22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-2 adrenergic receptors mediate the catecholamine-induced inhibition of adenylate cyclase through the action of G proteins.|||Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1N1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.|||Membrane http://togogenome.org/gene/13616:LOC100023204 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK09|||http://purl.uniprot.org/uniprot/F7D0J8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:LOC103103199 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUZ5 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/13616:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/F7B2V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:TMEFF2 ^@ http://purl.uniprot.org/uniprot/F7EGL9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:EIF3M ^@ http://purl.uniprot.org/uniprot/F6YBW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm http://togogenome.org/gene/13616:PRKACA ^@ http://purl.uniprot.org/uniprot/F7G4Q0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/13616:DUOXA1 ^@ http://purl.uniprot.org/uniprot/F7GG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/13616:CDC20B ^@ http://purl.uniprot.org/uniprot/F6RB64 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/13616:LOC100016216 ^@ http://purl.uniprot.org/uniprot/F6VIJ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/13616:F2R ^@ http://purl.uniprot.org/uniprot/F7BHX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADCY8 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL47|||http://purl.uniprot.org/uniprot/F7BCI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/13616:C2H1orf123 ^@ http://purl.uniprot.org/uniprot/F6URI1 ^@ Similarity ^@ Belongs to the UPF0587 family. http://togogenome.org/gene/13616:CARTPT ^@ http://purl.uniprot.org/uniprot/F6T7Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CART family.|||Secreted http://togogenome.org/gene/13616:BDKRB1 ^@ http://purl.uniprot.org/uniprot/F6T0H1 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||This is a receptor for bradykinin. Could be a factor in chronic pain and inflammation. http://togogenome.org/gene/13616:SIM1 ^@ http://purl.uniprot.org/uniprot/F7FT81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TRPC6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLA7|||http://purl.uniprot.org/uniprot/F6XN03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LAMTOR2 ^@ http://purl.uniprot.org/uniprot/F6V5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAMAD family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane http://togogenome.org/gene/13616:IRAK4 ^@ http://purl.uniprot.org/uniprot/F7GD74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/13616:CCNYL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSK8|||http://purl.uniprot.org/uniprot/F7FRS8 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin Y subfamily. http://togogenome.org/gene/13616:NSUN7 ^@ http://purl.uniprot.org/uniprot/F7AYL7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PPP1R16B ^@ http://purl.uniprot.org/uniprot/F7BMC3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CDC42SE1 ^@ http://purl.uniprot.org/uniprot/F7GKB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Interacts with CDC42 (in GTP-bound form). Interacts weakly with RAC1 and not at all with RHOA.|||Membrane|||Probably involved in the organization of the actin cytoskeleton by acting downstream of CDC42, inducing actin filament assembly. Alters CDC42-induced cell shape changes. In activated T-cells, may play a role in CDC42-mediated F-actin accumulation at the immunological synapse. May play a role in early contractile events in phagocytosis in macrophages.|||cytoskeleton http://togogenome.org/gene/13616:TBR1 ^@ http://purl.uniprot.org/uniprot/F6YLI5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9W3|||http://purl.uniprot.org/uniprot/A0A5F8GMV6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/13616:GDAP2 ^@ http://purl.uniprot.org/uniprot/F7A1V0 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/13616:TEKT2 ^@ http://purl.uniprot.org/uniprot/F7GFM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/13616:EDEM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7R1|||http://purl.uniprot.org/uniprot/F7ADR9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:CLRN3 ^@ http://purl.uniprot.org/uniprot/F6PT54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/13616:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A5F8GXJ5|||http://purl.uniprot.org/uniprot/F7C5P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/13616:LOC100013658 ^@ http://purl.uniprot.org/uniprot/F7C2G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031271 ^@ http://purl.uniprot.org/uniprot/F6RTB1 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/13616:OSBPL2 ^@ http://purl.uniprot.org/uniprot/F7D1T6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:SMAD2 ^@ http://purl.uniprot.org/uniprot/F6S0Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DPP4 ^@ http://purl.uniprot.org/uniprot/F7D0P2|||http://purl.uniprot.org/uniprot/K7DYU6 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/13616:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR96|||http://purl.uniprot.org/uniprot/A0A5F8H2X0 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/13616:LOC100024932 ^@ http://purl.uniprot.org/uniprot/F6PUC5 ^@ Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/13616:DLL4 ^@ http://purl.uniprot.org/uniprot/F6TFF9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/13616:LOC100029967 ^@ http://purl.uniprot.org/uniprot/F6W190 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:LOC100032742 ^@ http://purl.uniprot.org/uniprot/F6WPG6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/13616:C1H14orf166 ^@ http://purl.uniprot.org/uniprot/F7EW01 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/13616:SCN3B ^@ http://purl.uniprot.org/uniprot/F7G1T5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/13616:SYNJ2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIJ1|||http://purl.uniprot.org/uniprot/A0A5F8H903|||http://purl.uniprot.org/uniprot/F7AW70 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/13616:IPO9 ^@ http://purl.uniprot.org/uniprot/F6UA59 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:MASTL ^@ http://purl.uniprot.org/uniprot/A0A5F8GBQ1|||http://purl.uniprot.org/uniprot/F7B7P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Nucleus|||centrosome http://togogenome.org/gene/13616:VN2R641 ^@ http://purl.uniprot.org/uniprot/F7C1B7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ITM2B ^@ http://purl.uniprot.org/uniprot/F6ZAG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/13616:MCM7 ^@ http://purl.uniprot.org/uniprot/F6UBM6|||http://purl.uniprot.org/uniprot/K7E231 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:CAB39 ^@ http://purl.uniprot.org/uniprot/F7D4X6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/13616:LOC100017285 ^@ http://purl.uniprot.org/uniprot/F6W7W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFP11/STIP family.|||Identified in the spliceosome C complex. Found in the Intron Large (IL) complex, a post-mRNA release spliceosomal complex containing the excised intron, U2, U5 and U6 snRNPs, and splicing factors. Interacts with TUFT1. Interacts with DHX15; indicative for a recruitment of DHX15 to the IL complex. Interacts with GCFC2.|||Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP-containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extracellular matrix.|||Nucleus http://togogenome.org/gene/13616:FAM20C ^@ http://purl.uniprot.org/uniprot/F7FTS0 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/13616:PHYHIPL ^@ http://purl.uniprot.org/uniprot/F7EAV9 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/13616:CKS1B ^@ http://purl.uniprot.org/uniprot/F6U382 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/13616:MRPL51 ^@ http://purl.uniprot.org/uniprot/F7G4E8 ^@ Similarity ^@ Belongs to the mitochondrion-specific ribosomal protein mL51 family. http://togogenome.org/gene/13616:RPN1 ^@ http://purl.uniprot.org/uniprot/F6YJ80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/13616:MED11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJ15|||http://purl.uniprot.org/uniprot/F7BWH5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:ETV5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHC5|||http://purl.uniprot.org/uniprot/F7AAC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:CD68 ^@ http://purl.uniprot.org/uniprot/F6SI34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/13616:MS4A13 ^@ http://purl.uniprot.org/uniprot/F7G7B2 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:KEG11_p02 ^@ http://purl.uniprot.org/uniprot/Q65CI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/13616:KCNK15 ^@ http://purl.uniprot.org/uniprot/F7FY32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:LOC100029911 ^@ http://purl.uniprot.org/uniprot/F6Z8E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:XKR5 ^@ http://purl.uniprot.org/uniprot/F7FM86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/13616:FAM63A ^@ http://purl.uniprot.org/uniprot/F7GKG5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/13616:RNF141 ^@ http://purl.uniprot.org/uniprot/F7DJU9 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/13616:TMTC3 ^@ http://purl.uniprot.org/uniprot/F7EP59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/13616:IL1RL1 ^@ http://purl.uniprot.org/uniprot/F7GDA3 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/13616:ACER2 ^@ http://purl.uniprot.org/uniprot/F6VW29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/13616:MS4A1 ^@ http://purl.uniprot.org/uniprot/F7G7B8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/13616:SBK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Cytoplasm http://togogenome.org/gene/13616:PCSK6 ^@ http://purl.uniprot.org/uniprot/F7B8Z0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/13616:TUSC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ85|||http://purl.uniprot.org/uniprot/A0A5F8GM09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CHRNA6 ^@ http://purl.uniprot.org/uniprot/F6WNN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:MFSD1 ^@ http://purl.uniprot.org/uniprot/F6RJN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:THBS2 ^@ http://purl.uniprot.org/uniprot/F6XY15 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100012785 ^@ http://purl.uniprot.org/uniprot/F7DKQ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100028177 ^@ http://purl.uniprot.org/uniprot/F7E8Y4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:NODAL ^@ http://purl.uniprot.org/uniprot/F7CYQ7 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:PIK3C2B ^@ http://purl.uniprot.org/uniprot/F7BBM1 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/13616:GMPR2 ^@ http://purl.uniprot.org/uniprot/F6THE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family. GuaC type 1 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides.|||Homotetramer. http://togogenome.org/gene/13616:RPL32 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAP3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/13616:C1H16orf87 ^@ http://purl.uniprot.org/uniprot/F7DY20 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/13616:LOC100020912 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1U1 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:TMEM2 ^@ http://purl.uniprot.org/uniprot/F7CEF4 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/13616:TMEM255A ^@ http://purl.uniprot.org/uniprot/F6VLX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/13616:LOC100030425 ^@ http://purl.uniprot.org/uniprot/F7B4E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103102474 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF55 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/13616:MRPL12 ^@ http://purl.uniprot.org/uniprot/F6PNJ3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/13616:PAQR5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD34|||http://purl.uniprot.org/uniprot/A0A5F8H5Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:GPR18 ^@ http://purl.uniprot.org/uniprot/F7EB53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/13616:FOXS1 ^@ http://purl.uniprot.org/uniprot/F6WAA9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SNX6 ^@ http://purl.uniprot.org/uniprot/F7ERS0 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/13616:FUT8 ^@ http://purl.uniprot.org/uniprot/F6XAH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 23 family.|||Catalyzes the addition of fucose in alpha 1-6 linkage to the first GlcNAc residue, next to the peptide chains in N-glycans.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/13616:LOC100033297 ^@ http://purl.uniprot.org/uniprot/F7FAG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:SRSF2 ^@ http://purl.uniprot.org/uniprot/F7BX00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Nucleus http://togogenome.org/gene/13616:MKRN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSH8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100012131 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGR0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:EEF1A1 ^@ http://purl.uniprot.org/uniprot/F6YDH0 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/13616:BBS4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIT6|||http://purl.uniprot.org/uniprot/F6QM11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||centrosome|||cilium membrane http://togogenome.org/gene/13616:LAMB2 ^@ http://purl.uniprot.org/uniprot/F6ZKA9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/13616:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ84|||http://purl.uniprot.org/uniprot/A0A5F8H119|||http://purl.uniprot.org/uniprot/A0A5F8H3Q2|||http://purl.uniprot.org/uniprot/F7FC55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ZADH2 ^@ http://purl.uniprot.org/uniprot/F7EIM5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/13616:GAB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJS8 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/13616:HAGHL ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ45|||http://purl.uniprot.org/uniprot/F7G5Y2 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/13616:PNPLA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKC3|||http://purl.uniprot.org/uniprot/F7AVV1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100019538 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/13616:KATNAL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4S8|||http://purl.uniprot.org/uniprot/F6ZPW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/13616:ACVR2B ^@ http://purl.uniprot.org/uniprot/A0A5F8GCP7|||http://purl.uniprot.org/uniprot/F7BRY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/13616:UNC93A ^@ http://purl.uniprot.org/uniprot/F7F0N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/13616:KCNK9 ^@ http://purl.uniprot.org/uniprot/F6SSW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/13616:TMEM150A ^@ http://purl.uniprot.org/uniprot/F6YFN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRAM/TMEM150 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1263 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MAP3K7 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5G8|||http://purl.uniprot.org/uniprot/A0A5F8GJ40 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by pro-inflammatory cytokines and in response to physical and chemical stresses, including osmotic stress, oxidative stress, arsenic and ultraviolet light irradiation. Activated by 'Lys-63'-linked polyubiquitination and by autophosphorylation.|||Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Cytoplasm http://togogenome.org/gene/13616:PABPC4 ^@ http://purl.uniprot.org/uniprot/F6YJX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/13616:LOC100025087 ^@ http://purl.uniprot.org/uniprot/F6SVK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:PCYT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8T9|||http://purl.uniprot.org/uniprot/F6PLX5 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/13616:ZNF622 ^@ http://purl.uniprot.org/uniprot/F7DCD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/13616:FAM96B ^@ http://purl.uniprot.org/uniprot/F7CX16 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/13616:LOC100032302 ^@ http://purl.uniprot.org/uniprot/F6VUC1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/13616:LOC100014635 ^@ http://purl.uniprot.org/uniprot/F6Y610 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MPG ^@ http://purl.uniprot.org/uniprot/F6YNB3 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/13616:HOXB7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:SLC35A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/13616:SEMA4C ^@ http://purl.uniprot.org/uniprot/F6UE98 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RHOT1 ^@ http://purl.uniprot.org/uniprot/F7FMB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:LOC100030127 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKM4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pentraxin family.|||Binds 2 calcium ions per subunit.|||Homopentamer. Pentaxin (or pentraxin) have a discoid arrangement of 5 non-covalently bound subunits.|||Secreted http://togogenome.org/gene/13616:ERBB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/13616:FAM213A ^@ http://purl.uniprot.org/uniprot/A0A5F8GWH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxiredoxin-like PRXL2 family. PRXL2A subfamily.|||Cytoplasm http://togogenome.org/gene/13616:ADGRA3 ^@ http://purl.uniprot.org/uniprot/F6WP14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/13616:CA14 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDW3|||http://purl.uniprot.org/uniprot/F7ADM5 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/13616:GTF2E1 ^@ http://purl.uniprot.org/uniprot/F6PGB5 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/13616:UPP2 ^@ http://purl.uniprot.org/uniprot/F6RS33 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/13616:RUNX1T1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF88|||http://purl.uniprot.org/uniprot/A0A5F8GNU7 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/13616:GNMT ^@ http://purl.uniprot.org/uniprot/F7C5H5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Glycine N-methyltransferase family. http://togogenome.org/gene/13616:EDEM1 ^@ http://purl.uniprot.org/uniprot/F6R5E1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:CD79B ^@ http://purl.uniprot.org/uniprot/D7F469 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PARG ^@ http://purl.uniprot.org/uniprot/F7DIG7 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/13616:YME1L1 ^@ http://purl.uniprot.org/uniprot/F7BVC8 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/13616:ABCG5 ^@ http://purl.uniprot.org/uniprot/F6X4Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/13616:LOC103103968 ^@ http://purl.uniprot.org/uniprot/A0A5F8H357 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ARSG ^@ http://purl.uniprot.org/uniprot/A0A5F8GNI3|||http://purl.uniprot.org/uniprot/F6SVG1 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:UBQLN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4P0|||http://purl.uniprot.org/uniprot/F7CXM6 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus|||autophagosome http://togogenome.org/gene/13616:NDUFB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100024824 ^@ http://purl.uniprot.org/uniprot/F7GII8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SMC1B ^@ http://purl.uniprot.org/uniprot/F6VWT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:LOC100025782 ^@ http://purl.uniprot.org/uniprot/F7CKQ0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:ACHE ^@ http://purl.uniprot.org/uniprot/F7C2P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/13616:KEG11_p10 ^@ http://purl.uniprot.org/uniprot/Q65CJ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:CLRN2 ^@ http://purl.uniprot.org/uniprot/F7AVP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/13616:RNFT1 ^@ http://purl.uniprot.org/uniprot/F6W4Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:KCTD3 ^@ http://purl.uniprot.org/uniprot/F6ZPV3 ^@ Similarity ^@ Belongs to the KCTD3 family. http://togogenome.org/gene/13616:FFAR2 ^@ http://purl.uniprot.org/uniprot/F6W8H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMEM17 ^@ http://purl.uniprot.org/uniprot/F6PQE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PURA ^@ http://purl.uniprot.org/uniprot/F7FSY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PUR DNA-binding protein family.|||Nucleus http://togogenome.org/gene/13616:TMEM161A ^@ http://purl.uniprot.org/uniprot/F6VW04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/13616:ITGB3 ^@ http://purl.uniprot.org/uniprot/F7FW35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/13616:LOC100011313 ^@ http://purl.uniprot.org/uniprot/F7DIB7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:FAM124B ^@ http://purl.uniprot.org/uniprot/F6UH70 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/13616:PFKFB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G879|||http://purl.uniprot.org/uniprot/F6U5M3 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/13616:SCUBE2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH90 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:GMNN ^@ http://purl.uniprot.org/uniprot/F7GE78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1278 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HAO2 ^@ http://purl.uniprot.org/uniprot/F7GGG1 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/13616:CHST14 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LYAR ^@ http://purl.uniprot.org/uniprot/F7F4L6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:PSEN2 ^@ http://purl.uniprot.org/uniprot/F7EIE5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/13616:CCL20 ^@ http://purl.uniprot.org/uniprot/K7E0V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:LOC100031866 ^@ http://purl.uniprot.org/uniprot/F6Y6H3 ^@ Function|||Similarity ^@ Belongs to the UFM1 family.|||Ubiquitin-like modifier which can be covalently attached via an isopeptide bond to lysine residues of substrate proteins as a monomer or a lysine-linked polymer. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/13616:LOC100021412 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CNDP2 ^@ http://purl.uniprot.org/uniprot/F7DHK3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/13616:SNX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGR3|||http://purl.uniprot.org/uniprot/F6WI51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Early endosome membrane|||Endosome membrane|||Membrane|||lamellipodium http://togogenome.org/gene/13616:SLC25A27 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100013197 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:SLC15A4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/13616:MAP3K9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G873|||http://purl.uniprot.org/uniprot/F6RYB4 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/13616:MARK3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G689|||http://purl.uniprot.org/uniprot/A0A5F8GGQ5|||http://purl.uniprot.org/uniprot/A0A5F8HIE6|||http://purl.uniprot.org/uniprot/A0A5F8HJ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/13616:RPS3A ^@ http://purl.uniprot.org/uniprot/F7ESW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. Binds with high affinity to IPO4. Interacts with DDIT3.|||Cytoplasm|||May play a role during erythropoiesis through regulation of transcription factor DDIT3.|||Nucleus http://togogenome.org/gene/13616:SPICE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7S9 ^@ Subcellular Location Annotation|||Subunit ^@ Interacts with CEP120.|||centriole|||spindle http://togogenome.org/gene/13616:USP1 ^@ http://purl.uniprot.org/uniprot/F7F488 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:SLC25A11 ^@ http://purl.uniprot.org/uniprot/F6YLG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:GATA4 ^@ http://purl.uniprot.org/uniprot/F7B924 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SUGP1 ^@ http://purl.uniprot.org/uniprot/F6UEG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SLC35D2 ^@ http://purl.uniprot.org/uniprot/F6U9P9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LPCAT1 ^@ http://purl.uniprot.org/uniprot/F7BCV0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC55|||http://purl.uniprot.org/uniprot/F7FQ00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:BOP1 ^@ http://purl.uniprot.org/uniprot/F7GHR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A5F8HFE2|||http://purl.uniprot.org/uniprot/F7A2Q4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/13616:TRIM36 ^@ http://purl.uniprot.org/uniprot/F7DGH4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:NT5C2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVB7|||http://purl.uniprot.org/uniprot/F7ANM0 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/13616:LOC100019961 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQP4 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/13616:INTS3 ^@ http://purl.uniprot.org/uniprot/F6VZW0 ^@ Similarity ^@ Belongs to the Integrator subunit 3 family. http://togogenome.org/gene/13616:GOLPH3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/13616:IRF2BP1 ^@ http://purl.uniprot.org/uniprot/F7E0A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF2BP family.|||Nucleus http://togogenome.org/gene/13616:SMARCA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLS8|||http://purl.uniprot.org/uniprot/F7FQB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/13616:LOC100020228 ^@ http://purl.uniprot.org/uniprot/F7F450 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/13616:TSPAN9 ^@ http://purl.uniprot.org/uniprot/F6PRY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:LOC100022942 ^@ http://purl.uniprot.org/uniprot/F7DG91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:IL2RB ^@ http://purl.uniprot.org/uniprot/F6SBB8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/13616:AKT1 ^@ http://purl.uniprot.org/uniprot/F6QP11 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/13616:SDC3 ^@ http://purl.uniprot.org/uniprot/F6XHV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/13616:FAM189B ^@ http://purl.uniprot.org/uniprot/F7E0N9 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/13616:PIWIL4 ^@ http://purl.uniprot.org/uniprot/F6SZK3 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/13616:FGF16 ^@ http://purl.uniprot.org/uniprot/F7D846 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:monDomV1R1244 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC35A5 ^@ http://purl.uniprot.org/uniprot/F7F201 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/13616:PELI2 ^@ http://purl.uniprot.org/uniprot/F7FZH7 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/13616:GLG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2J2|||http://purl.uniprot.org/uniprot/F6YPR6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Golgi outpost|||Membrane|||microtubule organizing center http://togogenome.org/gene/13616:PIK3CG ^@ http://purl.uniprot.org/uniprot/F7E9G2 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/13616:TMPRSS5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6F6|||http://purl.uniprot.org/uniprot/A0A5F8H3S0|||http://purl.uniprot.org/uniprot/F6TRE7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100029976 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5P3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:LOC100028625 ^@ http://purl.uniprot.org/uniprot/F7G428 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/13616:CCS ^@ http://purl.uniprot.org/uniprot/F6YJP8 ^@ Similarity ^@ In the C-terminal section; belongs to the Cu-Zn superoxide dismutase family. http://togogenome.org/gene/13616:CDK5R1 ^@ http://purl.uniprot.org/uniprot/F7F8X9 ^@ Similarity|||Subunit ^@ Belongs to the cyclin-dependent kinase 5 activator family.|||Heterodimer of a catalytic subunit and a regulatory subunit. http://togogenome.org/gene/13616:MOCOS ^@ http://purl.uniprot.org/uniprot/A0A5F8GKW1|||http://purl.uniprot.org/uniprot/A0A5F8GXY5 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/13616:KPNA4 ^@ http://purl.uniprot.org/uniprot/F7FL50 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:EMC7 ^@ http://purl.uniprot.org/uniprot/F6T7N4 ^@ Similarity|||Subunit ^@ Belongs to the EMC7 family.|||Component of the ER membrane protein complex (EMC). http://togogenome.org/gene/13616:CCK ^@ http://purl.uniprot.org/uniprot/F7EMB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/13616:LOC100619918 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NUDT21 ^@ http://purl.uniprot.org/uniprot/F7DTJ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/13616:PCSK2 ^@ http://purl.uniprot.org/uniprot/F7G632 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/13616:MCM10 ^@ http://purl.uniprot.org/uniprot/F6QH58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/13616:HOXD13 ^@ http://purl.uniprot.org/uniprot/F7BJZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:HDAC9 ^@ http://purl.uniprot.org/uniprot/F7BC62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/13616:SNRPB ^@ http://purl.uniprot.org/uniprot/Q9TU66 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP SmB/SmN family.|||Core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Most spliceosomal snRNPs contain a common set of Sm proteins, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP (By similarity). Component of the U1 snRNP (By similarity). The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG, and at least three U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C (By similarity). Component of the U4/U6-U5 tri-snRNP complex composed of the U4, U6 and U5 snRNAs and at least PRPF3, PRPF4, PRPF6, PRPF8, PRPF31, SNRNP200, TXNL4A, SNRNP40, SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF, SNRPG, DDX23, CD2BP2, PPIH, SNU13, EFTUD2, SART1 and USP39, plus LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8 (By similarity). Component of the U7 snRNP complex, or U7 Sm protein core complex, that is composed of the U7 snRNA and at least LSM10, LSM11, SNRPB, SNRPD3, SNRPE, SNRPF and SNRPG; the complex does not contain SNRPD1 and SNRPD2 (By similarity). Component of the U11/U12 snRNPs that are part of the U12-type spliceosome (By similarity). Part of the SMN-Sm complex that contains SMN1, GEMIN2/SIP1, DDX20/GEMIN3, GEMIN4, GEMIN5, GEMIN6, GEMIN7, GEMIN8, STRAP/UNRIP and the Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG; catalyzes core snRNPs assembly (By similarity). Forms a 6S pICln-Sm complex composed of CLNS1A/pICln, SNRPD1, SNRPD2, SNRPE, SNRPF and SNRPG; ring-like structure where CLNS1A/pICln mimics additional Sm proteins and which is unable to assemble into the core snRNP (By similarity). Identified in a histone pre-mRNA complex, at least composed of ERI1, LSM11, SLBP, SNRPB, SYNCRIP and YBX1 (By similarity). Interacts with TDRD3 and SNUPN (By similarity). Interacts with PRMT5; interaction leads to its symmetric arginine dimethylation (By similarity). Interacts with TDRD6; interaction promotes association with PRMT5 (By similarity). Interacts with SMN1; the interaction is direct (By similarity).|||Methylated by PRMT5 (By similarity). Arg-108 and Arg-112 are dimethylated, probably to asymmetric dimethylarginine (By similarity).|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome (By similarity). Component of both the pre-catalytic spliceosome B complex and activated spliceosome C complexes (By similarity). Is also a component of the minor U12 spliceosome (By similarity). As part of the U7 snRNP it is involved in histone pre-mRNA 3'-end processing (By similarity).|||cytosol http://togogenome.org/gene/13616:PALM ^@ http://purl.uniprot.org/uniprot/F6ZR04 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/13616:TIMM17A ^@ http://purl.uniprot.org/uniprot/F6Y5K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex at least composed of TIMM23, TIMM17 (TIMM17A or TIMM17B) and TIMM50.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ADAM22 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL95|||http://purl.uniprot.org/uniprot/F6S926 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ZFP36 ^@ http://purl.uniprot.org/uniprot/A0A5F8H080 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/13616:LOC100029137 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6P6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:MCTS1 ^@ http://purl.uniprot.org/uniprot/F6RPB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCTS1 family.|||Cytoplasm http://togogenome.org/gene/13616:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/F7CAA2 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/13616:LTBP2 ^@ http://purl.uniprot.org/uniprot/F7FRW6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:LOC100024691 ^@ http://purl.uniprot.org/uniprot/F7D533 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/13616:LOC100024395 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:XK ^@ http://purl.uniprot.org/uniprot/F6U2W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/13616:LOC100012829 ^@ http://purl.uniprot.org/uniprot/F6QLL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100027914 ^@ http://purl.uniprot.org/uniprot/F6SWK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G635|||http://purl.uniprot.org/uniprot/A0A5F8GXI1|||http://purl.uniprot.org/uniprot/F7CN44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/13616:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/F6XMM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/13616:FYN ^@ http://purl.uniprot.org/uniprot/F7FG65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:CTU1 ^@ http://purl.uniprot.org/uniprot/F6RN02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3. May form a heterodimer with CTU2/NCS2.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/13616:URAD ^@ http://purl.uniprot.org/uniprot/A0A5F8G3T1 ^@ Function|||Similarity ^@ Belongs to the OHCU decarboxylase family.|||Catalyzes the stereoselective decarboxylation of 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU) to (S)-allantoin. http://togogenome.org/gene/13616:SLC46A3 ^@ http://purl.uniprot.org/uniprot/F7B0M8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GTF2H4 ^@ http://purl.uniprot.org/uniprot/F7F0D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/13616:CXHXorf56 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCG9|||http://purl.uniprot.org/uniprot/F6ST98 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/13616:LOC100021052 ^@ http://purl.uniprot.org/uniprot/F6RPF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TLR2 ^@ http://purl.uniprot.org/uniprot/F6UTM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Cooperates with LY96 to mediate the innate immune response to bacterial lipoproteins and other microbial cell wall components. Cooperates with TLR1 or TLR6 to mediate the innate immune response to bacterial lipoproteins or lipopeptides. Acts via MYD88 and TRAF6, leading to NF-kappa-B activation, cytokine secretion and the inflammatory response.|||Membrane|||Membrane raft|||phagosome membrane http://togogenome.org/gene/13616:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP12|||http://purl.uniprot.org/uniprot/A0A5F8GP94|||http://purl.uniprot.org/uniprot/F7DCK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/13616:OSTC ^@ http://purl.uniprot.org/uniprot/A0A5F8H7T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. May be involved in N-glycosylation of APP (amyloid-beta precursor protein). Can modulate gamma-secretase cleavage of APP by enhancing endoprotelysis of PSEN1. http://togogenome.org/gene/13616:PHF10 ^@ http://purl.uniprot.org/uniprot/A0A5F8H364|||http://purl.uniprot.org/uniprot/F6UKY4|||http://purl.uniprot.org/uniprot/K7E191 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAYP family.|||Nucleus http://togogenome.org/gene/13616:LOC100020659 ^@ http://purl.uniprot.org/uniprot/K7E0E2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:KDM4C ^@ http://purl.uniprot.org/uniprot/F6V4I6 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/13616:APOM ^@ http://purl.uniprot.org/uniprot/A0A5F8HA42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/13616:NSUN2 ^@ http://purl.uniprot.org/uniprot/F6QCU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||extracellular exosome http://togogenome.org/gene/13616:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G687|||http://purl.uniprot.org/uniprot/A0A5F8GAT2|||http://purl.uniprot.org/uniprot/F6RD25 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/13616:NT5DC3 ^@ http://purl.uniprot.org/uniprot/F7CVK9 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/13616:PLA1A ^@ http://purl.uniprot.org/uniprot/F7B6S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:SPCS3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:CCR6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLZ2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:TBCE ^@ http://purl.uniprot.org/uniprot/A0A5F8GJR5|||http://purl.uniprot.org/uniprot/F7FGW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/13616:FAM155B ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Z4|||http://purl.uniprot.org/uniprot/F6UND5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NALF family.|||Membrane http://togogenome.org/gene/13616:SDF4 ^@ http://purl.uniprot.org/uniprot/F7A470 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/13616:CRABP2 ^@ http://purl.uniprot.org/uniprot/F7FVK2 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:POMGNT1 ^@ http://purl.uniprot.org/uniprot/F6UGR6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/13616:VN2R643 ^@ http://purl.uniprot.org/uniprot/F7BFV4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:YAF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5V8|||http://purl.uniprot.org/uniprot/A0A5F8HJ01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CHST13 ^@ http://purl.uniprot.org/uniprot/F7BKN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:HPGD ^@ http://purl.uniprot.org/uniprot/A0A5F8G5J7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:EIF2B2 ^@ http://purl.uniprot.org/uniprot/F7FF88 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/13616:GRIN2C ^@ http://purl.uniprot.org/uniprot/F6PSD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Membrane http://togogenome.org/gene/13616:PSMA8 ^@ http://purl.uniprot.org/uniprot/F7FSH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:RTN4IP1 ^@ http://purl.uniprot.org/uniprot/F6Y476|||http://purl.uniprot.org/uniprot/K7E2Y8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/13616:EMG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAG1 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/13616:KCNAB3 ^@ http://purl.uniprot.org/uniprot/F7G0A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/13616:DBX1 ^@ http://purl.uniprot.org/uniprot/F7FQV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:OGT ^@ http://purl.uniprot.org/uniprot/F6Y3C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/13616:IAPP ^@ http://purl.uniprot.org/uniprot/A0A5F8H6U1 ^@ Function|||Similarity ^@ Belongs to the calcitonin family.|||Selectively inhibits insulin-stimulated glucose utilization and glycogen deposition in muscle, while not affecting adipocyte glucose metabolism. http://togogenome.org/gene/13616:COPS8 ^@ http://purl.uniprot.org/uniprot/F7CRI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN8 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC103098551 ^@ http://purl.uniprot.org/uniprot/F7E6F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TAS1R1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIS7|||http://purl.uniprot.org/uniprot/F6SLE6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:PLBD1 ^@ http://purl.uniprot.org/uniprot/F7B6W0 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/13616:CPSF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6G5|||http://purl.uniprot.org/uniprot/A0A5F8H051|||http://purl.uniprot.org/uniprot/F6SH96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Cytoplasm|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/13616:DOK5 ^@ http://purl.uniprot.org/uniprot/F7E8P9 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/13616:EPHA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3K2|||http://purl.uniprot.org/uniprot/F7APP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ANKLE2 ^@ http://purl.uniprot.org/uniprot/F7BA30 ^@ Similarity ^@ Belongs to the ANKLE2 family. http://togogenome.org/gene/13616:STC1 ^@ http://purl.uniprot.org/uniprot/F7G6I0 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/13616:KCNJ10 ^@ http://purl.uniprot.org/uniprot/F6PGD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/13616:FAM219B ^@ http://purl.uniprot.org/uniprot/A0A5F8GX09 ^@ Similarity ^@ Belongs to the FAM219 family. http://togogenome.org/gene/13616:LOC100023635 ^@ http://purl.uniprot.org/uniprot/F7DDZ3 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/13616:LOC103098388 ^@ http://purl.uniprot.org/uniprot/K7E508 ^@ Subcellular Location Annotation ^@ Membrane raft|||phagosome membrane http://togogenome.org/gene/13616:SPRN ^@ http://purl.uniprot.org/uniprot/A2BDG4 ^@ Function|||Similarity ^@ Belongs to the SPRN family.|||Prion-like protein that has PrP(C)-like neuroprotective activity. May act as a modulator for the biological actions of normal and abnormal PrP. http://togogenome.org/gene/13616:GSX1 ^@ http://purl.uniprot.org/uniprot/F7BPX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:AZGP1 ^@ http://purl.uniprot.org/uniprot/F6PMH2 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:SEMA3B ^@ http://purl.uniprot.org/uniprot/F7CEG7 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ICT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4P4 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/13616:SLC11A1 ^@ http://purl.uniprot.org/uniprot/F6WFG3 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/13616:NFU1 ^@ http://purl.uniprot.org/uniprot/F7CBJ3 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/13616:MB21D2 ^@ http://purl.uniprot.org/uniprot/F7ELX9 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/13616:LOC100011174 ^@ http://purl.uniprot.org/uniprot/F6T501 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:CD28 ^@ http://purl.uniprot.org/uniprot/F7AY22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DFNA5 ^@ http://purl.uniprot.org/uniprot/F6W5Y9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:IRX1 ^@ http://purl.uniprot.org/uniprot/F7BBU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/13616:KCNJ11 ^@ http://purl.uniprot.org/uniprot/F6XUJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/13616:ADGRG5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FIGF ^@ http://purl.uniprot.org/uniprot/F6WHL4 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/13616:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/F6SKP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100031900 ^@ http://purl.uniprot.org/uniprot/F6XJ86 ^@ Similarity ^@ Belongs to the lst-2 family. http://togogenome.org/gene/13616:TMEM59L ^@ http://purl.uniprot.org/uniprot/F7GBI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A5F8G207|||http://purl.uniprot.org/uniprot/A0A5F8GBG4|||http://purl.uniprot.org/uniprot/A0A5F8GQJ4|||http://purl.uniprot.org/uniprot/F6QEH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:TBX20 ^@ http://purl.uniprot.org/uniprot/F6Q953 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:MED26 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCF8|||http://purl.uniprot.org/uniprot/A0A5F8HCS2|||http://purl.uniprot.org/uniprot/A0A5F8HIV1|||http://purl.uniprot.org/uniprot/F7FID8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 26 family.|||Nucleus http://togogenome.org/gene/13616:RPL23 ^@ http://purl.uniprot.org/uniprot/F6WU43 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Component of the large ribosomal subunit.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/13616:ENOPH1 ^@ http://purl.uniprot.org/uniprot/F7DZJ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/13616:LOC107649407 ^@ http://purl.uniprot.org/uniprot/F7DRG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CAND2 ^@ http://purl.uniprot.org/uniprot/F7G2I7 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/13616:PDC ^@ http://purl.uniprot.org/uniprot/F6YE86 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/13616:LOC100022788 ^@ http://purl.uniprot.org/uniprot/F7CMZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:AXIN2 ^@ http://purl.uniprot.org/uniprot/F6TVK6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:RNASE4 ^@ http://purl.uniprot.org/uniprot/F6QVB3 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/13616:SSTR2 ^@ http://purl.uniprot.org/uniprot/F7F878 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/13616:PLPPR3 ^@ http://purl.uniprot.org/uniprot/F7FE27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:SULT6B1 ^@ http://purl.uniprot.org/uniprot/F6TLW8 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:PHKG2 ^@ http://purl.uniprot.org/uniprot/F7ANI3 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/13616:PSME3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5U2 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/13616:GNG8 ^@ http://purl.uniprot.org/uniprot/F6YZA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:PSMB11 ^@ http://purl.uniprot.org/uniprot/F7CZ29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TCP11L1 ^@ http://purl.uniprot.org/uniprot/F6XSJ5 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/13616:UCHL1 ^@ http://purl.uniprot.org/uniprot/P50103 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C12 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||In contrast to UCHL3, does not hydrolyze a peptide bond at the C-terminal glycine of NEDD8.|||Monomer. Homodimer. Interacts with COPS5 and SNCA (By similarity).|||O-glycosylated.|||The homodimer may have ATP-independent ubiquitin ligase activity. However, in another study, UCHL1 was shown to lack ubiquitin ligase activity.|||Ubiquitin-protein hydrolase involved both in the processing of ubiquitin precursors and of ubiquitinated proteins. This enzyme is a thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of ubiquitin (By similarity). Also binds to free monoubiquitin and may prevent its degradation in lysosomes (By similarity). The homodimer may have ATP-independent ubiquitin ligase activity (By similarity). http://togogenome.org/gene/13616:CDH3 ^@ http://purl.uniprot.org/uniprot/F7EGB5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NOC3L ^@ http://purl.uniprot.org/uniprot/F6VL05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/13616:RAB27A ^@ http://purl.uniprot.org/uniprot/F7D6A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/13616:ZACN ^@ http://purl.uniprot.org/uniprot/F6ZYC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SELE ^@ http://purl.uniprot.org/uniprot/A0A5F8HET5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:SYT2 ^@ http://purl.uniprot.org/uniprot/F6WM83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:STAG3 ^@ http://purl.uniprot.org/uniprot/F6RTQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/13616:CILP ^@ http://purl.uniprot.org/uniprot/F6SSK8 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/13616:SEC16A ^@ http://purl.uniprot.org/uniprot/F7B5A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/13616:TNKS ^@ http://purl.uniprot.org/uniprot/A0A5F8GUB1 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:ALLC ^@ http://purl.uniprot.org/uniprot/A0A5F8H3S7|||http://purl.uniprot.org/uniprot/F7ERQ3 ^@ Function|||Similarity ^@ Belongs to the allantoicase family.|||The function of this enzyme is unclear as allantoicase activity is not known to exist in mammals. http://togogenome.org/gene/13616:THTPA ^@ http://purl.uniprot.org/uniprot/A0A5F8GA32 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ThTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Hydrolase highly specific for thiamine triphosphate (ThTP).|||Monomer. http://togogenome.org/gene/13616:DEDD ^@ http://purl.uniprot.org/uniprot/A0A5F8GXA3|||http://purl.uniprot.org/uniprot/A0A5F8GYM0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:LOC100026824 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDW6|||http://purl.uniprot.org/uniprot/F6QBU5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:GJD3 ^@ http://purl.uniprot.org/uniprot/F7BMQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:WNT9A ^@ http://purl.uniprot.org/uniprot/F6SF10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:KCNK5 ^@ http://purl.uniprot.org/uniprot/F6ZM60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:DHRS7 ^@ http://purl.uniprot.org/uniprot/F7CCB2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H532|||http://purl.uniprot.org/uniprot/A0A5F8HHK5|||http://purl.uniprot.org/uniprot/F7G243 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100031116 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGW3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:AFF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9R2|||http://purl.uniprot.org/uniprot/F7F3C1 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/13616:ARID5B ^@ http://purl.uniprot.org/uniprot/F6V2Y7 ^@ Similarity ^@ Belongs to the ARID5B family. http://togogenome.org/gene/13616:NATD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HII4|||http://purl.uniprot.org/uniprot/F7BD69 ^@ Similarity ^@ Belongs to the NATD1 family. http://togogenome.org/gene/13616:SPAG9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HE29 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/13616:TRAK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAG5|||http://purl.uniprot.org/uniprot/A0A5F8HIC1|||http://purl.uniprot.org/uniprot/A0A5F8HJA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/13616:MCCC2 ^@ http://purl.uniprot.org/uniprot/F6T882 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/13616:EDN2 ^@ http://purl.uniprot.org/uniprot/K7E5U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/13616:SGSH ^@ http://purl.uniprot.org/uniprot/F7DFZ7 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:MDM2 ^@ http://purl.uniprot.org/uniprot/F6WSI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:PRPF4 ^@ http://purl.uniprot.org/uniprot/F6RSY7 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/13616:STAG2 ^@ http://purl.uniprot.org/uniprot/F6ZBM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/13616:LOC100032863 ^@ http://purl.uniprot.org/uniprot/F6TG00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria. Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide.|||Secreted|||When bound to LPS, interacts (via C-terminus) with soluble and membrane-bound CD14. http://togogenome.org/gene/13616:RBM17 ^@ http://purl.uniprot.org/uniprot/F7GGT5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/13616:CYSLTR2 ^@ http://purl.uniprot.org/uniprot/F6XJU7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:GABRA2 ^@ http://purl.uniprot.org/uniprot/F6ZBY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/13616:CSRNP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8G9|||http://purl.uniprot.org/uniprot/A0A5F8GW02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/13616:LYRM4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXK9|||http://purl.uniprot.org/uniprot/A0A5F8H234|||http://purl.uniprot.org/uniprot/A0A5F8H7Y2 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/13616:LOC100026963 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8U1|||http://purl.uniprot.org/uniprot/A0A5F8GLF0|||http://purl.uniprot.org/uniprot/A0A5F8GTF8|||http://purl.uniprot.org/uniprot/A0A5F8HAI8|||http://purl.uniprot.org/uniprot/A0A5F8HJR8|||http://purl.uniprot.org/uniprot/K7E2P0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/13616:SETD3 ^@ http://purl.uniprot.org/uniprot/F7DB85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm|||Interacts with MYOD1. http://togogenome.org/gene/13616:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/F6ZT57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TES ^@ http://purl.uniprot.org/uniprot/Q2QLA1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prickle / espinas / testin family.|||Cytoplasm|||Interacts via LIM domain 1 with ZYX. Interacts (via LIM domain 3) with ENAH and VASP. Interacts with ALKBH4, talin, actin, alpha-actinin, GRIP1 and PXN (By similarity). Interacts (via LIM domain 2) with ACTL7A (via N-terminus). Heterodimer with ACTL7A; the heterodimer interacts with ENAH to form a heterotrimer (By similarity).|||Scaffold protein that may play a role in cell adhesion, cell spreading and in the reorganization of the actin cytoskeleton. Plays a role in the regulation of cell proliferation. May act as a tumor suppressor (By similarity).|||The N-terminal and the C-terminal halves of the protein can associate with each other, thereby hindering interactions with ZYX.|||focal adhesion http://togogenome.org/gene/13616:THSD1 ^@ http://purl.uniprot.org/uniprot/F7A7B0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plasmodium circumsporozoite protein family.|||Cell membrane|||Cytoplasm|||In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.|||Membrane http://togogenome.org/gene/13616:KHDRBS2 ^@ http://purl.uniprot.org/uniprot/F7FCC7 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/13616:FLOT1 ^@ http://purl.uniprot.org/uniprot/F7F085 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Cell membrane|||Endosome|||Heterooligomeric complex of flotillin-1 and flotillin-2 and caveolin-1 and caveolin-2. Interacts with ECPAS.|||Membrane|||caveola http://togogenome.org/gene/13616:GATA6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY33 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BMPR1B ^@ http://purl.uniprot.org/uniprot/F6Q8L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/13616:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB57|||http://purl.uniprot.org/uniprot/F6Z8A6|||http://purl.uniprot.org/uniprot/K7E5X4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/13616:LOC100617546 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PERP ^@ http://purl.uniprot.org/uniprot/F7AJF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/13616:CHST9 ^@ http://purl.uniprot.org/uniprot/F7FSF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100619446 ^@ http://purl.uniprot.org/uniprot/F7D289 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/13616:NRF1 ^@ http://purl.uniprot.org/uniprot/F6YNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRF1/Ewg family.|||Nucleus http://togogenome.org/gene/13616:TNFSF10 ^@ http://purl.uniprot.org/uniprot/A0A5F8H569 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tumor necrosis factor family.|||Homotrimer.|||Membrane|||Secreted http://togogenome.org/gene/13616:ERBB4 ^@ http://purl.uniprot.org/uniprot/F6ZSZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/13616:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/F6PW24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/13616:SLC40A1 ^@ http://purl.uniprot.org/uniprot/F6S5T6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/13616:HGFAC ^@ http://purl.uniprot.org/uniprot/F7CSQ9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:GJB2 ^@ http://purl.uniprot.org/uniprot/F6WYM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:DGKH ^@ http://purl.uniprot.org/uniprot/F6UU82 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/13616:WISP2 ^@ http://purl.uniprot.org/uniprot/F7FY31 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/13616:MCM5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H017 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/13616:NDOR1 ^@ http://purl.uniprot.org/uniprot/F6XFL1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/13616:DNTTIP1 ^@ http://purl.uniprot.org/uniprot/F6XI44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:WDPCP ^@ http://purl.uniprot.org/uniprot/F6PP46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/13616:LOC100018015 ^@ http://purl.uniprot.org/uniprot/F6QMG1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/13616:TAF11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX65 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/13616:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCA6|||http://purl.uniprot.org/uniprot/F6SFH6 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:CD109 ^@ http://purl.uniprot.org/uniprot/F7AG87 ^@ Similarity ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family. http://togogenome.org/gene/13616:LDHB ^@ http://purl.uniprot.org/uniprot/F7CZU2|||http://purl.uniprot.org/uniprot/Q9XT86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31; the interaction leads to inhibition of mitochondrial lactate dehydrogenase activity, preventing conversion of lactate to pyruvate in mitochondria.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+).|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100023056 ^@ http://purl.uniprot.org/uniprot/F7DGB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ENDOG ^@ http://purl.uniprot.org/uniprot/F7FGU3 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/13616:CNP ^@ http://purl.uniprot.org/uniprot/A0A5F8HDW2|||http://purl.uniprot.org/uniprot/F6ZC06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||May participate in RNA metabolism in the myelinating cell, CNP is the third most abundant protein in central nervous system myelin.|||Melanosome|||Membrane http://togogenome.org/gene/13616:DYNLL1 ^@ http://purl.uniprot.org/uniprot/F6WUZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/13616:CD5L ^@ http://purl.uniprot.org/uniprot/F7C178 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TRPM7 ^@ http://purl.uniprot.org/uniprot/F7GDX3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/13616:TUBGCP6 ^@ http://purl.uniprot.org/uniprot/F7FUQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||centrosome http://togogenome.org/gene/13616:TMEM170B ^@ http://purl.uniprot.org/uniprot/F6PPC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/13616:PROM2 ^@ http://purl.uniprot.org/uniprot/F7D5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/13616:LOC100022070 ^@ http://purl.uniprot.org/uniprot/F6W8S3 ^@ Similarity ^@ Belongs to the ficolin lectin family. http://togogenome.org/gene/13616:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7C2|||http://purl.uniprot.org/uniprot/F7FW54 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/13616:ATG7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWF5|||http://purl.uniprot.org/uniprot/F7BSZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 as well as the ATG8 family proteins for their conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Required for autophagic death induced by caspase-8 inhibition. Required for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Modulates p53/TP53 activity to regulate cell cycle and survival during metabolic stress.|||Homodimer.|||Preautophagosomal structure http://togogenome.org/gene/13616:SLC35F4 ^@ http://purl.uniprot.org/uniprot/F7AW98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/13616:UROD ^@ http://purl.uniprot.org/uniprot/F7BVV4 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:EVA1C ^@ http://purl.uniprot.org/uniprot/A0A5F8G984|||http://purl.uniprot.org/uniprot/A0A5F8GQC5|||http://purl.uniprot.org/uniprot/A0A5F8H651 ^@ Similarity ^@ Belongs to the EVA1 family. http://togogenome.org/gene/13616:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLL9|||http://purl.uniprot.org/uniprot/A0A5F8HKS6|||http://purl.uniprot.org/uniprot/F7DTF9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:KPNA7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUF5|||http://purl.uniprot.org/uniprot/F7GHM2 ^@ Function|||Similarity ^@ Belongs to the importin alpha family.|||Functions in nuclear protein import. http://togogenome.org/gene/13616:FAM98B ^@ http://purl.uniprot.org/uniprot/F7CK98 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/13616:ELOVL1 ^@ http://purl.uniprot.org/uniprot/F6WIJ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL1 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that exhibits activity toward saturated C18 to C26 acyl-CoA substrates, with the highest activity towards C22:0 acyl-CoA. May participate to the production of both saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. Important for saturated C24:0 and monounsaturated C24:1 sphingolipid synthesis. Indirectly inhibits RPE65 via production of VLCFAs.|||Endoplasmic reticulum membrane|||Interacts with LASS2, TECR and HSD17B12.|||Membrane|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/13616:LOC100020045 ^@ http://purl.uniprot.org/uniprot/F6PYR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:OPLAH ^@ http://purl.uniprot.org/uniprot/F6YTL4 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/13616:ABHD16A ^@ http://purl.uniprot.org/uniprot/F6TLV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. ABHD16 family.|||Membrane http://togogenome.org/gene/13616:TAMM41 ^@ http://purl.uniprot.org/uniprot/F7BSM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ATP1B1 ^@ http://purl.uniprot.org/uniprot/F6Q505 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the X(+)/potassium ATPases subunit beta family.|||Cell membrane|||Involved in cell adhesion and establishing epithelial cell polarity.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane.|||sarcolemma http://togogenome.org/gene/13616:TMEM87A ^@ http://purl.uniprot.org/uniprot/A0A5F8GGY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100022796 ^@ http://purl.uniprot.org/uniprot/F7A7F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SND1 ^@ http://purl.uniprot.org/uniprot/F7BW23 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Endonuclease that mediates miRNA decay of both protein-free and AGO2-loaded miRNAs. http://togogenome.org/gene/13616:KIF6 ^@ http://purl.uniprot.org/uniprot/F7B076 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:AK2 ^@ http://purl.uniprot.org/uniprot/F6VYY4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways. Plays a key role in hematopoiesis.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer. http://togogenome.org/gene/13616:BPGM ^@ http://purl.uniprot.org/uniprot/F6XLJ9 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/13616:MRPS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAM2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/13616:WRN ^@ http://purl.uniprot.org/uniprot/F7AMX7 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/13616:CKMT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9F7 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/13616:AIG1 ^@ http://purl.uniprot.org/uniprot/F6T3Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/13616:NKX2-4 ^@ http://purl.uniprot.org/uniprot/F7B5J5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:BRS3 ^@ http://purl.uniprot.org/uniprot/F6R4F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HLCS ^@ http://purl.uniprot.org/uniprot/A0A5F8H0K9|||http://purl.uniprot.org/uniprot/F6QZU6 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/13616:DPF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZE7 ^@ Similarity ^@ Belongs to the requiem/DPF family. http://togogenome.org/gene/13616:LSM3 ^@ http://purl.uniprot.org/uniprot/K7E291 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/13616:CEP170 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEQ9|||http://purl.uniprot.org/uniprot/A0A5F8GYE9|||http://purl.uniprot.org/uniprot/A0A5F8H2F4 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/13616:AGK ^@ http://purl.uniprot.org/uniprot/F7G5C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AGK family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/13616:LOC100021874 ^@ http://purl.uniprot.org/uniprot/F7FF58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/13616:RPN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1J6|||http://purl.uniprot.org/uniprot/A0A5F8H4T9|||http://purl.uniprot.org/uniprot/F6VUZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/13616:AOC2 ^@ http://purl.uniprot.org/uniprot/F6TKB8 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/13616:ADAMTS3 ^@ http://purl.uniprot.org/uniprot/F7EC85 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:AFG3L2 ^@ http://purl.uniprot.org/uniprot/F7CBD6 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/13616:TECR ^@ http://purl.uniprot.org/uniprot/F7G517 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100021854 ^@ http://purl.uniprot.org/uniprot/F6PZN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100023754 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNF9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/13616:PEPD ^@ http://purl.uniprot.org/uniprot/F7DI23|||http://purl.uniprot.org/uniprot/K7E536 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/13616:ZHX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/13616:CROT ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Z6 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/13616:SLIT3 ^@ http://purl.uniprot.org/uniprot/F6RCT0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:CHST6 ^@ http://purl.uniprot.org/uniprot/F7GEI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/13616:TMCO1 ^@ http://purl.uniprot.org/uniprot/F7FWC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Homodimer and homotetramer. Homodimer under resting conditions; forms homotetramers following and ER calcium overload.|||Membrane http://togogenome.org/gene/13616:LOC100027128 ^@ http://purl.uniprot.org/uniprot/F7GL76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:SH3PXD2B ^@ http://purl.uniprot.org/uniprot/A0A5F8G9T6|||http://purl.uniprot.org/uniprot/F7BRI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3PXD2 family.|||Cytoplasm|||podosome http://togogenome.org/gene/13616:LOC100017512 ^@ http://purl.uniprot.org/uniprot/F6PZ80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FBXO45 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNK2 ^@ Similarity ^@ Belongs to the FBXO45/Fsn family. http://togogenome.org/gene/13616:SLC52A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/13616:KEG11_p08 ^@ http://purl.uniprot.org/uniprot/Q65CI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SNAP25 ^@ http://purl.uniprot.org/uniprot/A0A5F8G776|||http://purl.uniprot.org/uniprot/F6VM87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Membrane|||Part of the SNARE core complex containing SNAP25, VAMP2 and STX1A; this complex binds CPLX1. Found in a complex containing SYT1, SV2B and syntaxin-1. Found in a ternary complex with STX1A and VAMP8. Interacts with HSC70 and with SYT9, forming a complex with DNAJC5. The interaction with SYT9 is inhibited in presence of calcium. Isoform 1 and isoform 2 interact with BLOC1S6. Interacts with CENPF. Interacts with EQTN. Interacts with HGS. Interacts with KCNB1 (via N-terminus); reduces the voltage-dependent potassium channel KCNB1 activity in pancreatic beta cells. Interacts with OTOF. Interacts with RIMS1. Interacts with SNAPIN. Interacts with STXBP6. Interacts with TRIM9. Interacts with ZDHHC13 (via ANK repeats). Interacts with ZDHHC17 (via ANK repeats). Associates with the BLOC-1 complex. Interacts with PLCL1 (via C2 domain). Interacts with PRRT2; this interaction may impair the formation of the SNARE complex. Interacts with alpha-synuclein/SNCA. Interacts with PRPH2. Interacts with ROM1. Interacts with STX3.|||Photoreceptor inner segment|||synaptosome|||t-SNARE involved in the molecular regulation of neurotransmitter release. Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion. Regulates plasma membrane recycling through its interaction with CENPF. Modulates the gating characteristics of the delayed rectifier voltage-dependent potassium channel KCNB1 in pancreatic beta cells. http://togogenome.org/gene/13616:TP53I11 ^@ http://purl.uniprot.org/uniprot/F6RQR2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:KAT8 ^@ http://purl.uniprot.org/uniprot/F6SP03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/13616:PDS5B ^@ http://purl.uniprot.org/uniprot/A0A5F8G3Z4 ^@ Similarity ^@ Belongs to the PDS5 family. http://togogenome.org/gene/13616:HACD4 ^@ http://purl.uniprot.org/uniprot/F7AZ94 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:GABRA3 ^@ http://purl.uniprot.org/uniprot/F6S4X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:TBCC ^@ http://purl.uniprot.org/uniprot/F7FP07 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCC family.|||Cytoplasm|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state. http://togogenome.org/gene/13616:SUPT6H ^@ http://purl.uniprot.org/uniprot/F6RZE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/13616:ASPHD2 ^@ http://purl.uniprot.org/uniprot/F7CKH2 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/13616:LOC100024663 ^@ http://purl.uniprot.org/uniprot/F6Q355 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HSPB7 ^@ http://purl.uniprot.org/uniprot/F6VA14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Nucleus http://togogenome.org/gene/13616:CHN1 ^@ http://purl.uniprot.org/uniprot/F7FZD5 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/13616:TCEANC ^@ http://purl.uniprot.org/uniprot/A0A5F8HLS0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GFRA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJZ0|||http://purl.uniprot.org/uniprot/F6SZS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for neurturin. Mediates the NRTN-induced autophosphorylation and activation of the RET receptor. Also able to mediate GDNF signaling through the RET tyrosine kinase receptor. http://togogenome.org/gene/13616:BMP7 ^@ http://purl.uniprot.org/uniprot/F7A479 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:MRS2 ^@ http://purl.uniprot.org/uniprot/F6QWC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:DIEXF ^@ http://purl.uniprot.org/uniprot/A0A5F8G791|||http://purl.uniprot.org/uniprot/F7GFB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/13616:LOC100022446 ^@ http://purl.uniprot.org/uniprot/F7A7S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLAIN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXM4|||http://purl.uniprot.org/uniprot/F7EN68 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/13616:GPRC5B ^@ http://purl.uniprot.org/uniprot/A0A5F8GBM7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:NOV ^@ http://purl.uniprot.org/uniprot/F7DSB8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:NUP35 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8G8|||http://purl.uniprot.org/uniprot/F7GI14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/13616:EXTL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H056 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:TMEM255B ^@ http://purl.uniprot.org/uniprot/A0A5F8GBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM255 family.|||Membrane http://togogenome.org/gene/13616:DAPK3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHR2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:monDomV1R1213 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NDUFA8 ^@ http://purl.uniprot.org/uniprot/F6TTD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/13616:HNRNPK ^@ http://purl.uniprot.org/uniprot/A0A5F8GCK3|||http://purl.uniprot.org/uniprot/A0A5F8HKB8|||http://purl.uniprot.org/uniprot/F7BUQ2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm|||podosome http://togogenome.org/gene/13616:GPRC5D ^@ http://purl.uniprot.org/uniprot/A0A5F8GYT4|||http://purl.uniprot.org/uniprot/A0A5F8GZC9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100010216 ^@ http://purl.uniprot.org/uniprot/F6Q499 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/13616:RING1 ^@ http://purl.uniprot.org/uniprot/F6U7L7 ^@ Function|||Subcellular Location Annotation ^@ Constitutes one of the E3 ubiquitin-protein ligases that mediate monoubiquitination of 'Lys-119' of histone H2A, thereby playing a central role in histone code and gene regulation. H2A 'Lys-119' ubiquitination gives a specific tag for epigenetic transcriptional repression and participates in X chromosome inactivation of female mammals. Essential component of a Polycomb group (PcG) multiprotein PRC1-like complex, a complex class required to maintain the transcriptionally repressive state of many genes, including Hox genes, throughout development. PcG PRC1 complex acts via chromatin remodeling and modification of histones, rendering chromatin heritably changed in its expressibility. Compared to RNF2/RING2, it does not have the main E3 ubiquitin ligase activity on histone H2A, and it may rather act as a modulator of RNF2/RING2 activity.|||Nucleus speckle http://togogenome.org/gene/13616:GDPD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB23|||http://purl.uniprot.org/uniprot/F7A3Y6 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/13616:DCBLD1 ^@ http://purl.uniprot.org/uniprot/F7CFE9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TMTC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/13616:FAM26E ^@ http://purl.uniprot.org/uniprot/F6Z8U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/13616:LOC100033166 ^@ http://purl.uniprot.org/uniprot/F6WLG1 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:PARP3 ^@ http://purl.uniprot.org/uniprot/F7CBC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/13616:PRPF3 ^@ http://purl.uniprot.org/uniprot/K7E1G2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). http://togogenome.org/gene/13616:MYBL1 ^@ http://purl.uniprot.org/uniprot/F7DRE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DPYD ^@ http://purl.uniprot.org/uniprot/F6VWD0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/13616:PGPEP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/13616:LOC100024128 ^@ http://purl.uniprot.org/uniprot/F7EI19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100617719 ^@ http://purl.uniprot.org/uniprot/F6XGN8 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:IFT43 ^@ http://purl.uniprot.org/uniprot/F7GGD2 ^@ Similarity ^@ Belongs to the IFT43 family. http://togogenome.org/gene/13616:SLC6A14 ^@ http://purl.uniprot.org/uniprot/F6W9U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:SDR42E1 ^@ http://purl.uniprot.org/uniprot/F7CET2 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/13616:SLC26A4 ^@ http://purl.uniprot.org/uniprot/F7F6U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane|||Sodium-independent transporter of chloride and iodide. http://togogenome.org/gene/13616:PTGER2 ^@ http://purl.uniprot.org/uniprot/F7A5D2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CD74 ^@ http://purl.uniprot.org/uniprot/K7E537 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GTF2A1L ^@ http://purl.uniprot.org/uniprot/A0A5F8GHD2|||http://purl.uniprot.org/uniprot/A0A5F8GNG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/13616:WRNIP1 ^@ http://purl.uniprot.org/uniprot/F6PFR8|||http://purl.uniprot.org/uniprot/F7DJS2 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/13616:SERPINC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGH4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/13616:SLC45A3 ^@ http://purl.uniprot.org/uniprot/F6T5F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ANXA2 ^@ http://purl.uniprot.org/uniprot/F6UHK2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Membrane|||basement membrane http://togogenome.org/gene/13616:FZD5 ^@ http://purl.uniprot.org/uniprot/F7G1W9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Membrane http://togogenome.org/gene/13616:CCDC181 ^@ http://purl.uniprot.org/uniprot/F6PNZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/13616:TM4SF4 ^@ http://purl.uniprot.org/uniprot/F6T2Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/13616:BRPF1 ^@ http://purl.uniprot.org/uniprot/F7A3V4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDU4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:LOC100014107 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R622 ^@ http://purl.uniprot.org/uniprot/F6TKF8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/F7AJC4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DUSP10 ^@ http://purl.uniprot.org/uniprot/F6U725 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:H3F3A ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ95 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:PARD6B ^@ http://purl.uniprot.org/uniprot/F7F794 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR6 family.|||Cytoplasm|||tight junction http://togogenome.org/gene/13616:AARSD1 ^@ http://purl.uniprot.org/uniprot/F7F360 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/13616:TOM1L2 ^@ http://purl.uniprot.org/uniprot/F6U836 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/13616:TEK ^@ http://purl.uniprot.org/uniprot/F6TEV1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:BARHL2 ^@ http://purl.uniprot.org/uniprot/F7GF75 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GAL3ST4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3B3|||http://purl.uniprot.org/uniprot/F6W8W2 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/13616:PTK6 ^@ http://purl.uniprot.org/uniprot/F6Y152 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:SSTR4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RANBP10 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6J2|||http://purl.uniprot.org/uniprot/F7CZC7 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/13616:PSMC3IP ^@ http://purl.uniprot.org/uniprot/A0A5F8H0X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/13616:LOC100022972 ^@ http://purl.uniprot.org/uniprot/F7DGA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100015275 ^@ http://purl.uniprot.org/uniprot/F7DQA8 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/13616:VN2R600 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE34 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100619430 ^@ http://purl.uniprot.org/uniprot/F7FAF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H848 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/13616:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/F6VGY3 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/13616:T2R3D ^@ http://purl.uniprot.org/uniprot/Q2ABA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:LOC100017458 ^@ http://purl.uniprot.org/uniprot/F6ZUA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CDK5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD62|||http://purl.uniprot.org/uniprot/F6VW45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:RAPGEF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8H891|||http://purl.uniprot.org/uniprot/A0A5F8HFI1 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/13616:TSEN15 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK87 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/13616:FITM2 ^@ http://purl.uniprot.org/uniprot/F7FM06 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:NCK2 ^@ http://purl.uniprot.org/uniprot/F7ALW1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/13616:PGM2 ^@ http://purl.uniprot.org/uniprot/F7B0S5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/13616:CHMP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSW5 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:P2RY8 ^@ http://purl.uniprot.org/uniprot/F6QS84 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:TIPIN ^@ http://purl.uniprot.org/uniprot/F6XSL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/13616:UFC1 ^@ http://purl.uniprot.org/uniprot/F7E6W2 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UFC1 subfamily.|||E1-like enzyme which specifically catalyzes the second step in ufmylation. Ufmylation is involved in reticulophagy (also called ER-phagy) induced in response to endoplasmic reticulum stress. http://togogenome.org/gene/13616:LOC100015828 ^@ http://purl.uniprot.org/uniprot/F6W669 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics.|||Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane|||Interacts with chaperones HSP70 and HSP90; this interaction is required for initial targeting to mitochondria.|||Microsome membrane|||Mitochondrion inner membrane|||The omega-1 hydroxylase activity is stimulated by cytochrome b5. http://togogenome.org/gene/13616:ADAM23 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYE7|||http://purl.uniprot.org/uniprot/F7EGE6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GAL ^@ http://purl.uniprot.org/uniprot/F6SIR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/13616:DESI2 ^@ http://purl.uniprot.org/uniprot/F7CDN2 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/13616:C3AR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with VGF-derived peptide TLQP-21.|||Membrane|||Receptor for the chemotactic and inflammatory peptide anaphylatoxin C3a. This receptor stimulates chemotaxis, granule enzyme release and superoxide anion production. http://togogenome.org/gene/13616:ACVR1C ^@ http://purl.uniprot.org/uniprot/F6SV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/13616:NKX2-1 ^@ http://purl.uniprot.org/uniprot/F6UZ04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LPCAT3 ^@ http://purl.uniprot.org/uniprot/F7CCY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CPSF4 ^@ http://purl.uniprot.org/uniprot/F7FVV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/13616:HIGD2A ^@ http://purl.uniprot.org/uniprot/F7A2A2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/13616:KCNJ2 ^@ http://purl.uniprot.org/uniprot/F7F885 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ2 subfamily.|||Membrane http://togogenome.org/gene/13616:COQ9 ^@ http://purl.uniprot.org/uniprot/F7D6L5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/13616:NR0B2 ^@ http://purl.uniprot.org/uniprot/F7BH57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:RBX1 ^@ http://purl.uniprot.org/uniprot/F7G0U6 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/13616:SKOR2 ^@ http://purl.uniprot.org/uniprot/F6ZP40 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/13616:EFNB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI99 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100022035 ^@ http://purl.uniprot.org/uniprot/F7B4P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:YPEL5 ^@ http://purl.uniprot.org/uniprot/F6VI71 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/13616:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQD8|||http://purl.uniprot.org/uniprot/F7C0S7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/13616:CMAS ^@ http://purl.uniprot.org/uniprot/F7EKV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CMP-NeuNAc synthase family.|||Catalyzes the activation of N-acetylneuraminic acid (NeuNAc) to cytidine 5'-monophosphate N-acetylneuraminic acid (CMP-NeuNAc), a substrate required for the addition of sialic acid. Has some activity toward NeuNAc, N-glycolylneuraminic acid (Neu5Gc) or 2-keto-3-deoxy-D-glycero-D-galacto-nononic acid (KDN).|||Homotetramer; the active enzyme is formed by a dimer of dimers. http://togogenome.org/gene/13616:PRPF38B ^@ http://purl.uniprot.org/uniprot/F7GLK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||May be required for pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/13616:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G657 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucagon family.|||Interacts with ADCYAP1R1 (via N-terminal extracellular domain).|||Secreted http://togogenome.org/gene/13616:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAN1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:PUS3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1Y4 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/13616:PPT1 ^@ http://purl.uniprot.org/uniprot/F6Z4J7 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/13616:MARCO ^@ http://purl.uniprot.org/uniprot/F6UT87 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:WSCD2 ^@ http://purl.uniprot.org/uniprot/F7B5Z5 ^@ Similarity ^@ Belongs to the WSCD family. http://togogenome.org/gene/13616:C1H14orf1 ^@ http://purl.uniprot.org/uniprot/F6QD91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CASR ^@ http://purl.uniprot.org/uniprot/F6PW91 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:POLR2K ^@ http://purl.uniprot.org/uniprot/A0A5F8HKA0 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/13616:PSKH1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G949|||http://purl.uniprot.org/uniprot/A0A5F8HFX4|||http://purl.uniprot.org/uniprot/F7CGY5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:MPHOSPH10 ^@ http://purl.uniprot.org/uniprot/F7CBK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Component of the 60-80S U3 small nucleolar ribonucleoprotein (U3 snoRNP). Required for the early cleavages during pre-18S ribosomal RNA processing.|||nucleolus http://togogenome.org/gene/13616:LOC100019315 ^@ http://purl.uniprot.org/uniprot/F6YZ91 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/13616:TM2D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ATP10D ^@ http://purl.uniprot.org/uniprot/F6ZB11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100013696 ^@ http://purl.uniprot.org/uniprot/F7C1Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DAO ^@ http://purl.uniprot.org/uniprot/A0A5F8HE10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/13616:ETNPPL ^@ http://purl.uniprot.org/uniprot/A0A5F8GS08|||http://purl.uniprot.org/uniprot/F7A071 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/13616:LOC100021318 ^@ http://purl.uniprot.org/uniprot/F6Q1U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SDC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/13616:VN2R613 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIQ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TRAPPC2L ^@ http://purl.uniprot.org/uniprot/F7D8N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/13616:LOC100030024 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NOP16 ^@ http://purl.uniprot.org/uniprot/F7A1U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP16 family.|||nucleolus http://togogenome.org/gene/13616:LOC100024563 ^@ http://purl.uniprot.org/uniprot/F7F6A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ACAA2 ^@ http://purl.uniprot.org/uniprot/F7FBH6 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/13616:GRB2 ^@ http://purl.uniprot.org/uniprot/F7B0Q0 ^@ Subcellular Location Annotation ^@ Endosome|||Golgi apparatus|||Nucleus http://togogenome.org/gene/13616:CCNL1 ^@ http://purl.uniprot.org/uniprot/F7DGG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin L subfamily.|||Nucleus speckle|||nucleoplasm http://togogenome.org/gene/13616:NFIB ^@ http://purl.uniprot.org/uniprot/A0A5F8GI82|||http://purl.uniprot.org/uniprot/F6RH94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/13616:MPPED2 ^@ http://purl.uniprot.org/uniprot/F7BK04 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/13616:ZNF703 ^@ http://purl.uniprot.org/uniprot/F7FJ52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/13616:ERLIN2 ^@ http://purl.uniprot.org/uniprot/F7FJD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the band 7/mec-2 family.|||Endoplasmic reticulum membrane|||Mediates the endoplasmic reticulum-associated degradation (ERAD) of inositol 1,4,5-trisphosphate receptors (IP3Rs). Involved in regulation of cellular cholesterol homeostasis by regulation the SREBP signaling pathway.|||Membrane http://togogenome.org/gene/13616:SLC7A9 ^@ http://purl.uniprot.org/uniprot/F6YGR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100025574 ^@ http://purl.uniprot.org/uniprot/F7C7J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PNRC family. PNRC2 subfamily.|||Nucleus|||P-body http://togogenome.org/gene/13616:EIF2B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWI8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/13616:PEX5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/F6QD02 ^@ Subcellular Location Annotation ^@ Membrane|||trans-Golgi network membrane http://togogenome.org/gene/13616:ERGIC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4L1|||http://purl.uniprot.org/uniprot/F6WZ15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/13616:T2R7B ^@ http://purl.uniprot.org/uniprot/Q2AB99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:EIF2B5 ^@ http://purl.uniprot.org/uniprot/F6VG26 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/13616:CA5A ^@ http://purl.uniprot.org/uniprot/F6W8Y6 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:LOC107651925 ^@ http://purl.uniprot.org/uniprot/F7BY71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/F7CUD2 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/13616:WDR76 ^@ http://purl.uniprot.org/uniprot/F7EL35 ^@ Function|||Similarity|||Subunit ^@ Belongs to the WD repeat DDB2/WDR76 family.|||Interacts with CUL4A and/or CUL4B.|||Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/13616:MR1 ^@ http://purl.uniprot.org/uniprot/F7CDQ3 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:SRPRB ^@ http://purl.uniprot.org/uniprot/F7BRN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:SLC35B4 ^@ http://purl.uniprot.org/uniprot/F6X316 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Membrane http://togogenome.org/gene/13616:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A5F8GKY8|||http://purl.uniprot.org/uniprot/K7E5W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:RTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H315 ^@ Similarity|||Subunit ^@ Belongs to the rtf2 family.|||Interacts with DDI2; probably also interacts with DDI1. http://togogenome.org/gene/13616:PAF1 ^@ http://purl.uniprot.org/uniprot/F7F917 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/13616:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A5F8G466 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:INCENP ^@ http://purl.uniprot.org/uniprot/F6T654 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/13616:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRK7|||http://purl.uniprot.org/uniprot/F6T6L9 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/13616:NAAA ^@ http://purl.uniprot.org/uniprot/F6ZHY7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acid ceramidase family.|||Heterodimer.|||Lysosome http://togogenome.org/gene/13616:LOC100014496 ^@ http://purl.uniprot.org/uniprot/F7G7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/13616:LOC100020842 ^@ http://purl.uniprot.org/uniprot/F7EV69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:ARHGDIB ^@ http://purl.uniprot.org/uniprot/F7E3S1 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/13616:LOXL3 ^@ http://purl.uniprot.org/uniprot/F7FDE6 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/13616:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG39|||http://purl.uniprot.org/uniprot/F7GF19 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:EPCAM ^@ http://purl.uniprot.org/uniprot/F7GI03 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LDB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEZ5|||http://purl.uniprot.org/uniprot/F6V1M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB family.|||Nucleus http://togogenome.org/gene/13616:HOXA3 ^@ http://purl.uniprot.org/uniprot/F7BGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:PTP4A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5L6 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:LOC103100354 ^@ http://purl.uniprot.org/uniprot/F6XPJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:NHS ^@ http://purl.uniprot.org/uniprot/A0A5F8HDE7 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/13616:LOC100619573 ^@ http://purl.uniprot.org/uniprot/F6RZD4 ^@ Similarity ^@ Belongs to the FAM47 family. http://togogenome.org/gene/13616:NOS3 ^@ http://purl.uniprot.org/uniprot/F6S3S1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/13616:PTGES ^@ http://purl.uniprot.org/uniprot/A0A5F8H8C0|||http://purl.uniprot.org/uniprot/F7BTI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/13616:LANCL2 ^@ http://purl.uniprot.org/uniprot/F7G210 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/13616:AKAP5 ^@ http://purl.uniprot.org/uniprot/F7FZI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPS2 ^@ http://purl.uniprot.org/uniprot/F7G9G8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. http://togogenome.org/gene/13616:NDRG1 ^@ http://purl.uniprot.org/uniprot/F7DPF6 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/13616:RAB3B ^@ http://purl.uniprot.org/uniprot/A0A5F8H3C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/13616:MRPS15 ^@ http://purl.uniprot.org/uniprot/F6ZXY2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/13616:FKRP ^@ http://purl.uniprot.org/uniprot/F6QQI6 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/13616:LOC103101138 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH60|||http://purl.uniprot.org/uniprot/K7E274 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/13616:PGM5 ^@ http://purl.uniprot.org/uniprot/F6WUY4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/13616:LOC100023079 ^@ http://purl.uniprot.org/uniprot/F6U8J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103097074 ^@ http://purl.uniprot.org/uniprot/K7E2F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/13616:PUF60 ^@ http://purl.uniprot.org/uniprot/F7ADW1|||http://purl.uniprot.org/uniprot/F7ADX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM half pint family.|||Nucleus http://togogenome.org/gene/13616:LBX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSD2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SEC13 ^@ http://purl.uniprot.org/uniprot/F7GFQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane|||nuclear pore complex http://togogenome.org/gene/13616:SEC31B ^@ http://purl.uniprot.org/uniprot/A0A5F8GUS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:IL10RB ^@ http://purl.uniprot.org/uniprot/F6V1X5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/13616:HNRNPA2B1 ^@ http://purl.uniprot.org/uniprot/F6TBC0 ^@ Subcellular Location Annotation ^@ Cytoplasmic granule http://togogenome.org/gene/13616:TVP23A ^@ http://purl.uniprot.org/uniprot/F7E7H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/13616:LOC100031885 ^@ http://purl.uniprot.org/uniprot/F7CHZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EPHA4 ^@ http://purl.uniprot.org/uniprot/F6XVY7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/13616:DES ^@ http://purl.uniprot.org/uniprot/F7BWE5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/13616:ATXN2L ^@ http://purl.uniprot.org/uniprot/F6PIC6 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/13616:AP1S2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/13616:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A5F8GGB6 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/13616:UHRF1 ^@ http://purl.uniprot.org/uniprot/F7DPG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ANPEP ^@ http://purl.uniprot.org/uniprot/F6UV20 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:LRRC8A ^@ http://purl.uniprot.org/uniprot/F7F2H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GAREM1 ^@ http://purl.uniprot.org/uniprot/F7BZ87 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/13616:SPTAN1 ^@ http://purl.uniprot.org/uniprot/F6TSC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/13616:FUS ^@ http://purl.uniprot.org/uniprot/F6WGL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TET family.|||Nucleus http://togogenome.org/gene/13616:LPIN3 ^@ http://purl.uniprot.org/uniprot/F7AZN5 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/13616:TENM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:DCHS2 ^@ http://purl.uniprot.org/uniprot/F7GH79 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:TRMT1 ^@ http://purl.uniprot.org/uniprot/F6UGF2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/13616:LHCGR ^@ http://purl.uniprot.org/uniprot/A0A5F8G897|||http://purl.uniprot.org/uniprot/A0A5F8H063|||http://purl.uniprot.org/uniprot/F7FX19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for lutropin-choriogonadotropic hormone. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. http://togogenome.org/gene/13616:KDELR2 ^@ http://purl.uniprot.org/uniprot/F7ETG7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:BYSL ^@ http://purl.uniprot.org/uniprot/F7DYQ6 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/13616:ACAD11 ^@ http://purl.uniprot.org/uniprot/F7G3S4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:HAS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NodC/HAS family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane http://togogenome.org/gene/13616:LOC100009862 ^@ http://purl.uniprot.org/uniprot/F6PJY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PGPEP1L ^@ http://purl.uniprot.org/uniprot/F6SIL8 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/13616:CAT ^@ http://purl.uniprot.org/uniprot/F6Y8K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Peroxisome http://togogenome.org/gene/13616:RRP12 ^@ http://purl.uniprot.org/uniprot/F6X6Z7 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/13616:MYLK ^@ http://purl.uniprot.org/uniprot/A0A5F8H252|||http://purl.uniprot.org/uniprot/F6PR65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/13616:HBA ^@ http://purl.uniprot.org/uniprot/Q8HY34 ^@ Function|||Similarity|||Subunit|||Tissue Specificity ^@ Belongs to the globin family.|||Hemopressin acts as an antagonist peptide of the cannabinoid receptor CNR1. Hemopressin-binding efficiently blocks cannabinoid receptor CNR1 and subsequent signaling.|||Heterotetramer of two alpha chains and two beta chains.|||Involved in oxygen transport from the lung to the various peripheral tissues.|||Red blood cells. http://togogenome.org/gene/13616:CPT2 ^@ http://purl.uniprot.org/uniprot/F6UAM7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/13616:KCNK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLM4|||http://purl.uniprot.org/uniprot/A0A5F8HD04|||http://purl.uniprot.org/uniprot/F7DDK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:AXIN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G304|||http://purl.uniprot.org/uniprot/F7G701 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/13616:VWC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2A8 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/13616:CCDC94 ^@ http://purl.uniprot.org/uniprot/F6RPP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/13616:TSPOAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM78|||http://purl.uniprot.org/uniprot/A0A5F8GX99|||http://purl.uniprot.org/uniprot/F7E3H7 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/13616:LOC100023310 ^@ http://purl.uniprot.org/uniprot/F6Q111 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DYDC2 ^@ http://purl.uniprot.org/uniprot/K7DYW9 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/13616:TTLL9 ^@ http://purl.uniprot.org/uniprot/F7DEP8 ^@ Similarity ^@ Belongs to the tubulin--tyrosine ligase family. http://togogenome.org/gene/13616:GATC ^@ http://purl.uniprot.org/uniprot/F6WEJ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/13616:NDUFA13 ^@ http://purl.uniprot.org/uniprot/F6X8Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:ZDHHC12 ^@ http://purl.uniprot.org/uniprot/F6TT20 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:LOC100012857 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3Q8 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:SMAD5 ^@ http://purl.uniprot.org/uniprot/F7CFQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:PACS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLN1 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/13616:DSG2 ^@ http://purl.uniprot.org/uniprot/F7EP22 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/13616:TMED3 ^@ http://purl.uniprot.org/uniprot/F6SFJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:KCNJ16 ^@ http://purl.uniprot.org/uniprot/F7F889 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/13616:RGS7BP ^@ http://purl.uniprot.org/uniprot/F6XPX0 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/13616:RHPN2 ^@ http://purl.uniprot.org/uniprot/F6Z6B8 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/13616:GALNT11 ^@ http://purl.uniprot.org/uniprot/F6QH16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:EBPL ^@ http://purl.uniprot.org/uniprot/A0A5F8HAF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFL3|||http://purl.uniprot.org/uniprot/A0A5F8HFV1|||http://purl.uniprot.org/uniprot/F7E9X7 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/13616:MYOC ^@ http://purl.uniprot.org/uniprot/A0A5F8HHZ8 ^@ Caution|||Subcellular Location Annotation ^@ Endoplasmic reticulum|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion intermembrane space|||Mitochondrion outer membrane|||Rough endoplasmic reticulum|||cilium|||extracellular exosome|||extracellular matrix http://togogenome.org/gene/13616:POLB ^@ http://purl.uniprot.org/uniprot/F6STA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Cytoplasm|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus|||Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. http://togogenome.org/gene/13616:PPP2R5E ^@ http://purl.uniprot.org/uniprot/F7FRM5 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/13616:TCTN3 ^@ http://purl.uniprot.org/uniprot/F7FKZ3 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/13616:LOC100012206 ^@ http://purl.uniprot.org/uniprot/F6WN53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/13616:LOC100017083 ^@ http://purl.uniprot.org/uniprot/F6TC73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NR1D1 ^@ http://purl.uniprot.org/uniprot/F7BNH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:ITGB3BP ^@ http://purl.uniprot.org/uniprot/A0A5F8G4M0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription coregulator that can have both coactivator and corepressor functions.|||centromere|||kinetochore http://togogenome.org/gene/13616:LOC100033060 ^@ http://purl.uniprot.org/uniprot/F6UUX0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:ARL11 ^@ http://purl.uniprot.org/uniprot/F6X0M1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:ACTR8 ^@ http://purl.uniprot.org/uniprot/F6Q1G3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/13616:SGSM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4X7 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/13616:LOC100030353 ^@ http://purl.uniprot.org/uniprot/F7F1K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100013073 ^@ http://purl.uniprot.org/uniprot/F6SR91 ^@ Similarity ^@ Belongs to the TCAF family. http://togogenome.org/gene/13616:CAV2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola http://togogenome.org/gene/13616:C1H14orf169 ^@ http://purl.uniprot.org/uniprot/F6YQ19 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family.|||Binds 1 Fe(2+) ion per subunit.|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.|||nucleolus http://togogenome.org/gene/13616:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/F7D678 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:SLC12A8 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFT4|||http://purl.uniprot.org/uniprot/F6RFS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/13616:VN2R558 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY97 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:CAMK2G ^@ http://purl.uniprot.org/uniprot/A0A5F8G3G1|||http://purl.uniprot.org/uniprot/A0A5F8GKJ5|||http://purl.uniprot.org/uniprot/A0A5F8GUM4|||http://purl.uniprot.org/uniprot/A0A5F8H3M4|||http://purl.uniprot.org/uniprot/A0A5F8H6A9|||http://purl.uniprot.org/uniprot/A0A5F8HHE1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/13616:DUOXA2 ^@ http://purl.uniprot.org/uniprot/F7GFZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/13616:TMEM165 ^@ http://purl.uniprot.org/uniprot/F7DL81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/13616:LOC100017675 ^@ http://purl.uniprot.org/uniprot/F6T3A4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/13616:RNF40 ^@ http://purl.uniprot.org/uniprot/F6SQS9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BRE1 family.|||Component of the RNF20/40 complex (also known as BRE1 complex) probably composed of 2 copies of RNF20/BRE1A and 2 copies of RNF40/BRE1B. Interacts with UBE2E1/UBCH6.|||Nucleus http://togogenome.org/gene/13616:TMEM30B ^@ http://purl.uniprot.org/uniprot/F6ZFS9 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/13616:CNOT10 ^@ http://purl.uniprot.org/uniprot/A0A5F8H133|||http://purl.uniprot.org/uniprot/A0A5F8HGY2|||http://purl.uniprot.org/uniprot/F6V3V4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT10 family.|||Component of the CCR4-NOT complex which is one of the major cellular mRNA deadenylases and is linked to various cellular processes including bulk mRNA degradation, miRNA-mediated repression, translational repression during translational initiation and general transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DHODH ^@ http://purl.uniprot.org/uniprot/A0A5F8H9U5|||http://purl.uniprot.org/uniprot/F7BVX3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:NXT2 ^@ http://purl.uniprot.org/uniprot/F6V2I5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/13616:ARSA ^@ http://purl.uniprot.org/uniprot/F7FF08 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:GDF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDU6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:TADA1 ^@ http://purl.uniprot.org/uniprot/F7ANA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TADA1 family.|||Component of the STAGA transcription coactivator-HAT complex, at least composed of SUPT3H, GCN5L2, TAF5L, TAF6L, SUPT7L, TADA3L, TAD1L, TAF10, TAF12, TRRAP and TAF9.|||Nucleus|||Probably involved in transcriptional regulation. http://togogenome.org/gene/13616:LGSN ^@ http://purl.uniprot.org/uniprot/A0A5F8GG75|||http://purl.uniprot.org/uniprot/F7FCL0 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/13616:RFT1 ^@ http://purl.uniprot.org/uniprot/F7D428 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/13616:PARL ^@ http://purl.uniprot.org/uniprot/F7FZ77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100017340 ^@ http://purl.uniprot.org/uniprot/F6TBR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC654275 ^@ http://purl.uniprot.org/uniprot/Q2V578 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:ISCA2 ^@ http://purl.uniprot.org/uniprot/F7FEC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/13616:monDomV1R1254 ^@ http://purl.uniprot.org/uniprot/F6V7I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100026811 ^@ http://purl.uniprot.org/uniprot/K7E5S2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space|||Plays a role in apoptosis. Suppression of the anti-apoptotic members or activation of the pro-apoptotic members of the Bcl-2 family leads to altered mitochondrial membrane permeability resulting in release of cytochrome c into the cytosol. Binding of cytochrome c to Apaf-1 triggers the activation of caspase-9, which then accelerates apoptosis by activating other caspases. http://togogenome.org/gene/13616:SLC9A3R2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYA2 ^@ Function|||Subcellular Location Annotation ^@ Endomembrane system|||Scaffold protein that connects plasma membrane proteins with members of the ezrin/moesin/radixin family and thereby helps to link them to the actin cytoskeleton and to regulate their surface expression. http://togogenome.org/gene/13616:THUMPD2 ^@ http://purl.uniprot.org/uniprot/F7EY46 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/13616:ZNF592 ^@ http://purl.uniprot.org/uniprot/A0A5F8HB00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:LOC100011905 ^@ http://purl.uniprot.org/uniprot/K7E0Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:BORCS7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Membrane http://togogenome.org/gene/13616:RPE65 ^@ http://purl.uniprot.org/uniprot/F6WL84 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/13616:LOC100016979 ^@ http://purl.uniprot.org/uniprot/F7AN53 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:TMEM8C ^@ http://purl.uniprot.org/uniprot/F7CS65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MASP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4W3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ZDHHC11 ^@ http://purl.uniprot.org/uniprot/K7E5H2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:LOC100016831 ^@ http://purl.uniprot.org/uniprot/F6Z632 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DNAJA2 ^@ http://purl.uniprot.org/uniprot/F7CT32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100020356 ^@ http://purl.uniprot.org/uniprot/F6PYV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100012978 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9K9 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:MCOLN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB17|||http://purl.uniprot.org/uniprot/A0A5F8GG67 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/13616:MRPL40 ^@ http://purl.uniprot.org/uniprot/F6XNB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/13616:GINS1 ^@ http://purl.uniprot.org/uniprot/F7EGJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex which is a heterotetramer of GINS1, GINS2, GINS3 and GINS4. Forms a stable subcomplex with GINS4. GINS complex interacts with DNA primase in vitro. Component of the CMG helicase complex, a hexameric ring of related MCM2-7 subunits stabilized by CDC45 and the tetrameric GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex is a core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/13616:TTC39C ^@ http://purl.uniprot.org/uniprot/F7G2N9 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/13616:TRAF2 ^@ http://purl.uniprot.org/uniprot/F6WWH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100010137 ^@ http://purl.uniprot.org/uniprot/F7FSW2 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/13616:HAPLN3 ^@ http://purl.uniprot.org/uniprot/F6QN25 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ARF6 ^@ http://purl.uniprot.org/uniprot/F7FYA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Cell membrane|||Cleavage furrow|||Endosome membrane|||Midbody ring|||Recycling endosome membrane|||filopodium membrane|||ruffle http://togogenome.org/gene/13616:PSMD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8P1 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/13616:POLR2I ^@ http://purl.uniprot.org/uniprot/F6U7C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/13616:LOC100017029 ^@ http://purl.uniprot.org/uniprot/F6WHI3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/13616:PTHLH ^@ http://purl.uniprot.org/uniprot/A0A5F8GKI1|||http://purl.uniprot.org/uniprot/F7BH65 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the parathyroid hormone family.|||Cytoplasm|||Neuroendocrine peptide which is a critical regulator of cellular and organ growth, development, migration, differentiation and survival and of epithelial calcium ion transport. Regulates endochondral bone development and epithelial-mesenchymal interactions during the formation of the mammary glands and teeth. Required for skeletal homeostasis. Promotes mammary mesenchyme differentiation and bud outgrowth by modulating mesenchymal cell responsiveness to BMPs. Up-regulates BMPR1A expression in the mammary mesenchyme and this increases the sensitivity of these cells to BMPs and allows them to respond to BMP4 in a paracrine and/or autocrine fashion. BMP4 signaling in the mesenchyme, in turn, triggers epithelial outgrowth and augments MSX2 expression, which causes the mammary mesenchyme to inhibit hair follicle formation within the nipple sheath.|||Nucleus|||Osteostatin is a potent inhibitor of osteoclastic bone resorption.|||PTHrP interacts with PTH1R (via N-terminal extracellular domain).|||Secreted|||There are several secretory forms, including osteostatin, arising from endoproteolytic cleavage of the initial translation product. Each of these secretory forms is believed to have one or more of its own receptors that mediates the normal paracrine, autocrine and endocrine actions. http://togogenome.org/gene/13616:OSBPL10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDR1 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/13616:HNF1B ^@ http://purl.uniprot.org/uniprot/F7F998 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/13616:RAPSN ^@ http://purl.uniprot.org/uniprot/A0A5F8GTM3 ^@ Similarity ^@ Belongs to the RAPsyn family. http://togogenome.org/gene/13616:TOE1 ^@ http://purl.uniprot.org/uniprot/F7E0E0 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/13616:VEPH1 ^@ http://purl.uniprot.org/uniprot/F7E0U4 ^@ Similarity ^@ Belongs to the MELT/VEPH family. http://togogenome.org/gene/13616:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/F7C727 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/13616:LOC100017693 ^@ http://purl.uniprot.org/uniprot/F6SRE9 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/13616:IDNK ^@ http://purl.uniprot.org/uniprot/A0A5F8GF33 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/13616:GLOD4 ^@ http://purl.uniprot.org/uniprot/F7D817 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/13616:TSSK6 ^@ http://purl.uniprot.org/uniprot/F6WPR1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:GKAP1 ^@ http://purl.uniprot.org/uniprot/F7FTQ9 ^@ Similarity ^@ Belongs to the GKAP1 family. http://togogenome.org/gene/13616:EBF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/13616:LOC100027959 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NHP2 ^@ http://purl.uniprot.org/uniprot/F6UBQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/13616:PPIH ^@ http://purl.uniprot.org/uniprot/F6WXM4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:BAMBI ^@ http://purl.uniprot.org/uniprot/F7CL00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/13616:C4HXorf36 ^@ http://purl.uniprot.org/uniprot/F6UJ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Secreted http://togogenome.org/gene/13616:PROS1 ^@ http://purl.uniprot.org/uniprot/F6UL60 ^@ Caution|||Function ^@ Anticoagulant plasma protein; it is a cofactor to activated protein C in the degradation of coagulation factors Va and VIIIa. It helps to prevent coagulation and stimulating fibrinolysis.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MAP7D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GV32|||http://purl.uniprot.org/uniprot/A0A5F8H8D1|||http://purl.uniprot.org/uniprot/F6Y4L1 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/13616:ASPM ^@ http://purl.uniprot.org/uniprot/A0A5F8G5R4|||http://purl.uniprot.org/uniprot/F6VH23 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100028839 ^@ http://purl.uniprot.org/uniprot/F7AKT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LPCAT2 ^@ http://purl.uniprot.org/uniprot/F7EVV8 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:IMP3 ^@ http://purl.uniprot.org/uniprot/F7C0I3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/13616:ADCK1 ^@ http://purl.uniprot.org/uniprot/F6ZCK3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/13616:CDADC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H477|||http://purl.uniprot.org/uniprot/F7A1J3 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/13616:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/A0A5F8H840 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GFAP ^@ http://purl.uniprot.org/uniprot/F6WYV7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the intermediate filament family.|||GFAP, a class-III intermediate filament, is a cell-specific marker that, during the development of the central nervous system, distinguishes astrocytes from other glial cells.|||Interacts with SYNM. http://togogenome.org/gene/13616:PSD ^@ http://purl.uniprot.org/uniprot/F7C6S5 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/13616:LAMB3 ^@ http://purl.uniprot.org/uniprot/F7BVU0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:FAM129B ^@ http://purl.uniprot.org/uniprot/F6Y3H2 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/13616:ZIC2 ^@ http://purl.uniprot.org/uniprot/F6W6Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:KRAS ^@ http://purl.uniprot.org/uniprot/Q07983 ^@ Activity Regulation|||Disease Annotation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).|||Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP). Interaction with SOS1 promotes exchange of bound GDP by GTP.|||Belongs to the small GTPase superfamily. Ras family.|||Cell membrane|||Interacts with PHLPP. Interacts (active GTP-bound form preferentially) with RGS14 (By similarity). Interacts (when farnesylated) with PDE6D; this promotes dissociation from the cell membrane (By similarity). Interacts with SOS1 (By similarity). Interacts (when farnesylated) with GPR31 (By similarity). Interacts with RAP1GDS1 (By similarity).|||Mutation which changes position 61 is implicated in ultraviolet radiation-induced (UVR-induced) eye tumor.|||Ras proteins bind GDP/GTP and possess intrinsic GTPase activity (By similarity). Plays an important role in the regulation of cell proliferation (PubMed:8312604). Plays a role in promoting oncogenic events by inducing transcriptional silencing of tumor suppressor genes (TSGs) in colorectal cancer (CRC) cells in a ZNF304-dependent manner (By similarity).|||cytosol http://togogenome.org/gene/13616:KEG11_p07 ^@ http://purl.uniprot.org/uniprot/Q65CI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/13616:LOC100023238 ^@ http://purl.uniprot.org/uniprot/F7EAX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TLE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4R4|||http://purl.uniprot.org/uniprot/A0A5F8GCB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/13616:LOC100618735 ^@ http://purl.uniprot.org/uniprot/F6S991 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ONECUT2 ^@ http://purl.uniprot.org/uniprot/F7AQF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/13616:LOC100012382 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX83 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/13616:BAK1 ^@ http://purl.uniprot.org/uniprot/F6R4F6 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:ATXN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYG4|||http://purl.uniprot.org/uniprot/F6Z719 ^@ Similarity ^@ Belongs to the ataxin-2 family. http://togogenome.org/gene/13616:LOC100013504 ^@ http://purl.uniprot.org/uniprot/F7C1Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RRAGC ^@ http://purl.uniprot.org/uniprot/F7FUI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/13616:EP300 ^@ http://purl.uniprot.org/uniprot/F7GG23 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:ATG4D ^@ http://purl.uniprot.org/uniprot/F6XG04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/13616:RNASEH2A ^@ http://purl.uniprot.org/uniprot/A0A5F8GEP9|||http://purl.uniprot.org/uniprot/F6XVJ9 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Catalytic subunit of RNase HII, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/13616:LOC100027752 ^@ http://purl.uniprot.org/uniprot/F7EG90 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/13616:BACE1 ^@ http://purl.uniprot.org/uniprot/F6QP52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/13616:ORMDL3 ^@ http://purl.uniprot.org/uniprot/F7GCE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Interacts with SPTLC1.|||Membrane|||Negative regulator of sphingolipid synthesis. May indirectly regulate endoplasmic reticulum-mediated Ca(+2) signaling. http://togogenome.org/gene/13616:APOH ^@ http://purl.uniprot.org/uniprot/F6QPV8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:PLK5 ^@ http://purl.uniprot.org/uniprot/F7FYD1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/13616:USP16 ^@ http://purl.uniprot.org/uniprot/F6RKK2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes.|||Homotetramer.|||Nucleus|||Phosphorylated at the onset of mitosis and dephosphorylated during the metaphase/anaphase transition. Phosphorylation by AURKB enhances the deubiquitinase activity.|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. In resting B- and T-lymphocytes, phosphorylation by AURKB leads to enhance its activity, thereby maintaining transcription in resting lymphocytes. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/13616:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUR3|||http://purl.uniprot.org/uniprot/A0A5F8HK88|||http://purl.uniprot.org/uniprot/F6TD14 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/13616:CDH15 ^@ http://purl.uniprot.org/uniprot/F7EBN5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ZCCHC6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDB1|||http://purl.uniprot.org/uniprot/F7GBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/13616:TBCB ^@ http://purl.uniprot.org/uniprot/F6U7B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCB family.|||Cytoplasm http://togogenome.org/gene/13616:MYSM1 ^@ http://purl.uniprot.org/uniprot/F7CU00 ^@ Similarity ^@ Belongs to the peptidase M67A family. MYSM1 subfamily. http://togogenome.org/gene/13616:GPT2 ^@ http://purl.uniprot.org/uniprot/F7CTM0 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/13616:FAM135B ^@ http://purl.uniprot.org/uniprot/A0A5F8H1P4 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/13616:EXOC7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCS8|||http://purl.uniprot.org/uniprot/F7FTY5 ^@ Function|||Similarity ^@ Belongs to the EXO70 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/13616:SGPL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLT5|||http://purl.uniprot.org/uniprot/F6RFM3 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/13616:HAPLN4 ^@ http://purl.uniprot.org/uniprot/F6UF93 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PPFIA4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIE2|||http://purl.uniprot.org/uniprot/A0A5F8HH77|||http://purl.uniprot.org/uniprot/F7E9P7 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/13616:PYGL ^@ http://purl.uniprot.org/uniprot/F7ACG9 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/13616:CPQ ^@ http://purl.uniprot.org/uniprot/F6PX15 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Carboxypeptidase that may play an important role in the hydrolysis of circulating peptides. Catalyzes the hydrolysis of dipeptides with unsubstituted terminals into amino acids. May play a role in the liberation of thyroxine hormone from its thyroglobulin (Tg) precursor.|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome|||Secreted http://togogenome.org/gene/13616:C1R ^@ http://purl.uniprot.org/uniprot/F7BU27 ^@ Caution|||Function|||Subunit ^@ C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.|||C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PMS1 ^@ http://purl.uniprot.org/uniprot/F6QXE7 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/13616:TFAP2C ^@ http://purl.uniprot.org/uniprot/A0A5F8GI09|||http://purl.uniprot.org/uniprot/F7A4W2 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/13616:MANBAL ^@ http://purl.uniprot.org/uniprot/F6WQZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/13616:NDUFA10 ^@ http://purl.uniprot.org/uniprot/F7F9D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA10 subunit family.|||Complex I is composed of 45 different subunits. This a component of the hydrophobic protein fraction.|||Mitochondrion matrix http://togogenome.org/gene/13616:DYX1C1 ^@ http://purl.uniprot.org/uniprot/F6ZW09 ^@ Subcellular Location Annotation ^@ Dynein axonemal particle|||neuron projection http://togogenome.org/gene/13616:LOC103094021 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMH6 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/13616:BMPR2 ^@ http://purl.uniprot.org/uniprot/F7AU53 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily. http://togogenome.org/gene/13616:PSPH ^@ http://purl.uniprot.org/uniprot/A0A5F8GAZ0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/13616:RIMKLA ^@ http://purl.uniprot.org/uniprot/A0A5F8HG24|||http://purl.uniprot.org/uniprot/F6XCL7 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/13616:LOC103094714 ^@ http://purl.uniprot.org/uniprot/F6X920 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/13616:PGLYRP2 ^@ http://purl.uniprot.org/uniprot/F6ZE34 ^@ Similarity ^@ Belongs to the N-acetylmuramoyl-L-alanine amidase 2 family. http://togogenome.org/gene/13616:HDX ^@ http://purl.uniprot.org/uniprot/A0A5F8GXA6|||http://purl.uniprot.org/uniprot/F6W4D6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LAMA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H112 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:IFT57 ^@ http://purl.uniprot.org/uniprot/F7GEN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/13616:LOC100026375 ^@ http://purl.uniprot.org/uniprot/F7ACW1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CAMK1 ^@ http://purl.uniprot.org/uniprot/F6YQ84 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:BCL2L13 ^@ http://purl.uniprot.org/uniprot/F7CU62 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:IFN4 ^@ http://purl.uniprot.org/uniprot/A8E6E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:FGB ^@ http://purl.uniprot.org/uniprot/F7FX25 ^@ Subcellular Location Annotation|||Subunit ^@ Heterohexamer; disulfide linked. Contains 2 sets of 3 non-identical chains (alpha, beta and gamma). The 2 heterotrimers are in head to head conformation with the N-termini in a small central domain.|||Secreted http://togogenome.org/gene/13616:GBX1 ^@ http://purl.uniprot.org/uniprot/F6T3S9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100020363 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100022769 ^@ http://purl.uniprot.org/uniprot/F6W186 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PTH1R ^@ http://purl.uniprot.org/uniprot/A0A5F8GXQ4|||http://purl.uniprot.org/uniprot/F6R731 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PFN2 ^@ http://purl.uniprot.org/uniprot/F6T2V7|||http://purl.uniprot.org/uniprot/F6T2W1 ^@ Function|||Similarity ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations. By binding to PIP2, it inhibits the formation of IP3 and DG. http://togogenome.org/gene/13616:MYOD1 ^@ http://purl.uniprot.org/uniprot/F7CCS4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/13616:LOC100023235 ^@ http://purl.uniprot.org/uniprot/F7G5J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochromes P450 are a group of heme-thiolate monooxygenases.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:TMEM11 ^@ http://purl.uniprot.org/uniprot/A0A5F8HH03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM11 family.|||Membrane|||Mitochondrion inner membrane|||Plays a role in mitochondrial morphogenesis. http://togogenome.org/gene/13616:GJB7 ^@ http://purl.uniprot.org/uniprot/F6ST34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:PSMA3 ^@ http://purl.uniprot.org/uniprot/F7ETB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:LOC100010723 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0D4 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/13616:ZCCHC4 ^@ http://purl.uniprot.org/uniprot/F6R8E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZCCHC4 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/13616:SCUBE1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GB34|||http://purl.uniprot.org/uniprot/A0A5F8HF65|||http://purl.uniprot.org/uniprot/F7CCK4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100010238 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/13616:NGB ^@ http://purl.uniprot.org/uniprot/Q3KN63 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:ZNF503 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/13616:SLC25A30 ^@ http://purl.uniprot.org/uniprot/F7FI91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100022225 ^@ http://purl.uniprot.org/uniprot/F6Q031 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DTNA ^@ http://purl.uniprot.org/uniprot/A0A5F8GEV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100009907 ^@ http://purl.uniprot.org/uniprot/F7F9V8 ^@ Function|||Subunit ^@ EF-1 is composed of four subunits: alpha, beta, delta, and gamma.|||Probably plays a role in anchoring the complex to other cellular components. http://togogenome.org/gene/13616:NMUR1 ^@ http://purl.uniprot.org/uniprot/F7BW40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/13616:PNPLA6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVK0|||http://purl.uniprot.org/uniprot/F7FHH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:LOC100013827 ^@ http://purl.uniprot.org/uniprot/F6PX60 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:ACSS3 ^@ http://purl.uniprot.org/uniprot/F7FIW5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:MAB21L2 ^@ http://purl.uniprot.org/uniprot/F6VDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mab-21 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:ELK3 ^@ http://purl.uniprot.org/uniprot/F7E9Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:DMRT3 ^@ http://purl.uniprot.org/uniprot/F7GL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/13616:CDH8 ^@ http://purl.uniprot.org/uniprot/F7EXZ6 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KATNAL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX49 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/13616:VN2R550 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ16 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:MCM8 ^@ http://purl.uniprot.org/uniprot/F7DTQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:SQLE ^@ http://purl.uniprot.org/uniprot/F6T5S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:CRYBA4 ^@ http://purl.uniprot.org/uniprot/F7CJE9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/13616:PPARGC1A ^@ http://purl.uniprot.org/uniprot/F6XM07 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/13616:VN2R541 ^@ http://purl.uniprot.org/uniprot/F7EBK0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ENPEP ^@ http://purl.uniprot.org/uniprot/F6TL25 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homodimer; disulfide-linked.|||Regulates central hypertension through its calcium-modulated preference to cleave N-terminal acidic residues from peptides such as angiotensin II. http://togogenome.org/gene/13616:CLUAP1 ^@ http://purl.uniprot.org/uniprot/F7ASW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/13616:SHC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5M6|||http://purl.uniprot.org/uniprot/F6TMP1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:CLP1 ^@ http://purl.uniprot.org/uniprot/F6U3G0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex, composed of CLP1, TSEN2, TSEN15, TSEN34 and TSEN54. Component of pre-mRNA cleavage complex II (CF-II). Also associates with numerous components of the pre-mRNA cleavage complex I (CF-I/CFIm), including NUDT21, CPSF2, CPSF3, CPSF6 and CPSF7. Interacts with CSTF2 and SYMPK.|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/13616:LOC100020573 ^@ http://purl.uniprot.org/uniprot/F7E8Y9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:monDomV1R1259 ^@ http://purl.uniprot.org/uniprot/F6Z3R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DNMT1 ^@ http://purl.uniprot.org/uniprot/Q8MJ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/13616:ELOVL6 ^@ http://purl.uniprot.org/uniprot/F7DY13 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL6 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that elongates fatty acids with 12, 14 and 16 carbons with higher activity toward C16:0 acyl-CoAs. Catalyzes the synthesis of unsaturated C16 long chain fatty acids and, to a lesser extent, C18:0 and those with low desaturation degree. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||N-Glycosylated. http://togogenome.org/gene/13616:HIBADH ^@ http://purl.uniprot.org/uniprot/A0A5F8G991|||http://purl.uniprot.org/uniprot/F6RV12 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/13616:BTNL9 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9S0|||http://purl.uniprot.org/uniprot/F6TGW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. BTN/MOG family.|||Membrane http://togogenome.org/gene/13616:TUT1 ^@ http://purl.uniprot.org/uniprot/F7EVE8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/13616:LIN28A ^@ http://purl.uniprot.org/uniprot/F6T943 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-28 family.|||nucleolus http://togogenome.org/gene/13616:monDomV1R1205 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NTF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU83|||http://purl.uniprot.org/uniprot/A0A5F8HLM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/13616:WDR46 ^@ http://purl.uniprot.org/uniprot/F6TQX6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/13616:KMT5A ^@ http://purl.uniprot.org/uniprot/A0A5F8GBR1 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/13616:PRKAR2A ^@ http://purl.uniprot.org/uniprot/A0A5F8GKR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PRPF38A ^@ http://purl.uniprot.org/uniprot/F6SUR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/13616:AMD1 ^@ http://purl.uniprot.org/uniprot/F7EKD3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels.|||Heterotetramer of two alpha and two beta chains. http://togogenome.org/gene/13616:HOXA1 ^@ http://purl.uniprot.org/uniprot/F6Y630 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family. Labial subfamily.|||Nucleus http://togogenome.org/gene/13616:PORCN ^@ http://purl.uniprot.org/uniprot/A0A5F8GF81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8D5|||http://purl.uniprot.org/uniprot/F6Y2V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:ALDH3A1 ^@ http://purl.uniprot.org/uniprot/F7BCC7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/13616:CEBPA ^@ http://purl.uniprot.org/uniprot/F7CYK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. C/EBP subfamily.|||Nucleus http://togogenome.org/gene/13616:ABI3 ^@ http://purl.uniprot.org/uniprot/F7GGF8 ^@ Similarity ^@ Belongs to the ABI family. http://togogenome.org/gene/13616:C1H9orf114 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDI0|||http://purl.uniprot.org/uniprot/K7E3J4 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/13616:LOC100013379 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:ZDHHC18 ^@ http://purl.uniprot.org/uniprot/F7C239 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:LOC100016975 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GPRIN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HL94 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/13616:LOC100011666 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEK6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/F7CVX4 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/13616:MCIDAS ^@ http://purl.uniprot.org/uniprot/A0A5F8HJA3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the geminin family.|||Heterodimer (via coiled-coil domain) with GMNN (via coiled-coil domain); targets GMNN to the nucleus. Can form homodimers (in vitro, via coiled-coil domain), but these are much less stable than the heterodimer formed with GMNN.|||Nucleus http://togogenome.org/gene/13616:CBFA2T2 ^@ http://purl.uniprot.org/uniprot/F6Q219 ^@ Similarity ^@ Belongs to the CBFA2T family. http://togogenome.org/gene/13616:TSHB ^@ http://purl.uniprot.org/uniprot/F6V646|||http://purl.uniprot.org/uniprot/Q95J88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Indispensable for the control of thyroid structure and metabolism.|||Secreted http://togogenome.org/gene/13616:SERPINB12 ^@ http://purl.uniprot.org/uniprot/F7DM10 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:PPFIBP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCI6|||http://purl.uniprot.org/uniprot/A0A5F8GK62|||http://purl.uniprot.org/uniprot/A0A5F8HID2 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/13616:HTRA1 ^@ http://purl.uniprot.org/uniprot/F6ZXU8 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/13616:THRA ^@ http://purl.uniprot.org/uniprot/E2FHQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:SCNN1G ^@ http://purl.uniprot.org/uniprot/F6Q7G2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100619141 ^@ http://purl.uniprot.org/uniprot/F7ACA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100027533 ^@ http://purl.uniprot.org/uniprot/F7AIJ8 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/13616:ABI1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMF2|||http://purl.uniprot.org/uniprot/A0A5F8HFS0|||http://purl.uniprot.org/uniprot/A0A5F8HH61|||http://purl.uniprot.org/uniprot/A0A5F8HK55|||http://purl.uniprot.org/uniprot/F7FTR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABI family.|||cytoskeleton|||filopodium|||lamellipodium http://togogenome.org/gene/13616:LOC100020852 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADD1 ^@ http://purl.uniprot.org/uniprot/F6YW76 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/13616:S100A11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the S-100 family.|||Facilitates the differentiation and the cornification of keratinocytes.|||Homodimer; disulfide-linked. http://togogenome.org/gene/13616:SYNGR2 ^@ http://purl.uniprot.org/uniprot/F6SPE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/13616:FAM57A ^@ http://purl.uniprot.org/uniprot/F6TT94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CKB ^@ http://purl.uniprot.org/uniprot/A0A5F8HCG0 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/13616:LOC100025096 ^@ http://purl.uniprot.org/uniprot/F6YKE5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CYRI family.|||Interacts with RAC1 (GTP-bound form preferentially).|||Membrane http://togogenome.org/gene/13616:CASS4 ^@ http://purl.uniprot.org/uniprot/F6XQT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/13616:EVL ^@ http://purl.uniprot.org/uniprot/A0A5F8H137|||http://purl.uniprot.org/uniprot/A0A5F8H882|||http://purl.uniprot.org/uniprot/A0A5F8HAN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ena/VASP family.|||Ena/VASP proteins are actin-associated proteins involved in a range of processes dependent on cytoskeleton remodeling and cell polarity such as axon guidance, lamellipodial and filopodial dynamics, platelet activation and cell migration.|||lamellipodium|||stress fiber http://togogenome.org/gene/13616:TBX6 ^@ http://purl.uniprot.org/uniprot/F7E1E9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:CACNG1 ^@ http://purl.uniprot.org/uniprot/F7CLS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/13616:VN2R510 ^@ http://purl.uniprot.org/uniprot/F7A727 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100016903 ^@ http://purl.uniprot.org/uniprot/F7GEW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KPNB1 ^@ http://purl.uniprot.org/uniprot/F6Q1I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the importin beta family. Importin beta-1 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100620004 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP44|||http://purl.uniprot.org/uniprot/K7E365 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/13616:KDM5B ^@ http://purl.uniprot.org/uniprot/A0A5F8GL11|||http://purl.uniprot.org/uniprot/F6T8F3 ^@ Similarity ^@ Belongs to the JARID1 histone demethylase family. http://togogenome.org/gene/13616:MED23 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSY1|||http://purl.uniprot.org/uniprot/A0A5F8HJ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/13616:LOC100010425 ^@ http://purl.uniprot.org/uniprot/A0A5F8G372 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the resistin/FIZZ family.|||Secreted http://togogenome.org/gene/13616:SLC16A12 ^@ http://purl.uniprot.org/uniprot/F7ADU8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:GTPBP8 ^@ http://purl.uniprot.org/uniprot/A0A5F8H165 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/13616:KIZ ^@ http://purl.uniprot.org/uniprot/A0A5F8HHZ2|||http://purl.uniprot.org/uniprot/F7EI09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kizuna family.|||Centrosomal protein required for establishing a robust mitotic centrosome architecture that can endure the forces that converge on the centrosomes during spindle formation. Required for stabilizing the expanded pericentriolar material around the centriole.|||centrosome|||cilium basal body http://togogenome.org/gene/13616:EIF1AD ^@ http://purl.uniprot.org/uniprot/F7G2D0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EIF1AD family.|||Interacts with GAPDH and STAT1.|||Plays a role into cellular response to oxidative stress. Decreases cell proliferation. http://togogenome.org/gene/13616:ST7L ^@ http://purl.uniprot.org/uniprot/A0A5F8G2J3|||http://purl.uniprot.org/uniprot/A0A5F8G6G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/13616:LOC100016794 ^@ http://purl.uniprot.org/uniprot/F7B8W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:SLC35C2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ITGB8 ^@ http://purl.uniprot.org/uniprot/F7FJ00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/13616:CEBPZ ^@ http://purl.uniprot.org/uniprot/F6ZXT1 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/13616:FSCN3 ^@ http://purl.uniprot.org/uniprot/F7B7H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/13616:GLYR1 ^@ http://purl.uniprot.org/uniprot/F7BSX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIBADH-related family. NP60 subfamily.|||Chromosome http://togogenome.org/gene/13616:OLFM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRH4 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/13616:LOC677869 ^@ http://purl.uniprot.org/uniprot/Q1WK33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C14A family.|||Cytoplasm http://togogenome.org/gene/13616:HARBI1 ^@ http://purl.uniprot.org/uniprot/F6W684 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/13616:LOC100030059 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TRIP10 ^@ http://purl.uniprot.org/uniprot/F7CW65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNBP1 family.|||Cell membrane|||Lysosome|||Membrane|||cell cortex http://togogenome.org/gene/13616:SLA ^@ http://purl.uniprot.org/uniprot/F7CJV5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:LOC100027326 ^@ http://purl.uniprot.org/uniprot/F7BD45 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:LOC100619384 ^@ http://purl.uniprot.org/uniprot/F6QMG1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/13616:GPR135 ^@ http://purl.uniprot.org/uniprot/F7F6Y8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:WBSCR22 ^@ http://purl.uniprot.org/uniprot/F6TDD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100020935 ^@ http://purl.uniprot.org/uniprot/F7E5H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CDH1 ^@ http://purl.uniprot.org/uniprot/F6T0X0 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||E-Cad/CTF2 promotes non-amyloidogenic degradation of Abeta precursors. Has a strong inhibitory effect on APP C99 and C83 production.|||Membrane|||trans-Golgi network http://togogenome.org/gene/13616:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A5F8GIV8|||http://purl.uniprot.org/uniprot/F7GB17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/13616:LOC100022960 ^@ http://purl.uniprot.org/uniprot/F7DRU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:KATNA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8H7 ^@ Activity Regulation|||Caution|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit. Interacts with ASPM; the katanin complex formation KATNA1:KATNB1 is required for the association of ASPM. Interacts with dynein and NDEL1. Associates with the E3 ligase complex containing DYRK2, EDD/UBR5, DDB1 and DCAF1 proteins (EDVP complex). Interacts with KLHL42 (via the kelch domains). Interacts with CUL3; the interaction is enhanced by KLHL42. Interacts with KATNB1 and KATNBL1. Interacts with CAMSAP2 and CAMSAP3; leading to regulate the length of CAMSAP-decorated microtubule stretches.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation. Microtubule release from the mitotic spindle poles may allow depolymerization of the microtubule end proximal to the spindle pole, leading to poleward microtubule flux and poleward motion of chromosome. Microtubule release within the cell body of neurons may be required for their transport into neuronal processes by microtubule-dependent motor proteins. This transport is required for axonal growth.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Midbody|||Phosphorylation by DYRK2 triggers ubiquitination and subsequent degradation.|||The N-terminus is sufficient for interaction with microtubules, although high affinity binding to microtubules also requires an intact C-terminal domain and ATP, which promotes oligomerization.|||Ubiquitinated by the BCR(KLHL42) E3 ubiquitin ligase complex, leading to its proteasomal degradation. Ubiquitinated by the EDVP E3 ligase complex and subsequently targeted for proteasomal degradation.|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/13616:LOC100019050 ^@ http://purl.uniprot.org/uniprot/F7FBW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LAMB1 ^@ http://purl.uniprot.org/uniprot/F7A5M5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||basement membrane http://togogenome.org/gene/13616:LOC100018887 ^@ http://purl.uniprot.org/uniprot/F6PM94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine gamma family.|||Secreted http://togogenome.org/gene/13616:CRYBB2 ^@ http://purl.uniprot.org/uniprot/F7F7L0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/13616:UTP3 ^@ http://purl.uniprot.org/uniprot/F7FNE1 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/13616:FKBP5 ^@ http://purl.uniprot.org/uniprot/F6WS11 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:IL5 ^@ http://purl.uniprot.org/uniprot/F6RSB1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-5 family.|||Homodimer; disulfide-linked.|||Homodimeric cytokine expressed predominantly by T-lymphocytes and NK cells that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Acts also on activated and resting B-cells to induce immunoglobulin production, growth, and differentiation. Mechanistically, exerts its biological effects through a receptor composed of IL5RA subunit and the cytokine receptor common subunit beta/CSF2RB. Binding to the receptor leads to activation of various kinases including LYN, SYK and JAK2 and thereby propagates signals through the RAS-MAPK and JAK-STAT5 pathways respectively.|||Secreted http://togogenome.org/gene/13616:LOC100029170 ^@ http://purl.uniprot.org/uniprot/F6Y592 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:UCMA ^@ http://purl.uniprot.org/uniprot/F6QH33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UCMA family.|||May be involved in the negative control of osteogenic differentiation of osteochondrogenic precursor cells in peripheral zones of fetal cartilage and at the cartilage-bone interface.|||extracellular matrix http://togogenome.org/gene/13616:CSF1R ^@ http://purl.uniprot.org/uniprot/F6WT52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TACC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3I6|||http://purl.uniprot.org/uniprot/F6TDU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/13616:CCR7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H414|||http://purl.uniprot.org/uniprot/F6ZL32 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100020964 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100032606 ^@ http://purl.uniprot.org/uniprot/K7E6D5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/F7BHD3 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/13616:TMEM63A ^@ http://purl.uniprot.org/uniprot/F6WW80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/13616:CHRNA2 ^@ http://purl.uniprot.org/uniprot/F6Z357 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:AP4B1 ^@ http://purl.uniprot.org/uniprot/F6WLR5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/F6UZX8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/13616:COPA ^@ http://purl.uniprot.org/uniprot/F7BJZ7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors. http://togogenome.org/gene/13616:NT5DC4 ^@ http://purl.uniprot.org/uniprot/F6WPC8 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/13616:SLC20A1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIH0|||http://purl.uniprot.org/uniprot/F6VT24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/13616:AKAP8L ^@ http://purl.uniprot.org/uniprot/F7ASB6 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/13616:NTSR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8I3|||http://purl.uniprot.org/uniprot/F7FVU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EFTUD2 ^@ http://purl.uniprot.org/uniprot/F7D3I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Nucleus http://togogenome.org/gene/13616:AGT ^@ http://purl.uniprot.org/uniprot/F6Z008 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/13616:SLC6A5 ^@ http://purl.uniprot.org/uniprot/F7B0M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:NLGN3 ^@ http://purl.uniprot.org/uniprot/D2X2I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CDK19 ^@ http://purl.uniprot.org/uniprot/A0A5F8H986 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:TAF4 ^@ http://purl.uniprot.org/uniprot/F7DMG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/13616:TLX2 ^@ http://purl.uniprot.org/uniprot/F7C2D1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SMIM5 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK56 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100020231 ^@ http://purl.uniprot.org/uniprot/F6ZZ63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/13616:ZC3H12A ^@ http://purl.uniprot.org/uniprot/F7CZ87 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/13616:ADPRH ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Y0|||http://purl.uniprot.org/uniprot/A0A5F8H0D8|||http://purl.uniprot.org/uniprot/A0A5F8H729 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/13616:UCN3 ^@ http://purl.uniprot.org/uniprot/F7BR25 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Binds with high affinity to CRF receptors 2-alpha and 2-beta.|||Secreted|||Suppresses food intake, delays gastric emptying and decreases heat-induced edema. Might represent an endogenous ligand for maintaining homeostasis after stress. http://togogenome.org/gene/13616:TJAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEE0|||http://purl.uniprot.org/uniprot/A0A5F8GMX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TUB ^@ http://purl.uniprot.org/uniprot/A0A5F8H048 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/13616:FAM174A ^@ http://purl.uniprot.org/uniprot/F6SHX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/13616:FICD ^@ http://purl.uniprot.org/uniprot/A0A5F8HEJ7 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/13616:LOC100019653 ^@ http://purl.uniprot.org/uniprot/F7CY11 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:RAD21 ^@ http://purl.uniprot.org/uniprot/F6UVJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/13616:TMEM86A ^@ http://purl.uniprot.org/uniprot/F6ZQU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/13616:CHRDL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHF1|||http://purl.uniprot.org/uniprot/F6RC78 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:LPAR3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:UBN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJI6|||http://purl.uniprot.org/uniprot/A0A5F8H220 ^@ Similarity ^@ Belongs to the ubinuclein family. http://togogenome.org/gene/13616:FHL5 ^@ http://purl.uniprot.org/uniprot/F7DGP2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/13616:NSF ^@ http://purl.uniprot.org/uniprot/F7F4B9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/13616:TBX21 ^@ http://purl.uniprot.org/uniprot/F6PZV9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1I4 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPE ^@ http://purl.uniprot.org/uniprot/F7FDW3 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/13616:PLOD1 ^@ http://purl.uniprot.org/uniprot/F7FVW8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:GUCY1A3 ^@ http://purl.uniprot.org/uniprot/F7BAL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Cytoplasm http://togogenome.org/gene/13616:ALDH6A1 ^@ http://purl.uniprot.org/uniprot/F7EZH4 ^@ Function|||Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA. http://togogenome.org/gene/13616:NUTF2 ^@ http://purl.uniprot.org/uniprot/F7G5K7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/13616:MORF4L1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CREG2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3A7|||http://purl.uniprot.org/uniprot/A0A5F8H8C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREG family.|||Secreted http://togogenome.org/gene/13616:DDAH2 ^@ http://purl.uniprot.org/uniprot/F6UJI5 ^@ Function|||Similarity ^@ Belongs to the DDAH family.|||Hydrolyzes N(G),N(G)-dimethyl-L-arginine (ADMA) and N(G)-monomethyl-L-arginine (MMA) which act as inhibitors of NOS. Has therefore a role in the regulation of nitric oxide generation. http://togogenome.org/gene/13616:LOC100015543 ^@ http://purl.uniprot.org/uniprot/F7CL75 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/13616:KIF2C ^@ http://purl.uniprot.org/uniprot/A0A5F8GGD8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:PPM1L ^@ http://purl.uniprot.org/uniprot/F7ATH3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/13616:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A5F8GW70|||http://purl.uniprot.org/uniprot/A0A5F8HFE4 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/13616:GPATCH1 ^@ http://purl.uniprot.org/uniprot/F6Z6Q3 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/13616:LOC103103471 ^@ http://purl.uniprot.org/uniprot/F6V4Y4 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:CXXC5 ^@ http://purl.uniprot.org/uniprot/F7CW03 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:PRSS12 ^@ http://purl.uniprot.org/uniprot/F7FP84 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100016722 ^@ http://purl.uniprot.org/uniprot/F6ZQ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:APOA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJ22 ^@ Similarity ^@ Belongs to the apolipoprotein A1/A4/E family. http://togogenome.org/gene/13616:ACLY ^@ http://purl.uniprot.org/uniprot/A0A5F8GL12|||http://purl.uniprot.org/uniprot/F6ZC40 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/13616:THYN1 ^@ http://purl.uniprot.org/uniprot/F7D0S8 ^@ Function ^@ Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/13616:ADNP ^@ http://purl.uniprot.org/uniprot/A0A5F8GCK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MAN2B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWC4 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/13616:VPS36 ^@ http://purl.uniprot.org/uniprot/F7A6S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/13616:LOC100027020 ^@ http://purl.uniprot.org/uniprot/F7EV24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:PPEF1 ^@ http://purl.uniprot.org/uniprot/F6TMU4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/13616:IGF1 ^@ http://purl.uniprot.org/uniprot/F6Y770 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/13616:LOC100027269 ^@ http://purl.uniprot.org/uniprot/F7GI24 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/13616:RHBDL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GK43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/13616:B3GNT5 ^@ http://purl.uniprot.org/uniprot/F7CQU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:EPHB6 ^@ http://purl.uniprot.org/uniprot/F7ES42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CENPC ^@ http://purl.uniprot.org/uniprot/F7AN85 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/13616:BOLA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G267 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/13616:BCL2L1 ^@ http://purl.uniprot.org/uniprot/F6WA14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane|||Mitochondrion matrix|||Nucleus membrane|||centrosome|||cytosol|||synaptic vesicle membrane http://togogenome.org/gene/13616:LTV1 ^@ http://purl.uniprot.org/uniprot/F6TK41 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/13616:NR2C1 ^@ http://purl.uniprot.org/uniprot/F6Z852 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:SDAD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/13616:IMPA1 ^@ http://purl.uniprot.org/uniprot/K7E4M7 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/13616:NPY1R ^@ http://purl.uniprot.org/uniprot/F6YEY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MCM4 ^@ http://purl.uniprot.org/uniprot/F6SAE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/13616:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUW9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:PNN ^@ http://purl.uniprot.org/uniprot/F7DZE3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pinin family.|||Found in a mRNA splicing-dependent exon junction complex (EJC). Found in a complex with SR proteins. Found in a mRNP complex with RNPS1. Component of the PSAP complex consisting of RNPS1, SAP18 and PNN. Interacts with PNISR, CTBP1, CTBP2, KRT8, KRT18, KRT19, PS1D/PNO40, PPIG, RNPS1, SFRS4 and SRRM2. Identified in the spliceosome C complex.|||Nucleus speckle|||desmosome http://togogenome.org/gene/13616:ARCN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HL90|||http://purl.uniprot.org/uniprot/F7GIN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/13616:MCM3 ^@ http://purl.uniprot.org/uniprot/F6YYR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/13616:PTPN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0Y7|||http://purl.uniprot.org/uniprot/F7B2D9 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 1 subfamily. http://togogenome.org/gene/13616:PHLDA3 ^@ http://purl.uniprot.org/uniprot/F7EBX2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:SLC39A3 ^@ http://purl.uniprot.org/uniprot/F7CKN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SPON2 ^@ http://purl.uniprot.org/uniprot/F6SVP6 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/13616:SLC7A13 ^@ http://purl.uniprot.org/uniprot/F7AJ24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CEP44 ^@ http://purl.uniprot.org/uniprot/F7C6L8 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/13616:VTI1B ^@ http://purl.uniprot.org/uniprot/F6USP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/13616:FBLN7 ^@ http://purl.uniprot.org/uniprot/F7GEP7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:TMEM19 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/13616:XKR9 ^@ http://purl.uniprot.org/uniprot/F6XQ40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XK family.|||Membrane http://togogenome.org/gene/13616:PHYHIP ^@ http://purl.uniprot.org/uniprot/F7F9L7 ^@ Similarity ^@ Belongs to the PHYHIP family. http://togogenome.org/gene/13616:LOC100015788 ^@ http://purl.uniprot.org/uniprot/F6X635 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:EIF4E3 ^@ http://purl.uniprot.org/uniprot/F7D857 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/13616:CTSS ^@ http://purl.uniprot.org/uniprot/F6Z032 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Lysosome http://togogenome.org/gene/13616:PEX16 ^@ http://purl.uniprot.org/uniprot/F6W6D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/13616:GRPEL2 ^@ http://purl.uniprot.org/uniprot/F6XY80 ^@ Similarity ^@ Belongs to the GrpE family. http://togogenome.org/gene/13616:GABRA6 ^@ http://purl.uniprot.org/uniprot/F7AWR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:RPL7A ^@ http://purl.uniprot.org/uniprot/F6SJL4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/13616:BLCAP ^@ http://purl.uniprot.org/uniprot/F7EWW2 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/13616:ULBP-LIKE ^@ http://purl.uniprot.org/uniprot/D7URV6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:TMC3 ^@ http://purl.uniprot.org/uniprot/F6WCE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/13616:TRIM54 ^@ http://purl.uniprot.org/uniprot/F7E1B1 ^@ Function|||Subcellular Location Annotation ^@ May bind and stabilize microtubules during myotubes formation.|||Z line http://togogenome.org/gene/13616:C8G ^@ http://purl.uniprot.org/uniprot/F6XCK8 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:ARL1 ^@ http://purl.uniprot.org/uniprot/F6PNX7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:HECTD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G9H7|||http://purl.uniprot.org/uniprot/F7B4N3 ^@ Function|||Similarity ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates. http://togogenome.org/gene/13616:PRKAR2B ^@ http://purl.uniprot.org/uniprot/F7ER73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CYPIIF2 ^@ http://purl.uniprot.org/uniprot/F7D5B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:ITGAV ^@ http://purl.uniprot.org/uniprot/F7D459 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:DPP7 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1Q0 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/13616:FGF3 ^@ http://purl.uniprot.org/uniprot/K7E687 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:monDomV1R1266 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ADSS ^@ http://purl.uniprot.org/uniprot/A0A5F8G4H9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Mitochondrion|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/13616:CNN3 ^@ http://purl.uniprot.org/uniprot/F6X6V5 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/13616:TOP2A ^@ http://purl.uniprot.org/uniprot/F7ABY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:DRAM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100031238 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5B2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100618683 ^@ http://purl.uniprot.org/uniprot/F7A6Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:HMGA1 ^@ http://purl.uniprot.org/uniprot/F6SBW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/13616:TRIM67 ^@ http://purl.uniprot.org/uniprot/F7GAM9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:DCT ^@ http://purl.uniprot.org/uniprot/F7CPD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane http://togogenome.org/gene/13616:MODO-UM ^@ http://purl.uniprot.org/uniprot/C6ZIV8 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:LOC100011021 ^@ http://purl.uniprot.org/uniprot/F6ZEA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/13616:FSHR ^@ http://purl.uniprot.org/uniprot/A0A5F8HFT2|||http://purl.uniprot.org/uniprot/F7CIX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/13616:FGD5 ^@ http://purl.uniprot.org/uniprot/F6RZS2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:AGTR1 ^@ http://purl.uniprot.org/uniprot/F7GKI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/13616:SLC6A18 ^@ http://purl.uniprot.org/uniprot/F6ZGL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/13616:NEK6 ^@ http://purl.uniprot.org/uniprot/F6WNU9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:SIKE1 ^@ http://purl.uniprot.org/uniprot/F6TQ91 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/13616:PRTFDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/13616:EFEMP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD15|||http://purl.uniprot.org/uniprot/F6RHE2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ZRANB2 ^@ http://purl.uniprot.org/uniprot/F6Y669 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus|||Splice factor required for alternative splicing of TRA2B/SFRS10 transcripts. May interfere with constitutive 5'-splice site selection. http://togogenome.org/gene/13616:MKX ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Y6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ARRDC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4Y1 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/13616:ISCA1 ^@ http://purl.uniprot.org/uniprot/F7GBC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/13616:CASC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3U3|||http://purl.uniprot.org/uniprot/A0A5F8GBQ8|||http://purl.uniprot.org/uniprot/A0A5F8GLC5|||http://purl.uniprot.org/uniprot/A0A5F8H560|||http://purl.uniprot.org/uniprot/A0A5F8H5R7|||http://purl.uniprot.org/uniprot/F6Z566 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/13616:PTAFR ^@ http://purl.uniprot.org/uniprot/F7G9B8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/13616:POLR3A ^@ http://purl.uniprot.org/uniprot/F6ZEZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/13616:ITGA11 ^@ http://purl.uniprot.org/uniprot/F7C5G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/13616:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6A2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Functions as a key regulator of cell membrane composition by regulating proteins surface expression. Also, plays a role in regulation of processes including cell migration, cell proliferation, cell contraction and cell adhesion.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/13616:GATA2 ^@ http://purl.uniprot.org/uniprot/F6ZA02 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CCNJ ^@ http://purl.uniprot.org/uniprot/F6TN79 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/13616:MCM6 ^@ http://purl.uniprot.org/uniprot/F7ES17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/13616:CDC14A ^@ http://purl.uniprot.org/uniprot/A0A5F8GGN3|||http://purl.uniprot.org/uniprot/A0A5F8GM33 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/13616:LOC100023783 ^@ http://purl.uniprot.org/uniprot/F7A9K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/13616:CAB39L ^@ http://purl.uniprot.org/uniprot/F7BCN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/13616:YARS2 ^@ http://purl.uniprot.org/uniprot/F7GCD4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:CAMK1D ^@ http://purl.uniprot.org/uniprot/F6R272 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:HTR2A ^@ http://purl.uniprot.org/uniprot/F6WZZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/13616:RPS15A ^@ http://purl.uniprot.org/uniprot/F6WX66 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/13616:RAB9B ^@ http://purl.uniprot.org/uniprot/F6QXW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||phagosome membrane http://togogenome.org/gene/13616:FGFR2 ^@ http://purl.uniprot.org/uniprot/F7DHF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DDIT4L ^@ http://purl.uniprot.org/uniprot/F7DKS7 ^@ Similarity ^@ Belongs to the DDIT4 family. http://togogenome.org/gene/13616:GPR158 ^@ http://purl.uniprot.org/uniprot/F6PWH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SH3RF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HD34|||http://purl.uniprot.org/uniprot/F6W659 ^@ Similarity ^@ Belongs to the SH3RF family. http://togogenome.org/gene/13616:monDomV1R1242 ^@ http://purl.uniprot.org/uniprot/F7GLE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DLK1 ^@ http://purl.uniprot.org/uniprot/F6ZLP4|||http://purl.uniprot.org/uniprot/Q2HJK6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:DCP1B ^@ http://purl.uniprot.org/uniprot/A0A5F8HEF4 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/13616:LOC100027544 ^@ http://purl.uniprot.org/uniprot/F6XE08 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/13616:TRAF5 ^@ http://purl.uniprot.org/uniprot/F6Z7K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/13616:AP1B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2B4|||http://purl.uniprot.org/uniprot/A0A5F8GNZ3|||http://purl.uniprot.org/uniprot/A0A5F8GVN0|||http://purl.uniprot.org/uniprot/F7CUA3 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:PSMA6 ^@ http://purl.uniprot.org/uniprot/F7DYR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:ZER1 ^@ http://purl.uniprot.org/uniprot/F7EZJ5 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/13616:LOC100031012 ^@ http://purl.uniprot.org/uniprot/F6QJ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Very large inducible GTPase (VLIG) family.|||Nucleus http://togogenome.org/gene/13616:LOC103097665 ^@ http://purl.uniprot.org/uniprot/K7E2D4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103098204 ^@ http://purl.uniprot.org/uniprot/F6Z545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/13616:DGAT1 ^@ http://purl.uniprot.org/uniprot/F7C164 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Homodimer or homotetramer; both forms have similar enzymatic activities.|||Membrane http://togogenome.org/gene/13616:PEAR1 ^@ http://purl.uniprot.org/uniprot/F7DLS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:HLX ^@ http://purl.uniprot.org/uniprot/F6U7F3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:EIF1B ^@ http://purl.uniprot.org/uniprot/F7DF53 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/13616:SMOC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G1V5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:MEGF9 ^@ http://purl.uniprot.org/uniprot/F6XPU1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ANXA4 ^@ http://purl.uniprot.org/uniprot/F7GDF3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/13616:LOC100026143 ^@ http://purl.uniprot.org/uniprot/F7D5A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DMAP1 ^@ http://purl.uniprot.org/uniprot/F7CXW9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100025406 ^@ http://purl.uniprot.org/uniprot/K7E0E6 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/13616:LOC100010666 ^@ http://purl.uniprot.org/uniprot/A0A5F8G700 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100030810 ^@ http://purl.uniprot.org/uniprot/F6Y3Y9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SMARCA4 ^@ http://purl.uniprot.org/uniprot/F7CAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/13616:CDIP1 ^@ http://purl.uniprot.org/uniprot/F7GEU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1209 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NLRP12 ^@ http://purl.uniprot.org/uniprot/F6PZU3 ^@ Similarity ^@ Belongs to the NLRP family. http://togogenome.org/gene/13616:MOCS1 ^@ http://purl.uniprot.org/uniprot/F7BN00 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/13616:LOC100028946 ^@ http://purl.uniprot.org/uniprot/F7AXI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RBM8A ^@ http://purl.uniprot.org/uniprot/A0A5F8HHR3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RBM8A family.|||Core component of the splicing-dependent multiprotein exon junction complex (EJC) deposited at splice junctions on mRNAs.|||Cytoplasm|||Heterodimer with MAGOH. Part of the mRNA splicing-dependent exon junction complex (EJC) complex; the core complex contains CASC3, EIF4A3, MAGOH and RBM8A.|||Nucleus|||Nucleus speckle http://togogenome.org/gene/13616:PAPSS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G3N5|||http://purl.uniprot.org/uniprot/F6WHV8 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/13616:LOC100021477 ^@ http://purl.uniprot.org/uniprot/F6PNL3 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/13616:HSPA12A ^@ http://purl.uniprot.org/uniprot/A0A5F8GJ38 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:XPC ^@ http://purl.uniprot.org/uniprot/F7FCG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPC family.|||Nucleus http://togogenome.org/gene/13616:GPR37 ^@ http://purl.uniprot.org/uniprot/F6XYC7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:AASDHPPT ^@ http://purl.uniprot.org/uniprot/F6ZCR9 ^@ Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family. http://togogenome.org/gene/13616:C2H3orf70 ^@ http://purl.uniprot.org/uniprot/F7DI48 ^@ Similarity ^@ Belongs to the UPF0524 family. http://togogenome.org/gene/13616:SEC61G ^@ http://purl.uniprot.org/uniprot/A0A5F8GZB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:TPPP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G683 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/13616:DARS ^@ http://purl.uniprot.org/uniprot/F6YRH4 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/13616:PEX19 ^@ http://purl.uniprot.org/uniprot/F7AX56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-19 family.|||Interacts with a broad range of peroxisomal membrane proteins, including PEX3, PEX10, PEX11A, PEX11B, PEX12, PEX13, PEX14 and PEX16, PXMP2/PMP22, PXMP4/PMP24, SLC25A17/PMP34, ABCD1/ALDP, ABCD2/ALDRP, and ABCD3/PMP70. Also interacts with the tumor suppressor CDKN2A/p19ARF.|||Necessary for early peroxisomal biogenesis. Acts both as a cytosolic chaperone and as an import receptor for peroxisomal membrane proteins (PMPs). Binds and stabilizes newly synthesized PMPs in the cytoplasm by interacting with their hydrophobic membrane-spanning domains, and targets them to the peroxisome membrane by binding to the integral membrane protein PEX3. Excludes CDKN2A from the nucleus and prevents its interaction with MDM2, which results in active degradation of TP53.|||Peroxisome membrane http://togogenome.org/gene/13616:HOXA13 ^@ http://purl.uniprot.org/uniprot/F6USK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:DGCR14 ^@ http://purl.uniprot.org/uniprot/F6Y536 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/13616:NF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1A1|||http://purl.uniprot.org/uniprot/F7GLA2 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/13616:TAS2R1 ^@ http://purl.uniprot.org/uniprot/Q2ABA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:FAM83A ^@ http://purl.uniprot.org/uniprot/F6QBX8 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/13616:monDomV1R1206 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DNASE1 ^@ http://purl.uniprot.org/uniprot/F6Q7C3|||http://purl.uniprot.org/uniprot/F7E8P4 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/13616:KXD1 ^@ http://purl.uniprot.org/uniprot/F7CSK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Lysosome membrane http://togogenome.org/gene/13616:PES1 ^@ http://purl.uniprot.org/uniprot/F6QKJ3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Chromosome|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome. Interacts with IRS1 and UBTF. May interact with MAP1B.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||Sumoylated.|||nucleolus|||nucleoplasm http://togogenome.org/gene/13616:ATP5E ^@ http://purl.uniprot.org/uniprot/F6ZCW3 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ATPase epsilon family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits. http://togogenome.org/gene/13616:LGR6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6J6|||http://purl.uniprot.org/uniprot/A0A5F8HJT6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:MARVELD2 ^@ http://purl.uniprot.org/uniprot/F6SYH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELL/occludin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:NETO2 ^@ http://purl.uniprot.org/uniprot/F7C941 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100012130 ^@ http://purl.uniprot.org/uniprot/F7BYL6 ^@ Subcellular Location Annotation ^@ Lysosome http://togogenome.org/gene/13616:T2R25 ^@ http://purl.uniprot.org/uniprot/Q2AB94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:FOS ^@ http://purl.uniprot.org/uniprot/F6WX28 ^@ Similarity ^@ Belongs to the bZIP family. Fos subfamily. http://togogenome.org/gene/13616:PMPCB ^@ http://purl.uniprot.org/uniprot/F6WXQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Heterodimer of PMPCA (alpha) and PMPCB (beta) subunits, forming the mitochondrial processing protease (MPP) in which PMPCA is involved in substrate recognition and binding and PMPCB is the catalytic subunit.|||Mitochondrion matrix http://togogenome.org/gene/13616:NDFIP1 ^@ http://purl.uniprot.org/uniprot/F7AV91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100013686 ^@ http://purl.uniprot.org/uniprot/F7ER43 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:RMI1 ^@ http://purl.uniprot.org/uniprot/F7FCW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RMI1 family.|||Essential component of the RMI complex, a complex that plays an important role in the processing of homologous recombination intermediates to limit DNA crossover formation in cells. Promotes TOP3A binding to double Holliday junctions (DHJ) and hence stimulates TOP3A-mediated dissolution. Required for BLM phosphorylation during mitosis. Within the BLM complex, required for BLM and TOP3A stability.|||Nucleus http://togogenome.org/gene/13616:YIPF6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZR7|||http://purl.uniprot.org/uniprot/F7GDZ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100024443 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FAM206A ^@ http://purl.uniprot.org/uniprot/F6PLE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABITRAM family.|||growth cone|||lamellipodium http://togogenome.org/gene/13616:LOC100017914 ^@ http://purl.uniprot.org/uniprot/F6U2X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CDKN2AIP ^@ http://purl.uniprot.org/uniprot/F6Y989 ^@ Similarity ^@ Belongs to the CARF family. http://togogenome.org/gene/13616:CENPH ^@ http://purl.uniprot.org/uniprot/F6QC79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/13616:DHX8 ^@ http://purl.uniprot.org/uniprot/F7BWD9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100010924 ^@ http://purl.uniprot.org/uniprot/F6PQ73 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:RAMP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2K0 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/13616:VOPP1 ^@ http://purl.uniprot.org/uniprot/K7E261 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Increases the transcriptional activity of NFKB1 by facilitating its nuclear translocation, DNA-binding and associated apoptotic response, when overexpressed.|||Membrane http://togogenome.org/gene/13616:INHA ^@ http://purl.uniprot.org/uniprot/A0A5F8GV02 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Secreted http://togogenome.org/gene/13616:PSMA4 ^@ http://purl.uniprot.org/uniprot/F7FST5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:SMIM19 ^@ http://purl.uniprot.org/uniprot/F6WNJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM19 family.|||Membrane http://togogenome.org/gene/13616:OCRL ^@ http://purl.uniprot.org/uniprot/A0A5F8GD36|||http://purl.uniprot.org/uniprot/F6PHM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/13616:DRAXIN ^@ http://purl.uniprot.org/uniprot/F7A1L5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord. Inhibits the stabilization of cytosolic beta-catenin (CTNNB1) via its interaction with LRP6, thereby acting as an antagonist of Wnt signaling pathway.|||Interacts with LRP6.|||Secreted http://togogenome.org/gene/13616:CTNNA1 ^@ http://purl.uniprot.org/uniprot/F7ALE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||cytoskeleton http://togogenome.org/gene/13616:FAM46B ^@ http://purl.uniprot.org/uniprot/F7BGH7 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/13616:VIPR1 ^@ http://purl.uniprot.org/uniprot/F7BIH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FMO5 ^@ http://purl.uniprot.org/uniprot/F7FCD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as Baeyer-Villiger monooxygenase on a broad range of substrates. Catalyzes the insertion of an oxygen atom into a carbon-carbon bond adjacent to a carbonyl, which converts ketones to esters.|||Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/13616:PPP2R5C ^@ http://purl.uniprot.org/uniprot/F7D9Z3 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/13616:LMNB2 ^@ http://purl.uniprot.org/uniprot/F6UM44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||Nucleus lamina http://togogenome.org/gene/13616:ARHGEF12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GN29|||http://purl.uniprot.org/uniprot/F7B035 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane http://togogenome.org/gene/13616:ABCG8 ^@ http://purl.uniprot.org/uniprot/F7EEI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/13616:IMPACT ^@ http://purl.uniprot.org/uniprot/F7G2M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/13616:LOC100030264 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6M5|||http://purl.uniprot.org/uniprot/A0A5F8GPZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LOC100616680 ^@ http://purl.uniprot.org/uniprot/F7C289 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PARD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Q7|||http://purl.uniprot.org/uniprot/A0A5F8GG83|||http://purl.uniprot.org/uniprot/A0A5F8GPI3|||http://purl.uniprot.org/uniprot/A0A5F8GU07|||http://purl.uniprot.org/uniprot/A0A5F8GV23|||http://purl.uniprot.org/uniprot/A0A5F8H9F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAR3 family.|||Cell junction|||Endomembrane system http://togogenome.org/gene/13616:VN2R530 ^@ http://purl.uniprot.org/uniprot/F6PSJ4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100012586 ^@ http://purl.uniprot.org/uniprot/F7G767 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TCEA3 ^@ http://purl.uniprot.org/uniprot/F7D7C9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SEPT8 ^@ http://purl.uniprot.org/uniprot/F6VBN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Filament-forming cytoskeletal GTPase.|||Presynapse|||Septins polymerize into heterooligomeric protein complexes that form filaments.|||synaptic vesicle membrane http://togogenome.org/gene/13616:ORAI3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/13616:NARFL ^@ http://purl.uniprot.org/uniprot/F7FVH9 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/13616:IFT46 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT46 family.|||cilium|||cilium basal body http://togogenome.org/gene/13616:IWS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWV7|||http://purl.uniprot.org/uniprot/F7AEQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ICAM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. ICAM family.|||Membrane http://togogenome.org/gene/13616:LLPH ^@ http://purl.uniprot.org/uniprot/K7E6A7 ^@ Similarity ^@ Belongs to the learning-associated protein family. http://togogenome.org/gene/13616:CCDC90B ^@ http://purl.uniprot.org/uniprot/F6R6U9 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/13616:SH3BP5L ^@ http://purl.uniprot.org/uniprot/F7B0V3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/13616:TSNAX ^@ http://purl.uniprot.org/uniprot/A0A5F8GGL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/13616:monDomV1R1282 ^@ http://purl.uniprot.org/uniprot/F7B7R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TXLNA ^@ http://purl.uniprot.org/uniprot/F7FEQ0 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/13616:FXN ^@ http://purl.uniprot.org/uniprot/F6PJV5 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/13616:LOC100032988 ^@ http://purl.uniprot.org/uniprot/F6PNF4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/13616:MFF ^@ http://purl.uniprot.org/uniprot/A0A5F8GLY2|||http://purl.uniprot.org/uniprot/A0A5F8GM42|||http://purl.uniprot.org/uniprot/A0A5F8GTC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. May be involved in regulation of synaptic vesicle membrane dynamics by recruitment of DNM1L to clathrin-containing vesicles. http://togogenome.org/gene/13616:CHI3L1 ^@ http://purl.uniprot.org/uniprot/F6YQY7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 18 family.|||Cytoplasm|||Endoplasmic reticulum|||Monomer.|||extracellular space http://togogenome.org/gene/13616:EXT1 ^@ http://purl.uniprot.org/uniprot/F6VVP6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane|||Forms a homo/heterooligomeric complex with EXT2. Interacts with NDST1.|||cis-Golgi network membrane http://togogenome.org/gene/13616:ACTB ^@ http://purl.uniprot.org/uniprot/F7DIB7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:CLDN19 ^@ http://purl.uniprot.org/uniprot/F6QD11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:GPR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DENND6A ^@ http://purl.uniprot.org/uniprot/F6TF37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Endosome|||Recycling endosome http://togogenome.org/gene/13616:TBP ^@ http://purl.uniprot.org/uniprot/F7CFV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/13616:CHMP3 ^@ http://purl.uniprot.org/uniprot/F7FNS4 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/13616:CASC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5M3|||http://purl.uniprot.org/uniprot/F7FHF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/13616:STON1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/13616:LOC103102723 ^@ http://purl.uniprot.org/uniprot/F6Z9J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Endoplasmic reticulum http://togogenome.org/gene/13616:ENTPD2 ^@ http://purl.uniprot.org/uniprot/F6TJZ5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:MRPL4 ^@ http://purl.uniprot.org/uniprot/F7CG27 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/13616:GPR107 ^@ http://purl.uniprot.org/uniprot/F6UFL2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPL8 ^@ http://purl.uniprot.org/uniprot/F6TDX6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/13616:PRNP ^@ http://purl.uniprot.org/uniprot/F6QBG5|||http://purl.uniprot.org/uniprot/I7KJS6 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prion family.|||Cell membrane|||Golgi apparatus|||Membrane|||The sequence shown here is derived from an EMBL/GenBank/DDBJ third party annotation (TPA) entry. http://togogenome.org/gene/13616:VN2R610 ^@ http://purl.uniprot.org/uniprot/F6VJW2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100031958 ^@ http://purl.uniprot.org/uniprot/F6YEH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/13616:CD34 ^@ http://purl.uniprot.org/uniprot/F6TIF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RRS1 ^@ http://purl.uniprot.org/uniprot/F6UTP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/13616:LYPD6 ^@ http://purl.uniprot.org/uniprot/F7GBF3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100030139 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:DUSP7 ^@ http://purl.uniprot.org/uniprot/F7DFP1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:RAB18 ^@ http://purl.uniprot.org/uniprot/F6ZX76 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/13616:LOC100015635 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT50 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:RECQL5 ^@ http://purl.uniprot.org/uniprot/F7GB60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/13616:WDR83OS ^@ http://purl.uniprot.org/uniprot/A0A5F8GXI5 ^@ Similarity ^@ Belongs to the Asterix family. http://togogenome.org/gene/13616:LOC100014611 ^@ http://purl.uniprot.org/uniprot/F7G7A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/13616:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLI8|||http://purl.uniprot.org/uniprot/A0A5F8H5R6|||http://purl.uniprot.org/uniprot/F7GGS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/13616:ADRA1A ^@ http://purl.uniprot.org/uniprot/F7E6P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/13616:FAM83D ^@ http://purl.uniprot.org/uniprot/F6US57 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/13616:ZIC5 ^@ http://purl.uniprot.org/uniprot/F6W721 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/13616:LOC103093588 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQM9|||http://purl.uniprot.org/uniprot/K7E2G0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RAB33A ^@ http://purl.uniprot.org/uniprot/F7D9I2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/13616:LOC100027547 ^@ http://purl.uniprot.org/uniprot/F7B9C2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:GALC ^@ http://purl.uniprot.org/uniprot/A0A5F8GXE9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/13616:POMT1 ^@ http://purl.uniprot.org/uniprot/F6PJ87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/13616:DNASE2B ^@ http://purl.uniprot.org/uniprot/F6Y5N6 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/13616:TAAR1 ^@ http://purl.uniprot.org/uniprot/F6RSM4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CHST10 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:HACD2 ^@ http://purl.uniprot.org/uniprot/F6PRX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:IST1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/13616:T2R3J ^@ http://purl.uniprot.org/uniprot/Q2ABA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:TTC36 ^@ http://purl.uniprot.org/uniprot/F7G9C7 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/13616:LOC100026593 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKM5 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/13616:LOC100010080 ^@ http://purl.uniprot.org/uniprot/F6PJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100011114 ^@ http://purl.uniprot.org/uniprot/F7A2F0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/13616:GDAP1L1 ^@ http://purl.uniprot.org/uniprot/F7FM02 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/13616:TRMO ^@ http://purl.uniprot.org/uniprot/F6TYQ5 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/13616:CD180 ^@ http://purl.uniprot.org/uniprot/F6TTU8 ^@ Similarity ^@ Belongs to the Toll-like receptor family. http://togogenome.org/gene/13616:DNAJC16 ^@ http://purl.uniprot.org/uniprot/F7G145 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100015061 ^@ http://purl.uniprot.org/uniprot/F7AAP1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:F11R ^@ http://purl.uniprot.org/uniprot/A0A5F8GDW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:HGH1 ^@ http://purl.uniprot.org/uniprot/F7DQL3 ^@ Similarity ^@ Belongs to the HGH1 family. http://togogenome.org/gene/13616:ARSB ^@ http://purl.uniprot.org/uniprot/F6X4S3 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:KCNA10 ^@ http://purl.uniprot.org/uniprot/F6UCT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:FNTB ^@ http://purl.uniprot.org/uniprot/F6YB33 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Essential subunit of the farnesyltransferase complex. Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins having the C-terminal sequence Cys-aliphatic-aliphatic-X.|||Heterodimer of FNTA and FNTB. http://togogenome.org/gene/13616:LGALS3 ^@ http://purl.uniprot.org/uniprot/F7FSR7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/13616:LOC100020127 ^@ http://purl.uniprot.org/uniprot/F7AZ53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:CHST4 ^@ http://purl.uniprot.org/uniprot/F7EX04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/13616:FGF4 ^@ http://purl.uniprot.org/uniprot/F6VES9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Secreted http://togogenome.org/gene/13616:MAGOH ^@ http://purl.uniprot.org/uniprot/F6URP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/13616:SRP54 ^@ http://purl.uniprot.org/uniprot/F7GC32 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Nucleus speckle http://togogenome.org/gene/13616:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H338|||http://purl.uniprot.org/uniprot/F6RDG8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/13616:VPS25 ^@ http://purl.uniprot.org/uniprot/F7FUU3 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/13616:TCF25 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2L2 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/13616:PLCZ1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8Z9 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.|||perinuclear region http://togogenome.org/gene/13616:NAV2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G455|||http://purl.uniprot.org/uniprot/A0A5F8GKU8|||http://purl.uniprot.org/uniprot/A0A5F8GNI9|||http://purl.uniprot.org/uniprot/F6ZVI0 ^@ Similarity ^@ Belongs to the Nav/unc-53 family. http://togogenome.org/gene/13616:GDF5 ^@ http://purl.uniprot.org/uniprot/F6WIE9 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:CHURC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCP8 ^@ Similarity ^@ Belongs to the Churchill family. http://togogenome.org/gene/13616:LOC100019462 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TTC30/dfy-1/fleer family.|||Required for polyglutamylation of axonemal tubulin. Plays a role in anterograde intraflagellar transport (IFT), the process by which cilia precursors are transported from the base of the cilium to the site of their incorporation at the tip.|||cilium http://togogenome.org/gene/13616:GDPGP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDPGP1 family.|||Cytoplasm|||Specific and highly efficient GDP-D-glucose phosphorylase regulating the levels of GDP-D-glucose in cells. http://togogenome.org/gene/13616:KIAA1161 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDR7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/13616:TACR1 ^@ http://purl.uniprot.org/uniprot/F6X011 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/13616:ACAT1 ^@ http://purl.uniprot.org/uniprot/F7EQ19 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/13616:RWDD3 ^@ http://purl.uniprot.org/uniprot/F6TEP4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TLR8 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/13616:MPP5 ^@ http://purl.uniprot.org/uniprot/F6VCY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Endomembrane system|||tight junction http://togogenome.org/gene/13616:TMED7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:NAIF1 ^@ http://purl.uniprot.org/uniprot/F6UKT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAIF1 family.|||Induces apoptosis.|||Nucleus http://togogenome.org/gene/13616:GNB4 ^@ http://purl.uniprot.org/uniprot/F7G3J2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/13616:SLC39A10 ^@ http://purl.uniprot.org/uniprot/F7ALF5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100021456 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:TRAP1 ^@ http://purl.uniprot.org/uniprot/F7E8R0 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/13616:APLNR ^@ http://purl.uniprot.org/uniprot/A0A5F8GZ79 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:AGRP ^@ http://purl.uniprot.org/uniprot/F6XD58 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100025667 ^@ http://purl.uniprot.org/uniprot/K7E258 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:LOC100013145 ^@ http://purl.uniprot.org/uniprot/K7E526 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the kappa-casein family.|||Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk.|||Secreted http://togogenome.org/gene/13616:FAM46D ^@ http://purl.uniprot.org/uniprot/F7AS71 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/13616:PTP4A3 ^@ http://purl.uniprot.org/uniprot/F6SUC7 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/13616:N6AMT1 ^@ http://purl.uniprot.org/uniprot/F6RJZ3 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/13616:NEK7 ^@ http://purl.uniprot.org/uniprot/F7EFY6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:LOC100014116 ^@ http://purl.uniprot.org/uniprot/F7C2Q6 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/13616:FDFT1 ^@ http://purl.uniprot.org/uniprot/F7FMA5 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/13616:ZC3H12D ^@ http://purl.uniprot.org/uniprot/A0A5F8H4G0 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/13616:ZKSCAN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY83|||http://purl.uniprot.org/uniprot/F6S3Z6 ^@ Function ^@ May be involved in transcriptional regulation. http://togogenome.org/gene/13616:CCDC39 ^@ http://purl.uniprot.org/uniprot/A0A5F8GP59|||http://purl.uniprot.org/uniprot/F7G3V1 ^@ Similarity ^@ Belongs to the CCDC39 family. http://togogenome.org/gene/13616:PTPN14 ^@ http://purl.uniprot.org/uniprot/F6SJ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/13616:PTGS2 ^@ http://purl.uniprot.org/uniprot/F7FSX5 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Endoplasmic reticulum membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Microsome membrane|||Nucleus inner membrane|||Nucleus outer membrane http://togogenome.org/gene/13616:UCP2 ^@ http://purl.uniprot.org/uniprot/F6YX95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:KMO ^@ http://purl.uniprot.org/uniprot/F6Q9U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid, a neurotoxic NMDA receptor antagonist and potential endogenous inhibitor of NMDA receptor signaling in axonal targeting, synaptogenesis and apoptosis during brain development. Quinolinic acid may also affect NMDA receptor signaling in pancreatic beta cells, osteoblasts, myocardial cells, and the gastrointestinal tract.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:TRIM3 ^@ http://purl.uniprot.org/uniprot/F7FDA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIM/RBCC family.|||Cytoplasm http://togogenome.org/gene/13616:ADPRHL2 ^@ http://purl.uniprot.org/uniprot/F6YHQ9 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/13616:CAPN2 ^@ http://purl.uniprot.org/uniprot/F6ZEJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/13616:SEMA3F ^@ http://purl.uniprot.org/uniprot/A0A5F8GNM3|||http://purl.uniprot.org/uniprot/F6YFV8 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:OCEL1 ^@ http://purl.uniprot.org/uniprot/F7G5C5 ^@ Similarity ^@ Belongs to the ELL/occludin family. http://togogenome.org/gene/13616:T2R27 ^@ http://purl.uniprot.org/uniprot/Q2AB92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:OSGEP ^@ http://purl.uniprot.org/uniprot/F6RZ40 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least TP53RK, TPRKB, OSGEP and LAGE3; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. OSGEP likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100020928 ^@ http://purl.uniprot.org/uniprot/K7E218 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:IL16 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCE1|||http://purl.uniprot.org/uniprot/F6WC84 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/13616:LOC100619502 ^@ http://purl.uniprot.org/uniprot/F7B8I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/13616:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:CDC42EP1 ^@ http://purl.uniprot.org/uniprot/F6XMH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/13616:STX16 ^@ http://purl.uniprot.org/uniprot/A0A5F8GD93|||http://purl.uniprot.org/uniprot/A0A5F8H2H0 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/13616:IHH ^@ http://purl.uniprot.org/uniprot/F6XEQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the hedgehog family.|||Cell membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Multimer.|||Secreted|||The C-terminal part of the hedgehog protein precursor displays an autoproteolysis activity that results in the cleavage of the full-length protein into two parts (N-product and C-product). In addition, the C-terminal part displays a cholesterol transferase activity that results by the covalent attachment of a cholesterol moiety to the C-terminal of the newly generated N-product.|||The dually lipidated hedgehog protein N-product is a morphogen which is essential for a variety of patterning events during development. http://togogenome.org/gene/13616:LOC100019461 ^@ http://purl.uniprot.org/uniprot/F6WII6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/13616:NCLN ^@ http://purl.uniprot.org/uniprot/F7EC67 ^@ Function|||Similarity ^@ Belongs to the nicastrin family.|||May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. http://togogenome.org/gene/13616:AQP11 ^@ http://purl.uniprot.org/uniprot/F7E9A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/13616:CDC37 ^@ http://purl.uniprot.org/uniprot/F6UJW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/13616:SEMA3C ^@ http://purl.uniprot.org/uniprot/F6VKW8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:ORC6 ^@ http://purl.uniprot.org/uniprot/F7EFU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/13616:HAPLN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GM11|||http://purl.uniprot.org/uniprot/A0A5F8H7V8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100019021 ^@ http://purl.uniprot.org/uniprot/F7FQU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RSPH3 ^@ http://purl.uniprot.org/uniprot/F7C597 ^@ Similarity ^@ Belongs to the flagellar radial spoke RSP3 family. http://togogenome.org/gene/13616:LOC100618713 ^@ http://purl.uniprot.org/uniprot/F7EB65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RBM48 ^@ http://purl.uniprot.org/uniprot/F7G7G9 ^@ Similarity ^@ Belongs to the RBM48 family. http://togogenome.org/gene/13616:LOC100022053 ^@ http://purl.uniprot.org/uniprot/A0A5F8H537|||http://purl.uniprot.org/uniprot/F6U0T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/13616:CPM ^@ http://purl.uniprot.org/uniprot/F6RZ59 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/13616:FGF18 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTF4 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:REC8 ^@ http://purl.uniprot.org/uniprot/F6ZPU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/13616:CRHR1 ^@ http://purl.uniprot.org/uniprot/F7GHJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||G-protein coupled receptor for CRH (corticotropin-releasing factor) and UCN (urocortin). Has high affinity for CRH and UCN. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and down-stream effectors, such as adenylate cyclase. Promotes the activation of adenylate cyclase, leading to increased intracellular cAMP levels. Inhibits the activity of the calcium channel CACNA1H. Required for normal embryonic development of the adrenal gland and for normal hormonal responses to stress. Plays a role in the response to anxiogenic stimuli.|||Membrane http://togogenome.org/gene/13616:GJA4 ^@ http://purl.uniprot.org/uniprot/F7E3B7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:METRNL ^@ http://purl.uniprot.org/uniprot/A0A5F8GLB1|||http://purl.uniprot.org/uniprot/F7EE64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the meteorin family.|||Secreted http://togogenome.org/gene/13616:monDomV1R1271 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100012380 ^@ http://purl.uniprot.org/uniprot/F7DNW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TMEM18 ^@ http://purl.uniprot.org/uniprot/F6X0K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM18 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/13616:LOC100015541 ^@ http://purl.uniprot.org/uniprot/A0A5F8G408 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:GINS4 ^@ http://purl.uniprot.org/uniprot/F7F7I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/13616:P2RX3 ^@ http://purl.uniprot.org/uniprot/F7ESP1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/13616:SCML2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY03|||http://purl.uniprot.org/uniprot/F6TM50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/13616:PLA2G2D ^@ http://purl.uniprot.org/uniprot/K7DYR4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/13616:ZMYM6NB ^@ http://purl.uniprot.org/uniprot/K7E0E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Membrane http://togogenome.org/gene/13616:ADAMTS2 ^@ http://purl.uniprot.org/uniprot/F7GAM5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:LOC100022317 ^@ http://purl.uniprot.org/uniprot/F7BJR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/13616:PATL2 ^@ http://purl.uniprot.org/uniprot/F7G5L3 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/13616:CRLS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPH7 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/13616:ERCC2 ^@ http://purl.uniprot.org/uniprot/F7DF10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100017577 ^@ http://purl.uniprot.org/uniprot/F6T305 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/13616:OVOL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GNL2 ^@ http://purl.uniprot.org/uniprot/F7DJF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/13616:AOX1 ^@ http://purl.uniprot.org/uniprot/F6Q3K3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/13616:CHN2 ^@ http://purl.uniprot.org/uniprot/F6XXK5 ^@ Function ^@ GTPase-activating protein for p21-rac. http://togogenome.org/gene/13616:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/F7FV16|||http://purl.uniprot.org/uniprot/K7E2L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Golgi apparatus membrane|||Membrane|||Midbody|||Mitochondrion outer membrane|||autophagosome membrane http://togogenome.org/gene/13616:GNG3 ^@ http://purl.uniprot.org/uniprot/F7GI54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:PGAM1 ^@ http://purl.uniprot.org/uniprot/F6UBE9 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/13616:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQD3 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/13616:OGFRL1 ^@ http://purl.uniprot.org/uniprot/F7G273 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/13616:SPOCK2 ^@ http://purl.uniprot.org/uniprot/F6YTC5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NRAS ^@ http://purl.uniprot.org/uniprot/Q95ME4 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-104 prevents interaction with guanine nucleotide exchange factors (GEFs).|||Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by a GTPase-activating protein (GAP).|||Belongs to the small GTPase superfamily. Ras family.|||Cell membrane|||Golgi apparatus membrane|||Interacts (active GTP-bound form preferentially) with RGS14. Interacts (active GTP-bound form) with RASSF7 (By similarity).|||Palmitoylated by the ZDHHC9-GOLGA7 complex. Depalmitoylated by ABHD17A, ABHD17B and ABHD17C. A continuous cycle of de- and re-palmitoylation regulates rapid exchange between plasma membrane and Golgi.|||Phosphorylation at Ser-89 by STK19 enhances NRAS-association with its downstream effectors.|||Ras proteins bind GDP/GTP and possess intrinsic GTPase activity.|||Ubiquitinated by the BCR(LZTR1) E3 ubiquitin ligase complex at Lys-170 in a non-degradative manner, leading to inhibit Ras signaling by decreasing Ras association with membranes. http://togogenome.org/gene/13616:EVC ^@ http://purl.uniprot.org/uniprot/F6X0A2 ^@ Subcellular Location Annotation ^@ Membrane|||cilium basal body|||cilium membrane http://togogenome.org/gene/13616:VAX1 ^@ http://purl.uniprot.org/uniprot/F7BKU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMX homeobox family.|||Nucleus http://togogenome.org/gene/13616:KIF18B ^@ http://purl.uniprot.org/uniprot/F6R183 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:GPR137B ^@ http://purl.uniprot.org/uniprot/F6Z9G0 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/13616:LOC100014318 ^@ http://purl.uniprot.org/uniprot/F7ASF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R572 ^@ http://purl.uniprot.org/uniprot/A0A5F8G923 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100015945 ^@ http://purl.uniprot.org/uniprot/F7AJ61 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:GIMAP5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLW8|||http://purl.uniprot.org/uniprot/A0A5F8HJY3|||http://purl.uniprot.org/uniprot/A0A5F8HKN7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:SZRD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC08 ^@ Similarity ^@ Belongs to the SZRD1 family. http://togogenome.org/gene/13616:RORB ^@ http://purl.uniprot.org/uniprot/F6QC71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:KHDRBS1 ^@ http://purl.uniprot.org/uniprot/F7E0Y6 ^@ Similarity ^@ Belongs to the KHDRBS family. http://togogenome.org/gene/13616:LOC100027805 ^@ http://purl.uniprot.org/uniprot/F6UIH3 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/13616:BRINP2 ^@ http://purl.uniprot.org/uniprot/F6QEE5 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/13616:TMED1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:LOC100617842 ^@ http://purl.uniprot.org/uniprot/F7ASG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SURF6 ^@ http://purl.uniprot.org/uniprot/F6T186 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/13616:FKTN ^@ http://purl.uniprot.org/uniprot/A0A5F8GS61|||http://purl.uniprot.org/uniprot/F7EQC4 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/13616:ATG9A ^@ http://purl.uniprot.org/uniprot/F6QD19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/13616:PSMB5 ^@ http://purl.uniprot.org/uniprot/F7E8A7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex). Within the 20S core complex, PSMB5 displays a chymotrypsin-like activity.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100028775 ^@ http://purl.uniprot.org/uniprot/F6RTJ8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CCDC47 ^@ http://purl.uniprot.org/uniprot/F6R7Z7 ^@ Subcellular Location Annotation ^@ Membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/13616:CCNF ^@ http://purl.uniprot.org/uniprot/F6Z4F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||centriole|||perinuclear region http://togogenome.org/gene/13616:CAMK2B ^@ http://purl.uniprot.org/uniprot/A0A5F8GQP0|||http://purl.uniprot.org/uniprot/A0A5F8H0C2|||http://purl.uniprot.org/uniprot/A0A5F8HK67|||http://purl.uniprot.org/uniprot/F7G8T0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/13616:CASP3 ^@ http://purl.uniprot.org/uniprot/Q2V579 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:SPPL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/13616:JPH3 ^@ http://purl.uniprot.org/uniprot/F6RTX7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/13616:LOC100013930 ^@ http://purl.uniprot.org/uniprot/A0A5F8HM29 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/13616:TCTE3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H843 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/13616:FLAD1 ^@ http://purl.uniprot.org/uniprot/F6U398 ^@ Function|||Similarity ^@ Catalyzes the adenylation of flavin mononucleotide (FMN) to form flavin adenine dinucleotide (FAD) coenzyme.|||In the C-terminal section; belongs to the PAPS reductase family. FAD1 subfamily.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/13616:RANBP9 ^@ http://purl.uniprot.org/uniprot/F6QUG9 ^@ Similarity ^@ Belongs to the RANBP9/10 family. http://togogenome.org/gene/13616:PPARD ^@ http://purl.uniprot.org/uniprot/F6TVN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:SLCO2B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBE5|||http://purl.uniprot.org/uniprot/F6UFC7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100014017 ^@ http://purl.uniprot.org/uniprot/A0A5F8GF86 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:CDC34 ^@ http://purl.uniprot.org/uniprot/F7BV64 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:RAG2 ^@ http://purl.uniprot.org/uniprot/F6YI02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAG2 family.|||Nucleus http://togogenome.org/gene/13616:TMEM33 ^@ http://purl.uniprot.org/uniprot/F7A1Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/13616:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2D3|||http://purl.uniprot.org/uniprot/A0A5F8GIK7|||http://purl.uniprot.org/uniprot/A0A5F8HBN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:IPO11 ^@ http://purl.uniprot.org/uniprot/F6Y6Y1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:BARX2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGY4|||http://purl.uniprot.org/uniprot/F6T8B5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:AIMP2 ^@ http://purl.uniprot.org/uniprot/F7ELU9 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/13616:C1H10orf90 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKU2 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/13616:NOP58 ^@ http://purl.uniprot.org/uniprot/F7ATY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/13616:LOC100027842 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMJ6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:MAPK6 ^@ http://purl.uniprot.org/uniprot/F6V2H6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/13616:RAB33B ^@ http://purl.uniprot.org/uniprot/A0A5F8G3L4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/13616:FAM118B ^@ http://purl.uniprot.org/uniprot/A0A5F8GPM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM118 family.|||Cajal body|||May play a role in Cajal bodies formation. http://togogenome.org/gene/13616:NR2C2 ^@ http://purl.uniprot.org/uniprot/F6UFF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:SENP8 ^@ http://purl.uniprot.org/uniprot/F6W1R5 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/13616:EBF4 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4V7|||http://purl.uniprot.org/uniprot/A0A5F8GSY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/13616:FEZ1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRW3 ^@ Similarity ^@ Belongs to the zygin family. http://togogenome.org/gene/13616:GSTK1 ^@ http://purl.uniprot.org/uniprot/F7G7K0 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/13616:HIGD1B ^@ http://purl.uniprot.org/uniprot/F6T5E4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/13616:FAM19A2 ^@ http://purl.uniprot.org/uniprot/F6X1T2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/13616:SLC51A ^@ http://purl.uniprot.org/uniprot/F6XC44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ATPAF2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/13616:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2V4|||http://purl.uniprot.org/uniprot/A0A5F8GB96|||http://purl.uniprot.org/uniprot/A0A5F8GJH2|||http://purl.uniprot.org/uniprot/A0A5F8GU92|||http://purl.uniprot.org/uniprot/A0A5F8HJ31|||http://purl.uniprot.org/uniprot/F6TK46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/13616:LOC100021655 ^@ http://purl.uniprot.org/uniprot/F6PZL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPL17 ^@ http://purl.uniprot.org/uniprot/F7GBR1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/13616:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/A0A5F8GEG0 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/13616:ALG5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX04|||http://purl.uniprot.org/uniprot/F6TTN8 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/13616:GTPBP10 ^@ http://purl.uniprot.org/uniprot/F7F7T0 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/13616:KEG11_p05 ^@ http://purl.uniprot.org/uniprot/Q65CI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Core subunit of respiratory chain NADH dehydrogenase (Complex I) which is composed of 45 different subunits.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LOC100021232 ^@ http://purl.uniprot.org/uniprot/F7F6F9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/13616:IFN7 ^@ http://purl.uniprot.org/uniprot/A8E6F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Secreted http://togogenome.org/gene/13616:HDAC3 ^@ http://purl.uniprot.org/uniprot/F7D539 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4), and some other non-histone substrates. Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/13616:SYS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYS1 family.|||Golgi apparatus membrane|||Interacts with ARFRP1.|||Involved in protein trafficking. May serve as a receptor for ARFRP1.|||Membrane http://togogenome.org/gene/13616:SELENBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the selenium-binding protein family.|||Catalyzes the oxidation of methanethiol, an organosulfur compound known to be produced in substantial amounts by gut bacteria. Selenium-binding protein which may be involved in the sensing of reactive xenobiotics in the cytoplasm. May be involved in intra-Golgi protein transport.|||Interacts with USP33.|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/13616:LOC100617074 ^@ http://purl.uniprot.org/uniprot/F6UYA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100021431 ^@ http://purl.uniprot.org/uniprot/F6T313 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:TMEM9 ^@ http://purl.uniprot.org/uniprot/F6TG53 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/13616:SLC25A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0C3|||http://purl.uniprot.org/uniprot/F6SW34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Interacts with PPIF; the interaction is impaired by CsA.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:APEX2 ^@ http://purl.uniprot.org/uniprot/F7CHS1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/13616:IDO1 ^@ http://purl.uniprot.org/uniprot/B3Y9H8 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/13616:KLC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7Y9|||http://purl.uniprot.org/uniprot/A0A5F8GHK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/13616:CKAP5 ^@ http://purl.uniprot.org/uniprot/F6W5T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOG/XMAP215 family.|||kinetochore http://togogenome.org/gene/13616:XPO7 ^@ http://purl.uniprot.org/uniprot/F6X9J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:MED4 ^@ http://purl.uniprot.org/uniprot/F6SQB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:VN2R537 ^@ http://purl.uniprot.org/uniprot/F7G4E3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100025872 ^@ http://purl.uniprot.org/uniprot/F6W095 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/13616:T2R24 ^@ http://purl.uniprot.org/uniprot/Q2AB95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2J1|||http://purl.uniprot.org/uniprot/A0A5F8H3K3|||http://purl.uniprot.org/uniprot/F6ZWK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/13616:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDV0|||http://purl.uniprot.org/uniprot/A0A5F8GQY9|||http://purl.uniprot.org/uniprot/F6UJJ9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin.|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/13616:NR2F6 ^@ http://purl.uniprot.org/uniprot/F7FUW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:RIOK1 ^@ http://purl.uniprot.org/uniprot/F6Y7X8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/13616:SLC27A3 ^@ http://purl.uniprot.org/uniprot/F6WFG8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:SPACA4 ^@ http://purl.uniprot.org/uniprot/F7C1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPACA4/bouncer family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100020427 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TMEM182 ^@ http://purl.uniprot.org/uniprot/F7DZ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC25A47 ^@ http://purl.uniprot.org/uniprot/F7AZE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:LOC100029759 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEW3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LSM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||Interacts with SLBP; interaction with SLBP occurs when histone mRNA is being rapidly degraded during the S phase. LSm subunits form a heteromer with a donut shape.|||P-body|||Plays a role in the degradation of histone mRNAs, the only eukaryotic mRNAs that are not polyadenylated. Probably also part of an LSm subunits-containing complex involved in the general process of mRNA degradation. http://togogenome.org/gene/13616:DGCR2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ68|||http://purl.uniprot.org/uniprot/F7EH13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SLC7A6 ^@ http://purl.uniprot.org/uniprot/F7A4K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TMEM178A ^@ http://purl.uniprot.org/uniprot/F7EYJ5 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/13616:LOC100019541 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2T9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 59 family. http://togogenome.org/gene/13616:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGM9|||http://purl.uniprot.org/uniprot/A0A5F8GUJ2|||http://purl.uniprot.org/uniprot/A0A5F8H9N9|||http://purl.uniprot.org/uniprot/F7BZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/13616:TWISTNB ^@ http://purl.uniprot.org/uniprot/F7F5A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/13616:RPS4X ^@ http://purl.uniprot.org/uniprot/O62738 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS4 family.|||Cytoplasm|||Identified in a IGF2BP1-dependent mRNP granule complex containing untranslated mRNAs. http://togogenome.org/gene/13616:GBF1 ^@ http://purl.uniprot.org/uniprot/F6SPN8 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/13616:PTRF ^@ http://purl.uniprot.org/uniprot/F7BYL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/13616:monDomV1R1236 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC10A2 ^@ http://purl.uniprot.org/uniprot/F6XEC4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane|||Monomer and homodimer. http://togogenome.org/gene/13616:SGCB ^@ http://purl.uniprot.org/uniprot/A0A5F8GTR0|||http://purl.uniprot.org/uniprot/F7EMD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Cross-link to form 2 major subcomplexes: one consisting of SGCB, SGCD and SGCG and the other consisting of SGCB and SGCD. The association between SGCB and SGCG is particularly strong while SGCA is loosely associated with the other sarcoglycans.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/13616:LOC100009821 ^@ http://purl.uniprot.org/uniprot/F7ARS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the U1 snRNP. The U1 snRNP is composed of the U1 snRNA and the 7 core Sm proteins SNRPB, SNRPD1, SNRPD2, SNRPD3, SNRPE, SNRPF and SNRPG that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins SNRNP70/U1-70K, SNRPA/U1-A and SNRPC/U1-C. SNRPC/U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA (By similarity). Interacts (via N-terminus) with TIA1 (via C-terminus); thereby promoting spliceosomal U1 snRNP recruitment to 5' splice sites (By similarity).|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. SNRPC/U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus http://togogenome.org/gene/13616:NRXN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HEQ1|||http://purl.uniprot.org/uniprot/F7EPR9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MRRF ^@ http://purl.uniprot.org/uniprot/A0A5F8GW35 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/13616:EPB41 ^@ http://purl.uniprot.org/uniprot/F7F455 ^@ Subcellular Location Annotation ^@ Nucleus|||cell cortex http://togogenome.org/gene/13616:SAT1 ^@ http://purl.uniprot.org/uniprot/F7BJU3 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Homodimer. http://togogenome.org/gene/13616:WAS ^@ http://purl.uniprot.org/uniprot/F6SA08 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100019894 ^@ http://purl.uniprot.org/uniprot/F6YW40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:KDR ^@ http://purl.uniprot.org/uniprot/F7DLA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLC8|||http://purl.uniprot.org/uniprot/A0A5F8H4U5|||http://purl.uniprot.org/uniprot/A0A5F8HK66|||http://purl.uniprot.org/uniprot/F6TI85 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/13616:MED16 ^@ http://purl.uniprot.org/uniprot/F6U312 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:ACTN1 ^@ http://purl.uniprot.org/uniprot/F6SUP3 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/13616:UPF2 ^@ http://purl.uniprot.org/uniprot/F7G5X8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:LOC100020223 ^@ http://purl.uniprot.org/uniprot/F7ECU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/13616:CAND1 ^@ http://purl.uniprot.org/uniprot/F7GD42 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/13616:RRP15 ^@ http://purl.uniprot.org/uniprot/F6SY45 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/13616:BOD1 ^@ http://purl.uniprot.org/uniprot/F6Z5Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BOD1 family.|||centrosome|||kinetochore http://togogenome.org/gene/13616:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPP4|||http://purl.uniprot.org/uniprot/F6XUV5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators. May play a critical role in early brain and skin development.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/13616:SUCLA2 ^@ http://purl.uniprot.org/uniprot/F6S738 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-specific succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.|||Belongs to the succinate/malate CoA ligase beta subunit family. ATP-specific subunit beta subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit. The beta subunit determines specificity for ATP.|||Mitochondrion http://togogenome.org/gene/13616:LTBP3 ^@ http://purl.uniprot.org/uniprot/F6XT41 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:GTF2A1 ^@ http://purl.uniprot.org/uniprot/F7EVS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/13616:GOT1L1 ^@ http://purl.uniprot.org/uniprot/F7C035 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/13616:ZFHX4 ^@ http://purl.uniprot.org/uniprot/F7BTH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DECR2 ^@ http://purl.uniprot.org/uniprot/F7E6L0 ^@ Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. 2,4-dienoyl-CoA reductase subfamily.|||Monomer, dimer and oligomer. http://togogenome.org/gene/13616:LCMT1 ^@ http://purl.uniprot.org/uniprot/F7ATD3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/13616:UBE2C ^@ http://purl.uniprot.org/uniprot/F6TXY0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:NUMB ^@ http://purl.uniprot.org/uniprot/A0A5F8G359|||http://purl.uniprot.org/uniprot/A0A5F8GIT3|||http://purl.uniprot.org/uniprot/F7CD96 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Plays a role in the process of neurogenesis. http://togogenome.org/gene/13616:LOC100031189 ^@ http://purl.uniprot.org/uniprot/F7BB81 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Component of intercellular desmosome junctions. Involved in the interaction of plaque proteins and intermediate filaments mediating cell-cell adhesion.|||Membrane|||desmosome http://togogenome.org/gene/13616:LOC100013718 ^@ http://purl.uniprot.org/uniprot/A0A5F8HLT6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 22 family. http://togogenome.org/gene/13616:SCRN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7T1|||http://purl.uniprot.org/uniprot/F7GAY1 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/13616:DCTN6 ^@ http://purl.uniprot.org/uniprot/F7C606 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin subunits 5/6 family. Dynactin subunit 6 subfamily.|||cytoskeleton http://togogenome.org/gene/13616:CENPL ^@ http://purl.uniprot.org/uniprot/F6RA61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/13616:BROX ^@ http://purl.uniprot.org/uniprot/F6V683 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane http://togogenome.org/gene/13616:MYO5C ^@ http://purl.uniprot.org/uniprot/F6W1D0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:MMP26 ^@ http://purl.uniprot.org/uniprot/K7E0A2 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:PEMT ^@ http://purl.uniprot.org/uniprot/F6WK67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:LOC100016989 ^@ http://purl.uniprot.org/uniprot/F6WH69 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/13616:MRPL11 ^@ http://purl.uniprot.org/uniprot/F6Z7R6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/13616:LOC100028314 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CFAP126 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAU4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the Flattop family. http://togogenome.org/gene/13616:LEF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT74|||http://purl.uniprot.org/uniprot/F6ZBJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCF/LEF family.|||Nucleus http://togogenome.org/gene/13616:LOC100019929 ^@ http://purl.uniprot.org/uniprot/F6Z4S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100016866 ^@ http://purl.uniprot.org/uniprot/A0A5F8G341 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100027097 ^@ http://purl.uniprot.org/uniprot/F6SRZ5 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:CA1 ^@ http://purl.uniprot.org/uniprot/Q8HY33 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide.|||Cytoplasm|||Inhibited by acetazolamide. http://togogenome.org/gene/13616:RARA ^@ http://purl.uniprot.org/uniprot/A0A5F8GD96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:CRBN ^@ http://purl.uniprot.org/uniprot/F6SVH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/13616:ADRA2A ^@ http://purl.uniprot.org/uniprot/F6S9H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NEMP2 ^@ http://purl.uniprot.org/uniprot/F6UZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NEMP family.|||Nucleus inner membrane http://togogenome.org/gene/13616:MODO-T2R28 ^@ http://purl.uniprot.org/uniprot/Q2AB91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|||Membrane http://togogenome.org/gene/13616:GGH ^@ http://purl.uniprot.org/uniprot/F7FU03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C26 family.|||extracellular space http://togogenome.org/gene/13616:LOC100011334 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHD7|||http://purl.uniprot.org/uniprot/F6VUG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/13616:NAB1 ^@ http://purl.uniprot.org/uniprot/F6UHF8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAB family.|||Homomultimers may associate with EGR1 bound to DNA.|||Nucleus http://togogenome.org/gene/13616:FLT1 ^@ http://purl.uniprot.org/uniprot/F7EY52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MBTPS2 ^@ http://purl.uniprot.org/uniprot/F7GI63 ^@ Similarity ^@ Belongs to the peptidase M50A family. http://togogenome.org/gene/13616:BCL2A1 ^@ http://purl.uniprot.org/uniprot/F6SFL4 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/13616:LOC100010708 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100010481 ^@ http://purl.uniprot.org/uniprot/F7B9Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/13616:GPRC6A ^@ http://purl.uniprot.org/uniprot/F6ZXM6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:ELOVL5 ^@ http://purl.uniprot.org/uniprot/F6ZMF1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/13616:LOC100022343 ^@ http://purl.uniprot.org/uniprot/F7BJQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/13616:TROVE2 ^@ http://purl.uniprot.org/uniprot/F7CE78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/13616:PTGDR2 ^@ http://purl.uniprot.org/uniprot/F7FWX0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100030236 ^@ http://purl.uniprot.org/uniprot/F6VQ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:S1PR3 ^@ http://purl.uniprot.org/uniprot/F7DSW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:PANX1 ^@ http://purl.uniprot.org/uniprot/F6WB40 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||S-nitrosylation inhibits channel currents and ATP release.|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/13616:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/F7G392 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/13616:PPARGC1B ^@ http://purl.uniprot.org/uniprot/F6VCD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SPIN1 ^@ http://purl.uniprot.org/uniprot/F7D899 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/13616:DHX58 ^@ http://purl.uniprot.org/uniprot/F7G6X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/13616:ACTL6B ^@ http://purl.uniprot.org/uniprot/F6QIK5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:LOC100011116 ^@ http://purl.uniprot.org/uniprot/F6W9Z1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/13616:NPR2 ^@ http://purl.uniprot.org/uniprot/F6XTY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane http://togogenome.org/gene/13616:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A5F8G2H8 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/13616:LOC100012477 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIQ8|||http://purl.uniprot.org/uniprot/A0A5F8H5T9|||http://purl.uniprot.org/uniprot/F7E3L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/13616:LHFPL2 ^@ http://purl.uniprot.org/uniprot/F6X4R7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100021601 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100011610 ^@ http://purl.uniprot.org/uniprot/F7G461 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:PHACTR2 ^@ http://purl.uniprot.org/uniprot/K7E1S0 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/13616:AGPAT4 ^@ http://purl.uniprot.org/uniprot/F7CDG3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:LOC100028858 ^@ http://purl.uniprot.org/uniprot/F7D4J2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100010571 ^@ http://purl.uniprot.org/uniprot/F7BD00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/13616:TUFM ^@ http://purl.uniprot.org/uniprot/F7AJ98 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/13616:MFSD14A ^@ http://purl.uniprot.org/uniprot/F7FAI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/13616:PELP1 ^@ http://purl.uniprot.org/uniprot/F6U4E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:LOC100030375 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FABP2 ^@ http://purl.uniprot.org/uniprot/F7GAR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. http://togogenome.org/gene/13616:FAM69B ^@ http://purl.uniprot.org/uniprot/A0A5F8GIR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:GALT ^@ http://purl.uniprot.org/uniprot/F6YSD0 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/13616:TSPAN17 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:BCO2 ^@ http://purl.uniprot.org/uniprot/F6TNK3 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/13616:PSMD7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ46 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/13616:ADGRG1 ^@ http://purl.uniprot.org/uniprot/F7GKY6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/13616:SMOC1 ^@ http://purl.uniprot.org/uniprot/F6VWV4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SNTB2 ^@ http://purl.uniprot.org/uniprot/F6WEL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/13616:SLC34A3 ^@ http://purl.uniprot.org/uniprot/F6XEY4 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100019065 ^@ http://purl.uniprot.org/uniprot/F6X583 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100023248 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBU8 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/13616:NR2E1 ^@ http://purl.uniprot.org/uniprot/F7AL53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:FGD2 ^@ http://purl.uniprot.org/uniprot/F7FYW3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:MID2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GGN9|||http://purl.uniprot.org/uniprot/F6TIP4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:REXO2 ^@ http://purl.uniprot.org/uniprot/F6SVD7 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/13616:ACTRT3 ^@ http://purl.uniprot.org/uniprot/F7DSU1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:ACTL9 ^@ http://purl.uniprot.org/uniprot/F7FMI7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:PFKFB2 ^@ http://purl.uniprot.org/uniprot/F7GE45 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/13616:SLC10A4 ^@ http://purl.uniprot.org/uniprot/F7EN54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/13616:NEU4 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF43 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/13616:TWSG1 ^@ http://purl.uniprot.org/uniprot/F7BT45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/13616:LOC100010178 ^@ http://purl.uniprot.org/uniprot/F7AXX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/13616:ELF1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQG3|||http://purl.uniprot.org/uniprot/A0A5F8GTH7|||http://purl.uniprot.org/uniprot/F6YMD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:PCYT1B ^@ http://purl.uniprot.org/uniprot/A0A5F8GGJ1|||http://purl.uniprot.org/uniprot/F6ZNF7 ^@ Function|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Catalyzes the key rate-limiting step in the CDP-choline pathway for phosphatidylcholine biosynthesis. http://togogenome.org/gene/13616:LOC100010741 ^@ http://purl.uniprot.org/uniprot/F6TRQ7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:DCN ^@ http://purl.uniprot.org/uniprot/F6Q8B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN. Interacts with DPT.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/13616:EIF4A3 ^@ http://purl.uniprot.org/uniprot/F7GE48 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:FAM65B ^@ http://purl.uniprot.org/uniprot/F7FSX9 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the RIPOR family.|||Cell membrane|||Membrane|||cytoskeleton|||filopodium|||stereocilium membrane http://togogenome.org/gene/13616:LOC107651329 ^@ http://purl.uniprot.org/uniprot/F7DP98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CDK10 ^@ http://purl.uniprot.org/uniprot/F7C8L6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:CUTC ^@ http://purl.uniprot.org/uniprot/A0A5F8H7I6 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/13616:PER1 ^@ http://purl.uniprot.org/uniprot/F7AX09 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/13616:AHSA2 ^@ http://purl.uniprot.org/uniprot/F7CC22 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/13616:ZDHHC23 ^@ http://purl.uniprot.org/uniprot/F7CCF4 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/13616:TMEM161B ^@ http://purl.uniprot.org/uniprot/F7D4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM161 family.|||Membrane http://togogenome.org/gene/13616:TMEM30A ^@ http://purl.uniprot.org/uniprot/F7B4F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC50/LEM3 family.|||Cell membrane|||Golgi apparatus|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/13616:LOC103095228 ^@ http://purl.uniprot.org/uniprot/K7E2B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/13616:NAPB ^@ http://purl.uniprot.org/uniprot/F7FDH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/13616:AASS ^@ http://purl.uniprot.org/uniprot/F6S3L1 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/13616:VIPR2 ^@ http://purl.uniprot.org/uniprot/F7CG94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GPAT3 ^@ http://purl.uniprot.org/uniprot/F6Z9L3 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:ERO1B ^@ http://purl.uniprot.org/uniprot/F7CL82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:NDUFA11 ^@ http://purl.uniprot.org/uniprot/F7FWB2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:POLR2B ^@ http://purl.uniprot.org/uniprot/K7E2Q4 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/13616:LOC100019646 ^@ http://purl.uniprot.org/uniprot/F7E936 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:POLR2C ^@ http://purl.uniprot.org/uniprot/F7CLY1 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/13616:HSF4 ^@ http://purl.uniprot.org/uniprot/F7C7M8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/13616:ACADS ^@ http://purl.uniprot.org/uniprot/F6Q3F7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/13616:ISM1 ^@ http://purl.uniprot.org/uniprot/F7ERG0 ^@ Similarity ^@ Belongs to the isthmin family. http://togogenome.org/gene/13616:SLC9A2 ^@ http://purl.uniprot.org/uniprot/F7DZW2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Interacts with CHP1 and CHP2.|||Membrane http://togogenome.org/gene/13616:VN2R653 ^@ http://purl.uniprot.org/uniprot/F6ZT09 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:SNX17 ^@ http://purl.uniprot.org/uniprot/F7EIH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome|||Membrane http://togogenome.org/gene/13616:LOC100032638 ^@ http://purl.uniprot.org/uniprot/F6TJP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/13616:LOC100028222 ^@ http://purl.uniprot.org/uniprot/A0A5F8HAV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1210 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ITPA ^@ http://purl.uniprot.org/uniprot/F7CG88 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes the non-canonical purine (dITP) as well as 2'-deoxy-N-6-hydroxylaminopurine triphosphate (dHAPTP) and xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/13616:LOC100024951 ^@ http://purl.uniprot.org/uniprot/F7GIC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:NOL12 ^@ http://purl.uniprot.org/uniprot/F6WB47 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP17 family.|||Interacts with KIAA1191.|||nucleolus http://togogenome.org/gene/13616:GET4 ^@ http://purl.uniprot.org/uniprot/F6PGG6 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/13616:VIPAS39 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFK5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/13616:LOC100617710 ^@ http://purl.uniprot.org/uniprot/F6SRP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SFR1 ^@ http://purl.uniprot.org/uniprot/F7FIV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/13616:PKMYT1 ^@ http://purl.uniprot.org/uniprot/F7F1V1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:CETP ^@ http://purl.uniprot.org/uniprot/F7FMG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Secreted http://togogenome.org/gene/13616:POU3F4 ^@ http://purl.uniprot.org/uniprot/F6X0R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-3 subfamily.|||Nucleus http://togogenome.org/gene/13616:FAM13A ^@ http://purl.uniprot.org/uniprot/A0A5F8GP38|||http://purl.uniprot.org/uniprot/F6REA1 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/13616:CENPA ^@ http://purl.uniprot.org/uniprot/A0A5F8GXB1|||http://purl.uniprot.org/uniprot/A0A5F8HEF8 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/13616:LOC103101397 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4H5 ^@ Similarity ^@ Belongs to the TMEM176 family. http://togogenome.org/gene/13616:LOC100016358 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4P1 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/13616:MRPL19 ^@ http://purl.uniprot.org/uniprot/F7DQT5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/13616:HDC ^@ http://purl.uniprot.org/uniprot/F7CVL5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/13616:JUN ^@ http://purl.uniprot.org/uniprot/F7DYE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/13616:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC17|||http://purl.uniprot.org/uniprot/F6PQG6 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:LOC100012717 ^@ http://purl.uniprot.org/uniprot/F6VDR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Involved in actively transporting phosphate into cells via Na(+) cotransport.|||Membrane http://togogenome.org/gene/13616:TNFRSF11B ^@ http://purl.uniprot.org/uniprot/F6VWG6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:KIAA0196 ^@ http://purl.uniprot.org/uniprot/F6WI36 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/13616:LOC100618565 ^@ http://purl.uniprot.org/uniprot/F7D8M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PLPPR1 ^@ http://purl.uniprot.org/uniprot/F6SRJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Cell membrane|||May play a role in neurite outgrowth and neurogenesis.|||Membrane|||neuron projection http://togogenome.org/gene/13616:GPX7 ^@ http://purl.uniprot.org/uniprot/F6TRR3 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/13616:LOC100618184 ^@ http://purl.uniprot.org/uniprot/F6RM38 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Present in the thicker 16-17 nm junctions of mammalian lens fiber cells, where it may contribute to cell junctional organization. Acts as a receptor for calmodulin. May play an important role in both lens development and cataractogenesis. http://togogenome.org/gene/13616:SSR2 ^@ http://purl.uniprot.org/uniprot/F6V4W6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/13616:PDHA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GC60|||http://purl.uniprot.org/uniprot/F7AF77 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/13616:QTRT2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPI6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit QTRT1 and an accessory subunit QTRT2.|||Mitochondrion outer membrane|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/13616:NSMCE4A ^@ http://purl.uniprot.org/uniprot/F7BUN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/13616:GADD45GIP1 ^@ http://purl.uniprot.org/uniprot/F6QWU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a negative regulator of G1 to S cell cycle phase progression by inhibiting cyclin-dependent kinases. Inhibitory effects are additive with GADD45 proteins but occurs also in the absence of GADD45 proteins. Acts as a repressor of the orphan nuclear receptor NR4A1 by inhibiting AB domain-mediated transcriptional activity. May be involved in the hormone-mediated regulation of NR4A1 transcriptional activity. May play a role in mitochondrial protein synthesis.|||Belongs to the mitochondrion-specific ribosomal protein mL64 family.|||Mitochondrion|||Nucleus http://togogenome.org/gene/13616:CRELD1 ^@ http://purl.uniprot.org/uniprot/F6YLH8 ^@ Caution|||Similarity ^@ Belongs to the CRELD family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SLC26A11 ^@ http://purl.uniprot.org/uniprot/A0A5F8GUQ2|||http://purl.uniprot.org/uniprot/F7CWJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:monDomV1R1281 ^@ http://purl.uniprot.org/uniprot/F7B7S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100027995 ^@ http://purl.uniprot.org/uniprot/F7G844 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A5F8GQY8|||http://purl.uniprot.org/uniprot/A0A5F8HCM9 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/13616:PTPN11 ^@ http://purl.uniprot.org/uniprot/F6WVD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:ELP3 ^@ http://purl.uniprot.org/uniprot/F6PGK3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/13616:RPP14 ^@ http://purl.uniprot.org/uniprot/F7GLS4 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family. http://togogenome.org/gene/13616:SUMO1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/13616:TADA2A ^@ http://purl.uniprot.org/uniprot/F7GFC2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GRAMD1B ^@ http://purl.uniprot.org/uniprot/F7G3Z6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:CREBBP ^@ http://purl.uniprot.org/uniprot/F7E905 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:CD99L2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5D0|||http://purl.uniprot.org/uniprot/K7E003 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/13616:GSDMB ^@ http://purl.uniprot.org/uniprot/F7GCF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:HNF1A ^@ http://purl.uniprot.org/uniprot/F6Q5D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/13616:SLITRK1 ^@ http://purl.uniprot.org/uniprot/F6U9H0 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/13616:LOC100013748 ^@ http://purl.uniprot.org/uniprot/F7EEM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:EMP1 ^@ http://purl.uniprot.org/uniprot/F6PGV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/13616:DDRGK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8I2 ^@ Similarity ^@ Belongs to the DDRGK1 family. http://togogenome.org/gene/13616:CRB1 ^@ http://purl.uniprot.org/uniprot/F6UYP3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PSMC1 ^@ http://purl.uniprot.org/uniprot/F6Z7G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:PARP9 ^@ http://purl.uniprot.org/uniprot/F6UNV4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/13616:BNIP3L ^@ http://purl.uniprot.org/uniprot/F6S038 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIP3 family.|||Membrane http://togogenome.org/gene/13616:ANO10 ^@ http://purl.uniprot.org/uniprot/F6UJG9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC100617922 ^@ http://purl.uniprot.org/uniprot/F6WN41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PTPRA ^@ http://purl.uniprot.org/uniprot/A0A5F8H677|||http://purl.uniprot.org/uniprot/F7G6B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SFN ^@ http://purl.uniprot.org/uniprot/F7FY05 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A5F8GL01|||http://purl.uniprot.org/uniprot/A0A5F8GN96|||http://purl.uniprot.org/uniprot/F6THZ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PEA15 ^@ http://purl.uniprot.org/uniprot/F6RDS5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:CTU2 ^@ http://purl.uniprot.org/uniprot/F7B1B4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTU2/NCS2 family.|||Component of a complex at least composed of URM1, CTU2/NCS2 and CTU1/ATPBD3.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with CTU1/ATPBD3 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/13616:ANXA13 ^@ http://purl.uniprot.org/uniprot/F6W0Q1 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/13616:AP3D1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H916 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:monDomV1R1215 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PTPRN ^@ http://purl.uniprot.org/uniprot/A0A5F8GHM8|||http://purl.uniprot.org/uniprot/F6RCL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 8 subfamily.|||Membrane|||secretory vesicle membrane http://togogenome.org/gene/13616:ST3GAL4 ^@ http://purl.uniprot.org/uniprot/F6U7G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:LACC1 ^@ http://purl.uniprot.org/uniprot/F7GGA6 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/13616:NME7 ^@ http://purl.uniprot.org/uniprot/F6Q3R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/13616:TMEM234 ^@ http://purl.uniprot.org/uniprot/F7FEY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/13616:SUGP2 ^@ http://purl.uniprot.org/uniprot/F7DSD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ZHX3 ^@ http://purl.uniprot.org/uniprot/F6TAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/13616:HENMT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3T7|||http://purl.uniprot.org/uniprot/F7GDM0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/13616:VN2R614 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8T7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQW4|||http://purl.uniprot.org/uniprot/F6T459 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GNRHR ^@ http://purl.uniprot.org/uniprot/F7A026 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC25A12 ^@ http://purl.uniprot.org/uniprot/A0A5F8GID9|||http://purl.uniprot.org/uniprot/A0A5F8HDF6|||http://purl.uniprot.org/uniprot/F7CUN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FGF10 ^@ http://purl.uniprot.org/uniprot/A0A5F8H867 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:SPA17 ^@ http://purl.uniprot.org/uniprot/O62771 ^@ Function|||Subcellular Location Annotation|||Subunit|||Tissue Specificity ^@ Homodimer. May interact with ROPN1 (By similarity).|||Membrane|||Sperm surface zona pellucida binding protein. Helps to bind spermatozoa to the zona pellucida with high affinity. Might function in binding zona pellucida and carbohydrates (By similarity).|||Testis- and sperm-specific. http://togogenome.org/gene/13616:CD4 ^@ http://purl.uniprot.org/uniprot/A6MAP0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/13616:B3GNT9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HGZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:VN2R634 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5Y0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:VN2R585 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPF1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:DDA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW14 ^@ Similarity ^@ Belongs to the DDA1 family. http://togogenome.org/gene/13616:GNA13 ^@ http://purl.uniprot.org/uniprot/F6WQL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-alpha family. G(12) subfamily.|||Membrane http://togogenome.org/gene/13616:PKIA ^@ http://purl.uniprot.org/uniprot/F7DH47 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/13616:EML6 ^@ http://purl.uniprot.org/uniprot/F6WIY1 ^@ Function|||Similarity ^@ Belongs to the WD repeat EMAP family.|||May modify the assembly dynamics of microtubules, such that microtubules are slightly longer, but more dynamic. http://togogenome.org/gene/13616:MEIG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMA0 ^@ Function|||Similarity ^@ Belongs to the MEIG1 family.|||Essential for spermiogenesis. http://togogenome.org/gene/13616:LOC100013141 ^@ http://purl.uniprot.org/uniprot/F7ATB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:C1H5orf24 ^@ http://purl.uniprot.org/uniprot/F6ULE0 ^@ Similarity ^@ Belongs to the UPF0461 family. http://togogenome.org/gene/13616:EDC4 ^@ http://purl.uniprot.org/uniprot/F7G5P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat EDC4 family.|||P-body http://togogenome.org/gene/13616:ESRRG ^@ http://purl.uniprot.org/uniprot/F6QPZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/13616:EI24 ^@ http://purl.uniprot.org/uniprot/F6VW60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EI24 family.|||Membrane http://togogenome.org/gene/13616:TMEM150C ^@ http://purl.uniprot.org/uniprot/A0A5F8HA54|||http://purl.uniprot.org/uniprot/F7DER9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC103106467 ^@ http://purl.uniprot.org/uniprot/F6ZRZ5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/13616:PAQR4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H792 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/13616:FAM126B ^@ http://purl.uniprot.org/uniprot/F7F3H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:CDH7 ^@ http://purl.uniprot.org/uniprot/F7CBX9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:C2H17orf80 ^@ http://purl.uniprot.org/uniprot/F7AKX6 ^@ Function|||Similarity ^@ Belongs to the ATPase F chain family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane. http://togogenome.org/gene/13616:CA3 ^@ http://purl.uniprot.org/uniprot/F6U1Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/13616:NCAPH ^@ http://purl.uniprot.org/uniprot/F7FTE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/13616:BMP10 ^@ http://purl.uniprot.org/uniprot/F7GDY5 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/13616:ADAMTS17 ^@ http://purl.uniprot.org/uniprot/F6TYF6 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:LOC100023598 ^@ http://purl.uniprot.org/uniprot/F7DJC0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:TLR9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GTX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Endosome|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/13616:LOC100618906 ^@ http://purl.uniprot.org/uniprot/F7DM99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CPSF3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDB0|||http://purl.uniprot.org/uniprot/F7D3K9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ABR ^@ http://purl.uniprot.org/uniprot/A0A5F8GDH1|||http://purl.uniprot.org/uniprot/A0A5F8HD17 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/13616:RNPC3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHH3|||http://purl.uniprot.org/uniprot/F6PKA9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the U11/U12 snRNPs that are part of the U12-type spliceosome. Found in a complex with m(7)G-capped U12 snRNA. Interacts with PDCD7.|||Nucleus|||Participates in pre-mRNA U12-dependent splicing, performed by the minor spliceosome which removes U12-type introns. U12-type introns comprises less than 1% of all non-coding sequences. Binds to the 3'-stem-loop of m(7)G-capped U12 snRNA. http://togogenome.org/gene/13616:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/13616:QARS ^@ http://purl.uniprot.org/uniprot/F7GJG2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:MAN1B1 ^@ http://purl.uniprot.org/uniprot/F6TLC5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/13616:FAM96A ^@ http://purl.uniprot.org/uniprot/F7F5F3 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/13616:TAS2R38 ^@ http://purl.uniprot.org/uniprot/Q2AB89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:PODXL2 ^@ http://purl.uniprot.org/uniprot/F6YSG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100023968 ^@ http://purl.uniprot.org/uniprot/F7D3V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM187 family.|||Membrane http://togogenome.org/gene/13616:RPL37 ^@ http://purl.uniprot.org/uniprot/F7BFG9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/13616:TLR4 ^@ http://purl.uniprot.org/uniprot/F6Y6W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/13616:SBDS ^@ http://purl.uniprot.org/uniprot/F7G494 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/13616:TSPAN12 ^@ http://purl.uniprot.org/uniprot/F6WFC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:CLIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDT4|||http://purl.uniprot.org/uniprot/A0A5F8HES8|||http://purl.uniprot.org/uniprot/F6YGW0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:LOC100010989 ^@ http://purl.uniprot.org/uniprot/A0A5F8H981 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:SLC39A1 ^@ http://purl.uniprot.org/uniprot/F6S483 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:P2RY13 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LANCL1 ^@ http://purl.uniprot.org/uniprot/F7FRY9 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/13616:LOC100617303 ^@ http://purl.uniprot.org/uniprot/F7BMV5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/13616:LHX2 ^@ http://purl.uniprot.org/uniprot/F6X3T3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TMC8 ^@ http://purl.uniprot.org/uniprot/F6T5J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/13616:GSTT2B ^@ http://purl.uniprot.org/uniprot/F6RZ22 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/13616:LOC100032151 ^@ http://purl.uniprot.org/uniprot/F7BYT8 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism. Has also been shown to have O-methyltransferase activity that methylates glutamate residues of target proteins to form gamma-glutamyl methyl ester residues. Possibly methylates PCNA, suggesting it is involved in the DNA damage response.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/13616:ADSSL1 ^@ http://purl.uniprot.org/uniprot/F6TXD9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first commited step in the biosynthesis of AMP from IMP.|||Component of the purine nucleotide cycle (PNC), which interconverts IMP and AMP to regulate the nucleotide levels in various tissues, and which contributes to glycolysis and ammoniagenesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. http://togogenome.org/gene/13616:LOC100015002 ^@ http://purl.uniprot.org/uniprot/F6TF65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ETFB ^@ http://purl.uniprot.org/uniprot/F6RMX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/13616:SFTPC ^@ http://purl.uniprot.org/uniprot/F7BJX5 ^@ Function|||Subcellular Location Annotation ^@ Pulmonary surfactant associated proteins promote alveolar stability by lowering the surface tension at the air-liquid interface in the peripheral air spaces.|||surface film http://togogenome.org/gene/13616:LOC100617165 ^@ http://purl.uniprot.org/uniprot/K7E665 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cathelicidin family.|||Secreted http://togogenome.org/gene/13616:CCDC130 ^@ http://purl.uniprot.org/uniprot/F7G340 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/13616:DPYSL5 ^@ http://purl.uniprot.org/uniprot/F6ZT50 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/13616:MMP16 ^@ http://purl.uniprot.org/uniprot/F7G8Z6 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:PRKCD ^@ http://purl.uniprot.org/uniprot/F7D467 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/13616:ODF2 ^@ http://purl.uniprot.org/uniprot/F7FEG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/13616:HMMR ^@ http://purl.uniprot.org/uniprot/A0A5F8HEW4 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/13616:AKAP3 ^@ http://purl.uniprot.org/uniprot/F6PWU5 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/13616:LSM2 ^@ http://purl.uniprot.org/uniprot/F7BWI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/13616:PIH1D1 ^@ http://purl.uniprot.org/uniprot/F6QPU7 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/13616:MPP7 ^@ http://purl.uniprot.org/uniprot/F7DJR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/13616:LOC100017586 ^@ http://purl.uniprot.org/uniprot/F6RBR7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:EGFLAM ^@ http://purl.uniprot.org/uniprot/F7FWY4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RPS28 ^@ http://purl.uniprot.org/uniprot/F7D8M7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/13616:LOC100032592 ^@ http://purl.uniprot.org/uniprot/F7G5F8 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:GRHL2 ^@ http://purl.uniprot.org/uniprot/F7FSL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RPS20 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPJ3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Component of the 40S small ribosomal subunit. http://togogenome.org/gene/13616:MUT ^@ http://purl.uniprot.org/uniprot/F7DW04 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/13616:ARL4D ^@ http://purl.uniprot.org/uniprot/F6S4U6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/13616:LOC100012003 ^@ http://purl.uniprot.org/uniprot/F7A5I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/F6XCN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/13616:TMEM263 ^@ http://purl.uniprot.org/uniprot/F7BB95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/13616:CHRNA3 ^@ http://purl.uniprot.org/uniprot/F7G2L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:AEBP1 ^@ http://purl.uniprot.org/uniprot/F7G8P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Secreted http://togogenome.org/gene/13616:TBRG1 ^@ http://purl.uniprot.org/uniprot/F7FAF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TBPL1 ^@ http://purl.uniprot.org/uniprot/F7F0J5 ^@ Similarity|||Subunit ^@ Belongs to the TBP family.|||Binds TFIIA and TFIIB. http://togogenome.org/gene/13616:PDYN ^@ http://purl.uniprot.org/uniprot/F6RT62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/13616:LOC100027785 ^@ http://purl.uniprot.org/uniprot/F6SWT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/13616:NEK9 ^@ http://purl.uniprot.org/uniprot/F6SL97 ^@ Similarity ^@ Belongs to the protein kinase superfamily. NEK Ser/Thr protein kinase family. NIMA subfamily. http://togogenome.org/gene/13616:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJJ1|||http://purl.uniprot.org/uniprot/A0A5F8GW74|||http://purl.uniprot.org/uniprot/F7FUN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/13616:DKC1 ^@ http://purl.uniprot.org/uniprot/F7EDM7 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/13616:LOC100022644 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100020394 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FLVCR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HI92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPS6 ^@ http://purl.uniprot.org/uniprot/F6VVN3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/13616:SAP18 ^@ http://purl.uniprot.org/uniprot/F6YIF1 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/13616:RPIA ^@ http://purl.uniprot.org/uniprot/F6QSF2 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/13616:LOC100024081 ^@ http://purl.uniprot.org/uniprot/F7EHZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RIF1 ^@ http://purl.uniprot.org/uniprot/F7FA78|||http://purl.uniprot.org/uniprot/K7E160 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/13616:FGF12 ^@ http://purl.uniprot.org/uniprot/F7ELZ5 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/13616:MAP3K5 ^@ http://purl.uniprot.org/uniprot/F6UTB5|||http://purl.uniprot.org/uniprot/F6ZUM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/13616:ENTPD4 ^@ http://purl.uniprot.org/uniprot/F7FVT0 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/13616:DHDDS ^@ http://purl.uniprot.org/uniprot/F6Y1P6 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/13616:CMC2 ^@ http://purl.uniprot.org/uniprot/F7G3E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/13616:RHBDD3 ^@ http://purl.uniprot.org/uniprot/F6PH35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:EIF2A ^@ http://purl.uniprot.org/uniprot/F6T2J6 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/13616:ESCO1 ^@ http://purl.uniprot.org/uniprot/F7G2W9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100011081 ^@ http://purl.uniprot.org/uniprot/F6QVF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PRKAB1 ^@ http://purl.uniprot.org/uniprot/F6TML6 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/13616:OLFM1 ^@ http://purl.uniprot.org/uniprot/F7EDF9|||http://purl.uniprot.org/uniprot/F7EDG3 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/13616:FCER1G ^@ http://purl.uniprot.org/uniprot/F7F5Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100021126 ^@ http://purl.uniprot.org/uniprot/F6RN91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MTRF1 ^@ http://purl.uniprot.org/uniprot/F7G763 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/13616:OPN3 ^@ http://purl.uniprot.org/uniprot/F6RGC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/13616:LOC100027341 ^@ http://purl.uniprot.org/uniprot/F7GHV8 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/13616:LOC100010148 ^@ http://purl.uniprot.org/uniprot/F7E232 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:C4HXorf23 ^@ http://purl.uniprot.org/uniprot/A0A5F8GIB8|||http://purl.uniprot.org/uniprot/A0A5F8GMU8|||http://purl.uniprot.org/uniprot/A0A5F8GRQ6|||http://purl.uniprot.org/uniprot/A0A5F8H0A3|||http://purl.uniprot.org/uniprot/F7E4Z7 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/13616:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/F6QTD0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/13616:EDN3 ^@ http://purl.uniprot.org/uniprot/F6ZC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endothelin/sarafotoxin family.|||Secreted http://togogenome.org/gene/13616:ELMO3 ^@ http://purl.uniprot.org/uniprot/F7E1P5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/13616:USP49 ^@ http://purl.uniprot.org/uniprot/F7DCJ7 ^@ Function|||Similarity ^@ Belongs to the peptidase C19 family.|||Deubiquitinating enzyme that removes conjugated ubiquitin from specific proteins to regulate different cellular processes. http://togogenome.org/gene/13616:TMEM38B ^@ http://purl.uniprot.org/uniprot/F6YNW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/13616:ATP6V1F ^@ http://purl.uniprot.org/uniprot/A0A5F8GU20 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/13616:monDomV1R1275 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MDFI ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ01 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/13616:DLGAP3 ^@ http://purl.uniprot.org/uniprot/F6TSK1 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/13616:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:CCNA1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSX8|||http://purl.uniprot.org/uniprot/A0A5F8H3Q9|||http://purl.uniprot.org/uniprot/F6USE6 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin AB subfamily. http://togogenome.org/gene/13616:LOC100010127 ^@ http://purl.uniprot.org/uniprot/F6REK2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:monDomV1R1235 ^@ http://purl.uniprot.org/uniprot/F7AKA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CALR3 ^@ http://purl.uniprot.org/uniprot/F7FVR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calreticulin family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3A1|||http://purl.uniprot.org/uniprot/A0A5F8H884|||http://purl.uniprot.org/uniprot/F7B938 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Golgi stack membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. Homodimer.|||trans-Golgi network membrane http://togogenome.org/gene/13616:EN2 ^@ http://purl.uniprot.org/uniprot/F7FKY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Engrailed homeobox family.|||Nucleus http://togogenome.org/gene/13616:DDX41 ^@ http://purl.uniprot.org/uniprot/F6QGJ3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX41 subfamily. http://togogenome.org/gene/13616:SLC18A2 ^@ http://purl.uniprot.org/uniprot/F7BLF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Vesicular transporter family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/13616:HYI ^@ http://purl.uniprot.org/uniprot/F6YYI5 ^@ Function|||Similarity ^@ Belongs to the hyi family.|||Catalyzes the reversible isomerization between hydroxypyruvate and 2-hydroxy-3-oxopropanoate (also termed tartronate semialdehyde). http://togogenome.org/gene/13616:KCNC4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY55|||http://purl.uniprot.org/uniprot/F6XGB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100027795 ^@ http://purl.uniprot.org/uniprot/F7G8K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SEC11C ^@ http://purl.uniprot.org/uniprot/F7ARM9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:YWHAG ^@ http://purl.uniprot.org/uniprot/F6TY10 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:TYSND1 ^@ http://purl.uniprot.org/uniprot/F7CEH3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1B family.|||Peroxisomal protease that mediates both the removal of the leader peptide from proteins containing a PTS2 target sequence and processes several PTS1-containing proteins. Catalyzes the processing of PTS1-proteins involved in the peroxisomal beta-oxidation of fatty acids.|||Peroxisome|||The full-lengh TYSND1 is the active the proteolytic processing of PTS1- and PTS2-proteins and in self-cleavage, and intermolecular self-cleavage of TYSND1 down-regulates its protease activity. http://togogenome.org/gene/13616:POP4 ^@ http://purl.uniprot.org/uniprot/K7DZP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/13616:SRXN1 ^@ http://purl.uniprot.org/uniprot/F6VCF5 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/13616:SDPR ^@ http://purl.uniprot.org/uniprot/F7G2V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/13616:PFDN6 ^@ http://purl.uniprot.org/uniprot/F6TRF6 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/13616:GPR34 ^@ http://purl.uniprot.org/uniprot/F7ENK9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:VN2R514 ^@ http://purl.uniprot.org/uniprot/F6PP39 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:STOML3 ^@ http://purl.uniprot.org/uniprot/F6SAG4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/13616:LOC103103098 ^@ http://purl.uniprot.org/uniprot/K7E3D5 ^@ Similarity ^@ Belongs to the SLAIN motif-containing family. http://togogenome.org/gene/13616:monDomV1R1253 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TJP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY42 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:TAGLN ^@ http://purl.uniprot.org/uniprot/F6X7N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calponin family.|||Cytoplasm http://togogenome.org/gene/13616:WEE1 ^@ http://purl.uniprot.org/uniprot/F7G957 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/13616:GATSL3 ^@ http://purl.uniprot.org/uniprot/F7DVY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GATS family.|||cytosol http://togogenome.org/gene/13616:MID1 ^@ http://purl.uniprot.org/uniprot/F6SKS1 ^@ Function|||Subcellular Location Annotation ^@ Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||cytoskeleton http://togogenome.org/gene/13616:PM20D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GBU6 ^@ Function|||Similarity ^@ Belongs to the peptidase M20A family.|||Catalyzes the peptide bond hydrolysis in dipeptides having basic amino acids lysine, ornithine or arginine at C-terminus. http://togogenome.org/gene/13616:SNX19 ^@ http://purl.uniprot.org/uniprot/A0A5F8H366 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/13616:RPS17 ^@ http://purl.uniprot.org/uniprot/F6QXP9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/13616:LOC100009985 ^@ http://purl.uniprot.org/uniprot/F6Y2P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/13616:BIRC7 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG31 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/13616:PIH1D2 ^@ http://purl.uniprot.org/uniprot/F7C283 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/13616:TRMT2A ^@ http://purl.uniprot.org/uniprot/F6S9Y2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:monDomV1R1269 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SLC5A5 ^@ http://purl.uniprot.org/uniprot/K7E2A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:STXBP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLR2|||http://purl.uniprot.org/uniprot/F6XL12 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/13616:P3H3 ^@ http://purl.uniprot.org/uniprot/F7CXE1 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/13616:TEKT5 ^@ http://purl.uniprot.org/uniprot/F7GGX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||Microtubule inner protein (MIP) part of the dynein-decorated doublet microtubules (DMTs) in cilia and flagellar axoneme. Forms filamentous polymers in the walls of ciliary and flagellar microtubules. Required for normal sperm mobility.|||flagellum http://togogenome.org/gene/13616:LOC100024733 ^@ http://purl.uniprot.org/uniprot/A0A5F8H4V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100010371 ^@ http://purl.uniprot.org/uniprot/A0A5F8H332 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SPIRE2 ^@ http://purl.uniprot.org/uniprot/F7DX14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/13616:LOC100030124 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVV4 ^@ Similarity ^@ Belongs to the GST superfamily. Mu family. http://togogenome.org/gene/13616:FOXA2 ^@ http://purl.uniprot.org/uniprot/F7FSC5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TOR1A ^@ http://purl.uniprot.org/uniprot/F6PGK6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum lumen|||Homohexamer. Interacts with TOR1B; the interaction may be specific of neural tissues. Interacts (ATP-bound) with TOR1AIP1 and TOR1AIP2; the interactions induce ATPase activity. Interacts with KLHL14; preferentially when ATP-free. Interacts with KLC1 (via TPR repeats); the interaction associates TOR1A with the kinesin oligomeric complex. Interacts with COPS4; the interaction associates TOR1A with the CSN complex. Interacts with SNAPIN; the interaction is direct and associates SNAPIN with the CSN complex. Interacts with STON2. Interacts (ATP-bound) with SYNE3 (via KASH domain); the interaction is required for SYNE3 nuclear envelope localization. Interacts with VIM; the interaction associates TOR1A with the cytoskeleton. Interacts with PLEC. Interacts (ATP-bound) with SLC6A3; regulates SLC6A3 transport to the plasma membrane.|||Membrane|||growth cone http://togogenome.org/gene/13616:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HKS1|||http://purl.uniprot.org/uniprot/F6Q3T2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:TSPAN2 ^@ http://purl.uniprot.org/uniprot/F6ULW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:NUDT1 ^@ http://purl.uniprot.org/uniprot/F7FR03 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/13616:UMOD ^@ http://purl.uniprot.org/uniprot/F7CX48 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Cell membrane|||In the urine, may contribute to colloid osmotic pressure, retards passage of positively charged electrolytes, prevents urinary tract infection and inhibits formation of liquid containing supersaturated salts and subsequent formation of salt crystals.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||cilium membrane http://togogenome.org/gene/13616:PTPN4 ^@ http://purl.uniprot.org/uniprot/F6VU58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||May act at junctions between the membrane and the cytoskeleton.|||cytoskeleton http://togogenome.org/gene/13616:GDI1 ^@ http://purl.uniprot.org/uniprot/F6QUY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Regulates the GDP/GTP exchange reaction of most RAB proteins by inhibiting the dissociation of GDP from them, and the subsequent binding of GTP. http://togogenome.org/gene/13616:FAM120B ^@ http://purl.uniprot.org/uniprot/A0A5F8G7V9 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/13616:MODO-UJ ^@ http://purl.uniprot.org/uniprot/A0A5F8H0S5|||http://purl.uniprot.org/uniprot/C6ZIV6 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:GPAT4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPC8|||http://purl.uniprot.org/uniprot/F7F7R1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/13616:FAM192A ^@ http://purl.uniprot.org/uniprot/F6WK12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:RNF167 ^@ http://purl.uniprot.org/uniprot/F7D206 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100023660 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/13616:CWC15 ^@ http://purl.uniprot.org/uniprot/F6XA31 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/13616:TCF7L2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZI9|||http://purl.uniprot.org/uniprot/F6WN21 ^@ Similarity ^@ Belongs to the TCF/LEF family. http://togogenome.org/gene/13616:TSN ^@ http://purl.uniprot.org/uniprot/F6XTG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the translin family.|||DNA-binding protein that specifically recognizes consensus sequences at the breakpoint junctions in chromosomal translocations, mostly involving immunoglobulin (Ig)/T-cell receptor gene segments. Seems to recognize single-stranded DNA ends generated by staggered breaks occurring at recombination hot spots.|||Exhibits both single-stranded and double-stranded endoribonuclease activity. May act as an activator of RNA-induced silencing complex (RISC) by facilitating endonucleolytic cleavage of the siRNA passenger strand.|||Nucleus|||Ring-shaped heterooctamer of six TSN and two TSNAX subunits, DNA/RNA binding occurs inside the ring. http://togogenome.org/gene/13616:NDUFB6 ^@ http://purl.uniprot.org/uniprot/F6QJJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:SNX8 ^@ http://purl.uniprot.org/uniprot/F6WT78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/13616:TM6SF1 ^@ http://purl.uniprot.org/uniprot/F6WSJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100028751 ^@ http://purl.uniprot.org/uniprot/F7FSM7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC103099050 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6J1 ^@ Similarity ^@ Belongs to the peptidase S51 family. http://togogenome.org/gene/13616:PHC2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GER8|||http://purl.uniprot.org/uniprot/F6U443 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SGIP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GA96 ^@ Function|||Subcellular Location Annotation ^@ May function in clathrin-mediated endocytosis. Has both a membrane binding/tubulating activity and the ability to recruit proteins essential to the formation of functional clathrin-coated pits. Has a preference for membranes enriched in phosphatidylserine and phosphoinositides and is required for the endocytosis of the transferrin receptor. May also bind tubulin. May play a role in the regulation of energy homeostasis.|||clathrin-coated pit http://togogenome.org/gene/13616:C6H16orf72 ^@ http://purl.uniprot.org/uniprot/F6YKN0 ^@ Similarity ^@ Belongs to the TAPR1 family. http://togogenome.org/gene/13616:MYO6 ^@ http://purl.uniprot.org/uniprot/F7BRQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||clathrin-coated pit|||clathrin-coated vesicle|||filopodium|||microvillus http://togogenome.org/gene/13616:FRZB ^@ http://purl.uniprot.org/uniprot/F7DR48 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/13616:HOXB2 ^@ http://purl.uniprot.org/uniprot/F7E227 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ATF7IP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQX1|||http://purl.uniprot.org/uniprot/F7E6T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCAF family.|||Nucleus http://togogenome.org/gene/13616:LOC100026304 ^@ http://purl.uniprot.org/uniprot/F7DJJ8 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/13616:SLC1A4 ^@ http://purl.uniprot.org/uniprot/F7DYZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/13616:FAM198B ^@ http://purl.uniprot.org/uniprot/F6VJU0 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/13616:LOC100021085 ^@ http://purl.uniprot.org/uniprot/F6U1C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/13616:DSP ^@ http://purl.uniprot.org/uniprot/F6Y796 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:LOC100029120 ^@ http://purl.uniprot.org/uniprot/F7GIB9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/13616:LOC100618631 ^@ http://purl.uniprot.org/uniprot/F7GEE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103094472 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6I3|||http://purl.uniprot.org/uniprot/K7E5T1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PALM3 ^@ http://purl.uniprot.org/uniprot/F7G546 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/13616:CDK5RAP3 ^@ http://purl.uniprot.org/uniprot/F6PJH2 ^@ Similarity ^@ Belongs to the CDK5RAP3 family. http://togogenome.org/gene/13616:ATRAID ^@ http://purl.uniprot.org/uniprot/A0A5F8HHE5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:AMOTL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCJ2|||http://purl.uniprot.org/uniprot/F6TGA6 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/13616:DBT ^@ http://purl.uniprot.org/uniprot/A0A5F8GUX4|||http://purl.uniprot.org/uniprot/F7FPX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Mitochondrion matrix http://togogenome.org/gene/13616:RP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG37|||http://purl.uniprot.org/uniprot/F6USG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a GTPase-activating protein (GAP) for tubulin in concert with tubulin-specific chaperone C, but does not enhance tubulin heterodimerization.|||Belongs to the TBCC family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100018186 ^@ http://purl.uniprot.org/uniprot/A0A5F8HIS7|||http://purl.uniprot.org/uniprot/F7C7X8 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/13616:SH3BP4 ^@ http://purl.uniprot.org/uniprot/F7E2A9 ^@ Subcellular Location Annotation ^@ Nucleus|||Vesicle|||clathrin-coated pit|||clathrin-coated vesicle http://togogenome.org/gene/13616:CHAF1A ^@ http://purl.uniprot.org/uniprot/F7F7P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHAF1A family.|||Nucleus http://togogenome.org/gene/13616:OXCT1 ^@ http://purl.uniprot.org/uniprot/F7C0D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate.|||Mitochondrion http://togogenome.org/gene/13616:SLC37A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL56|||http://purl.uniprot.org/uniprot/A0A5F8H1L5|||http://purl.uniprot.org/uniprot/F6QNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/13616:REM2 ^@ http://purl.uniprot.org/uniprot/F7A1Z3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/13616:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSL7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/13616:HOXA6 ^@ http://purl.uniprot.org/uniprot/F6UAS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:GYS2 ^@ http://purl.uniprot.org/uniprot/F7CFJ9 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/13616:CALY ^@ http://purl.uniprot.org/uniprot/F7ES78 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/13616:LOC100025736 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYG9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/13616:MAP6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STOP family.|||cytoskeleton http://togogenome.org/gene/13616:PGGT1B ^@ http://purl.uniprot.org/uniprot/A0A5F8HJM0 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/13616:LOC100014048 ^@ http://purl.uniprot.org/uniprot/F6W3D7 ^@ Similarity ^@ Belongs to the histone H3 family. http://togogenome.org/gene/13616:SULT4A1 ^@ http://purl.uniprot.org/uniprot/F7FS04 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/13616:ZFP36L2 ^@ http://purl.uniprot.org/uniprot/F6QMJ3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the cytoplasmic CCR4-NOT deadenylase complex to trigger ARE-containing mRNA deadenylation and decay processes.|||Cytoplasm|||Nucleus|||Zinc-finger RNA-binding protein that destabilizes several cytoplasmic AU-rich element (ARE)-containing mRNA transcripts by promoting their poly(A) tail removal or deadenylation, and hence provide a mechanism for attenuating protein synthesis. Acts as a 3'-untranslated region (UTR) ARE mRNA-binding adapter protein to communicate signaling events to the mRNA decay machinery. Functions by recruiting the CCR4-NOT deadenylase complex and probably other components of the cytoplasmic RNA decay machinery to the bound ARE-containing mRNAs, and hence promotes ARE-mediated mRNA deadenylation and decay processes. Binds to 3'-UTR ARE of numerous mRNAs. http://togogenome.org/gene/13616:RHBDL1 ^@ http://purl.uniprot.org/uniprot/F7BYT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:TM9SF3 ^@ http://purl.uniprot.org/uniprot/F6UNN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/13616:monDomV1R1270 ^@ http://purl.uniprot.org/uniprot/A0A5F8H371 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DUSP16 ^@ http://purl.uniprot.org/uniprot/F6PGB7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/13616:NOP10 ^@ http://purl.uniprot.org/uniprot/F7DQA8 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/13616:CDK8 ^@ http://purl.uniprot.org/uniprot/F6TLP1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:KCNK3 ^@ http://purl.uniprot.org/uniprot/F6ZSC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:HCN3 ^@ http://purl.uniprot.org/uniprot/F6XHS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel HCN family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC103094747 ^@ http://purl.uniprot.org/uniprot/K7E641 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:CCNB3 ^@ http://purl.uniprot.org/uniprot/F6RLN2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/13616:LOC100619142 ^@ http://purl.uniprot.org/uniprot/F6QSK9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:EGFR ^@ http://purl.uniprot.org/uniprot/F7B2I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/13616:MC3R ^@ http://purl.uniprot.org/uniprot/F6XQW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/13616:CENPJ ^@ http://purl.uniprot.org/uniprot/F7EBI9 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/13616:S100G ^@ http://purl.uniprot.org/uniprot/F6XYL1 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/13616:DBR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lariat debranching enzyme family.|||Nucleus http://togogenome.org/gene/13616:LOC100030366 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100028856 ^@ http://purl.uniprot.org/uniprot/F7EVQ1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:FAM229B ^@ http://purl.uniprot.org/uniprot/F7GFM1 ^@ Similarity ^@ Belongs to the FAM229 family. http://togogenome.org/gene/13616:XCR1 ^@ http://purl.uniprot.org/uniprot/F7E7R3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LOC100030460 ^@ http://purl.uniprot.org/uniprot/F6SHD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:BECN1 ^@ http://purl.uniprot.org/uniprot/F7FHK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Beclin-1-C 35 kDa localized to mitochondria can promote apoptosis; it induces the mitochondrial translocation of BAX and the release of proapoptotic factors.|||Belongs to the beclin family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Endosome membrane|||Membrane|||Mitochondrion membrane|||Plays a central role in autophagy.|||autophagosome|||trans-Golgi network membrane http://togogenome.org/gene/13616:EFNA4 ^@ http://purl.uniprot.org/uniprot/F6UJJ3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MDFIC ^@ http://purl.uniprot.org/uniprot/F7F0D0 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/13616:CLDN17 ^@ http://purl.uniprot.org/uniprot/F6ZAA7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:SERPINI1 ^@ http://purl.uniprot.org/uniprot/F7FLY6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:HMGN3 ^@ http://purl.uniprot.org/uniprot/F6XTZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Binds to nucleosomes, regulating chromatin structure and consequently, chromatin-dependent processes such as transcription, DNA replication and DNA repair. Affects both insulin and glucagon levels and modulates the expression of pancreatic genes involved in insulin secretion. Regulates the expression of the glucose transporter SLC2A2 by binding specifically to its promoter region and recruiting PDX1 and additional transcription factors. Regulates the expression of SLC6A9, a glycine transporter which regulates the glycine concentration in synaptic junctions in the central nervous system, by binding to its transcription start site. May play a role in ocular development and astrocyte function.|||Nucleus http://togogenome.org/gene/13616:CTNNBL1 ^@ http://purl.uniprot.org/uniprot/F6SZ07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100028680 ^@ http://purl.uniprot.org/uniprot/F6RLC1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:FAM69C ^@ http://purl.uniprot.org/uniprot/F7DHI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/13616:RSBN1 ^@ http://purl.uniprot.org/uniprot/F6VPY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/13616:LHX4 ^@ http://purl.uniprot.org/uniprot/F7GCT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SSBP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5R3|||http://purl.uniprot.org/uniprot/A0A5F8HAG3|||http://purl.uniprot.org/uniprot/F7CJK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:VPS16 ^@ http://purl.uniprot.org/uniprot/F6YLL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS16 family.|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||Vesicle http://togogenome.org/gene/13616:LOC100024720 ^@ http://purl.uniprot.org/uniprot/F7BPG0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:HBEGF ^@ http://purl.uniprot.org/uniprot/F7G3R4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PCK2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXQ3 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/13616:CDCA5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKL1|||http://purl.uniprot.org/uniprot/A0A5F8HHF3 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/13616:IAH1 ^@ http://purl.uniprot.org/uniprot/F7EU63 ^@ Function|||Similarity ^@ Belongs to the 'GDSL' lipolytic enzyme family. IAH1 subfamily.|||Probable lipase. http://togogenome.org/gene/13616:EPHA3 ^@ http://purl.uniprot.org/uniprot/F6UM70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ADRB1 ^@ http://purl.uniprot.org/uniprot/F6WB19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100010923 ^@ http://purl.uniprot.org/uniprot/A0A5F8H3Q7 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/13616:C2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8R9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Component C2 which is part of the classical pathway of the complement system is cleaved by activated factor C1 into two fragments: C2b and C2a. C2a, a serine protease, then combines with complement factor C4b to generate the C3 or C5 convertase.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:NEFL ^@ http://purl.uniprot.org/uniprot/F6S064 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intermediate filament family.|||cytoskeleton http://togogenome.org/gene/13616:LOC100023494 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:MTHFD1 ^@ http://purl.uniprot.org/uniprot/F7BG84 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/13616:SLC41A2 ^@ http://purl.uniprot.org/uniprot/F6UGU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/13616:GLRA2 ^@ http://purl.uniprot.org/uniprot/F6SLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC100025494 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDN9 ^@ Similarity|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family.|||Homodimer. http://togogenome.org/gene/13616:LOC103103310 ^@ http://purl.uniprot.org/uniprot/F6XQY4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:F9 ^@ http://purl.uniprot.org/uniprot/F6VQC9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Factor IX is a vitamin K-dependent plasma protein that participates in the intrinsic pathway of blood coagulation by converting factor X to its active form in the presence of Ca(2+) ions, phospholipids, and factor VIIIa.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:SORD ^@ http://purl.uniprot.org/uniprot/F7GFN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Mitochondrion membrane|||flagellum http://togogenome.org/gene/13616:LOC100028958 ^@ http://purl.uniprot.org/uniprot/F7ALP1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:RSBN1L ^@ http://purl.uniprot.org/uniprot/F6QE29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the round spermatid basic protein 1 family.|||Nucleus http://togogenome.org/gene/13616:CDH10 ^@ http://purl.uniprot.org/uniprot/A0A5F8G4P3|||http://purl.uniprot.org/uniprot/F7BIQ7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GDPD3 ^@ http://purl.uniprot.org/uniprot/F7EHS7 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/13616:SLC22A3 ^@ http://purl.uniprot.org/uniprot/F7BTT8 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/13616:LOC100618060 ^@ http://purl.uniprot.org/uniprot/F7GIG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100619950 ^@ http://purl.uniprot.org/uniprot/F7F0W8 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/13616:LOC100010091 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMM8 ^@ Similarity ^@ Belongs to the sepiapterin reductase family. http://togogenome.org/gene/13616:C7 ^@ http://purl.uniprot.org/uniprot/F7BFI5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:CXCL9 ^@ http://purl.uniprot.org/uniprot/K7DZR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/13616:LOC100021555 ^@ http://purl.uniprot.org/uniprot/F6V553 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/13616:UTP11 ^@ http://purl.uniprot.org/uniprot/F7FHI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/13616:PTX4 ^@ http://purl.uniprot.org/uniprot/F7G8Q0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:NFXL1 ^@ http://purl.uniprot.org/uniprot/F6ZAS3 ^@ Similarity ^@ Belongs to the NFX1 family. http://togogenome.org/gene/13616:CCNC ^@ http://purl.uniprot.org/uniprot/F7FG42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. Binds to and activates cyclin-dependent kinase CDK8 that phosphorylates the CTD (C-terminal domain) of the large subunit of RNA polymerase II (RNAp II), which may inhibit the formation of a transcription initiation complex.|||Nucleus http://togogenome.org/gene/13616:FAT4 ^@ http://purl.uniprot.org/uniprot/F7DA88 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100021678 ^@ http://purl.uniprot.org/uniprot/F7EQ32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/13616:MARS2 ^@ http://purl.uniprot.org/uniprot/F6PRC1 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H7K5|||http://purl.uniprot.org/uniprot/F6RFE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FAM160B1 ^@ http://purl.uniprot.org/uniprot/F6XT73 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/13616:TMED2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GH98|||http://purl.uniprot.org/uniprot/A0A5F8GS26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/13616:EMC9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HG77 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/13616:DBX2 ^@ http://purl.uniprot.org/uniprot/F7GL38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100010939 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome. Pericentriolar matrix component that regulates alpha/beta chain minus-end nucleation, centrosome duplication and spindle formation.|||centrosome http://togogenome.org/gene/13616:NIPSNAP3A ^@ http://purl.uniprot.org/uniprot/F7C1W8 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/13616:MARCKSL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H539 ^@ Similarity ^@ Belongs to the MARCKS family. http://togogenome.org/gene/13616:LOC100023114 ^@ http://purl.uniprot.org/uniprot/F7DGD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:ILDR1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H798|||http://purl.uniprot.org/uniprot/F6PWR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/13616:CSNK2A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G710 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:PDGFRL ^@ http://purl.uniprot.org/uniprot/F7AYD0 ^@ Subcellular Location Annotation|||Subunit ^@ Forms a complex composed of PDGFRL, TNK2 and GRB2.|||Secreted http://togogenome.org/gene/13616:CSTF1 ^@ http://purl.uniprot.org/uniprot/F7ARW5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CER1 ^@ http://purl.uniprot.org/uniprot/F7CG49 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:GTF2H5 ^@ http://purl.uniprot.org/uniprot/F7FNG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/13616:SLC4A3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GHW9|||http://purl.uniprot.org/uniprot/F7G5B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/13616:LOC100028999 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LAMP1 ^@ http://purl.uniprot.org/uniprot/F7D889 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane|||Lysosome membrane http://togogenome.org/gene/13616:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GKA2|||http://purl.uniprot.org/uniprot/A0A5F8GTP8|||http://purl.uniprot.org/uniprot/A0A5F8GWZ2|||http://purl.uniprot.org/uniprot/A0A5F8H5G5 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/13616:ANGPTL4 ^@ http://purl.uniprot.org/uniprot/F7D756 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/13616:IMMP1L ^@ http://purl.uniprot.org/uniprot/F7AX03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Catalyzes the removal of transit peptides required for the targeting of proteins from the mitochondrial matrix, across the inner membrane, into the inter-membrane space. Known to process the nuclear encoded protein DIABLO.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:LARS2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDF7|||http://purl.uniprot.org/uniprot/F6WJ64 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:IDO2 ^@ http://purl.uniprot.org/uniprot/B3Y9H9 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/13616:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A5F8HET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/13616:SPPL2A ^@ http://purl.uniprot.org/uniprot/A0A5F8H1Y2|||http://purl.uniprot.org/uniprot/A0A5F8HAT2|||http://purl.uniprot.org/uniprot/F6YF27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/13616:TNK2 ^@ http://purl.uniprot.org/uniprot/F6XU33 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/13616:monDomV1R1268 ^@ http://purl.uniprot.org/uniprot/F6Z456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:YWHAH ^@ http://purl.uniprot.org/uniprot/F6WA79 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/13616:WDR4 ^@ http://purl.uniprot.org/uniprot/F6QYZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat TRM82 family.|||Forms a heterodimer with the catalytic subunit METTL1.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/13616:ETS1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0C9|||http://purl.uniprot.org/uniprot/F6Y1Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TIMM50 ^@ http://purl.uniprot.org/uniprot/F7AVY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FUNDC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H9F6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FUN14 family.|||Mitochondrion outer membrane http://togogenome.org/gene/13616:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDI8|||http://purl.uniprot.org/uniprot/F7EFL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/13616:CCDC109B ^@ http://purl.uniprot.org/uniprot/A0A5F8G4G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FUT9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBF0|||http://purl.uniprot.org/uniprot/F6U690 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/13616:GDA ^@ http://purl.uniprot.org/uniprot/F7DIF8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/13616:YKT6 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/13616:LOC100027731 ^@ http://purl.uniprot.org/uniprot/F7GCD4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:EMC8 ^@ http://purl.uniprot.org/uniprot/F6QIS0 ^@ Similarity ^@ Belongs to the EMC8/EMC9 family. http://togogenome.org/gene/13616:CEP76 ^@ http://purl.uniprot.org/uniprot/K7E5R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/13616:HSD17B2 ^@ http://purl.uniprot.org/uniprot/F7CF43 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:MTTP ^@ http://purl.uniprot.org/uniprot/F7BAZ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VGLL3 ^@ http://purl.uniprot.org/uniprot/F6VMX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/13616:FGF2 ^@ http://purl.uniprot.org/uniprot/P48798 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for FGFR1, FGFR2, FGFR3 and FGFR4 (By similarity). Also acts as an integrin ligand which is required for FGF2 signaling (By similarity). Binds to integrin ITGAV:ITGB3 (By similarity). Plays an important role in the regulation of cell survival, cell division, cell differentiation and cell migration (By similarity). Functions as a potent mitogen in vitro. Can induce angiogenesis (By similarity). Mediates phosphorylation of ERK1/2 and thereby promotes retinal lens fiber differentiation (By similarity).|||Belongs to the heparin-binding growth factors family.|||Monomer. Homodimer. Interacts with FGFR1, FGFR2, FGFR3 and FGFR4. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors. Interacts with CSPG4, FGFBP1 and TEC. Found in a complex with FGFBP1, FGF1 and FGF2. Interacts with FGFBP3. Interacts with integrin ITGAV:ITGB3; the interaction is required for FGF2 signaling. Interacts with SNORC (via the extracellular domain). Interacts with glypican GPC3.|||Nucleus|||Phosphorylation at Tyr-83 regulates FGF2 unconventional secretion.|||Secreted http://togogenome.org/gene/13616:ATP2B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G500|||http://purl.uniprot.org/uniprot/A0A5F8GWQ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lateral cell membrane|||Membrane|||Presynaptic cell membrane|||Synaptic cell membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:SDHC ^@ http://purl.uniprot.org/uniprot/F7EQW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b560 family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). http://togogenome.org/gene/13616:ACP1 ^@ http://purl.uniprot.org/uniprot/F7G3D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on tyrosine phosphorylated proteins, low-MW aryl phosphates and natural and synthetic acyl phosphates.|||Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/13616:GABRR1 ^@ http://purl.uniprot.org/uniprot/F6Q6H4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:RTN2 ^@ http://purl.uniprot.org/uniprot/F6WV31 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:DTD1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2N0|||http://purl.uniprot.org/uniprot/F6UKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/13616:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/13616:LIG3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H947|||http://purl.uniprot.org/uniprot/F7EC71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/13616:APIP ^@ http://purl.uniprot.org/uniprot/A0A5F8GU04 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway, which plays a key role in cancer, apoptosis, microbial proliferation and inflammation. May inhibit the CASP1-related inflammatory response (pyroptosis), the CASP9-dependent apoptotic pathway and the cytochrome c-dependent and APAF1-mediated cell death.|||Cytoplasm|||Homotetramer. Interacts with APAF1. May interact with CASP1. http://togogenome.org/gene/13616:FAM134B ^@ http://purl.uniprot.org/uniprot/A0A5F8G5W0|||http://purl.uniprot.org/uniprot/A0A5F8G7J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/13616:CNN1 ^@ http://purl.uniprot.org/uniprot/F7FFG1 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/13616:TSPAN5 ^@ http://purl.uniprot.org/uniprot/F7BAB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/13616:ESYT3 ^@ http://purl.uniprot.org/uniprot/F7FRN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the extended synaptotagmin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/13616:T2R3F ^@ http://purl.uniprot.org/uniprot/Q2ABA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:HDAC8 ^@ http://purl.uniprot.org/uniprot/F6SGB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility. In addition to protein deacetylase activity, also has protein-lysine deacylase activity: acts as a protein decrotonylase by mediating decrotonylation ((2E)-butenoyl) of histones.|||Nucleus http://togogenome.org/gene/13616:LOC100022327 ^@ http://purl.uniprot.org/uniprot/F7B5I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100030299 ^@ http://purl.uniprot.org/uniprot/F7CGP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RPS14 ^@ http://purl.uniprot.org/uniprot/F7FN91 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/13616:OTULIN ^@ http://purl.uniprot.org/uniprot/F6PM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/13616:monDomV1R1243 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SNRNP200 ^@ http://purl.uniprot.org/uniprot/F7G4E6 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/13616:LOC100013421 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:RPL13A ^@ http://purl.uniprot.org/uniprot/F6TPW7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/13616:SLC9C1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQV9 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/13616:LSM6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/13616:T2R26 ^@ http://purl.uniprot.org/uniprot/Q2AB93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Gustducin-coupled receptor implicated in the perception of bitter compounds in the oral cavity and the gastrointestinal tract. Signals through PLCB2 and the calcium-regulated cation channel TRPM5.|||Membrane http://togogenome.org/gene/13616:CES1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G7D6|||http://purl.uniprot.org/uniprot/F6TPH0 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/13616:CD99 ^@ http://purl.uniprot.org/uniprot/K7E4D1 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/13616:LAMTOR1 ^@ http://purl.uniprot.org/uniprot/F6YJR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR1 family.|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:RPL19 ^@ http://purl.uniprot.org/uniprot/F6UYZ4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/13616:LOC100026427 ^@ http://purl.uniprot.org/uniprot/A0A5F8H172 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/F7EKQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/13616:BCAT1 ^@ http://purl.uniprot.org/uniprot/F7G5B7 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/13616:COQ3 ^@ http://purl.uniprot.org/uniprot/F7F1Z8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/13616:MFN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G366 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/13616:HGS ^@ http://purl.uniprot.org/uniprot/A0A5F8H1Z0|||http://purl.uniprot.org/uniprot/F7EJJ9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane|||Involved in intracellular signal transduction mediated by cytokines and growth factors. When associated with STAM, it suppresses DNA signaling upon stimulation by IL-2 and GM-CSF. Could be a direct effector of PI3-kinase in vesicular pathway via early endosomes and may regulate trafficking to early and late endosomes by recruiting clathrin. May concentrate ubiquitinated receptors within clathrin-coated regions. Involved in down-regulation of receptor tyrosine kinase via multivesicular body (MVBs) when complexed with STAM (ESCRT-0 complex). The ESCRT-0 complex binds ubiquitin and acts as sorting machinery that recognizes ubiquitinated receptors and transfers them to further sequential lysosomal sorting/trafficking processes. May contribute to the efficient recruitment of SMADs to the activin receptor complex. Involved in receptor recycling via its association with the CART complex, a multiprotein complex required for efficient transferrin receptor recycling but not for EGFR degradation.|||multivesicular body membrane http://togogenome.org/gene/13616:PCNA ^@ http://purl.uniprot.org/uniprot/F6TIM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/13616:CPEB1 ^@ http://purl.uniprot.org/uniprot/F6RHI7 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/13616:MEF2D ^@ http://purl.uniprot.org/uniprot/A0A5F8GNZ6|||http://purl.uniprot.org/uniprot/A0A5F8GYJ9|||http://purl.uniprot.org/uniprot/A0A5F8GZI2|||http://purl.uniprot.org/uniprot/F7AJL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:FGF5 ^@ http://purl.uniprot.org/uniprot/F6S897 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heparin-binding growth factors family.|||Interacts with FGFR1 and FGFR2. Affinity between fibroblast growth factors (FGFs) and their receptors is increased by heparan sulfate glycosaminoglycans that function as coreceptors.|||Plays an important role in the regulation of cell proliferation and cell differentiation. Required for normal regulation of the hair growth cycle. Functions as an inhibitor of hair elongation by promoting progression from anagen, the growth phase of the hair follicle, into catagen the apoptosis-induced regression phase.|||Secreted http://togogenome.org/gene/13616:monDomV1R1256 ^@ http://purl.uniprot.org/uniprot/A0A5F8GZT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HF31|||http://purl.uniprot.org/uniprot/F6SNQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/13616:LOC100022175 ^@ http://purl.uniprot.org/uniprot/F6W332 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PDCL2 ^@ http://purl.uniprot.org/uniprot/F7DL69 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/13616:INPP5B ^@ http://purl.uniprot.org/uniprot/F6Y5S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/13616:SHOC2 ^@ http://purl.uniprot.org/uniprot/F6RP97 ^@ Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. http://togogenome.org/gene/13616:LOC100011059 ^@ http://purl.uniprot.org/uniprot/F6W5H0 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/13616:ACO1 ^@ http://purl.uniprot.org/uniprot/F7CLP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.|||Interacts (when associated with the 4Fe-4S) with FBXL5. Interacts with frataxin(81-210).|||cytosol http://togogenome.org/gene/13616:HPS3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5C9|||http://purl.uniprot.org/uniprot/F6T3C1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||Cytoplasm|||Involved in early stages of melanosome biogenesis and maturation. http://togogenome.org/gene/13616:HINT1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFM3 ^@ Similarity ^@ Belongs to the HINT family. http://togogenome.org/gene/13616:LALBA ^@ http://purl.uniprot.org/uniprot/F6QCI9 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 22 family.|||Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N-acetylglucosamine of the oligosaccharide chains in glycoproteins. http://togogenome.org/gene/13616:LOC100018582 ^@ http://purl.uniprot.org/uniprot/F7EGW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FGGY kinase family.|||Cytoplasm http://togogenome.org/gene/13616:SH3BGRL2 ^@ http://purl.uniprot.org/uniprot/K7E2N2 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/13616:LOC100032291 ^@ http://purl.uniprot.org/uniprot/F6RV04 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/13616:EIF3I ^@ http://purl.uniprot.org/uniprot/F7FEZ1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M. The eIF-3 complex appears to include 3 stable modules: module A is composed of EIF3A, EIF3B, EIF3G and EIF3I; module B is composed of EIF3F, EIF3H, and EIF3M; and module C is composed of EIF3C, EIF3D, EIF3E, EIF3K and EIF3L. EIF3C of module C binds EIF3B of module A and EIF3H of module B, thereby linking the three modules. EIF3J is a labile subunit that binds to the eIF-3 complex via EIF3B. The eIF-3 complex interacts with RPS6KB1 under conditions of nutrient depletion. Mitogenic stimulation leads to binding and activation of a complex composed of MTOR and RPTOR, leading to phosphorylation and release of RPS6KB1 and binding of EIF4B to eIF-3.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is required for several steps in the initiation of protein synthesis. The eIF-3 complex associates with the 40S ribosome and facilitates the recruitment of eIF-1, eIF-1A, eIF-2:GTP:methionyl-tRNAi and eIF-5 to form the 43S pre-initiation complex (43S PIC). The eIF-3 complex stimulates mRNA recruitment to the 43S PIC and scanning of the mRNA for AUG recognition. The eIF-3 complex is also required for disassembly and recycling of post-termination ribosomal complexes and subsequently prevents premature joining of the 40S and 60S ribosomal subunits prior to initiation. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation, including cell cycling, differentiation and apoptosis, and uses different modes of RNA stem-loop binding to exert either translational activation or repression.|||Cytoplasm|||Phosphorylated by TGF-beta type II receptor. http://togogenome.org/gene/13616:EXOC4 ^@ http://purl.uniprot.org/uniprot/F7C1U2 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/13616:HNRNPC ^@ http://purl.uniprot.org/uniprot/A0A5F8GVE6 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/13616:CTNNAL1 ^@ http://purl.uniprot.org/uniprot/F6PLE8 ^@ Similarity ^@ Belongs to the vinculin/alpha-catenin family. http://togogenome.org/gene/13616:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GL29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/13616:JAKMIP2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE67|||http://purl.uniprot.org/uniprot/F6TKE6 ^@ Similarity ^@ Belongs to the JAKMIP family. http://togogenome.org/gene/13616:IL7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQJ7|||http://purl.uniprot.org/uniprot/K7E262 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-7/IL-9 family.|||Secreted http://togogenome.org/gene/13616:GSKIP ^@ http://purl.uniprot.org/uniprot/A0A5F8H934 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/13616:LOC100026408 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:DERL1 ^@ http://purl.uniprot.org/uniprot/F7GED8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/13616:NMBR ^@ http://purl.uniprot.org/uniprot/F6SMW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TXLNG ^@ http://purl.uniprot.org/uniprot/F6QDN1 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/13616:WNT7B ^@ http://purl.uniprot.org/uniprot/F7EF09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/13616:REEP3 ^@ http://purl.uniprot.org/uniprot/F6XFM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/13616:MERTK ^@ http://purl.uniprot.org/uniprot/A0A5F8HGC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/13616:XIAP ^@ http://purl.uniprot.org/uniprot/F7CGN1 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/13616:ADGRL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPB8|||http://purl.uniprot.org/uniprot/F7ANV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NT5DC2 ^@ http://purl.uniprot.org/uniprot/F6W363 ^@ Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family. http://togogenome.org/gene/13616:PDIA6 ^@ http://purl.uniprot.org/uniprot/F7DLQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/13616:UBAC1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCZ7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:SH3BGRL3 ^@ http://purl.uniprot.org/uniprot/F6U6M6 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/13616:PSMB2 ^@ http://purl.uniprot.org/uniprot/F7FGF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:GREM1 ^@ http://purl.uniprot.org/uniprot/F6V0D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/13616:DPH2 ^@ http://purl.uniprot.org/uniprot/F6Q4T5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/13616:GUK1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GX57 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/13616:FAM171B ^@ http://purl.uniprot.org/uniprot/F7CKF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/13616:RPL15 ^@ http://purl.uniprot.org/uniprot/F6YKQ8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/13616:SHROOM3 ^@ http://purl.uniprot.org/uniprot/F7GDF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/13616:ACVR2A ^@ http://purl.uniprot.org/uniprot/F7EG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/13616:KCNB1 ^@ http://purl.uniprot.org/uniprot/F7AU20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||sarcolemma|||synaptosome http://togogenome.org/gene/13616:TOX4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GQ66|||http://purl.uniprot.org/uniprot/F7EIC0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100024696 ^@ http://purl.uniprot.org/uniprot/F6PN14 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:CYLD ^@ http://purl.uniprot.org/uniprot/A0A5F8GGS3|||http://purl.uniprot.org/uniprot/F7BMW7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/13616:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/F7ADI1 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/13616:SLC30A4 ^@ http://purl.uniprot.org/uniprot/F6ZSD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100029003 ^@ http://purl.uniprot.org/uniprot/F7DFS1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:MILL-like ^@ http://purl.uniprot.org/uniprot/A0A5F8GUB8|||http://purl.uniprot.org/uniprot/D7URV5 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:ITPRIPL2 ^@ http://purl.uniprot.org/uniprot/F6RPK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/13616:PBX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG23|||http://purl.uniprot.org/uniprot/A0A5F8GLW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/13616:HOMER1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G504|||http://purl.uniprot.org/uniprot/F6XMC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/13616:TINAG ^@ http://purl.uniprot.org/uniprot/F6ZNT2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/13616:GHITM ^@ http://purl.uniprot.org/uniprot/F6S7G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/13616:LDHA ^@ http://purl.uniprot.org/uniprot/Q9XT87 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LDH/MDH superfamily. LDH family.|||Cytoplasm|||Homotetramer. Interacts with PTEN upstream reading frame protein MP31.|||ISGylated.|||Interconverts simultaneously and stereospecifically pyruvate and lactate with concomitant interconversion of NADH and NAD(+). http://togogenome.org/gene/13616:MTFR2 ^@ http://purl.uniprot.org/uniprot/F6Z5S7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/13616:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/F7BAK0 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:HSPA4L ^@ http://purl.uniprot.org/uniprot/F6YGK6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:FAM212A ^@ http://purl.uniprot.org/uniprot/F6PN08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus http://togogenome.org/gene/13616:DHRS9 ^@ http://purl.uniprot.org/uniprot/F6YT90 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/13616:FAM110A ^@ http://purl.uniprot.org/uniprot/A0A5F8G3U7 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/13616:SUSD6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCH6|||http://purl.uniprot.org/uniprot/F6T5F1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:VN2R589 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJZ0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:HLF ^@ http://purl.uniprot.org/uniprot/F7BZ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/13616:ANXA1 ^@ http://purl.uniprot.org/uniprot/F7GEB8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Basolateral cell membrane|||Belongs to the annexin family.|||Cell membrane|||Lateral cell membrane|||Membrane|||Nucleus|||The full-length protein can bind eight Ca(2+) ions via the annexin repeats. Calcium binding causes a major conformation change that modifies dimer contacts and leads to surface exposure of the N-terminal phosphorylation sites; in the absence of Ca(2+), these sites are buried in the interior of the protein core. The N-terminal region becomes disordered in response to calcium-binding.|||cilium|||extracellular exosome|||extracellular space|||phagocytic cup|||secretory vesicle lumen http://togogenome.org/gene/13616:B4GALT5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFK8|||http://purl.uniprot.org/uniprot/F7ATF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/13616:LOC100028022 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:MRPL15 ^@ http://purl.uniprot.org/uniprot/F7G026 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/13616:LOC100028071 ^@ http://purl.uniprot.org/uniprot/F7G822 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/13616:FBLN1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GND2|||http://purl.uniprot.org/uniprot/F7FCJ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:TNS4 ^@ http://purl.uniprot.org/uniprot/F6ZL55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PTEN phosphatase protein family.|||focal adhesion http://togogenome.org/gene/13616:DIS3L ^@ http://purl.uniprot.org/uniprot/F6WT23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNR ribonuclease family.|||Component of the RNA exosome complex. The catalytically inactive RNA exosome core (Exo-9) complex is believed to associate with catalytic subunits EXOSC10, and DIS3 or DIS3L in cytoplasmic- and nuclear-specific RNA exosome complex forms.|||Cytoplasm|||Putative cytoplasm-specific catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pathways, preventing translation of aberrant mRNAs. It seems to be involved in degradation of histone mRNA. http://togogenome.org/gene/13616:PRUNE ^@ http://purl.uniprot.org/uniprot/A0A5F8GL48|||http://purl.uniprot.org/uniprot/A0A5F8HCR2 ^@ Similarity ^@ Belongs to the PPase class C family. Prune subfamily. http://togogenome.org/gene/13616:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR62|||http://purl.uniprot.org/uniprot/F7EUM5 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/13616:PPIL4 ^@ http://purl.uniprot.org/uniprot/F6R2R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:PGM3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H855 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/13616:AMER1 ^@ http://purl.uniprot.org/uniprot/F6WT87 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/13616:SIX5 ^@ http://purl.uniprot.org/uniprot/A0A5F8GNT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ERCC4 ^@ http://purl.uniprot.org/uniprot/F6U5H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/13616:PSMG1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG1 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer binds to the PSMA5 and PSMA7 proteasome subunits, promotes assembly of the proteasome alpha subunits into the heteroheptameric alpha ring and prevents alpha ring dimerization.|||Forms a heterodimer with PSMG2. The PSMG1-PSMG2 heterodimer interacts directly with the PSMA5 and PSMA7 proteasome alpha subunits. http://togogenome.org/gene/13616:SELP ^@ http://purl.uniprot.org/uniprot/F6WDI7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the selectin/LECAM family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:FOXO1 ^@ http://purl.uniprot.org/uniprot/F6S918 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PSEN1 ^@ http://purl.uniprot.org/uniprot/F6PH04 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Cytoplasmic granule|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||Synapse|||The PAL motif is required for normal active site conformation.|||axon|||neuron projection http://togogenome.org/gene/13616:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/F7F4D0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/13616:T2R23 ^@ http://purl.uniprot.org/uniprot/Q2AB96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:RSL24D1 ^@ http://purl.uniprot.org/uniprot/A0A5F8H690 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/13616:LOC103106436 ^@ http://purl.uniprot.org/uniprot/F7DM38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sesquipedalian family.|||Early endosome|||Forms homodimers and heterodimers with PHETA. Interacts with OCRL and INPP5B.|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/13616:CDK6 ^@ http://purl.uniprot.org/uniprot/F7CIV1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:C4H11orf70 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0N3|||http://purl.uniprot.org/uniprot/F6X4G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/13616:LOC100010038 ^@ http://purl.uniprot.org/uniprot/F6S0C9 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/13616:SGK2 ^@ http://purl.uniprot.org/uniprot/F7CJ36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/13616:BMX ^@ http://purl.uniprot.org/uniprot/A0A5F8HHY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:CPE ^@ http://purl.uniprot.org/uniprot/F7G381 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Membrane|||Sorting receptor that directs prohormones to the regulated secretory pathway. Acts also as a prohormone processing enzyme in neuro/endocrine cells, removing dibasic residues from the C-terminal end of peptide hormone precursors after initial endoprotease cleavage.|||secretory vesicle membrane http://togogenome.org/gene/13616:APEX1 ^@ http://purl.uniprot.org/uniprot/F6SH72 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair enzymes AP/ExoA family.|||Cytoplasm|||Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends.|||Mitochondrion|||Nucleus|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/13616:FOXN2 ^@ http://purl.uniprot.org/uniprot/F7GHF9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:HOXB13 ^@ http://purl.uniprot.org/uniprot/F7EIT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:C5H11orf49 ^@ http://purl.uniprot.org/uniprot/A0A5F8GII6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSTPP1 family.|||centriolar satellite http://togogenome.org/gene/13616:ICMT ^@ http://purl.uniprot.org/uniprot/A0A5F8HIQ5|||http://purl.uniprot.org/uniprot/F7AHJ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Catalyzes the post-translational methylation of isoprenylated C-terminal cysteine residues.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:LOC103104746 ^@ http://purl.uniprot.org/uniprot/F7FR61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GRK6 ^@ http://purl.uniprot.org/uniprot/F6Y4G2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/13616:TLR6 ^@ http://purl.uniprot.org/uniprot/F7ENG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/13616:TXNRD3 ^@ http://purl.uniprot.org/uniprot/F7FNP7 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/13616:IRF1 ^@ http://purl.uniprot.org/uniprot/F6RS54 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/13616:DPH5 ^@ http://purl.uniprot.org/uniprot/F6ZPK7 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/13616:LOC100020632 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:LCAT ^@ http://purl.uniprot.org/uniprot/F7G613 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/13616:ETV6 ^@ http://purl.uniprot.org/uniprot/F6PG63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/13616:SYNGR3 ^@ http://purl.uniprot.org/uniprot/F7GIR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/13616:OAZ2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G915 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/13616:MODO-UK ^@ http://purl.uniprot.org/uniprot/A0A5F8H5G0|||http://purl.uniprot.org/uniprot/C6ZIV1 ^@ Similarity ^@ Belongs to the MHC class I family. http://togogenome.org/gene/13616:LOC100028327 ^@ http://purl.uniprot.org/uniprot/F6RQ25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100017013 ^@ http://purl.uniprot.org/uniprot/F6YZG1 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/13616:BLOC1S5 ^@ http://purl.uniprot.org/uniprot/A0A5F8G6U5 ^@ Function|||Similarity ^@ Belongs to the BLOC1S5 family.|||Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO). http://togogenome.org/gene/13616:TGFB3 ^@ http://purl.uniprot.org/uniprot/F6VL66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/13616:LOC100015171 ^@ http://purl.uniprot.org/uniprot/A0A5F8G645 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat coronin family.|||Cytoplasmic vesicle|||F-actin regulator involved in anterograde Golgi to endosome transport: upon ubiquitination via 'Lys-33'-linked ubiquitin chains by the BCR(KLHL20) E3 ubiquitin ligase complex, interacts with EPS15 and localizes to the trans-Golgi network, where it promotes actin polymerization, thereby facilitating post-Golgi trafficking. May play a role in the maintenance of the Golgi apparatus morphology.|||Golgi apparatus membrane|||Membrane|||Vesicle|||cytosol|||trans-Golgi network http://togogenome.org/gene/13616:CBS ^@ http://purl.uniprot.org/uniprot/A0A5F8G6S9|||http://purl.uniprot.org/uniprot/F6QYX0 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/13616:ITPKC ^@ http://purl.uniprot.org/uniprot/A0A5F8H6M1 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/13616:RAD1 ^@ http://purl.uniprot.org/uniprot/F7C062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/13616:CHRNB4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVY2|||http://purl.uniprot.org/uniprot/F7EHD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:SPATA6 ^@ http://purl.uniprot.org/uniprot/A0A5F8H8H6|||http://purl.uniprot.org/uniprot/A0A5F8HA61|||http://purl.uniprot.org/uniprot/F7FJK4 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/13616:LOC100010184 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6V1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:VN2R511 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLQ7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPM8 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/13616:CCBL2 ^@ http://purl.uniprot.org/uniprot/F6PMN5 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/13616:VN2R648 ^@ http://purl.uniprot.org/uniprot/F6WGY3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/F7C1J9 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/13616:MRPL10 ^@ http://purl.uniprot.org/uniprot/A0A5F8GLG1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/13616:MARVELD3 ^@ http://purl.uniprot.org/uniprot/F7CVN3|||http://purl.uniprot.org/uniprot/F7FQM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DRGX ^@ http://purl.uniprot.org/uniprot/F7GLS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:ACER1 ^@ http://purl.uniprot.org/uniprot/F6W146 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:COPS7A ^@ http://purl.uniprot.org/uniprot/F7FFA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:GPSM2 ^@ http://purl.uniprot.org/uniprot/F7CVY1 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/13616:PRKRA ^@ http://purl.uniprot.org/uniprot/F6RX51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRKRA family.|||perinuclear region http://togogenome.org/gene/13616:FZD7 ^@ http://purl.uniprot.org/uniprot/F7A659 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:MTERF3 ^@ http://purl.uniprot.org/uniprot/F6QV92 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/13616:RPS19BP1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AROS family.|||nucleolus http://togogenome.org/gene/13616:PCK1 ^@ http://purl.uniprot.org/uniprot/F7EQD6 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/13616:LOC103101763 ^@ http://purl.uniprot.org/uniprot/F6UMQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/13616:PDIA4 ^@ http://purl.uniprot.org/uniprot/F6SNH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:CRYAB ^@ http://purl.uniprot.org/uniprot/F7ATA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||May contribute to the transparency and refractive index of the lens. Has chaperone-like activity, preventing aggregation of various proteins under a wide range of stress conditions.|||Nucleus http://togogenome.org/gene/13616:MDH2 ^@ http://purl.uniprot.org/uniprot/F6QQ58|||http://purl.uniprot.org/uniprot/Q0QF50 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/13616:PSMA1 ^@ http://purl.uniprot.org/uniprot/F7FBS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/13616:SLC35C1 ^@ http://purl.uniprot.org/uniprot/F6WL14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPT transporter family. SLC35C subfamily.|||Membrane http://togogenome.org/gene/13616:C1H14orf159 ^@ http://purl.uniprot.org/uniprot/F7G523 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/13616:TMEM229B ^@ http://purl.uniprot.org/uniprot/F7FLF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM229 family.|||Membrane http://togogenome.org/gene/13616:CSE1L ^@ http://purl.uniprot.org/uniprot/F7BH91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPO2/CSE1 family.|||Cytoplasm http://togogenome.org/gene/13616:monDomV1R1231 ^@ http://purl.uniprot.org/uniprot/A0A5F8GPM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SMO ^@ http://purl.uniprot.org/uniprot/F7E7J3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/13616:TARDBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GU32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:HMGCS2 ^@ http://purl.uniprot.org/uniprot/K7E2K1 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/13616:LOC100013176 ^@ http://purl.uniprot.org/uniprot/K7E155 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/13616:TAS2R4 ^@ http://purl.uniprot.org/uniprot/Q2ABA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane|||cilium membrane http://togogenome.org/gene/13616:THBS4 ^@ http://purl.uniprot.org/uniprot/F6TBV7 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A5F8GG01|||http://purl.uniprot.org/uniprot/A0A5F8H3V9|||http://purl.uniprot.org/uniprot/F7EIR1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:IL4I1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HC18 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/13616:LOC100015376 ^@ http://purl.uniprot.org/uniprot/F7CK00 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Component of the 40S small ribosomal subunit.|||Rough endoplasmic reticulum http://togogenome.org/gene/13616:RPS6KA3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5B8|||http://purl.uniprot.org/uniprot/F6YJ34 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/13616:TGM6 ^@ http://purl.uniprot.org/uniprot/A0A5F8G572 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/13616:CARNMT1 ^@ http://purl.uniprot.org/uniprot/F6RI81 ^@ Similarity ^@ Belongs to the carnosine N-methyltransferase family. http://togogenome.org/gene/13616:LOC103097786 ^@ http://purl.uniprot.org/uniprot/A0A5F8GT22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:SS18 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2A1|||http://purl.uniprot.org/uniprot/F7FSI0 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/13616:GMPPB ^@ http://purl.uniprot.org/uniprot/F7GKQ3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/13616:GIP ^@ http://purl.uniprot.org/uniprot/K7E4A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Potent stimulator of insulin secretion and relatively poor inhibitor of gastric acid secretion.|||Secreted http://togogenome.org/gene/13616:TMBIM6 ^@ http://purl.uniprot.org/uniprot/F6TEK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/13616:HEBP2 ^@ http://purl.uniprot.org/uniprot/F6SKT0 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/13616:CLN8 ^@ http://purl.uniprot.org/uniprot/F6TRC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SOX6 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYF9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:PPP2CA ^@ http://purl.uniprot.org/uniprot/F6U7A6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/13616:LOC100027367 ^@ http://purl.uniprot.org/uniprot/A0A5F8GDE2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/13616:KIF4A ^@ http://purl.uniprot.org/uniprot/A0A5F8HH41|||http://purl.uniprot.org/uniprot/F6TNW7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:SERPINA6 ^@ http://purl.uniprot.org/uniprot/F7EH65 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/13616:CHRNA1 ^@ http://purl.uniprot.org/uniprot/F7C5D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC100021638 ^@ http://purl.uniprot.org/uniprot/F6SKZ7 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/13616:GNB2 ^@ http://purl.uniprot.org/uniprot/F6Y3N2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/13616:TRPC3 ^@ http://purl.uniprot.org/uniprot/F7GJV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CAPN7 ^@ http://purl.uniprot.org/uniprot/F7ERL1 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/13616:STEAP2 ^@ http://purl.uniprot.org/uniprot/F7A6U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/13616:FAM46A ^@ http://purl.uniprot.org/uniprot/F6VNK9 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/13616:LOC100616863 ^@ http://purl.uniprot.org/uniprot/F7G8I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100020151 ^@ http://purl.uniprot.org/uniprot/F6YFN1 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/13616:TTC38 ^@ http://purl.uniprot.org/uniprot/F6YZQ3 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/13616:CLDN16 ^@ http://purl.uniprot.org/uniprot/F7F3I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/13616:GFM1 ^@ http://purl.uniprot.org/uniprot/F7EHU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/13616:monDomV1R1252 ^@ http://purl.uniprot.org/uniprot/A0A5F8GJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100024582 ^@ http://purl.uniprot.org/uniprot/F7F0P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:APAF1 ^@ http://purl.uniprot.org/uniprot/F7FNF3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/13616:LOC100020163 ^@ http://purl.uniprot.org/uniprot/F7APY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/13616:TXNDC5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/13616:TSG101 ^@ http://purl.uniprot.org/uniprot/F7FD96 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/13616:LOC100029118 ^@ http://purl.uniprot.org/uniprot/F7G3B7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/13616:NUBP2 ^@ http://purl.uniprot.org/uniprot/F7EAL9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NUBP1 and two labile, bridging clusters between subunits of the NUBP1-NUBP2 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NUBP1-NUBP2 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NUBP1 and 2 NUBP2 chains. Interacts with KIFC1.|||Nucleus|||centrosome http://togogenome.org/gene/13616:TGFBR1 ^@ http://purl.uniprot.org/uniprot/F6VGC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100015397 ^@ http://purl.uniprot.org/uniprot/F6R601 ^@ Similarity|||Subunit ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family.|||Interacts with PDZK1. http://togogenome.org/gene/13616:LOC100028075 ^@ http://purl.uniprot.org/uniprot/A0A5F8H1K9 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/13616:KIAA0101 ^@ http://purl.uniprot.org/uniprot/A0A5F8H0S8 ^@ Subcellular Location Annotation ^@ Nucleus|||perinuclear region http://togogenome.org/gene/13616:PRDM13 ^@ http://purl.uniprot.org/uniprot/F7FT76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SEC23A ^@ http://purl.uniprot.org/uniprot/F7B980 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/13616:LOC100026087 ^@ http://purl.uniprot.org/uniprot/F6TDE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-1 family.|||Secreted http://togogenome.org/gene/13616:UNC50 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYM5|||http://purl.uniprot.org/uniprot/A0A5F8HET6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/13616:PDGFC ^@ http://purl.uniprot.org/uniprot/F6XG94 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100021613 ^@ http://purl.uniprot.org/uniprot/F6SLC4 ^@ Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/13616:DCLRE1C ^@ http://purl.uniprot.org/uniprot/A0A5F8G287|||http://purl.uniprot.org/uniprot/A0A5F8G808|||http://purl.uniprot.org/uniprot/F6VMY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA repair metallo-beta-lactamase (DRMBL) family.|||Nucleus http://togogenome.org/gene/13616:NUPR1 ^@ http://purl.uniprot.org/uniprot/F7FEK1 ^@ Similarity ^@ Belongs to the NUPR family. http://togogenome.org/gene/13616:CTGF ^@ http://purl.uniprot.org/uniprot/F7BSS5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100022878 ^@ http://purl.uniprot.org/uniprot/F7D6V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FAIM2 ^@ http://purl.uniprot.org/uniprot/F6SX86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/13616:LOC100027302 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDR3 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/13616:KCNK6 ^@ http://purl.uniprot.org/uniprot/F7B062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/13616:VN2R647 ^@ http://purl.uniprot.org/uniprot/A0A5F8GY18 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/13616:GABRG1 ^@ http://purl.uniprot.org/uniprot/F7A086 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC100015233 ^@ http://purl.uniprot.org/uniprot/A0A5F8GCD6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/13616:CTF1 ^@ http://purl.uniprot.org/uniprot/F6S7D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/13616:IGF2R ^@ http://purl.uniprot.org/uniprot/A0A5F8GGA5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:AQP4 ^@ http://purl.uniprot.org/uniprot/A0A5F8H602 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/13616:LOC100617410 ^@ http://purl.uniprot.org/uniprot/F7C814 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PCYOX1 ^@ http://purl.uniprot.org/uniprot/F6RI07 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/13616:PLPP5 ^@ http://purl.uniprot.org/uniprot/F7GH71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:USP39 ^@ http://purl.uniprot.org/uniprot/F7FEM4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MZT2B ^@ http://purl.uniprot.org/uniprot/F6V599 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MOZART2 family.|||centrosome|||spindle http://togogenome.org/gene/13616:LOC100017553 ^@ http://purl.uniprot.org/uniprot/F6RBQ7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/13616:PDE6G ^@ http://purl.uniprot.org/uniprot/F7CXV2 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/13616:NDST4 ^@ http://purl.uniprot.org/uniprot/F7A1T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/13616:LOC100026263 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5A1|||http://purl.uniprot.org/uniprot/F6V733 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/13616:LOC100022399 ^@ http://purl.uniprot.org/uniprot/F6XFI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:CCR4 ^@ http://purl.uniprot.org/uniprot/F7BE29 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:LSM12 ^@ http://purl.uniprot.org/uniprot/F7CBC3 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/13616:STK11IP ^@ http://purl.uniprot.org/uniprot/F7FHM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STK11IP family.|||Cytoplasm http://togogenome.org/gene/13616:C7H2orf40 ^@ http://purl.uniprot.org/uniprot/F7G527 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/13616:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXR5|||http://purl.uniprot.org/uniprot/F6QHS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:CD36 ^@ http://purl.uniprot.org/uniprot/F6VKJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/13616:ZFHX2 ^@ http://purl.uniprot.org/uniprot/F6UB49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:CRB2 ^@ http://purl.uniprot.org/uniprot/F6X3Y3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:RAB32 ^@ http://purl.uniprot.org/uniprot/A0A5F8GW92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/13616:SLC16A1 ^@ http://purl.uniprot.org/uniprot/F7F824 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. http://togogenome.org/gene/13616:RBM5 ^@ http://purl.uniprot.org/uniprot/F7EJ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/13616:BARX1 ^@ http://purl.uniprot.org/uniprot/F6PVA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SUSD1 ^@ http://purl.uniprot.org/uniprot/F7FV45 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:CITED4 ^@ http://purl.uniprot.org/uniprot/F6VBX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/13616:SCNN1B ^@ http://purl.uniprot.org/uniprot/F6PGF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:RPL7 ^@ http://purl.uniprot.org/uniprot/F6RZC7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/13616:MYF5 ^@ http://purl.uniprot.org/uniprot/F7FIX4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Induces fibroblasts to differentiate into myoblasts. Acts as a transcriptional activator that promotes transcription of muscle-specific target genes and plays a role in muscle differentiation.|||Nucleus http://togogenome.org/gene/13616:NR2E3 ^@ http://purl.uniprot.org/uniprot/F6VJQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/13616:ZP3 ^@ http://purl.uniprot.org/uniprot/K7DZ89 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Membrane|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/13616:SNRPA1 ^@ http://purl.uniprot.org/uniprot/F7AM15 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/13616:MTAP ^@ http://purl.uniprot.org/uniprot/A0A5F8GH24 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/13616:ADAMTS4 ^@ http://purl.uniprot.org/uniprot/F7DMX5 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:CACYBP ^@ http://purl.uniprot.org/uniprot/A0A5F8GM41 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/13616:RNF157 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMR4|||http://purl.uniprot.org/uniprot/F7F2M0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/13616:LOC100618096 ^@ http://purl.uniprot.org/uniprot/F7D2A4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:ALX3 ^@ http://purl.uniprot.org/uniprot/F6WZK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:EIF4E2 ^@ http://purl.uniprot.org/uniprot/F7AZJ1 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/13616:LOC100018815 ^@ http://purl.uniprot.org/uniprot/A0A5F8H720 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LTK ^@ http://purl.uniprot.org/uniprot/A0A5F8G4G8|||http://purl.uniprot.org/uniprot/F6YBY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily. http://togogenome.org/gene/13616:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A5F8GSL1|||http://purl.uniprot.org/uniprot/D2X2I9|||http://purl.uniprot.org/uniprot/F7EIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:FAT3 ^@ http://purl.uniprot.org/uniprot/A0A5F8HHQ8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:PLAT ^@ http://purl.uniprot.org/uniprot/A0A5F8G353|||http://purl.uniprot.org/uniprot/F6WLY7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100028279 ^@ http://purl.uniprot.org/uniprot/A0A5F8GE81 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/13616:LOC100031889 ^@ http://purl.uniprot.org/uniprot/F7D1P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:RPL10 ^@ http://purl.uniprot.org/uniprot/F6PU97 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/13616:ELAC2 ^@ http://purl.uniprot.org/uniprot/F6YKA6 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/13616:ING5 ^@ http://purl.uniprot.org/uniprot/F6PGK8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/13616:ACOX3 ^@ http://purl.uniprot.org/uniprot/F6WE42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/13616:JAK2 ^@ http://purl.uniprot.org/uniprot/F6WH53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/13616:LOC100033022 ^@ http://purl.uniprot.org/uniprot/A0A5F8GU60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:PXMP4 ^@ http://purl.uniprot.org/uniprot/F7E2H8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Interacts with PEX19.|||Peroxisome membrane http://togogenome.org/gene/13616:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFE7|||http://purl.uniprot.org/uniprot/F6PRT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/13616:LOC100023209 ^@ http://purl.uniprot.org/uniprot/F7EAU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100012625 ^@ http://purl.uniprot.org/uniprot/F7GGR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TIMM44 ^@ http://purl.uniprot.org/uniprot/F7ASY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:FABP5 ^@ http://purl.uniprot.org/uniprot/F7BV76 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/13616:LOC100025932 ^@ http://purl.uniprot.org/uniprot/A0A5F8G8X6 ^@ Similarity ^@ Belongs to the MHC class II family. http://togogenome.org/gene/13616:LOC100021136 ^@ http://purl.uniprot.org/uniprot/F6STC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:T2R3H ^@ http://purl.uniprot.org/uniprot/Q2ABA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/13616:CACNA1S ^@ http://purl.uniprot.org/uniprot/F7AXC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane|||Voltage-sensitive calcium channels (VSCC) mediate the entry of calcium ions into excitable cells and are also involved in a variety of calcium-dependent processes, including muscle contraction, hormone or neurotransmitter release, gene expression, cell motility, cell division and cell death. http://togogenome.org/gene/13616:HCK ^@ http://purl.uniprot.org/uniprot/F6RBD8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/13616:NDUFA6 ^@ http://purl.uniprot.org/uniprot/F6UFT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed to be not involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I LYR family.|||Mammalian complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:OPRD1 ^@ http://purl.uniprot.org/uniprot/F6ZBS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PLPPR2 ^@ http://purl.uniprot.org/uniprot/F7EK18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/13616:SCD5 ^@ http://purl.uniprot.org/uniprot/F7B9J1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/13616:RPRD1B ^@ http://purl.uniprot.org/uniprot/A0A5F8H8W1|||http://purl.uniprot.org/uniprot/F6SZY6 ^@ Function|||Similarity|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the UPF0400 (RTT103) family.|||Interacts with phosphorylated C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and participates in dephosphorylation of the CTD. http://togogenome.org/gene/13616:KIN ^@ http://purl.uniprot.org/uniprot/F7CHY4 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/13616:ADGRF4 ^@ http://purl.uniprot.org/uniprot/F7DVI2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:PRKAA2 ^@ http://purl.uniprot.org/uniprot/F7FPU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:IRGC ^@ http://purl.uniprot.org/uniprot/F6RL76 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family. http://togogenome.org/gene/13616:LOC100027512 ^@ http://purl.uniprot.org/uniprot/F6WFL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:POMK ^@ http://purl.uniprot.org/uniprot/A0A5F8GTZ9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/13616:LOC100021101 ^@ http://purl.uniprot.org/uniprot/F6RNV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EPB42 ^@ http://purl.uniprot.org/uniprot/F6Z8B1 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/13616:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H208 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/13616:LOC100012481 ^@ http://purl.uniprot.org/uniprot/F6Z4W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100013978 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:C4H11orf54 ^@ http://purl.uniprot.org/uniprot/F6QLW1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/13616:MTMR11 ^@ http://purl.uniprot.org/uniprot/F7DXN5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/13616:BARHL1 ^@ http://purl.uniprot.org/uniprot/F6PNM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:monDomV1R1257 ^@ http://purl.uniprot.org/uniprot/A0A5F8GAR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:VGLL1 ^@ http://purl.uniprot.org/uniprot/F6R4K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/13616:ZC3H12B ^@ http://purl.uniprot.org/uniprot/F7A243 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/13616:ADGRL2 ^@ http://purl.uniprot.org/uniprot/A0A5F8GFP9|||http://purl.uniprot.org/uniprot/A0A5F8GKV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SH3BGRL ^@ http://purl.uniprot.org/uniprot/F6X6Y2 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/13616:GBX2 ^@ http://purl.uniprot.org/uniprot/F7GJL0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:DAP3 ^@ http://purl.uniprot.org/uniprot/F6Y0W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/13616:KLHL22 ^@ http://purl.uniprot.org/uniprot/A0A5F8GXU5 ^@ Subcellular Location Annotation ^@ Lysosome|||Nucleus|||centrosome|||cytosol|||spindle http://togogenome.org/gene/13616:TJP3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GRP3|||http://purl.uniprot.org/uniprot/F6WP06 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/13616:TCN2 ^@ http://purl.uniprot.org/uniprot/F6QKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic cobalamin transport proteins family.|||Secreted http://togogenome.org/gene/13616:SV2B ^@ http://purl.uniprot.org/uniprot/F6YVN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/13616:TSR3 ^@ http://purl.uniprot.org/uniprot/F7FYA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1248 (Psi1248) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:ALG10 ^@ http://purl.uniprot.org/uniprot/F6RK69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/13616:TSSC1 ^@ http://purl.uniprot.org/uniprot/F7ATW7 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/13616:GFRA3 ^@ http://purl.uniprot.org/uniprot/F7CXX6 ^@ Similarity ^@ Belongs to the GDNFR family. http://togogenome.org/gene/13616:UBE2D2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HBV9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/13616:ENO3 ^@ http://purl.uniprot.org/uniprot/F7E6Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/13616:MED13L ^@ http://purl.uniprot.org/uniprot/F6WRU4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex, which is composed of MED1, MED4, MED6, MED7, MED8, MED9, MED10, MED11, MED12, MED13, MED13L, MED14, MED15, MED16, MED17, MED18, MED19, MED20, MED21, MED22, MED23, MED24, MED25, MED26, MED27, MED29, MED30, MED31, CCNC, CDK8 and CDC2L6/CDK11. The MED12, MED13, CCNC and CDK8 subunits form a distinct module termed the CDK8 module. Mediator containing the CDK8 module is less active than Mediator lacking this module in supporting transcriptional activation. Individual preparations of the Mediator complex lacking one or more distinct subunits have been variously termed ARC, CRSP, DRIP, PC2, SMCC and TRAP.|||Nucleus http://togogenome.org/gene/13616:PPIF ^@ http://purl.uniprot.org/uniprot/F7D520 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/13616:PPIP5K1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G669|||http://purl.uniprot.org/uniprot/A0A5F8GQ04|||http://purl.uniprot.org/uniprot/A0A5F8GY01|||http://purl.uniprot.org/uniprot/A0A5F8H6Y7|||http://purl.uniprot.org/uniprot/A0A5F8H8F8|||http://purl.uniprot.org/uniprot/F6U4W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/13616:NPFFR2 ^@ http://purl.uniprot.org/uniprot/F7F980 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/13616:RHBDL3 ^@ http://purl.uniprot.org/uniprot/A0A5F8G236|||http://purl.uniprot.org/uniprot/F7AX77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||May be involved in regulated intramembrane proteolysis and the subsequent release of functional polypeptides from their membrane anchors.|||Membrane http://togogenome.org/gene/13616:RAB21 ^@ http://purl.uniprot.org/uniprot/F7BE89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cleavage furrow|||Cytoplasmic vesicle membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||neuron projection|||trans-Golgi network http://togogenome.org/gene/13616:CDR2 ^@ http://purl.uniprot.org/uniprot/F7BJ14 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/13616:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A5F8H2D2|||http://purl.uniprot.org/uniprot/A0A5F8HAW9 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/13616:STAT1 ^@ http://purl.uniprot.org/uniprot/F7DFB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:HOXD11 ^@ http://purl.uniprot.org/uniprot/F7BJ45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/13616:ADAMTS8 ^@ http://purl.uniprot.org/uniprot/F6ZDR1 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/13616:LHB ^@ http://purl.uniprot.org/uniprot/Q95J85 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit beta family.|||Heterodimer of a common alpha chain and a unique beta chain which confers biological specificity to thyrotropin, lutropin, follitropin and gonadotropin.|||Promotes spermatogenesis and ovulation by stimulating the testes and ovaries to synthesize steroids.|||Secreted http://togogenome.org/gene/13616:CPSF7 ^@ http://purl.uniprot.org/uniprot/A0A5F8GG91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CPSF6/7 family.|||Nucleus http://togogenome.org/gene/13616:LOC100019583 ^@ http://purl.uniprot.org/uniprot/F7FVE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRAME family. LRRC14 subfamily.|||Cytoplasm http://togogenome.org/gene/13616:LOC100010284 ^@ http://purl.uniprot.org/uniprot/F7CBA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:LOC100617599 ^@ http://purl.uniprot.org/uniprot/F7BWD5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/13616:LIG4 ^@ http://purl.uniprot.org/uniprot/F6SA46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/13616:LOC100019607 ^@ http://purl.uniprot.org/uniprot/A0A5F8GSE4 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/13616:OAF ^@ http://purl.uniprot.org/uniprot/A0A5F8HEZ6 ^@ Similarity ^@ Belongs to the OAF family. http://togogenome.org/gene/13616:IPMK ^@ http://purl.uniprot.org/uniprot/F7DS89 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/13616:EPS8 ^@ http://purl.uniprot.org/uniprot/F7EKC6 ^@ Similarity ^@ Belongs to the EPS8 family. http://togogenome.org/gene/13616:FAM73B ^@ http://purl.uniprot.org/uniprot/A0A5F8GU90 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/13616:PDE10A ^@ http://purl.uniprot.org/uniprot/A0A5F8G459|||http://purl.uniprot.org/uniprot/A0A5F8G6J9|||http://purl.uniprot.org/uniprot/A0A5F8H586 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/13616:PKD2L2 ^@ http://purl.uniprot.org/uniprot/F6YGJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Membrane http://togogenome.org/gene/13616:SLC7A14 ^@ http://purl.uniprot.org/uniprot/F7GIW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:LOC100019409 ^@ http://purl.uniprot.org/uniprot/F6UPJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HCT3|||http://purl.uniprot.org/uniprot/F7EBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/13616:LOC103104519 ^@ http://purl.uniprot.org/uniprot/K7E0W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/13616:BAZ1B ^@ http://purl.uniprot.org/uniprot/F6UBA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:KCNJ6 ^@ http://purl.uniprot.org/uniprot/F6S570 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ6 subfamily.|||Membrane http://togogenome.org/gene/13616:LOC103103797 ^@ http://purl.uniprot.org/uniprot/F7A295 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/13616:ZNF711 ^@ http://purl.uniprot.org/uniprot/A0A5F8HDU1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:LOC100023139 ^@ http://purl.uniprot.org/uniprot/F7EEG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:EPC1 ^@ http://purl.uniprot.org/uniprot/F7C5R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/13616:KIF26B ^@ http://purl.uniprot.org/uniprot/F7FCR6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/13616:STMN2 ^@ http://purl.uniprot.org/uniprot/A0A5F8H5P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stathmin family.|||Cytoplasm|||Membrane|||lamellipodium http://togogenome.org/gene/13616:LTB4R ^@ http://purl.uniprot.org/uniprot/F6Q0D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:PPM1D ^@ http://purl.uniprot.org/uniprot/F6X2X9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/13616:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A5F8G5N0 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/13616:MTR ^@ http://purl.uniprot.org/uniprot/F7DB09 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methylcob(III)alamin (MeCbl) to homocysteine, yielding enzyme-bound cob(I)alamin and methionine in the cytosol. MeCbl is an active form of cobalamin (vitamin B12) used as a cofactor for methionine biosynthesis. Cob(I)alamin form is regenerated to MeCbl by a transfer of a methyl group from 5-methyltetrahydrofolate. The processing of cobalamin in the cytosol occurs in a multiprotein complex composed of at least MMACHC, MMADHC, MTRR (methionine synthase reductase) and MTR which may contribute to shuttle safely and efficiently cobalamin towards MTR in order to produce methionine.|||Cytoplasm|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/13616:HSPA4 ^@ http://purl.uniprot.org/uniprot/F6SEX9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/13616:VPS28 ^@ http://purl.uniprot.org/uniprot/A0A5F8HK29|||http://purl.uniprot.org/uniprot/F7CIV5 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/13616:LOC100033109 ^@ http://purl.uniprot.org/uniprot/K7E2Z8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/13616:LOC100024321 ^@ http://purl.uniprot.org/uniprot/F6Q2J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:POLR3K ^@ http://purl.uniprot.org/uniprot/A0A5F8H3N3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/13616:DDX17 ^@ http://purl.uniprot.org/uniprot/F6YBU8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/13616:AVPI1 ^@ http://purl.uniprot.org/uniprot/F7CNT6 ^@ Function ^@ May be involved in MAP kinase activation, epithelial sodium channel (ENaC) down-regulation and cell cycling. http://togogenome.org/gene/13616:C1H19orf12 ^@ http://purl.uniprot.org/uniprot/F6UYN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the C19orf12 family.|||Mitochondrion membrane http://togogenome.org/gene/13616:MRE11A ^@ http://purl.uniprot.org/uniprot/F6SYM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/13616:KEG11_p13 ^@ http://purl.uniprot.org/uniprot/O78703|||http://purl.uniprot.org/uniprot/Q65CJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity).|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/13616:KDELC1 ^@ http://purl.uniprot.org/uniprot/F6SKB2 ^@ Similarity ^@ Belongs to the KDELC family. http://togogenome.org/gene/13616:FAM20B ^@ http://purl.uniprot.org/uniprot/F7FSJ9 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/13616:PPP1R10 ^@ http://purl.uniprot.org/uniprot/F6Z340 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Scaffold protein which mediates the formation of the PTW/PP1 phosphatase complex by providing a binding platform to each component of the complex. The PTW/PP1 phosphatase complex plays a role in the control of chromatin structure and cell cycle progression during the transition from mitosis into interphase. Mediates interaction of WDR82 and PPP1CA. Inhibitor of PPP1CA and PPP1CC phosphatase activities. Has inhibitory activity on PPP1CA only when phosphorylated. Binds to mRNA, single-stranded DNA (ssDNA), poly(A) and poly(G) homopolymers. http://togogenome.org/gene/13616:NR5A1 ^@ http://purl.uniprot.org/uniprot/F6WNR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/13616:MUS81 ^@ http://purl.uniprot.org/uniprot/F7FIB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/13616:CLCN4 ^@ http://purl.uniprot.org/uniprot/F6ZVD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/13616:MTCH1 ^@ http://purl.uniprot.org/uniprot/F7FM65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/13616:DNM2 ^@ http://purl.uniprot.org/uniprot/A0A5F8G2M4|||http://purl.uniprot.org/uniprot/A0A5F8G4N6|||http://purl.uniprot.org/uniprot/A0A5F8GTC4|||http://purl.uniprot.org/uniprot/A0A5F8HES7|||http://purl.uniprot.org/uniprot/F7FF74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family.|||cytoskeleton http://togogenome.org/gene/13616:SIX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GWR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SIX/Sine oculis homeobox family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:RPLP0 ^@ http://purl.uniprot.org/uniprot/F7B9X0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/13616:ITPR2 ^@ http://purl.uniprot.org/uniprot/F6ZCW7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/13616:SPPL2B ^@ http://purl.uniprot.org/uniprot/F6X1D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/13616:B3GAT2 ^@ http://purl.uniprot.org/uniprot/F7G261 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/13616:LOC100022496 ^@ http://purl.uniprot.org/uniprot/F7CU30 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/13616:NDUFC1 ^@ http://purl.uniprot.org/uniprot/F6YCC9 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFC1 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/13616:MRGPRF ^@ http://purl.uniprot.org/uniprot/F7C3B1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/13616:CD8B ^@ http://purl.uniprot.org/uniprot/I6LJ12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:NAPA ^@ http://purl.uniprot.org/uniprot/F6QA54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/13616:ABCG2 ^@ http://purl.uniprot.org/uniprot/F7ANW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Cell membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/13616:TTLL1 ^@ http://purl.uniprot.org/uniprot/K7E1S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin polyglutamylase family.|||cilium basal body http://togogenome.org/gene/13616:GLA ^@ http://purl.uniprot.org/uniprot/F6UZR4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/13616:SLC10A1 ^@ http://purl.uniprot.org/uniprot/F6SPY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane http://togogenome.org/gene/13616:PROX2 ^@ http://purl.uniprot.org/uniprot/F7BT12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:SFRP1 ^@ http://purl.uniprot.org/uniprot/F7ESJ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/13616:LOC100010993 ^@ http://purl.uniprot.org/uniprot/F6SVE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/13616:APOO ^@ http://purl.uniprot.org/uniprot/F6UIK7|||http://purl.uniprot.org/uniprot/K7E004 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/13616:DYNLRB2 ^@ http://purl.uniprot.org/uniprot/F7ELI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||Homodimer. The cytoplasmic dynein 1 complex consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits presented by intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs); the composition seems to vary in respect to the IC, LIC and LC composition. The heavy chain homodimer serves as a scaffold for the probable homodimeric assembly of the respective non-catalytic subunits. The ICs and LICs bind directly to the HC dimer and the LCs assemble on the IC dimer.|||cytoskeleton http://togogenome.org/gene/13616:POMT2 ^@ http://purl.uniprot.org/uniprot/F7CGH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/13616:PELI3 ^@ http://purl.uniprot.org/uniprot/F6Z8P2 ^@ Function|||Similarity ^@ Belongs to the pellino family.|||E3 ubiquitin ligase catalyzing the covalent attachment of ubiquitin moieties onto substrate proteins. http://togogenome.org/gene/13616:SLC1A1 ^@ http://purl.uniprot.org/uniprot/F6T507 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/13616:LOC100011711 ^@ http://purl.uniprot.org/uniprot/F6VP67 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/13616:KCTD20 ^@ http://purl.uniprot.org/uniprot/F7C3E1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/13616:LCTL ^@ http://purl.uniprot.org/uniprot/F6RDR6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/13616:SEC63 ^@ http://purl.uniprot.org/uniprot/F7AKK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:DMC1 ^@ http://purl.uniprot.org/uniprot/F6QSA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/13616:SF3B1 ^@ http://purl.uniprot.org/uniprot/F6YFZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/13616:PSMB9 ^@ http://purl.uniprot.org/uniprot/A0A5F8GR45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/13616:TMEM200C ^@ http://purl.uniprot.org/uniprot/F7EYB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/13616:ST8SIA6 ^@ http://purl.uniprot.org/uniprot/F6XAK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/13616:CCKAR ^@ http://purl.uniprot.org/uniprot/F6YC15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/13616:DOLK ^@ http://purl.uniprot.org/uniprot/F6U8P7 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/13616:ARHGEF9 ^@ http://purl.uniprot.org/uniprot/F6R1E1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Acts as guanine nucleotide exchange factor (GEF) for CDC42. Promotes formation of GPHN clusters.|||Cytoplasm|||Interacts with GPHN.|||Postsynaptic density http://togogenome.org/gene/13616:NPTX1 ^@ http://purl.uniprot.org/uniprot/A0A5F8HJF5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:LOC100616809 ^@ http://purl.uniprot.org/uniprot/A0A5F8GVQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/13616:TBC1D24 ^@ http://purl.uniprot.org/uniprot/A0A5F8GEM1|||http://purl.uniprot.org/uniprot/F6S4P5 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Interacts with ARF6.|||Membrane|||Presynapse|||Synapse http://togogenome.org/gene/13616:CTSA ^@ http://purl.uniprot.org/uniprot/F6YAH2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/13616:LGALSL ^@ http://purl.uniprot.org/uniprot/F6TYS8 ^@ Function ^@ Does not bind lactose, and may not bind carbohydrates. http://togogenome.org/gene/13616:CDC5L ^@ http://purl.uniprot.org/uniprot/F7GJW1 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/13616:ARL2 ^@ http://purl.uniprot.org/uniprot/F6SBP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/13616:RFNG ^@ http://purl.uniprot.org/uniprot/F7EG85 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SSR1 ^@ http://purl.uniprot.org/uniprot/K7E2E8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma. Interacts with palmitoylated calnexin (CALX), the interaction is required for efficient folding of glycosylated proteins.|||Membrane|||Shows a remarkable charge distribution with the N-terminus being highly negatively charged, and the cytoplasmic C-terminus positively charged.|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. May be involved in the recycling of the translocation apparatus after completion of the translocation process or may function as a membrane-bound chaperone facilitating folding of translocated proteins. http://togogenome.org/gene/13616:DPYS ^@ http://purl.uniprot.org/uniprot/F7D0P7 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/13616:GNG10 ^@ http://purl.uniprot.org/uniprot/F7CFG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/13616:SLC43A3 ^@ http://purl.uniprot.org/uniprot/F7ESB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/13616:SLC44A2 ^@ http://purl.uniprot.org/uniprot/A0A5F8HFR3|||http://purl.uniprot.org/uniprot/A0A5F8HGM4|||http://purl.uniprot.org/uniprot/F6V0S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/13616:NTRK3 ^@ http://purl.uniprot.org/uniprot/A0A5F8GYP0|||http://purl.uniprot.org/uniprot/F7FCZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/13616:DIABLO ^@ http://purl.uniprot.org/uniprot/F7CEH7 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/13616:INSL5 ^@ http://purl.uniprot.org/uniprot/A0A5F8H6Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/13616:COQ10B ^@ http://purl.uniprot.org/uniprot/F6YFX3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/13616:LEPROT ^@ http://purl.uniprot.org/uniprot/A0A5F8GNU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/13616:MKI67 ^@ http://purl.uniprot.org/uniprot/F6RFD6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/13616:MMS22L ^@ http://purl.uniprot.org/uniprot/A0A5F8GXK2|||http://purl.uniprot.org/uniprot/F7F1R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MMS22 family. MMS22L subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/13616:LOC100017398 ^@ http://purl.uniprot.org/uniprot/F7EKZ2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/13616:LSM5 ^@ http://purl.uniprot.org/uniprot/K7E2K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/13616:TTC39B ^@ http://purl.uniprot.org/uniprot/A0A5F8GCQ6|||http://purl.uniprot.org/uniprot/A0A5F8H663|||http://purl.uniprot.org/uniprot/F7CGT6 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/13616:TRUB1 ^@ http://purl.uniprot.org/uniprot/F6SH34 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/13616:MON1B ^@ http://purl.uniprot.org/uniprot/F6YR92 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/13616:DNAJC2 ^@ http://purl.uniprot.org/uniprot/F6WHU3 ^@ Function|||Subcellular Location Annotation ^@ Acts both as a chaperone in the cytosol and as a chromatin regulator in the nucleus. When cytosolic, acts as a molecular chaperone: component of the ribosome-associated complex (RAC), a complex involved in folding or maintaining nascent polypeptides in a folding-competent state. In the RAC complex, stimulates the ATPase activity of the ribosome-associated pool of Hsp70-type chaperones HSPA14 that bind to the nascent polypeptide chain. When nuclear, mediates the switching from polycomb-repressed genes to an active state: specifically recruited at histone H2A ubiquitinated at 'Lys-119' (H2AK119ub), and promotes the displacement of the polycomb PRC1 complex from chromatin, thereby facilitating transcription activation.|||cytosol http://togogenome.org/gene/13616:TIMM10 ^@ http://purl.uniprot.org/uniprot/F7ESA0 ^@ Function ^@ Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. http://togogenome.org/gene/13616:NSUN6 ^@ http://purl.uniprot.org/uniprot/F7FNT7 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/13616:SCN5A ^@ http://purl.uniprot.org/uniprot/F9W2X2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/13616:PGK1 ^@ http://purl.uniprot.org/uniprot/F7C393 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/13616:LMBR1 ^@ http://purl.uniprot.org/uniprot/F7A4I2 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/13616:GJA3 ^@ http://purl.uniprot.org/uniprot/F7G5V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/13616:ORAI1 ^@ http://purl.uniprot.org/uniprot/A0A5F8GMY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/13616:FAM212B ^@ http://purl.uniprot.org/uniprot/A0A5F8G6J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INKA family.|||Nucleus