http://togogenome.org/gene/1389489:O159_RS08840 ^@ http://purl.uniprot.org/uniprot/U3PEG0 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1389489:O159_RS02910 ^@ http://purl.uniprot.org/uniprot/U3P4Y1 ^@ Caution|||Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).|||In the C-terminal section; belongs to the IspF family.|||In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS02500 ^@ http://purl.uniprot.org/uniprot/U3PB73 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1389489:O159_RS07910 ^@ http://purl.uniprot.org/uniprot/U3PDY5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1389489:O159_RS05315 ^@ http://purl.uniprot.org/uniprot/U3P635 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/1389489:O159_RS05510 ^@ http://purl.uniprot.org/uniprot/U3P671 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS11540 ^@ http://purl.uniprot.org/uniprot/U3PFQ8 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/1389489:O159_RS09155 ^@ http://purl.uniprot.org/uniprot/U3P6U0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS01935 ^@ http://purl.uniprot.org/uniprot/U3P2T5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1389489:O159_RS09760 ^@ http://purl.uniprot.org/uniprot/U3PET9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1389489:O159_RS07165 ^@ http://purl.uniprot.org/uniprot/U3PDJ8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/1389489:O159_RS06500 ^@ http://purl.uniprot.org/uniprot/U3PD98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS09115 ^@ http://purl.uniprot.org/uniprot/U3PBA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1389489:O159_RS05670 ^@ http://purl.uniprot.org/uniprot/U3P8S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/1389489:O159_RS02585 ^@ http://purl.uniprot.org/uniprot/U3P5N4 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).|||Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS10600 ^@ http://purl.uniprot.org/uniprot/U3P9W9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1389489:O159_RS05775 ^@ http://purl.uniprot.org/uniprot/U3PCX7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1389489:O159_RS12760 ^@ http://purl.uniprot.org/uniprot/U3PD62 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1389489:O159_RS01905 ^@ http://purl.uniprot.org/uniprot/U3P593 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS04740 ^@ http://purl.uniprot.org/uniprot/U3P4B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily.|||Catalyzes the formation of the alpha-1,6-glucosidic linkages in glycogen by scission of a 1,4-alpha-linked oligosaccharide from growing alpha-1,4-glucan chains and the subsequent attachment of the oligosaccharide to the alpha-1,6 position.|||Monomer. http://togogenome.org/gene/1389489:O159_RS02130 ^@ http://purl.uniprot.org/uniprot/U3P5D4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/1389489:O159_RS01735 ^@ http://purl.uniprot.org/uniprot/U3P567 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1389489:O159_RS05285 ^@ http://purl.uniprot.org/uniprot/U3P4L3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1389489:O159_RS04780 ^@ http://purl.uniprot.org/uniprot/U3P8A9 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/1389489:O159_RS07880 ^@ http://purl.uniprot.org/uniprot/U3PAB8 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1389489:O159_RS07130 ^@ http://purl.uniprot.org/uniprot/U3PDJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS05370 ^@ http://purl.uniprot.org/uniprot/U3P8M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1389489:O159_RS07245 ^@ http://purl.uniprot.org/uniprot/U3P5Q5 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1389489:O159_RS10475 ^@ http://purl.uniprot.org/uniprot/U3P9T6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08530 ^@ http://purl.uniprot.org/uniprot/U3P6F7 ^@ Similarity ^@ Belongs to the EfeM/EfeO family. http://togogenome.org/gene/1389489:O159_RS05355 ^@ http://purl.uniprot.org/uniprot/U3P743 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/1389489:O159_RS12700 ^@ http://purl.uniprot.org/uniprot/U3PD55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1389489:O159_RS06020 ^@ http://purl.uniprot.org/uniprot/U3P928 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/1389489:O159_RS10500 ^@ http://purl.uniprot.org/uniprot/U3P9U1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1389489:O159_RS10660 ^@ http://purl.uniprot.org/uniprot/U3P7P3 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1389489:O159_RS08440 ^@ http://purl.uniprot.org/uniprot/U3P7U9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/1389489:O159_RS04980 ^@ http://purl.uniprot.org/uniprot/U3P4G0 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/1389489:O159_RS08625 ^@ http://purl.uniprot.org/uniprot/U3P8V8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 3 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS03420 ^@ http://purl.uniprot.org/uniprot/U3P5A3 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/1389489:O159_RS08025 ^@ http://purl.uniprot.org/uniprot/U3P649 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/1389489:O159_RS03300 ^@ http://purl.uniprot.org/uniprot/U3P7L8 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1389489:O159_RS01990 ^@ http://purl.uniprot.org/uniprot/U3P4G3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08525 ^@ http://purl.uniprot.org/uniprot/U3P8U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS09130 ^@ http://purl.uniprot.org/uniprot/U3P6T7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1389489:O159_RS03280 ^@ http://purl.uniprot.org/uniprot/U3PBP6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1389489:O159_RS02095 ^@ http://purl.uniprot.org/uniprot/U3P6X0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1389489:O159_RS08375 ^@ http://purl.uniprot.org/uniprot/U3PE94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS03350 ^@ http://purl.uniprot.org/uniprot/U3P7M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Belongs to the precorrin methyltransferase family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS07775 ^@ http://purl.uniprot.org/uniprot/U3PF48 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/1389489:O159_RS04455 ^@ http://purl.uniprot.org/uniprot/U3P6M5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS04795 ^@ http://purl.uniprot.org/uniprot/U3P4C5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1389489:O159_RS09140 ^@ http://purl.uniprot.org/uniprot/U3PBB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/1389489:O159_RS06135 ^@ http://purl.uniprot.org/uniprot/U3PD42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS08665 ^@ http://purl.uniprot.org/uniprot/U3PB26 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1389489:O159_RS08435 ^@ http://purl.uniprot.org/uniprot/U3P6E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.|||Membrane http://togogenome.org/gene/1389489:O159_RS05340 ^@ http://purl.uniprot.org/uniprot/U3P639 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/1389489:O159_RS08615 ^@ http://purl.uniprot.org/uniprot/U3PB19 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1389489:O159_RS10665 ^@ http://purl.uniprot.org/uniprot/U3P922 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1389489:O159_RS10865 ^@ http://purl.uniprot.org/uniprot/U3PCA4 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS01995 ^@ http://purl.uniprot.org/uniprot/U3P6U7 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/1389489:O159_RS04545 ^@ http://purl.uniprot.org/uniprot/U3P482 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/1389489:O159_RS12840 ^@ http://purl.uniprot.org/uniprot/U3PA42 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/1389489:O159_RS04265 ^@ http://purl.uniprot.org/uniprot/U3PC37 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS12480 ^@ http://purl.uniprot.org/uniprot/U3PD09 ^@ Function ^@ Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/1389489:O159_RS10000 ^@ http://purl.uniprot.org/uniprot/U3PBS6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1389489:O159_RS09475 ^@ http://purl.uniprot.org/uniprot/U3P8E7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/1389489:O159_RS12855 ^@ http://purl.uniprot.org/uniprot/U3PB08 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS07195 ^@ http://purl.uniprot.org/uniprot/U3P5P7 ^@ Function|||Similarity ^@ Belongs to the GlnE family.|||Involved in the regulation of glutamine synthetase GlnA, a key enzyme in the process to assimilate ammonia. When cellular nitrogen levels are high, the C-terminal adenylyl transferase (AT) inactivates GlnA by covalent transfer of an adenylyl group from ATP to specific tyrosine residue of GlnA, thus reducing its activity. Conversely, when nitrogen levels are low, the N-terminal adenylyl removase (AR) activates GlnA by removing the adenylyl group by phosphorolysis, increasing its activity. The regulatory region of GlnE binds the signal transduction protein PII (GlnB) which indicates the nitrogen status of the cell. http://togogenome.org/gene/1389489:O159_RS03085 ^@ http://purl.uniprot.org/uniprot/U3P3J8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/1389489:O159_RS03310 ^@ http://purl.uniprot.org/uniprot/U3P640 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/1389489:O159_RS12880 ^@ http://purl.uniprot.org/uniprot/U3PB13 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS02190 ^@ http://purl.uniprot.org/uniprot/U3P4J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1389489:O159_RS02235 ^@ http://purl.uniprot.org/uniprot/U3P303 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/1389489:O159_RS10820 ^@ http://purl.uniprot.org/uniprot/U3PC85 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/1389489:O159_RS04765 ^@ http://purl.uniprot.org/uniprot/U3P6T1 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/1389489:O159_RS09735 ^@ http://purl.uniprot.org/uniprot/U3PBL9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS04275 ^@ http://purl.uniprot.org/uniprot/U3P446 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02765 ^@ http://purl.uniprot.org/uniprot/U3P4V8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS00615 ^@ http://purl.uniprot.org/uniprot/U3P285 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS01930 ^@ http://purl.uniprot.org/uniprot/U3P597 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/1389489:O159_RS02420 ^@ http://purl.uniprot.org/uniprot/U3P734 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1389489:O159_RS07285 ^@ http://purl.uniprot.org/uniprot/U3PDL7 ^@ Caution|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 2 heme c groups covalently per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit. http://togogenome.org/gene/1389489:O159_RS08940 ^@ http://purl.uniprot.org/uniprot/U3PB77 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1389489:O159_RS00455 ^@ http://purl.uniprot.org/uniprot/U3P262 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02755 ^@ http://purl.uniprot.org/uniprot/U3P5R5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/1389489:O159_RS10465 ^@ http://purl.uniprot.org/uniprot/U3PC02 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1389489:O159_RS07120 ^@ http://purl.uniprot.org/uniprot/U3P720 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the MurCDEF family. MurT subfamily.|||Forms a heterodimer with GatD.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. http://togogenome.org/gene/1389489:O159_RS08985 ^@ http://purl.uniprot.org/uniprot/U3P908 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1389489:O159_RS00035 ^@ http://purl.uniprot.org/uniprot/U3P3F6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1389489:O159_RS06185 ^@ http://purl.uniprot.org/uniprot/U3P967 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/1389489:O159_RS12755 ^@ http://purl.uniprot.org/uniprot/U3PA30 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/1389489:O159_RS09110 ^@ http://purl.uniprot.org/uniprot/U3P875 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/1389489:O159_RS09720 ^@ http://purl.uniprot.org/uniprot/U3P9D0 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/1389489:O159_RS03810 ^@ http://purl.uniprot.org/uniprot/U3PBX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/1389489:O159_RS09745 ^@ http://purl.uniprot.org/uniprot/U3P9D5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/1389489:O159_RS08750 ^@ http://purl.uniprot.org/uniprot/U3P6K0 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/1389489:O159_RS09740 ^@ http://purl.uniprot.org/uniprot/U3PET5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS04105 ^@ http://purl.uniprot.org/uniprot/U3PC15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/1389489:O159_RS01515 ^@ http://purl.uniprot.org/uniprot/U3P6L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS09195 ^@ http://purl.uniprot.org/uniprot/U3PEK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS03405 ^@ http://purl.uniprot.org/uniprot/U3PBR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1389489:O159_RS00220 ^@ http://purl.uniprot.org/uniprot/U3P4H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06345 ^@ http://purl.uniprot.org/uniprot/U3PD78 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS07450 ^@ http://purl.uniprot.org/uniprot/U3P781 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1389489:O159_RS12455 ^@ http://purl.uniprot.org/uniprot/U3PD06 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS00015 ^@ http://purl.uniprot.org/uniprot/U3P5U6 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS00660 ^@ http://purl.uniprot.org/uniprot/U3P687 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS01520 ^@ http://purl.uniprot.org/uniprot/U3PAP6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/1389489:O159_RS07200 ^@ http://purl.uniprot.org/uniprot/U3P731 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1389489:O159_RS03020 ^@ http://purl.uniprot.org/uniprot/U3P7E1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1389489:O159_RS06540 ^@ http://purl.uniprot.org/uniprot/U3P6S7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1389489:O159_RS01225 ^@ http://purl.uniprot.org/uniprot/U3PAK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1389489:O159_RS08510 ^@ http://purl.uniprot.org/uniprot/U3P7W2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS08555 ^@ http://purl.uniprot.org/uniprot/U3P6G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS07350 ^@ http://purl.uniprot.org/uniprot/U3P9Y3 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08110 ^@ http://purl.uniprot.org/uniprot/U3PAJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS12040 ^@ http://purl.uniprot.org/uniprot/U3P9S0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05295 ^@ http://purl.uniprot.org/uniprot/U3P8K8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05755 ^@ http://purl.uniprot.org/uniprot/U3P7B7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS07395 ^@ http://purl.uniprot.org/uniprot/U3P772 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/1389489:O159_RS06325 ^@ http://purl.uniprot.org/uniprot/U3P7N9 ^@ Similarity ^@ Belongs to the dGTPase family. Type 2 subfamily. http://togogenome.org/gene/1389489:O159_RS09330 ^@ http://purl.uniprot.org/uniprot/U3P8B9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1389489:O159_RS00480 ^@ http://purl.uniprot.org/uniprot/U3P265 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/1389489:O159_RS03815 ^@ http://purl.uniprot.org/uniprot/U3P6B9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.|||Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS03890 ^@ http://purl.uniprot.org/uniprot/U3P5H1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1389489:O159_RS01610 ^@ http://purl.uniprot.org/uniprot/U3P4A3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS03250 ^@ http://purl.uniprot.org/uniprot/U3P7L0 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/1389489:O159_RS02970 ^@ http://purl.uniprot.org/uniprot/U3P4Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS09120 ^@ http://purl.uniprot.org/uniprot/U3PEJ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1389489:O159_RS02105 ^@ http://purl.uniprot.org/uniprot/U3P5D0 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1389489:O159_RS15810 ^@ http://purl.uniprot.org/uniprot/U3P8S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS05835 ^@ http://purl.uniprot.org/uniprot/U3P4Z9 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS05195 ^@ http://purl.uniprot.org/uniprot/U3P8I8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/1389489:O159_RS04070 ^@ http://purl.uniprot.org/uniprot/U3P7Y5 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/1389489:O159_RS07900 ^@ http://purl.uniprot.org/uniprot/U3P7G0 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/1389489:O159_RS05790 ^@ http://purl.uniprot.org/uniprot/U3P6F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS12885 ^@ http://purl.uniprot.org/uniprot/U3P8W1 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1389489:O159_RS09460 ^@ http://purl.uniprot.org/uniprot/U3PEP5 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/1389489:O159_RS00490 ^@ http://purl.uniprot.org/uniprot/U3P661 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1389489:O159_RS10790 ^@ http://purl.uniprot.org/uniprot/U3P949 ^@ Similarity ^@ Belongs to the DnaX/STICHEL family. http://togogenome.org/gene/1389489:O159_RS03670 ^@ http://purl.uniprot.org/uniprot/U3P5E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS04495 ^@ http://purl.uniprot.org/uniprot/U3P858 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/1389489:O159_RS06750 ^@ http://purl.uniprot.org/uniprot/U3P5G1 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/1389489:O159_RS05310 ^@ http://purl.uniprot.org/uniprot/U3P4L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/1389489:O159_RS06980 ^@ http://purl.uniprot.org/uniprot/U3PDH3 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/1389489:O159_RS06910 ^@ http://purl.uniprot.org/uniprot/U3P6Y8 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1389489:O159_RS05695 ^@ http://purl.uniprot.org/uniprot/U3P8S7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS04605 ^@ http://purl.uniprot.org/uniprot/U3P491 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/1389489:O159_RS02100 ^@ http://purl.uniprot.org/uniprot/U3PAY5 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/1389489:O159_RS09170 ^@ http://purl.uniprot.org/uniprot/U3PEJ8 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1389489:O159_RS04590 ^@ http://purl.uniprot.org/uniprot/U3P874 ^@ Function|||Similarity ^@ ATP-dependent carboxylate-amine ligase which exhibits weak glutamate--cysteine ligase activity.|||Belongs to the glutamate--cysteine ligase type 2 family. YbdK subfamily. http://togogenome.org/gene/1389489:O159_RS10145 ^@ http://purl.uniprot.org/uniprot/U3P9L9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1389489:O159_RS04040 ^@ http://purl.uniprot.org/uniprot/U3P5J2 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1389489:O159_RS05850 ^@ http://purl.uniprot.org/uniprot/U3PCY9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. TreS subfamily. http://togogenome.org/gene/1389489:O159_RS10920 ^@ http://purl.uniprot.org/uniprot/U3PFH1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS06860 ^@ http://purl.uniprot.org/uniprot/U3P6X9 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/1389489:O159_RS02820 ^@ http://purl.uniprot.org/uniprot/U3P5S5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS05575 ^@ http://purl.uniprot.org/uniprot/U3P784 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/1389489:O159_RS04155 ^@ http://purl.uniprot.org/uniprot/U3P7Z7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism. http://togogenome.org/gene/1389489:O159_RS09675 ^@ http://purl.uniprot.org/uniprot/U3P759 ^@ Similarity|||Subcellular Location Annotation ^@ Bacterial flagellum|||Belongs to the flagella basal body rod proteins family.|||Secreted http://togogenome.org/gene/1389489:O159_RS09515 ^@ http://purl.uniprot.org/uniprot/U3P992 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS03690 ^@ http://purl.uniprot.org/uniprot/U3P5E4 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS10495 ^@ http://purl.uniprot.org/uniprot/U3PF67 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1389489:O159_RS07405 ^@ http://purl.uniprot.org/uniprot/U3PDN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS03025 ^@ http://purl.uniprot.org/uniprot/U3PBI2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cell surface|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.|||capsule|||cell wall http://togogenome.org/gene/1389489:O159_RS07970 ^@ http://purl.uniprot.org/uniprot/U3P8I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1389489:O159_RS06025 ^@ http://purl.uniprot.org/uniprot/U3PD23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS09185 ^@ http://purl.uniprot.org/uniprot/U3P889 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1389489:O159_RS08065 ^@ http://purl.uniprot.org/uniprot/U3PE18 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1389489:O159_RS00195 ^@ http://purl.uniprot.org/uniprot/U3P4G6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS00930 ^@ http://purl.uniprot.org/uniprot/U3PAH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS10085 ^@ http://purl.uniprot.org/uniprot/U3P7C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LpqB lipoprotein family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS00815 ^@ http://purl.uniprot.org/uniprot/U3P4T0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 2 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1389489:O159_RS07375 ^@ http://purl.uniprot.org/uniprot/U3P9Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DivIVA family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS06735 ^@ http://purl.uniprot.org/uniprot/U3P9J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS10605 ^@ http://purl.uniprot.org/uniprot/U3P7N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1389489:O159_RS05940 ^@ http://purl.uniprot.org/uniprot/U3PD08 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS06790 ^@ http://purl.uniprot.org/uniprot/U3P9K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/1389489:O159_RS08540 ^@ http://purl.uniprot.org/uniprot/U3PB06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS09125 ^@ http://purl.uniprot.org/uniprot/U3P926 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1389489:O159_RS00695 ^@ http://purl.uniprot.org/uniprot/U3P690 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS01215 ^@ http://purl.uniprot.org/uniprot/U3P441 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1389489:O159_RS07305 ^@ http://purl.uniprot.org/uniprot/U3PDM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with subunits I, II and III to form cytochrome c oxidase.|||Belongs to the cytochrome c oxidase bacterial subunit CtaF family.|||Cell membrane|||Membrane|||Part of cytochrome c oxidase, its function is unknown. http://togogenome.org/gene/1389489:O159_RS08640 ^@ http://purl.uniprot.org/uniprot/U3PB23 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/1389489:O159_RS10985 ^@ http://purl.uniprot.org/uniprot/U3P998 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1389489:O159_RS05655 ^@ http://purl.uniprot.org/uniprot/U3P799 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1389489:O159_RS10590 ^@ http://purl.uniprot.org/uniprot/U3PC28 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1389489:O159_RS05515 ^@ http://purl.uniprot.org/uniprot/U3P8P5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/1389489:O159_RS10740 ^@ http://purl.uniprot.org/uniprot/U3P940 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS12845 ^@ http://purl.uniprot.org/uniprot/U3PD76 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1389489:O159_RS11200 ^@ http://purl.uniprot.org/uniprot/U3P9D4 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/1389489:O159_RS12095 ^@ http://purl.uniprot.org/uniprot/U3P8J1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06925 ^@ http://purl.uniprot.org/uniprot/U3P7Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1389489:O159_RS13035 ^@ http://purl.uniprot.org/uniprot/U3P454 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS10615 ^@ http://purl.uniprot.org/uniprot/U3PC33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1389489:O159_RS06440 ^@ http://purl.uniprot.org/uniprot/U3PD93 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/1389489:O159_RS05035 ^@ http://purl.uniprot.org/uniprot/U3P4H0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1389489:O159_RS01395 ^@ http://purl.uniprot.org/uniprot/U3P511 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/1389489:O159_RS05135 ^@ http://purl.uniprot.org/uniprot/U3P4I6 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/1389489:O159_RS09490 ^@ http://purl.uniprot.org/uniprot/U3P987 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1389489:O159_RS02225 ^@ http://purl.uniprot.org/uniprot/U3PB07 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/1389489:O159_RS01965 ^@ http://purl.uniprot.org/uniprot/U3P4F7 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS11450 ^@ http://purl.uniprot.org/uniprot/U3P9H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 13 family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS02405 ^@ http://purl.uniprot.org/uniprot/U3P5J4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1389489:O159_RS09205 ^@ http://purl.uniprot.org/uniprot/U3P6V7 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS08245 ^@ http://purl.uniprot.org/uniprot/U3P8P2 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/1389489:O159_RS11005 ^@ http://purl.uniprot.org/uniprot/U3P7Z0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS05525 ^@ http://purl.uniprot.org/uniprot/U3P774 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS01450 ^@ http://purl.uniprot.org/uniprot/U3P517 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS04445 ^@ http://purl.uniprot.org/uniprot/U3P848 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1389489:O159_RS04600 ^@ http://purl.uniprot.org/uniprot/U3P6Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A probable RNA-binding protein.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS08000 ^@ http://purl.uniprot.org/uniprot/U3P644 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/1389489:O159_RS07240 ^@ http://purl.uniprot.org/uniprot/U3P845 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS01825 ^@ http://purl.uniprot.org/uniprot/U3P2S3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1389489:O159_RS10490 ^@ http://purl.uniprot.org/uniprot/U3PC05 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1389489:O159_RS04555 ^@ http://purl.uniprot.org/uniprot/U3P870 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1389489:O159_RS08630 ^@ http://purl.uniprot.org/uniprot/U3P6I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS05250 ^@ http://purl.uniprot.org/uniprot/U3PCL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1389489:O159_RS00505 ^@ http://purl.uniprot.org/uniprot/U3P269 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS08535 ^@ http://purl.uniprot.org/uniprot/U3P7W5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DyP-type peroxidase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.|||Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact. http://togogenome.org/gene/1389489:O159_RS00085 ^@ http://purl.uniprot.org/uniprot/U3P3G7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1389489:O159_RS09845 ^@ http://purl.uniprot.org/uniprot/U3P9F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1389489:O159_RS11455 ^@ http://purl.uniprot.org/uniprot/U3PCJ9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/1389489:O159_RS06530 ^@ http://purl.uniprot.org/uniprot/U3P7S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS08810 ^@ http://purl.uniprot.org/uniprot/U3PB52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS08365 ^@ http://purl.uniprot.org/uniprot/U3P6D3 ^@ Similarity ^@ Belongs to the ketopantoate reductase family. http://togogenome.org/gene/1389489:O159_RS06450 ^@ http://purl.uniprot.org/uniprot/U3P5A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1389489:O159_RS01220 ^@ http://purl.uniprot.org/uniprot/U3P6G8 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1389489:O159_RS04515 ^@ http://purl.uniprot.org/uniprot/U3P5R1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1389489:O159_RS10725 ^@ http://purl.uniprot.org/uniprot/U3PC53 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1389489:O159_RS07075 ^@ http://purl.uniprot.org/uniprot/U3P9S6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS03270 ^@ http://purl.uniprot.org/uniprot/U3P577 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/1389489:O159_RS07855 ^@ http://purl.uniprot.org/uniprot/U3P7F1 ^@ Similarity ^@ Belongs to the HSP15 family. http://togogenome.org/gene/1389489:O159_RS02380 ^@ http://purl.uniprot.org/uniprot/U3P5J0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/1389489:O159_RS02075 ^@ http://purl.uniprot.org/uniprot/U3PAY0 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS02065 ^@ http://purl.uniprot.org/uniprot/U3P4H6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06350 ^@ http://purl.uniprot.org/uniprot/U3P7P5 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/1389489:O159_RS03560 ^@ http://purl.uniprot.org/uniprot/U3P678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS12420 ^@ http://purl.uniprot.org/uniprot/U3P8P3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/1389489:O159_RS08690 ^@ http://purl.uniprot.org/uniprot/U3PED9 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/1389489:O159_RS08585 ^@ http://purl.uniprot.org/uniprot/U3PB16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS01650 ^@ http://purl.uniprot.org/uniprot/U3P549 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/1389489:O159_RS10510 ^@ http://purl.uniprot.org/uniprot/U3P8Y6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1389489:O159_RS00020 ^@ http://purl.uniprot.org/uniprot/U3PA15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1389489:O159_RS11485 ^@ http://purl.uniprot.org/uniprot/U3PFQ0 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/1389489:O159_RS09465 ^@ http://purl.uniprot.org/uniprot/U3P984 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1389489:O159_RS12425 ^@ http://purl.uniprot.org/uniprot/U3P9Y0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1389489:O159_RS12930 ^@ http://purl.uniprot.org/uniprot/U3PGD9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/1389489:O159_RS06405 ^@ http://purl.uniprot.org/uniprot/U3P6R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS01355 ^@ http://purl.uniprot.org/uniprot/U3P6J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MgtC/SapB family.|||Membrane http://togogenome.org/gene/1389489:O159_RS10175 ^@ http://purl.uniprot.org/uniprot/U3P7E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1389489:O159_RS10720 ^@ http://purl.uniprot.org/uniprot/U3P934 ^@ Similarity ^@ Belongs to the SsuE family. http://togogenome.org/gene/1389489:O159_RS01835 ^@ http://purl.uniprot.org/uniprot/U3P6S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1389489:O159_RS01565 ^@ http://purl.uniprot.org/uniprot/U3P6M6 ^@ Similarity ^@ Belongs to the DyP-type peroxidase family. http://togogenome.org/gene/1389489:O159_RS07020 ^@ http://purl.uniprot.org/uniprot/U3P706 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/1389489:O159_RS10580 ^@ http://purl.uniprot.org/uniprot/U3P7M4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS07115 ^@ http://purl.uniprot.org/uniprot/U3P5N3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CobB/CobQ family. GatD subfamily.|||Forms a heterodimer with MurT.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. http://togogenome.org/gene/1389489:O159_RS09190 ^@ http://purl.uniprot.org/uniprot/U3PBB6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS03340 ^@ http://purl.uniprot.org/uniprot/U3P3P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS11565 ^@ http://purl.uniprot.org/uniprot/U3PCL3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/1389489:O159_RS11825 ^@ http://purl.uniprot.org/uniprot/U3PCQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS12745 ^@ http://purl.uniprot.org/uniprot/U3PAY6 ^@ Similarity ^@ Belongs to the UPF0098 family. http://togogenome.org/gene/1389489:O159_RS00610 ^@ http://purl.uniprot.org/uniprot/U3P4Q1 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/1389489:O159_RS02315 ^@ http://purl.uniprot.org/uniprot/U3P4L8 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1389489:O159_RS07430 ^@ http://purl.uniprot.org/uniprot/U3PA05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1389489:O159_RS02050 ^@ http://purl.uniprot.org/uniprot/U3PAX6 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/1389489:O159_RS03095 ^@ http://purl.uniprot.org/uniprot/U3P7I0 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1389489:O159_RS08740 ^@ http://purl.uniprot.org/uniprot/U3PEE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1389489:O159_RS07275 ^@ http://purl.uniprot.org/uniprot/U3P744 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS04450 ^@ http://purl.uniprot.org/uniprot/U3PC70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1389489:O159_RS05215 ^@ http://purl.uniprot.org/uniprot/U3P616 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1389489:O159_RS02505 ^@ http://purl.uniprot.org/uniprot/U3P5L9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1389489:O159_RS02080 ^@ http://purl.uniprot.org/uniprot/U3P5C5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/1389489:O159_RS05225 ^@ http://purl.uniprot.org/uniprot/U3PCK4 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/1389489:O159_RS03230 ^@ http://purl.uniprot.org/uniprot/U3P630 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/1389489:O159_RS04595 ^@ http://purl.uniprot.org/uniprot/U3PC87 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1389489:O159_RS12925 ^@ http://purl.uniprot.org/uniprot/U3PD92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/1389489:O159_RS01505 ^@ http://purl.uniprot.org/uniprot/U3P2M2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/1389489:O159_RS01525 ^@ http://purl.uniprot.org/uniprot/U3P530 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/1389489:O159_RS05185 ^@ http://purl.uniprot.org/uniprot/U3P4J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS08605 ^@ http://purl.uniprot.org/uniprot/U3P6H5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1389489:O159_RS08980 ^@ http://purl.uniprot.org/uniprot/U3PEH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1389489:O159_RS10620 ^@ http://purl.uniprot.org/uniprot/U3PF89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS04855 ^@ http://purl.uniprot.org/uniprot/U3P8C6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02625 ^@ http://purl.uniprot.org/uniprot/U3P379 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/1389489:O159_RS06935 ^@ http://purl.uniprot.org/uniprot/U3P6Z1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1389489:O159_RS06430 ^@ http://purl.uniprot.org/uniprot/U3P6R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS06880 ^@ http://purl.uniprot.org/uniprot/U3P5I6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1389489:O159_RS04080 ^@ http://purl.uniprot.org/uniprot/U3P6F9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/1389489:O159_RS11820 ^@ http://purl.uniprot.org/uniprot/U3P9N6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/1389489:O159_RS06260 ^@ http://purl.uniprot.org/uniprot/U3P574 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1389489:O159_RS03730 ^@ http://purl.uniprot.org/uniprot/U3PBW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1389489:O159_RS10890 ^@ http://purl.uniprot.org/uniprot/U3PCA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/1389489:O159_RS01960 ^@ http://purl.uniprot.org/uniprot/U3P2U0 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/1389489:O159_RS02990 ^@ http://purl.uniprot.org/uniprot/U3P4Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/1389489:O159_RS13515 ^@ http://purl.uniprot.org/uniprot/U3PD13 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05705 ^@ http://purl.uniprot.org/uniprot/U3P7A8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1389489:O159_RS10395 ^@ http://purl.uniprot.org/uniprot/U3PF48 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/1389489:O159_RS08635 ^@ http://purl.uniprot.org/uniprot/U3P7Y1 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/1389489:O159_RS04110 ^@ http://purl.uniprot.org/uniprot/U3P6G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/1389489:O159_RS10695 ^@ http://purl.uniprot.org/uniprot/U3PC48 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS01445 ^@ http://purl.uniprot.org/uniprot/U3PAN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS00975 ^@ http://purl.uniprot.org/uniprot/U3P6D2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05305 ^@ http://purl.uniprot.org/uniprot/U3P732 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/1389489:O159_RS10570 ^@ http://purl.uniprot.org/uniprot/U3PF81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS08700 ^@ http://purl.uniprot.org/uniprot/U3P6J3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/1389489:O159_RS10555 ^@ http://purl.uniprot.org/uniprot/U3P7L9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1389489:O159_RS10525 ^@ http://purl.uniprot.org/uniprot/U3P9U7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS07840 ^@ http://purl.uniprot.org/uniprot/U3PDX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/1389489:O159_RS05495 ^@ http://purl.uniprot.org/uniprot/U3PCQ5 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1389489:O159_RS08090 ^@ http://purl.uniprot.org/uniprot/U3PE22 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS03470 ^@ http://purl.uniprot.org/uniprot/U3P3R1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1389489:O159_RS07995 ^@ http://purl.uniprot.org/uniprot/U3P8J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS02015 ^@ http://purl.uniprot.org/uniprot/U3P4G7 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/1389489:O159_RS10030 ^@ http://purl.uniprot.org/uniprot/U3PEY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS04565 ^@ http://purl.uniprot.org/uniprot/U3P6P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1389489:O159_RS10170 ^@ http://purl.uniprot.org/uniprot/U3P9M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1389489:O159_RS05270 ^@ http://purl.uniprot.org/uniprot/U3P8K2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS01830 ^@ http://purl.uniprot.org/uniprot/U3P4D8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS05385 ^@ http://purl.uniprot.org/uniprot/U3P4N3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1389489:O159_RS01145 ^@ http://purl.uniprot.org/uniprot/U3P2G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS02865 ^@ http://purl.uniprot.org/uniprot/U3P7B4 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the nitrobindin family.|||Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.|||Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.|||Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05055 ^@ http://purl.uniprot.org/uniprot/U3P6Y9 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/1389489:O159_RS11520 ^@ http://purl.uniprot.org/uniprot/U3P9J0 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/1389489:O159_RS11515 ^@ http://purl.uniprot.org/uniprot/U3P882 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1389489:O159_RS06820 ^@ http://purl.uniprot.org/uniprot/U3PDE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS06415 ^@ http://purl.uniprot.org/uniprot/U3PD89 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/1389489:O159_RS01110 ^@ http://purl.uniprot.org/uniprot/U3P4X3 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/1389489:O159_RS01630 ^@ http://purl.uniprot.org/uniprot/U3P2P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS12805 ^@ http://purl.uniprot.org/uniprot/U3PA37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS08020 ^@ http://purl.uniprot.org/uniprot/U3P8J9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/1389489:O159_RS05675 ^@ http://purl.uniprot.org/uniprot/U3PCU4 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/1389489:O159_RS09555 ^@ http://purl.uniprot.org/uniprot/U3PEQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS07340 ^@ http://purl.uniprot.org/uniprot/U3P5S0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane|||Monomer. http://togogenome.org/gene/1389489:O159_RS01870 ^@ http://purl.uniprot.org/uniprot/U3P6S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06435 ^@ http://purl.uniprot.org/uniprot/U3P9B6 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1389489:O159_RS06315 ^@ http://purl.uniprot.org/uniprot/U3P6P4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1389489:O159_RS04490 ^@ http://purl.uniprot.org/uniprot/U3P5Q6 ^@ Similarity ^@ Belongs to the helicase family. RecG subfamily. http://togogenome.org/gene/1389489:O159_RS08160 ^@ http://purl.uniprot.org/uniprot/U3P7L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS09145 ^@ http://purl.uniprot.org/uniprot/U3PEJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/1389489:O159_RS04470 ^@ http://purl.uniprot.org/uniprot/U3P853 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS00370 ^@ http://purl.uniprot.org/uniprot/U3P3N6 ^@ Similarity ^@ Belongs to the mannitol dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS02530 ^@ http://purl.uniprot.org/uniprot/U3P364 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1389489:O159_RS04320 ^@ http://purl.uniprot.org/uniprot/U3P5N0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS05155 ^@ http://purl.uniprot.org/uniprot/U3P704 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08550 ^@ http://purl.uniprot.org/uniprot/U3P8U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS12590 ^@ http://purl.uniprot.org/uniprot/U3PA08 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS01090 ^@ http://purl.uniprot.org/uniprot/U3P425 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS12195 ^@ http://purl.uniprot.org/uniprot/U3P8K7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1389489:O159_RS07140 ^@ http://purl.uniprot.org/uniprot/U3P5N8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/1389489:O159_RS08165 ^@ http://purl.uniprot.org/uniprot/U3PAM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS12645 ^@ http://purl.uniprot.org/uniprot/U3P8S5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/1389489:O159_RS05760 ^@ http://purl.uniprot.org/uniprot/U3P4X6 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1389489:O159_RS07495 ^@ http://purl.uniprot.org/uniprot/U3P5U8 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1389489:O159_RS05210 ^@ http://purl.uniprot.org/uniprot/U3P4K0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/1389489:O159_RS05180 ^@ http://purl.uniprot.org/uniprot/U3P709 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/1389489:O159_RS05710 ^@ http://purl.uniprot.org/uniprot/U3P4V1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase-binding protein RbpA family.|||Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.|||Forms a complex with the RNAP catalytic core and with free principal sigma factors.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS05690 ^@ http://purl.uniprot.org/uniprot/U3P6B1 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS09600 ^@ http://purl.uniprot.org/uniprot/U3P8G9 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1389489:O159_RS06975 ^@ http://purl.uniprot.org/uniprot/U3P9Q4 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/1389489:O159_RS03715 ^@ http://purl.uniprot.org/uniprot/U3P5E7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/1389489:O159_RS03265 ^@ http://purl.uniprot.org/uniprot/U3P3N0 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/1389489:O159_RS04680 ^@ http://purl.uniprot.org/uniprot/U3PC98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS02280 ^@ http://purl.uniprot.org/uniprot/U3P5G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS10785 ^@ http://purl.uniprot.org/uniprot/U3P7R9 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1389489:O159_RS09945 ^@ http://purl.uniprot.org/uniprot/U3P7A4 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/1389489:O159_RS12160 ^@ http://purl.uniprot.org/uniprot/U3PAN9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06120 ^@ http://purl.uniprot.org/uniprot/U3P552 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1389489:O159_RS04260 ^@ http://purl.uniprot.org/uniprot/U3P816 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/1389489:O159_RS10460 ^@ http://purl.uniprot.org/uniprot/U3P8X2 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1389489:O159_RS12800 ^@ http://purl.uniprot.org/uniprot/U3P8V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS02880 ^@ http://purl.uniprot.org/uniprot/U3P3D0 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/1389489:O159_RS06965 ^@ http://purl.uniprot.org/uniprot/U3P5K2 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/1389489:O159_RS02320 ^@ http://purl.uniprot.org/uniprot/U3P713 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/1389489:O159_RS07335 ^@ http://purl.uniprot.org/uniprot/U3P867 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/1389489:O159_RS05820 ^@ http://purl.uniprot.org/uniprot/U3P8X3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS04525 ^@ http://purl.uniprot.org/uniprot/U3PC79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS07345 ^@ http://purl.uniprot.org/uniprot/U3P758 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1389489:O159_RS07220 ^@ http://purl.uniprot.org/uniprot/U3P5Q2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1389489:O159_RS02385 ^@ http://purl.uniprot.org/uniprot/U3P334 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/1389489:O159_RS08080 ^@ http://purl.uniprot.org/uniprot/U3P7J8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/1389489:O159_RS06475 ^@ http://purl.uniprot.org/uniprot/U3P5B2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1389489:O159_RS10140 ^@ http://purl.uniprot.org/uniprot/U3PF01 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/1389489:O159_RS06095 ^@ http://purl.uniprot.org/uniprot/U3P547 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/1389489:O159_RS02230 ^@ http://purl.uniprot.org/uniprot/U3P5F6 ^@ Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. http://togogenome.org/gene/1389489:O159_RS12000 ^@ http://purl.uniprot.org/uniprot/U3PCS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1389489:O159_RS11480 ^@ http://purl.uniprot.org/uniprot/U3PCK2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS08055 ^@ http://purl.uniprot.org/uniprot/U3P7J2 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS04370 ^@ http://purl.uniprot.org/uniprot/U3P6L3 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/1389489:O159_RS09900 ^@ http://purl.uniprot.org/uniprot/U3P793 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS08915 ^@ http://purl.uniprot.org/uniprot/U3PB76 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS05005 ^@ http://purl.uniprot.org/uniprot/U3P4G4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/1389489:O159_RS01530 ^@ http://purl.uniprot.org/uniprot/U3P2M7 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1389489:O159_RS07050 ^@ http://purl.uniprot.org/uniprot/U3P9S1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/1389489:O159_RS05685 ^@ http://purl.uniprot.org/uniprot/U3P4U7 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1389489:O159_RS06525 ^@ http://purl.uniprot.org/uniprot/U3PDA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/1389489:O159_RS04435 ^@ http://purl.uniprot.org/uniprot/U3P466 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/1389489:O159_RS07420 ^@ http://purl.uniprot.org/uniprot/U3P5T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS10050 ^@ http://purl.uniprot.org/uniprot/U3PBT4 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/1389489:O159_RS04635 ^@ http://purl.uniprot.org/uniprot/U3P6Q8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1389489:O159_RS12415 ^@ http://purl.uniprot.org/uniprot/U3PAT0 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1389489:O159_RS03390 ^@ http://purl.uniprot.org/uniprot/U3P598 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/1389489:O159_RS08030 ^@ http://purl.uniprot.org/uniprot/U3P7I8 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/1389489:O159_RS09955 ^@ http://purl.uniprot.org/uniprot/U3PBR7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Homotetramer. http://togogenome.org/gene/1389489:O159_RS08135 ^@ http://purl.uniprot.org/uniprot/U3P7L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/1389489:O159_RS03155 ^@ http://purl.uniprot.org/uniprot/U3P3L4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1389489:O159_RS12140 ^@ http://purl.uniprot.org/uniprot/U3P8K0 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1389489:O159_RS00920 ^@ http://purl.uniprot.org/uniprot/U3P401 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/1389489:O159_RS11550 ^@ http://purl.uniprot.org/uniprot/U3PAE5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/1389489:O159_RS09620 ^@ http://purl.uniprot.org/uniprot/U3P751 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1389489:O159_RS04510 ^@ http://purl.uniprot.org/uniprot/U3P477 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS03425 ^@ http://purl.uniprot.org/uniprot/U3P7N8 ^@ Similarity ^@ Belongs to the ketopantoate reductase family. http://togogenome.org/gene/1389489:O159_RS10485 ^@ http://purl.uniprot.org/uniprot/U3P8X8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1389489:O159_RS03055 ^@ http://purl.uniprot.org/uniprot/U3P5Y9 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/1389489:O159_RS07005 ^@ http://purl.uniprot.org/uniprot/U3PDH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS10520 ^@ http://purl.uniprot.org/uniprot/U3PF71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1389489:O159_RS09300 ^@ http://purl.uniprot.org/uniprot/U3P959 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1389489:O159_RS04800 ^@ http://purl.uniprot.org/uniprot/U3P5V3 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1389489:O159_RS06195 ^@ http://purl.uniprot.org/uniprot/U3P7L7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. FabH family. http://togogenome.org/gene/1389489:O159_RS06070 ^@ http://purl.uniprot.org/uniprot/U3PD29 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/1389489:O159_RS07365 ^@ http://purl.uniprot.org/uniprot/U3P5S4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1389489:O159_RS04675 ^@ http://purl.uniprot.org/uniprot/U3P890 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1389489:O159_RS03195 ^@ http://purl.uniprot.org/uniprot/U3P7K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS12025 ^@ http://purl.uniprot.org/uniprot/U3PFY9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IPP isomerase type 1 family.|||Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS12090 ^@ http://purl.uniprot.org/uniprot/U3PAM6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1389489:O159_RS04645 ^@ http://purl.uniprot.org/uniprot/U3P5S6 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/1389489:O159_RS10775 ^@ http://purl.uniprot.org/uniprot/U3PFC1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS02795 ^@ http://purl.uniprot.org/uniprot/U3P5R9 ^@ Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family. http://togogenome.org/gene/1389489:O159_RS07035 ^@ http://purl.uniprot.org/uniprot/U3P807 ^@ Function|||Subcellular Location Annotation ^@ Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.|||Membrane http://togogenome.org/gene/1389489:O159_RS05265 ^@ http://purl.uniprot.org/uniprot/U3P624 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS10980 ^@ http://purl.uniprot.org/uniprot/U3P7Y6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1389489:O159_RS05335 ^@ http://purl.uniprot.org/uniprot/U3P4M5 ^@ Function|||Similarity ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. http://togogenome.org/gene/1389489:O159_RS12440 ^@ http://purl.uniprot.org/uniprot/U3PAT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS02425 ^@ http://purl.uniprot.org/uniprot/U3PB53 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1389489:O159_RS00845 ^@ http://purl.uniprot.org/uniprot/U3P6B3 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/1389489:O159_RS05000 ^@ http://purl.uniprot.org/uniprot/U3P6Y0 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/1389489:O159_RS11885 ^@ http://purl.uniprot.org/uniprot/U3P9P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS10595 ^@ http://purl.uniprot.org/uniprot/U3PF85 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1389489:O159_RS08800 ^@ http://purl.uniprot.org/uniprot/U3P6L4 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1389489:O159_RS05555 ^@ http://purl.uniprot.org/uniprot/U3P4R6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1389489:O159_RS06300 ^@ http://purl.uniprot.org/uniprot/U3PD70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS10070 ^@ http://purl.uniprot.org/uniprot/U3PBT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1389489:O159_RS12585 ^@ http://purl.uniprot.org/uniprot/U3P8R7 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/1389489:O159_RS07380 ^@ http://purl.uniprot.org/uniprot/U3PDN4 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/1389489:O159_RS12750 ^@ http://purl.uniprot.org/uniprot/U3P8U4 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/1389489:O159_RS10545 ^@ http://purl.uniprot.org/uniprot/U3PF75 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1389489:O159_RS10610 ^@ http://purl.uniprot.org/uniprot/U3P912 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS00205 ^@ http://purl.uniprot.org/uniprot/U3P3I6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS07180 ^@ http://purl.uniprot.org/uniprot/U3P726 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS01755 ^@ http://purl.uniprot.org/uniprot/U3P572 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1389489:O159_RS04085 ^@ http://purl.uniprot.org/uniprot/U3P412 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1389489:O159_RS06355 ^@ http://purl.uniprot.org/uniprot/U3P592 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/1389489:O159_RS07465 ^@ http://purl.uniprot.org/uniprot/U3P892 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1389489:O159_RS02975 ^@ http://purl.uniprot.org/uniprot/U3P7C9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1389489:O159_RS06605 ^@ http://purl.uniprot.org/uniprot/U3PDB5 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS13325 ^@ http://purl.uniprot.org/uniprot/U3P8B0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS07890 ^@ http://purl.uniprot.org/uniprot/U3P8H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS03345 ^@ http://purl.uniprot.org/uniprot/U3P590 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Cell membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/1389489:O159_RS04720 ^@ http://purl.uniprot.org/uniprot/U3P5U2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS12900 ^@ http://purl.uniprot.org/uniprot/U3PD88 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/1389489:O159_RS01975 ^@ http://purl.uniprot.org/uniprot/U3PAW4 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS10130 ^@ http://purl.uniprot.org/uniprot/U3P7D3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS12435 ^@ http://purl.uniprot.org/uniprot/U3PG54 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/1389489:O159_RS12735 ^@ http://purl.uniprot.org/uniprot/U3PD59 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/1389489:O159_RS05375 ^@ http://purl.uniprot.org/uniprot/U3PCN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1389489:O159_RS11675 ^@ http://purl.uniprot.org/uniprot/U3PAG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS08190 ^@ http://purl.uniprot.org/uniprot/U3PE39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS09970 ^@ http://purl.uniprot.org/uniprot/U3P8N9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02710 ^@ http://purl.uniprot.org/uniprot/U3PBB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/1389489:O159_RS00420 ^@ http://purl.uniprot.org/uniprot/U3P647 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS00840 ^@ http://purl.uniprot.org/uniprot/U3P3Y7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS08610 ^@ http://purl.uniprot.org/uniprot/U3P7X7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1389489:O159_RS09820 ^@ http://purl.uniprot.org/uniprot/U3P9F0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1389489:O159_RS00100 ^@ http://purl.uniprot.org/uniprot/U3P4E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrgA family.|||Cell membrane|||Involved in cell division. http://togogenome.org/gene/1389489:O159_RS05360 ^@ http://purl.uniprot.org/uniprot/U3P4M9 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS00925 ^@ http://purl.uniprot.org/uniprot/U3P6C3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS11185 ^@ http://purl.uniprot.org/uniprot/U3PA90 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family.|||Belongs to the acyl-CoA oxidase family. http://togogenome.org/gene/1389489:O159_RS01420 ^@ http://purl.uniprot.org/uniprot/U3PAN1 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/1389489:O159_RS06410 ^@ http://purl.uniprot.org/uniprot/U3P9B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS08095 ^@ http://purl.uniprot.org/uniprot/U3P8L1 ^@ Function|||Similarity ^@ Belongs to the trehalose phosphatase family.|||Removes the phosphate from trehalose 6-phosphate to produce free trehalose. http://togogenome.org/gene/1389489:O159_RS04075 ^@ http://purl.uniprot.org/uniprot/U3PC12 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/1389489:O159_RS01120 ^@ http://purl.uniprot.org/uniprot/U3P431 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02815 ^@ http://purl.uniprot.org/uniprot/U3PBE2 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1389489:O159_RS12250 ^@ http://purl.uniprot.org/uniprot/U3PCX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Basic amino acid/polyamine antiporter (APA) (TC 2.A.3.2) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS03950 ^@ http://purl.uniprot.org/uniprot/U3P5I0 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1389489:O159_RS10895 ^@ http://purl.uniprot.org/uniprot/U3PFG6 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/1389489:O159_RS09535 ^@ http://purl.uniprot.org/uniprot/U3P996 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS10560 ^@ http://purl.uniprot.org/uniprot/U3P8Z8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS07030 ^@ http://purl.uniprot.org/uniprot/U3PDI1 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/1389489:O159_RS02525 ^@ http://purl.uniprot.org/uniprot/U3P5M4 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/1389489:O159_RS09705 ^@ http://purl.uniprot.org/uniprot/U3P8I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS05715 ^@ http://purl.uniprot.org/uniprot/U3P6B4 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/1389489:O159_RS05520 ^@ http://purl.uniprot.org/uniprot/U3PCR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/1389489:O159_RS02000 ^@ http://purl.uniprot.org/uniprot/U3PAW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS01330 ^@ http://purl.uniprot.org/uniprot/U3P501 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS05175 ^@ http://purl.uniprot.org/uniprot/U3PCJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/1389489:O159_RS06970 ^@ http://purl.uniprot.org/uniprot/U3P6Z6 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/1389489:O159_RS09210 ^@ http://purl.uniprot.org/uniprot/U3P895 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1389489:O159_RS01740 ^@ http://purl.uniprot.org/uniprot/U3P2Q9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1389489:O159_RS09765 ^@ http://purl.uniprot.org/uniprot/U3P9D9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1389489:O159_RS05390 ^@ http://purl.uniprot.org/uniprot/U3P648 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS02460 ^@ http://purl.uniprot.org/uniprot/U3P349 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS06180 ^@ http://purl.uniprot.org/uniprot/U3P6M4 ^@ Function ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/1389489:O159_RS09200 ^@ http://purl.uniprot.org/uniprot/U3P941 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/1389489:O159_RS00230 ^@ http://purl.uniprot.org/uniprot/U3P3J1 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/1389489:O159_RS09650 ^@ http://purl.uniprot.org/uniprot/U3P8H5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS02810 ^@ http://purl.uniprot.org/uniprot/U3P7A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS04045 ^@ http://purl.uniprot.org/uniprot/U3P7X8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1389489:O159_RS07170 ^@ http://purl.uniprot.org/uniprot/U3P833 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS05740 ^@ http://purl.uniprot.org/uniprot/U3P6B7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS04020 ^@ http://purl.uniprot.org/uniprot/U3P7X3 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/1389489:O159_RS06800 ^@ http://purl.uniprot.org/uniprot/U3P7X1 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1389489:O159_RS10505 ^@ http://purl.uniprot.org/uniprot/U3P7K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1389489:O159_RS09245 ^@ http://purl.uniprot.org/uniprot/U3P8A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS05165 ^@ http://purl.uniprot.org/uniprot/U3P606 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxine kinase family. PdxY subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyridoxal kinase involved in the salvage pathway of pyridoxal 5'-phosphate (PLP). Catalyzes the phosphorylation of pyridoxal to PLP. http://togogenome.org/gene/1389489:O159_RS00380 ^@ http://purl.uniprot.org/uniprot/U3PA84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS02885 ^@ http://purl.uniprot.org/uniprot/U3P4X5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1389489:O159_RS05200 ^@ http://purl.uniprot.org/uniprot/U3PCJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/1389489:O159_RS11940 ^@ http://purl.uniprot.org/uniprot/U3PCR8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS09590 ^@ http://purl.uniprot.org/uniprot/U3P9A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS10540 ^@ http://purl.uniprot.org/uniprot/U3PC16 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1389489:O159_RS03090 ^@ http://purl.uniprot.org/uniprot/U3P545 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS10825 ^@ http://purl.uniprot.org/uniprot/U3PFE2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the phosphate acetyltransferase and butyryltransferase family.|||In the N-terminal section; belongs to the CobB/CobQ family.|||Involved in acetate metabolism.|||The N-terminal region seems to be important for proper quaternary structure. The C-terminal region contains the substrate-binding site. http://togogenome.org/gene/1389489:O159_RS01455 ^@ http://purl.uniprot.org/uniprot/U3P2L3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS04480 ^@ http://purl.uniprot.org/uniprot/U3P6N0 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/1389489:O159_RS09135 ^@ http://purl.uniprot.org/uniprot/U3P880 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/1389489:O159_RS10585 ^@ http://purl.uniprot.org/uniprot/U3P906 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1389489:O159_RS05650 ^@ http://purl.uniprot.org/uniprot/U3PCT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS08075 ^@ http://purl.uniprot.org/uniprot/U3P662 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS01490 ^@ http://purl.uniprot.org/uniprot/U3P6L2 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/1389489:O159_RS07515 ^@ http://purl.uniprot.org/uniprot/U3P8A1 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/1389489:O159_RS08945 ^@ http://purl.uniprot.org/uniprot/U3PEH4 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS11845 ^@ http://purl.uniprot.org/uniprot/U3P9N8 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08355 ^@ http://purl.uniprot.org/uniprot/U3PE92 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1389489:O159_RS04955 ^@ http://purl.uniprot.org/uniprot/U3P4F4 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/1389489:O159_RS02205 ^@ http://purl.uniprot.org/uniprot/U3P5F0 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/1389489:O159_RS09030 ^@ http://purl.uniprot.org/uniprot/U3P913 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS03335 ^@ http://purl.uniprot.org/uniprot/U3P645 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1389489:O159_RS10780 ^@ http://purl.uniprot.org/uniprot/U3PA11 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. http://togogenome.org/gene/1389489:O159_RS09220 ^@ http://purl.uniprot.org/uniprot/U3PEK6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1389489:O159_RS11690 ^@ http://purl.uniprot.org/uniprot/U3P8B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS05130 ^@ http://purl.uniprot.org/uniprot/U3P700 ^@ Similarity ^@ Belongs to the intimin/invasin family. http://togogenome.org/gene/1389489:O159_RS07895 ^@ http://purl.uniprot.org/uniprot/U3P623 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS10005 ^@ http://purl.uniprot.org/uniprot/U3PEY0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1389489:O159_RS04505 ^@ http://purl.uniprot.org/uniprot/U3P6N8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1389489:O159_RS02580 ^@ http://purl.uniprot.org/uniprot/U3PB90 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/1389489:O159_RS03485 ^@ http://purl.uniprot.org/uniprot/U3PBT2 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/1389489:O159_RS05075 ^@ http://purl.uniprot.org/uniprot/U3PCH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/1389489:O159_RS04115 ^@ http://purl.uniprot.org/uniprot/U3P416 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1389489:O159_RS10075 ^@ http://purl.uniprot.org/uniprot/U3PEZ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/1389489:O159_RS00030 ^@ http://purl.uniprot.org/uniprot/U3P1U7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1389489:O159_RS07385 ^@ http://purl.uniprot.org/uniprot/U3P877 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/1389489:O159_RS02650 ^@ http://purl.uniprot.org/uniprot/U3P384 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/1389489:O159_RS01210 ^@ http://purl.uniprot.org/uniprot/U3P2H2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1389489:O159_RS06850 ^@ http://purl.uniprot.org/uniprot/U3P7Y0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/1389489:O159_RS03800 ^@ http://purl.uniprot.org/uniprot/U3P5G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1389489:O159_RS05735 ^@ http://purl.uniprot.org/uniprot/U3P4V7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 2 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/1389489:O159_RS05930 ^@ http://purl.uniprot.org/uniprot/U3P6I6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS05505 ^@ http://purl.uniprot.org/uniprot/U3P4Q4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/1389489:O159_RS01030 ^@ http://purl.uniprot.org/uniprot/U3PAI4 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/1389489:O159_RS06565 ^@ http://purl.uniprot.org/uniprot/U3P5C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS07455 ^@ http://purl.uniprot.org/uniprot/U3PA10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/1389489:O159_RS02435 ^@ http://purl.uniprot.org/uniprot/U3P345 ^@ Similarity ^@ Belongs to the IMPDH/GMPR family. http://togogenome.org/gene/1389489:O159_RS09725 ^@ http://purl.uniprot.org/uniprot/U3P764 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS12935 ^@ http://purl.uniprot.org/uniprot/U3PB21 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1389489:O159_RS10745 ^@ http://purl.uniprot.org/uniprot/U3PC59 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/1389489:O159_RS04615 ^@ http://purl.uniprot.org/uniprot/U3P5S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1389489:O159_RS05680 ^@ http://purl.uniprot.org/uniprot/U3P7A3 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/1389489:O159_RS12860 ^@ http://purl.uniprot.org/uniprot/U3P8V9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/1389489:O159_RS07150 ^@ http://purl.uniprot.org/uniprot/U3P9U4 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS09560 ^@ http://purl.uniprot.org/uniprot/U3P999 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/1389489:O159_RS10450 ^@ http://purl.uniprot.org/uniprot/U3P9T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS06845 ^@ http://purl.uniprot.org/uniprot/U3PDF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VKOR family.|||Membrane http://togogenome.org/gene/1389489:O159_RS01620 ^@ http://purl.uniprot.org/uniprot/U3PAR5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1389489:O159_RS07425 ^@ http://purl.uniprot.org/uniprot/U3P778 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS07290 ^@ http://purl.uniprot.org/uniprot/U3P856 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Cell membrane|||Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.|||Membrane http://togogenome.org/gene/1389489:O159_RS03005 ^@ http://purl.uniprot.org/uniprot/U3P5W6 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. The zinc ion is important for the structural integrity of the protein. http://togogenome.org/gene/1389489:O159_RS04995 ^@ http://purl.uniprot.org/uniprot/U3PCF9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/1389489:O159_RS09730 ^@ http://purl.uniprot.org/uniprot/U3P8I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS04685 ^@ http://purl.uniprot.org/uniprot/U3P6R9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS08060 ^@ http://purl.uniprot.org/uniprot/U3PAG6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS02825 ^@ http://purl.uniprot.org/uniprot/U3P3B8 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/1389489:O159_RS05745 ^@ http://purl.uniprot.org/uniprot/U3P8T6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/1389489:O159_RS12005 ^@ http://purl.uniprot.org/uniprot/U3PFY4 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1389489:O159_RS06915 ^@ http://purl.uniprot.org/uniprot/U3P9P1 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1389489:O159_RS06205 ^@ http://purl.uniprot.org/uniprot/U3P6M9 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1389489:O159_RS07390 ^@ http://purl.uniprot.org/uniprot/U3P5S9 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/1389489:O159_RS02010 ^@ http://purl.uniprot.org/uniprot/U3P2V3 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1389489:O159_RS01005 ^@ http://purl.uniprot.org/uniprot/U3PAI1 ^@ Similarity ^@ Belongs to the ferredoxin--NADP reductase type 1 family. http://togogenome.org/gene/1389489:O159_RS03550 ^@ http://purl.uniprot.org/uniprot/U3P7Q7 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/1389489:O159_RS06635 ^@ http://purl.uniprot.org/uniprot/U3P7T9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS00510 ^@ http://purl.uniprot.org/uniprot/U3P666 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1389489:O159_RS04790 ^@ http://purl.uniprot.org/uniprot/U3P6T6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1389489:O159_RS08010 ^@ http://purl.uniprot.org/uniprot/U3PAE7 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/1389489:O159_RS08410 ^@ http://purl.uniprot.org/uniprot/U3P6E1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS04090 ^@ http://purl.uniprot.org/uniprot/U3P5J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS04630 ^@ http://purl.uniprot.org/uniprot/U3PC92 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1389489:O159_RS00010 ^@ http://purl.uniprot.org/uniprot/U3P3F3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/1389489:O159_RS01360 ^@ http://purl.uniprot.org/uniprot/U3PAM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Cell membrane|||Mediates magnesium influx to the cytosol. http://togogenome.org/gene/1389489:O159_RS08975 ^@ http://purl.uniprot.org/uniprot/U3PB82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/1389489:O159_RS06305 ^@ http://purl.uniprot.org/uniprot/U3P7N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS11150 ^@ http://purl.uniprot.org/uniprot/U3PCE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS06875 ^@ http://purl.uniprot.org/uniprot/U3P7Y4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1389489:O159_RS03000 ^@ http://purl.uniprot.org/uniprot/U3PBH8 ^@ Cofactor|||Similarity ^@ Belongs to the nitroreductase family.|||Binds 1 FMN per subunit. http://togogenome.org/gene/1389489:O159_RS03910 ^@ http://purl.uniprot.org/uniprot/U3P3Y3 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1389489:O159_RS11715 ^@ http://purl.uniprot.org/uniprot/U3P8B7 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1389489:O159_RS00385 ^@ http://purl.uniprot.org/uniprot/U3P4M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/1389489:O159_RS07370 ^@ http://purl.uniprot.org/uniprot/U3P765 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1389489:O159_RS00295 ^@ http://purl.uniprot.org/uniprot/U3PA56 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1389489:O159_RS06360 ^@ http://purl.uniprot.org/uniprot/U3P6Q2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/1389489:O159_RS07360 ^@ http://purl.uniprot.org/uniprot/U3P873 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1389489:O159_RS08005 ^@ http://purl.uniprot.org/uniprot/U3P7I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS02275 ^@ http://purl.uniprot.org/uniprot/U3PB20 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1389489:O159_RS09585 ^@ http://purl.uniprot.org/uniprot/U3PER3 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1389489:O159_RS03070 ^@ http://purl.uniprot.org/uniprot/U3P7H4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1389489:O159_RS07260 ^@ http://purl.uniprot.org/uniprot/U3PDL5 ^@ Function ^@ Component of the dihydroxyacetone kinase complex, which is responsible for the phosphoenolpyruvate (PEP)-dependent phosphorylation of dihydroxyacetone. DhaM serves as the phosphoryl donor. Is phosphorylated by phosphoenolpyruvate in an EI- and HPr-dependent reaction, and a phosphorelay system on histidine residues finally leads to phosphoryl transfer to DhaL and dihydroxyacetone. http://togogenome.org/gene/1389489:O159_RS05550 ^@ http://purl.uniprot.org/uniprot/U3P777 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1389489:O159_RS07435 ^@ http://purl.uniprot.org/uniprot/U3PDP1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS03235 ^@ http://purl.uniprot.org/uniprot/U3P3M6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS12920 ^@ http://purl.uniprot.org/uniprot/U3PA54 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/1389489:O159_RS09750 ^@ http://purl.uniprot.org/uniprot/U3P769 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1389489:O159_RS04305 ^@ http://purl.uniprot.org/uniprot/U3PC43 ^@ Function ^@ The transhydrogenation between NADH and NADP is coupled to respiration and ATP hydrolysis and functions as a proton pump across the membrane. http://togogenome.org/gene/1389489:O159_RS02310 ^@ http://purl.uniprot.org/uniprot/U3P321 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/1389489:O159_RS07505 ^@ http://purl.uniprot.org/uniprot/U3PA27 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1389489:O159_RS03600 ^@ http://purl.uniprot.org/uniprot/U3P7R5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1389489:O159_RS06825 ^@ http://purl.uniprot.org/uniprot/U3P7X6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1389489:O159_RS07280 ^@ http://purl.uniprot.org/uniprot/U3P9W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1389489:O159_RS08515 ^@ http://purl.uniprot.org/uniprot/U3PB05 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1389489:O159_RS01500 ^@ http://purl.uniprot.org/uniprot/U3P526 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/1389489:O159_RS01590 ^@ http://purl.uniprot.org/uniprot/U3P6N1 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/1389489:O159_RS05170 ^@ http://purl.uniprot.org/uniprot/U3P8I2 ^@ Similarity ^@ In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1389489:O159_RS03505 ^@ http://purl.uniprot.org/uniprot/U3PBT5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1389489:O159_RS10565 ^@ http://purl.uniprot.org/uniprot/U3PC22 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1389489:O159_RS10470 ^@ http://purl.uniprot.org/uniprot/U3PF63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1389489:O159_RS08590 ^@ http://purl.uniprot.org/uniprot/U3PEC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane