http://togogenome.org/gene/1461582:RZ44_RS04305 ^@ http://purl.uniprot.org/uniprot/A0A078LYS7 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1461582:RZ44_RS05180 ^@ http://purl.uniprot.org/uniprot/A0A078M805 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/1461582:RZ44_RS10455 ^@ http://purl.uniprot.org/uniprot/A0A078MC07 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/1461582:RZ44_RS06560 ^@ http://purl.uniprot.org/uniprot/A0A078M5D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/1461582:RZ44_RS00420 ^@ http://purl.uniprot.org/uniprot/A0A078LY75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02270 ^@ http://purl.uniprot.org/uniprot/A0A078LW42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/1461582:RZ44_RS03920 ^@ http://purl.uniprot.org/uniprot/A0A078M1E4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS01830 ^@ http://purl.uniprot.org/uniprot/A0A078LZ72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS07280 ^@ http://purl.uniprot.org/uniprot/A0A078MB19 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS04805 ^@ http://purl.uniprot.org/uniprot/A0A078M790 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05110 ^@ http://purl.uniprot.org/uniprot/A0A078M3D1 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/1461582:RZ44_RS04495 ^@ http://purl.uniprot.org/uniprot/A0A078M4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FemABX family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS00195 ^@ http://purl.uniprot.org/uniprot/A0A078LY22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02570 ^@ http://purl.uniprot.org/uniprot/A0A078LZV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS02530 ^@ http://purl.uniprot.org/uniprot/A0A078LWF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/1461582:RZ44_RS02990 ^@ http://purl.uniprot.org/uniprot/A0A078LX18 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/1461582:RZ44_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A078M3L1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS10850 ^@ http://purl.uniprot.org/uniprot/A0A078MCF5 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/1461582:RZ44_RS05300 ^@ http://purl.uniprot.org/uniprot/A0A078M639 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. HrtA family.|||Cell membrane|||Membrane|||Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1461582:RZ44_RS10040 ^@ http://purl.uniprot.org/uniprot/A0A078MDF0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/1461582:RZ44_RS04450 ^@ http://purl.uniprot.org/uniprot/A0A078M261 ^@ Similarity ^@ Belongs to the CvfB family. http://togogenome.org/gene/1461582:RZ44_RS08090 ^@ http://purl.uniprot.org/uniprot/A0A078M4E1 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/1461582:RZ44_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A078M3V4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flotillin-like FloA family.|||Cell membrane|||Found in functional membrane microdomains (FMM) that may be equivalent to eukaryotic membrane rafts FMMs are highly dynamic and increase in number as cells age. Flotillins are thought to be important factors in membrane fluidity.|||Homooligomerizes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane raft http://togogenome.org/gene/1461582:RZ44_RS07410 ^@ http://purl.uniprot.org/uniprot/A0A078MB77 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/1461582:RZ44_RS02185 ^@ http://purl.uniprot.org/uniprot/A0A078LW14 ^@ Function|||Similarity ^@ Belongs to the BshC family.|||Involved in bacillithiol (BSH) biosynthesis. May catalyze the last step of the pathway, the addition of cysteine to glucosamine malate (GlcN-Mal) to generate BSH. http://togogenome.org/gene/1461582:RZ44_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A078M831 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS01420 ^@ http://purl.uniprot.org/uniprot/A0A078M1C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09885 ^@ http://purl.uniprot.org/uniprot/A0A078MD68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Belongs to the P-Pant transferase superfamily. Gsp/Sfp/HetI/AcpT family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/1461582:RZ44_RS06450 ^@ http://purl.uniprot.org/uniprot/A0A078M9Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/1461582:RZ44_RS08935 ^@ http://purl.uniprot.org/uniprot/A0A078M9E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/1461582:RZ44_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A078LXT8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/1461582:RZ44_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A078LX12 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06465 ^@ http://purl.uniprot.org/uniprot/A0A078M1X2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS06625 ^@ http://purl.uniprot.org/uniprot/A0A078M281 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A078M7H3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1461582:RZ44_RS00740 ^@ http://purl.uniprot.org/uniprot/A0A078LYE8 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS01365 ^@ http://purl.uniprot.org/uniprot/A0A078M331 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit A family.|||Cell membrane|||May form a heterooligomeric complex that consists of seven subunits: mnhA1, mnhB1, mnhC1, mnhD1, mnhE1, mnhF1 and mnhG1.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03815 ^@ http://purl.uniprot.org/uniprot/A0A078M5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08615 ^@ http://purl.uniprot.org/uniprot/A0A078M8Y0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/1461582:RZ44_RS04670 ^@ http://purl.uniprot.org/uniprot/A0A078M704 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS00990 ^@ http://purl.uniprot.org/uniprot/A0A078M2I6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/1461582:RZ44_RS02295 ^@ http://purl.uniprot.org/uniprot/A0A078LW54 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/1461582:RZ44_RS07995 ^@ http://purl.uniprot.org/uniprot/A0A078M7M3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/1461582:RZ44_RS09175 ^@ http://purl.uniprot.org/uniprot/A0A078M666 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02770 ^@ http://purl.uniprot.org/uniprot/A0A078M0C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Hfq family.|||Homohexamer.|||RNA chaperone that binds small regulatory RNA (sRNAs) and mRNAs to facilitate mRNA translational regulation in response to envelope stress, environmental stress and changes in metabolite concentrations. Also binds with high specificity to tRNAs. http://togogenome.org/gene/1461582:RZ44_RS07605 ^@ http://purl.uniprot.org/uniprot/A0A078MBJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A078M196 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS00855 ^@ http://purl.uniprot.org/uniprot/A0A078LV31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10010 ^@ http://purl.uniprot.org/uniprot/A0A078MDD1 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/1461582:RZ44_RS02200 ^@ http://purl.uniprot.org/uniprot/A0A078LW18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsL family.|||Cell membrane|||Essential cell division protein.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07525 ^@ http://purl.uniprot.org/uniprot/A0A078M9B4 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1461582:RZ44_RS01400 ^@ http://purl.uniprot.org/uniprot/A0A078LVG2 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/1461582:RZ44_RS06935 ^@ http://purl.uniprot.org/uniprot/A0A078M8G3 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/1461582:RZ44_RS02710 ^@ http://purl.uniprot.org/uniprot/A0A078LWN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04935 ^@ http://purl.uniprot.org/uniprot/A0A078M7N0 ^@ Function|||Similarity ^@ Belongs to the thioredoxin family.|||Component of the thioredoxin-thioredoxin reductase system. Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions. http://togogenome.org/gene/1461582:RZ44_RS10715 ^@ http://purl.uniprot.org/uniprot/A0A078MC68 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. http://togogenome.org/gene/1461582:RZ44_RS03380 ^@ http://purl.uniprot.org/uniprot/A0A078M3L5 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/1461582:RZ44_RS00515 ^@ http://purl.uniprot.org/uniprot/A0A078LYB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A078M1L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/1461582:RZ44_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A078M3J4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/1461582:RZ44_RS09785 ^@ http://purl.uniprot.org/uniprot/A0A078MAJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/1461582:RZ44_RS02120 ^@ http://purl.uniprot.org/uniprot/A0A078M1W2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04210 ^@ http://purl.uniprot.org/uniprot/A0A078M1U4 ^@ Caution|||Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.|||Belongs to the biotin--protein ligase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A078M2L8 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Interacts with CtaA.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06570 ^@ http://purl.uniprot.org/uniprot/A0A078M5E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A078M1Y9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate.|||Homohexamer; trimer of homodimers. http://togogenome.org/gene/1461582:RZ44_RS09395 ^@ http://purl.uniprot.org/uniprot/A0A078M9R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09730 ^@ http://purl.uniprot.org/uniprot/A0A078MAP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS06215 ^@ http://purl.uniprot.org/uniprot/A0A078M7A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04130 ^@ http://purl.uniprot.org/uniprot/A0A078M1R9 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/1461582:RZ44_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A078M4J6 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/1461582:RZ44_RS02755 ^@ http://purl.uniprot.org/uniprot/A0A078M2R0 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/1461582:RZ44_RS02730 ^@ http://purl.uniprot.org/uniprot/A0A078M029 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A078M227 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS02735 ^@ http://purl.uniprot.org/uniprot/A0A078M4M1 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS06045 ^@ http://purl.uniprot.org/uniprot/A0A078M4I7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pseudouridine-5'-phosphate glycosidase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.|||Homotrimer. http://togogenome.org/gene/1461582:RZ44_RS00415 ^@ http://purl.uniprot.org/uniprot/A0A078LYA0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05015 ^@ http://purl.uniprot.org/uniprot/A0A078M011 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS06000 ^@ http://purl.uniprot.org/uniprot/A0A078M945 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family. YhdE subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase that hydrolyzes dTTP and UTP. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/1461582:RZ44_RS09655 ^@ http://purl.uniprot.org/uniprot/A0A078M743 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS08585 ^@ http://purl.uniprot.org/uniprot/A0A078MD79 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/1461582:RZ44_RS08810 ^@ http://purl.uniprot.org/uniprot/A0A078MBJ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/1461582:RZ44_RS07520 ^@ http://purl.uniprot.org/uniprot/A0A078M6V4 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/1461582:RZ44_RS03065 ^@ http://purl.uniprot.org/uniprot/A0A078M501 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pantothenate synthetase family.|||Catalyzes the condensation of pantoate with beta-alanine in an ATP-dependent reaction via a pantoyl-adenylate intermediate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The reaction proceeds by a bi uni uni bi ping pong mechanism. http://togogenome.org/gene/1461582:RZ44_RS00890 ^@ http://purl.uniprot.org/uniprot/A0A078LYH5 ^@ Function ^@ May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. http://togogenome.org/gene/1461582:RZ44_RS08620 ^@ http://purl.uniprot.org/uniprot/A0A078MD96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/1461582:RZ44_RS10370 ^@ http://purl.uniprot.org/uniprot/A0A078ME19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04105 ^@ http://purl.uniprot.org/uniprot/A0A078M1Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A078M633 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/1461582:RZ44_RS03975 ^@ http://purl.uniprot.org/uniprot/A0A078M5Y2 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS08860 ^@ http://purl.uniprot.org/uniprot/A0A078MDN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/1461582:RZ44_RS01360 ^@ http://purl.uniprot.org/uniprot/A0A078LYW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit B family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00945 ^@ http://purl.uniprot.org/uniprot/A0A078M110 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/1461582:RZ44_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A078LX51 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A078M3N2 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS02820 ^@ http://purl.uniprot.org/uniprot/A0A078M376 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS04500 ^@ http://purl.uniprot.org/uniprot/A0A078M6T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FemABX family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS00900 ^@ http://purl.uniprot.org/uniprot/A0A078M0Z4 ^@ Function ^@ Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS10605 ^@ http://purl.uniprot.org/uniprot/A0A078MC91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate.|||Homodimer and homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/1461582:RZ44_RS05660 ^@ http://purl.uniprot.org/uniprot/A0A078M401 ^@ Similarity ^@ Belongs to the isochorismate synthase family. http://togogenome.org/gene/1461582:RZ44_RS03060 ^@ http://purl.uniprot.org/uniprot/A0A078M0G1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/1461582:RZ44_RS08670 ^@ http://purl.uniprot.org/uniprot/A0A078M8Z3 ^@ Similarity|||Subunit ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS10265 ^@ http://purl.uniprot.org/uniprot/A0A078MFY7 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS01525 ^@ http://purl.uniprot.org/uniprot/A0A078LYS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06990 ^@ http://purl.uniprot.org/uniprot/A0A078M8J7 ^@ Similarity ^@ Belongs to the FBPase class 3 family. http://togogenome.org/gene/1461582:RZ44_RS04385 ^@ http://purl.uniprot.org/uniprot/A0A078M6M4 ^@ Similarity ^@ Belongs to the TelA family. http://togogenome.org/gene/1461582:RZ44_RS09765 ^@ http://purl.uniprot.org/uniprot/A0A078M7A6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/1461582:RZ44_RS10895 ^@ http://purl.uniprot.org/uniprot/A0A078MCP9 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/1461582:RZ44_RS06665 ^@ http://purl.uniprot.org/uniprot/A0A078M5J1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/1461582:RZ44_RS08865 ^@ http://purl.uniprot.org/uniprot/A0A078MBL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10150 ^@ http://purl.uniprot.org/uniprot/A0A078M7X5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. Xpt subfamily.|||Converts the preformed base xanthine, a product of nucleic acid breakdown, to xanthosine 5'-monophosphate (XMP), so it can be reused for RNA or DNA synthesis.|||Cytoplasm|||Homodimer.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS03625 ^@ http://purl.uniprot.org/uniprot/A0A078LXR3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/1461582:RZ44_RS10515 ^@ http://purl.uniprot.org/uniprot/A0A078MBU6 ^@ Similarity ^@ Belongs to the peptidase M23B family. http://togogenome.org/gene/1461582:RZ44_RS02210 ^@ http://purl.uniprot.org/uniprot/A0A078M207 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05190 ^@ http://purl.uniprot.org/uniprot/A0A078M5Y8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS06355 ^@ http://purl.uniprot.org/uniprot/A0A078M9J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05415 ^@ http://purl.uniprot.org/uniprot/A0A078M682 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS08780 ^@ http://purl.uniprot.org/uniprot/A0A078M962 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/1461582:RZ44_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A078M2U4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/1461582:RZ44_RS07920 ^@ http://purl.uniprot.org/uniprot/A0A078M7M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/1461582:RZ44_RS02445 ^@ http://purl.uniprot.org/uniprot/A0A078M488 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/1461582:RZ44_RS06765 ^@ http://purl.uniprot.org/uniprot/A0A078M2G6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10670 ^@ http://purl.uniprot.org/uniprot/A0A078MCC6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/1461582:RZ44_RS10645 ^@ http://purl.uniprot.org/uniprot/A0A078MC25 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1461582:RZ44_RS06595 ^@ http://purl.uniprot.org/uniprot/A0A078M7U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FemABX family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS02590 ^@ http://purl.uniprot.org/uniprot/A0A078M2I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02525 ^@ http://purl.uniprot.org/uniprot/A0A078M4A9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/1461582:RZ44_RS03465 ^@ http://purl.uniprot.org/uniprot/A0A078M0V0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglycosylase MltG family.|||Cell membrane|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/1461582:RZ44_RS04220 ^@ http://purl.uniprot.org/uniprot/A0A078LYP3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A078LZE0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/1461582:RZ44_RS04520 ^@ http://purl.uniprot.org/uniprot/A0A078M4W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS06525 ^@ http://purl.uniprot.org/uniprot/A0A078M5C2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS09455 ^@ http://purl.uniprot.org/uniprot/A0A078MA51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05590 ^@ http://purl.uniprot.org/uniprot/A0A078M8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10770 ^@ http://purl.uniprot.org/uniprot/A0A078MGU4 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1461582:RZ44_RS02415 ^@ http://purl.uniprot.org/uniprot/A0A078M2A4 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1461582:RZ44_RS04795 ^@ http://purl.uniprot.org/uniprot/A0A078M783 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/1461582:RZ44_RS03305 ^@ http://purl.uniprot.org/uniprot/A0A078M3J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/1461582:RZ44_RS06580 ^@ http://purl.uniprot.org/uniprot/A0A078M9V5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03275 ^@ http://purl.uniprot.org/uniprot/A0A078M0W7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/1461582:RZ44_RS10255 ^@ http://purl.uniprot.org/uniprot/A0A078MBK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05710 ^@ http://purl.uniprot.org/uniprot/A0A078M0W4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS07075 ^@ http://purl.uniprot.org/uniprot/A0A078M2U9 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A078M0U8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M38 family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Catalyzes the hydrolytic cleavage of a subset of L-isoaspartyl (L-beta-aspartyl) dipeptides. Used to degrade proteins damaged by L-isoaspartyl residues formation.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03315 ^@ http://purl.uniprot.org/uniprot/A0A078M588 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09680 ^@ http://purl.uniprot.org/uniprot/A0A078MCX3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A078M1Z5 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/1461582:RZ44_RS08555 ^@ http://purl.uniprot.org/uniprot/A0A078MB71 ^@ Similarity|||Subunit ^@ Belongs to the azoreductase type 2 family.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS07725 ^@ http://purl.uniprot.org/uniprot/A0A078M9V7 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A078LZ31 ^@ Similarity ^@ Belongs to the UPF0355 family. http://togogenome.org/gene/1461582:RZ44_RS01115 ^@ http://purl.uniprot.org/uniprot/A0A078M2K5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Is also involved in protein lipoylation via its role as an octanoyl/lipoyl carrier protein intermediate.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1461582:RZ44_RS05235 ^@ http://purl.uniprot.org/uniprot/A0A078M3K9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1461582:RZ44_RS01995 ^@ http://purl.uniprot.org/uniprot/A0A078LZ56 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02075 ^@ http://purl.uniprot.org/uniprot/A0A078M3R2 ^@ Similarity ^@ Belongs to the UPF0358 family. http://togogenome.org/gene/1461582:RZ44_RS02095 ^@ http://purl.uniprot.org/uniprot/A0A078M1U9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Interacts with CtaA.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06295 ^@ http://purl.uniprot.org/uniprot/A0A078M4P0 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1461582:RZ44_RS10530 ^@ http://purl.uniprot.org/uniprot/A0A078MGH8 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/1461582:RZ44_RS07910 ^@ http://purl.uniprot.org/uniprot/A0A078M7I1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1461582:RZ44_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A078LY35 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/1461582:RZ44_RS07770 ^@ http://purl.uniprot.org/uniprot/A0A078M9Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS07965 ^@ http://purl.uniprot.org/uniprot/A0A078M7Q4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of guanine in position 535 of 16S rRNA. http://togogenome.org/gene/1461582:RZ44_RS06910 ^@ http://purl.uniprot.org/uniprot/A0A078MAJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A078M4W6 ^@ Similarity ^@ Belongs to the UDPGP type 1 family. http://togogenome.org/gene/1461582:RZ44_RS10450 ^@ http://purl.uniprot.org/uniprot/A0A078MGD9 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/1461582:RZ44_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A078M8P5 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/1461582:RZ44_RS07650 ^@ http://purl.uniprot.org/uniprot/A0A078M771 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02275 ^@ http://purl.uniprot.org/uniprot/A0A078LZP9 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1461582:RZ44_RS00710 ^@ http://purl.uniprot.org/uniprot/A0A078LYE3 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/1461582:RZ44_RS08255 ^@ http://purl.uniprot.org/uniprot/A0A078MAL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03455 ^@ http://purl.uniprot.org/uniprot/A0A078M117 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS09750 ^@ http://purl.uniprot.org/uniprot/A0A078M787 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06435 ^@ http://purl.uniprot.org/uniprot/A0A078M1V7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/1461582:RZ44_RS02675 ^@ http://purl.uniprot.org/uniprot/A0A078M045 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsK/SpoIIIE/SftA family.|||Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.|||Homohexamer. Forms a ring that surrounds DNA.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01645 ^@ http://purl.uniprot.org/uniprot/A0A078LVK0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/1461582:RZ44_RS00435 ^@ http://purl.uniprot.org/uniprot/A0A078LUV8 ^@ Function|||Similarity ^@ Belongs to the MoaB/Mog family.|||May be involved in the biosynthesis of molybdopterin. http://togogenome.org/gene/1461582:RZ44_RS00125 ^@ http://purl.uniprot.org/uniprot/A0A078M0H3 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/1461582:RZ44_RS01370 ^@ http://purl.uniprot.org/uniprot/A0A078M1B7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/1461582:RZ44_RS10815 ^@ http://purl.uniprot.org/uniprot/A0A078MER3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/1461582:RZ44_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A078M3G7 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/1461582:RZ44_RS00585 ^@ http://purl.uniprot.org/uniprot/A0A078LUY4 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/1461582:RZ44_RS00305 ^@ http://purl.uniprot.org/uniprot/A0A078M0L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Set transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08930 ^@ http://purl.uniprot.org/uniprot/A0A078MBN6 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/1461582:RZ44_RS07125 ^@ http://purl.uniprot.org/uniprot/A0A078MAT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS10435 ^@ http://purl.uniprot.org/uniprot/A0A078ME53 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/1461582:RZ44_RS10420 ^@ http://purl.uniprot.org/uniprot/A0A078MGC1 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/1461582:RZ44_RS07730 ^@ http://purl.uniprot.org/uniprot/A0A078M7E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched chain amino acid transporter family.|||Cell membrane|||Component of the transport system for branched-chain amino acids.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10595 ^@ http://purl.uniprot.org/uniprot/A0A078MEC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0316 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10665 ^@ http://purl.uniprot.org/uniprot/A0A078MC37 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1461582:RZ44_RS03400 ^@ http://purl.uniprot.org/uniprot/A0A078M3L9 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS03720 ^@ http://purl.uniprot.org/uniprot/A0A078M170 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Fur family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04095 ^@ http://purl.uniprot.org/uniprot/A0A078M689 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1461582:RZ44_RS03420 ^@ http://purl.uniprot.org/uniprot/A0A078M5C0 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1461582:RZ44_RS09690 ^@ http://purl.uniprot.org/uniprot/A0A078MEX3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS09665 ^@ http://purl.uniprot.org/uniprot/A0A078MEW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RpoE family.|||Participates in both the initiation and recycling phases of transcription. In the presence of the delta subunit, RNAP displays an increased specificity of transcription, a decreased affinity for nucleic acids, and an increased efficiency of RNA synthesis because of enhanced recycling.|||RNAP is composed of a core of 2 alpha, a beta and a beta' subunits. The core is associated with a delta subunit and one of several sigma factors. http://togogenome.org/gene/1461582:RZ44_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A078M8B9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07175 ^@ http://purl.uniprot.org/uniprot/A0A078MAW4 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/1461582:RZ44_RS08200 ^@ http://purl.uniprot.org/uniprot/A0A078MAH2 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/1461582:RZ44_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A078M9R0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS06555 ^@ http://purl.uniprot.org/uniprot/A0A078M241 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A078LYM6 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/1461582:RZ44_RS06395 ^@ http://purl.uniprot.org/uniprot/A0A078M9L9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/1461582:RZ44_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A078LYN8 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/1461582:RZ44_RS02080 ^@ http://purl.uniprot.org/uniprot/A0A078LVY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS09675 ^@ http://purl.uniprot.org/uniprot/A0A078MAC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 3B subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/1461582:RZ44_RS03945 ^@ http://purl.uniprot.org/uniprot/A0A078M1F4 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1461582:RZ44_RS05980 ^@ http://purl.uniprot.org/uniprot/A0A078M936 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS06245 ^@ http://purl.uniprot.org/uniprot/A0A078M4M2 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 9 family. http://togogenome.org/gene/1461582:RZ44_RS07685 ^@ http://purl.uniprot.org/uniprot/A0A078M765 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09010 ^@ http://purl.uniprot.org/uniprot/A0A078M9D4 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/1461582:RZ44_RS02515 ^@ http://purl.uniprot.org/uniprot/A0A078LZU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/1461582:RZ44_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A078M859 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-4 integral membrane protein family. HrtB subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (HrtA), two transmembrane proteins (HrtB) and a solute-binding protein. http://togogenome.org/gene/1461582:RZ44_RS07850 ^@ http://purl.uniprot.org/uniprot/A0A078M7F1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GdpP/PdeA phosphodiesterase family.|||Cell membrane|||For phosphodiesterase activity, probably binds 2 Mn(2+) per subunit.|||Has phosphodiesterase (PDE) activity against cyclic-di-AMP (c-di-AMP). http://togogenome.org/gene/1461582:RZ44_RS07420 ^@ http://purl.uniprot.org/uniprot/A0A078MB82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.|||Catalyzes the sodium-dependent transport of glutamate.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS00180 ^@ http://purl.uniprot.org/uniprot/A0A078LUQ6 ^@ Function ^@ Repressor of the lactose catabolism operon. Galactose-6-phosphate is the inducer. http://togogenome.org/gene/1461582:RZ44_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A078LWK3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/1461582:RZ44_RS04410 ^@ http://purl.uniprot.org/uniprot/A0A078M4P2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/1461582:RZ44_RS08815 ^@ http://purl.uniprot.org/uniprot/A0A078M971 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/1461582:RZ44_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A078M892 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1461582:RZ44_RS08280 ^@ http://purl.uniprot.org/uniprot/A0A078MCM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06290 ^@ http://purl.uniprot.org/uniprot/A0A078M7E2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04185 ^@ http://purl.uniprot.org/uniprot/A0A078M1T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS00685 ^@ http://purl.uniprot.org/uniprot/A0A078LYE0 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS10680 ^@ http://purl.uniprot.org/uniprot/A0A078MC46 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1461582:RZ44_RS01560 ^@ http://purl.uniprot.org/uniprot/A0A078M365 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/1461582:RZ44_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A078M2Z0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/1461582:RZ44_RS10035 ^@ http://purl.uniprot.org/uniprot/A0A078M7Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/1461582:RZ44_RS01380 ^@ http://purl.uniprot.org/uniprot/A0A078LYQ5 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1461582:RZ44_RS02040 ^@ http://purl.uniprot.org/uniprot/A0A078LVW6 ^@ Similarity ^@ Belongs to the UPF0637 family. http://togogenome.org/gene/1461582:RZ44_RS08680 ^@ http://purl.uniprot.org/uniprot/A0A078M8Z7 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. Can also catalyze the epimerization of carbon 2' of dihydroneopterin to dihydromonapterin. http://togogenome.org/gene/1461582:RZ44_RS08010 ^@ http://purl.uniprot.org/uniprot/A0A078M7N6 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/1461582:RZ44_RS06500 ^@ http://purl.uniprot.org/uniprot/A0A078M5A5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/1461582:RZ44_RS10725 ^@ http://purl.uniprot.org/uniprot/A0A078MGS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09375 ^@ http://purl.uniprot.org/uniprot/A0A078MCA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A078M1T6 ^@ Similarity|||Subunit ^@ Belongs to the azoreductase type 2 family.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS01080 ^@ http://purl.uniprot.org/uniprot/A0A078LYJ2 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/1461582:RZ44_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A078M158 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/1461582:RZ44_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A078LY06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07060 ^@ http://purl.uniprot.org/uniprot/A0A078M674 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS10460 ^@ http://purl.uniprot.org/uniprot/A0A078ME65 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1461582:RZ44_RS09140 ^@ http://purl.uniprot.org/uniprot/A0A078M9G7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS07120 ^@ http://purl.uniprot.org/uniprot/A0A078M2V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS02705 ^@ http://purl.uniprot.org/uniprot/A0A078M4K1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane|||This protein catalyzes the committed step to the synthesis of the acidic phospholipids. http://togogenome.org/gene/1461582:RZ44_RS01920 ^@ http://purl.uniprot.org/uniprot/A0A078LZ21 ^@ Function|||Similarity|||Subunit ^@ A non-essential component of RNA polymerase (RNAP).|||Belongs to the RNA polymerase subunit epsilon family.|||RNAP is composed of a core of 2 alpha, a beta and a beta' subunit. The core is associated with a delta subunit, and at least one of epsilon or omega. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1461582:RZ44_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A078LXL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/1461582:RZ44_RS06480 ^@ http://purl.uniprot.org/uniprot/A0A078M4Y7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/1461582:RZ44_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A078M142 ^@ Similarity ^@ Belongs to the SCO1/2 family. http://togogenome.org/gene/1461582:RZ44_RS06850 ^@ http://purl.uniprot.org/uniprot/A0A078M5U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A078M740 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/1461582:RZ44_RS08390 ^@ http://purl.uniprot.org/uniprot/A0A078M520 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10585 ^@ http://purl.uniprot.org/uniprot/A0A078MGM0 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/1461582:RZ44_RS03300 ^@ http://purl.uniprot.org/uniprot/A0A078M0N8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Essential cell division protein that coordinates cell division and chromosome segregation. The N-terminus is involved in assembly of the cell-division machinery. The C-terminus functions as a DNA motor that moves dsDNA in an ATP-dependent manner towards the dif recombination site, which is located within the replication terminus region. Required for activation of the Xer recombinase, allowing activation of chromosome unlinking by recombination.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/1461582:RZ44_RS05090 ^@ http://purl.uniprot.org/uniprot/A0A078M3A9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A078LXN5 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/1461582:RZ44_RS03755 ^@ http://purl.uniprot.org/uniprot/A0A078M5N7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS03750 ^@ http://purl.uniprot.org/uniprot/A0A078M179 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PstS family.|||Cell membrane|||Involved in the system for phosphate transport across the cytoplasmic membrane.|||Membrane|||Part of the ABC transporter complex PstSACB involved in phosphate import.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/1461582:RZ44_RS01510 ^@ http://purl.uniprot.org/uniprot/A0A078M355 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1461582:RZ44_RS00475 ^@ http://purl.uniprot.org/uniprot/A0A078M2B0 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS09925 ^@ http://purl.uniprot.org/uniprot/A0A078MFD5 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1461582:RZ44_RS09570 ^@ http://purl.uniprot.org/uniprot/A0A078MAG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A078M026 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity.|||Single-chain monomer with multiple functions. http://togogenome.org/gene/1461582:RZ44_RS10685 ^@ http://purl.uniprot.org/uniprot/A0A078MCD6 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase subunit B family. http://togogenome.org/gene/1461582:RZ44_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A078M025 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/1461582:RZ44_RS00315 ^@ http://purl.uniprot.org/uniprot/A0A078LY91 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1461582:RZ44_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A078M2D4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/1461582:RZ44_RS02025 ^@ http://purl.uniprot.org/uniprot/A0A078M3P3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1461582:RZ44_RS07915 ^@ http://purl.uniprot.org/uniprot/A0A078MA31 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/1461582:RZ44_RS09900 ^@ http://purl.uniprot.org/uniprot/A0A078MFC2 ^@ Function|||Similarity ^@ Belongs to the PemK/MazF family.|||Toxic component of a type II toxin-antitoxin (TA) system. http://togogenome.org/gene/1461582:RZ44_RS04535 ^@ http://purl.uniprot.org/uniprot/A0A078M4X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00040 ^@ http://purl.uniprot.org/uniprot/A0A078LXZ0 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/1461582:RZ44_RS06455 ^@ http://purl.uniprot.org/uniprot/A0A078M1W6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis. Some bacteria have evolved a zinc-coordinating structure that stabilizes the LID domain.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS10545 ^@ http://purl.uniprot.org/uniprot/A0A078M8N3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/1461582:RZ44_RS09850 ^@ http://purl.uniprot.org/uniprot/A0A078MAX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02000 ^@ http://purl.uniprot.org/uniprot/A0A078M3N4 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/1461582:RZ44_RS09755 ^@ http://purl.uniprot.org/uniprot/A0A078MD10 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03215 ^@ http://purl.uniprot.org/uniprot/A0A078M557 ^@ Function|||Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. http://togogenome.org/gene/1461582:RZ44_RS02550 ^@ http://purl.uniprot.org/uniprot/A0A078M4B8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/1461582:RZ44_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A078M0N1 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/1461582:RZ44_RS03910 ^@ http://purl.uniprot.org/uniprot/A0A078M469 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1461582:RZ44_RS04835 ^@ http://purl.uniprot.org/uniprot/A0A078M5F6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A078M0Q9 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/1461582:RZ44_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A078M9D9 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/1461582:RZ44_RS00805 ^@ http://purl.uniprot.org/uniprot/A0A078LV22 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/1461582:RZ44_RS09795 ^@ http://purl.uniprot.org/uniprot/A0A078M7B6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A078M3X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS07575 ^@ http://purl.uniprot.org/uniprot/A0A078M719 ^@ Similarity ^@ Belongs to the EamA transporter family. http://togogenome.org/gene/1461582:RZ44_RS05005 ^@ http://purl.uniprot.org/uniprot/A0A078M5S2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/1461582:RZ44_RS00380 ^@ http://purl.uniprot.org/uniprot/A0A078M0M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06550 ^@ http://purl.uniprot.org/uniprot/A0A078M7T2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/1461582:RZ44_RS00275 ^@ http://purl.uniprot.org/uniprot/A0A078M280 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/1461582:RZ44_RS00170 ^@ http://purl.uniprot.org/uniprot/A0A078M263 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/1461582:RZ44_RS09895 ^@ http://purl.uniprot.org/uniprot/A0A078MB07 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system. Labile antitoxin that binds to cognate MazF toxin and counteracts its endoribonuclease activity.|||Belongs to the MazE/EndoAI family. http://togogenome.org/gene/1461582:RZ44_RS06260 ^@ http://purl.uniprot.org/uniprot/A0A078M4M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03500 ^@ http://purl.uniprot.org/uniprot/A0A078M5E3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01720 ^@ http://purl.uniprot.org/uniprot/A0A078LVL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00960 ^@ http://purl.uniprot.org/uniprot/A0A078LYI9 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr). The two antagonistic activities of HprK/P are regulated by several intracellular metabolites, which change their concentration in response to the absence or presence of rapidly metabolisable carbon sources (glucose, fructose, etc.) in the growth medium. Therefore, by controlling the phosphorylation state of HPr, HPrK/P is a sensor enzyme that plays a major role in the regulation of carbon metabolism and sugar transport: it mediates carbon catabolite repression (CCR), and regulates PTS-catalyzed carbohydrate uptake and inducer exclusion.|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/1461582:RZ44_RS07860 ^@ http://purl.uniprot.org/uniprot/A0A078M7F5 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A078M3H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10280 ^@ http://purl.uniprot.org/uniprot/A0A078M887 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit.|||Cleaves the N-terminal amino acid of tripeptides.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS08140 ^@ http://purl.uniprot.org/uniprot/A0A078MCF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10620 ^@ http://purl.uniprot.org/uniprot/A0A078MEE0 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/1461582:RZ44_RS09920 ^@ http://purl.uniprot.org/uniprot/A0A078M7J3 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/1461582:RZ44_RS08535 ^@ http://purl.uniprot.org/uniprot/A0A078M8U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/1461582:RZ44_RS09280 ^@ http://purl.uniprot.org/uniprot/A0A078M9K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A078LZM9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/1461582:RZ44_RS04815 ^@ http://purl.uniprot.org/uniprot/A0A078M795 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS10915 ^@ http://purl.uniprot.org/uniprot/A0A078MH25 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A078LYI2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS10910 ^@ http://purl.uniprot.org/uniprot/A0A078M985 ^@ Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. http://togogenome.org/gene/1461582:RZ44_RS06220 ^@ http://purl.uniprot.org/uniprot/A0A078M9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0073 (Hly-III) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08465 ^@ http://purl.uniprot.org/uniprot/A0A078M568 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/1461582:RZ44_RS07815 ^@ http://purl.uniprot.org/uniprot/A0A078M9Z9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A078M323 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03155 ^@ http://purl.uniprot.org/uniprot/A0A078LX66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SbcD family.|||Heterodimer of SbcC and SbcD.|||SbcCD cleaves DNA hairpin structures. These structures can inhibit DNA replication and are intermediates in certain DNA recombination reactions. The complex acts as a 3'->5' double strand exonuclease that can open hairpins. It also has a 5' single-strand endonuclease activity. http://togogenome.org/gene/1461582:RZ44_RS00270 ^@ http://purl.uniprot.org/uniprot/A0A078LY40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS09310 ^@ http://purl.uniprot.org/uniprot/A0A078M6E8 ^@ Similarity ^@ Belongs to the creatininase superfamily. http://togogenome.org/gene/1461582:RZ44_RS00910 ^@ http://purl.uniprot.org/uniprot/A0A078LYH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/1461582:RZ44_RS09540 ^@ http://purl.uniprot.org/uniprot/A0A078MEQ9 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/1461582:RZ44_RS03085 ^@ http://purl.uniprot.org/uniprot/A0A078M0G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0291 family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10075 ^@ http://purl.uniprot.org/uniprot/A0A078MDG9 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/1461582:RZ44_RS08625 ^@ http://purl.uniprot.org/uniprot/A0A078M8Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/1461582:RZ44_RS06350 ^@ http://purl.uniprot.org/uniprot/A0A078M1R0 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/1461582:RZ44_RS02470 ^@ http://purl.uniprot.org/uniprot/A0A078M493 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1461582:RZ44_RS01915 ^@ http://purl.uniprot.org/uniprot/A0A078M1N2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An RNase that has 5'-3' exonuclease and possibly endonuclease activity. Involved in maturation of rRNA and in some organisms also mRNA maturation and/or decay.|||Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. Bacterial RNase J subfamily.|||Binds 2 Zn(2+) ions per subunit. It is not clear if Zn(2+) or Mg(2+) is physiologically important.|||Cytoplasm|||Homodimer, may be a subunit of the RNA degradosome. http://togogenome.org/gene/1461582:RZ44_RS08645 ^@ http://purl.uniprot.org/uniprot/A0A078M8Y1 ^@ Function ^@ Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence. http://togogenome.org/gene/1461582:RZ44_RS03480 ^@ http://purl.uniprot.org/uniprot/A0A078M5D7 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/1461582:RZ44_RS08975 ^@ http://purl.uniprot.org/uniprot/A0A078M9F9 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/1461582:RZ44_RS00930 ^@ http://purl.uniprot.org/uniprot/A0A078LYH4 ^@ Similarity|||Subunit ^@ Belongs to the thioredoxin family.|||Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. http://togogenome.org/gene/1461582:RZ44_RS09705 ^@ http://purl.uniprot.org/uniprot/A0A078MAM7 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/1461582:RZ44_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A078M3Y2 ^@ PTM ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/1461582:RZ44_RS08745 ^@ http://purl.uniprot.org/uniprot/A0A078MBG0 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. ClpC subfamily. http://togogenome.org/gene/1461582:RZ44_RS00440 ^@ http://purl.uniprot.org/uniprot/A0A078LYA4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/1461582:RZ44_RS05740 ^@ http://purl.uniprot.org/uniprot/A0A078M431 ^@ Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family. http://togogenome.org/gene/1461582:RZ44_RS09835 ^@ http://purl.uniprot.org/uniprot/A0A078MF72 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP). http://togogenome.org/gene/1461582:RZ44_RS05285 ^@ http://purl.uniprot.org/uniprot/A0A078M3M6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP cyclohydrolase I family. QueF type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of 7-cyano-7-deazaguanine (preQ0) to 7-aminomethyl-7-deazaguanine (preQ1).|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07330 ^@ http://purl.uniprot.org/uniprot/A0A078M6L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS08805 ^@ http://purl.uniprot.org/uniprot/A0A078MBI5 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival. http://togogenome.org/gene/1461582:RZ44_RS03960 ^@ http://purl.uniprot.org/uniprot/A0A078M1M4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1461582:RZ44_RS05935 ^@ http://purl.uniprot.org/uniprot/A0A078M8Z8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DsbB family. BdbC subfamily.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03025 ^@ http://purl.uniprot.org/uniprot/A0A078M4Y8 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/1461582:RZ44_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A078LWA9 ^@ Function|||Similarity ^@ Belongs to the asp23 family.|||May play a key role in alkaline pH tolerance. http://togogenome.org/gene/1461582:RZ44_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A078M5G7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/1461582:RZ44_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A078M735 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06545 ^@ http://purl.uniprot.org/uniprot/A0A078M5D2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/1461582:RZ44_RS03050 ^@ http://purl.uniprot.org/uniprot/A0A078M0N0 ^@ Function|||Similarity ^@ Belongs to the SELO family.|||Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr or Tyr residues of target proteins (AMPylation). http://togogenome.org/gene/1461582:RZ44_RS03410 ^@ http://purl.uniprot.org/uniprot/A0A078M3M0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05845 ^@ http://purl.uniprot.org/uniprot/A0A078M8R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/1461582:RZ44_RS08075 ^@ http://purl.uniprot.org/uniprot/A0A078M7Y4 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS05855 ^@ http://purl.uniprot.org/uniprot/A0A078M161 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A078M2J1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS03995 ^@ http://purl.uniprot.org/uniprot/A0A078M1P3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/1461582:RZ44_RS11050 ^@ http://purl.uniprot.org/uniprot/A0A078M7T5 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein ModA family. http://togogenome.org/gene/1461582:RZ44_RS08260 ^@ http://purl.uniprot.org/uniprot/A0A078MCL5 ^@ Function|||Similarity ^@ Belongs to the catalase family. HPII subfamily.|||Serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/1461582:RZ44_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A078M1P7 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS07040 ^@ http://purl.uniprot.org/uniprot/A0A078M665 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. HrtA family.|||Cell membrane|||Membrane|||Part of the ABC transporter complex hrt involved in hemin import. Responsible for energy coupling to the transport system. http://togogenome.org/gene/1461582:RZ44_RS07085 ^@ http://purl.uniprot.org/uniprot/A0A078M685 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05400 ^@ http://purl.uniprot.org/uniprot/A0A078M891 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/1461582:RZ44_RS07015 ^@ http://purl.uniprot.org/uniprot/A0A078M2T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03090 ^@ http://purl.uniprot.org/uniprot/A0A078M0P5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS07490 ^@ http://purl.uniprot.org/uniprot/A0A078M991 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06510 ^@ http://purl.uniprot.org/uniprot/A0A078M5B5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/1461582:RZ44_RS05050 ^@ http://purl.uniprot.org/uniprot/A0A078M5T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05580 ^@ http://purl.uniprot.org/uniprot/A0A078M6E0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06980 ^@ http://purl.uniprot.org/uniprot/A0A078MAN8 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/1461582:RZ44_RS09720 ^@ http://purl.uniprot.org/uniprot/A0A078M764 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/1461582:RZ44_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A078M191 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/1461582:RZ44_RS01540 ^@ http://purl.uniprot.org/uniprot/A0A078M1E3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS07285 ^@ http://purl.uniprot.org/uniprot/A0A078M6H0 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1461582:RZ44_RS03770 ^@ http://purl.uniprot.org/uniprot/A0A078M412 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/1461582:RZ44_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A078M2L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03430 ^@ http://purl.uniprot.org/uniprot/A0A078M107 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS07155 ^@ http://purl.uniprot.org/uniprot/A0A078M6B4 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02635 ^@ http://purl.uniprot.org/uniprot/A0A078LWJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/1461582:RZ44_RS02265 ^@ http://purl.uniprot.org/uniprot/A0A078M3Y7 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS01350 ^@ http://purl.uniprot.org/uniprot/A0A078LVF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit D family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01840 ^@ http://purl.uniprot.org/uniprot/A0A078M1K8 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/1461582:RZ44_RS00725 ^@ http://purl.uniprot.org/uniprot/A0A078M0V2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/1461582:RZ44_RS00800 ^@ http://purl.uniprot.org/uniprot/A0A078M0W5 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/1461582:RZ44_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A078LYU5 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/1461582:RZ44_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A078M475 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III. http://togogenome.org/gene/1461582:RZ44_RS06485 ^@ http://purl.uniprot.org/uniprot/A0A078M1Y5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/1461582:RZ44_RS03955 ^@ http://purl.uniprot.org/uniprot/A0A078M483 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetokinase family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10270 ^@ http://purl.uniprot.org/uniprot/A0A078MBL5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A078M0Z8 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids threonine, isoleucine and methionine. http://togogenome.org/gene/1461582:RZ44_RS02020 ^@ http://purl.uniprot.org/uniprot/A0A078LZ66 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A078LWE4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/1461582:RZ44_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A078LYZ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/1461582:RZ44_RS08460 ^@ http://purl.uniprot.org/uniprot/A0A078MCZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/1461582:RZ44_RS03475 ^@ http://purl.uniprot.org/uniprot/A0A078LXJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A078M668 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05100 ^@ http://purl.uniprot.org/uniprot/A0A078M5V1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03230 ^@ http://purl.uniprot.org/uniprot/A0A078M3I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06320 ^@ http://purl.uniprot.org/uniprot/A0A078M1P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03075 ^@ http://purl.uniprot.org/uniprot/A0A078M0P1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/1461582:RZ44_RS07785 ^@ http://purl.uniprot.org/uniprot/A0A078M3U6 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/1461582:RZ44_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A078M5U8 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/1461582:RZ44_RS02310 ^@ http://purl.uniprot.org/uniprot/A0A078LZK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the condensation of ribulose 5-phosphate with formaldehyde to form 3-hexulose 6-phosphate.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A078M0V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A078M898 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01600 ^@ http://purl.uniprot.org/uniprot/A0A078LYT5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/1461582:RZ44_RS06960 ^@ http://purl.uniprot.org/uniprot/A0A078M2S1 ^@ Cofactor|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/1461582:RZ44_RS04700 ^@ http://purl.uniprot.org/uniprot/A0A078M583 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CpsC/CapA family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A078M2R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/1461582:RZ44_RS03740 ^@ http://purl.uniprot.org/uniprot/A0A078M175 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/1461582:RZ44_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A078M267 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS07870 ^@ http://purl.uniprot.org/uniprot/A0A078MC16 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS07680 ^@ http://purl.uniprot.org/uniprot/A0A078M9P8 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS03335 ^@ http://purl.uniprot.org/uniprot/A0A078M0P9 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. This enzyme catalyzes the formation of pppGpp which is then hydrolyzed to form ppGpp. http://togogenome.org/gene/1461582:RZ44_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A078LZ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FemABX family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07935 ^@ http://purl.uniprot.org/uniprot/A0A078M443 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/1461582:RZ44_RS06430 ^@ http://purl.uniprot.org/uniprot/A0A078M9P4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/1461582:RZ44_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A078LVG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0344 family.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS07750 ^@ http://purl.uniprot.org/uniprot/A0A078M7F0 ^@ Similarity ^@ To bacterial alkanal monooxygenase alpha and beta chains. http://togogenome.org/gene/1461582:RZ44_RS01060 ^@ http://purl.uniprot.org/uniprot/A0A078LYL5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05355 ^@ http://purl.uniprot.org/uniprot/A0A078M658 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/1461582:RZ44_RS02465 ^@ http://purl.uniprot.org/uniprot/A0A078LZS2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/1461582:RZ44_RS08715 ^@ http://purl.uniprot.org/uniprot/A0A078M919 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MurCDEF family. MurT subfamily.|||Forms a heterodimer with GatD.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. http://togogenome.org/gene/1461582:RZ44_RS10640 ^@ http://purl.uniprot.org/uniprot/A0A078MEE9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1461582:RZ44_RS02560 ^@ http://purl.uniprot.org/uniprot/A0A078LZY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CodY family.|||Cytoplasm|||DNA-binding protein that represses the expression of many genes that are induced as cells make the transition from rapid exponential growth to stationary phase. It is a GTP-binding protein that senses the intracellular GTP concentration as an indicator of nutritional limitations. At low GTP concentration it no longer binds GTP and stop to act as a transcriptional repressor. http://togogenome.org/gene/1461582:RZ44_RS04040 ^@ http://purl.uniprot.org/uniprot/A0A078M1N9 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1461582:RZ44_RS08455 ^@ http://purl.uniprot.org/uniprot/A0A078M563 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/1461582:RZ44_RS03915 ^@ http://purl.uniprot.org/uniprot/A0A078LY99 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/1461582:RZ44_RS08210 ^@ http://purl.uniprot.org/uniprot/A0A078M4L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01240 ^@ http://purl.uniprot.org/uniprot/A0A078M2P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09725 ^@ http://purl.uniprot.org/uniprot/A0A078MEZ3 ^@ Similarity ^@ Belongs to the UPF0340 family. http://togogenome.org/gene/1461582:RZ44_RS02425 ^@ http://purl.uniprot.org/uniprot/A0A078M480 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/1461582:RZ44_RS08410 ^@ http://purl.uniprot.org/uniprot/A0A078MAW1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A078LYL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/1461582:RZ44_RS04370 ^@ http://purl.uniprot.org/uniprot/A0A078LYX0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||E2 component of the 2-oxoglutarate dehydrogenase (OGDH) complex which catalyzes the second step in the conversion of 2-oxoglutarate to succinyl-CoA and CO(2).|||Forms a 24-polypeptide structural core with octahedral symmetry. Part of the 2-oxoglutarate dehydrogenase (OGDH) complex composed of E1 (2-oxoglutarate dehydrogenase), E2 (dihydrolipoamide succinyltransferase) and E3 (dihydrolipoamide dehydrogenase); the complex contains multiple copies of the three enzymatic components (E1, E2 and E3). http://togogenome.org/gene/1461582:RZ44_RS07645 ^@ http://purl.uniprot.org/uniprot/A0A078M3G6 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1461582:RZ44_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A078LVQ0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS08110 ^@ http://purl.uniprot.org/uniprot/A0A078MAD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/1461582:RZ44_RS01405 ^@ http://purl.uniprot.org/uniprot/A0A078LYQ9 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/1461582:RZ44_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A078M2R4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family. ParE type 2 subfamily.|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1461582:RZ44_RS10125 ^@ http://purl.uniprot.org/uniprot/A0A078MBB0 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/1461582:RZ44_RS08350 ^@ http://purl.uniprot.org/uniprot/A0A078M8C5 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/1461582:RZ44_RS03255 ^@ http://purl.uniprot.org/uniprot/A0A078M3I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08070 ^@ http://purl.uniprot.org/uniprot/A0A078MAA9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/1461582:RZ44_RS09915 ^@ http://purl.uniprot.org/uniprot/A0A078MAT7 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor family.|||Negative regulator of sigma-B activity. Phosphorylates and inactivates its specific antagonist protein, RsbV. Upon phosphorylation of RsbV, RsbW is released and binds to sigma-B, thereby blocking its ability to form an RNA polymerase holoenzyme (E-sigma-B). http://togogenome.org/gene/1461582:RZ44_RS09745 ^@ http://purl.uniprot.org/uniprot/A0A078MD02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A078M531 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A078M4L6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A078M5G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/1461582:RZ44_RS01590 ^@ http://purl.uniprot.org/uniprot/A0A078M1F1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A078M4W8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS06410 ^@ http://purl.uniprot.org/uniprot/A0A078M565 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the energy-coupling factor EcfT family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane|||Transmembrane (T) component of an energy-coupling factor (ECF) ABC-transporter complex. Unlike classic ABC transporters this ECF transporter provides the energy necessary to transport a number of different substrates. http://togogenome.org/gene/1461582:RZ44_RS01895 ^@ http://purl.uniprot.org/uniprot/A0A078LZ10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06445 ^@ http://purl.uniprot.org/uniprot/A0A078M1W1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/1461582:RZ44_RS10315 ^@ http://purl.uniprot.org/uniprot/A0A078MBS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09515 ^@ http://purl.uniprot.org/uniprot/A0A078MCN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A078LZ96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/1461582:RZ44_RS09545 ^@ http://purl.uniprot.org/uniprot/A0A078MAF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS09615 ^@ http://purl.uniprot.org/uniprot/A0A078MEU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10900 ^@ http://purl.uniprot.org/uniprot/A0A078MEX2 ^@ Similarity ^@ Belongs to the UPF0421 family. http://togogenome.org/gene/1461582:RZ44_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A078M697 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS07440 ^@ http://purl.uniprot.org/uniprot/A0A078M319 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04145 ^@ http://purl.uniprot.org/uniprot/A0A078M6B2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/1461582:RZ44_RS07135 ^@ http://purl.uniprot.org/uniprot/A0A078M8Q5 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/1461582:RZ44_RS09065 ^@ http://purl.uniprot.org/uniprot/A0A078M9E6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03270 ^@ http://purl.uniprot.org/uniprot/A0A078LXB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MreD family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A078M5U6 ^@ Similarity ^@ Belongs to the pyruvate kinase family.|||In the C-terminal section; belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/1461582:RZ44_RS06240 ^@ http://purl.uniprot.org/uniprot/A0A078M7C1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1461582:RZ44_RS08755 ^@ http://purl.uniprot.org/uniprot/A0A078M947 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/1461582:RZ44_RS03440 ^@ http://purl.uniprot.org/uniprot/A0A078M112 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/1461582:RZ44_RS02100 ^@ http://purl.uniprot.org/uniprot/A0A078LZI6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Cell membrane|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/1461582:RZ44_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A078M169 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/1461582:RZ44_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A078M4C7 ^@ Subunit ^@ Homodimer; disulfide-linked, upon oxidation. 5 homodimers assemble to form a ring-like decamer. http://togogenome.org/gene/1461582:RZ44_RS04970 ^@ http://purl.uniprot.org/uniprot/A0A078M5R3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1461582:RZ44_RS08845 ^@ http://purl.uniprot.org/uniprot/A0A078M988 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1461582:RZ44_RS05975 ^@ http://purl.uniprot.org/uniprot/A0A078M1D8 ^@ Function|||Similarity ^@ Belongs to the flavin oxidoreductase frp family.|||Reduces FMN, organic nitro compounds and disulfide DTNB. Involved in maintenance of the cellular redox state and the disulfide stress response. http://togogenome.org/gene/1461582:RZ44_RS10950 ^@ http://purl.uniprot.org/uniprot/A0A078LY73 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/1461582:RZ44_RS03705 ^@ http://purl.uniprot.org/uniprot/A0A078LXX1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/1461582:RZ44_RS00480 ^@ http://purl.uniprot.org/uniprot/A0A078M0P8 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A078M750 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. ParC type 2 subfamily.|||Cell membrane|||Heterotetramer composed of ParC and ParE.|||Topoisomerase IV is essential for chromosome segregation. It relaxes supercoiled DNA. Performs the decatenation events required during the replication of a circular DNA molecule. http://togogenome.org/gene/1461582:RZ44_RS01880 ^@ http://purl.uniprot.org/uniprot/A0A078LVQ8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The phosphoryl group from phosphoenolpyruvate (PEP) is transferred to the phosphoryl carrier protein HPr by enzyme I. Phospho-HPr then transfers it to the PTS EIIA domain. http://togogenome.org/gene/1461582:RZ44_RS06440 ^@ http://purl.uniprot.org/uniprot/A0A078M4W7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/1461582:RZ44_RS00245 ^@ http://purl.uniprot.org/uniprot/A0A078LY34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family. YeeN subfamily.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10475 ^@ http://purl.uniprot.org/uniprot/A0A078MGF4 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00570 ^@ http://purl.uniprot.org/uniprot/A0A078LYA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06475 ^@ http://purl.uniprot.org/uniprot/A0A078M1X8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/1461582:RZ44_RS06255 ^@ http://purl.uniprot.org/uniprot/A0A078M9C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03365 ^@ http://purl.uniprot.org/uniprot/A0A078LXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A078M0P3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/1461582:RZ44_RS03125 ^@ http://purl.uniprot.org/uniprot/A0A078M0R0 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS07045 ^@ http://purl.uniprot.org/uniprot/A0A078MAQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC-4 integral membrane protein family. HrtB subfamily.|||Membrane|||Part of the ABC transporter complex hrt involved in hemin import. Responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (HrtA), two transmembrane proteins (HrtB) and a solute-binding protein. http://togogenome.org/gene/1461582:RZ44_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A078M584 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10660 ^@ http://purl.uniprot.org/uniprot/A0A078MEF7 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/1461582:RZ44_RS02300 ^@ http://purl.uniprot.org/uniprot/A0A078LZQ5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrK family.|||Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit.|||Heterotetramer of 2 PyrK and 2 PyrD type B subunits.|||Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+). http://togogenome.org/gene/1461582:RZ44_RS00835 ^@ http://purl.uniprot.org/uniprot/A0A078LYG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS04980 ^@ http://purl.uniprot.org/uniprot/A0A078M5R6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1461582:RZ44_RS05175 ^@ http://purl.uniprot.org/uniprot/A0A078M084 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS00840 ^@ http://purl.uniprot.org/uniprot/A0A078LYH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS02480 ^@ http://purl.uniprot.org/uniprot/A0A078LZV9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/1461582:RZ44_RS08085 ^@ http://purl.uniprot.org/uniprot/A0A078MCC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS05135 ^@ http://purl.uniprot.org/uniprot/A0A078M063 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/1461582:RZ44_RS08015 ^@ http://purl.uniprot.org/uniprot/A0A078M494 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for molybdenum; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS03460 ^@ http://purl.uniprot.org/uniprot/A0A078LXI9 ^@ Similarity ^@ Belongs to the UPF0473 family. http://togogenome.org/gene/1461582:RZ44_RS09355 ^@ http://purl.uniprot.org/uniprot/A0A078M9N9 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/1461582:RZ44_RS09620 ^@ http://purl.uniprot.org/uniprot/A0A078MA99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10700 ^@ http://purl.uniprot.org/uniprot/A0A078MC56 ^@ Similarity ^@ Belongs to the UPF0311 family. http://togogenome.org/gene/1461582:RZ44_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A078M130 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5' exoribonuclease that releases 5'-nucleoside monophosphates and is involved in maturation of structured RNAs.|||Belongs to the RNR ribonuclease family. RNase R subfamily.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07430 ^@ http://purl.uniprot.org/uniprot/A0A078M318 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/1461582:RZ44_RS07600 ^@ http://purl.uniprot.org/uniprot/A0A078M3B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09910 ^@ http://purl.uniprot.org/uniprot/A0A078MD81 ^@ Function|||Similarity ^@ Belongs to the anti-sigma-factor antagonist family.|||Positive regulator of sigma-B activity. Non-phosphorylated RsbV binds to RsbW, preventing its association with sigma-B. When phosphorylated, releases RsbW, which is then free to complex with and inactivate sigma-B. http://togogenome.org/gene/1461582:RZ44_RS02650 ^@ http://purl.uniprot.org/uniprot/A0A078M032 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/1461582:RZ44_RS08690 ^@ http://purl.uniprot.org/uniprot/A0A078MDE6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS08215 ^@ http://purl.uniprot.org/uniprot/A0A078MCJ4 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/1461582:RZ44_RS02555 ^@ http://purl.uniprot.org/uniprot/A0A078LWG2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04850 ^@ http://purl.uniprot.org/uniprot/A0A078M2Z2 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1461582:RZ44_RS03510 ^@ http://purl.uniprot.org/uniprot/A0A078M143 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/1461582:RZ44_RS10880 ^@ http://purl.uniprot.org/uniprot/A0A078MH01 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/1461582:RZ44_RS09385 ^@ http://purl.uniprot.org/uniprot/A0A078M9Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A078M034 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/1461582:RZ44_RS09770 ^@ http://purl.uniprot.org/uniprot/A0A078MF33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/1461582:RZ44_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A078M0K2 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/1461582:RZ44_RS06325 ^@ http://purl.uniprot.org/uniprot/A0A078M4Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05725 ^@ http://purl.uniprot.org/uniprot/A0A078M8K8 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/1461582:RZ44_RS04705 ^@ http://purl.uniprot.org/uniprot/A0A078M2T0 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/1461582:RZ44_RS01340 ^@ http://purl.uniprot.org/uniprot/A0A078M328 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit F family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00300 ^@ http://purl.uniprot.org/uniprot/A0A078M284 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A078M9Q7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/1461582:RZ44_RS02005 ^@ http://purl.uniprot.org/uniprot/A0A078LVV2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/1461582:RZ44_RS07865 ^@ http://purl.uniprot.org/uniprot/A0A078MA14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03580 ^@ http://purl.uniprot.org/uniprot/A0A078M173 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/1461582:RZ44_RS06805 ^@ http://purl.uniprot.org/uniprot/A0A078M879 ^@ Function ^@ May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. http://togogenome.org/gene/1461582:RZ44_RS10885 ^@ http://purl.uniprot.org/uniprot/A0A078MCP4 ^@ Similarity ^@ Belongs to the UPF0374 family. http://togogenome.org/gene/1461582:RZ44_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A078M4D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05620 ^@ http://purl.uniprot.org/uniprot/A0A078M3Y4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/1461582:RZ44_RS09825 ^@ http://purl.uniprot.org/uniprot/A0A078MAM0 ^@ Similarity ^@ Belongs to the ThiD family. http://togogenome.org/gene/1461582:RZ44_RS04440 ^@ http://purl.uniprot.org/uniprot/A0A078M6P7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00765 ^@ http://purl.uniprot.org/uniprot/A0A078LYF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07615 ^@ http://purl.uniprot.org/uniprot/A0A078M3D6 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1461582:RZ44_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A078M5B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02980 ^@ http://purl.uniprot.org/uniprot/A0A078M0D3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.|||Binds 2 Zn(2+) ions per subunit.|||Carboxylation allows a single lysine to coordinate two zinc ions.|||Catalyzes the conversion of allantoin (5-ureidohydantoin) to allantoic acid by hydrolytic cleavage of the five-member hydantoin ring.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A078M5N4 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS10870 ^@ http://purl.uniprot.org/uniprot/A0A078MGZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS00320 ^@ http://purl.uniprot.org/uniprot/A0A078LY53 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1461582:RZ44_RS07180 ^@ http://purl.uniprot.org/uniprot/A0A078M6C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08675 ^@ http://purl.uniprot.org/uniprot/A0A078M5L8 ^@ Function|||Similarity ^@ Belongs to the DHPS family.|||Catalyzes the condensation of para-aminobenzoate (pABA) with 6-hydroxymethyl-7,8-dihydropterin diphosphate (DHPt-PP) to form 7,8-dihydropteroate (H2Pte), the immediate precursor of folate derivatives. http://togogenome.org/gene/1461582:RZ44_RS03355 ^@ http://purl.uniprot.org/uniprot/A0A078LXE9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS05515 ^@ http://purl.uniprot.org/uniprot/A0A078M0M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08475 ^@ http://purl.uniprot.org/uniprot/A0A078MAZ1 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/1461582:RZ44_RS08760 ^@ http://purl.uniprot.org/uniprot/A0A078MBG6 ^@ Similarity ^@ Belongs to the ycf81 family. http://togogenome.org/gene/1461582:RZ44_RS06540 ^@ http://purl.uniprot.org/uniprot/A0A078M7S3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/1461582:RZ44_RS04265 ^@ http://purl.uniprot.org/uniprot/A0A078M6H8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A078LYK2 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/1461582:RZ44_RS08095 ^@ http://purl.uniprot.org/uniprot/A0A078MCC5 ^@ Caution|||Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1461582:RZ44_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A078LZN2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS07940 ^@ http://purl.uniprot.org/uniprot/A0A078MC48 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/1461582:RZ44_RS01665 ^@ http://purl.uniprot.org/uniprot/A0A078M1G4 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/1461582:RZ44_RS05520 ^@ http://purl.uniprot.org/uniprot/A0A078M3V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05390 ^@ http://purl.uniprot.org/uniprot/A0A078M671 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0478 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09295 ^@ http://purl.uniprot.org/uniprot/A0A078M9L4 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/1461582:RZ44_RS02880 ^@ http://purl.uniprot.org/uniprot/A0A078M4U6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07370 ^@ http://purl.uniprot.org/uniprot/A0A078M6P3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS02715 ^@ http://purl.uniprot.org/uniprot/A0A078M065 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/1461582:RZ44_RS08145 ^@ http://purl.uniprot.org/uniprot/A0A078MAF0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1461582:RZ44_RS03260 ^@ http://purl.uniprot.org/uniprot/A0A078M0M8 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS07655 ^@ http://purl.uniprot.org/uniprot/A0A078M3H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS10960 ^@ http://purl.uniprot.org/uniprot/A0A078LVJ5 ^@ Similarity ^@ Belongs to the peptidase M23B family. http://togogenome.org/gene/1461582:RZ44_RS08480 ^@ http://purl.uniprot.org/uniprot/A0A078M8K7 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/1461582:RZ44_RS03985 ^@ http://purl.uniprot.org/uniprot/A0A078M496 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1461582:RZ44_RS04250 ^@ http://purl.uniprot.org/uniprot/A0A078M6H2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecU family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Endonuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves mobile four-strand junctions by introducing symmetrical nicks in paired strands. Promotes annealing of linear ssDNA with homologous dsDNA. Required for DNA repair, homologous recombination and chromosome segregation. http://togogenome.org/gene/1461582:RZ44_RS00885 ^@ http://purl.uniprot.org/uniprot/A0A078LYG8 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/1461582:RZ44_RS04465 ^@ http://purl.uniprot.org/uniprot/A0A078M273 ^@ Similarity ^@ Belongs to the acyltransferase 3 family. http://togogenome.org/gene/1461582:RZ44_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A078M4E9 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/1461582:RZ44_RS04965 ^@ http://purl.uniprot.org/uniprot/A0A078M347 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1461582:RZ44_RS08725 ^@ http://purl.uniprot.org/uniprot/A0A078M913 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A078M1D2 ^@ Function ^@ May bind long-chain fatty acids, such as palmitate, and may play a role in lipid transport or fatty acid metabolism. http://togogenome.org/gene/1461582:RZ44_RS01355 ^@ http://purl.uniprot.org/uniprot/A0A078LYQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit C family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00745 ^@ http://purl.uniprot.org/uniprot/A0A078M2F2 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS09265 ^@ http://purl.uniprot.org/uniprot/A0A078ME09 ^@ Similarity ^@ Belongs to the diacylglycerol/lipid kinase family. http://togogenome.org/gene/1461582:RZ44_RS07980 ^@ http://purl.uniprot.org/uniprot/A0A078MA53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01870 ^@ http://purl.uniprot.org/uniprot/A0A078LZ00 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/1461582:RZ44_RS04050 ^@ http://purl.uniprot.org/uniprot/A0A078M1P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02010 ^@ http://purl.uniprot.org/uniprot/A0A078LZE5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS04950 ^@ http://purl.uniprot.org/uniprot/A0A078M346 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06265 ^@ http://purl.uniprot.org/uniprot/A0A078M1L0 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/1461582:RZ44_RS10820 ^@ http://purl.uniprot.org/uniprot/A0A078MCK7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/1461582:RZ44_RS07845 ^@ http://purl.uniprot.org/uniprot/A0A078M7J2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/1461582:RZ44_RS03055 ^@ http://purl.uniprot.org/uniprot/A0A078M3E1 ^@ Similarity ^@ Belongs to the ketopantoate reductase family. http://togogenome.org/gene/1461582:RZ44_RS06760 ^@ http://purl.uniprot.org/uniprot/A0A078MA66 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A078M5F3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS09855 ^@ http://purl.uniprot.org/uniprot/A0A078MD52 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/1461582:RZ44_RS09805 ^@ http://purl.uniprot.org/uniprot/A0A078M7C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/1461582:RZ44_RS10285 ^@ http://purl.uniprot.org/uniprot/A0A078MBE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A078M4R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A078LYT1 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the MecA family.|||Enables the recognition and targeting of unfolded and aggregated proteins to the ClpC protease or to other proteins involved in proteolysis.|||Homodimer.|||The N-terminal domain probably binds unfolded/aggregated proteins; the C-terminal domain interacts with ClpC. http://togogenome.org/gene/1461582:RZ44_RS10555 ^@ http://purl.uniprot.org/uniprot/A0A078M8P3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/1461582:RZ44_RS04915 ^@ http://purl.uniprot.org/uniprot/A0A078M329 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/1461582:RZ44_RS01035 ^@ http://purl.uniprot.org/uniprot/A0A078LYK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/1461582:RZ44_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A078M4M6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/1461582:RZ44_RS04435 ^@ http://purl.uniprot.org/uniprot/A0A078M251 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/1461582:RZ44_RS01000 ^@ http://purl.uniprot.org/uniprot/A0A078LYH9 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/1461582:RZ44_RS09340 ^@ http://purl.uniprot.org/uniprot/A0A078M9N0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09840 ^@ http://purl.uniprot.org/uniprot/A0A078MAW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family. Type 2 subfamily.|||Cell membrane|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. http://togogenome.org/gene/1461582:RZ44_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A078M8G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/1461582:RZ44_RS10705 ^@ http://purl.uniprot.org/uniprot/A0A078M8V3 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/1461582:RZ44_RS03690 ^@ http://purl.uniprot.org/uniprot/A0A078M5L5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/1461582:RZ44_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A078M406 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS03340 ^@ http://purl.uniprot.org/uniprot/A0A078M594 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS01605 ^@ http://purl.uniprot.org/uniprot/A0A078LZ07 ^@ Similarity ^@ Belongs to the 2H phosphoesterase superfamily. YjcG family. http://togogenome.org/gene/1461582:RZ44_RS07630 ^@ http://purl.uniprot.org/uniprot/A0A078M3F2 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/1461582:RZ44_RS09995 ^@ http://purl.uniprot.org/uniprot/A0A078M7M7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/1461582:RZ44_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A078LZR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/1461582:RZ44_RS06490 ^@ http://purl.uniprot.org/uniprot/A0A078M7P7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/1461582:RZ44_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A078LXZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. N-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1461582:RZ44_RS04940 ^@ http://purl.uniprot.org/uniprot/A0A078M341 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A078M3X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FtsQ/DivIB family. DivIB subfamily.|||Cell division protein that may be involved in stabilizing or promoting the assembly of the division complex.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS06370 ^@ http://purl.uniprot.org/uniprot/A0A078M9K3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1461582:RZ44_RS05960 ^@ http://purl.uniprot.org/uniprot/A0A078M744 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/1461582:RZ44_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A078LXH6 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS01235 ^@ http://purl.uniprot.org/uniprot/A0A078LYS2 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/1461582:RZ44_RS02565 ^@ http://purl.uniprot.org/uniprot/A0A078M2G9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/1461582:RZ44_RS05000 ^@ http://purl.uniprot.org/uniprot/A0A078M364 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/1461582:RZ44_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A078M5T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/1461582:RZ44_RS10425 ^@ http://purl.uniprot.org/uniprot/A0A078M8I7 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/1461582:RZ44_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A078LWH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/1461582:RZ44_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A078M7N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA which binds and tethers DNA polymerases and other proteins to the DNA. The DNA replisome complex has a single clamp-loading complex (3 tau and 1 each of delta, delta', psi and chi subunits) which binds 3 Pol III cores (1 core on the leading strand and 2 on the lagging strand) each with a beta sliding clamp dimer. Additional proteins in the replisome are other copies of gamma, psi and chi, Ssb, DNA helicase and RNA primase. http://togogenome.org/gene/1461582:RZ44_RS04380 ^@ http://purl.uniprot.org/uniprot/A0A078LYX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the branched chain amino acid transporter family.|||Cell membrane|||Component of the transport system for branched-chain amino acids.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A078M8A8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/1461582:RZ44_RS05730 ^@ http://purl.uniprot.org/uniprot/A0A078M0X6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS06520 ^@ http://purl.uniprot.org/uniprot/A0A078M212 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/1461582:RZ44_RS06230 ^@ http://purl.uniprot.org/uniprot/A0A078M7B7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Catalyzes phosphorolysis of the pyrimidine nucleosides uridine, thymidine and 2'-deoxyuridine with the formation of the corresponding pyrimidine base and ribose-1-phosphate.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS09490 ^@ http://purl.uniprot.org/uniprot/A0A078MEL4 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS11105 ^@ http://purl.uniprot.org/uniprot/A0A078LWA4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/1461582:RZ44_RS02450 ^@ http://purl.uniprot.org/uniprot/A0A078LWC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A078M1N7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/1461582:RZ44_RS08525 ^@ http://purl.uniprot.org/uniprot/A0A078M8S8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00445 ^@ http://purl.uniprot.org/uniprot/A0A078LY82 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes the insertion of molybdate into adenylated molybdopterin with the concomitant release of AMP. http://togogenome.org/gene/1461582:RZ44_RS01595 ^@ http://purl.uniprot.org/uniprot/A0A078LVJ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07890 ^@ http://purl.uniprot.org/uniprot/A0A078MA23 ^@ PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Contains an active site 4-methylidene-imidazol-5-one (MIO), which is formed autocatalytically by cyclization and dehydration of residues Ala-Ser-Gly.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03405 ^@ http://purl.uniprot.org/uniprot/A0A078M102 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/1461582:RZ44_RS00080 ^@ http://purl.uniprot.org/uniprot/A0A078LUN6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS08325 ^@ http://purl.uniprot.org/uniprot/A0A078M8B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07360 ^@ http://purl.uniprot.org/uniprot/A0A078M916 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/1461582:RZ44_RS10020 ^@ http://purl.uniprot.org/uniprot/A0A078MB56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10590 ^@ http://purl.uniprot.org/uniprot/A0A078MC83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS00950 ^@ http://purl.uniprot.org/uniprot/A0A078LV52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/1461582:RZ44_RS03845 ^@ http://purl.uniprot.org/uniprot/A0A078M5S8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/1461582:RZ44_RS08820 ^@ http://purl.uniprot.org/uniprot/A0A078M5S0 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1461582:RZ44_RS03880 ^@ http://purl.uniprot.org/uniprot/A0A078LY71 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/1461582:RZ44_RS08180 ^@ http://purl.uniprot.org/uniprot/A0A078MAF9 ^@ Function|||Similarity ^@ Abolishes the inhibitory effect of tetracyclin on protein synthesis by a non-covalent modification of the ribosomes.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/1461582:RZ44_RS05055 ^@ http://purl.uniprot.org/uniprot/A0A078M386 ^@ Similarity|||Subunit ^@ Belongs to the FPG family.|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS08050 ^@ http://purl.uniprot.org/uniprot/A0A078M4B6 ^@ Similarity ^@ Belongs to the UPF0355 family. http://togogenome.org/gene/1461582:RZ44_RS02195 ^@ http://purl.uniprot.org/uniprot/A0A078M200 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/1461582:RZ44_RS09040 ^@ http://purl.uniprot.org/uniprot/A0A078M9E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS04455 ^@ http://purl.uniprot.org/uniprot/A0A078M4S2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/1461582:RZ44_RS01190 ^@ http://purl.uniprot.org/uniprot/A0A078M2M3 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1461582:RZ44_RS03695 ^@ http://purl.uniprot.org/uniprot/A0A078LXV8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/1461582:RZ44_RS01650 ^@ http://purl.uniprot.org/uniprot/A0A078LYU2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of L-lysine to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS09435 ^@ http://purl.uniprot.org/uniprot/A0A078M6M9 ^@ Cofactor|||Function ^@ Binds 2 [4Fe-4S] clusters.|||Component of a complex that catalyzes the oxidation of glycolate to glyoxylate. http://togogenome.org/gene/1461582:RZ44_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A078M3M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09640 ^@ http://purl.uniprot.org/uniprot/A0A078MAA6 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/1461582:RZ44_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A078M3K5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02420 ^@ http://purl.uniprot.org/uniprot/A0A078LZQ6 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/1461582:RZ44_RS10445 ^@ http://purl.uniprot.org/uniprot/A0A078M8J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS00230 ^@ http://purl.uniprot.org/uniprot/A0A078M0J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS03930 ^@ http://purl.uniprot.org/uniprot/A0A078LYA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/1461582:RZ44_RS03555 ^@ http://purl.uniprot.org/uniprot/A0A078M0Z5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/1461582:RZ44_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A078M7Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal stress protein A family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A078LZK6 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/1461582:RZ44_RS08870 ^@ http://purl.uniprot.org/uniprot/A0A078M9A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/1461582:RZ44_RS06785 ^@ http://purl.uniprot.org/uniprot/A0A078M5J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01195 ^@ http://purl.uniprot.org/uniprot/A0A078M153 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/1461582:RZ44_RS10430 ^@ http://purl.uniprot.org/uniprot/A0A078MBR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS09390 ^@ http://purl.uniprot.org/uniprot/A0A078MCB5 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1461582:RZ44_RS08590 ^@ http://purl.uniprot.org/uniprot/A0A078M5I5 ^@ Function|||Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS00470 ^@ http://purl.uniprot.org/uniprot/A0A078LY87 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Monomer and homodimer. http://togogenome.org/gene/1461582:RZ44_RS06615 ^@ http://purl.uniprot.org/uniprot/A0A078M277 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/1461582:RZ44_RS01805 ^@ http://purl.uniprot.org/uniprot/A0A078M3C6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02605 ^@ http://purl.uniprot.org/uniprot/A0A078M4F2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS01675 ^@ http://purl.uniprot.org/uniprot/A0A078LYU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS04550 ^@ http://purl.uniprot.org/uniprot/A0A078M2K3 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/1461582:RZ44_RS05625 ^@ http://purl.uniprot.org/uniprot/A0A078M8G1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS03780 ^@ http://purl.uniprot.org/uniprot/A0A078M5Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02260 ^@ http://purl.uniprot.org/uniprot/A0A078LZH7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS06285 ^@ http://purl.uniprot.org/uniprot/A0A078M4Z5 ^@ Similarity ^@ Belongs to the RNase H family. http://togogenome.org/gene/1461582:RZ44_RS10635 ^@ http://purl.uniprot.org/uniprot/A0A078MCA7 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/1461582:RZ44_RS09480 ^@ http://purl.uniprot.org/uniprot/A0A078MA13 ^@ Similarity ^@ In the C-terminal section; belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS01105 ^@ http://purl.uniprot.org/uniprot/A0A078LYJ7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type-I 3-dehydroquinase family.|||Homodimer.|||Involved in the third step of the chorismate pathway, which leads to the biosynthesis of aromatic amino acids. Catalyzes the cis-dehydration of 3-dehydroquinate (DHQ) and introduces the first double bond of the aromatic ring to yield 3-dehydroshikimate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS09160 ^@ http://purl.uniprot.org/uniprot/A0A078M660 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09685 ^@ http://purl.uniprot.org/uniprot/A0A078MAL7 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/1461582:RZ44_RS06415 ^@ http://purl.uniprot.org/uniprot/A0A078M7L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding (A) component of a common energy-coupling factor (ECF) ABC-transporter complex.|||Belongs to the ABC transporter superfamily. Energy-coupling factor EcfA family.|||Cell membrane|||Forms a stable energy-coupling factor (ECF) transporter complex composed of 2 membrane-embedded substrate-binding proteins (S component), 2 ATP-binding proteins (A component) and 2 transmembrane proteins (T component).|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01385 ^@ http://purl.uniprot.org/uniprot/A0A078LYW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. OAT subfamily.|||Catalyzes the interconversion of ornithine to glutamate semialdehyde.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10710 ^@ http://purl.uniprot.org/uniprot/A0A078MGS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS08605 ^@ http://purl.uniprot.org/uniprot/A0A078MB88 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00065 ^@ http://purl.uniprot.org/uniprot/A0A078LXZ4 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/1461582:RZ44_RS02520 ^@ http://purl.uniprot.org/uniprot/A0A078LZX3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/1461582:RZ44_RS07955 ^@ http://purl.uniprot.org/uniprot/A0A078M7P9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS04425 ^@ http://purl.uniprot.org/uniprot/A0A078M6P0 ^@ Function|||Similarity ^@ Belongs to the transferase hexapeptide repeat family. DapH subfamily.|||Catalyzes the transfer of an acetyl group from acetyl-CoA to tetrahydrodipicolinate. http://togogenome.org/gene/1461582:RZ44_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A078M2K1 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/1461582:RZ44_RS01615 ^@ http://purl.uniprot.org/uniprot/A0A078M1F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04400 ^@ http://purl.uniprot.org/uniprot/A0A078M222 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS08665 ^@ http://purl.uniprot.org/uniprot/A0A078MBB9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/1461582:RZ44_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A078M4D3 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/1461582:RZ44_RS07385 ^@ http://purl.uniprot.org/uniprot/A0A078M930 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Glutamine synthetase (GS) is an unusual multitasking protein that functions as an enzyme, a transcription coregulator, and a chaperone in ammonium assimilation and in the regulation of genes involved in nitrogen metabolism. It catalyzes the ATP-dependent biosynthesis of glutamine from glutamate and ammonia. Feedback-inhibited GlnA also interacts with and regulates the activity of the transcriptional regulator TnrA. During nitrogen limitation, TnrA is in its DNA-binding active state and turns on the transcription of genes required for nitrogen assimilation. Under conditions of nitrogen excess, feedback-inhibited GlnA forms a stable complex with TnrA, which inhibits its DNA-binding activity. In contrast, feedback-inhibited GlnA acts as a chaperone to stabilize the DNA-binding activity of GlnR, which represses the transcription of nitrogen assimilation genes.|||Oligomer of 12 subunits arranged in the form of two hexagons. In its feedback-inhibited form, interacts with TnrA in order to block its DNA-binding activity. http://togogenome.org/gene/1461582:RZ44_RS05505 ^@ http://purl.uniprot.org/uniprot/A0A078M3U8 ^@ Cofactor ^@ Binds 1 FAD per subunit. http://togogenome.org/gene/1461582:RZ44_RS04030 ^@ http://purl.uniprot.org/uniprot/A0A078M1V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ScpA family.|||Component of a cohesin-like complex composed of ScpA, ScpB and the Smc homodimer, in which ScpA and ScpB bind to the head domain of Smc. The presence of the three proteins is required for the association of the complex with DNA.|||Cytoplasm|||Participates in chromosomal partition during cell division. May act via the formation of a condensin-like complex containing Smc and ScpB that pull DNA away from mid-cell into both cell halves. http://togogenome.org/gene/1461582:RZ44_RS07960 ^@ http://purl.uniprot.org/uniprot/A0A078M460 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/1461582:RZ44_RS00770 ^@ http://purl.uniprot.org/uniprot/A0A078M2F6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A078M6G3 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. MenE subfamily.|||Converts 2-succinylbenzoate (OSB) to 2-succinylbenzoyl-CoA (OSB-CoA). http://togogenome.org/gene/1461582:RZ44_RS01270 ^@ http://purl.uniprot.org/uniprot/A0A078M1A1 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/1461582:RZ44_RS04890 ^@ http://purl.uniprot.org/uniprot/A0A078M304 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/1461582:RZ44_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A078M3B9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS09700 ^@ http://purl.uniprot.org/uniprot/A0A078MEY1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/1461582:RZ44_RS03095 ^@ http://purl.uniprot.org/uniprot/A0A078M3F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0154 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09445 ^@ http://purl.uniprot.org/uniprot/A0A078M6N9 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS01485 ^@ http://purl.uniprot.org/uniprot/A0A078M353 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/1461582:RZ44_RS02440 ^@ http://purl.uniprot.org/uniprot/A0A078LZU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsX family.|||Catalyzes the reversible formation of acyl-phosphate (acyl-PO(4)) from acyl-[acyl-carrier-protein] (acyl-ACP). This enzyme utilizes acyl-ACP as fatty acyl donor, but not acyl-CoA.|||Cytoplasm|||Homodimer. Probably interacts with PlsY. http://togogenome.org/gene/1461582:RZ44_RS10140 ^@ http://purl.uniprot.org/uniprot/A0A078MDJ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/1461582:RZ44_RS08950 ^@ http://purl.uniprot.org/uniprot/A0A078M9F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0382 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A078M237 ^@ Function|||Similarity|||Subunit ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Homodimer and homohexamer; in equilibrium.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi.|||Regulates transcriptional attenuation of the pyrimidine nucleotide (pyr) operon by binding in a uridine-dependent manner to specific sites on pyr mRNA. This disrupts an antiterminator hairpin in the RNA and favors formation of a downstream transcription terminator, leading to a reduced expression of downstream genes. http://togogenome.org/gene/1461582:RZ44_RS00920 ^@ http://purl.uniprot.org/uniprot/A0A078M2H8 ^@ PTM ^@ Binds 1 heme c group covalently per subunit. http://togogenome.org/gene/1461582:RZ44_RS09330 ^@ http://purl.uniprot.org/uniprot/A0A078ME42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TenA family.|||Catalyzes an amino-pyrimidine hydrolysis reaction at the C5' of the pyrimidine moiety of thiamine compounds, a reaction that is part of a thiamine salvage pathway.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS01250 ^@ http://purl.uniprot.org/uniprot/A0A078LVC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0014 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02455 ^@ http://purl.uniprot.org/uniprot/A0A078LZV1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS04720 ^@ http://purl.uniprot.org/uniprot/A0A078LZF3 ^@ Similarity ^@ Belongs to the PemK/MazF family. http://togogenome.org/gene/1461582:RZ44_RS08340 ^@ http://purl.uniprot.org/uniprot/A0A078M4W9 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/1461582:RZ44_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A078M2E2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/1461582:RZ44_RS04295 ^@ http://purl.uniprot.org/uniprot/A0A078M1X7 ^@ Similarity ^@ Belongs to the UPF0403 family. http://togogenome.org/gene/1461582:RZ44_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A078M0T6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS09990 ^@ http://purl.uniprot.org/uniprot/A0A078MAX5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/1461582:RZ44_RS02085 ^@ http://purl.uniprot.org/uniprot/A0A078LZA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS03225 ^@ http://purl.uniprot.org/uniprot/A0A078M0U6 ^@ Function|||Similarity ^@ Belongs to the nitronate monooxygenase family. NMO class I subfamily.|||Nitronate monooxygenase that uses molecular oxygen to catalyze the oxidative denitrification of alkyl nitronates. Acts on propionate 3-nitronate (P3N), the presumed physiological substrate. Probably functions in the detoxification of P3N, a metabolic poison produced by plants and fungi as a defense mechanism. http://togogenome.org/gene/1461582:RZ44_RS01990 ^@ http://purl.uniprot.org/uniprot/A0A078M1R1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A078M1B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CPA3 antiporters (TC 2.A.63) subunit E family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07065 ^@ http://purl.uniprot.org/uniprot/A0A078M8N2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10905 ^@ http://purl.uniprot.org/uniprot/A0A078MCI9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS00995 ^@ http://purl.uniprot.org/uniprot/A0A078M118 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/1461582:RZ44_RS03595 ^@ http://purl.uniprot.org/uniprot/A0A078M5H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03210 ^@ http://purl.uniprot.org/uniprot/A0A078M0L2 ^@ Similarity ^@ Belongs to the SorC transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A078M4H4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS03925 ^@ http://purl.uniprot.org/uniprot/A0A078M5W0 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/1461582:RZ44_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A078M2F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. DIT1 subfamily.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02775 ^@ http://purl.uniprot.org/uniprot/A0A078M4Q3 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/1461582:RZ44_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A078M598 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS02975 ^@ http://purl.uniprot.org/uniprot/A0A078LX15 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/1461582:RZ44_RS08905 ^@ http://purl.uniprot.org/uniprot/A0A078MBM6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS07745 ^@ http://purl.uniprot.org/uniprot/A0A078M3R6 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1461582:RZ44_RS02350 ^@ http://purl.uniprot.org/uniprot/A0A078LZR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Cytoplasm|||Specifically methylates the cytosine at position 967 (m5C967) of 16S rRNA. http://togogenome.org/gene/1461582:RZ44_RS07240 ^@ http://purl.uniprot.org/uniprot/A0A078M6F5 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/1461582:RZ44_RS01090 ^@ http://purl.uniprot.org/uniprot/A0A078M2K0 ^@ Similarity ^@ Belongs to the UPF0337 (CsbD) family. http://togogenome.org/gene/1461582:RZ44_RS06630 ^@ http://purl.uniprot.org/uniprot/A0A078M9X5 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/1461582:RZ44_RS06330 ^@ http://purl.uniprot.org/uniprot/A0A078M1Q1 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/1461582:RZ44_RS06005 ^@ http://purl.uniprot.org/uniprot/A0A078M1E8 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/1461582:RZ44_RS09930 ^@ http://purl.uniprot.org/uniprot/A0A078MB26 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/1461582:RZ44_RS00985 ^@ http://purl.uniprot.org/uniprot/A0A078LYJ5 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/1461582:RZ44_RS01325 ^@ http://purl.uniprot.org/uniprot/A0A078LVF3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/1461582:RZ44_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A078LZ84 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/1461582:RZ44_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A078LYD0 ^@ Similarity ^@ Belongs to the UPF0403 family. http://togogenome.org/gene/1461582:RZ44_RS06820 ^@ http://purl.uniprot.org/uniprot/A0A078M888 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01770 ^@ http://purl.uniprot.org/uniprot/A0A078LYW5 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/1461582:RZ44_RS08720 ^@ http://purl.uniprot.org/uniprot/A0A078M5N0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06030 ^@ http://purl.uniprot.org/uniprot/A0A078M963 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. EmrB family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04155 ^@ http://purl.uniprot.org/uniprot/A0A078M208 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS10305 ^@ http://purl.uniprot.org/uniprot/A0A078M8C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06650 ^@ http://purl.uniprot.org/uniprot/A0A078M9Y3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/1461582:RZ44_RS11060 ^@ http://purl.uniprot.org/uniprot/A0A078M8I2 ^@ Similarity ^@ Belongs to the UPF0355 family. http://togogenome.org/gene/1461582:RZ44_RS06610 ^@ http://purl.uniprot.org/uniprot/A0A078M9W8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/1461582:RZ44_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A078LZX7 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/1461582:RZ44_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A078M122 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS04430 ^@ http://purl.uniprot.org/uniprot/A0A078M6P4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/1461582:RZ44_RS02320 ^@ http://purl.uniprot.org/uniprot/A0A078LW71 ^@ Function|||Similarity|||Subunit ^@ Associates with stalled 50S ribosomal subunits.|||Belongs to the NEMF family.|||Part of the ribosome quality control system (RQC). Recruits Ala-charged tRNA and directs the elongation of stalled nascent chains on 50S ribosomal subunits, leading to non-templated C-terminal Ala extensions (Ala tail). The Ala tail promotes nascent chain degradation. May add between 1 and at least 8 Ala residues. Binds to stalled 50S ribosomal subunits. http://togogenome.org/gene/1461582:RZ44_RS03665 ^@ http://purl.uniprot.org/uniprot/A0A078M5K6 ^@ Function|||Similarity ^@ Belongs to the pyruvate, phosphate/water dikinase regulatory protein family. PDRP subfamily.|||Bifunctional serine/threonine kinase and phosphorylase involved in the regulation of the pyruvate, phosphate dikinase (PPDK) by catalyzing its phosphorylation/dephosphorylation. http://togogenome.org/gene/1461582:RZ44_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A078M856 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/1461582:RZ44_RS06565 ^@ http://purl.uniprot.org/uniprot/A0A078M9U7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS02165 ^@ http://purl.uniprot.org/uniprot/A0A078LZL6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02600 ^@ http://purl.uniprot.org/uniprot/A0A078M006 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09865 ^@ http://purl.uniprot.org/uniprot/A0A078M7G0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/1461582:RZ44_RS02230 ^@ http://purl.uniprot.org/uniprot/A0A078M220 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/1461582:RZ44_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A078M0U5 ^@ Similarity ^@ Belongs to the UPF0297 family. http://togogenome.org/gene/1461582:RZ44_RS10695 ^@ http://purl.uniprot.org/uniprot/A0A078M8U8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/1461582:RZ44_RS11335 ^@ http://purl.uniprot.org/uniprot/A0A078M9Q1 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/1461582:RZ44_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A078M0Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS08890 ^@ http://purl.uniprot.org/uniprot/A0A078M9A6 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS08560 ^@ http://purl.uniprot.org/uniprot/A0A078M5H5 ^@ Similarity|||Subunit ^@ Belongs to the azoreductase type 2 family.|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A078LVH5 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subunit ^@ Activated by phosphorylation and inhibited by fructose 1,6-bisphosphate (FBP).|||Belongs to the FGGY kinase family.|||Homotetramer and homodimer (in equilibrium).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), including enzyme I, and histidine-containing protein (HPr) are required for the phosphorylation, which leads to the activation of the enzyme. http://togogenome.org/gene/1461582:RZ44_RS03635 ^@ http://purl.uniprot.org/uniprot/A0A078M3W3 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/1461582:RZ44_RS10855 ^@ http://purl.uniprot.org/uniprot/A0A078MEU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/1461582:RZ44_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A078LYD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07025 ^@ http://purl.uniprot.org/uniprot/A0A078M659 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS06505 ^@ http://purl.uniprot.org/uniprot/A0A078M9S2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS10560 ^@ http://purl.uniprot.org/uniprot/A0A078MGK5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS02290 ^@ http://purl.uniprot.org/uniprot/A0A078M3Z7 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/1461582:RZ44_RS10825 ^@ http://purl.uniprot.org/uniprot/A0A078MCL1 ^@ Similarity ^@ Belongs to the beta-class carbonic anhydrase family. http://togogenome.org/gene/1461582:RZ44_RS02615 ^@ http://purl.uniprot.org/uniprot/A0A078M013 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/1461582:RZ44_RS06685 ^@ http://purl.uniprot.org/uniprot/A0A078M5K7 ^@ Function|||Similarity ^@ Belongs to the IMPDH/GMPR family. GuaC type 2 subfamily.|||Catalyzes the irreversible NADPH-dependent deamination of GMP to IMP. It functions in the conversion of nucleobase, nucleoside and nucleotide derivatives of G to A nucleotides, and in maintaining the intracellular balance of A and G nucleotides. http://togogenome.org/gene/1461582:RZ44_RS08360 ^@ http://purl.uniprot.org/uniprot/A0A078MAT5 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/1461582:RZ44_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A078M622 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/1461582:RZ44_RS05240 ^@ http://purl.uniprot.org/uniprot/A0A078M841 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07255 ^@ http://purl.uniprot.org/uniprot/A0A078M6F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. Thioredoxin-coupled ArsC subfamily.|||Catalyzes the reduction of arsenate [As(V)] to arsenite [As(III)].|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS07250 ^@ http://purl.uniprot.org/uniprot/A0A078MB03 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20 family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/1461582:RZ44_RS09585 ^@ http://purl.uniprot.org/uniprot/A0A078MA84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EamA transporter family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A078M8V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09670 ^@ http://purl.uniprot.org/uniprot/A0A078M748 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A078M2G2 ^@ Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/1461582:RZ44_RS03715 ^@ http://purl.uniprot.org/uniprot/A0A078M3Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A078M8B1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS09095 ^@ http://purl.uniprot.org/uniprot/A0A078MBT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane|||Part of the binding-protein-dependent transport system for heme-iron. Responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/1461582:RZ44_RS08765 ^@ http://purl.uniprot.org/uniprot/A0A078M952 ^@ Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/1461582:RZ44_RS03550 ^@ http://purl.uniprot.org/uniprot/A0A078M3S7 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/1461582:RZ44_RS03325 ^@ http://purl.uniprot.org/uniprot/A0A078M0Y2 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/1461582:RZ44_RS06535 ^@ http://purl.uniprot.org/uniprot/A0A078M5C9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/1461582:RZ44_RS05375 ^@ http://purl.uniprot.org/uniprot/A0A078M882 ^@ Function|||Similarity ^@ Belongs to the histone deacetylase family.|||Role in growth on acetoin or butanediol. Involved in the breakdown of these compounds used as a carbon source. http://togogenome.org/gene/1461582:RZ44_RS02475 ^@ http://purl.uniprot.org/uniprot/A0A078LWD3 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/1461582:RZ44_RS06930 ^@ http://purl.uniprot.org/uniprot/A0A078MAK4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A078M0X3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS07970 ^@ http://purl.uniprot.org/uniprot/A0A078MA50 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/1461582:RZ44_RS08265 ^@ http://purl.uniprot.org/uniprot/A0A078M868 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS09740 ^@ http://purl.uniprot.org/uniprot/A0A078MAH0 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/1461582:RZ44_RS08730 ^@ http://purl.uniprot.org/uniprot/A0A078MBE7 ^@ Function|||Similarity ^@ Belongs to the CtsR family.|||Negative regulator of clpC, clpB and clpP transcription by binding directly and specifically to their promoter region. http://togogenome.org/gene/1461582:RZ44_RS08275 ^@ http://purl.uniprot.org/uniprot/A0A078M872 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/1461582:RZ44_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A078M119 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05720 ^@ http://purl.uniprot.org/uniprot/A0A078M0W9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/1461582:RZ44_RS06720 ^@ http://purl.uniprot.org/uniprot/A0A078M5F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Catalyzes the sodium-dependent uptake of extracellular L-proline.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02595 ^@ http://purl.uniprot.org/uniprot/A0A078LWI2 ^@ Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP). http://togogenome.org/gene/1461582:RZ44_RS09055 ^@ http://purl.uniprot.org/uniprot/A0A078MDU6 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/1461582:RZ44_RS08855 ^@ http://purl.uniprot.org/uniprot/A0A078M9A4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/1461582:RZ44_RS09890 ^@ http://purl.uniprot.org/uniprot/A0A078MAS0 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/1461582:RZ44_RS04300 ^@ http://purl.uniprot.org/uniprot/A0A078M6J6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01660 ^@ http://purl.uniprot.org/uniprot/A0A078M384 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.|||Cytoplasm|||Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. http://togogenome.org/gene/1461582:RZ44_RS00055 ^@ http://purl.uniprot.org/uniprot/A0A078LUM0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/1461582:RZ44_RS10215 ^@ http://purl.uniprot.org/uniprot/A0A078MFT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08385 ^@ http://purl.uniprot.org/uniprot/A0A078M8E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0291 family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS01970 ^@ http://purl.uniprot.org/uniprot/A0A078LZ45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01390 ^@ http://purl.uniprot.org/uniprot/A0A078M335 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/1461582:RZ44_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A078M1E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS01515 ^@ http://purl.uniprot.org/uniprot/A0A078M1E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS01545 ^@ http://purl.uniprot.org/uniprot/A0A078LVI1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArsC family. Spx subfamily.|||Cytoplasm|||Global transcriptional regulator that plays a key role in stress response and exerts either positive or negative regulation of genes. Acts by interacting with the C-terminal domain of the alpha subunit of the RNA polymerase (RNAP). This interaction can enhance binding of RNAP to the promoter region of target genes and stimulate their transcription, or block interaction of RNAP with activator.|||Interacts with the C-terminal domain of the alpha subunit of the RNAP. http://togogenome.org/gene/1461582:RZ44_RS06965 ^@ http://purl.uniprot.org/uniprot/A0A078M8I1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/1461582:RZ44_RS04985 ^@ http://purl.uniprot.org/uniprot/A0A078M354 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10755 ^@ http://purl.uniprot.org/uniprot/A0A078M8Y6 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01075 ^@ http://purl.uniprot.org/uniprot/A0A078LV76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/1461582:RZ44_RS08595 ^@ http://purl.uniprot.org/uniprot/A0A078MD83 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/1461582:RZ44_RS01850 ^@ http://purl.uniprot.org/uniprot/A0A078M3E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06530 ^@ http://purl.uniprot.org/uniprot/A0A078M9T4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/1461582:RZ44_RS00980 ^@ http://purl.uniprot.org/uniprot/A0A078LYH7 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS08915 ^@ http://purl.uniprot.org/uniprot/A0A078MDR5 ^@ Function|||Similarity ^@ Belongs to the GTP cyclohydrolase IV family.|||Converts GTP to 7,8-dihydroneopterin triphosphate. http://togogenome.org/gene/1461582:RZ44_RS10890 ^@ http://purl.uniprot.org/uniprot/A0A078MEW7 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS04695 ^@ http://purl.uniprot.org/uniprot/A0A078M2N2 ^@ Similarity ^@ Belongs to the CpsD/CapB family. http://togogenome.org/gene/1461582:RZ44_RS01955 ^@ http://purl.uniprot.org/uniprot/A0A078LVT7 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Lipoamide dehydrogenase is a component of the alpha-ketoacid dehydrogenase complexes.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/1461582:RZ44_RS00340 ^@ http://purl.uniprot.org/uniprot/A0A078LY93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 5 family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08000 ^@ http://purl.uniprot.org/uniprot/A0A078MA68 ^@ Caution|||Function|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in DNA replication, recombination and repair. Binds to ssDNA and to an array of partner proteins to recruit them to their sites of action during DNA metabolism. http://togogenome.org/gene/1461582:RZ44_RS01415 ^@ http://purl.uniprot.org/uniprot/A0A078M340 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/1461582:RZ44_RS01225 ^@ http://purl.uniprot.org/uniprot/A0A078LVA5 ^@ Function|||Similarity ^@ Belongs to the ROK (NagC/XylR) family.|||Transcriptional repressor of xylose-utilizing enzymes. http://togogenome.org/gene/1461582:RZ44_RS02765 ^@ http://purl.uniprot.org/uniprot/A0A078M067 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS01045 ^@ http://purl.uniprot.org/uniprot/A0A078M125 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/1461582:RZ44_RS00520 ^@ http://purl.uniprot.org/uniprot/A0A078LY96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HsdR family.|||Subunit R is required for both nuclease and ATPase activities, but not for modification.|||The type I restriction/modification system is composed of three polypeptides R, M and S. http://togogenome.org/gene/1461582:RZ44_RS00815 ^@ http://purl.uniprot.org/uniprot/A0A078LYG5 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/1461582:RZ44_RS02225 ^@ http://purl.uniprot.org/uniprot/A0A078LW27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cell division protein that is involved in the assembly of the Z ring. May serve as a membrane anchor for the Z ring.|||Cell membrane|||Self-interacts. Interacts with FtsZ. http://togogenome.org/gene/1461582:RZ44_RS08825 ^@ http://purl.uniprot.org/uniprot/A0A078MDM7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/1461582:RZ44_RS03675 ^@ http://purl.uniprot.org/uniprot/A0A078M1A6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/1461582:RZ44_RS08770 ^@ http://purl.uniprot.org/uniprot/A0A078MBH0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A078M115 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS04920 ^@ http://purl.uniprot.org/uniprot/A0A078LZW1 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/1461582:RZ44_RS09735 ^@ http://purl.uniprot.org/uniprot/A0A078MCZ8 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS02780 ^@ http://purl.uniprot.org/uniprot/A0A078M342 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS07635 ^@ http://purl.uniprot.org/uniprot/A0A078MBM8 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/1461582:RZ44_RS09780 ^@ http://purl.uniprot.org/uniprot/A0A078MD19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/1461582:RZ44_RS09405 ^@ http://purl.uniprot.org/uniprot/A0A078MCC8 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/1461582:RZ44_RS10625 ^@ http://purl.uniprot.org/uniprot/A0A078MCA1 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/1461582:RZ44_RS00210 ^@ http://purl.uniprot.org/uniprot/A0A078LUR1 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/1461582:RZ44_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A078M135 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/1461582:RZ44_RS00500 ^@ http://purl.uniprot.org/uniprot/A0A078M2B5 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/1461582:RZ44_RS09460 ^@ http://purl.uniprot.org/uniprot/A0A078M6Q2 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05905 ^@ http://purl.uniprot.org/uniprot/A0A078M184 ^@ Similarity ^@ Belongs to the UPF0342 family. http://togogenome.org/gene/1461582:RZ44_RS06420 ^@ http://purl.uniprot.org/uniprot/A0A078M4V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05200 ^@ http://purl.uniprot.org/uniprot/A0A078M3I8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS04895 ^@ http://purl.uniprot.org/uniprot/A0A078LZT1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/1461582:RZ44_RS02655 ^@ http://purl.uniprot.org/uniprot/A0A078M2M1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/1461582:RZ44_RS09695 ^@ http://purl.uniprot.org/uniprot/A0A078M755 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/1461582:RZ44_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A078M266 ^@ Similarity ^@ Belongs to the NtaA/SnaA/DszA monooxygenase family. http://togogenome.org/gene/1461582:RZ44_RS09980 ^@ http://purl.uniprot.org/uniprot/A0A078MFF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/1461582:RZ44_RS03785 ^@ http://purl.uniprot.org/uniprot/A0A078LY20 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS01085 ^@ http://purl.uniprot.org/uniprot/A0A078LYM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A078LYW9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/1461582:RZ44_RS07050 ^@ http://purl.uniprot.org/uniprot/A0A078M2U3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS10245 ^@ http://purl.uniprot.org/uniprot/A0A078MBJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS00325 ^@ http://purl.uniprot.org/uniprot/A0A078M288 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09965 ^@ http://purl.uniprot.org/uniprot/A0A078M7L2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/1461582:RZ44_RS02495 ^@ http://purl.uniprot.org/uniprot/A0A078M4A0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/1461582:RZ44_RS07145 ^@ http://purl.uniprot.org/uniprot/A0A078M6B1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS02215 ^@ http://purl.uniprot.org/uniprot/A0A078LZF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS09830 ^@ http://purl.uniprot.org/uniprot/A0A078M7D6 ^@ Function|||Similarity ^@ Belongs to the Thz kinase family.|||Catalyzes the phosphorylation of the hydroxyl group of 4-methyl-5-beta-hydroxyethylthiazole (THZ). http://togogenome.org/gene/1461582:RZ44_RS08835 ^@ http://purl.uniprot.org/uniprot/A0A078M981 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/1461582:RZ44_RS02030 ^@ http://purl.uniprot.org/uniprot/A0A078LVW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/1461582:RZ44_RS03935 ^@ http://purl.uniprot.org/uniprot/A0A078M1L3 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/1461582:RZ44_RS01695 ^@ http://purl.uniprot.org/uniprot/A0A078LVL1 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. Sigma-S contributes to the protection against external stress, thus playing a role in cellular fitness and survival. http://togogenome.org/gene/1461582:RZ44_RS03285 ^@ http://purl.uniprot.org/uniprot/A0A078LXB9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/1461582:RZ44_RS09525 ^@ http://purl.uniprot.org/uniprot/A0A078MEP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0053 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10470 ^@ http://purl.uniprot.org/uniprot/A0A078M8K5 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/1461582:RZ44_RS05380 ^@ http://purl.uniprot.org/uniprot/A0A078M0H2 ^@ Function ^@ Global transcriptional regulator of carbon catabolite repression (CCR) and carbon catabolite activation (CCA), which ensures optimal energy usage under diverse conditions. http://togogenome.org/gene/1461582:RZ44_RS03905 ^@ http://purl.uniprot.org/uniprot/A0A078M5V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/1461582:RZ44_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A078LYN3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/1461582:RZ44_RS10225 ^@ http://purl.uniprot.org/uniprot/A0A078MDP9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/1461582:RZ44_RS00330 ^@ http://purl.uniprot.org/uniprot/A0A078M0L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06945 ^@ http://purl.uniprot.org/uniprot/A0A078M624 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS10830 ^@ http://purl.uniprot.org/uniprot/A0A078MES4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02330 ^@ http://purl.uniprot.org/uniprot/A0A078M262 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1461582:RZ44_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A078LXN1 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/1461582:RZ44_RS07350 ^@ http://purl.uniprot.org/uniprot/A0A078M910 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/1461582:RZ44_RS11000 ^@ http://purl.uniprot.org/uniprot/A0A078M7T3 ^@ Similarity ^@ Belongs to the TRAP family. http://togogenome.org/gene/1461582:RZ44_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A078LY14 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. ClpC subfamily. http://togogenome.org/gene/1461582:RZ44_RS02945 ^@ http://purl.uniprot.org/uniprot/A0A078M0J3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/1461582:RZ44_RS03160 ^@ http://purl.uniprot.org/uniprot/A0A078M0S4 ^@ Similarity|||Subunit ^@ Belongs to the SMC family. SbcC subfamily.|||Heterodimer of SbcC and SbcD. http://togogenome.org/gene/1461582:RZ44_RS01480 ^@ http://purl.uniprot.org/uniprot/A0A078LYY2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09845 ^@ http://purl.uniprot.org/uniprot/A0A078M7E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08830 ^@ http://purl.uniprot.org/uniprot/A0A078M5S7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/1461582:RZ44_RS01005 ^@ http://purl.uniprot.org/uniprot/A0A078LYK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/1461582:RZ44_RS03895 ^@ http://purl.uniprot.org/uniprot/A0A078M1D4 ^@ Function|||Similarity ^@ Belongs to the asp23 family.|||May play a key role in alkaline pH tolerance. http://togogenome.org/gene/1461582:RZ44_RS06950 ^@ http://purl.uniprot.org/uniprot/A0A078M8H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A078M3K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A078M2M9 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/1461582:RZ44_RS10145 ^@ http://purl.uniprot.org/uniprot/A0A078MB57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS09085 ^@ http://purl.uniprot.org/uniprot/A0A078M628 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A078M4A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Fur family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS05145 ^@ http://purl.uniprot.org/uniprot/A0A078M3F5 ^@ Function|||Similarity ^@ Belongs to the AlaDH/PNT family.|||May play a role in cell wall synthesis as L-alanine is an important constituent of the peptidoglycan layer. http://togogenome.org/gene/1461582:RZ44_RS02790 ^@ http://purl.uniprot.org/uniprot/A0A078M4R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07445 ^@ http://purl.uniprot.org/uniprot/A0A078M6T2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS06405 ^@ http://purl.uniprot.org/uniprot/A0A078M9M6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS08235 ^@ http://purl.uniprot.org/uniprot/A0A078MAJ6 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/1461582:RZ44_RS08125 ^@ http://purl.uniprot.org/uniprot/A0A078MAE4 ^@ Function ^@ May be involved in multidrug export. Transmembrane domains (TMD) form a pore in the cell membrane and the ATP-binding domain (NBD) is responsible for energy generation. http://togogenome.org/gene/1461582:RZ44_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A078M2Q3 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/1461582:RZ44_RS10230 ^@ http://purl.uniprot.org/uniprot/A0A078MBA8 ^@ Cofactor|||Similarity ^@ Belongs to the nitroreductase family.|||Binds 1 FMN per subunit. http://togogenome.org/gene/1461582:RZ44_RS01940 ^@ http://purl.uniprot.org/uniprot/A0A078M1P2 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta chain.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/1461582:RZ44_RS01295 ^@ http://purl.uniprot.org/uniprot/A0A078M1A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/1461582:RZ44_RS07795 ^@ http://purl.uniprot.org/uniprot/A0A078M3V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/1461582:RZ44_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A078LYX1 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/1461582:RZ44_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A078M3N7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS06400 ^@ http://purl.uniprot.org/uniprot/A0A078M561 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/1461582:RZ44_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A078M6F6 ^@ Function|||Similarity ^@ 3'-5' exonuclease.|||Belongs to the helicase family. DinG subfamily. Type 2 sub-subfamily. http://togogenome.org/gene/1461582:RZ44_RS05045 ^@ http://purl.uniprot.org/uniprot/A0A078M385 ^@ Function|||Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Catalyzes the oxidative phosphorylation of glyceraldehyde 3-phosphate (G3P) to 1,3-bisphosphoglycerate (BPG) using the cofactor NAD. The first reaction step involves the formation of a hemiacetal intermediate between G3P and a cysteine residue, and this hemiacetal intermediate is then oxidized to a thioester, with concomitant reduction of NAD to NADH. The reduced NADH is then exchanged with the second NAD, and the thioester is attacked by a nucleophilic inorganic phosphate to produce BPG. http://togogenome.org/gene/1461582:RZ44_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A078MA52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A078M3Z4 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS00265 ^@ http://purl.uniprot.org/uniprot/A0A078LY83 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/1461582:RZ44_RS05030 ^@ http://purl.uniprot.org/uniprot/A0A078M5T0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/1461582:RZ44_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A078LYY8 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/1461582:RZ44_RS02540 ^@ http://purl.uniprot.org/uniprot/A0A078M4B3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/1461582:RZ44_RS06425 ^@ http://purl.uniprot.org/uniprot/A0A078M1V3 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/1461582:RZ44_RS05420 ^@ http://purl.uniprot.org/uniprot/A0A078M3S3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/1461582:RZ44_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A078LYL8 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/1461582:RZ44_RS09950 ^@ http://purl.uniprot.org/uniprot/A0A078MB30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS08610 ^@ http://purl.uniprot.org/uniprot/A0A078M8W6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P).|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS02505 ^@ http://purl.uniprot.org/uniprot/A0A078LZW9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/1461582:RZ44_RS07185 ^@ http://purl.uniprot.org/uniprot/A0A078MAW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A078M4I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Binds mRNA; thus facilitating recognition of the initiation point. It is needed to translate mRNA with a short Shine-Dalgarno (SD) purine-rich sequence.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/1461582:RZ44_RS07535 ^@ http://purl.uniprot.org/uniprot/A0A078M6W3 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/1461582:RZ44_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A078M2I7 ^@ Similarity ^@ Belongs to the ThrE exporter (TC 2.A.79) family. http://togogenome.org/gene/1461582:RZ44_RS09775 ^@ http://purl.uniprot.org/uniprot/A0A078MAT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/1461582:RZ44_RS09110 ^@ http://purl.uniprot.org/uniprot/A0A078M638 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. http://togogenome.org/gene/1461582:RZ44_RS02105 ^@ http://purl.uniprot.org/uniprot/A0A078M1V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A078MCQ9 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/1461582:RZ44_RS00095 ^@ http://purl.uniprot.org/uniprot/A0A078M250 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvP family. C-terminal subunit subfamily.|||The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. In this organism, the P 'protein' is a heterodimer of two subunits. http://togogenome.org/gene/1461582:RZ44_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A078M7H7 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/1461582:RZ44_RS08785 ^@ http://purl.uniprot.org/uniprot/A0A078MBH7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/1461582:RZ44_RS07345 ^@ http://purl.uniprot.org/uniprot/A0A078M6L1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin.|||Forms an icosahedral capsid composed of 60 subunits, arranged as a dodecamer of pentamers. http://togogenome.org/gene/1461582:RZ44_RS01425 ^@ http://purl.uniprot.org/uniprot/A0A078LVG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Cell membrane|||Essential for cell viability.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS02340 ^@ http://purl.uniprot.org/uniprot/A0A078M424 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/1461582:RZ44_RS10580 ^@ http://purl.uniprot.org/uniprot/A0A078M8Q3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPase class C family.|||Binds 2 manganese ions per subunit.|||Cytoplasm http://togogenome.org/gene/1461582:RZ44_RS01275 ^@ http://purl.uniprot.org/uniprot/A0A078LVE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/1461582:RZ44_RS01535 ^@ http://purl.uniprot.org/uniprot/A0A078M361 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/1461582:RZ44_RS02575 ^@ http://purl.uniprot.org/uniprot/A0A078M4C9 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/1461582:RZ44_RS07665 ^@ http://purl.uniprot.org/uniprot/A0A078M9N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/1461582:RZ44_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A078M652 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/1461582:RZ44_RS02490 ^@ http://purl.uniprot.org/uniprot/A0A078LZT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/1461582:RZ44_RS07990 ^@ http://purl.uniprot.org/uniprot/A0A078MC71 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/1461582:RZ44_RS09060 ^@ http://purl.uniprot.org/uniprot/A0A078M619 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the octanoyltransferase LipL family.|||Catalyzes the amidotransfer (transamidation) of the octanoyl moiety from octanoyl-GcvH to the lipoyl domain of the E2 subunit of lipoate-dependent enzymes.|||The reaction proceeds via a thioester-linked acyl-enzyme intermediate. http://togogenome.org/gene/1461582:RZ44_RS06700 ^@ http://purl.uniprot.org/uniprot/A0A078M5L6 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/1461582:RZ44_RS03600 ^@ http://purl.uniprot.org/uniprot/A0A078LXP7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/1461582:RZ44_RS10440 ^@ http://purl.uniprot.org/uniprot/A0A078MBR4 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Purine salvage pathway enzyme that catalyzes the transfer of the ribosyl-5-phosphate group from 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to the N9 position of the 6-oxopurines hypoxanthine and guanine to form the corresponding ribonucleotides IMP (inosine 5'-monophosphate) and GMP (guanosine 5'-monophosphate), with the release of PPi. http://togogenome.org/gene/1461582:RZ44_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A078LW83 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/1461582:RZ44_RS07460 ^@ http://purl.uniprot.org/uniprot/A0A078M6S6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/1461582:RZ44_RS01890 ^@ http://purl.uniprot.org/uniprot/A0A078M1M5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS10015 ^@ http://purl.uniprot.org/uniprot/A0A078MFH2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/1461582:RZ44_RS03585 ^@ http://purl.uniprot.org/uniprot/A0A078M3U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/1461582:RZ44_RS06855 ^@ http://purl.uniprot.org/uniprot/A0A078M8A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/1461582:RZ44_RS08850 ^@ http://purl.uniprot.org/uniprot/A0A078MBK5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/1461582:RZ44_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A078M6H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/1461582:RZ44_RS07885 ^@ http://purl.uniprot.org/uniprot/A0A078M7G8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/1461582:RZ44_RS06010 ^@ http://purl.uniprot.org/uniprot/A0A078M766 ^@ Similarity ^@ Belongs to the UPF0312 family. http://togogenome.org/gene/1461582:RZ44_RS04690 ^@ http://purl.uniprot.org/uniprot/A0A078M577 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/1461582:RZ44_RS02380 ^@ http://purl.uniprot.org/uniprot/A0A078M285 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/1461582:RZ44_RS08020 ^@ http://purl.uniprot.org/uniprot/A0A078M7U7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6.