http://togogenome.org/gene/158189:SPIBUDDY_RS03875 ^@ http://purl.uniprot.org/uniprot/F0RYA1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS07100 ^@ http://purl.uniprot.org/uniprot/F0RZ10 ^@ Similarity ^@ Belongs to the RibF family. http://togogenome.org/gene/158189:SPIBUDDY_RS07075 ^@ http://purl.uniprot.org/uniprot/F0RZ05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09610 ^@ http://purl.uniprot.org/uniprot/F0RWT3 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/158189:SPIBUDDY_RS15115 ^@ http://purl.uniprot.org/uniprot/F0RZP1 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS08065 ^@ http://purl.uniprot.org/uniprot/F0RZC7 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/158189:SPIBUDDY_RS08485 ^@ http://purl.uniprot.org/uniprot/F0RZE2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/158189:SPIBUDDY_RS11625 ^@ http://purl.uniprot.org/uniprot/F0RSJ4 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/158189:SPIBUDDY_RS13815 ^@ http://purl.uniprot.org/uniprot/F0RRT8 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS00975 ^@ http://purl.uniprot.org/uniprot/F0RXI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07115 ^@ http://purl.uniprot.org/uniprot/F0RZ13 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/158189:SPIBUDDY_RS11645 ^@ http://purl.uniprot.org/uniprot/F0RSJ8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the adenylate cyclase family. DacA/CdaA subfamily.|||Catalyzes the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP), a second messenger used to regulate differing processes in different bacteria.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probably a homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS00890 ^@ http://purl.uniprot.org/uniprot/F0RXG9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06420 ^@ http://purl.uniprot.org/uniprot/F0RYV1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/158189:SPIBUDDY_RS09885 ^@ http://purl.uniprot.org/uniprot/F0RWY5 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10885 ^@ http://purl.uniprot.org/uniprot/F0RT14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06480 ^@ http://purl.uniprot.org/uniprot/F0RYW3 ^@ Function|||Similarity ^@ Belongs to the GTP-binding SRP family.|||Necessary for flagellar biosynthesis. May be involved in translocation of the flagellum. http://togogenome.org/gene/158189:SPIBUDDY_RS07205 ^@ http://purl.uniprot.org/uniprot/F0RZ31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09185 ^@ http://purl.uniprot.org/uniprot/F0RWJ9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05190 ^@ http://purl.uniprot.org/uniprot/F0RYL3 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/158189:SPIBUDDY_RS06135 ^@ http://purl.uniprot.org/uniprot/F0RVP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07150 ^@ http://purl.uniprot.org/uniprot/F0RZ20 ^@ Caution|||Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/158189:SPIBUDDY_RS08285 ^@ http://purl.uniprot.org/uniprot/F0RW96 ^@ Similarity ^@ Belongs to the KdgT transporter family. http://togogenome.org/gene/158189:SPIBUDDY_RS00340 ^@ http://purl.uniprot.org/uniprot/F0RX63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. Galactose/methyl galactoside importer (TC 3.A.1.2.3) family.|||Cell inner membrane|||Part of the ABC transporter complex MglABC involved in galactose/methyl galactoside import. Responsible for energy coupling to the transport system.|||The complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB). http://togogenome.org/gene/158189:SPIBUDDY_RS11175 ^@ http://purl.uniprot.org/uniprot/F0RSW6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. RimO subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of an aspartic acid residue of ribosomal protein S12.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS13805 ^@ http://purl.uniprot.org/uniprot/F0RRT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04830 ^@ http://purl.uniprot.org/uniprot/F0RV64 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS10660 ^@ http://purl.uniprot.org/uniprot/F0RTL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/158189:SPIBUDDY_RS04405 ^@ http://purl.uniprot.org/uniprot/F0RYD1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS06095 ^@ http://purl.uniprot.org/uniprot/F0RVN7 ^@ Similarity ^@ Belongs to the FemABX family. http://togogenome.org/gene/158189:SPIBUDDY_RS05015 ^@ http://purl.uniprot.org/uniprot/F0RVA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13650 ^@ http://purl.uniprot.org/uniprot/F0RRS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08630 ^@ http://purl.uniprot.org/uniprot/F0RZH1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11755 ^@ http://purl.uniprot.org/uniprot/F0RSN2 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/158189:SPIBUDDY_RS13655 ^@ http://purl.uniprot.org/uniprot/F0RRS5 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09840 ^@ http://purl.uniprot.org/uniprot/F0RWX7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/158189:SPIBUDDY_RS00415 ^@ http://purl.uniprot.org/uniprot/F0RX78 ^@ Cofactor|||Similarity ^@ Belongs to the rubredoxin family.|||Binds 1 Fe(3+) ion per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS11635 ^@ http://purl.uniprot.org/uniprot/F0RSJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/158189:SPIBUDDY_RS07840 ^@ http://purl.uniprot.org/uniprot/F0RZ82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09135 ^@ http://purl.uniprot.org/uniprot/F0RWI9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/158189:SPIBUDDY_RS02005 ^@ http://purl.uniprot.org/uniprot/F0RXV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14160 ^@ http://purl.uniprot.org/uniprot/F0RS06 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/158189:SPIBUDDY_RS05790 ^@ http://purl.uniprot.org/uniprot/F0RVH9 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS02210 ^@ http://purl.uniprot.org/uniprot/F0RUB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00025 ^@ http://purl.uniprot.org/uniprot/F0RX01 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/158189:SPIBUDDY_RS09120 ^@ http://purl.uniprot.org/uniprot/F0RWI6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14445 ^@ http://purl.uniprot.org/uniprot/F0RS65 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/158189:SPIBUDDY_RS07695 ^@ http://purl.uniprot.org/uniprot/F0RW48 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/158189:SPIBUDDY_RS15790 ^@ http://purl.uniprot.org/uniprot/F0RSW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/158189:SPIBUDDY_RS07020 ^@ http://purl.uniprot.org/uniprot/F0RYZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS14415 ^@ http://purl.uniprot.org/uniprot/F0RS59 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/158189:SPIBUDDY_RS13635 ^@ http://purl.uniprot.org/uniprot/F0RSP8 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS06620 ^@ http://purl.uniprot.org/uniprot/F0RVR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/158189:SPIBUDDY_RS07225 ^@ http://purl.uniprot.org/uniprot/F0RZ35 ^@ Function ^@ Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine. http://togogenome.org/gene/158189:SPIBUDDY_RS11110 ^@ http://purl.uniprot.org/uniprot/F0RSV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00345 ^@ http://purl.uniprot.org/uniprot/F0RX64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09795 ^@ http://purl.uniprot.org/uniprot/F0RWW8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10825 ^@ http://purl.uniprot.org/uniprot/F0RT04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08705 ^@ http://purl.uniprot.org/uniprot/F0RZI5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/158189:SPIBUDDY_RS04190 ^@ http://purl.uniprot.org/uniprot/F0RV11 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS09160 ^@ http://purl.uniprot.org/uniprot/F0RWJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS14710 ^@ http://purl.uniprot.org/uniprot/F0RTQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/158189:SPIBUDDY_RS14665 ^@ http://purl.uniprot.org/uniprot/F0RS99 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/158189:SPIBUDDY_RS05980 ^@ http://purl.uniprot.org/uniprot/F0RVL4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/158189:SPIBUDDY_RS06210 ^@ http://purl.uniprot.org/uniprot/F0RYR6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/158189:SPIBUDDY_RS05470 ^@ http://purl.uniprot.org/uniprot/F0RVC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0324 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04940 ^@ http://purl.uniprot.org/uniprot/F0RV86 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02595 ^@ http://purl.uniprot.org/uniprot/F0RUJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11050 ^@ http://purl.uniprot.org/uniprot/F0RSU3 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08520 ^@ http://purl.uniprot.org/uniprot/F0RZE9 ^@ Similarity ^@ Belongs to the FemABX family. http://togogenome.org/gene/158189:SPIBUDDY_RS08815 ^@ http://purl.uniprot.org/uniprot/F0RWC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/158189:SPIBUDDY_RS07165 ^@ http://purl.uniprot.org/uniprot/F0RZ23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/158189:SPIBUDDY_RS11620 ^@ http://purl.uniprot.org/uniprot/F0RSJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/158189:SPIBUDDY_RS04575 ^@ http://purl.uniprot.org/uniprot/F0RYG4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS07105 ^@ http://purl.uniprot.org/uniprot/F0RZ11 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/158189:SPIBUDDY_RS13595 ^@ http://purl.uniprot.org/uniprot/F0RSP0 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00430 ^@ http://purl.uniprot.org/uniprot/F0RX81 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/158189:SPIBUDDY_RS10290 ^@ http://purl.uniprot.org/uniprot/F0RTT2 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/158189:SPIBUDDY_RS09115 ^@ http://purl.uniprot.org/uniprot/F0RWI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11420 ^@ http://purl.uniprot.org/uniprot/F0RTY9 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS00365 ^@ http://purl.uniprot.org/uniprot/F0RX68 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13935 ^@ http://purl.uniprot.org/uniprot/F0RRW2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05945 ^@ http://purl.uniprot.org/uniprot/F0RVK7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS01790 ^@ http://purl.uniprot.org/uniprot/F0RXR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04410 ^@ http://purl.uniprot.org/uniprot/F0RYD2 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS12845 ^@ http://purl.uniprot.org/uniprot/F0RSF3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/158189:SPIBUDDY_RS10220 ^@ http://purl.uniprot.org/uniprot/F0RTW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11135 ^@ http://purl.uniprot.org/uniprot/F0RSX4 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/158189:SPIBUDDY_RS08530 ^@ http://purl.uniprot.org/uniprot/F0RZF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/158189:SPIBUDDY_RS07735 ^@ http://purl.uniprot.org/uniprot/F0RZ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02050 ^@ http://purl.uniprot.org/uniprot/F0RXW8 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/158189:SPIBUDDY_RS04600 ^@ http://purl.uniprot.org/uniprot/F0RYG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09100 ^@ http://purl.uniprot.org/uniprot/F0RWI2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS02340 ^@ http://purl.uniprot.org/uniprot/F0RUE0 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/158189:SPIBUDDY_RS10850 ^@ http://purl.uniprot.org/uniprot/F0RT09 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS15485 ^@ http://purl.uniprot.org/uniprot/F0RZV8 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/158189:SPIBUDDY_RS03235 ^@ http://purl.uniprot.org/uniprot/F0RUP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06265 ^@ http://purl.uniprot.org/uniprot/F0RYS7 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS12205 ^@ http://purl.uniprot.org/uniprot/F0RRH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12950 ^@ http://purl.uniprot.org/uniprot/F0RT69 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05670 ^@ http://purl.uniprot.org/uniprot/F0RVF6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. LL-diaminopimelate aminotransferase subfamily.|||Homodimer.|||Involved in the synthesis of meso-diaminopimelate (m-DAP or DL-DAP), required for both lysine and peptidoglycan biosynthesis. Catalyzes the direct conversion of tetrahydrodipicolinate to LL-diaminopimelate. http://togogenome.org/gene/158189:SPIBUDDY_RS07390 ^@ http://purl.uniprot.org/uniprot/F0RVY9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS06275 ^@ http://purl.uniprot.org/uniprot/F0RYS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS00385 ^@ http://purl.uniprot.org/uniprot/F0RX72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08985 ^@ http://purl.uniprot.org/uniprot/F0RWF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05880 ^@ http://purl.uniprot.org/uniprot/F0RVJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06690 ^@ http://purl.uniprot.org/uniprot/F0RVS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS13745 ^@ http://purl.uniprot.org/uniprot/F0RSC1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS02970 ^@ http://purl.uniprot.org/uniprot/F0RY03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03330 ^@ http://purl.uniprot.org/uniprot/F0RUR4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/158189:SPIBUDDY_RS09025 ^@ http://purl.uniprot.org/uniprot/F0RWG6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/158189:SPIBUDDY_RS14240 ^@ http://purl.uniprot.org/uniprot/F0RS22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/158189:SPIBUDDY_RS12920 ^@ http://purl.uniprot.org/uniprot/F0RTC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04310 ^@ http://purl.uniprot.org/uniprot/F0RV35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14355 ^@ http://purl.uniprot.org/uniprot/F0RS47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/158189:SPIBUDDY_RS05910 ^@ http://purl.uniprot.org/uniprot/F0RVK0 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/158189:SPIBUDDY_RS08760 ^@ http://purl.uniprot.org/uniprot/F0RZJ5 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/158189:SPIBUDDY_RS05400 ^@ http://purl.uniprot.org/uniprot/F0RYQ6 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09620 ^@ http://purl.uniprot.org/uniprot/F0RWT5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10180 ^@ http://purl.uniprot.org/uniprot/F0RTV4 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS05805 ^@ http://purl.uniprot.org/uniprot/F0RVI2 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS11345 ^@ http://purl.uniprot.org/uniprot/F0RTX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01710 ^@ http://purl.uniprot.org/uniprot/F0RU93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15310 ^@ http://purl.uniprot.org/uniprot/F0RZS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11675 ^@ http://purl.uniprot.org/uniprot/F0RSK5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS15175 ^@ http://purl.uniprot.org/uniprot/F0RZQ2 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS11790 ^@ http://purl.uniprot.org/uniprot/F0RSM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS01090 ^@ http://purl.uniprot.org/uniprot/F0RXK9 ^@ Similarity ^@ Belongs to the sulfur carrier protein TusA family. http://togogenome.org/gene/158189:SPIBUDDY_RS14660 ^@ http://purl.uniprot.org/uniprot/F0RS98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/158189:SPIBUDDY_RS08955 ^@ http://purl.uniprot.org/uniprot/F0RWF2 ^@ Similarity ^@ Belongs to the UPF0178 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06725 ^@ http://purl.uniprot.org/uniprot/F0RVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10600 ^@ http://purl.uniprot.org/uniprot/F0RTJ9 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/158189:SPIBUDDY_RS05105 ^@ http://purl.uniprot.org/uniprot/F0RYJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00905 ^@ http://purl.uniprot.org/uniprot/F0RXH2 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/158189:SPIBUDDY_RS04445 ^@ http://purl.uniprot.org/uniprot/F0RYD9 ^@ Similarity ^@ Belongs to the CobT family. http://togogenome.org/gene/158189:SPIBUDDY_RS07110 ^@ http://purl.uniprot.org/uniprot/F0RZ12 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS07050 ^@ http://purl.uniprot.org/uniprot/F0RZ00 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS12715 ^@ http://purl.uniprot.org/uniprot/F0RSC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01815 ^@ http://purl.uniprot.org/uniprot/F0RXS3 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02215 ^@ http://purl.uniprot.org/uniprot/F0RUB6 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/158189:SPIBUDDY_RS08920 ^@ http://purl.uniprot.org/uniprot/F0RWE5 ^@ Function|||Similarity ^@ Belongs to the class-I DAHP synthase family.|||Stereospecific condensation of phosphoenolpyruvate (PEP) and D-erythrose-4-phosphate (E4P) giving rise to 3-deoxy-D-arabino-heptulosonate-7-phosphate (DAHP). http://togogenome.org/gene/158189:SPIBUDDY_RS13785 ^@ http://purl.uniprot.org/uniprot/F0RRT2 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS11030 ^@ http://purl.uniprot.org/uniprot/F0RST9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00630 ^@ http://purl.uniprot.org/uniprot/F0RXB9 ^@ Similarity ^@ Belongs to the asparagine synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS07095 ^@ http://purl.uniprot.org/uniprot/F0RZ09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS05810 ^@ http://purl.uniprot.org/uniprot/F0RVI3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/158189:SPIBUDDY_RS13715 ^@ http://purl.uniprot.org/uniprot/F0RSB4 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/158189:SPIBUDDY_RS12530 ^@ http://purl.uniprot.org/uniprot/F0RRN2 ^@ Function ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/158189:SPIBUDDY_RS07665 ^@ http://purl.uniprot.org/uniprot/F0RW42 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02835 ^@ http://purl.uniprot.org/uniprot/F0RUN9 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS08785 ^@ http://purl.uniprot.org/uniprot/F0RZJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/158189:SPIBUDDY_RS00335 ^@ http://purl.uniprot.org/uniprot/F0RX62 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 2 family.|||Periplasm|||The ABC transporter complex is composed of one ATP-binding protein (MglA), two transmembrane proteins (MglC) and a solute-binding protein (MglB). http://togogenome.org/gene/158189:SPIBUDDY_RS09445 ^@ http://purl.uniprot.org/uniprot/F0RWQ0 ^@ Subcellular Location Annotation ^@ Virion http://togogenome.org/gene/158189:SPIBUDDY_RS12730 ^@ http://purl.uniprot.org/uniprot/F0RSD1 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/158189:SPIBUDDY_RS06455 ^@ http://purl.uniprot.org/uniprot/F0RYV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08245 ^@ http://purl.uniprot.org/uniprot/F0RW88 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/158189:SPIBUDDY_RS10970 ^@ http://purl.uniprot.org/uniprot/F0RSS8 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/158189:SPIBUDDY_RS03995 ^@ http://purl.uniprot.org/uniprot/F0RUX2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09995 ^@ http://purl.uniprot.org/uniprot/F0RZX7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01835 ^@ http://purl.uniprot.org/uniprot/F0RXS7 ^@ Function|||Similarity ^@ Acts on leucine, isoleucine and valine.|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS08350 ^@ http://purl.uniprot.org/uniprot/F0RWA9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14790 ^@ http://purl.uniprot.org/uniprot/F0RTN0 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/158189:SPIBUDDY_RS13605 ^@ http://purl.uniprot.org/uniprot/F0RSP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01795 ^@ http://purl.uniprot.org/uniprot/F0RXR9 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/158189:SPIBUDDY_RS02350 ^@ http://purl.uniprot.org/uniprot/F0RUE2 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/158189:SPIBUDDY_RS13995 ^@ http://purl.uniprot.org/uniprot/F0RRX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/158189:SPIBUDDY_RS14680 ^@ http://purl.uniprot.org/uniprot/F0RSA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05555 ^@ http://purl.uniprot.org/uniprot/F0RVD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the P(II) protein family.|||Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09060 ^@ http://purl.uniprot.org/uniprot/F0RWH3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS10215 ^@ http://purl.uniprot.org/uniprot/F0RTW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04730 ^@ http://purl.uniprot.org/uniprot/F0RV43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04795 ^@ http://purl.uniprot.org/uniprot/F0RV57 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14525 ^@ http://purl.uniprot.org/uniprot/F0RS80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10340 ^@ http://purl.uniprot.org/uniprot/F0RTU0 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS00010 ^@ http://purl.uniprot.org/uniprot/F0RWZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/158189:SPIBUDDY_RS07465 ^@ http://purl.uniprot.org/uniprot/F0RW04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14440 ^@ http://purl.uniprot.org/uniprot/F0RS64 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/158189:SPIBUDDY_RS01740 ^@ http://purl.uniprot.org/uniprot/F0RXQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07255 ^@ http://purl.uniprot.org/uniprot/F0RZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03845 ^@ http://purl.uniprot.org/uniprot/F0RY95 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||Involved in the biosynthesis of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP), two major building blocks of isoprenoid compounds. Catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10470 ^@ http://purl.uniprot.org/uniprot/F0RZY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00805 ^@ http://purl.uniprot.org/uniprot/F0RXF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01605 ^@ http://purl.uniprot.org/uniprot/F0RU73 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS00445 ^@ http://purl.uniprot.org/uniprot/F0RX84 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06115 ^@ http://purl.uniprot.org/uniprot/F0RVP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/158189:SPIBUDDY_RS14425 ^@ http://purl.uniprot.org/uniprot/F0RS61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/158189:SPIBUDDY_RS02000 ^@ http://purl.uniprot.org/uniprot/F0RXV8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08935 ^@ http://purl.uniprot.org/uniprot/F0RWE8 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/158189:SPIBUDDY_RS15340 ^@ http://purl.uniprot.org/uniprot/F0RZT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/158189:SPIBUDDY_RS14265 ^@ http://purl.uniprot.org/uniprot/F0RS27 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/158189:SPIBUDDY_RS00320 ^@ http://purl.uniprot.org/uniprot/F0RX59 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02900 ^@ http://purl.uniprot.org/uniprot/F0RXZ0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'B2' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/158189:SPIBUDDY_RS03360 ^@ http://purl.uniprot.org/uniprot/F0RUS0 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/158189:SPIBUDDY_RS03490 ^@ http://purl.uniprot.org/uniprot/F0RUU5 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/158189:SPIBUDDY_RS03860 ^@ http://purl.uniprot.org/uniprot/F0RY98 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/158189:SPIBUDDY_RS14850 ^@ http://purl.uniprot.org/uniprot/F0RTP2 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06405 ^@ http://purl.uniprot.org/uniprot/F0RYU8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/158189:SPIBUDDY_RS02745 ^@ http://purl.uniprot.org/uniprot/F0RUM2 ^@ Similarity ^@ Belongs to the xanthine dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04200 ^@ http://purl.uniprot.org/uniprot/F0RV13 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05915 ^@ http://purl.uniprot.org/uniprot/F0RVK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS02775 ^@ http://purl.uniprot.org/uniprot/F0RUM8 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14805 ^@ http://purl.uniprot.org/uniprot/F0RTN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-ACP thioesterase family.|||chloroplast http://togogenome.org/gene/158189:SPIBUDDY_RS06105 ^@ http://purl.uniprot.org/uniprot/F0RVN9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/158189:SPIBUDDY_RS08740 ^@ http://purl.uniprot.org/uniprot/F0RZJ1 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS05550 ^@ http://purl.uniprot.org/uniprot/F0RVD1 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08615 ^@ http://purl.uniprot.org/uniprot/F0RZG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07825 ^@ http://purl.uniprot.org/uniprot/F0RZ79 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/158189:SPIBUDDY_RS04680 ^@ http://purl.uniprot.org/uniprot/F0RYI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05370 ^@ http://purl.uniprot.org/uniprot/F0RYQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0718 family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00540 ^@ http://purl.uniprot.org/uniprot/F0RXA2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS06650 ^@ http://purl.uniprot.org/uniprot/F0RVR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/158189:SPIBUDDY_RS00230 ^@ http://purl.uniprot.org/uniprot/F0RX41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08180 ^@ http://purl.uniprot.org/uniprot/F0RW75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06645 ^@ http://purl.uniprot.org/uniprot/F0RVR6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10080 ^@ http://purl.uniprot.org/uniprot/F0RTR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10110 ^@ http://purl.uniprot.org/uniprot/F0RTS1 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS01785 ^@ http://purl.uniprot.org/uniprot/F0RXR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11340 ^@ http://purl.uniprot.org/uniprot/F0RTX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial solute-binding protein 2 family.|||Part of the ABC transporter complex LsrABCD involved in autoinducer 2 (AI-2) import. Binds AI-2 and delivers it to the LsrC and LsrD permeases.|||Periplasm|||The complex is composed of two ATP-binding proteins (LsrA), two transmembrane proteins (LsrC and LsrD) and a solute-binding protein (LsrB). http://togogenome.org/gene/158189:SPIBUDDY_RS13415 ^@ http://purl.uniprot.org/uniprot/F0RT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05815 ^@ http://purl.uniprot.org/uniprot/F0RVI4 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/158189:SPIBUDDY_RS03890 ^@ http://purl.uniprot.org/uniprot/F0RYA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/158189:SPIBUDDY_RS11740 ^@ http://purl.uniprot.org/uniprot/F0RSL9 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS00105 ^@ http://purl.uniprot.org/uniprot/F0RX17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS14330 ^@ http://purl.uniprot.org/uniprot/F0RS42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS04115 ^@ http://purl.uniprot.org/uniprot/F0RUZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MntP (TC 9.B.29) family.|||Cell inner membrane|||Probably functions as a manganese efflux pump. http://togogenome.org/gene/158189:SPIBUDDY_RS14210 ^@ http://purl.uniprot.org/uniprot/F0RS16 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/158189:SPIBUDDY_RS14995 ^@ http://purl.uniprot.org/uniprot/F0RZL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08195 ^@ http://purl.uniprot.org/uniprot/F0RW78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04255 ^@ http://purl.uniprot.org/uniprot/F0RV24 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10945 ^@ http://purl.uniprot.org/uniprot/F0RSS3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09670 ^@ http://purl.uniprot.org/uniprot/F0RWU5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the arabinose isomerase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of L-arabinose to L-ribulose. http://togogenome.org/gene/158189:SPIBUDDY_RS09830 ^@ http://purl.uniprot.org/uniprot/F0RWX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/158189:SPIBUDDY_RS08070 ^@ http://purl.uniprot.org/uniprot/F0RW52 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/158189:SPIBUDDY_RS08790 ^@ http://purl.uniprot.org/uniprot/F0RZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00625 ^@ http://purl.uniprot.org/uniprot/F0RXB8 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/158189:SPIBUDDY_RS02455 ^@ http://purl.uniprot.org/uniprot/F0RUG3 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/158189:SPIBUDDY_RS06665 ^@ http://purl.uniprot.org/uniprot/F0RVS0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/158189:SPIBUDDY_RS00305 ^@ http://purl.uniprot.org/uniprot/F0RX56 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/158189:SPIBUDDY_RS04225 ^@ http://purl.uniprot.org/uniprot/F0RV18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07510 ^@ http://purl.uniprot.org/uniprot/F0RW12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09215 ^@ http://purl.uniprot.org/uniprot/F0RWK5 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS11290 ^@ http://purl.uniprot.org/uniprot/F0RTG7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS14140 ^@ http://purl.uniprot.org/uniprot/F0RS02 ^@ Function|||Similarity ^@ Belongs to the bacterial histone-like protein family.|||Histone-like DNA-binding protein which is capable of wrapping DNA to stabilize it, and thus to prevent its denaturation under extreme environmental conditions. http://togogenome.org/gene/158189:SPIBUDDY_RS10295 ^@ http://purl.uniprot.org/uniprot/F0RTT3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS01900 ^@ http://purl.uniprot.org/uniprot/F0RXU0 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS07315 ^@ http://purl.uniprot.org/uniprot/F0RZ53 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS11605 ^@ http://purl.uniprot.org/uniprot/F0RSJ0 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/158189:SPIBUDDY_RS15295 ^@ http://purl.uniprot.org/uniprot/F0RZS6 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/158189:SPIBUDDY_RS15195 ^@ http://purl.uniprot.org/uniprot/F0RZQ6 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/158189:SPIBUDDY_RS06370 ^@ http://purl.uniprot.org/uniprot/F0RYU1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS08965 ^@ http://purl.uniprot.org/uniprot/F0RWF4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate, the first committing step of glycolysis. Uses inorganic phosphate (PPi) as phosphoryl donor instead of ATP like common ATP-dependent phosphofructokinases (ATP-PFKs), which renders the reaction reversible, and can thus function both in glycolysis and gluconeogenesis. Consistently, PPi-PFK can replace the enzymes of both the forward (ATP-PFK) and reverse (fructose-bisphosphatase (FBPase)) reactions.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-allosteric. http://togogenome.org/gene/158189:SPIBUDDY_RS06045 ^@ http://purl.uniprot.org/uniprot/F0RVM7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05660 ^@ http://purl.uniprot.org/uniprot/F0RVF4 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/158189:SPIBUDDY_RS08845 ^@ http://purl.uniprot.org/uniprot/F0RWD0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/158189:SPIBUDDY_RS08805 ^@ http://purl.uniprot.org/uniprot/F0RWC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Catalyzes the sodium-dependent uptake of extracellular L-proline.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09850 ^@ http://purl.uniprot.org/uniprot/F0RWX9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/158189:SPIBUDDY_RS02070 ^@ http://purl.uniprot.org/uniprot/F0RXX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07060 ^@ http://purl.uniprot.org/uniprot/F0RZ02 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06815 ^@ http://purl.uniprot.org/uniprot/F0RVV0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/158189:SPIBUDDY_RS02885 ^@ http://purl.uniprot.org/uniprot/F0RXY7 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/158189:SPIBUDDY_RS02635 ^@ http://purl.uniprot.org/uniprot/F0RUK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08430 ^@ http://purl.uniprot.org/uniprot/F0RZD0 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/158189:SPIBUDDY_RS12495 ^@ http://purl.uniprot.org/uniprot/F0RRM5 ^@ Function|||Similarity ^@ Belongs to the mannonate dehydratase family.|||Catalyzes the dehydration of D-mannonate. http://togogenome.org/gene/158189:SPIBUDDY_RS07000 ^@ http://purl.uniprot.org/uniprot/F0RYZ0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS12825 ^@ http://purl.uniprot.org/uniprot/F0RSE9 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Aspartase subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS05420 ^@ http://purl.uniprot.org/uniprot/F0RYQ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/158189:SPIBUDDY_RS14450 ^@ http://purl.uniprot.org/uniprot/F0RS66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/158189:SPIBUDDY_RS14605 ^@ http://purl.uniprot.org/uniprot/F0RS87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00310 ^@ http://purl.uniprot.org/uniprot/F0RX57 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/158189:SPIBUDDY_RS04550 ^@ http://purl.uniprot.org/uniprot/F0RYF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05050 ^@ http://purl.uniprot.org/uniprot/F0RVA8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06185 ^@ http://purl.uniprot.org/uniprot/F0RVQ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/158189:SPIBUDDY_RS02800 ^@ http://purl.uniprot.org/uniprot/F0RUN3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OadG family.|||Catalyzes the decarboxylation of oxaloacetate coupled to Na(+) translocation.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00125 ^@ http://purl.uniprot.org/uniprot/F0RX21 ^@ Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06110 ^@ http://purl.uniprot.org/uniprot/F0RVP0 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS08545 ^@ http://purl.uniprot.org/uniprot/F0RZF4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/158189:SPIBUDDY_RS07415 ^@ http://purl.uniprot.org/uniprot/F0RVZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS07180 ^@ http://purl.uniprot.org/uniprot/F0RZ26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/158189:SPIBUDDY_RS03325 ^@ http://purl.uniprot.org/uniprot/F0RUR3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/158189:SPIBUDDY_RS12295 ^@ http://purl.uniprot.org/uniprot/F0RRJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14670 ^@ http://purl.uniprot.org/uniprot/F0RSA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YajC family.|||Cell inner membrane|||Membrane|||Part of the SecDF-YidC-YajC translocase complex. The SecDF-YidC-YajC translocase forms a supercomplex with SecYEG, called the holo-translocon (HTL).|||The SecYEG-SecDF-YajC-YidC holo-translocon (HTL) protein secretase/insertase is a supercomplex required for protein secretion, insertion of proteins into membranes, and assembly of membrane protein complexes. While the SecYEG complex is essential for assembly of a number of proteins and complexes, the SecDF-YajC-YidC subcomplex facilitates these functions. http://togogenome.org/gene/158189:SPIBUDDY_RS14250 ^@ http://purl.uniprot.org/uniprot/F0RS24 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/158189:SPIBUDDY_RS14130 ^@ http://purl.uniprot.org/uniprot/F0RS00 ^@ Similarity ^@ Belongs to the CinA family. http://togogenome.org/gene/158189:SPIBUDDY_RS03200 ^@ http://purl.uniprot.org/uniprot/F0RY42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04090 ^@ http://purl.uniprot.org/uniprot/F0RUZ1 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/158189:SPIBUDDY_RS00035 ^@ http://purl.uniprot.org/uniprot/F0RX03 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Cell inner membrane|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/158189:SPIBUDDY_RS14350 ^@ http://purl.uniprot.org/uniprot/F0RS46 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS06205 ^@ http://purl.uniprot.org/uniprot/F0RYR5 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS10560 ^@ http://purl.uniprot.org/uniprot/F0RTJ1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS11760 ^@ http://purl.uniprot.org/uniprot/F0RSN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/158189:SPIBUDDY_RS03670 ^@ http://purl.uniprot.org/uniprot/F0RY60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12480 ^@ http://purl.uniprot.org/uniprot/F0RRM2 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02420 ^@ http://purl.uniprot.org/uniprot/F0RUF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02035 ^@ http://purl.uniprot.org/uniprot/F0RXW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06430 ^@ http://purl.uniprot.org/uniprot/F0RYV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06600 ^@ http://purl.uniprot.org/uniprot/F0RVQ8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14460 ^@ http://purl.uniprot.org/uniprot/F0RS67 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/158189:SPIBUDDY_RS02910 ^@ http://purl.uniprot.org/uniprot/F0RXZ2 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/158189:SPIBUDDY_RS06170 ^@ http://purl.uniprot.org/uniprot/F0RVQ2 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10905 ^@ http://purl.uniprot.org/uniprot/F0RSR5 ^@ Cofactor ^@ Binds 1 FAD per subunit.|||Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS14020 ^@ http://purl.uniprot.org/uniprot/F0RRX9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09900 ^@ http://purl.uniprot.org/uniprot/F0RWY8 ^@ Function|||Similarity ^@ Belongs to the desulfoferrodoxin family.|||Catalyzes the one-electron reduction of superoxide anion radical to hydrogen peroxide at a nonheme ferrous iron center. Plays a fundamental role in case of oxidative stress via its superoxide detoxification activity. http://togogenome.org/gene/158189:SPIBUDDY_RS01720 ^@ http://purl.uniprot.org/uniprot/F0RU95 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS07090 ^@ http://purl.uniprot.org/uniprot/F0RZ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/158189:SPIBUDDY_RS05615 ^@ http://purl.uniprot.org/uniprot/F0RVE5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS06305 ^@ http://purl.uniprot.org/uniprot/F0RYT5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02960 ^@ http://purl.uniprot.org/uniprot/F0RY02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05440 ^@ http://purl.uniprot.org/uniprot/F0RVB4 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/158189:SPIBUDDY_RS13885 ^@ http://purl.uniprot.org/uniprot/F0RRV2 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09680 ^@ http://purl.uniprot.org/uniprot/F0RWU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14765 ^@ http://purl.uniprot.org/uniprot/F0RTM5 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/158189:SPIBUDDY_RS12475 ^@ http://purl.uniprot.org/uniprot/F0RRM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04375 ^@ http://purl.uniprot.org/uniprot/F0RYC7 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS05445 ^@ http://purl.uniprot.org/uniprot/F0RVB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/158189:SPIBUDDY_RS03440 ^@ http://purl.uniprot.org/uniprot/F0RUT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04535 ^@ http://purl.uniprot.org/uniprot/F0RYF5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS15400 ^@ http://purl.uniprot.org/uniprot/F0RZU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/158189:SPIBUDDY_RS00095 ^@ http://purl.uniprot.org/uniprot/F0RX15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/158189:SPIBUDDY_RS04380 ^@ http://purl.uniprot.org/uniprot/F0RYC8 ^@ Similarity ^@ Belongs to the UPF0597 family. http://togogenome.org/gene/158189:SPIBUDDY_RS11325 ^@ http://purl.uniprot.org/uniprot/F0RTX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01905 ^@ http://purl.uniprot.org/uniprot/F0RXU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS03320 ^@ http://purl.uniprot.org/uniprot/F0RUR2 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS14375 ^@ http://purl.uniprot.org/uniprot/F0RS51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/158189:SPIBUDDY_RS12040 ^@ http://purl.uniprot.org/uniprot/F0RRD7 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05650 ^@ http://purl.uniprot.org/uniprot/F0RVF2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/158189:SPIBUDDY_RS00580 ^@ http://purl.uniprot.org/uniprot/F0RXA9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06125 ^@ http://purl.uniprot.org/uniprot/F0RVP3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS05045 ^@ http://purl.uniprot.org/uniprot/F0RVA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00855 ^@ http://purl.uniprot.org/uniprot/F0RXG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06825 ^@ http://purl.uniprot.org/uniprot/F0RVV2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfB subfamily.|||Binds 3 [4Fe-4S] clusters.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/158189:SPIBUDDY_RS05600 ^@ http://purl.uniprot.org/uniprot/F0RVE2 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04475 ^@ http://purl.uniprot.org/uniprot/F0RYE5 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS13810 ^@ http://purl.uniprot.org/uniprot/F0RRT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15330 ^@ http://purl.uniprot.org/uniprot/F0RZT3 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05665 ^@ http://purl.uniprot.org/uniprot/F0RVF5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/158189:SPIBUDDY_RS15475 ^@ http://purl.uniprot.org/uniprot/F0RZV6 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/158189:SPIBUDDY_RS14320 ^@ http://purl.uniprot.org/uniprot/F0RS39 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/158189:SPIBUDDY_RS16190 ^@ http://purl.uniprot.org/uniprot/F0RWZ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS12770 ^@ http://purl.uniprot.org/uniprot/F0RSD8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10755 ^@ http://purl.uniprot.org/uniprot/F0RSY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS07155 ^@ http://purl.uniprot.org/uniprot/F0RZ21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/158189:SPIBUDDY_RS08610 ^@ http://purl.uniprot.org/uniprot/F0RZG7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/158189:SPIBUDDY_RS01200 ^@ http://purl.uniprot.org/uniprot/F0RXN0 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS07730 ^@ http://purl.uniprot.org/uniprot/F0RZ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14370 ^@ http://purl.uniprot.org/uniprot/F0RS50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/158189:SPIBUDDY_RS02030 ^@ http://purl.uniprot.org/uniprot/F0RXW4 ^@ Function ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins. http://togogenome.org/gene/158189:SPIBUDDY_RS07435 ^@ http://purl.uniprot.org/uniprot/F0RVZ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02905 ^@ http://purl.uniprot.org/uniprot/F0RXZ1 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS07635 ^@ http://purl.uniprot.org/uniprot/F0RW36 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS11465 ^@ http://purl.uniprot.org/uniprot/F0RTZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06215 ^@ http://purl.uniprot.org/uniprot/F0RYR7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS14100 ^@ http://purl.uniprot.org/uniprot/F0RRZ4 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00535 ^@ http://purl.uniprot.org/uniprot/F0RXA1 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS05240 ^@ http://purl.uniprot.org/uniprot/F0RYM3 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10750 ^@ http://purl.uniprot.org/uniprot/F0RSY8 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS02275 ^@ http://purl.uniprot.org/uniprot/F0RUC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04790 ^@ http://purl.uniprot.org/uniprot/F0RV56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/158189:SPIBUDDY_RS08270 ^@ http://purl.uniprot.org/uniprot/F0RW93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07495 ^@ http://purl.uniprot.org/uniprot/F0RW09 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS05800 ^@ http://purl.uniprot.org/uniprot/F0RVI1 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type alpha chain is a catalytic subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS10380 ^@ http://purl.uniprot.org/uniprot/F0RU05 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04595 ^@ http://purl.uniprot.org/uniprot/F0RYG8 ^@ Similarity ^@ Belongs to the TrpR family. http://togogenome.org/gene/158189:SPIBUDDY_RS02530 ^@ http://purl.uniprot.org/uniprot/F0RUH8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10580 ^@ http://purl.uniprot.org/uniprot/F0RTJ5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/158189:SPIBUDDY_RS14325 ^@ http://purl.uniprot.org/uniprot/F0RS41 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/158189:SPIBUDDY_RS04685 ^@ http://purl.uniprot.org/uniprot/F0RYI5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14305 ^@ http://purl.uniprot.org/uniprot/F0RS36 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/158189:SPIBUDDY_RS12720 ^@ http://purl.uniprot.org/uniprot/F0RSC9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10695 ^@ http://purl.uniprot.org/uniprot/F0RSX8 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS06805 ^@ http://purl.uniprot.org/uniprot/F0RVU8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrB/RnfD family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/158189:SPIBUDDY_RS00700 ^@ http://purl.uniprot.org/uniprot/F0RXD2 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS06780 ^@ http://purl.uniprot.org/uniprot/F0RVU3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS07170 ^@ http://purl.uniprot.org/uniprot/F0RZ24 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/158189:SPIBUDDY_RS07845 ^@ http://purl.uniprot.org/uniprot/F0RZ83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07175 ^@ http://purl.uniprot.org/uniprot/F0RZ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS04340 ^@ http://purl.uniprot.org/uniprot/F0RV40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the encapsulin family. Family 1 subfamily.|||Encapsulin nanocompartment http://togogenome.org/gene/158189:SPIBUDDY_RS03700 ^@ http://purl.uniprot.org/uniprot/F0RY66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10055 ^@ http://purl.uniprot.org/uniprot/F0RTR0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/158189:SPIBUDDY_RS00670 ^@ http://purl.uniprot.org/uniprot/F0RXC7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10685 ^@ http://purl.uniprot.org/uniprot/F0RSN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06150 ^@ http://purl.uniprot.org/uniprot/F0RVP8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS12505 ^@ http://purl.uniprot.org/uniprot/F0RRM7 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11630 ^@ http://purl.uniprot.org/uniprot/F0RSJ5 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14310 ^@ http://purl.uniprot.org/uniprot/F0RS37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/158189:SPIBUDDY_RS13370 ^@ http://purl.uniprot.org/uniprot/F0RT64 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06425 ^@ http://purl.uniprot.org/uniprot/F0RYV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08010 ^@ http://purl.uniprot.org/uniprot/F0RZB6 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14270 ^@ http://purl.uniprot.org/uniprot/F0RS28 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/158189:SPIBUDDY_RS08735 ^@ http://purl.uniprot.org/uniprot/F0RZJ0 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/158189:SPIBUDDY_RS15620 ^@ http://purl.uniprot.org/uniprot/F0RUU1 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS00200 ^@ http://purl.uniprot.org/uniprot/F0RX35 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00990 ^@ http://purl.uniprot.org/uniprot/F0RXI9 ^@ Similarity ^@ Belongs to the short-chain fatty acyl-CoA assimilation regulator (ScfR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS14520 ^@ http://purl.uniprot.org/uniprot/F0RS79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nlpA lipoprotein family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11490 ^@ http://purl.uniprot.org/uniprot/F0RSG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13965 ^@ http://purl.uniprot.org/uniprot/F0RRW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08370 ^@ http://purl.uniprot.org/uniprot/F0RWB3 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/158189:SPIBUDDY_RS12430 ^@ http://purl.uniprot.org/uniprot/F0RRL2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. Sucrose phosphorylase subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS09740 ^@ http://purl.uniprot.org/uniprot/F0RWV9 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/158189:SPIBUDDY_RS03340 ^@ http://purl.uniprot.org/uniprot/F0RUR6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family.|||In the N-terminal section; belongs to the histidinol-phosphatase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS15595 ^@ http://purl.uniprot.org/uniprot/F0RY00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB family.|||Cell inner membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14395 ^@ http://purl.uniprot.org/uniprot/F0RS55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/158189:SPIBUDDY_RS13305 ^@ http://purl.uniprot.org/uniprot/F0RT86 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS09960 ^@ http://purl.uniprot.org/uniprot/F0RZX0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. CpsB/CapC family. http://togogenome.org/gene/158189:SPIBUDDY_RS02240 ^@ http://purl.uniprot.org/uniprot/F0RUC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00235 ^@ http://purl.uniprot.org/uniprot/F0RX42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02510 ^@ http://purl.uniprot.org/uniprot/F0RUH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01595 ^@ http://purl.uniprot.org/uniprot/F0RU71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12450 ^@ http://purl.uniprot.org/uniprot/F0RRL6 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 1 family. http://togogenome.org/gene/158189:SPIBUDDY_RS00920 ^@ http://purl.uniprot.org/uniprot/F0RXH5 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS06505 ^@ http://purl.uniprot.org/uniprot/F0RYW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07770 ^@ http://purl.uniprot.org/uniprot/F0RZ68 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/158189:SPIBUDDY_RS01130 ^@ http://purl.uniprot.org/uniprot/F0RXL6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS05565 ^@ http://purl.uniprot.org/uniprot/F0RVD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/158189:SPIBUDDY_RS04095 ^@ http://purl.uniprot.org/uniprot/F0RUZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS11185 ^@ http://purl.uniprot.org/uniprot/F0RSW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06785 ^@ http://purl.uniprot.org/uniprot/F0RVU4 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06475 ^@ http://purl.uniprot.org/uniprot/F0RYW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||ATPase subunit of a proteasome-like degradation complex; this subunit has chaperone activity. The binding of ATP and its subsequent hydrolysis by HslU are essential for unfolding of protein substrates subsequently hydrolyzed by HslV. HslU recognizes the N-terminal part of its protein substrates and unfolds these before they are guided to HslV for hydrolysis.|||Belongs to the ClpX chaperone family. HslU subfamily.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS01735 ^@ http://purl.uniprot.org/uniprot/F0RXQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14430 ^@ http://purl.uniprot.org/uniprot/F0RS62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/158189:SPIBUDDY_RS03515 ^@ http://purl.uniprot.org/uniprot/F0RUV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07065 ^@ http://purl.uniprot.org/uniprot/F0RZ03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12365 ^@ http://purl.uniprot.org/uniprot/F0RRJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04205 ^@ http://purl.uniprot.org/uniprot/F0RV14 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/158189:SPIBUDDY_RS13490 ^@ http://purl.uniprot.org/uniprot/F0RT34 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03100 ^@ http://purl.uniprot.org/uniprot/F0RY24 ^@ Function|||Similarity ^@ Belongs to the transposase 11 family.|||Involved in the transposition of the insertion sequence IS5. http://togogenome.org/gene/158189:SPIBUDDY_RS06605 ^@ http://purl.uniprot.org/uniprot/F0RVQ9 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/158189:SPIBUDDY_RS07645 ^@ http://purl.uniprot.org/uniprot/F0RW38 ^@ Function|||Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. SpeA subfamily.|||Catalyzes the biosynthesis of agmatine from arginine. http://togogenome.org/gene/158189:SPIBUDDY_RS06910 ^@ http://purl.uniprot.org/uniprot/F0RVW9 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS09175 ^@ http://purl.uniprot.org/uniprot/F0RWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02270 ^@ http://purl.uniprot.org/uniprot/F0RUC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00275 ^@ http://purl.uniprot.org/uniprot/F0RX50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15425 ^@ http://purl.uniprot.org/uniprot/F0RZU7 ^@ Cofactor|||Similarity ^@ Belongs to the UPF0313 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/158189:SPIBUDDY_RS04850 ^@ http://purl.uniprot.org/uniprot/F0RV68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14490 ^@ http://purl.uniprot.org/uniprot/F0RS72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/158189:SPIBUDDY_RS07705 ^@ http://purl.uniprot.org/uniprot/F0RW50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08415 ^@ http://purl.uniprot.org/uniprot/F0RWC2 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/158189:SPIBUDDY_RS14830 ^@ http://purl.uniprot.org/uniprot/F0RTN8 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/158189:SPIBUDDY_RS14385 ^@ http://purl.uniprot.org/uniprot/F0RS53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/158189:SPIBUDDY_RS07430 ^@ http://purl.uniprot.org/uniprot/F0RVZ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS14145 ^@ http://purl.uniprot.org/uniprot/F0RS03 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/158189:SPIBUDDY_RS14135 ^@ http://purl.uniprot.org/uniprot/F0RS01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CN hydrolase family. Apolipoprotein N-acyltransferase subfamily.|||Catalyzes the phospholipid dependent N-acylation of the N-terminal cysteine of apolipoprotein, the last step in lipoprotein maturation.|||Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11480 ^@ http://purl.uniprot.org/uniprot/F0RSG6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10275 ^@ http://purl.uniprot.org/uniprot/F0RTS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14010 ^@ http://purl.uniprot.org/uniprot/F0RRX7 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/158189:SPIBUDDY_RS07915 ^@ http://purl.uniprot.org/uniprot/F0RZ97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04425 ^@ http://purl.uniprot.org/uniprot/F0RYD5 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/158189:SPIBUDDY_RS03275 ^@ http://purl.uniprot.org/uniprot/F0RUQ3 ^@ Similarity ^@ Belongs to the UPF0251 family. http://togogenome.org/gene/158189:SPIBUDDY_RS02375 ^@ http://purl.uniprot.org/uniprot/F0RUE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS13710 ^@ http://purl.uniprot.org/uniprot/F0RSB3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS03300 ^@ http://purl.uniprot.org/uniprot/F0RUQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS04065 ^@ http://purl.uniprot.org/uniprot/F0RUY6 ^@ Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05900 ^@ http://purl.uniprot.org/uniprot/F0RVJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11695 ^@ http://purl.uniprot.org/uniprot/F0RSK9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS09125 ^@ http://purl.uniprot.org/uniprot/F0RWI7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14120 ^@ http://purl.uniprot.org/uniprot/F0RRZ8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02675 ^@ http://purl.uniprot.org/uniprot/F0RUK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10915 ^@ http://purl.uniprot.org/uniprot/F0RSR7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/158189:SPIBUDDY_RS01180 ^@ http://purl.uniprot.org/uniprot/F0RXM6 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS14715 ^@ http://purl.uniprot.org/uniprot/F0RTL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS02450 ^@ http://purl.uniprot.org/uniprot/F0RUG2 ^@ Similarity ^@ Belongs to the ETF beta-subunit/FixA family. http://togogenome.org/gene/158189:SPIBUDDY_RS14750 ^@ http://purl.uniprot.org/uniprot/F0RTM2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Atypical ATP-dependent clade 'X' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS00930 ^@ http://purl.uniprot.org/uniprot/F0RXH7 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS15320 ^@ http://purl.uniprot.org/uniprot/F0RZT1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/158189:SPIBUDDY_RS03785 ^@ http://purl.uniprot.org/uniprot/F0RY83 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08465 ^@ http://purl.uniprot.org/uniprot/F0RZD8 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS03910 ^@ http://purl.uniprot.org/uniprot/F0RYA8 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HPrK/P family.|||Both phosphorylation and phosphorolysis are carried out by the same active site and suggest a common mechanism for both reactions.|||Catalyzes the ATP- as well as the pyrophosphate-dependent phosphorylation of a specific serine residue in HPr, a phosphocarrier protein of the phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS). HprK/P also catalyzes the pyrophosphate-producing, inorganic phosphate-dependent dephosphorylation (phosphorolysis) of seryl-phosphorylated HPr (P-Ser-HPr).|||Homohexamer.|||The Walker A ATP-binding motif also binds Pi and PPi. http://togogenome.org/gene/158189:SPIBUDDY_RS00925 ^@ http://purl.uniprot.org/uniprot/F0RXH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06130 ^@ http://purl.uniprot.org/uniprot/F0RVP4 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/158189:SPIBUDDY_RS03720 ^@ http://purl.uniprot.org/uniprot/F0RY70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01290 ^@ http://purl.uniprot.org/uniprot/F0RXP7 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/158189:SPIBUDDY_RS10955 ^@ http://purl.uniprot.org/uniprot/F0RSS5 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/158189:SPIBUDDY_RS10830 ^@ http://purl.uniprot.org/uniprot/F0RT05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12235 ^@ http://purl.uniprot.org/uniprot/F0RRH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07230 ^@ http://purl.uniprot.org/uniprot/F0RZ36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS06675 ^@ http://purl.uniprot.org/uniprot/F0RVS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS03015 ^@ http://purl.uniprot.org/uniprot/F0RY09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13035 ^@ http://purl.uniprot.org/uniprot/F0RT89 ^@ Similarity ^@ Belongs to the radical SAM superfamily. KamA family. http://togogenome.org/gene/158189:SPIBUDDY_RS14260 ^@ http://purl.uniprot.org/uniprot/F0RS26 ^@ Function|||Similarity ^@ Belongs to the RNase Y family.|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/158189:SPIBUDDY_RS14075 ^@ http://purl.uniprot.org/uniprot/F0RRY9 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/158189:SPIBUDDY_RS07305 ^@ http://purl.uniprot.org/uniprot/F0RZ51 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15250 ^@ http://purl.uniprot.org/uniprot/F0RZR7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02140 ^@ http://purl.uniprot.org/uniprot/F0RUA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11805 ^@ http://purl.uniprot.org/uniprot/F0RSM8 ^@ Function|||Similarity ^@ Belongs to the RlpA family.|||Lytic transglycosylase with a strong preference for naked glycan strands that lack stem peptides. http://togogenome.org/gene/158189:SPIBUDDY_RS06245 ^@ http://purl.uniprot.org/uniprot/F0RYS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell inner membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/158189:SPIBUDDY_RS09825 ^@ http://purl.uniprot.org/uniprot/F0RWX4 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06560 ^@ http://purl.uniprot.org/uniprot/F0RYX9 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/158189:SPIBUDDY_RS14215 ^@ http://purl.uniprot.org/uniprot/F0RS17 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/158189:SPIBUDDY_RS05330 ^@ http://purl.uniprot.org/uniprot/F0RYP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02100 ^@ http://purl.uniprot.org/uniprot/F0RXX8 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10300 ^@ http://purl.uniprot.org/uniprot/F0RTT4 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11575 ^@ http://purl.uniprot.org/uniprot/F0RSI5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00055 ^@ http://purl.uniprot.org/uniprot/F0RX07 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/158189:SPIBUDDY_RS04750 ^@ http://purl.uniprot.org/uniprot/F0RV48 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/158189:SPIBUDDY_RS03545 ^@ http://purl.uniprot.org/uniprot/F0RUV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11065 ^@ http://purl.uniprot.org/uniprot/F0RSU6 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS01935 ^@ http://purl.uniprot.org/uniprot/F0RXU7 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. dTDP-glucose dehydratase subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS08945 ^@ http://purl.uniprot.org/uniprot/F0RWF0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS06630 ^@ http://purl.uniprot.org/uniprot/F0RVR3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/158189:SPIBUDDY_RS07450 ^@ http://purl.uniprot.org/uniprot/F0RW01 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/158189:SPIBUDDY_RS04820 ^@ http://purl.uniprot.org/uniprot/F0RV62 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS06800 ^@ http://purl.uniprot.org/uniprot/F0RVU7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/158189:SPIBUDDY_RS14945 ^@ http://purl.uniprot.org/uniprot/F0RZK7 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS00620 ^@ http://purl.uniprot.org/uniprot/F0RXB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS14900 ^@ http://purl.uniprot.org/uniprot/F0RTQ1 ^@ Similarity ^@ Belongs to the CarB family. http://togogenome.org/gene/158189:SPIBUDDY_RS00960 ^@ http://purl.uniprot.org/uniprot/F0RXI3 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS11880 ^@ http://purl.uniprot.org/uniprot/F0RSQ4 ^@ Similarity ^@ Belongs to the helicase family. DnaB subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS03675 ^@ http://purl.uniprot.org/uniprot/F0RY61 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 51 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08695 ^@ http://purl.uniprot.org/uniprot/F0RZI3 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03870 ^@ http://purl.uniprot.org/uniprot/F0RYA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02705 ^@ http://purl.uniprot.org/uniprot/F0RUL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08115 ^@ http://purl.uniprot.org/uniprot/F0RW61 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS14125 ^@ http://purl.uniprot.org/uniprot/F0RRZ9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS04275 ^@ http://purl.uniprot.org/uniprot/F0RV28 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10990 ^@ http://purl.uniprot.org/uniprot/F0RST2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05710 ^@ http://purl.uniprot.org/uniprot/F0RVG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07700 ^@ http://purl.uniprot.org/uniprot/F0RW49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15450 ^@ http://purl.uniprot.org/uniprot/F0RZV1 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS16185 ^@ http://purl.uniprot.org/uniprot/F0RWZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS05350 ^@ http://purl.uniprot.org/uniprot/F0RYP6 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/158189:SPIBUDDY_RS13495 ^@ http://purl.uniprot.org/uniprot/F0RT35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00490 ^@ http://purl.uniprot.org/uniprot/F0RX93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13460 ^@ http://purl.uniprot.org/uniprot/F0RT30 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS01830 ^@ http://purl.uniprot.org/uniprot/F0RXS6 ^@ Similarity ^@ Belongs to the bacterial sugar transferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14400 ^@ http://purl.uniprot.org/uniprot/F0RS56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/158189:SPIBUDDY_RS11530 ^@ http://purl.uniprot.org/uniprot/F0RSH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01285 ^@ http://purl.uniprot.org/uniprot/F0RXP6 ^@ Similarity ^@ Belongs to the polysaccharide synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03070 ^@ http://purl.uniprot.org/uniprot/F0RY20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06390 ^@ http://purl.uniprot.org/uniprot/F0RYU5 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06635 ^@ http://purl.uniprot.org/uniprot/F0RVR4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/158189:SPIBUDDY_RS13410 ^@ http://purl.uniprot.org/uniprot/F0RT18 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS06495 ^@ http://purl.uniprot.org/uniprot/F0RYW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/158189:SPIBUDDY_RS04485 ^@ http://purl.uniprot.org/uniprot/F0RYE7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/158189:SPIBUDDY_RS03695 ^@ http://purl.uniprot.org/uniprot/F0RY65 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04110 ^@ http://purl.uniprot.org/uniprot/F0RUZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12725 ^@ http://purl.uniprot.org/uniprot/F0RSD0 ^@ Function|||Similarity ^@ Belongs to the anhydro-N-acetylmuramic acid kinase family.|||Catalyzes the specific phosphorylation of 1,6-anhydro-N-acetylmuramic acid (anhMurNAc) with the simultaneous cleavage of the 1,6-anhydro ring, generating MurNAc-6-P. Is required for the utilization of anhMurNAc either imported from the medium or derived from its own cell wall murein, and thus plays a role in cell wall recycling. http://togogenome.org/gene/158189:SPIBUDDY_RS13095 ^@ http://purl.uniprot.org/uniprot/F0RTA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12360 ^@ http://purl.uniprot.org/uniprot/F0RRJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09710 ^@ http://purl.uniprot.org/uniprot/F0RWV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13235 ^@ http://purl.uniprot.org/uniprot/F0RTE7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14650 ^@ http://purl.uniprot.org/uniprot/F0RS96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/158189:SPIBUDDY_RS08325 ^@ http://purl.uniprot.org/uniprot/F0RWA4 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/158189:SPIBUDDY_RS12255 ^@ http://purl.uniprot.org/uniprot/F0RRI3 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS02355 ^@ http://purl.uniprot.org/uniprot/F0RUE3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/158189:SPIBUDDY_RS08250 ^@ http://purl.uniprot.org/uniprot/F0RW89 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14080 ^@ http://purl.uniprot.org/uniprot/F0RRZ0 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/158189:SPIBUDDY_RS15245 ^@ http://purl.uniprot.org/uniprot/F0RZR6 ^@ Similarity ^@ Belongs to the UxaA family. http://togogenome.org/gene/158189:SPIBUDDY_RS03245 ^@ http://purl.uniprot.org/uniprot/F0RUP7 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS02170 ^@ http://purl.uniprot.org/uniprot/F0RUA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06195 ^@ http://purl.uniprot.org/uniprot/F0RYR3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10045 ^@ http://purl.uniprot.org/uniprot/F0RTQ8 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/158189:SPIBUDDY_RS06685 ^@ http://purl.uniprot.org/uniprot/F0RVS4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS09040 ^@ http://purl.uniprot.org/uniprot/F0RWG9 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04860 ^@ http://purl.uniprot.org/uniprot/F0RV70 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00140 ^@ http://purl.uniprot.org/uniprot/F0RX24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10305 ^@ http://purl.uniprot.org/uniprot/F0RTT5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00030 ^@ http://purl.uniprot.org/uniprot/F0RX02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/158189:SPIBUDDY_RS04250 ^@ http://purl.uniprot.org/uniprot/F0RV23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11115 ^@ http://purl.uniprot.org/uniprot/F0RSV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03630 ^@ http://purl.uniprot.org/uniprot/F0RY52 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS00665 ^@ http://purl.uniprot.org/uniprot/F0RXC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01925 ^@ http://purl.uniprot.org/uniprot/F0RXU5 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/158189:SPIBUDDY_RS14905 ^@ http://purl.uniprot.org/uniprot/F0RTQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS08825 ^@ http://purl.uniprot.org/uniprot/F0RWC8 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/158189:SPIBUDDY_RS12385 ^@ http://purl.uniprot.org/uniprot/F0RRK2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/158189:SPIBUDDY_RS07520 ^@ http://purl.uniprot.org/uniprot/F0RW14 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H family.|||Binds 1 Mg(2+) ion per subunit. May bind a second metal ion at a regulatory site, or after substrate binding.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS02175 ^@ http://purl.uniprot.org/uniprot/F0RUA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01165 ^@ http://purl.uniprot.org/uniprot/F0RXM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14295 ^@ http://purl.uniprot.org/uniprot/F0RS34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS09845 ^@ http://purl.uniprot.org/uniprot/F0RWX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/158189:SPIBUDDY_RS11800 ^@ http://purl.uniprot.org/uniprot/F0RSM7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS15480 ^@ http://purl.uniprot.org/uniprot/F0RZV7 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06950 ^@ http://purl.uniprot.org/uniprot/F0RVX5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/158189:SPIBUDDY_RS07820 ^@ http://purl.uniprot.org/uniprot/F0RZ78 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it has been shown that conserved amino acid substitutions in the substrate binding pocket convert the substrate specificity of this enzyme from 6-aminopurines to 6-oxopurines.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase which is highly specific for 6-oxopurine nucleosides. Cleaves guanosine or inosine to respective bases and sugar-1-phosphate molecules. Involved in purine salvage. http://togogenome.org/gene/158189:SPIBUDDY_RS00825 ^@ http://purl.uniprot.org/uniprot/F0RXF7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/158189:SPIBUDDY_RS04060 ^@ http://purl.uniprot.org/uniprot/F0RUY5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09220 ^@ http://purl.uniprot.org/uniprot/F0RWK6 ^@ Similarity ^@ Belongs to the xanthine dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03345 ^@ http://purl.uniprot.org/uniprot/F0RUR7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/158189:SPIBUDDY_RS11265 ^@ http://purl.uniprot.org/uniprot/F0RTG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06700 ^@ http://purl.uniprot.org/uniprot/F0RVS7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS15185 ^@ http://purl.uniprot.org/uniprot/F0RZQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00120 ^@ http://purl.uniprot.org/uniprot/F0RX20 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/158189:SPIBUDDY_RS03645 ^@ http://purl.uniprot.org/uniprot/F0RY55 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/158189:SPIBUDDY_RS06140 ^@ http://purl.uniprot.org/uniprot/F0RVP6 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS03315 ^@ http://purl.uniprot.org/uniprot/F0RUR1 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/158189:SPIBUDDY_RS02120 ^@ http://purl.uniprot.org/uniprot/F0RXY2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07210 ^@ http://purl.uniprot.org/uniprot/F0RZ32 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/158189:SPIBUDDY_RS00545 ^@ http://purl.uniprot.org/uniprot/F0RXA3 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05795 ^@ http://purl.uniprot.org/uniprot/F0RVI0 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS15075 ^@ http://purl.uniprot.org/uniprot/F0RZN3 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS08400 ^@ http://purl.uniprot.org/uniprot/F0RWB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12275 ^@ http://purl.uniprot.org/uniprot/F0RRI7 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11170 ^@ http://purl.uniprot.org/uniprot/F0RSW5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS13905 ^@ http://purl.uniprot.org/uniprot/F0RRV6 ^@ Similarity ^@ Belongs to the creatininase superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS04670 ^@ http://purl.uniprot.org/uniprot/F0RYI2 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/158189:SPIBUDDY_RS01100 ^@ http://purl.uniprot.org/uniprot/F0RXL1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the selenophosphate synthase 1 family. Class I subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Homodimer.|||Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/158189:SPIBUDDY_RS11485 ^@ http://purl.uniprot.org/uniprot/F0RSG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14835 ^@ http://purl.uniprot.org/uniprot/F0RTN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06715 ^@ http://purl.uniprot.org/uniprot/F0RVT0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10650 ^@ http://purl.uniprot.org/uniprot/F0RTK8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS08550 ^@ http://purl.uniprot.org/uniprot/F0RZF5 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/158189:SPIBUDDY_RS07385 ^@ http://purl.uniprot.org/uniprot/F0RVY8 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS04005 ^@ http://purl.uniprot.org/uniprot/F0RUX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RlmKL family.|||Cytoplasm|||Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS01035 ^@ http://purl.uniprot.org/uniprot/F0RXJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06410 ^@ http://purl.uniprot.org/uniprot/F0RYU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS07215 ^@ http://purl.uniprot.org/uniprot/F0RZ33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02540 ^@ http://purl.uniprot.org/uniprot/F0RUI1 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS00440 ^@ http://purl.uniprot.org/uniprot/F0RX83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15165 ^@ http://purl.uniprot.org/uniprot/F0RZQ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS12270 ^@ http://purl.uniprot.org/uniprot/F0RRI6 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS05995 ^@ http://purl.uniprot.org/uniprot/F0RVL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03455 ^@ http://purl.uniprot.org/uniprot/F0RUT9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10535 ^@ http://purl.uniprot.org/uniprot/F0RTF5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS13320 ^@ http://purl.uniprot.org/uniprot/F0RT97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06445 ^@ http://purl.uniprot.org/uniprot/F0RYV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/158189:SPIBUDDY_RS03395 ^@ http://purl.uniprot.org/uniprot/F0RUS7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/158189:SPIBUDDY_RS02345 ^@ http://purl.uniprot.org/uniprot/F0RUE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS07945 ^@ http://purl.uniprot.org/uniprot/F0RZA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11775 ^@ http://purl.uniprot.org/uniprot/F0RSM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/158189:SPIBUDDY_RS06925 ^@ http://purl.uniprot.org/uniprot/F0RVX2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS05455 ^@ http://purl.uniprot.org/uniprot/F0RVB7 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/158189:SPIBUDDY_RS04635 ^@ http://purl.uniprot.org/uniprot/F0RYH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05140 ^@ http://purl.uniprot.org/uniprot/F0RYK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10940 ^@ http://purl.uniprot.org/uniprot/F0RSS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS12710 ^@ http://purl.uniprot.org/uniprot/F0RSC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10995 ^@ http://purl.uniprot.org/uniprot/F0RST3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03355 ^@ http://purl.uniprot.org/uniprot/F0RUR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS11460 ^@ http://purl.uniprot.org/uniprot/F0RTZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06365 ^@ http://purl.uniprot.org/uniprot/F0RYU0 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/158189:SPIBUDDY_RS05680 ^@ http://purl.uniprot.org/uniprot/F0RVF8 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14610 ^@ http://purl.uniprot.org/uniprot/F0RS88 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/158189:SPIBUDDY_RS11455 ^@ http://purl.uniprot.org/uniprot/F0RTZ6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14865 ^@ http://purl.uniprot.org/uniprot/F0RTP5 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/158189:SPIBUDDY_RS12210 ^@ http://purl.uniprot.org/uniprot/F0RRH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04930 ^@ http://purl.uniprot.org/uniprot/F0RV84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13290 ^@ http://purl.uniprot.org/uniprot/F0RT59 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/158189:SPIBUDDY_RS00015 ^@ http://purl.uniprot.org/uniprot/F0RWZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/158189:SPIBUDDY_RS00660 ^@ http://purl.uniprot.org/uniprot/F0RXC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04235 ^@ http://purl.uniprot.org/uniprot/F0RV20 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS10925 ^@ http://purl.uniprot.org/uniprot/F0RSR9 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/158189:SPIBUDDY_RS06820 ^@ http://purl.uniprot.org/uniprot/F0RVV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NqrDE/RnfAE family.|||Cell inner membrane|||Membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/158189:SPIBUDDY_RS11180 ^@ http://purl.uniprot.org/uniprot/F0RSW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09050 ^@ http://purl.uniprot.org/uniprot/F0RWH1 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/158189:SPIBUDDY_RS02370 ^@ http://purl.uniprot.org/uniprot/F0RUE6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14970 ^@ http://purl.uniprot.org/uniprot/F0RZL2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS14345 ^@ http://purl.uniprot.org/uniprot/F0RS45 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/158189:SPIBUDDY_RS04195 ^@ http://purl.uniprot.org/uniprot/F0RV12 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/158189:SPIBUDDY_RS10640 ^@ http://purl.uniprot.org/uniprot/F0RTK6 ^@ Function ^@ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. http://togogenome.org/gene/158189:SPIBUDDY_RS14185 ^@ http://purl.uniprot.org/uniprot/F0RS11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09140 ^@ http://purl.uniprot.org/uniprot/F0RWJ0 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/158189:SPIBUDDY_RS05510 ^@ http://purl.uniprot.org/uniprot/F0RVC3 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS06500 ^@ http://purl.uniprot.org/uniprot/F0RYW7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS02260 ^@ http://purl.uniprot.org/uniprot/F0RUC4 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/158189:SPIBUDDY_RS10700 ^@ http://purl.uniprot.org/uniprot/F0RSX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell inner membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05360 ^@ http://purl.uniprot.org/uniprot/F0RYP8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS06575 ^@ http://purl.uniprot.org/uniprot/F0RYY1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/158189:SPIBUDDY_RS05075 ^@ http://purl.uniprot.org/uniprot/F0RVB1 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/158189:SPIBUDDY_RS12935 ^@ http://purl.uniprot.org/uniprot/F0RTE0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenine deaminase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11410 ^@ http://purl.uniprot.org/uniprot/F0RTY7 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/158189:SPIBUDDY_RS02010 ^@ http://purl.uniprot.org/uniprot/F0RXW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14470 ^@ http://purl.uniprot.org/uniprot/F0RS68 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/158189:SPIBUDDY_RS06080 ^@ http://purl.uniprot.org/uniprot/F0RVN4 ^@ Function|||Similarity ^@ Belongs to the band 7/mec-2 family. HflC subfamily.|||HflC and HflK could regulate a protease. http://togogenome.org/gene/158189:SPIBUDDY_RS11160 ^@ http://purl.uniprot.org/uniprot/F0RSW3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/158189:SPIBUDDY_RS11520 ^@ http://purl.uniprot.org/uniprot/F0RSH4 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/158189:SPIBUDDY_RS01315 ^@ http://purl.uniprot.org/uniprot/F0RXQ1 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05155 ^@ http://purl.uniprot.org/uniprot/F0RYK6 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09010 ^@ http://purl.uniprot.org/uniprot/F0RWG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05745 ^@ http://purl.uniprot.org/uniprot/F0RVH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM86 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14340 ^@ http://purl.uniprot.org/uniprot/F0RS44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS09640 ^@ http://purl.uniprot.org/uniprot/F0RWT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS13730 ^@ http://purl.uniprot.org/uniprot/F0RSB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02435 ^@ http://purl.uniprot.org/uniprot/F0RUF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09760 ^@ http://purl.uniprot.org/uniprot/F0RWW2 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS03290 ^@ http://purl.uniprot.org/uniprot/F0RUQ6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/158189:SPIBUDDY_RS06230 ^@ http://purl.uniprot.org/uniprot/F0RYS0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/158189:SPIBUDDY_RS01170 ^@ http://purl.uniprot.org/uniprot/F0RXM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08660 ^@ http://purl.uniprot.org/uniprot/F0RZH7 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS11215 ^@ http://purl.uniprot.org/uniprot/F0RSX6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell inner membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/158189:SPIBUDDY_RS07120 ^@ http://purl.uniprot.org/uniprot/F0RZ14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/158189:SPIBUDDY_RS07320 ^@ http://purl.uniprot.org/uniprot/F0RZ54 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS12775 ^@ http://purl.uniprot.org/uniprot/F0RSD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03120 ^@ http://purl.uniprot.org/uniprot/F0RY27 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS15395 ^@ http://purl.uniprot.org/uniprot/F0RZU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/158189:SPIBUDDY_RS06165 ^@ http://purl.uniprot.org/uniprot/F0RVQ1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/158189:SPIBUDDY_RS05780 ^@ http://purl.uniprot.org/uniprot/F0RVH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10690 ^@ http://purl.uniprot.org/uniprot/F0RSN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10645 ^@ http://purl.uniprot.org/uniprot/F0RTK7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/158189:SPIBUDDY_RS06280 ^@ http://purl.uniprot.org/uniprot/F0RYT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09890 ^@ http://purl.uniprot.org/uniprot/F0RWY6 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/158189:SPIBUDDY_RS09800 ^@ http://purl.uniprot.org/uniprot/F0RWW9 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS14435 ^@ http://purl.uniprot.org/uniprot/F0RS63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS05965 ^@ http://purl.uniprot.org/uniprot/F0RVL1 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS14285 ^@ http://purl.uniprot.org/uniprot/F0RS31 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/158189:SPIBUDDY_RS05570 ^@ http://purl.uniprot.org/uniprot/F0RVD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/158189:SPIBUDDY_RS06735 ^@ http://purl.uniprot.org/uniprot/F0RVT4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03450 ^@ http://purl.uniprot.org/uniprot/F0RUT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/158189:SPIBUDDY_RS07055 ^@ http://purl.uniprot.org/uniprot/F0RZ01 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/158189:SPIBUDDY_RS15610 ^@ http://purl.uniprot.org/uniprot/F0RY29 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS14405 ^@ http://purl.uniprot.org/uniprot/F0RS57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/158189:SPIBUDDY_RS07185 ^@ http://purl.uniprot.org/uniprot/F0RZ27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13960 ^@ http://purl.uniprot.org/uniprot/F0RRW7 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/158189:SPIBUDDY_RS06375 ^@ http://purl.uniprot.org/uniprot/F0RYU2 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/158189:SPIBUDDY_RS09870 ^@ http://purl.uniprot.org/uniprot/F0RWY2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/158189:SPIBUDDY_RS05925 ^@ http://purl.uniprot.org/uniprot/F0RVK3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/158189:SPIBUDDY_RS10790 ^@ http://purl.uniprot.org/uniprot/F0RSZ6 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/158189:SPIBUDDY_RS04760 ^@ http://purl.uniprot.org/uniprot/F0RV50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14025 ^@ http://purl.uniprot.org/uniprot/F0RRY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05865 ^@ http://purl.uniprot.org/uniprot/F0RVJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08810 ^@ http://purl.uniprot.org/uniprot/F0RWC5 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/158189:SPIBUDDY_RS11330 ^@ http://purl.uniprot.org/uniprot/F0RTX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08510 ^@ http://purl.uniprot.org/uniprot/F0RZE7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09910 ^@ http://purl.uniprot.org/uniprot/F0RWZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02895 ^@ http://purl.uniprot.org/uniprot/F0RXY9 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS10555 ^@ http://purl.uniprot.org/uniprot/F0RTJ0 ^@ Cofactor ^@ Binds 2 Mg(2+) ions per monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS09860 ^@ http://purl.uniprot.org/uniprot/F0RWY0 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/158189:SPIBUDDY_RS08475 ^@ http://purl.uniprot.org/uniprot/F0RZE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS15785 ^@ http://purl.uniprot.org/uniprot/F0RSU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS14420 ^@ http://purl.uniprot.org/uniprot/F0RS60 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/158189:SPIBUDDY_RS09820 ^@ http://purl.uniprot.org/uniprot/F0RWX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS06760 ^@ http://purl.uniprot.org/uniprot/F0RVT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS14335 ^@ http://purl.uniprot.org/uniprot/F0RS43 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/158189:SPIBUDDY_RS09075 ^@ http://purl.uniprot.org/uniprot/F0RWH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS04215 ^@ http://purl.uniprot.org/uniprot/F0RV16 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS15725 ^@ http://purl.uniprot.org/uniprot/F0RWY1 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/158189:SPIBUDDY_RS15335 ^@ http://purl.uniprot.org/uniprot/F0RZT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS02135 ^@ http://purl.uniprot.org/uniprot/F0RUA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08385 ^@ http://purl.uniprot.org/uniprot/F0RWB6 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS06010 ^@ http://purl.uniprot.org/uniprot/F0RVM0 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS05040 ^@ http://purl.uniprot.org/uniprot/F0RVA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02290 ^@ http://purl.uniprot.org/uniprot/F0RUD0 ^@ Similarity ^@ Belongs to the four-carbon acid sugar kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14820 ^@ http://purl.uniprot.org/uniprot/F0RTN6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/158189:SPIBUDDY_RS08005 ^@ http://purl.uniprot.org/uniprot/F0RZB5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS13395 ^@ http://purl.uniprot.org/uniprot/F0RTB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14290 ^@ http://purl.uniprot.org/uniprot/F0RS33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/158189:SPIBUDDY_RS15050 ^@ http://purl.uniprot.org/uniprot/F0RZM8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10020 ^@ http://purl.uniprot.org/uniprot/F0RZW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03610 ^@ http://purl.uniprot.org/uniprot/F0RUW9 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS11220 ^@ http://purl.uniprot.org/uniprot/F0RSX7 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/158189:SPIBUDDY_RS08405 ^@ http://purl.uniprot.org/uniprot/F0RWC0 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07040 ^@ http://purl.uniprot.org/uniprot/F0RYZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS07355 ^@ http://purl.uniprot.org/uniprot/F0RVY2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspG family.|||Binds 1 [4Fe-4S] cluster.|||Converts 2C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-2,4cPP) into 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS00980 ^@ http://purl.uniprot.org/uniprot/F0RXI7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13705 ^@ http://purl.uniprot.org/uniprot/F0RSB2 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS09625 ^@ http://purl.uniprot.org/uniprot/F0RWT6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02955 ^@ http://purl.uniprot.org/uniprot/F0RY01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00690 ^@ http://purl.uniprot.org/uniprot/F0RXD0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS15105 ^@ http://purl.uniprot.org/uniprot/F0RZN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07980 ^@ http://purl.uniprot.org/uniprot/F0RZA9 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS10050 ^@ http://purl.uniprot.org/uniprot/F0RTQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS01940 ^@ http://purl.uniprot.org/uniprot/F0RXU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS05725 ^@ http://purl.uniprot.org/uniprot/F0RVG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00115 ^@ http://purl.uniprot.org/uniprot/F0RX19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06460 ^@ http://purl.uniprot.org/uniprot/F0RYV9 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/158189:SPIBUDDY_RS04315 ^@ http://purl.uniprot.org/uniprot/F0RV36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06400 ^@ http://purl.uniprot.org/uniprot/F0RYU7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/158189:SPIBUDDY_RS14235 ^@ http://purl.uniprot.org/uniprot/F0RS21 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/158189:SPIBUDDY_RS13830 ^@ http://purl.uniprot.org/uniprot/F0RRU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14090 ^@ http://purl.uniprot.org/uniprot/F0RRZ2 ^@ Function|||Similarity ^@ Belongs to the UxaE family.|||Catalyzes the epimerization of D-tagaturonate (D-TagA) to D-fructuronate (D-FruA). http://togogenome.org/gene/158189:SPIBUDDY_RS10265 ^@ http://purl.uniprot.org/uniprot/F0RTS7 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS10950 ^@ http://purl.uniprot.org/uniprot/F0RSS4 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/158189:SPIBUDDY_RS13045 ^@ http://purl.uniprot.org/uniprot/F0RT91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10320 ^@ http://purl.uniprot.org/uniprot/F0RTT8 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS12305 ^@ http://purl.uniprot.org/uniprot/F0RRJ3 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/158189:SPIBUDDY_RS12440 ^@ http://purl.uniprot.org/uniprot/F0RRL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01930 ^@ http://purl.uniprot.org/uniprot/F0RXU6 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/158189:SPIBUDDY_RS07530 ^@ http://purl.uniprot.org/uniprot/F0RW16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04800 ^@ http://purl.uniprot.org/uniprot/F0RV58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS07460 ^@ http://purl.uniprot.org/uniprot/F0RW03 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/158189:SPIBUDDY_RS05340 ^@ http://purl.uniprot.org/uniprot/F0RYP4 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04055 ^@ http://purl.uniprot.org/uniprot/F0RUY4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/158189:SPIBUDDY_RS03950 ^@ http://purl.uniprot.org/uniprot/F0RYB6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS00615 ^@ http://purl.uniprot.org/uniprot/F0RXB6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/158189:SPIBUDDY_RS14220 ^@ http://purl.uniprot.org/uniprot/F0RS18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/158189:SPIBUDDY_RS07135 ^@ http://purl.uniprot.org/uniprot/F0RZ17 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. http://togogenome.org/gene/158189:SPIBUDDY_RS10375 ^@ http://purl.uniprot.org/uniprot/F0RU04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02680 ^@ http://purl.uniprot.org/uniprot/F0RUK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02765 ^@ http://purl.uniprot.org/uniprot/F0RUM6 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/158189:SPIBUDDY_RS14910 ^@ http://purl.uniprot.org/uniprot/F0RTQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11585 ^@ http://purl.uniprot.org/uniprot/F0RSI6 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/158189:SPIBUDDY_RS15110 ^@ http://purl.uniprot.org/uniprot/F0RZP0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Molecular chaperone. Has ATPase activity. http://togogenome.org/gene/158189:SPIBUDDY_RS00150 ^@ http://purl.uniprot.org/uniprot/F0RX26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/158189:SPIBUDDY_RS07195 ^@ http://purl.uniprot.org/uniprot/F0RZ29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/158189:SPIBUDDY_RS08125 ^@ http://purl.uniprot.org/uniprot/F0RW63 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/158189:SPIBUDDY_RS01220 ^@ http://purl.uniprot.org/uniprot/F0RXN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04740 ^@ http://purl.uniprot.org/uniprot/F0RV46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. FeoB GTPase (TC 9.A.8) family.|||Cell inner membrane|||Membrane|||Probable transporter of a GTP-driven Fe(2+) uptake system. http://togogenome.org/gene/158189:SPIBUDDY_RS10505 ^@ http://purl.uniprot.org/uniprot/F0RZZ0 ^@ Similarity ^@ Belongs to the UMP kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11155 ^@ http://purl.uniprot.org/uniprot/F0RSW2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/158189:SPIBUDDY_RS12290 ^@ http://purl.uniprot.org/uniprot/F0RRJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08540 ^@ http://purl.uniprot.org/uniprot/F0RZF3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13940 ^@ http://purl.uniprot.org/uniprot/F0RRW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02380 ^@ http://purl.uniprot.org/uniprot/F0RUE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08085 ^@ http://purl.uniprot.org/uniprot/F0RW55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09920 ^@ http://purl.uniprot.org/uniprot/F0RWZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS04185 ^@ http://purl.uniprot.org/uniprot/F0RV10 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/158189:SPIBUDDY_RS02755 ^@ http://purl.uniprot.org/uniprot/F0RUM4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00610 ^@ http://purl.uniprot.org/uniprot/F0RXB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS04570 ^@ http://purl.uniprot.org/uniprot/F0RYG3 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02865 ^@ http://purl.uniprot.org/uniprot/F0RXY3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS10730 ^@ http://purl.uniprot.org/uniprot/F0RSY4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/158189:SPIBUDDY_RS07380 ^@ http://purl.uniprot.org/uniprot/F0RVY7 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS05905 ^@ http://purl.uniprot.org/uniprot/F0RVJ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS09895 ^@ http://purl.uniprot.org/uniprot/F0RWY7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/158189:SPIBUDDY_RS09660 ^@ http://purl.uniprot.org/uniprot/F0RWU3 ^@ Similarity ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS08455 ^@ http://purl.uniprot.org/uniprot/F0RZD6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/158189:SPIBUDDY_RS10765 ^@ http://purl.uniprot.org/uniprot/F0RSZ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10150 ^@ http://purl.uniprot.org/uniprot/F0RTU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15005 ^@ http://purl.uniprot.org/uniprot/F0RZL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS04170 ^@ http://purl.uniprot.org/uniprot/F0RV07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/158189:SPIBUDDY_RS12340 ^@ http://purl.uniprot.org/uniprot/F0RRS0 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/158189:SPIBUDDY_RS04590 ^@ http://purl.uniprot.org/uniprot/F0RYG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01085 ^@ http://purl.uniprot.org/uniprot/F0RXK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0394 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02360 ^@ http://purl.uniprot.org/uniprot/F0RUE4 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/158189:SPIBUDDY_RS12860 ^@ http://purl.uniprot.org/uniprot/F0RSF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Homotetramer.|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/158189:SPIBUDDY_RS02600 ^@ http://purl.uniprot.org/uniprot/F0RUJ3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/158189:SPIBUDDY_RS00215 ^@ http://purl.uniprot.org/uniprot/F0RX38 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00170 ^@ http://purl.uniprot.org/uniprot/F0RX30 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/158189:SPIBUDDY_RS11580 ^@ http://purl.uniprot.org/uniprot/F0RSK2 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04815 ^@ http://purl.uniprot.org/uniprot/F0RV61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/158189:SPIBUDDY_RS04810 ^@ http://purl.uniprot.org/uniprot/F0RV60 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/158189:SPIBUDDY_RS11310 ^@ http://purl.uniprot.org/uniprot/F0RTH1 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10770 ^@ http://purl.uniprot.org/uniprot/F0RSZ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS05785 ^@ http://purl.uniprot.org/uniprot/F0RVH8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15270 ^@ http://purl.uniprot.org/uniprot/F0RZS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00315 ^@ http://purl.uniprot.org/uniprot/F0RX58 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12990 ^@ http://purl.uniprot.org/uniprot/F0RT75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07515 ^@ http://purl.uniprot.org/uniprot/F0RW13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08035 ^@ http://purl.uniprot.org/uniprot/F0RZC1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/158189:SPIBUDDY_RS13000 ^@ http://purl.uniprot.org/uniprot/F0RT77 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/158189:SPIBUDDY_RS05675 ^@ http://purl.uniprot.org/uniprot/F0RVF7 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/158189:SPIBUDDY_RS14190 ^@ http://purl.uniprot.org/uniprot/F0RS12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12925 ^@ http://purl.uniprot.org/uniprot/F0RTD8 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04825 ^@ http://purl.uniprot.org/uniprot/F0RV63 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS15020 ^@ http://purl.uniprot.org/uniprot/F0RZM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14390 ^@ http://purl.uniprot.org/uniprot/F0RS54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS10635 ^@ http://purl.uniprot.org/uniprot/F0RTK5 ^@ Function ^@ The glycine cleavage system catalyzes the degradation of glycine. The P protein binds the alpha-amino group of glycine through its pyridoxal phosphate cofactor; CO(2) is released and the remaining methylamine moiety is then transferred to the lipoamide cofactor of the H protein. http://togogenome.org/gene/158189:SPIBUDDY_RS02625 ^@ http://purl.uniprot.org/uniprot/F0RUJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04040 ^@ http://purl.uniprot.org/uniprot/F0RUY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS01215 ^@ http://purl.uniprot.org/uniprot/F0RXN3 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A lyase-type mechanism (elimination/hydration) is suggested for the cleavage of the lactyl ether bond of MurNAc 6-phosphate, with the formation of an alpha,beta-unsaturated aldehyde intermediate with (E)-stereochemistry, followed by the syn addition of water to give product.|||Belongs to the GCKR-like family. MurNAc-6-P etherase subfamily.|||Homodimer.|||Specifically catalyzes the cleavage of the D-lactyl ether substituent of MurNAc 6-phosphate, producing GlcNAc 6-phosphate and D-lactate. http://togogenome.org/gene/158189:SPIBUDDY_RS03920 ^@ http://purl.uniprot.org/uniprot/F0RYB0 ^@ Similarity ^@ Belongs to the sigma-54 factor family. http://togogenome.org/gene/158189:SPIBUDDY_RS09130 ^@ http://purl.uniprot.org/uniprot/F0RWI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS05235 ^@ http://purl.uniprot.org/uniprot/F0RYM2 ^@ Similarity ^@ Belongs to the N-acylglucosamine 2-epimerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14855 ^@ http://purl.uniprot.org/uniprot/F0RTP3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13540 ^@ http://purl.uniprot.org/uniprot/F0RT44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10465 ^@ http://purl.uniprot.org/uniprot/F0RZY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00945 ^@ http://purl.uniprot.org/uniprot/F0RXI0 ^@ Similarity ^@ Belongs to the UxaA family. http://togogenome.org/gene/158189:SPIBUDDY_RS07370 ^@ http://purl.uniprot.org/uniprot/F0RVY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11355 ^@ http://purl.uniprot.org/uniprot/F0RTX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the rhamnose isomerase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the interconversion of L-rhamnose and L-rhamnulose.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS01705 ^@ http://purl.uniprot.org/uniprot/F0RU92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02590 ^@ http://purl.uniprot.org/uniprot/F0RUJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06845 ^@ http://purl.uniprot.org/uniprot/F0RVV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/158189:SPIBUDDY_RS10190 ^@ http://purl.uniprot.org/uniprot/F0RTV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the etk/wzc family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06550 ^@ http://purl.uniprot.org/uniprot/F0RYX7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the KduI family.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of 5-dehydro-4-deoxy-D-glucuronate to 3-deoxy-D-glycero-2,5-hexodiulosonate. http://togogenome.org/gene/158189:SPIBUDDY_RS14365 ^@ http://purl.uniprot.org/uniprot/F0RS49 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/158189:SPIBUDDY_RS13850 ^@ http://purl.uniprot.org/uniprot/F0RRU5 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/158189:SPIBUDDY_RS08795 ^@ http://purl.uniprot.org/uniprot/F0RZK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15775 ^@ http://purl.uniprot.org/uniprot/F0RSS1 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS08355 ^@ http://purl.uniprot.org/uniprot/F0RWB0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS01895 ^@ http://purl.uniprot.org/uniprot/F0RXT9 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/158189:SPIBUDDY_RS05055 ^@ http://purl.uniprot.org/uniprot/F0RVA9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/158189:SPIBUDDY_RS07285 ^@ http://purl.uniprot.org/uniprot/F0RZ47 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/158189:SPIBUDDY_RS10130 ^@ http://purl.uniprot.org/uniprot/F0RTS5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/158189:SPIBUDDY_RS10590 ^@ http://purl.uniprot.org/uniprot/F0RTJ7 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/158189:SPIBUDDY_RS09655 ^@ http://purl.uniprot.org/uniprot/F0RWU2 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/158189:SPIBUDDY_RS05560 ^@ http://purl.uniprot.org/uniprot/F0RVD3 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/158189:SPIBUDDY_RS08300 ^@ http://purl.uniprot.org/uniprot/F0RW99 ^@ Similarity ^@ Belongs to the four-carbon acid sugar kinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS11070 ^@ http://purl.uniprot.org/uniprot/F0RSU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/158189:SPIBUDDY_RS10800 ^@ http://purl.uniprot.org/uniprot/F0RSZ8 ^@ Similarity ^@ In the N-terminal section; belongs to the zinc metallo-hydrolase group 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS04125 ^@ http://purl.uniprot.org/uniprot/F0RUZ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HCP family.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 hybrid [4Fe-2O-2S] cluster.|||Catalyzes the reduction of hydroxylamine to form NH(3) and H(2)O.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS06655 ^@ http://purl.uniprot.org/uniprot/F0RVR8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/158189:SPIBUDDY_RS11545 ^@ http://purl.uniprot.org/uniprot/F0RSH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS04455 ^@ http://purl.uniprot.org/uniprot/F0RYE1 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS09650 ^@ http://purl.uniprot.org/uniprot/F0RWU1 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS05450 ^@ http://purl.uniprot.org/uniprot/F0RVB6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/158189:SPIBUDDY_RS11475 ^@ http://purl.uniprot.org/uniprot/F0RSG5 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/158189:SPIBUDDY_RS06530 ^@ http://purl.uniprot.org/uniprot/F0RYX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/158189:SPIBUDDY_RS10030 ^@ http://purl.uniprot.org/uniprot/F0RZW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/158189:SPIBUDDY_RS08470 ^@ http://purl.uniprot.org/uniprot/F0RZD9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS03335 ^@ http://purl.uniprot.org/uniprot/F0RUR5 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS05395 ^@ http://purl.uniprot.org/uniprot/F0RYQ5 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14280 ^@ http://purl.uniprot.org/uniprot/F0RS30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/158189:SPIBUDDY_RS13425 ^@ http://purl.uniprot.org/uniprot/F0RT21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04160 ^@ http://purl.uniprot.org/uniprot/F0RV05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10545 ^@ http://purl.uniprot.org/uniprot/F0RTI8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/158189:SPIBUDDY_RS01040 ^@ http://purl.uniprot.org/uniprot/F0RXJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14275 ^@ http://purl.uniprot.org/uniprot/F0RS29 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/158189:SPIBUDDY_RS07630 ^@ http://purl.uniprot.org/uniprot/F0RW35 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/158189:SPIBUDDY_RS02770 ^@ http://purl.uniprot.org/uniprot/F0RUM7 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/158189:SPIBUDDY_RS09190 ^@ http://purl.uniprot.org/uniprot/F0RWK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09615 ^@ http://purl.uniprot.org/uniprot/F0RWT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS15180 ^@ http://purl.uniprot.org/uniprot/F0RZQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04370 ^@ http://purl.uniprot.org/uniprot/F0RYC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07755 ^@ http://purl.uniprot.org/uniprot/F0RZ65 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03215 ^@ http://purl.uniprot.org/uniprot/F0RY45 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS02205 ^@ http://purl.uniprot.org/uniprot/F0RUB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS08120 ^@ http://purl.uniprot.org/uniprot/F0RW62 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/158189:SPIBUDDY_RS15435 ^@ http://purl.uniprot.org/uniprot/F0RZU8 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS02330 ^@ http://purl.uniprot.org/uniprot/F0RUD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TER reductase family.|||Involved in the fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to a coenzyme A (CoA).|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS02425 ^@ http://purl.uniprot.org/uniprot/F0RUF7 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00395 ^@ http://purl.uniprot.org/uniprot/F0RX74 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/158189:SPIBUDDY_RS05525 ^@ http://purl.uniprot.org/uniprot/F0RVC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02040 ^@ http://purl.uniprot.org/uniprot/F0RXW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS11305 ^@ http://purl.uniprot.org/uniprot/F0RTH0 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/158189:SPIBUDDY_RS10330 ^@ http://purl.uniprot.org/uniprot/F0RTU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14510 ^@ http://purl.uniprot.org/uniprot/F0RS77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS08360 ^@ http://purl.uniprot.org/uniprot/F0RWB1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/158189:SPIBUDDY_RS14380 ^@ http://purl.uniprot.org/uniprot/F0RS52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS12525 ^@ http://purl.uniprot.org/uniprot/F0RRN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Forms a 24-polypeptide structural core with octahedral symmetry.|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). It contains multiple copies of three enzymatic components: pyruvate dehydrogenase (E1), dihydrolipoamide acetyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/158189:SPIBUDDY_RS03025 ^@ http://purl.uniprot.org/uniprot/F0RY11 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS03715 ^@ http://purl.uniprot.org/uniprot/F0RY69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04555 ^@ http://purl.uniprot.org/uniprot/F0RYF9 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/158189:SPIBUDDY_RS06870 ^@ http://purl.uniprot.org/uniprot/F0RVW1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/158189:SPIBUDDY_RS08425 ^@ http://purl.uniprot.org/uniprot/F0RZC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell inner membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/158189:SPIBUDDY_RS13900 ^@ http://purl.uniprot.org/uniprot/F0RRV5 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/158189:SPIBUDDY_RS04140 ^@ http://purl.uniprot.org/uniprot/F0RV01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS05000 ^@ http://purl.uniprot.org/uniprot/F0RV98 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ApbE family.|||Cell inner membrane|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/158189:SPIBUDDY_RS06155 ^@ http://purl.uniprot.org/uniprot/F0RVP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/158189:SPIBUDDY_RS04155 ^@ http://purl.uniprot.org/uniprot/F0RV04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12520 ^@ http://purl.uniprot.org/uniprot/F0RRN0 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/158189:SPIBUDDY_RS06640 ^@ http://purl.uniprot.org/uniprot/F0RVR5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/158189:SPIBUDDY_RS04545 ^@ http://purl.uniprot.org/uniprot/F0RYF7 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/158189:SPIBUDDY_RS14675 ^@ http://purl.uniprot.org/uniprot/F0RSA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/158189:SPIBUDDY_RS15350 ^@ http://purl.uniprot.org/uniprot/F0RZT7 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/158189:SPIBUDDY_RS11610 ^@ http://purl.uniprot.org/uniprot/F0RSJ1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/158189:SPIBUDDY_RS03975 ^@ http://purl.uniprot.org/uniprot/F0RYC0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS09015 ^@ http://purl.uniprot.org/uniprot/F0RWG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS13790 ^@ http://purl.uniprot.org/uniprot/F0RRT3 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/158189:SPIBUDDY_RS12310 ^@ http://purl.uniprot.org/uniprot/F0RRJ4 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/158189:SPIBUDDY_RS02805 ^@ http://purl.uniprot.org/uniprot/F0RUN4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS14560 ^@ http://purl.uniprot.org/uniprot/F0RS83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03815 ^@ http://purl.uniprot.org/uniprot/F0RY89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS15700 ^@ http://purl.uniprot.org/uniprot/F0RWD5 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/158189:SPIBUDDY_RS10230 ^@ http://purl.uniprot.org/uniprot/F0RTW4 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/158189:SPIBUDDY_RS03480 ^@ http://purl.uniprot.org/uniprot/F0RUU3 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/158189:SPIBUDDY_RS04015 ^@ http://purl.uniprot.org/uniprot/F0RUX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03075 ^@ http://purl.uniprot.org/uniprot/F0RY21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS12650 ^@ http://purl.uniprot.org/uniprot/F0RRQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14795 ^@ http://purl.uniprot.org/uniprot/F0RTN1 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/158189:SPIBUDDY_RS04890 ^@ http://purl.uniprot.org/uniprot/F0RV76 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/158189:SPIBUDDY_RS11415 ^@ http://purl.uniprot.org/uniprot/F0RTY8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/158189:SPIBUDDY_RS13160 ^@ http://purl.uniprot.org/uniprot/F0RTC9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09815 ^@ http://purl.uniprot.org/uniprot/F0RWX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/158189:SPIBUDDY_RS04765 ^@ http://purl.uniprot.org/uniprot/F0RV51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14300 ^@ http://purl.uniprot.org/uniprot/F0RS35 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/158189:SPIBUDDY_RS00280 ^@ http://purl.uniprot.org/uniprot/F0RX51 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS07570 ^@ http://purl.uniprot.org/uniprot/F0RW24 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/158189:SPIBUDDY_RS03240 ^@ http://purl.uniprot.org/uniprot/F0RUP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06015 ^@ http://purl.uniprot.org/uniprot/F0RVM1 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06580 ^@ http://purl.uniprot.org/uniprot/F0RYY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/158189:SPIBUDDY_RS05185 ^@ http://purl.uniprot.org/uniprot/F0RYL2 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/158189:SPIBUDDY_RS05335 ^@ http://purl.uniprot.org/uniprot/F0RYP3 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/158189:SPIBUDDY_RS10655 ^@ http://purl.uniprot.org/uniprot/F0RTK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS00565 ^@ http://purl.uniprot.org/uniprot/F0RXA7 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS05580 ^@ http://purl.uniprot.org/uniprot/F0RVD7 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/158189:SPIBUDDY_RS03460 ^@ http://purl.uniprot.org/uniprot/F0RUU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS02845 ^@ http://purl.uniprot.org/uniprot/F0RUP1 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/158189:SPIBUDDY_RS09775 ^@ http://purl.uniprot.org/uniprot/F0RWW5 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/158189:SPIBUDDY_RS15605 ^@ http://purl.uniprot.org/uniprot/F0RY28 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/158189:SPIBUDDY_RS01225 ^@ http://purl.uniprot.org/uniprot/F0RXN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS14000 ^@ http://purl.uniprot.org/uniprot/F0RRX5 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/158189:SPIBUDDY_RS03590 ^@ http://purl.uniprot.org/uniprot/F0RUW5 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/158189:SPIBUDDY_RS01800 ^@ http://purl.uniprot.org/uniprot/F0RXS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS02025 ^@ http://purl.uniprot.org/uniprot/F0RXW3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CutC family.|||Cytoplasm|||Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case. http://togogenome.org/gene/158189:SPIBUDDY_RS15405 ^@ http://purl.uniprot.org/uniprot/F0RZU3 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/158189:SPIBUDDY_RS15895 ^@ http://purl.uniprot.org/uniprot/F0RT47 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS05355 ^@ http://purl.uniprot.org/uniprot/F0RYP7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS06470 ^@ http://purl.uniprot.org/uniprot/F0RYW1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A double ring-shaped homohexamer of HslV is capped on each side by a ring-shaped HslU homohexamer. The assembly of the HslU/HslV complex is dependent on binding of ATP.|||Allosterically activated by HslU binding.|||Belongs to the peptidase T1B family. HslV subfamily.|||Cytoplasm|||Protease subunit of a proteasome-like degradation complex believed to be a general protein degrading machinery. http://togogenome.org/gene/158189:SPIBUDDY_RS06695 ^@ http://purl.uniprot.org/uniprot/F0RVS6 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04805 ^@ http://purl.uniprot.org/uniprot/F0RV59 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/158189:SPIBUDDY_RS14110 ^@ http://purl.uniprot.org/uniprot/F0RRZ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/158189:SPIBUDDY_RS08715 ^@ http://purl.uniprot.org/uniprot/F0RZI7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/158189:SPIBUDDY_RS07310 ^@ http://purl.uniprot.org/uniprot/F0RZ52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/158189:SPIBUDDY_RS00485 ^@ http://purl.uniprot.org/uniprot/F0RX92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06060 ^@ http://purl.uniprot.org/uniprot/F0RVN0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/158189:SPIBUDDY_RS10070 ^@ http://purl.uniprot.org/uniprot/F0RTR3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/158189:SPIBUDDY_RS05475 ^@ http://purl.uniprot.org/uniprot/F0RVC1 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/158189:SPIBUDDY_RS06160 ^@ http://purl.uniprot.org/uniprot/F0RVQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/158189:SPIBUDDY_RS01160 ^@ http://purl.uniprot.org/uniprot/F0RXM2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/158189:SPIBUDDY_RS06660 ^@ http://purl.uniprot.org/uniprot/F0RVR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/158189:SPIBUDDY_RS11505 ^@ http://purl.uniprot.org/uniprot/F0RSH1 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/158189:SPIBUDDY_RS14505 ^@ http://purl.uniprot.org/uniprot/F0RS75 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/158189:SPIBUDDY_RS11650 ^@ http://purl.uniprot.org/uniprot/F0RSJ9 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS14315 ^@ http://purl.uniprot.org/uniprot/F0RS38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/158189:SPIBUDDY_RS08175 ^@ http://purl.uniprot.org/uniprot/F0RW74 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS04430 ^@ http://purl.uniprot.org/uniprot/F0RYD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS03560 ^@ http://purl.uniprot.org/uniprot/F0RUV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10540 ^@ http://purl.uniprot.org/uniprot/F0RTI7 ^@ Function|||Similarity ^@ Belongs to the vsr family.|||May nick specific sequences that contain T:G mispairs resulting from m5C-deamination. http://togogenome.org/gene/158189:SPIBUDDY_RS07260 ^@ http://purl.uniprot.org/uniprot/F0RZ42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS06680 ^@ http://purl.uniprot.org/uniprot/F0RVS3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/158189:SPIBUDDY_RS08980 ^@ http://purl.uniprot.org/uniprot/F0RWF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/158189:SPIBUDDY_RS10075 ^@ http://purl.uniprot.org/uniprot/F0RTR4 ^@ Function|||Similarity ^@ Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a repressor.|||Belongs to the biotin--protein ligase family. http://togogenome.org/gene/158189:SPIBUDDY_RS04180 ^@ http://purl.uniprot.org/uniprot/F0RV09 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS10245 ^@ http://purl.uniprot.org/uniprot/F0RTW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GcvT family.|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/158189:SPIBUDDY_RS14615 ^@ http://purl.uniprot.org/uniprot/F0RS89 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/158189:SPIBUDDY_RS03510 ^@ http://purl.uniprot.org/uniprot/F0RUU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane