http://togogenome.org/gene/187101:VC03_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00245 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9E4 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/187101:VC03_RS02400 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTR2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/187101:VC03_RS05200 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAF2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. MTA/SAH deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of 5-methylthioadenosine and S-adenosyl-L-homocysteine into 5-methylthioinosine and S-inosyl-L-homocysteine, respectively. Is also able to deaminate adenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS02060 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial diacylglycerol kinase family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05980 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBW7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/187101:VC03_RS02005 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS03055 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBH7 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/187101:VC03_RS03250 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04755 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU19 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/187101:VC03_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/187101:VC03_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC66 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/187101:VC03_RS01325 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 3 family.|||Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS06055 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCA8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/187101:VC03_RS01930 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB76 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/187101:VC03_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC68 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/187101:VC03_RS00740 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA73 ^@ Similarity ^@ Belongs to the peptidase C69 family. http://togogenome.org/gene/187101:VC03_RS02545 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS02150 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA22 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Catalyzes the phosphorylation of D-xylulose to D-xylulose 5-phosphate. http://togogenome.org/gene/187101:VC03_RS04680 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAN2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/187101:VC03_RS00555 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS01625 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9L6 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/187101:VC03_RS05970 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCM8 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/187101:VC03_RS01365 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUE8 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/187101:VC03_RS04400 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS02100 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBA2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/187101:VC03_RS02360 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9T1 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/187101:VC03_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9T6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/187101:VC03_RS00705 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS05720 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD24 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/187101:VC03_RS05740 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAK7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/187101:VC03_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA28 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/187101:VC03_RS03635 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBM8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA13 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/187101:VC03_RS04480 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/187101:VC03_RS00430 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA38 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per trimer. http://togogenome.org/gene/187101:VC03_RS00900 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9L3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01610 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUG3 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01780 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS01635 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUG5 ^@ Function|||Similarity ^@ Belongs to the carbohydrate kinase PfkB family.|||Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate. http://togogenome.org/gene/187101:VC03_RS02030 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS02980 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/187101:VC03_RS01370 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/187101:VC03_RS00645 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC37 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/187101:VC03_RS05845 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU82 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/187101:VC03_RS06365 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/187101:VC03_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS00585 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTG8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/187101:VC03_RS06885 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/187101:VC03_RS02550 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUM5 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/187101:VC03_RS01200 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUD7 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/187101:VC03_RS00110 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTE4 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04315 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/187101:VC03_RS05535 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAY7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/187101:VC03_RS01405 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBN2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS03670 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/187101:VC03_RS04210 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ2 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01940 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS00970 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS02285 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTQ4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Activation of pyruvate formate-lyase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC3 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS06440 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUC2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. http://togogenome.org/gene/187101:VC03_RS02460 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/187101:VC03_RS01295 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAD5 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/187101:VC03_RS06890 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS04665 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/187101:VC03_RS04365 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUW5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS06295 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV94 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/187101:VC03_RS03870 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAF9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcAL family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of elongator tRNA(Met), using acetate and ATP as substrates. First activates an acetate ion to form acetyladenylate (Ac-AMP) and then transfers the acetyl group to tRNA to form ac(4)C34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04875 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV14 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/187101:VC03_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A0E3UVA4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS05075 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS00015 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/187101:VC03_RS01505 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL5 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/187101:VC03_RS03895 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA44 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB19 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/187101:VC03_RS06470 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/187101:VC03_RS00925 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9F4 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/187101:VC03_RS02130 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP4 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/187101:VC03_RS03320 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCC4 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/187101:VC03_RS01360 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00535 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/187101:VC03_RS04455 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/187101:VC03_RS04940 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/187101:VC03_RS06205 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAQ0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS01670 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS01520 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9S1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class B bacterial acid phosphatase family.|||Homotetramer.|||Periplasm http://togogenome.org/gene/187101:VC03_RS00985 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAA1 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/187101:VC03_RS03830 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/187101:VC03_RS03185 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/187101:VC03_RS05925 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAM2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/187101:VC03_RS06030 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB41 ^@ Similarity ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/187101:VC03_RS00165 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTE6 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/187101:VC03_RS00735 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9D4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/187101:VC03_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/187101:VC03_RS03880 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBQ0 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/187101:VC03_RS06285 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC97 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/187101:VC03_RS04640 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUX9 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/187101:VC03_RS00995 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/187101:VC03_RS05940 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBW3 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/187101:VC03_RS05005 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU32 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/187101:VC03_RS01245 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9P3 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily.|||Catalyzes the removal of elemental sulfur and selenium atoms from L-cysteine, L-cystine, L-selenocysteine, and L-selenocystine to produce L-alanine. http://togogenome.org/gene/187101:VC03_RS00710 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS02490 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTR8 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/187101:VC03_RS04415 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCK7 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS02010 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/187101:VC03_RS03605 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/187101:VC03_RS01730 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS02470 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/187101:VC03_RS05040 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS02145 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xylose isomerase family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/187101:VC03_RS03505 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/187101:VC03_RS04995 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCR6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS03780 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTX6 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/187101:VC03_RS06355 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV98 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/187101:VC03_RS06130 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUS1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DnaX/STICHEL family.|||DNA polymerase III contains a core (composed of alpha, epsilon and theta chains) that associates with a tau subunit. This core dimerizes to form the POLIII' complex. PolIII' associates with the gamma complex (composed of gamma, delta, delta', psi and chi chains) and with the beta chain to form the complete DNA polymerase III complex.|||DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/187101:VC03_RS01355 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS01440 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBN9 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/187101:VC03_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 1 family.|||Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/187101:VC03_RS00580 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/187101:VC03_RS03820 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/187101:VC03_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCD6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/187101:VC03_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAE7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/187101:VC03_RS04035 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU9 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/187101:VC03_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV57 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS03555 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/187101:VC03_RS06485 ^@ http://purl.uniprot.org/uniprot/A0A0E3UVA6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/187101:VC03_RS04580 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA96 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/187101:VC03_RS01000 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04885 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCQ5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/187101:VC03_RS02540 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell membrane|||Probably interacts with PlsX. http://togogenome.org/gene/187101:VC03_RS02200 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00575 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS05750 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/187101:VC03_RS05420 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/187101:VC03_RS03375 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCC8 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/187101:VC03_RS06320 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV96 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/187101:VC03_RS03570 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/187101:VC03_RS05390 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBN6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/187101:VC03_RS01765 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUR6 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/187101:VC03_RS00525 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU91 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS05045 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC00 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT6 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/187101:VC03_RS04320 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAJ4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS00435 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9G5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/187101:VC03_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9D0 ^@ Similarity ^@ Belongs to the phosphopentomutase family. http://togogenome.org/gene/187101:VC03_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05160 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV06 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS04695 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU17 ^@ Similarity ^@ Belongs to the KHG/KDPG aldolase family. http://togogenome.org/gene/187101:VC03_RS00950 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/187101:VC03_RS05700 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/187101:VC03_RS04060 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01170 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBK1 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/187101:VC03_RS00590 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/187101:VC03_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS02475 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/187101:VC03_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB07 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/187101:VC03_RS04180 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA64 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS06255 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBZ7 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/187101:VC03_RS02350 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCP9 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/187101:VC03_RS00685 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS05220 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU40 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/187101:VC03_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU48 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS01840 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01235 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9I3 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/187101:VC03_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/187101:VC03_RS04190 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/187101:VC03_RS06160 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the branched chain amino acid transporter family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC91 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/187101:VC03_RS06290 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCD2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/187101:VC03_RS02465 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTR6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/187101:VC03_RS00660 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUA1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS01665 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS02480 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/187101:VC03_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9N6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/187101:VC03_RS00280 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9G3 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/187101:VC03_RS01275 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9I7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/187101:VC03_RS00680 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9D2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/187101:VC03_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/187101:VC03_RS06350 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAR6 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/187101:VC03_RS02680 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA70 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04905 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/187101:VC03_RS02015 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBZ8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/187101:VC03_RS03960 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTY2 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/187101:VC03_RS01395 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIB subfamily.|||Cell inner membrane|||Mediates magnesium influx to the cytosol. http://togogenome.org/gene/187101:VC03_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV44 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/187101:VC03_RS03590 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS06445 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00495 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/187101:VC03_RS01605 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBR0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/187101:VC03_RS05710 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS04405 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS05600 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV37 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/187101:VC03_RS06170 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/187101:VC03_RS01950 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS02450 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/187101:VC03_RS06150 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCB8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/187101:VC03_RS04445 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBC2 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/187101:VC03_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/187101:VC03_RS05365 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC35 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/187101:VC03_RS05830 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS05485 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCL5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/187101:VC03_RS02240 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA30 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/187101:VC03_RS05070 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/187101:VC03_RS01615 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/187101:VC03_RS01465 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/187101:VC03_RS01280 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCF6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS03280 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBJ7 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/187101:VC03_RS03845 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Membrane http://togogenome.org/gene/187101:VC03_RS06330 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZDA3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01925 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBY2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/187101:VC03_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBL0 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/187101:VC03_RS01475 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL4 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/187101:VC03_RS03645 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/187101:VC03_RS00550 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/187101:VC03_RS01870 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS01230 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK4 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/187101:VC03_RS04465 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/187101:VC03_RS00520 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9H5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/187101:VC03_RS05870 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS06480 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB84 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/187101:VC03_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/187101:VC03_RS00785 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA79 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/187101:VC03_RS05955 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS03315 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTV9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/187101:VC03_RS01640 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL9 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS05065 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAD8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/187101:VC03_RS01760 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUH5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01305 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBL9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/187101:VC03_RS01070 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAX1 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/187101:VC03_RS06370 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB75 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/187101:VC03_RS06740 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAS9 ^@ Function|||Similarity ^@ Belongs to the NrdI family.|||Probably involved in ribonucleotide reductase function. http://togogenome.org/gene/187101:VC03_RS04985 ^@ http://purl.uniprot.org/uniprot/A0A0E3UVD0 ^@ Caution|||Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/187101:VC03_RS06450 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZDB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05585 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAZ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS02535 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA56 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/187101:VC03_RS06280 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD98 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/187101:VC03_RS03305 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS02290 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAU8 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/187101:VC03_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV86 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/187101:VC03_RS00545 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9B8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/187101:VC03_RS05820 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/187101:VC03_RS06270 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS01600 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9S7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/187101:VC03_RS04395 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUW8 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS00405 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAS8 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/187101:VC03_RS05275 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC26 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/187101:VC03_RS04815 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU23 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/187101:VC03_RS00255 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTE9 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS05795 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU77 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/187101:VC03_RS06145 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD79 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/187101:VC03_RS01195 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC4 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/187101:VC03_RS00600 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/187101:VC03_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/187101:VC03_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAW9 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/187101:VC03_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/187101:VC03_RS02045 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP5 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/187101:VC03_RS01040 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS05105 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAE2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04810 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUZ0 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/187101:VC03_RS00960 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/187101:VC03_RS02575 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZDE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/187101:VC03_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/187101:VC03_RS03345 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTW0 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/187101:VC03_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTY9 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCJ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04625 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA98 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/187101:VC03_RS03690 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/187101:VC03_RS02205 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00790 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9K4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/187101:VC03_RS06190 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD85 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/187101:VC03_RS03905 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAG4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Belongs to the AAA ATPase family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/187101:VC03_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAB3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04585 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBD7 ^@ Function|||Similarity ^@ A P subtype restriction enzyme that recognizes the double-stranded unmethylated sequence 5'-GATC-3'.|||Belongs to the DpnII type II restriction endonuclease family. http://togogenome.org/gene/187101:VC03_RS04825 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP6 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/187101:VC03_RS05620 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04370 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS04250 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV7 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/187101:VC03_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS02165 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC12 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/187101:VC03_RS00700 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA67 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK2 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/187101:VC03_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS02585 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUM6 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/187101:VC03_RS01885 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS02635 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/187101:VC03_RS04290 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA72 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/187101:VC03_RS02185 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/187101:VC03_RS06385 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/187101:VC03_RS03040 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTU6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/187101:VC03_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A0E3UVC2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/187101:VC03_RS05890 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS02455 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9U1 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/187101:VC03_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS04420 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUW9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/187101:VC03_RS05525 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/187101:VC03_RS00610 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTH0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS00780 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9D9 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/187101:VC03_RS03835 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCX3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL31 family. http://togogenome.org/gene/187101:VC03_RS03170 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUR5 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/187101:VC03_RS04450 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS04085 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV1 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/187101:VC03_RS05255 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/187101:VC03_RS03165 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAA9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/187101:VC03_RS05115 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04740 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCN7 ^@ Function|||Similarity ^@ Belongs to the mannonate dehydratase family.|||Catalyzes the dehydration of D-mannonate. http://togogenome.org/gene/187101:VC03_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/187101:VC03_RS03885 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/187101:VC03_RS00500 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/187101:VC03_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04070 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCI2 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/187101:VC03_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB31 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBR9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/187101:VC03_RS06475 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/187101:VC03_RS05000 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUZ9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/187101:VC03_RS06305 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAR1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/187101:VC03_RS01125 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUD1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/187101:VC03_RS00895 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTI7 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/187101:VC03_RS05835 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/187101:VC03_RS01300 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9P7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/187101:VC03_RS03290 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTV8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/187101:VC03_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04310 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS03685 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/187101:VC03_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU38 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/187101:VC03_RS02260 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9W0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/187101:VC03_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arginine deiminase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS03910 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine. http://togogenome.org/gene/187101:VC03_RS04440 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA83 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01035 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTJ6 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/187101:VC03_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU28 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/187101:VC03_RS06315 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB70 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/187101:VC03_RS05945 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB30 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/187101:VC03_RS01590 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTL7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/187101:VC03_RS05695 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAK3 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/187101:VC03_RS04510 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/187101:VC03_RS00530 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTG6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/187101:VC03_RS06380 ^@ http://purl.uniprot.org/uniprot/A0A0E3UVA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/187101:VC03_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUD3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/187101:VC03_RS00570 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9I1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/187101:VC03_RS04910 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS01470 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/187101:VC03_RS06400 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Cell membrane|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/187101:VC03_RS05705 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV50 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/187101:VC03_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/187101:VC03_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUC6 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/187101:VC03_RS04980 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS03800 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00620 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBD5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/187101:VC03_RS02155 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUJ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/187101:VC03_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV76 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CutC family.|||Cytoplasm|||Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case. http://togogenome.org/gene/187101:VC03_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBS3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04790 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU21 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/187101:VC03_RS00880 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9E9 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/187101:VC03_RS01375 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05770 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD29 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS01980 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05730 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV52 ^@ Similarity ^@ Belongs to the RNA polymerase subunit omega family. http://togogenome.org/gene/187101:VC03_RS01825 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTM7 ^@ Caution|||Function|||Similarity ^@ Belongs to the NrdR family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/187101:VC03_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAD6 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/187101:VC03_RS02445 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC44 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/187101:VC03_RS06135 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB53 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS03955 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZD10 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/187101:VC03_RS03115 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05715 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB05 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/187101:VC03_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTG1 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. http://togogenome.org/gene/187101:VC03_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05400 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCX9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/187101:VC03_RS00515 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA47 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCK4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/187101:VC03_RS01135 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBJ4 ^@ Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily. http://togogenome.org/gene/187101:VC03_RS03365 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01775 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBT7 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/187101:VC03_RS05465 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAH9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/187101:VC03_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAC9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01130 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTJ9 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/187101:VC03_RS02640 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/187101:VC03_RS03585 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/187101:VC03_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTX0 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/187101:VC03_RS03530 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBM0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/187101:VC03_RS05175 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCU8 ^@ Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/187101:VC03_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS05405 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV22 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/187101:VC03_RS03580 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/187101:VC03_RS00215 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04970 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUZ8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/187101:VC03_RS01785 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUH7 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/187101:VC03_RS05725 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC73 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/187101:VC03_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTW8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/187101:VC03_RS00240 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA11 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/187101:VC03_RS01445 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUF4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/187101:VC03_RS05370 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS03485 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/187101:VC03_RS05500 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCZ2 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per trimer. http://togogenome.org/gene/187101:VC03_RS04105 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04715 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAA8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/187101:VC03_RS01855 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAK2 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/187101:VC03_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB37 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/187101:VC03_RS03900 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB72 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/187101:VC03_RS00615 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9I6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/187101:VC03_RS01320 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK7 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/187101:VC03_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBP2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase H family.|||Binds 2 metal ions per subunit. Manganese or magnesium.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/187101:VC03_RS06195 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCC3 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/187101:VC03_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUK7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS04345 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCD5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/187101:VC03_RS05650 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAK1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/187101:VC03_RS05020 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBI7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS04990 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAR0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS01180 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK1 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04975 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU31 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/187101:VC03_RS04745 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBX4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family. http://togogenome.org/gene/187101:VC03_RS00945 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTJ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/187101:VC03_RS02630 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA65 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/187101:VC03_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUM3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/187101:VC03_RS05960 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS04870 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUZ4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M42 family.|||Binds 2 divalent metal cations per subunit. http://togogenome.org/gene/187101:VC03_RS01420 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUF2 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/187101:VC03_RS05315 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCW6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AmiS/UreI family.|||Membrane http://togogenome.org/gene/187101:VC03_RS03110 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9Z0 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/187101:VC03_RS02505 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/187101:VC03_RS00690 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS06375 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZDA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/187101:VC03_RS04945 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCR1 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/187101:VC03_RS06165 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.|||Catalyzes the sodium-dependent transport of glutamate.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS01770 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9U8 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/187101:VC03_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/187101:VC03_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBF7 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/187101:VC03_RS01735 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS05545 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C15 family.|||Cytoplasm|||Homotetramer.|||Removes 5-oxoproline from various penultimate amino acid residues except L-proline. http://togogenome.org/gene/187101:VC03_RS04205 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/187101:VC03_RS04485 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS00980 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTJ2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS00540 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAU0 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/187101:VC03_RS01380 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAE5 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/187101:VC03_RS06395 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAS0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/187101:VC03_RS03985 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUU6 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/187101:VC03_RS05235 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/187101:VC03_RS04275 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. TrmL subfamily.|||Could methylate the ribose at the nucleotide 34 wobble position in tRNA.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04025 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/187101:VC03_RS01185 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAX7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit. http://togogenome.org/gene/187101:VC03_RS00595 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9C3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/187101:VC03_RS05250 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBL7 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/187101:VC03_RS03065 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUQ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/187101:VC03_RS03990 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/187101:VC03_RS04000 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA51 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/187101:VC03_RS00800 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTI1 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/187101:VC03_RS01160 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAB9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/187101:VC03_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBM3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/187101:VC03_RS06125 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUA0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/187101:VC03_RS02375 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTR0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS05270 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/187101:VC03_RS03980 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS01875 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB94 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/187101:VC03_RS05080 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUF1 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/187101:VC03_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBU1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/187101:VC03_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9S2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05615 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS04355 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBB5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS04930 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Membrane http://togogenome.org/gene/187101:VC03_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV68 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/187101:VC03_RS03675 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCE8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S16 family.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/187101:VC03_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/187101:VC03_RS04280 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTZ4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/187101:VC03_RS01945 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS01790 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTM6 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/187101:VC03_RS01655 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB22 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/187101:VC03_RS02230 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS05085 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV02 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/187101:VC03_RS02210 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTP9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/187101:VC03_RS04145 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUV4 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/187101:VC03_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/187101:VC03_RS01910 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTN2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/187101:VC03_RS05875 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU84 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/187101:VC03_RS01620 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB16 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/187101:VC03_RS01220 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS00725 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/187101:VC03_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTN6 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/187101:VC03_RS05965 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC96 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/187101:VC03_RS00190 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/187101:VC03_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAX5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS03175 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/187101:VC03_RS01455 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZB02 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS06360 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUB8 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/187101:VC03_RS01290 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK6 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/187101:VC03_RS04795 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCP4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/187101:VC03_RS05455 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS02555 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta sliding clamp family.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS00730 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAV1 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/187101:VC03_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS01155 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GroES chaperonin family.|||Heptamer of 7 subunits arranged in a ring.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/187101:VC03_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAE0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS00560 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA53 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/187101:VC03_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCJ3 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/187101:VC03_RS05775 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC77 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/187101:VC03_RS05210 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/187101:VC03_RS01585 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUG1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/187101:VC03_RS04730 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/187101:VC03_RS00135 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autotransporter-2 (AT-2) (TC 1.B.40) family.|||Cell surface http://togogenome.org/gene/187101:VC03_RS05520 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU54 ^@ Similarity ^@ Belongs to the DNA polymerase type-A family. http://togogenome.org/gene/187101:VC03_RS01500 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUF8 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/187101:VC03_RS00920 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTI8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/187101:VC03_RS00875 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAV9 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/187101:VC03_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/187101:VC03_RS01140 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAX3 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/187101:VC03_RS05385 ^@ http://purl.uniprot.org/uniprot/A0A0E3UU46 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/187101:VC03_RS06260 ^@ http://purl.uniprot.org/uniprot/A0A0E3UV92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/187101:VC03_RS01565 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBQ3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/187101:VC03_RS03440 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZA17 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 1 family. Bacterial/plant glycogen synthase subfamily.|||Synthesizes alpha-1,4-glucan chains using ADP-glucose. http://togogenome.org/gene/187101:VC03_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A0E3UUB3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/187101:VC03_RS03385 ^@ http://purl.uniprot.org/uniprot/A0A0E3UTW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/187101:VC03_RS03060 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9Y6 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/187101:VC03_RS01485 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBP7 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/187101:VC03_RS05745 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZBT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/187101:VC03_RS03925 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZCG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/187101:VC03_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZAP1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/187101:VC03_RS06310 ^@ http://purl.uniprot.org/uniprot/A0A0E3ZC03 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/187101:VC03_RS01750 ^@ http://purl.uniprot.org/uniprot/A0A0E3Z9M5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision.