http://togogenome.org/gene/2174846:DDW44_RS07695 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17495 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS22710 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY22 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS10215 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS49 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the CofD family.|||Catalyzes the transfer of the phosphoenolpyruvate moiety from enoylpyruvoyl-2-diphospho-5'-guanosine (EPPG) to 7,8-didemethyl-8-hydroxy-5-deazariboflavin (FO) with the formation of dehydro coenzyme F420-0 and GMP.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS11740 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSV2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS08310 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQW6 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/2174846:DDW44_RS15800 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/2174846:DDW44_RS22395 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/2174846:DDW44_RS26755 ^@ http://purl.uniprot.org/uniprot/A0A2S1T000 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNR0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AP endonuclease 2 family.|||Binds 3 Zn(2+) ions.|||Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate. http://togogenome.org/gene/2174846:DDW44_RS04005 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNT0 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/2174846:DDW44_RS08360 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NDK family.|||Cytoplasm|||Homotetramer.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/2174846:DDW44_RS07545 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS06075 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPT3 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/2174846:DDW44_RS14160 ^@ http://purl.uniprot.org/uniprot/A0A2S1STS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS22950 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY55 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/2174846:DDW44_RS04050 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNU3 ^@ Caution|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 2 heme c groups covalently per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit. http://togogenome.org/gene/2174846:DDW44_RS11225 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSA5 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/2174846:DDW44_RS03645 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNN2 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/2174846:DDW44_RS14805 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS21290 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXA0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS11495 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSF6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS16390 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUU3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/2174846:DDW44_RS24390 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYT0 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2174846:DDW44_RS11230 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSB3 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/2174846:DDW44_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNX3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/2174846:DDW44_RS08800 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR44 ^@ Function|||Similarity ^@ Belongs to the RecD family. RecD-like subfamily.|||DNA-dependent ATPase and ATP-dependent 5'-3' DNA helicase. Has no activity on blunt DNA or DNA with 3'-overhangs, requires at least 10 bases of 5'-ssDNA for helicase activity. http://togogenome.org/gene/2174846:DDW44_RS09770 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRK9 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/2174846:DDW44_RS17165 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/2174846:DDW44_RS19020 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW55 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/2174846:DDW44_RS00640 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM07 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/2174846:DDW44_RS03060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SND3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pseudouridine-5'-phosphate glycosidase family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the reversible cleavage of pseudouridine 5'-phosphate (PsiMP) to ribose 5-phosphate and uracil. Functions biologically in the cleavage direction, as part of a pseudouridine degradation pathway.|||Homotrimer. http://togogenome.org/gene/2174846:DDW44_RS17355 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVB2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS08255 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQV9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/2174846:DDW44_RS16655 ^@ http://purl.uniprot.org/uniprot/A0A2S1T361 ^@ Similarity ^@ Belongs to the DNA polymerase type-A family. http://togogenome.org/gene/2174846:DDW44_RS15045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/2174846:DDW44_RS17155 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV89 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/2174846:DDW44_RS12100 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. Tam family.|||Catalyzes the S-adenosylmethionine monomethyl esterification of trans-aconitate.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS25765 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Catalyzes the hydrolysis of 5-hydroxyisourate (HIU) to 2-oxo-4-hydroxy-4-carboxy-5-ureidoimidazoline (OHCU).|||Homotetramer. http://togogenome.org/gene/2174846:DDW44_RS08000 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17990 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS09535 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS22705 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXZ9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS07470 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQI0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/2174846:DDW44_RS09520 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/2174846:DDW44_RS24745 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS30100 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS27625 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0K6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS25675 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZG9 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/2174846:DDW44_RS17470 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD8 ^@ Similarity ^@ Belongs to the complex I 24 kDa subunit family. http://togogenome.org/gene/2174846:DDW44_RS16845 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 49 kDa subunit family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS12325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSY1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/2174846:DDW44_RS19815 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWJ7 ^@ Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family. http://togogenome.org/gene/2174846:DDW44_RS21485 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02955 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNB3 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/2174846:DDW44_RS23620 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYF1 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/2174846:DDW44_RS08635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR65 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/2174846:DDW44_RS18115 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW23 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/2174846:DDW44_RS23070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS17370 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnE family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the addition of the adenosyl radical to the double bond of 3-[(1-carboxyvinyl)oxy]benzoate, leading to aminodeoxyfutalosine (AFL), a key intermediate in the formation of menaquinone (MK, vitamin K2) from chorismate. http://togogenome.org/gene/2174846:DDW44_RS06975 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ71 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/2174846:DDW44_RS31170 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2G8 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/2174846:DDW44_RS07330 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS22955 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY52 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/2174846:DDW44_RS07870 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQN7 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/2174846:DDW44_RS11375 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSG0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2174846:DDW44_RS00970 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM95 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/2174846:DDW44_RS15530 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS16825 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS12755 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST16 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2174846:DDW44_RS16995 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV58 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DisA family.|||Has also diadenylate cyclase activity, catalyzing the condensation of 2 ATP molecules into cyclic di-AMP (c-di-AMP). c-di-AMP acts as a signaling molecule that couples DNA integrity with progression of sporulation. The rise in c-di-AMP level generated by DisA while scanning the chromosome, operates as a positive signal that advances sporulation; upon encountering a lesion, the DisA focus arrests at the damaged site and halts c-di-AMP synthesis.|||Homooctamer.|||Participates in a DNA-damage check-point that is active prior to asymmetric division when DNA is damaged. DisA forms globular foci that rapidly scan along the chromosomes during sporulation, searching for lesions. When a lesion is present, DisA pauses at the lesion site. This triggers a cellular response that culminates in a temporary block in sporulation initiation. http://togogenome.org/gene/2174846:DDW44_RS13315 ^@ http://purl.uniprot.org/uniprot/A0A2S1T304 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/2174846:DDW44_RS02710 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN50 ^@ Function|||Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes reversively the conversion of L-aspartate beta-semialdehyde (ASA) to L-2,4-diaminobutyrate (DABA) by transamination with L-glutamate. http://togogenome.org/gene/2174846:DDW44_RS13400 ^@ http://purl.uniprot.org/uniprot/A0A2S1STE9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DtxR/MntR family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS11510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSI3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2174846:DDW44_RS24765 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PAPS reductase family. CysD subfamily.|||Heterodimer composed of CysD, the smaller subunit, and CysN.|||With CysN forms the ATP sulfurylase (ATPS) that catalyzes the adenylation of sulfate producing adenosine 5'-phosphosulfate (APS) and diphosphate, the first enzymatic step in sulfur assimilation pathway. APS synthesis involves the formation of a high-energy phosphoric-sulfuric acid anhydride bond driven by GTP hydrolysis by CysN coupled to ATP hydrolysis by CysD. http://togogenome.org/gene/2174846:DDW44_RS08940 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR83 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/2174846:DDW44_RS03355 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNH8 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS21445 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXE3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS18535 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVW4 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/2174846:DDW44_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS09025 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS27805 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0N4 ^@ Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family. http://togogenome.org/gene/2174846:DDW44_RS18130 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVR4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/2174846:DDW44_RS30095 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS22155 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS31080 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2A2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS28985 ^@ http://purl.uniprot.org/uniprot/A0A2S1T145 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS23175 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY96 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/2174846:DDW44_RS02060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMS9 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/2174846:DDW44_RS22170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY76 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2174846:DDW44_RS02970 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/2174846:DDW44_RS19600 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWT7 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/2174846:DDW44_RS21525 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3E0 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/2174846:DDW44_RS11405 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSG7 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/2174846:DDW44_RS24415 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZ95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS07600 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS15230 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU97 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS18210 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVS2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS09665 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRJ7 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/2174846:DDW44_RS12060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SST1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/2174846:DDW44_RS20025 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatB family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatC, TatB is part of a receptor directly interacting with Tat signal peptides. TatB may form an oligomeric binding site that transiently accommodates folded Tat precursor proteins before their translocation.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2174846:DDW44_RS18105 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS04360 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNY6 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/2174846:DDW44_RS13505 ^@ http://purl.uniprot.org/uniprot/A0A2S1STG7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS20625 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS04295 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP10 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Oligomer of 12 subunits arranged in the form of two hexagons. http://togogenome.org/gene/2174846:DDW44_RS20955 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX35 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS02790 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN41 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.|||Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.|||Cytoplasm|||Homotrimer. http://togogenome.org/gene/2174846:DDW44_RS13415 ^@ http://purl.uniprot.org/uniprot/A0A2S1STF6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the pyridoxamine 5'-phosphate oxidase family.|||Binds 1 FMN per subunit.|||Catalyzes the oxidation of either pyridoxine 5'-phosphate (PNP) or pyridoxamine 5'-phosphate (PMP) into pyridoxal 5'-phosphate (PLP).|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS11440 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/2174846:DDW44_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ53 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/2174846:DDW44_RS21905 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXL8 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS17500 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS20390 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWT9 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/2174846:DDW44_RS18035 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/2174846:DDW44_RS20035 ^@ http://purl.uniprot.org/uniprot/A0A2S1T378 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/2174846:DDW44_RS19645 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWG9 ^@ Similarity ^@ Belongs to the nitroreductase family. HadB/RutE subfamily. http://togogenome.org/gene/2174846:DDW44_RS04960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS11320 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSE4 ^@ Similarity ^@ Belongs to the barstar family. http://togogenome.org/gene/2174846:DDW44_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPT7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS17965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/2174846:DDW44_RS23660 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS08060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQR6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/2174846:DDW44_RS22760 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/2174846:DDW44_RS07375 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQH2 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/2174846:DDW44_RS05135 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS06595 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ15 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/2174846:DDW44_RS08355 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/2174846:DDW44_RS18000 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS26325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZS2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-A subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer).|||Cell membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. http://togogenome.org/gene/2174846:DDW44_RS02445 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMX7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS20590 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWV8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMG8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/2174846:DDW44_RS17615 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVF7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS16710 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVC6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS10205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRU9 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS11625 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSJ3 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/2174846:DDW44_RS13770 ^@ http://purl.uniprot.org/uniprot/A0A2S1STN1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS12285 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/2174846:DDW44_RS11620 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSM7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Catalyzes the conjugation of the 1'-hydroxyl group of D-myo-inositol-3-phosphate (also named L-myo-inositol-1-phosphate) with a lipid tail of cytidine diphosphate diacylglycerol (CDP-DAG), forming phosphatidylinositol phosphate (PIP) and CMP. PIP is a precursor of phosphatidylinositol (PI) which is an essential lipid required for cell wall formation.|||Cell membrane|||Contains a di-nuclear catalytic Mg(2+) center.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS15190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS05435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPH0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/2174846:DDW44_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell membrane|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/2174846:DDW44_RS15815 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/2174846:DDW44_RS09755 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRV4 ^@ Similarity ^@ Belongs to the UPF0301 (AlgH) family. http://togogenome.org/gene/2174846:DDW44_RS25410 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZF4 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS20080 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS22005 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXQ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/2174846:DDW44_RS09030 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR87 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2174846:DDW44_RS17425 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ2 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/2174846:DDW44_RS11195 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbxX/CfxQ family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS07965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M4 family.|||Extracellular zinc metalloprotease.|||Secreted http://togogenome.org/gene/2174846:DDW44_RS10425 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRX6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease beta subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/2174846:DDW44_RS21175 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX76 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/2174846:DDW44_RS00735 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM31 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/2174846:DDW44_RS27005 ^@ http://purl.uniprot.org/uniprot/A0A2S1T041 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS20375 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWY0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS06140 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS14165 ^@ http://purl.uniprot.org/uniprot/A0A2S1STS9 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/2174846:DDW44_RS15520 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUE5 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/2174846:DDW44_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNI5 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/2174846:DDW44_RS03475 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNK7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRA-CH family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolysis of the adenine ring of phosphoribosyl-AMP.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS02815 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN61 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/2174846:DDW44_RS27855 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0L2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/2174846:DDW44_RS04055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS12870 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS10165 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRS9 ^@ Cofactor|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2174846:DDW44_RS02190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2174846:DDW44_RS16435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUV8 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/2174846:DDW44_RS21065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/2174846:DDW44_RS31455 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2G7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/2174846:DDW44_RS10155 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRT9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/2174846:DDW44_RS23270 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/2174846:DDW44_RS10815 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS30 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS18585 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS12470 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST02 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Although this enzyme belongs to the family of MTA phosphorylases based on sequence homology, it lacks several conserved amino acids in the substrate binding pocket that confer specificity towards MTA.|||Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Purine nucleoside phosphorylase involved in purine salvage. http://togogenome.org/gene/2174846:DDW44_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ46 ^@ Similarity ^@ Belongs to the CsoR family. http://togogenome.org/gene/2174846:DDW44_RS17065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS02960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gluconeogenesis factor family.|||Cytoplasm|||Required for morphogenesis under gluconeogenic growth conditions. http://togogenome.org/gene/2174846:DDW44_RS14420 ^@ http://purl.uniprot.org/uniprot/A0A2S1STU9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/2174846:DDW44_RS22370 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXR3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/2174846:DDW44_RS08275 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQX0 ^@ Similarity ^@ Belongs to the UDP-N-acetylglucosamine 2-epimerase family. http://togogenome.org/gene/2174846:DDW44_RS14195 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU40 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/2174846:DDW44_RS22085 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/2174846:DDW44_RS07720 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS07930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQN3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS28890 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS08065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQS8 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/2174846:DDW44_RS20435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX78 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/2174846:DDW44_RS09950 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRP8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/2174846:DDW44_RS28010 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3G0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2174846:DDW44_RS05170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPD5 ^@ Function|||Similarity ^@ Belongs to the PstS family.|||Involved in the system for phosphate transport across the cytoplasmic membrane. http://togogenome.org/gene/2174846:DDW44_RS27655 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0K4 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/2174846:DDW44_RS27015 ^@ http://purl.uniprot.org/uniprot/A0A2S1T048 ^@ Cofactor|||Similarity ^@ Belongs to the fatty acid desaturase type 2 family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/2174846:DDW44_RS27180 ^@ http://purl.uniprot.org/uniprot/A0A2S1T070 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IPP isomerase type 1 family.|||Binds 1 Mg(2+) ion per subunit. The magnesium ion binds only when substrate is bound.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP).|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS27910 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0Q4 ^@ Similarity ^@ Belongs to the AfsR/DnrI/RedD regulatory family. http://togogenome.org/gene/2174846:DDW44_RS14930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU65 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/2174846:DDW44_RS16680 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUZ7 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS23965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYL9 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/2174846:DDW44_RS18505 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW95 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/2174846:DDW44_RS18935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17475 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVF3 ^@ Function|||Similarity ^@ Belongs to the complex I 51 kDa subunit family.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. http://togogenome.org/gene/2174846:DDW44_RS10175 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRY4 ^@ Similarity ^@ Belongs to the UPF0434 family. http://togogenome.org/gene/2174846:DDW44_RS10210 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRU7 ^@ Similarity ^@ Belongs to the cysteine dioxygenase family. http://togogenome.org/gene/2174846:DDW44_RS11220 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS16795 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV10 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/2174846:DDW44_RS17505 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS11280 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSB9 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/2174846:DDW44_RS14845 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SsgA family.|||Cell septum http://togogenome.org/gene/2174846:DDW44_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS29040 ^@ http://purl.uniprot.org/uniprot/A0A2S1T143 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS16745 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/2174846:DDW44_RS07435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQG5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Member of the two-component regulatory system NreB/NreC involved in the control of dissimilatory nitrate/nitrite reduction in response to oxygen. NreB functions as a direct oxygen sensor histidine kinase which is autophosphorylated, in the absence of oxygen, probably at the conserved histidine residue, and transfers its phosphate group probably to a conserved aspartate residue of NreC. NreB/NreC activates the expression of the nitrate (narGHJI) and nitrite (nir) reductase operons, as well as the putative nitrate transporter gene narT. http://togogenome.org/gene/2174846:DDW44_RS10445 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRZ5 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/2174846:DDW44_RS15170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUA9 ^@ Similarity ^@ Belongs to the thioesterase family. http://togogenome.org/gene/2174846:DDW44_RS23185 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3S2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methylthiotransferase family. MiaB subfamily.|||Binds 2 [4Fe-4S] clusters. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-(dimethylallyl)adenosine (i(6)A), leading to the formation of 2-methylthio-N6-(dimethylallyl)adenosine (ms(2)i(6)A) at position 37 in tRNAs that read codons beginning with uridine.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS08375 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQY3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/2174846:DDW44_RS01715 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily.|||Cytoplasm|||Facilitates the functional incorporation of the urease nickel metallocenter. This process requires GTP hydrolysis, probably effectuated by UreG.|||Homodimer. UreD, UreF and UreG form a complex that acts as a GTP-hydrolysis-dependent molecular chaperone, activating the urease apoprotein by helping to assemble the nickel containing metallocenter of UreC. The UreE protein probably delivers the nickel. http://togogenome.org/gene/2174846:DDW44_RS17640 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVI5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS22400 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS23275 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYA9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/2174846:DDW44_RS02255 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMY3 ^@ Domain|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic ubiquitin-like protein family.|||Is modified by deamidation of its C-terminal glutamine to glutamate by the deamidase Dop, a prerequisite to the subsequent pupylation process.|||Protein modifier that is covalently attached to lysine residues of substrate proteins, thereby targeting them for proteasomal degradation. The tagging system is termed pupylation.|||Strongly interacts with the proteasome-associated ATPase ARC through a hydrophobic interface; the interacting region of Pup lies in its C-terminal half. There is one Pup binding site per ARC hexamer ring.|||The N-terminal unstructured half of Pup provides a signal required to initiate unfolding and degradation by the proteasome but is not needed for pupylation, while the C-terminal helical half of Pup interacts with ARC to target proteins to the proteasome. http://togogenome.org/gene/2174846:DDW44_RS11595 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/2174846:DDW44_RS17635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS29375 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1A5 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS08160 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR25 ^@ Similarity ^@ Belongs to the complex I 51 kDa subunit family. http://togogenome.org/gene/2174846:DDW44_RS09225 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS04290 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS00785 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM85 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/2174846:DDW44_RS03885 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterioferritin family.|||Homooligomer of 24 subunits, arranged as 12 dimers, that are packed together to form an approximately spherical molecule with a central cavity, in which large amounts of iron can be deposited.|||Iron-storage protein, whose ferroxidase center binds Fe(2+) ions, oxidizes them by dioxygen to Fe(3+), and participates in the subsequent Fe(3+) oxide mineral core formation within the central cavity of the protein complex. http://togogenome.org/gene/2174846:DDW44_RS01690 ^@ http://purl.uniprot.org/uniprot/A0A2S1SML6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CobB/CobQ family. GatD subfamily.|||Forms a heterodimer with MurT.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The GatD subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia. The resulting ammonia molecule is channeled to the active site of MurT. http://togogenome.org/gene/2174846:DDW44_RS15055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/2174846:DDW44_RS16770 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS19635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWF1 ^@ Similarity ^@ Belongs to the FBPase class 2 family. http://togogenome.org/gene/2174846:DDW44_RS22205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXN7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/2174846:DDW44_RS23020 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY39 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/2174846:DDW44_RS14565 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU86 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS19475 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS24070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/2174846:DDW44_RS18125 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/2174846:DDW44_RS26700 ^@ http://purl.uniprot.org/uniprot/A0A2S1T024 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS04560 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP65 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/2174846:DDW44_RS18070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/2174846:DDW44_RS21415 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXD0 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/2174846:DDW44_RS19660 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWI7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/2174846:DDW44_RS18565 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW02 ^@ Function|||Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family.|||Catalyzes the reversible oxidation of malate to oxaloacetate. http://togogenome.org/gene/2174846:DDW44_RS08385 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQX1 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2174846:DDW44_RS05525 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPK4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/2174846:DDW44_RS29105 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1N4 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/2174846:DDW44_RS18010 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/2174846:DDW44_RS07400 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS11390 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSD2 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/2174846:DDW44_RS21035 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS26035 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS18530 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVV8 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/2174846:DDW44_RS22315 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXS9 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/2174846:DDW44_RS09645 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SsgA family.|||Cell septum http://togogenome.org/gene/2174846:DDW44_RS20750 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWY7 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS12565 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSZ4 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/2174846:DDW44_RS25490 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3F4 ^@ Cofactor ^@ Can also use Mn(2+) ion. http://togogenome.org/gene/2174846:DDW44_RS03635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNK0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS29490 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1C6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/2174846:DDW44_RS03015 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS07405 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQG8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/2174846:DDW44_RS20965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS16905 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV26 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS17030 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV69 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS18030 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS12415 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSZ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MoaC family.|||Catalyzes the conversion of (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate to cyclic pyranopterin monophosphate (cPMP).|||Homohexamer; trimer of dimers. http://togogenome.org/gene/2174846:DDW44_RS20960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX43 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/2174846:DDW44_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS26540 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZX4 ^@ Similarity ^@ Belongs to the cysteine dioxygenase family. http://togogenome.org/gene/2174846:DDW44_RS21855 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXG8 ^@ Similarity ^@ Belongs to the agmatine deiminase family. http://togogenome.org/gene/2174846:DDW44_RS18725 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW13 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/2174846:DDW44_RS14945 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU53 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/2174846:DDW44_RS08005 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQZ6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/2174846:DDW44_RS03260 ^@ http://purl.uniprot.org/uniprot/A0A2S1SND9 ^@ Similarity ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family. http://togogenome.org/gene/2174846:DDW44_RS21440 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXR9 ^@ Similarity ^@ Belongs to the iron-sulfur dependent L-serine dehydratase family. http://togogenome.org/gene/2174846:DDW44_RS22260 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXP7 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/2174846:DDW44_RS18090 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS04035 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNS4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS02835 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN52 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/2174846:DDW44_RS16765 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/2174846:DDW44_RS22215 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18310 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVU3 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS03700 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/2174846:DDW44_RS17935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVZ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/2174846:DDW44_RS18075 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/2174846:DDW44_RS04205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNW5 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/2174846:DDW44_RS30275 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1T4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/2174846:DDW44_RS22235 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXT8 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/2174846:DDW44_RS11400 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSP4 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS17415 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVC7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MqnC family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Radical SAM enzyme that catalyzes the cyclization of dehypoxanthine futalosine (DHFL) into cyclic dehypoxanthine futalosine (CDHFL), a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/2174846:DDW44_RS02945 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN69 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS26025 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS19570 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWE9 ^@ Function|||Similarity|||Subunit ^@ Antioxidant protein with alkyl hydroperoxidase activity. Required for the reduction of the AhpC active site cysteine residues and for the regeneration of the AhpC enzyme activity.|||Belongs to the AhpD family.|||Homotrimer. http://togogenome.org/gene/2174846:DDW44_RS11870 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSR3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/2174846:DDW44_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMV6 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS21480 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS03640 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DivIVA family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS04045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Cell membrane|||Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02820 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN68 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/2174846:DDW44_RS07505 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQI9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the NADPH-dependent reduction of beta-ketoacyl-ACP substrates to beta-hydroxyacyl-ACP products, the first reductive step in the elongation cycle of fatty acid biosynthesis.|||Homotetramer. http://togogenome.org/gene/2174846:DDW44_RS27010 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aids in the defense against invading fungal pathogens by degrading their cell wall chitosan.|||Belongs to the glycosyl hydrolase 46 family.|||Secreted http://togogenome.org/gene/2174846:DDW44_RS07275 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQC0 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS06190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPV4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS17915 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVL1 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2174846:DDW44_RS07830 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQP5 ^@ Function ^@ Catalyzes the reduction of sulfite to sulfide, a step in the biosynthesis of sulfur-containing amino acids and cofactors. http://togogenome.org/gene/2174846:DDW44_RS27425 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0A9 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS20055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS00955 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM73 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/2174846:DDW44_RS30180 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1W1 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS17930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/2174846:DDW44_RS17510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS01085 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS04990 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPA4 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/2174846:DDW44_RS10535 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRY0 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/2174846:DDW44_RS21560 ^@ http://purl.uniprot.org/uniprot/A0A2S1T391 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/2174846:DDW44_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Membrane|||Subunits I and II form the functional core of the enzyme complex. Electrons originating in cytochrome c are transferred via heme a and Cu(A) to the binuclear center formed by heme a3 and Cu(B). http://togogenome.org/gene/2174846:DDW44_RS10350 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS06085 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPV0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/2174846:DDW44_RS09460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRG9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GroES chaperonin family.|||Heptamer of 7 subunits arranged in a ring.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2174846:DDW44_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ13 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2174846:DDW44_RS19065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW69 ^@ Similarity ^@ Belongs to the adenylyl cyclase class-3 family. http://togogenome.org/gene/2174846:DDW44_RS24455 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYV9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS18005 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/2174846:DDW44_RS11345 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSN7 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/2174846:DDW44_RS26565 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZW7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/2174846:DDW44_RS21740 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXK2 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/2174846:DDW44_RS08395 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/2174846:DDW44_RS11455 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/2174846:DDW44_RS06495 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPZ5 ^@ Caution|||Similarity ^@ Belongs to the nitrobindin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lacks the conserved His residue that binds heme iron in the nitrobindin family. http://togogenome.org/gene/2174846:DDW44_RS19480 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17430 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVF2 ^@ Similarity|||Subunit ^@ Belongs to the glutaminase family.|||Homotetramer. http://togogenome.org/gene/2174846:DDW44_RS12065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSS2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/2174846:DDW44_RS14115 ^@ http://purl.uniprot.org/uniprot/A0A2S1STR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/2174846:DDW44_RS00235 ^@ http://purl.uniprot.org/uniprot/A0A2S1SLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS15595 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUR4 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS00940 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM48 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/2174846:DDW44_RS08445 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQZ5 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/2174846:DDW44_RS18020 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/2174846:DDW44_RS30305 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1Y7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbsD / FucU family. RbsD subfamily.|||Catalyzes the interconversion of beta-pyran and beta-furan forms of D-ribose.|||Cytoplasm|||Homodecamer. http://togogenome.org/gene/2174846:DDW44_RS04070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with subunits I, II and III to form cytochrome c oxidase.|||Belongs to the cytochrome c oxidase bacterial subunit CtaF family.|||Cell membrane|||Membrane|||Part of cytochrome c oxidase, its function is unknown. http://togogenome.org/gene/2174846:DDW44_RS18620 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVY5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2174846:DDW44_RS20230 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWR6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||Nucleus|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS11580 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/2174846:DDW44_RS26545 ^@ http://purl.uniprot.org/uniprot/A0A2S1T003 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS12135 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSR9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS11060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS11335 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSC1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/2174846:DDW44_RS28360 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0R7 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS16675 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUZ5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/2174846:DDW44_RS17945 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2174846:DDW44_RS28365 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0U1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Catalyzes the production of L-lysyl-tRNA(Lys)transfer and the transfer of a lysyl group from L-lysyl-tRNA(Lys) to membrane-bound phosphatidylglycerol (PG), which produces lysylphosphatidylglycerol (LPG), one of the components of the bacterial membrane with a positive net charge. LPG synthesis contributes to the resistance to cationic antimicrobial peptides (CAMPs) and likely protects M.tuberculosis against the CAMPs produced by competiting microorganisms (bacteriocins). In fact, the modification of anionic phosphatidylglycerol with positively charged L-lysine results in repulsion of the peptides.|||Cell membrane|||Cytoplasm|||Homodimer.|||In the C-terminal section; belongs to the class-II aminoacyl-tRNA synthetase family.|||In the N-terminal section; belongs to the LPG synthetase family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS03295 ^@ http://purl.uniprot.org/uniprot/A0A2S1SND7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/2174846:DDW44_RS02195 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/2174846:DDW44_RS19745 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2174846:DDW44_RS12070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/2174846:DDW44_RS10270 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRV2 ^@ Similarity ^@ Belongs to the acyl coenzyme A hydrolase family. http://togogenome.org/gene/2174846:DDW44_RS24890 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZ11 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/2174846:DDW44_RS27755 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0M4 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/2174846:DDW44_RS19195 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW82 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/2174846:DDW44_RS21055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/2174846:DDW44_RS03825 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNQ4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the thiamine-phosphate synthase family.|||Binds 1 Mg(2+) ion per subunit.|||Condenses 4-methyl-5-(beta-hydroxyethyl)thiazole monophosphate (THZ-P) and 2-methyl-4-amino-5-hydroxymethyl pyrimidine pyrophosphate (HMP-PP) to form thiamine monophosphate (TMP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS08510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR11 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS26125 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZQ5 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/2174846:DDW44_RS21180 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX64 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/2174846:DDW44_RS26695 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/2174846:DDW44_RS24675 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZD5 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS29470 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1D8 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2174846:DDW44_RS09605 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRH7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ClpS family.|||Binds to the N-terminal domain of the chaperone ClpA.|||Involved in the modulation of the specificity of the ClpAP-mediated ATP-dependent protein degradation. http://togogenome.org/gene/2174846:DDW44_RS03390 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS10915 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sbp family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS22195 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A probable RNA-binding protein.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS07410 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS13665 ^@ http://purl.uniprot.org/uniprot/A0A2S1STK4 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/2174846:DDW44_RS02225 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMW9 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2174846:DDW44_RS22915 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/2174846:DDW44_RS20990 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX88 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/2174846:DDW44_RS14810 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18025 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/2174846:DDW44_RS17975 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/2174846:DDW44_RS09465 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18320 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW66 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS18925 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW29 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenosine deaminase subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of adenosine and 2-deoxyadenosine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS22280 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS18295 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVR8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/2174846:DDW44_RS24775 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZ17 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PAPS reductase family. CysH subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS14940 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU47 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS06480 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ16 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS24470 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Coproporphyrinogen III oxidase subfamily.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the oxidation of coproporphyrinogen III to coproporphyrin III. http://togogenome.org/gene/2174846:DDW44_RS16980 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVH3 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS18215 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/2174846:DDW44_RS21850 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXK5 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family.|||Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||Carboxylation allows a single lysine to coordinate two nickel ions.|||Cytoplasm|||May form a heterohexamer of 3 UreC (alpha) and 3 UreAB (gamma/beta) subunits. May also form a heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/2174846:DDW44_RS27860 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0P3 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/2174846:DDW44_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN83 ^@ Function|||Similarity ^@ Belongs to the RapZ-like family.|||Displays ATPase and GTPase activities. http://togogenome.org/gene/2174846:DDW44_RS19160 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW92 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/2174846:DDW44_RS17060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS23580 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS28475 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0W1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. EgtD family.|||Catalyzes the SAM-dependent triple methylation of the alpha-amino group of histidine to form hercynine, a step in the biosynthesis pathway of ergothioneine.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS18055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/2174846:DDW44_RS12760 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST23 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS18095 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS17885 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVK6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/2174846:DDW44_RS17335 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS03695 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS14955 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU37 ^@ Similarity ^@ Belongs to the FemABX family. http://togogenome.org/gene/2174846:DDW44_RS08290 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQW3 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. http://togogenome.org/gene/2174846:DDW44_RS23045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS19435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWE5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class II subfamily. http://togogenome.org/gene/2174846:DDW44_RS03615 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNN8 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/2174846:DDW44_RS21635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXF1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/2174846:DDW44_RS21235 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX89 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS03680 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS13120 ^@ http://purl.uniprot.org/uniprot/A0A2S1STA7 ^@ Similarity ^@ Belongs to the F420H(2)-dependent quinone reductase family. http://togogenome.org/gene/2174846:DDW44_RS09365 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRF3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/2174846:DDW44_RS20885 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX26 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/2174846:DDW44_RS13845 ^@ http://purl.uniprot.org/uniprot/A0A2S1STM9 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/2174846:DDW44_RS19975 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWK6 ^@ Similarity ^@ Belongs to the LOG family. http://togogenome.org/gene/2174846:DDW44_RS15715 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18040 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS29170 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1P4 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS19955 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3M7 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2174846:DDW44_RS05685 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS07285 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQF2 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/2174846:DDW44_RS22100 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXM0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2174846:DDW44_RS15590 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUG5 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/2174846:DDW44_RS07865 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQP7 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/2174846:DDW44_RS14400 ^@ http://purl.uniprot.org/uniprot/A0A2S1STV6 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28A subfamily. http://togogenome.org/gene/2174846:DDW44_RS07790 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2Y6 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/2174846:DDW44_RS27825 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0I6 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/2174846:DDW44_RS20635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWX5 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/2174846:DDW44_RS18860 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW43 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/2174846:DDW44_RS09860 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/2174846:DDW44_RS22200 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXN4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/2174846:DDW44_RS18305 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVS6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS13365 ^@ http://purl.uniprot.org/uniprot/A0A2S1STE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protease inhibitor I16 (SSI) family.|||Homodimer.|||Secreted|||Strong inhibitor of bacterial serine proteases such as subtilisin. http://togogenome.org/gene/2174846:DDW44_RS00750 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM45 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS28755 ^@ http://purl.uniprot.org/uniprot/A0A2S1T107 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/2174846:DDW44_RS11140 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSB4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase-binding protein RbpA family.|||Bind 1 Zn(2+) per subunit.|||Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.|||Forms a complex with the RNAP catalytic core and with free principal sigma factors. http://togogenome.org/gene/2174846:DDW44_RS11065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS80 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LamB/PxpA family.|||Catalyzes the cleavage of 5-oxoproline to form L-glutamate coupled to the hydrolysis of ATP to ADP and inorganic phosphate.|||Forms a complex composed of PxpA, PxpB and PxpC. http://togogenome.org/gene/2174846:DDW44_RS15960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUM1 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/2174846:DDW44_RS27385 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0C2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 4L family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS23595 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYW2 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/2174846:DDW44_RS25590 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS01680 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMP2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/2174846:DDW44_RS17600 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 1 family.|||Cell membrane|||Membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. This subunit may bind ubiquinone. http://togogenome.org/gene/2174846:DDW44_RS08105 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR16 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/2174846:DDW44_RS29810 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1I2 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/2174846:DDW44_RS01745 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SsgA family.|||Cell septum http://togogenome.org/gene/2174846:DDW44_RS28485 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0V9 ^@ Function|||Similarity ^@ Belongs to the EgtB family.|||Catalyzes the oxidative sulfurization of hercynine (N-alpha,N-alpha,N-alpha-trimethyl-L-histidine) into hercynyl-gamma-L-glutamyl-L-cysteine sulfoxide, a step in the biosynthesis pathway of ergothioneine. http://togogenome.org/gene/2174846:DDW44_RS21585 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXH2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/2174846:DDW44_RS28820 ^@ http://purl.uniprot.org/uniprot/A0A2S1T104 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gas vesicle protein type A family.|||Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. GvpA type proteins form the essential core of the structure.|||gas vesicle membrane http://togogenome.org/gene/2174846:DDW44_RS18665 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS22190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXU0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/2174846:DDW44_RS26105 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZN3 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2174846:DDW44_RS30110 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1N3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS22290 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/2174846:DDW44_RS19950 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWN9 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2174846:DDW44_RS09865 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Homodimer. Forms a membrane-associated complex with FtsX.|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/2174846:DDW44_RS01450 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMK3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/2174846:DDW44_RS18340 ^@ http://purl.uniprot.org/uniprot/A0A2S1T395 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS04435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS07070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/2174846:DDW44_RS07300 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQF1 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/2174846:DDW44_RS29245 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS24125 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZ38 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/2174846:DDW44_RS28960 ^@ http://purl.uniprot.org/uniprot/A0A2S1T153 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/2174846:DDW44_RS11710 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSM0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS27045 ^@ http://purl.uniprot.org/uniprot/A0A2S1T062 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/2174846:DDW44_RS07975 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS23235 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS08200 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQV0 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/2174846:DDW44_RS23205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY48 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS14745 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS09785 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRL6 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS21500 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS07905 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS22135 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18730 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW48 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/2174846:DDW44_RS30205 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1S4 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/2174846:DDW44_RS17900 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/2174846:DDW44_RS20380 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX65 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS26180 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZN9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/2174846:DDW44_RS17180 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV87 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/2174846:DDW44_RS08335 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS10305 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRT8 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS09850 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/2174846:DDW44_RS15090 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU83 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/2174846:DDW44_RS01700 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMM8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS19470 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWE6 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/2174846:DDW44_RS08935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR80 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS17655 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18120 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVS5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/2174846:DDW44_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPI8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS19515 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWC3 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/2174846:DDW44_RS21645 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXG6 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/2174846:DDW44_RS21170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX91 ^@ Similarity ^@ Belongs to the methylmalonyl-CoA epimerase family. http://togogenome.org/gene/2174846:DDW44_RS01060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM93 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/2174846:DDW44_RS30060 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3K4 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/2174846:DDW44_RS14935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/2174846:DDW44_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNC8 ^@ Function|||Subcellular Location Annotation ^@ Iron-sulfur subunit of the cytochrome bc1 complex, an essential component of the respiratory electron transport chain required for ATP synthesis. The bc1 complex catalyzes the oxidation of menaquinol and the reduction of cytochrome c in the respiratory chain. The bc1 complex operates through a Q-cycle mechanism that couples electron transfer to generation of the proton gradient that drives ATP synthesis.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18280 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/2174846:DDW44_RS21050 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/2174846:DDW44_RS16920 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV36 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS17340 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVA7 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/2174846:DDW44_RS11590 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS20950 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/2174846:DDW44_RS26165 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZT8 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2174846:DDW44_RS22055 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3C7 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/2174846:DDW44_RS03500 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Involved in both the histidine and tryptophan biosynthetic pathways. http://togogenome.org/gene/2174846:DDW44_RS00520 ^@ http://purl.uniprot.org/uniprot/A0A2S1SLZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AmiS/UreI family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS18085 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN8 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/2174846:DDW44_RS18060 ^@ http://purl.uniprot.org/uniprot/A0A2S1T350 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family. Zinc-binding uS14 subfamily.|||Binds 1 zinc ion per subunit.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/2174846:DDW44_RS21350 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXA7 ^@ Similarity|||Subunit ^@ Belongs to the aminoglycoside phosphotransferase family.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS11555 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS16720 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUZ9 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/2174846:DDW44_RS27050 ^@ http://purl.uniprot.org/uniprot/A0A2S1T093 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/2174846:DDW44_RS19550 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWS7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS09045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS03335 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNH9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS26635 ^@ http://purl.uniprot.org/uniprot/A0A2S1T016 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS02045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMU3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/2174846:DDW44_RS07305 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQD4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS13615 ^@ http://purl.uniprot.org/uniprot/A0A2S1STI7 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/2174846:DDW44_RS21870 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXN5 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/2174846:DDW44_RS17960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/2174846:DDW44_RS10430 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRY1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the urease gamma subunit family.|||Cytoplasm|||Heterotrimer of UreA (gamma), UreB (beta) and UreC (alpha) subunits. Three heterotrimers associate to form the active enzyme. http://togogenome.org/gene/2174846:DDW44_RS13765 ^@ http://purl.uniprot.org/uniprot/A0A2S1STW0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cell surface|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.|||capsule|||cell wall http://togogenome.org/gene/2174846:DDW44_RS17970 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS03510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS21570 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXG2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/2174846:DDW44_RS18015 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN2 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/2174846:DDW44_RS27230 ^@ http://purl.uniprot.org/uniprot/A0A2S1T075 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS20485 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWV5 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Allosterically activated by N-acetylglucosamine 6-phosphate (GlcNAc6P).|||Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS22245 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXV0 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/2174846:DDW44_RS27580 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0W2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS23005 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02110 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMR3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS17170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV73 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/2174846:DDW44_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mediates influx of magnesium ions.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS24385 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS18960 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW65 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS21045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/2174846:DDW44_RS18400 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS18330 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVU0 ^@ Similarity ^@ Belongs to the IMPDH/GMPR family. http://togogenome.org/gene/2174846:DDW44_RS18780 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3B7 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS06070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPR9 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/2174846:DDW44_RS08860 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2S4 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/2174846:DDW44_RS08400 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR28 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/2174846:DDW44_RS22075 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXQ7 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/2174846:DDW44_RS06225 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPX0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/2174846:DDW44_RS12785 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST31 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS16690 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUZ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/2174846:DDW44_RS21835 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXL7 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2174846:DDW44_RS07235 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQE9 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/2174846:DDW44_RS08190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQY5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/2174846:DDW44_RS18135 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/2174846:DDW44_RS17920 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/2174846:DDW44_RS03135 ^@ http://purl.uniprot.org/uniprot/A0A2S1SND8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPL6 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/2174846:DDW44_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPG1 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS11875 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSN0 ^@ Similarity ^@ Belongs to the transglycosylase family. Rpf subfamily. http://togogenome.org/gene/2174846:DDW44_RS05725 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS21220 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX90 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS08220 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS21110 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX72 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/2174846:DDW44_RS02230 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMZ1 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the Pup ligase/Pup deamidase family. Pup-conjugating enzyme subfamily.|||Catalyzes the covalent attachment of the prokaryotic ubiquitin-like protein modifier Pup to the proteasomal substrate proteins, thereby targeting them for proteasomal degradation. This tagging system is termed pupylation. The ligation reaction involves the side-chain carboxylate of the C-terminal glutamate of Pup and the side-chain amino group of a substrate lysine.|||The reaction mechanism probably proceeds via the activation of Pup by phosphorylation of its C-terminal glutamate, which is then subject to nucleophilic attack by the substrate lysine, resulting in an isopeptide bond and the release of phosphate as a good leaving group. http://togogenome.org/gene/2174846:DDW44_RS11585 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSH1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/2174846:DDW44_RS12300 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SsgA family.|||Cell septum http://togogenome.org/gene/2174846:DDW44_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/2174846:DDW44_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMV5 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/2174846:DDW44_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN70 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS19205 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW81 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A mycothiol (MSH, N-acetylcysteinyl-glucosaminyl-inositol) S-conjugate amidase, it recycles conjugated MSH to the N-acetyl cysteine conjugate (AcCys S-conjugate, a mercapturic acid) and the MSH precursor. Involved in MSH-dependent detoxification of a number of alkylating agents and antibiotics.|||Belongs to the MshB deacetylase family. Mca subfamily.|||Binds 1 zinc ion per subunit.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS21060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/2174846:DDW44_RS02330 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN10 ^@ Activity Regulation|||Caution|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS16445 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUV0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the H(+)-translocating pyrophosphatase (TC 3.A.10) family. K(+)-insensitive subfamily.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton pump that utilizes the energy of pyrophosphate hydrolysis as the driving force for proton movement across the membrane. Generates a proton motive force. http://togogenome.org/gene/2174846:DDW44_RS25200 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZB5 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/2174846:DDW44_RS18050 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVR0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS30250 ^@ http://purl.uniprot.org/uniprot/A0A2S1T261 ^@ Similarity ^@ Belongs to the MmpS family. http://togogenome.org/gene/2174846:DDW44_RS12290 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS20360 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWS4 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/2174846:DDW44_RS19090 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW60 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Catalyzes the reversible hydration of carbon dioxide to form bicarbonate.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/2174846:DDW44_RS06090 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPY9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS19125 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW98 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS24850 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZH0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. http://togogenome.org/gene/2174846:DDW44_RS21275 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXA5 ^@ Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Homotetramer. http://togogenome.org/gene/2174846:DDW44_RS27740 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS29475 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1C8 ^@ Similarity ^@ Belongs to the peptidase S1 family. http://togogenome.org/gene/2174846:DDW44_RS29650 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1G6 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS22930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY06 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/2174846:DDW44_RS04415 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS17870 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN0 ^@ Similarity ^@ Belongs to the UPF0336 family. http://togogenome.org/gene/2174846:DDW44_RS10325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS72 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/2174846:DDW44_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ArgR family.|||Cytoplasm|||Regulates arginine biosynthesis genes. http://togogenome.org/gene/2174846:DDW44_RS20985 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX42 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type A subfamily.|||Binds 1 zinc ion per subunit.|||Binds the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/2174846:DDW44_RS07130 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS12725 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS19450 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWC0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS18080 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/2174846:DDW44_RS08250 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS24770 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3I6 ^@ Caution|||Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS01685 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMJ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the MurCDEF family. MurT subfamily.|||Forms a heterodimer with GatD.|||The lipid II isoglutaminyl synthase complex catalyzes the formation of alpha-D-isoglutamine in the cell wall lipid II stem peptide. The MurT subunit catalyzes the ATP-dependent amidation of D-glutamate residue of lipid II, converting it to an isoglutamine residue. http://togogenome.org/gene/2174846:DDW44_RS02270 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMW8 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/2174846:DDW44_RS17610 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Cell membrane|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS25770 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZL9 ^@ Function|||Similarity ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin. http://togogenome.org/gene/2174846:DDW44_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A2S1SML2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS20495 ^@ http://purl.uniprot.org/uniprot/A0A2S1SX85 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/2174846:DDW44_RS30005 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CbxX/CfxQ family.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS18165 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/2174846:DDW44_RS02920 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS15060 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/2174846:DDW44_RS13335 ^@ http://purl.uniprot.org/uniprot/A0A2S1STE4 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/2174846:DDW44_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPB9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/2174846:DDW44_RS18045 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVN7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/2174846:DDW44_RS11425 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSH0 ^@ Function|||Similarity ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. http://togogenome.org/gene/2174846:DDW44_RS09610 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRN8 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the first step in the biosynthesis of NAD from nicotinic acid, the ATP-dependent synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/2174846:DDW44_RS06095 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPS0 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/2174846:DDW44_RS17950 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVM2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/2174846:DDW44_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNX0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS03895 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNV4 ^@ Similarity ^@ Belongs to the class-II DAHP synthase family. http://togogenome.org/gene/2174846:DDW44_RS11850 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSL6 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS11215 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSC2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/2174846:DDW44_RS11800 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSK8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/2174846:DDW44_RS22925 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY04 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/2174846:DDW44_RS11435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSF1 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/2174846:DDW44_RS31110 ^@ http://purl.uniprot.org/uniprot/A0A2S1T262 ^@ Similarity ^@ Belongs to the PrpF family. http://togogenome.org/gene/2174846:DDW44_RS18160 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/2174846:DDW44_RS15970 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUN1 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. http://togogenome.org/gene/2174846:DDW44_RS11380 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSD3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/2174846:DDW44_RS02065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMT4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/2174846:DDW44_RS17670 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVG6 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/2174846:DDW44_RS19575 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWD2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SM43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN73 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2174846:DDW44_RS02455 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS28845 ^@ http://purl.uniprot.org/uniprot/A0A2S1T109 ^@ Function|||Similarity ^@ Belongs to the gas vesicle protein type A family.|||Gas vesicles are small, hollow, gas filled protein structures that are found in several microbial planktonic microorganisms. They allow the positioning of the organism at the favorable depth for growth. http://togogenome.org/gene/2174846:DDW44_RS12845 ^@ http://purl.uniprot.org/uniprot/A0A2S1ST61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS27215 ^@ http://purl.uniprot.org/uniprot/A0A2S1T092 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/2174846:DDW44_RS22285 ^@ http://purl.uniprot.org/uniprot/A0A2S1T3E7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by GTP. Inhibited by UTP.|||Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS01695 ^@ http://purl.uniprot.org/uniprot/A0A2S1SML1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. Mixed-substrate PFK group III subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS12335 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSX8 ^@ Similarity ^@ Belongs to the FAD-binding monooxygenase family. http://togogenome.org/gene/2174846:DDW44_RS18545 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVY3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS17200 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS15625 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS28860 ^@ http://purl.uniprot.org/uniprot/A0A2S1T167 ^@ Function|||Subcellular Location Annotation ^@ May play a structural or regulatory role in gas vesicle synthesis.|||Vesicle|||gas vesicle http://togogenome.org/gene/2174846:DDW44_RS17410 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVC2 ^@ Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnA subfamily.|||Catalyzes the dehydration of chorismate into 3-[(1-carboxyvinyl)oxy]benzoate, a step in the biosynthesis of menaquinone (MK, vitamin K2). http://togogenome.org/gene/2174846:DDW44_RS10720 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS33 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS09760 ^@ http://purl.uniprot.org/uniprot/A0A2S1SRL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS29860 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1K7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Heterodimer of an alpha and a beta subunit.|||The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/2174846:DDW44_RS25420 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS17625 ^@ http://purl.uniprot.org/uniprot/A0A2S1T337 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02265 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMW5 ^@ Similarity|||Subunit ^@ Belongs to the AAA ATPase family.|||Homohexamer. Assembles into a hexameric ring structure. http://togogenome.org/gene/2174846:DDW44_RS24660 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYV7 ^@ Similarity ^@ Belongs to the universal stress protein A family. http://togogenome.org/gene/2174846:DDW44_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17450 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS15255 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU98 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/2174846:DDW44_RS18170 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW39 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/2174846:DDW44_RS26715 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS25285 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZP6 ^@ Similarity ^@ Belongs to the anti-sigma-factor antagonist family. http://togogenome.org/gene/2174846:DDW44_RS24360 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYV4 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS10930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS02885 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN63 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS17405 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVC0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS11490 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS18885 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW42 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS26485 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS08100 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/2174846:DDW44_RS17490 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 23 kDa subunit family.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be ubiquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS19190 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS15720 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUI5 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS18100 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVP4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/2174846:DDW44_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNL3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/2174846:DDW44_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2K7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 3 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS22715 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS19010 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW61 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine. http://togogenome.org/gene/2174846:DDW44_RS19880 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS10555 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2T7 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/2174846:DDW44_RS10770 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/2174846:DDW44_RS02895 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNC4 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/2174846:DDW44_RS22210 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXS4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/2174846:DDW44_RS24020 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYM9 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/2174846:DDW44_RS05160 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPD3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2174846:DDW44_RS20370 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the drug/metabolite transporter (DMT) superfamily. Small multidrug resistance (SMR) (TC 2.A.7.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/2174846:DDW44_RS01265 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMG9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/2174846:DDW44_RS12055 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSR0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS27780 ^@ http://purl.uniprot.org/uniprot/A0A2S1T0N5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/2174846:DDW44_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP47 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/2174846:DDW44_RS05330 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/2174846:DDW44_RS15265 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrgA family.|||Cell membrane|||Involved in cell division. http://togogenome.org/gene/2174846:DDW44_RS06585 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ30 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the acetyltransferase family. MshD subfamily.|||Catalyzes the transfer of acetyl from acetyl-CoA to desacetylmycothiol (Cys-GlcN-Ins) to form mycothiol.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/2174846:DDW44_RS22875 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXZ5 ^@ Similarity ^@ Belongs to the WXG100 family. http://togogenome.org/gene/2174846:DDW44_RS18510 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVZ1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/2174846:DDW44_RS22140 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/2174846:DDW44_RS08450 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/2174846:DDW44_RS09765 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2T2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/2174846:DDW44_RS16730 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV06 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/2174846:DDW44_RS13570 ^@ http://purl.uniprot.org/uniprot/A0A2S1STH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS17665 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVH2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/2174846:DDW44_RS12820 ^@ http://purl.uniprot.org/uniprot/A0A2S1STC2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/2174846:DDW44_RS11460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSF0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS27035 ^@ http://purl.uniprot.org/uniprot/A0A2S1T073 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SsgA family.|||Cell septum http://togogenome.org/gene/2174846:DDW44_RS28825 ^@ http://purl.uniprot.org/uniprot/A0A2S1T112 ^@ Function|||Subcellular Location Annotation ^@ May play a structural or regulatory role in gas vesicle synthesis.|||Vesicle|||gas vesicle http://togogenome.org/gene/2174846:DDW44_RS15095 ^@ http://purl.uniprot.org/uniprot/A0A2S1SUI1 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS18875 ^@ http://purl.uniprot.org/uniprot/A0A2S1SW20 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS12425 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSY8 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/2174846:DDW44_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPL5 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/2174846:DDW44_RS14980 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU75 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/2174846:DDW44_RS22065 ^@ http://purl.uniprot.org/uniprot/A0A2S1SY56 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/2174846:DDW44_RS05430 ^@ http://purl.uniprot.org/uniprot/A0A2S1T2P3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS08260 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/2174846:DDW44_RS16780 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV16 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/2174846:DDW44_RS11575 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/2174846:DDW44_RS26330 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZS7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPU3 ^@ Similarity ^@ Belongs to the UPF0337 (CsbD) family. http://togogenome.org/gene/2174846:DDW44_RS27235 ^@ http://purl.uniprot.org/uniprot/A0A2S1T080 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/2174846:DDW44_RS22435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXS6 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/2174846:DDW44_RS01935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMS7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS19325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWA5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17455 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 20 kDa subunit family.|||Binds 1 [4Fe-4S] cluster.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS01370 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMI9 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/2174846:DDW44_RS24435 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYW1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/2174846:DDW44_RS11175 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS96 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/2174846:DDW44_RS25560 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZE6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS17325 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVA6 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/2174846:DDW44_RS04275 ^@ http://purl.uniprot.org/uniprot/A0A2S1SNX7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/2174846:DDW44_RS25930 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZL3 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/2174846:DDW44_RS16740 ^@ http://purl.uniprot.org/uniprot/A0A2S1SV01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS06615 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/2174846:DDW44_RS17995 ^@ http://purl.uniprot.org/uniprot/A0A2S1T336 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/2174846:DDW44_RS10630 ^@ http://purl.uniprot.org/uniprot/A0A2S1SS50 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/2174846:DDW44_RS29185 ^@ http://purl.uniprot.org/uniprot/A0A2S1T190 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS20425 ^@ http://purl.uniprot.org/uniprot/A0A2S1SWU5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/2174846:DDW44_RS06635 ^@ http://purl.uniprot.org/uniprot/A0A2S1SQ40 ^@ Similarity ^@ Belongs to the PhoU family.|||Belongs to the UPF0111 family. http://togogenome.org/gene/2174846:DDW44_RS21925 ^@ http://purl.uniprot.org/uniprot/A0A2S1SXM8 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/2174846:DDW44_RS02935 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/2174846:DDW44_RS17460 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I 30 kDa subunit family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoB, C, D, E, F, and G constitute the peripheral sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS02715 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN88 ^@ Function|||Similarity ^@ Belongs to the ectoine synthase family.|||Catalyzes the circularization of gamma-N-acetyl-alpha,gamma-diaminobutyric acid (ADABA) to ectoine (1,4,5,6-tetrahydro-2-methyl-4-pyrimidine carboxylic acid), which is an excellent osmoprotectant. http://togogenome.org/gene/2174846:DDW44_RS02870 ^@ http://purl.uniprot.org/uniprot/A0A2S1SN76 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS11530 ^@ http://purl.uniprot.org/uniprot/A0A2S1SSI5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/2174846:DDW44_RS08555 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/2174846:DDW44_RS08995 ^@ http://purl.uniprot.org/uniprot/A0A2S1SR93 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/2174846:DDW44_RS02125 ^@ http://purl.uniprot.org/uniprot/A0A2S1SMU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/2174846:DDW44_RS29855 ^@ http://purl.uniprot.org/uniprot/A0A2S1T1P5 ^@ Function|||Subunit ^@ Heterodimer of an alpha and a beta subunit.|||The electron transfer flavoprotein serves as a specific electron acceptor for other dehydrogenases. It transfers the electrons to the main respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/2174846:DDW44_RS23880 ^@ http://purl.uniprot.org/uniprot/A0A2S1SYL3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/2174846:DDW44_RS17585 ^@ http://purl.uniprot.org/uniprot/A0A2S1SVT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I subunit 3 family.|||Cell membrane|||NDH-1 is composed of 14 different subunits. Subunits NuoA, H, J, K, L, M, N constitute the membrane sector of the complex.|||NDH-1 shuttles electrons from NADH, via FMN and iron-sulfur (Fe-S) centers, to quinones in the respiratory chain. The immediate electron acceptor for the enzyme in this species is believed to be a menaquinone. Couples the redox reaction to proton translocation (for every two electrons transferred, four hydrogen ions are translocated across the cytoplasmic membrane), and thus conserves the redox energy in a proton gradient. http://togogenome.org/gene/2174846:DDW44_RS04500 ^@ http://purl.uniprot.org/uniprot/A0A2S1SP17 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS15070 ^@ http://purl.uniprot.org/uniprot/A0A2S1SU70 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/2174846:DDW44_RS29205 ^@ http://purl.uniprot.org/uniprot/A0A2S1T174 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/2174846:DDW44_RS24695 ^@ http://purl.uniprot.org/uniprot/A0A2S1SZ15 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/2174846:DDW44_RS05215 ^@ http://purl.uniprot.org/uniprot/A0A2S1SPE8 ^@ Similarity ^@ Belongs to the PTPS family. QueD subfamily. http://togogenome.org/gene/2174846:DDW44_RS13285 ^@ http://purl.uniprot.org/uniprot/A0A2S1STC9 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family.