http://togogenome.org/gene/229533:FGSG_01741 ^@ http://purl.uniprot.org/uniprot/I1RDN1 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_04481 ^@ http://purl.uniprot.org/uniprot/I1RKR5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/229533:FGSG_02206 ^@ http://purl.uniprot.org/uniprot/I1REV2 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/229533:FGSG_06807 ^@ http://purl.uniprot.org/uniprot/I1RRS1 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/229533:FGSG_00612 ^@ http://purl.uniprot.org/uniprot/V6QU20 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_12120 ^@ http://purl.uniprot.org/uniprot/I1S5J9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00280 ^@ http://purl.uniprot.org/uniprot/I1R9W6 ^@ Similarity ^@ Belongs to the acetyltransferase family. GCN5 subfamily. http://togogenome.org/gene/229533:FGSG_09409 ^@ http://purl.uniprot.org/uniprot/I1RYF9 ^@ Function|||Similarity ^@ Belongs to the BLOC1S4 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting. http://togogenome.org/gene/229533:FGSG_04178 ^@ http://purl.uniprot.org/uniprot/I1RJZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02659 ^@ http://purl.uniprot.org/uniprot/I1RG11 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/229533:FGSG_00286 ^@ http://purl.uniprot.org/uniprot/I1R9X2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic initiation factor 4E family.|||Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures. http://togogenome.org/gene/229533:FGSG_09392 ^@ http://purl.uniprot.org/uniprot/I1RYE5 ^@ Function|||Similarity|||Subunit ^@ Associates with the respiratory chain complex III/complex IV supercomplex.|||Belongs to the RCF1 family.|||Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes. http://togogenome.org/gene/229533:FGSG_06573 ^@ http://purl.uniprot.org/uniprot/I1RR61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 22 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01972 ^@ http://purl.uniprot.org/uniprot/I1RE90 ^@ Similarity ^@ In the N-terminal section; belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_07674 ^@ http://purl.uniprot.org/uniprot/I1RU04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01057 ^@ http://purl.uniprot.org/uniprot/I1RBW6 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/229533:FGSG_00375 ^@ http://purl.uniprot.org/uniprot/I1RA51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Belongs to the paxM FAD-dependent monooxygenase family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_07088 ^@ http://purl.uniprot.org/uniprot/I1RSH0 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/229533:FGSG_00529 ^@ http://purl.uniprot.org/uniprot/V6QVL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04611 ^@ http://purl.uniprot.org/uniprot/I1RL31 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/229533:FGSG_13920 ^@ http://purl.uniprot.org/uniprot/I1SAN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02567 ^@ http://purl.uniprot.org/uniprot/A0A1I9F2V6|||http://purl.uniprot.org/uniprot/Q4IJP1 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus|||Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3. http://togogenome.org/gene/229533:FGSG_12996 ^@ http://purl.uniprot.org/uniprot/A0A1I9FI54|||http://purl.uniprot.org/uniprot/Q4I7G0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DPH4 family.|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).|||Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2.|||The DPH-type metal-binding (MB) domain can bind either zinc or iron ions. http://togogenome.org/gene/229533:FGSG_02945 ^@ http://purl.uniprot.org/uniprot/I1RGS1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13231 ^@ http://purl.uniprot.org/uniprot/I1S8Q3 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Cytoplasm|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).|||Preautophagosomal structure membrane|||Probable sterol 3-beta-glucosyltransferase that mediates autophagic degradation of peroxisomes (pexophagy) (By similarity). Also required for cytoplasm to vacuole transport (Cvt) and autophagic degradation of mitochondria (mitophagy) and nuclei (nucleophagy) (By similarity).|||The GRAM and PH domains are required for the localization of ATG26 to the preautophagosomal structure (PAS) and are involved in autophagy (By similarity). http://togogenome.org/gene/229533:FGSG_02869 ^@ http://purl.uniprot.org/uniprot/I1RGJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03657 ^@ http://purl.uniprot.org/uniprot/I1RIL9 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_07594 ^@ http://purl.uniprot.org/uniprot/I1RTS8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_10385 ^@ http://purl.uniprot.org/uniprot/I1S0Z3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/229533:FGSG_10918 ^@ http://purl.uniprot.org/uniprot/I1S2C9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02339 ^@ http://purl.uniprot.org/uniprot/I1RF73 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/229533:FGSG_10949 ^@ http://purl.uniprot.org/uniprot/Q4HVQ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_12851 ^@ http://purl.uniprot.org/uniprot/I1S7M8 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/229533:FGSG_11504 ^@ http://purl.uniprot.org/uniprot/I1S3V6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01918 ^@ http://purl.uniprot.org/uniprot/I1RE45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09078 ^@ http://purl.uniprot.org/uniprot/I1RXK7 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_11182 ^@ http://purl.uniprot.org/uniprot/I1S321 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07596 ^@ http://purl.uniprot.org/uniprot/I1RTT0 ^@ Similarity ^@ In the N-terminal section; belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_04182 ^@ http://purl.uniprot.org/uniprot/I1RJZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11976 ^@ http://purl.uniprot.org/uniprot/I1S558 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_12519 ^@ http://purl.uniprot.org/uniprot/I1S6P6 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/229533:FGSG_02565 ^@ http://purl.uniprot.org/uniprot/I1RFS7 ^@ Function|||Similarity ^@ Belongs to the VPS16 family.|||Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. http://togogenome.org/gene/229533:FGSG_11720 ^@ http://purl.uniprot.org/uniprot/I1S4F3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09668 ^@ http://purl.uniprot.org/uniprot/A0A1I9FI29|||http://purl.uniprot.org/uniprot/Q4HZE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG10 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_05379 ^@ http://purl.uniprot.org/uniprot/I1RN19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04408 ^@ http://purl.uniprot.org/uniprot/I1RKJ8 ^@ Similarity ^@ Belongs to the helicase family. Dicer subfamily. http://togogenome.org/gene/229533:FGSG_01398 ^@ http://purl.uniprot.org/uniprot/V6QXP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/229533:FGSG_03991 ^@ http://purl.uniprot.org/uniprot/I1RJH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DSS1/SEM1 family.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins.|||Nucleus http://togogenome.org/gene/229533:FGSG_03345 ^@ http://purl.uniprot.org/uniprot/I1RHT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00365 ^@ http://purl.uniprot.org/uniprot/V6QUE6 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/229533:FGSG_00597 ^@ http://purl.uniprot.org/uniprot/I1RAR2 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/229533:FGSG_10765 ^@ http://purl.uniprot.org/uniprot/A0A1I9FWM3|||http://purl.uniprot.org/uniprot/Q4HW93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLD2 family.|||Cytoplasm|||Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).|||Has a role in the initiation of DNA replication. Required at S-phase checkpoint.|||Nucleus http://togogenome.org/gene/229533:FGSG_09111 ^@ http://purl.uniprot.org/uniprot/I1RXN7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11824 ^@ http://purl.uniprot.org/uniprot/I1S4Q6 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/229533:FGSG_04780 ^@ http://purl.uniprot.org/uniprot/I1RLH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06047 ^@ http://purl.uniprot.org/uniprot/I1RPR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Chromosome http://togogenome.org/gene/229533:FGSG_08781 ^@ http://purl.uniprot.org/uniprot/I1RWU6 ^@ Similarity ^@ Belongs to the ERT1/acuK family. http://togogenome.org/gene/229533:FGSG_00571 ^@ http://purl.uniprot.org/uniprot/I1RAN9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 7 (cellulase C) family. http://togogenome.org/gene/229533:FGSG_01743 ^@ http://purl.uniprot.org/uniprot/I1RDN3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_10301 ^@ http://purl.uniprot.org/uniprot/I1S0R4 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/229533:FGSG_01138 ^@ http://purl.uniprot.org/uniprot/I1RC36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Endoplasmic reticulum membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/229533:FGSG_00537 ^@ http://purl.uniprot.org/uniprot/I1RAK6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11714 ^@ http://purl.uniprot.org/uniprot/I1S4E7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-beta-HSD family.|||Endoplasmic reticulum membrane|||Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol-4-alpha-carboxylate 3-dehydrogenase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG26 is a catalytic component of the C-4 demethylation complex that catalyzes the conversion of 4,4-dimethylfecosterol into fecosterol via 4-methylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_01652 ^@ http://purl.uniprot.org/uniprot/I1RDF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Heterodimer with ALG13 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER.|||Membrane|||Nucleus membrane http://togogenome.org/gene/229533:FGSG_07257 ^@ http://purl.uniprot.org/uniprot/I1RSX0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/229533:FGSG_03438 ^@ http://purl.uniprot.org/uniprot/I1RI18 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_07288 ^@ http://purl.uniprot.org/uniprot/I1RT00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/229533:FGSG_03202 ^@ http://purl.uniprot.org/uniprot/I1RHF2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_05859 ^@ http://purl.uniprot.org/uniprot/I1RPA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09435 ^@ http://purl.uniprot.org/uniprot/I1RYI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHO1 family.|||Cell membrane|||Forms homooligomers.|||Membrane|||Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. http://togogenome.org/gene/229533:FGSG_07334 ^@ http://purl.uniprot.org/uniprot/A0A1I9FGZ2|||http://purl.uniprot.org/uniprot/Q4I624 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FES1 family.|||Cytoplasm|||Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity).|||Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins. http://togogenome.org/gene/229533:FGSG_04430 ^@ http://purl.uniprot.org/uniprot/I1RKL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_00388 ^@ http://purl.uniprot.org/uniprot/I1RA63 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/229533:FGSG_10907 ^@ http://purl.uniprot.org/uniprot/I1S2B9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/229533:FGSG_00886 ^@ http://purl.uniprot.org/uniprot/I1RBG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures.|||Belongs to the dynein light chain family.|||Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs).|||cytoskeleton|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_10965 ^@ http://purl.uniprot.org/uniprot/I1S2H1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/229533:FGSG_04113 ^@ http://purl.uniprot.org/uniprot/I1RJT1 ^@ Subcellular Location Annotation ^@ Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_03102 ^@ http://purl.uniprot.org/uniprot/I1RH59 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04637 ^@ http://purl.uniprot.org/uniprot/I1RL54 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11552 ^@ http://purl.uniprot.org/uniprot/I1S400 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10044 ^@ http://purl.uniprot.org/uniprot/I1S030 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12409 ^@ http://purl.uniprot.org/uniprot/I1S6D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05525 ^@ http://purl.uniprot.org/uniprot/I1RNE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/229533:FGSG_09184 ^@ http://purl.uniprot.org/uniprot/I1RXV8 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_03963 ^@ http://purl.uniprot.org/uniprot/I1RJE7 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/229533:FGSG_04929 ^@ http://purl.uniprot.org/uniprot/I1RLV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/229533:FGSG_07440 ^@ http://purl.uniprot.org/uniprot/I1RTD7 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/229533:FGSG_07051 ^@ http://purl.uniprot.org/uniprot/I1RSD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00194 ^@ http://purl.uniprot.org/uniprot/I1R9P1 ^@ Similarity ^@ Belongs to the serine esterase family. http://togogenome.org/gene/229533:FGSG_06613 ^@ http://purl.uniprot.org/uniprot/I1RR97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_04369 ^@ http://purl.uniprot.org/uniprot/I1RKG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00721 ^@ http://purl.uniprot.org/uniprot/I1RB18 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_01839 ^@ http://purl.uniprot.org/uniprot/I1RDX0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. http://togogenome.org/gene/229533:FGSG_09181 ^@ http://purl.uniprot.org/uniprot/I1RXV5 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_10757 ^@ http://purl.uniprot.org/uniprot/I1S1X9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/229533:FGSG_06761 ^@ http://purl.uniprot.org/uniprot/I1RRM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_10531 ^@ http://purl.uniprot.org/uniprot/I1S1D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07721 ^@ http://purl.uniprot.org/uniprot/I1RU42 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_09250 ^@ http://purl.uniprot.org/uniprot/I1RY21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_07466 ^@ http://purl.uniprot.org/uniprot/I1RTG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_05045 ^@ http://purl.uniprot.org/uniprot/I1RM63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/229533:FGSG_12244 ^@ http://purl.uniprot.org/uniprot/I1S5X3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10995 ^@ http://purl.uniprot.org/uniprot/I1S2J9 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ ABC transporter; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).|||Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Leads to reduced virulence (PubMed:23266949, PubMed:30804501). Results in a substantial increase of fusaoctaxin A, and abolishes the production of fusapentaxin A and fusatrixin A (PubMed:31100892). http://togogenome.org/gene/229533:FGSG_00967 ^@ http://purl.uniprot.org/uniprot/I1RBN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05244 ^@ http://purl.uniprot.org/uniprot/I1RMQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10186 ^@ http://purl.uniprot.org/uniprot/I1S0G0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_04642 ^@ http://purl.uniprot.org/uniprot/I1RL59 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_06606 ^@ http://purl.uniprot.org/uniprot/I1RR90 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:21436218). Catalyzes the reduction of the C14=C15 double bond within 4,4,24-trimethyl ergosta-8,14,24(28)-trienolto produce 4,4-dimethylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||In contrast to the disruption of ERG24B, does not affect sensitivity to amine fungicides. http://togogenome.org/gene/229533:FGSG_10534 ^@ http://purl.uniprot.org/uniprot/I1S1D4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_09041 ^@ http://purl.uniprot.org/uniprot/I1RXH2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/229533:FGSG_11603 ^@ http://purl.uniprot.org/uniprot/V6R227 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_01767 ^@ http://purl.uniprot.org/uniprot/I1RDQ3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_10903 ^@ http://purl.uniprot.org/uniprot/I1S2B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/229533:FGSG_08577 ^@ http://purl.uniprot.org/uniprot/I1RWB4 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/229533:FGSG_01390 ^@ http://purl.uniprot.org/uniprot/I1RCR4 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_11262 ^@ http://purl.uniprot.org/uniprot/I1S389 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03960 ^@ http://purl.uniprot.org/uniprot/I1RJE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal hydrophobin family.|||cell wall http://togogenome.org/gene/229533:FGSG_04643 ^@ http://purl.uniprot.org/uniprot/I1RL60 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11124 ^@ http://purl.uniprot.org/uniprot/I1S2W8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03497 ^@ http://purl.uniprot.org/uniprot/I1RI71 ^@ Function|||Similarity ^@ Belongs to the peptidase S1C family.|||Nuclear serine protease which mediates apoptosis. http://togogenome.org/gene/229533:FGSG_01758 ^@ http://purl.uniprot.org/uniprot/I1RDP5 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/229533:FGSG_06161 ^@ http://purl.uniprot.org/uniprot/I1RQ28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.|||nucleolus http://togogenome.org/gene/229533:FGSG_08042 ^@ http://purl.uniprot.org/uniprot/I1RUY3 ^@ Function|||Similarity ^@ Belongs to the dihydroxyacetone kinase (DAK) family.|||Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. http://togogenome.org/gene/229533:FGSG_07567 ^@ http://purl.uniprot.org/uniprot/I1RTQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00530 ^@ http://purl.uniprot.org/uniprot/I1RAJ9 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/229533:FGSG_10795 ^@ http://purl.uniprot.org/uniprot/I1S214 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_04356 ^@ http://purl.uniprot.org/uniprot/I1RKF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08011 ^@ http://purl.uniprot.org/uniprot/I1RUV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_00177 ^@ http://purl.uniprot.org/uniprot/V6R0A3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_09878 ^@ http://purl.uniprot.org/uniprot/I1RZM8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/229533:FGSG_05902 ^@ http://purl.uniprot.org/uniprot/A0A1I9FR14|||http://purl.uniprot.org/uniprot/Q4IA56 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-independent protease that degrades mitochondrial transit peptides after their cleavage. Also degrades other unstructured peptides.|||Belongs to the peptidase M16 family. PreP subfamily.|||Binds 1 zinc ion per subunit.|||Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).|||Mitochondrion intermembrane space|||Mitochondrion matrix|||Monomer and homodimer; homodimerization is induced by binding of the substrate. http://togogenome.org/gene/229533:FGSG_02636 ^@ http://purl.uniprot.org/uniprot/I1RFZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||Endoplasmic reticulum membrane|||May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane.|||Membrane http://togogenome.org/gene/229533:FGSG_05049 ^@ http://purl.uniprot.org/uniprot/I1RM67 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. http://togogenome.org/gene/229533:FGSG_03917 ^@ http://purl.uniprot.org/uniprot/I1RJA8 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/229533:FGSG_08508 ^@ http://purl.uniprot.org/uniprot/I1RW53 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_11048 ^@ http://purl.uniprot.org/uniprot/I1S2P8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 53 family. http://togogenome.org/gene/229533:FGSG_07004 ^@ http://purl.uniprot.org/uniprot/I1RS90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Endomembrane system|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_08620 ^@ http://purl.uniprot.org/uniprot/I1RWF4 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/229533:FGSG_05731 ^@ http://purl.uniprot.org/uniprot/I1RNY5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07456 ^@ http://purl.uniprot.org/uniprot/I1RTF3 ^@ Function|||Similarity ^@ Belongs to the MUB1/samB family.|||Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation. http://togogenome.org/gene/229533:FGSG_06894 ^@ http://purl.uniprot.org/uniprot/I1RRZ0 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/229533:FGSG_06224 ^@ http://purl.uniprot.org/uniprot/I1RQ85 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/229533:FGSG_10706 ^@ http://purl.uniprot.org/uniprot/I1S1T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_11030 ^@ http://purl.uniprot.org/uniprot/I1S2N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02782 ^@ http://purl.uniprot.org/uniprot/I1RGC3 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/229533:FGSG_07306 ^@ http://purl.uniprot.org/uniprot/I1RT16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02478 ^@ http://purl.uniprot.org/uniprot/I1RFJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_08879 ^@ http://purl.uniprot.org/uniprot/A0A1I9FAD5|||http://purl.uniprot.org/uniprot/Q4I1M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase.|||Belongs to the TRM44 family.|||Cytoplasm|||Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. http://togogenome.org/gene/229533:FGSG_09721 ^@ http://purl.uniprot.org/uniprot/I1RZ91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the END3 family.|||Cell membrane|||Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.|||Component of the PAN1 actin cytoskeleton-regulatory complex.|||Endosome membrane|||Membrane|||actin patch http://togogenome.org/gene/229533:FGSG_12069 ^@ http://purl.uniprot.org/uniprot/I1S5F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_04264 ^@ http://purl.uniprot.org/uniprot/I1RK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01233 ^@ http://purl.uniprot.org/uniprot/I1RCC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.|||Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_08045 ^@ http://purl.uniprot.org/uniprot/I1RUY6 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/229533:FGSG_01789 ^@ http://purl.uniprot.org/uniprot/I1RDS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09104 ^@ http://purl.uniprot.org/uniprot/I1RXN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00219 ^@ http://purl.uniprot.org/uniprot/I1R9R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01582 ^@ http://purl.uniprot.org/uniprot/I1RD90 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/229533:FGSG_09940 ^@ http://purl.uniprot.org/uniprot/I1RZT6 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/229533:FGSG_09899 ^@ http://purl.uniprot.org/uniprot/I1RZP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09263 ^@ http://purl.uniprot.org/uniprot/I1RY32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the peroxisomal translocation machinery.|||Peroxisome membrane http://togogenome.org/gene/229533:FGSG_13755 ^@ http://purl.uniprot.org/uniprot/I1SA74 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_11413 ^@ http://purl.uniprot.org/uniprot/I1S3M4 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_11815 ^@ http://purl.uniprot.org/uniprot/I1S4P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11272 ^@ http://purl.uniprot.org/uniprot/I1S397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_13549 ^@ http://purl.uniprot.org/uniprot/I1S9L8 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/229533:FGSG_05365 ^@ http://purl.uniprot.org/uniprot/I1RN08 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/229533:FGSG_04700 ^@ http://purl.uniprot.org/uniprot/I1RLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09607 ^@ http://purl.uniprot.org/uniprot/I1RYZ1 ^@ Subunit ^@ Consists of at least two heavy chains and a number of intermediate and light chains. http://togogenome.org/gene/229533:FGSG_01935 ^@ http://purl.uniprot.org/uniprot/A0A1I9F0K9|||http://purl.uniprot.org/uniprot/Q4ILH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity).|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/229533:FGSG_02382 ^@ http://purl.uniprot.org/uniprot/I1RFB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07164 ^@ http://purl.uniprot.org/uniprot/I1RSN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09974 ^@ http://purl.uniprot.org/uniprot/I1RZW8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/229533:FGSG_09816 ^@ http://purl.uniprot.org/uniprot/A0A1I9FPC3|||http://purl.uniprot.org/uniprot/Q4HYZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EXO84 family.|||Component of the exocyst complex.|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).|||Vesicle|||secretory vesicle http://togogenome.org/gene/229533:FGSG_07292 ^@ http://purl.uniprot.org/uniprot/I1RT04 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/229533:FGSG_09056 ^@ http://purl.uniprot.org/uniprot/I1RXI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03436 ^@ http://purl.uniprot.org/uniprot/I1RI16 ^@ Similarity ^@ Belongs to the chloroperoxidase family. http://togogenome.org/gene/229533:FGSG_13674 ^@ http://purl.uniprot.org/uniprot/I1S9Z3 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/229533:FGSG_01020 ^@ http://purl.uniprot.org/uniprot/I1RBT0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.|||Membrane http://togogenome.org/gene/229533:FGSG_09786 ^@ http://purl.uniprot.org/uniprot/I1RZE7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Cell membrane|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. http://togogenome.org/gene/229533:FGSG_02045 ^@ http://purl.uniprot.org/uniprot/I1REF7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/229533:FGSG_04277 ^@ http://purl.uniprot.org/uniprot/I1RK83 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/229533:FGSG_03124 ^@ http://purl.uniprot.org/uniprot/I1RH79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_06683 ^@ http://purl.uniprot.org/uniprot/I1RRG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09279 ^@ http://purl.uniprot.org/uniprot/I1RY46 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_05042 ^@ http://purl.uniprot.org/uniprot/V6R9L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00068 ^@ http://purl.uniprot.org/uniprot/I1R9D3 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase.|||Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. http://togogenome.org/gene/229533:FGSG_01361 ^@ http://purl.uniprot.org/uniprot/I1RCN8 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_08509 ^@ http://purl.uniprot.org/uniprot/I1RW54 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/229533:FGSG_08084 ^@ http://purl.uniprot.org/uniprot/I1RV24 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Highly expressed under trichothecene-producing conditions.|||MFS-type transporter; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat.|||Membrane http://togogenome.org/gene/229533:FGSG_13118 ^@ http://purl.uniprot.org/uniprot/I1S8E0 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/229533:FGSG_00467 ^@ http://purl.uniprot.org/uniprot/I1RAE0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/229533:FGSG_04237 ^@ http://purl.uniprot.org/uniprot/I1RK49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/229533:FGSG_05288 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQE3|||http://purl.uniprot.org/uniprot/Q4IBX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NUF2 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_07429 ^@ http://purl.uniprot.org/uniprot/I1RTC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/229533:FGSG_08121 ^@ http://purl.uniprot.org/uniprot/I1RV59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07720 ^@ http://purl.uniprot.org/uniprot/I1RU41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07396 ^@ http://purl.uniprot.org/uniprot/I1RT95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_03055 ^@ http://purl.uniprot.org/uniprot/I1RH18 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01891 ^@ http://purl.uniprot.org/uniprot/I1RE19 ^@ Function|||Similarity ^@ Belongs to the calmodulin family.|||May be involved in calcium-mediated signal transduction. http://togogenome.org/gene/229533:FGSG_05862 ^@ http://purl.uniprot.org/uniprot/I1RPA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/229533:FGSG_00631 ^@ http://purl.uniprot.org/uniprot/I1RAU5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/229533:FGSG_07474 ^@ http://purl.uniprot.org/uniprot/I1RTH0 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/229533:FGSG_05924 ^@ http://purl.uniprot.org/uniprot/I1RPF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03934 ^@ http://purl.uniprot.org/uniprot/I1RJC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04179 ^@ http://purl.uniprot.org/uniprot/I1RJZ5 ^@ Function|||Similarity ^@ Belongs to the POA1 family.|||Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. http://togogenome.org/gene/229533:FGSG_06959 ^@ http://purl.uniprot.org/uniprot/V6RFV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||spindle http://togogenome.org/gene/229533:FGSG_09619 ^@ http://purl.uniprot.org/uniprot/I1RZ02 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/229533:FGSG_03990 ^@ http://purl.uniprot.org/uniprot/I1RJH0 ^@ Function|||Similarity ^@ Belongs to the POA1 family.|||Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. http://togogenome.org/gene/229533:FGSG_08350 ^@ http://purl.uniprot.org/uniprot/V6RK96 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/229533:FGSG_06278 ^@ http://purl.uniprot.org/uniprot/I1RQD7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 15 family. http://togogenome.org/gene/229533:FGSG_07471 ^@ http://purl.uniprot.org/uniprot/I1RTG7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Nucleus|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/229533:FGSG_08491 ^@ http://purl.uniprot.org/uniprot/I1RW37 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy (By similarity). Involved in ATG9 and ATG23 cycling through the pre-autophagosomal structure (By similarity). Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation (By similarity). Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy (By similarity). Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Belongs to the ATG13 family. Fungi subfamily.|||Cytoplasm|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Hypophosphorylated form interacts with ATG1 to form the ATG1-ATG13 kinase complex (By similarity). The ATG1-ATG13 complex interacts with the ATG17-ATG29-ATG31 complex through direct interaction with ATG17 (By similarity).|||Preautophagosomal structure http://togogenome.org/gene/229533:FGSG_01160 ^@ http://purl.uniprot.org/uniprot/I1RC57 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13223 ^@ http://purl.uniprot.org/uniprot/I1S8P5 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_05316 ^@ http://purl.uniprot.org/uniprot/I1RMW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_12358 ^@ http://purl.uniprot.org/uniprot/I1S687 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01102 ^@ http://purl.uniprot.org/uniprot/I1RC03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||nucleolus http://togogenome.org/gene/229533:FGSG_05851 ^@ http://purl.uniprot.org/uniprot/I1RP94 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/229533:FGSG_10327 ^@ http://purl.uniprot.org/uniprot/I1S0T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chitin synthase family.|||Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_04095 ^@ http://purl.uniprot.org/uniprot/I1RJR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal Na(+)/H(+) exchanger family.|||Membrane http://togogenome.org/gene/229533:FGSG_06436 ^@ http://purl.uniprot.org/uniprot/I1RQT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08510 ^@ http://purl.uniprot.org/uniprot/I1RW55 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06811 ^@ http://purl.uniprot.org/uniprot/I1RRS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_02392 ^@ http://purl.uniprot.org/uniprot/V6R0R8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00144 ^@ http://purl.uniprot.org/uniprot/I1R9K1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12678 ^@ http://purl.uniprot.org/uniprot/I1S755 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/229533:FGSG_08917 ^@ http://purl.uniprot.org/uniprot/I1RX67 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFH5 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane|||Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses. http://togogenome.org/gene/229533:FGSG_07135 ^@ http://purl.uniprot.org/uniprot/I1RSL2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. http://togogenome.org/gene/229533:FGSG_07961 ^@ http://purl.uniprot.org/uniprot/I1RUQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RSA3 family.|||Required for efficient biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_07529 ^@ http://purl.uniprot.org/uniprot/I1RTL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08946 ^@ http://purl.uniprot.org/uniprot/I1RX92 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_06277 ^@ http://purl.uniprot.org/uniprot/I1RQD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/229533:FGSG_09365 ^@ http://purl.uniprot.org/uniprot/I1RYC0 ^@ Similarity ^@ Belongs to the LOR family. http://togogenome.org/gene/229533:FGSG_05345 ^@ http://purl.uniprot.org/uniprot/I1RMY9 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/229533:FGSG_03072 ^@ http://purl.uniprot.org/uniprot/I1RH33 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||extracellular space http://togogenome.org/gene/229533:FGSG_06319 ^@ http://purl.uniprot.org/uniprot/I1RQH6 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/229533:FGSG_04260 ^@ http://purl.uniprot.org/uniprot/V6R2Z5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_12164 ^@ http://purl.uniprot.org/uniprot/A0A1I9F2Z5|||http://purl.uniprot.org/uniprot/I1S5P3 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIT1/WOR1 family.|||Global transcriptional regulator of pathogenicity. Regulates many genes during growth in putrescine medium and during infection. Involved in the developmental processes of conidium formation and sexual reproduction and modulates a morphological change that accompanies mycotoxin production.|||Nucleus|||Results in greatly reduced pathogenicity and loss of trichothecene toxin accumulation in infected wheat plants. Exhibits normal vegetative growth but shows defects in asexual and sexual spore development. http://togogenome.org/gene/229533:FGSG_10921 ^@ http://purl.uniprot.org/uniprot/I1S2D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03967 ^@ http://purl.uniprot.org/uniprot/I1RJF1 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/229533:FGSG_07393 ^@ http://purl.uniprot.org/uniprot/A0A1I9FP77|||http://purl.uniprot.org/uniprot/Q4I5W5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT4 family.|||Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.|||centromere http://togogenome.org/gene/229533:FGSG_08511 ^@ http://purl.uniprot.org/uniprot/V6RKR9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05429 ^@ http://purl.uniprot.org/uniprot/I1RN64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. http://togogenome.org/gene/229533:FGSG_04287 ^@ http://purl.uniprot.org/uniprot/I1RK93 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Homodimer.|||In the 2nd section; belongs to the EPSP synthase family.|||In the 3rd section; belongs to the shikimate kinase family.|||In the 4th section; belongs to the type-I 3-dehydroquinase family.|||In the C-terminal section; belongs to the shikimate dehydrogenase family.|||In the N-terminal section; belongs to the dehydroquinate synthase family.|||In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. http://togogenome.org/gene/229533:FGSG_01813 ^@ http://purl.uniprot.org/uniprot/I1RDU6 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_02495 ^@ http://purl.uniprot.org/uniprot/I1RFL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07504 ^@ http://purl.uniprot.org/uniprot/I1RTJ6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01627 ^@ http://purl.uniprot.org/uniprot/A0A1I9EZD8|||http://purl.uniprot.org/uniprot/Q4IMD1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated once deposited into chromatin.|||Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (By similarity).|||Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity). http://togogenome.org/gene/229533:FGSG_05503 ^@ http://purl.uniprot.org/uniprot/I1RND0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07886 ^@ http://purl.uniprot.org/uniprot/I1RUJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_09267 ^@ http://purl.uniprot.org/uniprot/I1RY36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_05027 ^@ http://purl.uniprot.org/uniprot/I1RM48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLX9 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_10417 ^@ http://purl.uniprot.org/uniprot/I1S123 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/229533:FGSG_08875 ^@ http://purl.uniprot.org/uniprot/A0A1I9F7Y5|||http://purl.uniprot.org/uniprot/Q4I1N3 ^@ Activity Regulation|||Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically inhibited by 3'-phosphoadenosine 5'-phosphosulfate (PAPS).|||Belongs to the APS kinase family.|||Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.|||Cytoplasm|||Homohexamer. Dimer of trimers.|||In the C-terminal section; belongs to the APS kinase family.|||In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family.|||In the N-terminal section; belongs to the sulfate adenylyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The adenylyl-sulfate kinase (APS kinase) is non-functional. It is involved in allosteric regulation by PAPS. PAPS binding induces a large rotational rearrangement of domains lowering the substrate affinity of the enzyme. http://togogenome.org/gene/229533:FGSG_13865 ^@ http://purl.uniprot.org/uniprot/I1SAI4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_11143 ^@ http://purl.uniprot.org/uniprot/I1S2Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 4 family.|||Secreted http://togogenome.org/gene/229533:FGSG_10253 ^@ http://purl.uniprot.org/uniprot/I1S0M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/229533:FGSG_13587 ^@ http://purl.uniprot.org/uniprot/I1S9Q6 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_09271 ^@ http://purl.uniprot.org/uniprot/I1RY40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_05590 ^@ http://purl.uniprot.org/uniprot/I1RNK7 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_00363 ^@ http://purl.uniprot.org/uniprot/I1RA40 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/229533:FGSG_07419 ^@ http://purl.uniprot.org/uniprot/I1RTB8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_01248 ^@ http://purl.uniprot.org/uniprot/I1RCD8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_00997 ^@ http://purl.uniprot.org/uniprot/I1RBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_11495 ^@ http://purl.uniprot.org/uniprot/I1S3U7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_01730 ^@ http://purl.uniprot.org/uniprot/I1RDM1 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/229533:FGSG_00466 ^@ http://purl.uniprot.org/uniprot/I1RAD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/229533:FGSG_06449 ^@ http://purl.uniprot.org/uniprot/I1RQU9 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_05916 ^@ http://purl.uniprot.org/uniprot/V6RCG5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/229533:FGSG_13708 ^@ http://purl.uniprot.org/uniprot/I1SA27 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/229533:FGSG_06164 ^@ http://purl.uniprot.org/uniprot/I1RQ30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/229533:FGSG_02168 ^@ http://purl.uniprot.org/uniprot/I1RER8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_06313 ^@ http://purl.uniprot.org/uniprot/I1RQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_06846 ^@ http://purl.uniprot.org/uniprot/I1RRV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_05824 ^@ http://purl.uniprot.org/uniprot/I1RP70 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_02083 ^@ http://purl.uniprot.org/uniprot/I1REJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12282 ^@ http://purl.uniprot.org/uniprot/I1S611 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06735 ^@ http://purl.uniprot.org/uniprot/I1RRK7 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 1 family.|||Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/229533:FGSG_10463 ^@ http://purl.uniprot.org/uniprot/I1S165 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Abolishes the production of fusarielins F, G and H.|||Belongs to the LovG family.|||Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes.|||Thioesterase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606). http://togogenome.org/gene/229533:FGSG_09255 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQG2|||http://purl.uniprot.org/uniprot/Q4I0K3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity).|||Membrane http://togogenome.org/gene/229533:FGSG_05561 ^@ http://purl.uniprot.org/uniprot/I1RNI0 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/229533:FGSG_04302 ^@ http://purl.uniprot.org/uniprot/I1RKA5 ^@ Similarity ^@ Belongs to the PheA/TfdB FAD monooxygenase family.|||Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_11257 ^@ http://purl.uniprot.org/uniprot/I1S386 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/229533:FGSG_01805 ^@ http://purl.uniprot.org/uniprot/I1RDT8 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_08977 ^@ http://purl.uniprot.org/uniprot/I1RXB6 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/229533:FGSG_08016 ^@ http://purl.uniprot.org/uniprot/I1RUV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06739 ^@ http://purl.uniprot.org/uniprot/I1RRL0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||May be part of a spliceosome complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_06411 ^@ http://purl.uniprot.org/uniprot/I1RQR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/229533:FGSG_05687 ^@ http://purl.uniprot.org/uniprot/A0A1I9FVW7|||http://purl.uniprot.org/uniprot/Q4IAS1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.|||Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_00828 ^@ http://purl.uniprot.org/uniprot/I1RBB6 ^@ Similarity ^@ Belongs to the asaB hydroxylase/desaturase family. http://togogenome.org/gene/229533:FGSG_08128 ^@ http://purl.uniprot.org/uniprot/I1RV65 ^@ Similarity ^@ Belongs to the SIP5 family. http://togogenome.org/gene/229533:FGSG_09803 ^@ http://purl.uniprot.org/uniprot/I1RZG3 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/229533:FGSG_01394 ^@ http://purl.uniprot.org/uniprot/I1RCR8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/229533:FGSG_04385 ^@ http://purl.uniprot.org/uniprot/I1RKI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_06445 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKF2|||http://purl.uniprot.org/uniprot/I1RQU5 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family.|||Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.|||Expression is under the control of transcription factor XYR1 and highly induced by xylan.|||Secreted http://togogenome.org/gene/229533:FGSG_13444 ^@ http://purl.uniprot.org/uniprot/I1S9B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01010 ^@ http://purl.uniprot.org/uniprot/V6QVD5 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/229533:FGSG_03090 ^@ http://purl.uniprot.org/uniprot/I1RH48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01969 ^@ http://purl.uniprot.org/uniprot/I1RE88 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/229533:FGSG_01892 ^@ http://purl.uniprot.org/uniprot/V6QYC5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_04271 ^@ http://purl.uniprot.org/uniprot/I1RK77 ^@ Similarity ^@ Belongs to the OPI10 family. http://togogenome.org/gene/229533:FGSG_01470 ^@ http://purl.uniprot.org/uniprot/I1RCY5 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/229533:FGSG_00802 ^@ http://purl.uniprot.org/uniprot/I1RB92 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/229533:FGSG_08933 ^@ http://purl.uniprot.org/uniprot/I1RX81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03931 ^@ http://purl.uniprot.org/uniprot/I1RJC0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02207 ^@ http://purl.uniprot.org/uniprot/I1REV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01208 ^@ http://purl.uniprot.org/uniprot/I1RCA5 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/229533:FGSG_01535 ^@ http://purl.uniprot.org/uniprot/I1RD46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/229533:FGSG_10831 ^@ http://purl.uniprot.org/uniprot/I1S247 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/229533:FGSG_13660 ^@ http://purl.uniprot.org/uniprot/I1S9X9 ^@ Disruption Phenotype|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG9 family.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.|||Golgi apparatus membrane|||Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.|||Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236, PubMed:30044782). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236). Required for aerial hyphae development and lipid droplet degradation in response to starvation (PubMed:30044782).|||Phosphorylated by ATG1 (By similarity). ATG1 phosphorylation is required for ATG18 interaction and preautophagosome elongation (By similarity).|||Preautophagosomal structure membrane|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Blocks autophagy (PubMed:30044782). http://togogenome.org/gene/229533:FGSG_08358 ^@ http://purl.uniprot.org/uniprot/I1RVR7 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/229533:FGSG_09681 ^@ http://purl.uniprot.org/uniprot/I1RZ55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_01898 ^@ http://purl.uniprot.org/uniprot/I1RE25 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_04085 ^@ http://purl.uniprot.org/uniprot/I1RJQ5 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/229533:FGSG_03904 ^@ http://purl.uniprot.org/uniprot/I1RJ96 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/229533:FGSG_08887 ^@ http://purl.uniprot.org/uniprot/I1RX38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APC5 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains.|||spindle http://togogenome.org/gene/229533:FGSG_08607 ^@ http://purl.uniprot.org/uniprot/I1RWE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/229533:FGSG_04659 ^@ http://purl.uniprot.org/uniprot/I1RL76 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/229533:FGSG_10961 ^@ http://purl.uniprot.org/uniprot/I1S2G7 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/229533:FGSG_07993 ^@ http://purl.uniprot.org/uniprot/I1RUT8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_07202 ^@ http://purl.uniprot.org/uniprot/I1RSS1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/229533:FGSG_10885 ^@ http://purl.uniprot.org/uniprot/I1S299 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/229533:FGSG_08266 ^@ http://purl.uniprot.org/uniprot/I1RVI8 ^@ Similarity ^@ Belongs to the acetyl-CoA hydrolase/transferase family. http://togogenome.org/gene/229533:FGSG_02757 ^@ http://purl.uniprot.org/uniprot/I1RGA0 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28B subfamily. http://togogenome.org/gene/229533:FGSG_04869 ^@ http://purl.uniprot.org/uniprot/I1RLQ5 ^@ Similarity ^@ Belongs to the tyrosinase family. http://togogenome.org/gene/229533:FGSG_00549 ^@ http://purl.uniprot.org/uniprot/I1RAL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG33 family.|||Involved in the selective degradation of mitochondria via autophagy during starvation and at post-log phase (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Mitochondrion membrane http://togogenome.org/gene/229533:FGSG_05953 ^@ http://purl.uniprot.org/uniprot/V6RBG5 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/229533:FGSG_00188 ^@ http://purl.uniprot.org/uniprot/I1R9N6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01757 ^@ http://purl.uniprot.org/uniprot/V6QXN0 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/229533:FGSG_11828 ^@ http://purl.uniprot.org/uniprot/I1S4R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02463 ^@ http://purl.uniprot.org/uniprot/I1RFI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_10526 ^@ http://purl.uniprot.org/uniprot/I1S1C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFP11/STIP family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09586 ^@ http://purl.uniprot.org/uniprot/I1RYX4 ^@ Function|||Subunit ^@ Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.|||Monomer. http://togogenome.org/gene/229533:FGSG_06384 ^@ http://purl.uniprot.org/uniprot/I1RQN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/229533:FGSG_04543 ^@ http://purl.uniprot.org/uniprot/I1RKX2 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/229533:FGSG_01605 ^@ http://purl.uniprot.org/uniprot/I1RDB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_05625 ^@ http://purl.uniprot.org/uniprot/I1RNP1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/229533:FGSG_05593 ^@ http://purl.uniprot.org/uniprot/I1RNL0 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFA/CMAS family.|||Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. However, C-9 methylation of GlcCers is not essential for the sensitivity of F.graminearum to plant defensins MsDef1 and RsAFP2.|||Membrane|||Produces 65 to 75% nonmethylated and 25 to 35% methylated GlcCers. Exhibits severe growth defects and produces abnormal conidia. Also exhibits drastically reduced disease symptoms in wheat and much-delayed disease symptoms in Arabidopsis thaliana. A double-knockout with its paralog MT1 is not viable. http://togogenome.org/gene/229533:FGSG_11626 ^@ http://purl.uniprot.org/uniprot/A0A1I9FPH7|||http://purl.uniprot.org/uniprot/Q4HTT2 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).|||Belongs to the histone H2B family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).|||Nucleus|||Phosphorylated to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).|||Sumoylation to form H2BK6su or H2BK7su, and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-8; H2BK6su = sumoylated Lys-8; H2BK7ac = acetylated Lys-9; H2BK7su = sumoylated Lys-9; H2BS10ph = phosphorylated Ser-12; H2BK11ac = acetylated Lys-13; H2BK16ac = acetylated Lys-24; H2BK16su = sumoylated Lys-24; H2BK17su = sumoylated Lys-25; H2BK123ub1 = monoubiquitinated Lys-131. http://togogenome.org/gene/229533:FGSG_03889 ^@ http://purl.uniprot.org/uniprot/I1RJ81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00296 ^@ http://purl.uniprot.org/uniprot/V6QU65 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/229533:FGSG_09128 ^@ http://purl.uniprot.org/uniprot/I1RXQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03733 ^@ http://purl.uniprot.org/uniprot/I1RIT9 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_09512 ^@ http://purl.uniprot.org/uniprot/I1RYQ4 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_05801 ^@ http://purl.uniprot.org/uniprot/I1RP49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05315 ^@ http://purl.uniprot.org/uniprot/I1RMW3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_02470 ^@ http://purl.uniprot.org/uniprot/I1RFJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_04127 ^@ http://purl.uniprot.org/uniprot/I1RJU5 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/229533:FGSG_10840 ^@ http://purl.uniprot.org/uniprot/I1S256 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/229533:FGSG_05827 ^@ http://purl.uniprot.org/uniprot/I1RP73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12187 ^@ http://purl.uniprot.org/uniprot/I1S5R6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/229533:FGSG_06798 ^@ http://purl.uniprot.org/uniprot/Q4I7L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.|||Cytoplasm|||Nucleus|||Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. http://togogenome.org/gene/229533:FGSG_10822 ^@ http://purl.uniprot.org/uniprot/I1S238 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/229533:FGSG_08014 ^@ http://purl.uniprot.org/uniprot/I1RUV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01336 ^@ http://purl.uniprot.org/uniprot/I1RCL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus|||ORC is composed of six subunits. http://togogenome.org/gene/229533:FGSG_05487 ^@ http://purl.uniprot.org/uniprot/I1RNB7 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/229533:FGSG_09500 ^@ http://purl.uniprot.org/uniprot/I1RYP2 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/229533:FGSG_08469 ^@ http://purl.uniprot.org/uniprot/I1RW17 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/229533:FGSG_09565 ^@ http://purl.uniprot.org/uniprot/I1RYV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07034 ^@ http://purl.uniprot.org/uniprot/I1RSC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11484 ^@ http://purl.uniprot.org/uniprot/I1S3T6 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03443 ^@ http://purl.uniprot.org/uniprot/I1RI22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02029 ^@ http://purl.uniprot.org/uniprot/I1REE1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_09996 ^@ http://purl.uniprot.org/uniprot/I1RZY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_01343 ^@ http://purl.uniprot.org/uniprot/I1RCM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_09628 ^@ http://purl.uniprot.org/uniprot/A0A1I9FMD6|||http://purl.uniprot.org/uniprot/Q4HZI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diphthine synthase family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/229533:FGSG_06335 ^@ http://purl.uniprot.org/uniprot/I1RQJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_12746 ^@ http://purl.uniprot.org/uniprot/I1S7C3 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/229533:FGSG_00570 ^@ http://purl.uniprot.org/uniprot/I1RAN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09011 ^@ http://purl.uniprot.org/uniprot/I1RXE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08551 ^@ http://purl.uniprot.org/uniprot/I1RW90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/229533:FGSG_00588 ^@ http://purl.uniprot.org/uniprot/I1RAQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_04126 ^@ http://purl.uniprot.org/uniprot/I1RJU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uricase family.|||Catalyzes the oxidation of uric acid to 5-hydroxyisourate, which is further processed to form (S)-allantoin.|||Peroxisome http://togogenome.org/gene/229533:FGSG_09376 ^@ http://purl.uniprot.org/uniprot/I1RYD1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08803 ^@ http://purl.uniprot.org/uniprot/I1RWW7 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/229533:FGSG_05696 ^@ http://purl.uniprot.org/uniprot/I1RNV4 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_05127 ^@ http://purl.uniprot.org/uniprot/I1RMD8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08845 ^@ http://purl.uniprot.org/uniprot/I1RX04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_03968 ^@ http://purl.uniprot.org/uniprot/I1RJF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_04181 ^@ http://purl.uniprot.org/uniprot/I1RJZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_05607 ^@ http://purl.uniprot.org/uniprot/I1RNM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_12703 ^@ http://purl.uniprot.org/uniprot/I1S780 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07375 ^@ http://purl.uniprot.org/uniprot/I1RT76 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/229533:FGSG_03475 ^@ http://purl.uniprot.org/uniprot/I1RI50 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_06165 ^@ http://purl.uniprot.org/uniprot/I1RQ31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_10257 ^@ http://purl.uniprot.org/uniprot/I1S0M4 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_07543 ^@ http://purl.uniprot.org/uniprot/I1RTN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00494 ^@ http://purl.uniprot.org/uniprot/I1RAG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00023 ^@ http://purl.uniprot.org/uniprot/I1R994 ^@ Similarity ^@ Belongs to the germin family. http://togogenome.org/gene/229533:FGSG_06562 ^@ http://purl.uniprot.org/uniprot/I1RR53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_10896 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQL8|||http://purl.uniprot.org/uniprot/Q4HVW2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.|||Component of pre-60S ribosomal complexes.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_10005 ^@ http://purl.uniprot.org/uniprot/V6RXE7 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/229533:FGSG_01526 ^@ http://purl.uniprot.org/uniprot/I1RD37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01440 ^@ http://purl.uniprot.org/uniprot/I1RCV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Membrane http://togogenome.org/gene/229533:FGSG_11282 ^@ http://purl.uniprot.org/uniprot/I1S3A7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_05523 ^@ http://purl.uniprot.org/uniprot/I1RNE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/229533:FGSG_00781 ^@ http://purl.uniprot.org/uniprot/I1RB74 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/229533:FGSG_12296 ^@ http://purl.uniprot.org/uniprot/I1S625 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fluoride exporter Fluc/FEX family.|||Fluoride channel required for the rapid expulsion of cytoplasmic fluoride.|||Membrane http://togogenome.org/gene/229533:FGSG_02720 ^@ http://purl.uniprot.org/uniprot/I1RG69 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/229533:FGSG_12193 ^@ http://purl.uniprot.org/uniprot/I1S5S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/229533:FGSG_10276 ^@ http://purl.uniprot.org/uniprot/I1S0P0 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/229533:FGSG_11044 ^@ http://purl.uniprot.org/uniprot/I1S2P4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_10680 ^@ http://purl.uniprot.org/uniprot/I1S1R5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00861 ^@ http://purl.uniprot.org/uniprot/I1RBE4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/229533:FGSG_03673 ^@ http://purl.uniprot.org/uniprot/I1RIN3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_08924 ^@ http://purl.uniprot.org/uniprot/I1RX74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01817 ^@ http://purl.uniprot.org/uniprot/I1RDV0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06007 ^@ http://purl.uniprot.org/uniprot/I1RPN2 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/229533:FGSG_03541 ^@ http://purl.uniprot.org/uniprot/I1RIB0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01302 ^@ http://purl.uniprot.org/uniprot/I1RCI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03467 ^@ http://purl.uniprot.org/uniprot/I1RI44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M36 family.|||Secreted http://togogenome.org/gene/229533:FGSG_10992 ^@ http://purl.uniprot.org/uniprot/I1S2J6 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the polysaccharide deacetylase family.|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Leads to reduced virulence and produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.|||Peptidoglycan deacetylase-like protein; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable). http://togogenome.org/gene/229533:FGSG_01098 ^@ http://purl.uniprot.org/uniprot/I1RBZ9 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/229533:FGSG_04584 ^@ http://purl.uniprot.org/uniprot/I1RL09 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/229533:FGSG_10222 ^@ http://purl.uniprot.org/uniprot/A0A1I9F4Y5|||http://purl.uniprot.org/uniprot/Q4HXT6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0057 (PMP3) family.|||Cell membrane|||Plays a role in the regulation of membrane potential. Could mediate a proton leak (By similarity). http://togogenome.org/gene/229533:FGSG_00475 ^@ http://purl.uniprot.org/uniprot/I1RAE8 ^@ Function|||Similarity ^@ Belongs to the NARF family.|||Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins. http://togogenome.org/gene/229533:FGSG_03114 ^@ http://purl.uniprot.org/uniprot/I1RH70 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28B subfamily. http://togogenome.org/gene/229533:FGSG_04945 ^@ http://purl.uniprot.org/uniprot/V6RG04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06000 ^@ http://purl.uniprot.org/uniprot/I1RPM5 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/229533:FGSG_04722 ^@ http://purl.uniprot.org/uniprot/I1RLC9 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_05658 ^@ http://purl.uniprot.org/uniprot/I1RNS1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/229533:FGSG_04485 ^@ http://purl.uniprot.org/uniprot/I1RKR9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/229533:FGSG_03700 ^@ http://purl.uniprot.org/uniprot/I1RIQ8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_04589 ^@ http://purl.uniprot.org/uniprot/I1RL12 ^@ Biotechnology|||Function|||Similarity ^@ Belongs to the methyltransferase superfamily.|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||S-adenosyl-L-methionine-dependent methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_09052 ^@ http://purl.uniprot.org/uniprot/I1RXI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02324 ^@ http://purl.uniprot.org/uniprot/I1RF58 ^@ Disruption Phenotype|||Domain|||Function|||Induction ^@ Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721). Expression is negatively regulated by the MAPK-mediated osmotic stress-signaling pathway (PubMed:17897620). Expression is also regulated by the CID1 cyclin C-like protein (PubMed:19909822).|||Leads to a albinos phanotype and affects conidiation (PubMed:15811992, PubMed:16278459, PubMed:15809006, PubMed:15780665).|||Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (By similarity).|||Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:16278459, PubMed:15809006, PubMed:15780665, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||The C-terminal region is involved in Claisen-type cyclization of the second ring of naphthopyrone. http://togogenome.org/gene/229533:FGSG_01794 ^@ http://purl.uniprot.org/uniprot/I1RDS8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00629 ^@ http://purl.uniprot.org/uniprot/I1RAU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/229533:FGSG_08038 ^@ http://purl.uniprot.org/uniprot/I1RUX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00361 ^@ http://purl.uniprot.org/uniprot/I1RA38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09163 ^@ http://purl.uniprot.org/uniprot/I1RXT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09557 ^@ http://purl.uniprot.org/uniprot/A0A1I9FL55|||http://purl.uniprot.org/uniprot/Q4HZQ1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||Cytoplasm|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death. http://togogenome.org/gene/229533:FGSG_09076 ^@ http://purl.uniprot.org/uniprot/I1RXK5 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/229533:FGSG_07954 ^@ http://purl.uniprot.org/uniprot/A0A1I9FLU5|||http://purl.uniprot.org/uniprot/Q4I4A4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Golgi apparatus membrane|||Membrane|||Probable serine protease.|||cis-Golgi network membrane http://togogenome.org/gene/229533:FGSG_03683 ^@ http://purl.uniprot.org/uniprot/I1RIP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00340 ^@ http://purl.uniprot.org/uniprot/A0A1I9EV20|||http://purl.uniprot.org/uniprot/Q4IR18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Clp1 family. NOL9/GRC3 subfamily.|||Polynucleotide 5'-kinase involved in rRNA processing.|||nucleolus http://togogenome.org/gene/229533:FGSG_01533 ^@ http://purl.uniprot.org/uniprot/I1RD44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Membrane|||Probably involved in transport through the plasma membrane. http://togogenome.org/gene/229533:FGSG_04054 ^@ http://purl.uniprot.org/uniprot/I1RJM9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_04723 ^@ http://purl.uniprot.org/uniprot/I1RLD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07924 ^@ http://purl.uniprot.org/uniprot/I1RUM5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01912 ^@ http://purl.uniprot.org/uniprot/I1RE39 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08352 ^@ http://purl.uniprot.org/uniprot/I1RVR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvP family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/229533:FGSG_00655 ^@ http://purl.uniprot.org/uniprot/V6QU63 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_01360 ^@ http://purl.uniprot.org/uniprot/V6QWP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_07200 ^@ http://purl.uniprot.org/uniprot/I1RSR9 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/229533:FGSG_05053 ^@ http://purl.uniprot.org/uniprot/I1RM70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06636 ^@ http://purl.uniprot.org/uniprot/I1RRB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane http://togogenome.org/gene/229533:FGSG_07122 ^@ http://purl.uniprot.org/uniprot/I1RSK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01948 ^@ http://purl.uniprot.org/uniprot/I1RE71 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_04037 ^@ http://purl.uniprot.org/uniprot/I1RJL2 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/229533:FGSG_06011 ^@ http://purl.uniprot.org/uniprot/Q4I9U7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH3 family.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).|||The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. http://togogenome.org/gene/229533:FGSG_05705 ^@ http://purl.uniprot.org/uniprot/I1RNW3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04863 ^@ http://purl.uniprot.org/uniprot/I1RLP9 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_07120 ^@ http://purl.uniprot.org/uniprot/I1RSJ9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||GTPase-activating protein for the ADP ribosylation factor family. http://togogenome.org/gene/229533:FGSG_04858 ^@ http://purl.uniprot.org/uniprot/I1RLP4 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/229533:FGSG_05747 ^@ http://purl.uniprot.org/uniprot/I1RP00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09815 ^@ http://purl.uniprot.org/uniprot/I1RZH4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/229533:FGSG_01236 ^@ http://purl.uniprot.org/uniprot/I1RCD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00683 ^@ http://purl.uniprot.org/uniprot/I1RAY7 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_08960 ^@ http://purl.uniprot.org/uniprot/I1RXA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the kinesin light chain family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_00543 ^@ http://purl.uniprot.org/uniprot/I1RAL2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/229533:FGSG_01760 ^@ http://purl.uniprot.org/uniprot/I1RDP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00495 ^@ http://purl.uniprot.org/uniprot/I1RAG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_05505 ^@ http://purl.uniprot.org/uniprot/I1RND2 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/229533:FGSG_00998 ^@ http://purl.uniprot.org/uniprot/I1RBR2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_09438 ^@ http://purl.uniprot.org/uniprot/I1RYI5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/229533:FGSG_08540 ^@ http://purl.uniprot.org/uniprot/I1RW79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07121 ^@ http://purl.uniprot.org/uniprot/I1RSK0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/229533:FGSG_12342 ^@ http://purl.uniprot.org/uniprot/I1S671 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00554 ^@ http://purl.uniprot.org/uniprot/I1RAM2 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/229533:FGSG_04683 ^@ http://purl.uniprot.org/uniprot/I1RL97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02000 ^@ http://purl.uniprot.org/uniprot/I1REB4 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_05052 ^@ http://purl.uniprot.org/uniprot/I1RM69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_05263 ^@ http://purl.uniprot.org/uniprot/I1RMR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/229533:FGSG_01449 ^@ http://purl.uniprot.org/uniprot/I1RCW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_00536 ^@ http://purl.uniprot.org/uniprot/I1RAK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02544 ^@ http://purl.uniprot.org/uniprot/I1RFQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_09817 ^@ http://purl.uniprot.org/uniprot/I1RZH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_06577 ^@ http://purl.uniprot.org/uniprot/I1RR65 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/229533:FGSG_00583 ^@ http://purl.uniprot.org/uniprot/I1RAP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/229533:FGSG_10313 ^@ http://purl.uniprot.org/uniprot/I1S0S6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/229533:FGSG_09351 ^@ http://purl.uniprot.org/uniprot/I1RYA9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_03168 ^@ http://purl.uniprot.org/uniprot/I1RHC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08660 ^@ http://purl.uniprot.org/uniprot/Q4I298 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.|||Homopentamer. Forms homooligomers. Interacts with MFM1.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11622 ^@ http://purl.uniprot.org/uniprot/I1S461 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM3 family.|||Nucleus|||Plays an important role in the control of DNA replication and the maintenance of replication fork stability. http://togogenome.org/gene/229533:FGSG_07438 ^@ http://purl.uniprot.org/uniprot/I1RTD5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/229533:FGSG_00915 ^@ http://purl.uniprot.org/uniprot/I1RBJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02595 ^@ http://purl.uniprot.org/uniprot/I1RFV4 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/229533:FGSG_04547 ^@ http://purl.uniprot.org/uniprot/I1RKX6 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_13569 ^@ http://purl.uniprot.org/uniprot/I1S9N8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03966 ^@ http://purl.uniprot.org/uniprot/I1RJF0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08873 ^@ http://purl.uniprot.org/uniprot/I1RX27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_03601 ^@ http://purl.uniprot.org/uniprot/I1RIG9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_09772 ^@ http://purl.uniprot.org/uniprot/I1RZD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00048 ^@ http://purl.uniprot.org/uniprot/I1R9B5 ^@ Cofactor|||Function|||Similarity ^@ 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).|||Belongs to the iron/ascorbate-dependent oxidoreductase family.|||Binds 1 Fe(2+) ion per subunit. http://togogenome.org/gene/229533:FGSG_04461 ^@ http://purl.uniprot.org/uniprot/I1RKP8 ^@ Similarity ^@ Belongs to the paxB family. http://togogenome.org/gene/229533:FGSG_02247 ^@ http://purl.uniprot.org/uniprot/I1REY8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_04854 ^@ http://purl.uniprot.org/uniprot/I1RLP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_02343 ^@ http://purl.uniprot.org/uniprot/I1RF77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02139 ^@ http://purl.uniprot.org/uniprot/I1REP5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_02130 ^@ http://purl.uniprot.org/uniprot/I1REN7 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/229533:FGSG_09156 ^@ http://purl.uniprot.org/uniprot/I1RXT1 ^@ Similarity ^@ Belongs to the peptidase S8 family. Furin subfamily. http://togogenome.org/gene/229533:FGSG_08736 ^@ http://purl.uniprot.org/uniprot/I1RWQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Cytoplasm|||Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.|||Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.|||Mitochondrion|||The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities. http://togogenome.org/gene/229533:FGSG_03486 ^@ http://purl.uniprot.org/uniprot/I1RI61 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/229533:FGSG_07634 ^@ http://purl.uniprot.org/uniprot/I1RTW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05140 ^@ http://purl.uniprot.org/uniprot/I1RMF1 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06694 ^@ http://purl.uniprot.org/uniprot/I1RRH3 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/229533:FGSG_01169 ^@ http://purl.uniprot.org/uniprot/I1RC66 ^@ Similarity|||Subunit ^@ Belongs to the SIL1 family.|||Interacts with KAR2. http://togogenome.org/gene/229533:FGSG_03121 ^@ http://purl.uniprot.org/uniprot/I1RH76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_03292 ^@ http://purl.uniprot.org/uniprot/I1RHN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06089 ^@ http://purl.uniprot.org/uniprot/I1RPV7 ^@ Function|||Subunit ^@ Associates with DNA double-strand breaks.|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. http://togogenome.org/gene/229533:FGSG_10660 ^@ http://purl.uniprot.org/uniprot/I1S1P9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11643 ^@ http://purl.uniprot.org/uniprot/I1S476 ^@ Function|||Similarity ^@ Belongs to the endosulfine family.|||Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. http://togogenome.org/gene/229533:FGSG_07057 ^@ http://purl.uniprot.org/uniprot/V6RH07 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_04434 ^@ http://purl.uniprot.org/uniprot/I1RKM3 ^@ Similarity ^@ Belongs to the peroxidase family. http://togogenome.org/gene/229533:FGSG_10938 ^@ http://purl.uniprot.org/uniprot/I1S2E6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00161 ^@ http://purl.uniprot.org/uniprot/I1R9L4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06703 ^@ http://purl.uniprot.org/uniprot/I1RRI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_01724 ^@ http://purl.uniprot.org/uniprot/I1RDL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10245 ^@ http://purl.uniprot.org/uniprot/I1S0L3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/229533:FGSG_05406 ^@ http://purl.uniprot.org/uniprot/I1RN43 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/229533:FGSG_11486 ^@ http://purl.uniprot.org/uniprot/I1S3T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08794 ^@ http://purl.uniprot.org/uniprot/I1RWV8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00639 ^@ http://purl.uniprot.org/uniprot/A0A1I9EW63|||http://purl.uniprot.org/uniprot/Q5I2J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_07017 ^@ http://purl.uniprot.org/uniprot/I1RSA3 ^@ Function|||Similarity ^@ Belongs to the dihydroxyacetone kinase (DAK) family.|||Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. http://togogenome.org/gene/229533:FGSG_05200 ^@ http://purl.uniprot.org/uniprot/I1RMK9 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy (By similarity). Required for both micropexophagy and macropexophagy, but not for the cytoplasm to vacuole transport (Cvt) or autophagy pathways (By similarity). Required for functional micropexophagic apparatus (MIPA) and relocation of ATG11 to the peroxisome-sequestering arms of the vacuole (By similarity). Binds palmytoyl-CoA but not oleyl-CoA (By similarity).|||Belongs to the ATG37 family.|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).|||Peroxisome membrane http://togogenome.org/gene/229533:FGSG_01643 ^@ http://purl.uniprot.org/uniprot/I1RDE7 ^@ Similarity ^@ Belongs to the chorismate synthase family. http://togogenome.org/gene/229533:FGSG_05604 ^@ http://purl.uniprot.org/uniprot/I1RNM1 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/229533:FGSG_06406 ^@ http://purl.uniprot.org/uniprot/I1RQQ8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/229533:FGSG_03774 ^@ http://purl.uniprot.org/uniprot/I1RIX7 ^@ Similarity ^@ Belongs to the asaB hydroxylase/desaturase family. http://togogenome.org/gene/229533:FGSG_02807 ^@ http://purl.uniprot.org/uniprot/I1RGE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/229533:FGSG_13650 ^@ http://purl.uniprot.org/uniprot/I1S9W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00372 ^@ http://purl.uniprot.org/uniprot/I1RA48 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/229533:FGSG_07683 ^@ http://purl.uniprot.org/uniprot/V6RJ29 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02460 ^@ http://purl.uniprot.org/uniprot/I1RFI3 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. http://togogenome.org/gene/229533:FGSG_02784 ^@ http://purl.uniprot.org/uniprot/I1RGC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool.|||Belongs to the complex I LYR family. MZM1 subfamily.|||Interacts with RIP1.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_03693 ^@ http://purl.uniprot.org/uniprot/I1RIQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_10950 ^@ http://purl.uniprot.org/uniprot/I1S2F7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_10659 ^@ http://purl.uniprot.org/uniprot/I1S1P8 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/229533:FGSG_09229 ^@ http://purl.uniprot.org/uniprot/A0A1I9FI97|||http://purl.uniprot.org/uniprot/Q4I0M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. http://togogenome.org/gene/229533:FGSG_02797 ^@ http://purl.uniprot.org/uniprot/A0A1I9FAQ5|||http://purl.uniprot.org/uniprot/Q4IJ11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWS1 family.|||Nucleus|||Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity). http://togogenome.org/gene/229533:FGSG_05981 ^@ http://purl.uniprot.org/uniprot/I1RPK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07873 ^@ http://purl.uniprot.org/uniprot/I1RUI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12142 ^@ http://purl.uniprot.org/uniprot/I1S5M1 ^@ Cofactor|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||extracellular space http://togogenome.org/gene/229533:FGSG_05346 ^@ http://purl.uniprot.org/uniprot/I1RMZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09432 ^@ http://purl.uniprot.org/uniprot/I1RYH9 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/229533:FGSG_00504 ^@ http://purl.uniprot.org/uniprot/I1RAH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06661 ^@ http://purl.uniprot.org/uniprot/I1RRE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RIX1/PELP1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10445 ^@ http://purl.uniprot.org/uniprot/I1S148 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/229533:FGSG_03928 ^@ http://purl.uniprot.org/uniprot/I1RJB7 ^@ Similarity ^@ Belongs to the PrpF family. http://togogenome.org/gene/229533:FGSG_09666 ^@ http://purl.uniprot.org/uniprot/I1RZ42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_05305 ^@ http://purl.uniprot.org/uniprot/I1RMV5 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/229533:FGSG_00491 ^@ http://purl.uniprot.org/uniprot/V6QUV7 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/229533:FGSG_08443 ^@ http://purl.uniprot.org/uniprot/I1RVZ3 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/229533:FGSG_11891 ^@ http://purl.uniprot.org/uniprot/I1S4X3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01037 ^@ http://purl.uniprot.org/uniprot/V6QVM5 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/229533:FGSG_07115 ^@ http://purl.uniprot.org/uniprot/I1RSJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/229533:FGSG_09869 ^@ http://purl.uniprot.org/uniprot/I1RZM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09456 ^@ http://purl.uniprot.org/uniprot/I1RYK0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/229533:FGSG_06235 ^@ http://purl.uniprot.org/uniprot/V6RK66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05269 ^@ http://purl.uniprot.org/uniprot/I1RMS2 ^@ Similarity ^@ Belongs to the XPC family. http://togogenome.org/gene/229533:FGSG_07909 ^@ http://purl.uniprot.org/uniprot/I1RUL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05589 ^@ http://purl.uniprot.org/uniprot/I1RNK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07368 ^@ http://purl.uniprot.org/uniprot/I1RT69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04828 ^@ http://purl.uniprot.org/uniprot/I1RLM2 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/229533:FGSG_12440 ^@ http://purl.uniprot.org/uniprot/I1S6G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05438 ^@ http://purl.uniprot.org/uniprot/I1RN72 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/229533:FGSG_05385 ^@ http://purl.uniprot.org/uniprot/I1RN24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05903 ^@ http://purl.uniprot.org/uniprot/I1RPD6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/229533:FGSG_03417 ^@ http://purl.uniprot.org/uniprot/I1RHZ8 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_09335 ^@ http://purl.uniprot.org/uniprot/I1RY94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11709 ^@ http://purl.uniprot.org/uniprot/I1S4E2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01308 ^@ http://purl.uniprot.org/uniprot/I1RCJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPR3 family.|||Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_02890 ^@ http://purl.uniprot.org/uniprot/I1RGL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_03979 ^@ http://purl.uniprot.org/uniprot/I1RJG2 ^@ Function|||Subunit ^@ Inclusion body (IB) resident protein that interacts strongly with lipid droplet (LD) proteins. Involved in LD-mediated IB clearing after protein folding stress, probably by enabling access to the IBs of an LD-stored soluble sterol derivative that acts as chaperone in inclusion clearing.|||Interacts with lipid droplet proteins. http://togogenome.org/gene/229533:FGSG_09100 ^@ http://purl.uniprot.org/uniprot/I1RXM6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Homotetramer.|||Hydrolyzes deoxynucleoside triphosphates (dNTPs) to the corresponding nucleoside monophosphates. Has a strong preference for dCTP and its analogs including 5-iodo-dCTP and 5-methyl-dCTP for which it may even have a higher efficiency. May protect DNA or RNA against the incorporation of these genotoxic nucleotide analogs through their catabolism.|||cytosol http://togogenome.org/gene/229533:FGSG_09574 ^@ http://purl.uniprot.org/uniprot/I1RYW3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. http://togogenome.org/gene/229533:FGSG_02606 ^@ http://purl.uniprot.org/uniprot/A0A1I9F284|||http://purl.uniprot.org/uniprot/Q4IJK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).|||Mitochondrion|||Part of the mitochondrial small ribosomal subunit. http://togogenome.org/gene/229533:FGSG_02970 ^@ http://purl.uniprot.org/uniprot/I1RGU3 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/229533:FGSG_02163 ^@ http://purl.uniprot.org/uniprot/I1RER5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09162 ^@ http://purl.uniprot.org/uniprot/V6RUT5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/229533:FGSG_06279 ^@ http://purl.uniprot.org/uniprot/I1RQD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09311 ^@ http://purl.uniprot.org/uniprot/V6RN31 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/229533:FGSG_09444 ^@ http://purl.uniprot.org/uniprot/V6RN69 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_10747 ^@ http://purl.uniprot.org/uniprot/V6RU25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05599 ^@ http://purl.uniprot.org/uniprot/I1RNL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MET18/MMS19 family.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus http://togogenome.org/gene/229533:FGSG_00819 ^@ http://purl.uniprot.org/uniprot/A0A1I9EWN3|||http://purl.uniprot.org/uniprot/Q4IPN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/229533:FGSG_03323 ^@ http://purl.uniprot.org/uniprot/I1RHR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03278 ^@ http://purl.uniprot.org/uniprot/I1RHL9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/229533:FGSG_10037 ^@ http://purl.uniprot.org/uniprot/A0A1I9F4B7|||http://purl.uniprot.org/uniprot/Q4HYC1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus|||This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).|||telomere http://togogenome.org/gene/229533:FGSG_05094 ^@ http://purl.uniprot.org/uniprot/I1RMA7 ^@ Similarity ^@ Belongs to the IST1 family. http://togogenome.org/gene/229533:FGSG_10290 ^@ http://purl.uniprot.org/uniprot/I1S0Q4 ^@ Cofactor|||Function|||Similarity ^@ Adenine glycosylase active on G-A mispairs.|||Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/229533:FGSG_12094 ^@ http://purl.uniprot.org/uniprot/I1S5H3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02109 ^@ http://purl.uniprot.org/uniprot/I1REL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_06697 ^@ http://purl.uniprot.org/uniprot/I1RRH6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_07810 ^@ http://purl.uniprot.org/uniprot/I1RUC2 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_03547 ^@ http://purl.uniprot.org/uniprot/I1RIB6 ^@ Caution|||Similarity ^@ Belongs to the cytochrome b5 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_04554 ^@ http://purl.uniprot.org/uniprot/I1RKY2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/229533:FGSG_01377 ^@ http://purl.uniprot.org/uniprot/I1RCQ3 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/229533:FGSG_09879 ^@ http://purl.uniprot.org/uniprot/I1RZM9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal cytochrome c oxidase subunit 7a family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_02308 ^@ http://purl.uniprot.org/uniprot/I1RF42 ^@ Similarity ^@ Belongs to the DSD1 family. http://togogenome.org/gene/229533:FGSG_00841 ^@ http://purl.uniprot.org/uniprot/I1RBC5 ^@ Function|||Subcellular Location Annotation ^@ RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_10446 ^@ http://purl.uniprot.org/uniprot/I1S149 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/229533:FGSG_10909 ^@ http://purl.uniprot.org/uniprot/I1S2C1 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/229533:FGSG_07701 ^@ http://purl.uniprot.org/uniprot/I1RU25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08282 ^@ http://purl.uniprot.org/uniprot/I1RVK2 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_08522 ^@ http://purl.uniprot.org/uniprot/I1RW65 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/229533:FGSG_13007 ^@ http://purl.uniprot.org/uniprot/I1S831 ^@ Similarity ^@ Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_04204 ^@ http://purl.uniprot.org/uniprot/I1RK17 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_01184 ^@ http://purl.uniprot.org/uniprot/I1RC81 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/229533:FGSG_05064 ^@ http://purl.uniprot.org/uniprot/I1RM81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYSTM1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_10269 ^@ http://purl.uniprot.org/uniprot/I1S0N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_10933 ^@ http://purl.uniprot.org/uniprot/I1S2E1 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/229533:FGSG_03646 ^@ http://purl.uniprot.org/uniprot/I1RIK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03708 ^@ http://purl.uniprot.org/uniprot/I1RIR5 ^@ Similarity ^@ Belongs to the chloroperoxidase family. http://togogenome.org/gene/229533:FGSG_10713 ^@ http://purl.uniprot.org/uniprot/I1S1U3 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_07043 ^@ http://purl.uniprot.org/uniprot/I1RSC7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/229533:FGSG_05227 ^@ http://purl.uniprot.org/uniprot/I1RMN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06786 ^@ http://purl.uniprot.org/uniprot/I1RRQ1 ^@ Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily. http://togogenome.org/gene/229533:FGSG_05272 ^@ http://purl.uniprot.org/uniprot/I1RMS5 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/229533:FGSG_05210 ^@ http://purl.uniprot.org/uniprot/I1RML8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/229533:FGSG_07048 ^@ http://purl.uniprot.org/uniprot/V6RMW6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/229533:FGSG_01167 ^@ http://purl.uniprot.org/uniprot/I1RC64 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/229533:FGSG_01332 ^@ http://purl.uniprot.org/uniprot/I1RCL3 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/229533:FGSG_01816 ^@ http://purl.uniprot.org/uniprot/I1RDU9 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_05251 ^@ http://purl.uniprot.org/uniprot/I1RMQ6 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/229533:FGSG_10825 ^@ http://purl.uniprot.org/uniprot/I1S241 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/229533:FGSG_06687 ^@ http://purl.uniprot.org/uniprot/A0A1I9FPZ1|||http://purl.uniprot.org/uniprot/Q4I7X1 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for 3'-end cleavage and polyadenylation of pre-mRNAs.|||Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity). http://togogenome.org/gene/229533:FGSG_06920 ^@ http://purl.uniprot.org/uniprot/I1RS16 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/229533:FGSG_10906 ^@ http://purl.uniprot.org/uniprot/I1S2B8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/229533:FGSG_11205 ^@ http://purl.uniprot.org/uniprot/I1S341 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cerato-platanin family.|||Secreted http://togogenome.org/gene/229533:FGSG_09852 ^@ http://purl.uniprot.org/uniprot/I1RZK5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/229533:FGSG_06586 ^@ http://purl.uniprot.org/uniprot/I1RR72 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/229533:FGSG_01765 ^@ http://purl.uniprot.org/uniprot/I1RDQ1 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_06553 ^@ http://purl.uniprot.org/uniprot/I1RR44 ^@ Similarity ^@ Belongs to the XFP family. http://togogenome.org/gene/229533:FGSG_09483 ^@ http://purl.uniprot.org/uniprot/I1RYM6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03063 ^@ http://purl.uniprot.org/uniprot/V6R6H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_02181 ^@ http://purl.uniprot.org/uniprot/I1RET0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_00697 ^@ http://purl.uniprot.org/uniprot/I1RB00 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/229533:FGSG_01672 ^@ http://purl.uniprot.org/uniprot/I1RDH6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NMT1/THI5 family.|||Homodimer.|||Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. http://togogenome.org/gene/229533:FGSG_00288 ^@ http://purl.uniprot.org/uniprot/I1R9X4 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/229533:FGSG_02215 ^@ http://purl.uniprot.org/uniprot/I1REW1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09647 ^@ http://purl.uniprot.org/uniprot/I1RZ29 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_10138 ^@ http://purl.uniprot.org/uniprot/A0A1I9F3N8|||http://purl.uniprot.org/uniprot/Q4HY20 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04886 ^@ http://purl.uniprot.org/uniprot/V6R9Z3 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/229533:FGSG_02645 ^@ http://purl.uniprot.org/uniprot/I1RFZ7 ^@ Similarity ^@ Belongs to the peptidase C2 family. PalB/RIM13 subfamily. http://togogenome.org/gene/229533:FGSG_01467 ^@ http://purl.uniprot.org/uniprot/I1RCY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09332 ^@ http://purl.uniprot.org/uniprot/I1RY92 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/229533:FGSG_04612 ^@ http://purl.uniprot.org/uniprot/I1RL32 ^@ Function|||Similarity ^@ Belongs to the POA1 family.|||Highly specific phosphatase involved in the metabolism of ADP-ribose 1''-phosphate (Appr1p) which is produced as a consequence of tRNA splicing. http://togogenome.org/gene/229533:FGSG_11122 ^@ http://purl.uniprot.org/uniprot/I1S2W6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06886 ^@ http://purl.uniprot.org/uniprot/I1RRY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/229533:FGSG_00646 ^@ http://purl.uniprot.org/uniprot/I1RAV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10739 ^@ http://purl.uniprot.org/uniprot/V6RVJ3 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_08851 ^@ http://purl.uniprot.org/uniprot/I1RX10 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/229533:FGSG_02854 ^@ http://purl.uniprot.org/uniprot/I1RGI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08716 ^@ http://purl.uniprot.org/uniprot/I1RWN8 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/229533:FGSG_00071 ^@ http://purl.uniprot.org/uniprot/I1R9D6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_06776 ^@ http://purl.uniprot.org/uniprot/I1RRP3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/229533:FGSG_08039 ^@ http://purl.uniprot.org/uniprot/I1RUY0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_03891 ^@ http://purl.uniprot.org/uniprot/I1RJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06201 ^@ http://purl.uniprot.org/uniprot/I1RQ63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02918 ^@ http://purl.uniprot.org/uniprot/I1RGP5 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_09975 ^@ http://purl.uniprot.org/uniprot/I1RZW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10789 ^@ http://purl.uniprot.org/uniprot/I1S209 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FG10789.1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_09241 ^@ http://purl.uniprot.org/uniprot/I1RY13 ^@ Similarity ^@ Belongs to the UPL family. K-HECT subfamily. http://togogenome.org/gene/229533:FGSG_03747 ^@ http://purl.uniprot.org/uniprot/I1RIV2 ^@ Disruption Phenotype|||Domain|||Function|||Similarity ^@ Belongs to the NRP synthetase family.|||Leads to increased sensitivity to oxidative stress and raduces the virulence toward wheat plants (PubMed:17056706).|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). NPS6 contains a degenerate A domain (dA) in the second module and has the following architecture: A-T-C-dA-T-T-C (PubMed:17056706).|||Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875). http://togogenome.org/gene/229533:FGSG_09549 ^@ http://purl.uniprot.org/uniprot/I1RYU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/229533:FGSG_07266 ^@ http://purl.uniprot.org/uniprot/I1RSX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_10800 ^@ http://purl.uniprot.org/uniprot/I1S219 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_03049 ^@ http://purl.uniprot.org/uniprot/I1RH13 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_06944 ^@ http://purl.uniprot.org/uniprot/I1RS37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02735 ^@ http://purl.uniprot.org/uniprot/I1RG80 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/229533:FGSG_06385 ^@ http://purl.uniprot.org/uniprot/I1RQN9 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/229533:FGSG_07245 ^@ http://purl.uniprot.org/uniprot/I1RSW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00884 ^@ http://purl.uniprot.org/uniprot/A0A1I9EX16|||http://purl.uniprot.org/uniprot/Q4IPH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase H subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_04504 ^@ http://purl.uniprot.org/uniprot/I1RKT7 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. Purple acid phosphatase family. http://togogenome.org/gene/229533:FGSG_13714 ^@ http://purl.uniprot.org/uniprot/I1SA33 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/229533:FGSG_08588 ^@ http://purl.uniprot.org/uniprot/I1RWC4 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/229533:FGSG_09287 ^@ http://purl.uniprot.org/uniprot/I1RY52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_07226 ^@ http://purl.uniprot.org/uniprot/I1RSU2 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/229533:FGSG_05450 ^@ http://purl.uniprot.org/uniprot/I1RN84 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/229533:FGSG_07518 ^@ http://purl.uniprot.org/uniprot/I1RTK9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_04673 ^@ http://purl.uniprot.org/uniprot/I1RL87 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_04262 ^@ http://purl.uniprot.org/uniprot/I1RK69 ^@ Similarity ^@ Belongs to the asteroid family. http://togogenome.org/gene/229533:FGSG_02811 ^@ http://purl.uniprot.org/uniprot/I1RGF1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_06916 ^@ http://purl.uniprot.org/uniprot/I1RS12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09665 ^@ http://purl.uniprot.org/uniprot/I1RZ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08914 ^@ http://purl.uniprot.org/uniprot/I1RX64 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07826 ^@ http://purl.uniprot.org/uniprot/V6RIV7 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/229533:FGSG_04777 ^@ http://purl.uniprot.org/uniprot/I1RLH7 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_05392 ^@ http://purl.uniprot.org/uniprot/I1RN30 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_01198 ^@ http://purl.uniprot.org/uniprot/I1RC95 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_04909 ^@ http://purl.uniprot.org/uniprot/I1RLU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. USB1 family.|||Nucleus|||Phosphodiesterase responsible for the U6 snRNA 3' end processing. Acts as an exoribonuclease (RNase) responsible for trimming the poly(U) tract of the last nucleotides in the pre-U6 snRNA molecule, leading to the formation of mature U6 snRNA. http://togogenome.org/gene/229533:FGSG_04832 ^@ http://purl.uniprot.org/uniprot/I1RLM5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_09364 ^@ http://purl.uniprot.org/uniprot/V6RVE9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06117 ^@ http://purl.uniprot.org/uniprot/I1RPY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 4 family.|||Secreted http://togogenome.org/gene/229533:FGSG_02278 ^@ http://purl.uniprot.org/uniprot/I1RF15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01561 ^@ http://purl.uniprot.org/uniprot/I1RD72 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Peroxisome http://togogenome.org/gene/229533:FGSG_01348 ^@ http://purl.uniprot.org/uniprot/I1RCM7 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/229533:FGSG_08402 ^@ http://purl.uniprot.org/uniprot/I1RVV7 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/229533:FGSG_07078 ^@ http://purl.uniprot.org/uniprot/I1RSG0 ^@ Similarity ^@ Belongs to the pex2/pex10/pex12 family. http://togogenome.org/gene/229533:FGSG_11387 ^@ http://purl.uniprot.org/uniprot/I1S3K0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06305 ^@ http://purl.uniprot.org/uniprot/I1RQG3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_03609 ^@ http://purl.uniprot.org/uniprot/I1RIH6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_02686 ^@ http://purl.uniprot.org/uniprot/I1RG37 ^@ Similarity ^@ Belongs to the RNase T2 family. http://togogenome.org/gene/229533:FGSG_02358 ^@ http://purl.uniprot.org/uniprot/V6QZK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04317 ^@ http://purl.uniprot.org/uniprot/V6R3I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10295 ^@ http://purl.uniprot.org/uniprot/I1S0Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03851 ^@ http://purl.uniprot.org/uniprot/I1RJ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/229533:FGSG_02555 ^@ http://purl.uniprot.org/uniprot/V6R057 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_03847 ^@ http://purl.uniprot.org/uniprot/I1RJ46 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/229533:FGSG_04268 ^@ http://purl.uniprot.org/uniprot/I1RK75 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. http://togogenome.org/gene/229533:FGSG_06158 ^@ http://purl.uniprot.org/uniprot/I1RQ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/229533:FGSG_03075 ^@ http://purl.uniprot.org/uniprot/I1RH36 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/229533:FGSG_05124 ^@ http://purl.uniprot.org/uniprot/I1RMD5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP16 family.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_05058 ^@ http://purl.uniprot.org/uniprot/I1RM75 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/229533:FGSG_00810 ^@ http://purl.uniprot.org/uniprot/I1RBA0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05443 ^@ http://purl.uniprot.org/uniprot/I1RN77 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/229533:FGSG_01257 ^@ http://purl.uniprot.org/uniprot/I1RCE7 ^@ Function|||Similarity ^@ Belongs to the SEC10 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/229533:FGSG_02041 ^@ http://purl.uniprot.org/uniprot/I1REF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08380 ^@ http://purl.uniprot.org/uniprot/I1RVT7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Nucleus|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/229533:FGSG_08760 ^@ http://purl.uniprot.org/uniprot/I1RWT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/229533:FGSG_11054 ^@ http://purl.uniprot.org/uniprot/I1S2Q4 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/229533:FGSG_07606 ^@ http://purl.uniprot.org/uniprot/I1RTU0 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_07540 ^@ http://purl.uniprot.org/uniprot/I1RTM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_11897 ^@ http://purl.uniprot.org/uniprot/I1S4X9 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/229533:FGSG_06527 ^@ http://purl.uniprot.org/uniprot/I1RR22 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28A subfamily. http://togogenome.org/gene/229533:FGSG_05203 ^@ http://purl.uniprot.org/uniprot/I1RML2 ^@ Function|||Subcellular Location Annotation ^@ RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_01092 ^@ http://purl.uniprot.org/uniprot/A0A1I9EXN1|||http://purl.uniprot.org/uniprot/Q4INW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex. http://togogenome.org/gene/229533:FGSG_01562 ^@ http://purl.uniprot.org/uniprot/V6QY41 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08106 ^@ http://purl.uniprot.org/uniprot/I1RV44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06300 ^@ http://purl.uniprot.org/uniprot/I1RQF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04232 ^@ http://purl.uniprot.org/uniprot/I1RK44 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02407 ^@ http://purl.uniprot.org/uniprot/I1RFD4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00502 ^@ http://purl.uniprot.org/uniprot/I1RAH2 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_04065 ^@ http://purl.uniprot.org/uniprot/I1RJN7 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/229533:FGSG_09406 ^@ http://purl.uniprot.org/uniprot/I1RYF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08410 ^@ http://purl.uniprot.org/uniprot/V6RKF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09381 ^@ http://purl.uniprot.org/uniprot/V6RPN0 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phytoene/squalene synthase family.|||Endoplasmic reticulum membrane|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Microsome|||Squalene synthase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG9 produces squalene from 2 farnesyl pyrophosphate moieties (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_00613 ^@ http://purl.uniprot.org/uniprot/I1RAS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07874 ^@ http://purl.uniprot.org/uniprot/I1RUI1 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/229533:FGSG_02766 ^@ http://purl.uniprot.org/uniprot/I1RGA8 ^@ Similarity ^@ Belongs to the UPF0507 family. http://togogenome.org/gene/229533:FGSG_11606 ^@ http://purl.uniprot.org/uniprot/I1S447 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03637 ^@ http://purl.uniprot.org/uniprot/I1RIK0 ^@ Similarity ^@ Belongs to the NtaA/SnaA/DszA monooxygenase family. http://togogenome.org/gene/229533:FGSG_08077 ^@ http://purl.uniprot.org/uniprot/I1RV17 ^@ Function|||Induction|||Similarity ^@ Belongs to the NADH:flavin oxidoreductase/NADH oxidase family. NamA subfamily.|||Highly expressed under trichothecene-producing conditions.|||NADH:flavin oxidoreductase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable). http://togogenome.org/gene/229533:FGSG_06225 ^@ http://purl.uniprot.org/uniprot/I1RQ86 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/229533:FGSG_03914 ^@ http://purl.uniprot.org/uniprot/I1RJA5 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/229533:FGSG_04726 ^@ http://purl.uniprot.org/uniprot/I1RLD2 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_08426 ^@ http://purl.uniprot.org/uniprot/I1RVX9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/229533:FGSG_10147 ^@ http://purl.uniprot.org/uniprot/I1S0C5 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/229533:FGSG_04368 ^@ http://purl.uniprot.org/uniprot/I1RKG6 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_02114 ^@ http://purl.uniprot.org/uniprot/I1REM2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00724 ^@ http://purl.uniprot.org/uniprot/I1RB20 ^@ Similarity ^@ Belongs to the pex2/pex10/pex12 family. http://togogenome.org/gene/229533:FGSG_06451 ^@ http://purl.uniprot.org/uniprot/I1RQV1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/229533:FGSG_08929 ^@ http://purl.uniprot.org/uniprot/V6RIS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/229533:FGSG_04887 ^@ http://purl.uniprot.org/uniprot/A0A1I9FRH9|||http://purl.uniprot.org/uniprot/Q4ID21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CGI121/TPRKB family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification.|||Nucleus|||telomere http://togogenome.org/gene/229533:FGSG_08943 ^@ http://purl.uniprot.org/uniprot/I1RX89 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_03160 ^@ http://purl.uniprot.org/uniprot/I1RHB4 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_08700 ^@ http://purl.uniprot.org/uniprot/I1RWM4 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/229533:FGSG_08806 ^@ http://purl.uniprot.org/uniprot/I1RWX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05498 ^@ http://purl.uniprot.org/uniprot/I1RNC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00840 ^@ http://purl.uniprot.org/uniprot/V6QVV9 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/229533:FGSG_11111 ^@ http://purl.uniprot.org/uniprot/I1S2V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01172 ^@ http://purl.uniprot.org/uniprot/I1RC69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10740 ^@ http://purl.uniprot.org/uniprot/I1S1W5 ^@ Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG8 family.|||Conjugation to phosphatidylethanolamine (PE) leads to homodimerization (By similarity). Interacts with ATG1, ATG3, ATG4, ATG7 and ATG12 (By similarity).|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||The C-terminal Glu-117 and Ala-118 residues of ATG8 are removed by ATG4 to expose Gly-116 at the C-terminus (By similarity). This Gly-116 forms then a thioester bond with the 'Cys-550' of ATG7 (E1-like activating enzyme) before being transferred to the 'Cys-244' of ATG3 (the specific E2 conjugating enzyme), in order to be finally amidated with phosphatidylethanolamine (By similarity). This lipid modification anchors ATG8 to membranes and can be reversed by ATG4, releasing soluble ATG8 (By similarity).|||Ubiquitin-like modifier involved in cytoplasm to vacuole transport (Cvt) vesicles and autophagosomes formation (By similarity). With ATG4, mediates the delivery of the vesicles and autophagosomes to the vacuole via the microtubule cytoskeleton (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Participates also in membrane fusion events that take place in the early secretory pathway (By similarity). Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Moreover not only conjugation, but also subsequent ATG8-PE deconjugation is an important step required to facilitate multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Vacuole membrane|||autophagosome membrane|||cvt vesicle membrane http://togogenome.org/gene/229533:FGSG_00595 ^@ http://purl.uniprot.org/uniprot/I1RAR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_12330 ^@ http://purl.uniprot.org/uniprot/I1S659 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05506 ^@ http://purl.uniprot.org/uniprot/I1RND3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02019 ^@ http://purl.uniprot.org/uniprot/I1RED2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/229533:FGSG_02146 ^@ http://purl.uniprot.org/uniprot/I1REQ1 ^@ Function|||Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. http://togogenome.org/gene/229533:FGSG_05249 ^@ http://purl.uniprot.org/uniprot/I1RMQ4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_06370 ^@ http://purl.uniprot.org/uniprot/I1RQM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/229533:FGSG_10828 ^@ http://purl.uniprot.org/uniprot/I1S244 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10782 ^@ http://purl.uniprot.org/uniprot/I1S202 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_00299 ^@ http://purl.uniprot.org/uniprot/I1R9Y3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 63 family. http://togogenome.org/gene/229533:FGSG_11275 ^@ http://purl.uniprot.org/uniprot/I1S3A0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02009 ^@ http://purl.uniprot.org/uniprot/I1REC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_02778 ^@ http://purl.uniprot.org/uniprot/I1RGB9 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/229533:FGSG_05297 ^@ http://purl.uniprot.org/uniprot/I1RMU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium. http://togogenome.org/gene/229533:FGSG_08668 ^@ http://purl.uniprot.org/uniprot/I1RWJ6 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/229533:FGSG_09196 ^@ http://purl.uniprot.org/uniprot/I1RXX0 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/229533:FGSG_11986 ^@ http://purl.uniprot.org/uniprot/I1S568 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_06581 ^@ http://purl.uniprot.org/uniprot/A0A1I9FF31|||http://purl.uniprot.org/uniprot/Q4I877 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nudE family.|||Required for nuclear migration.|||Self-associates. Interacts with PAC1 (By similarity).|||cytoskeleton http://togogenome.org/gene/229533:FGSG_03692 ^@ http://purl.uniprot.org/uniprot/I1RIQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08335 ^@ http://purl.uniprot.org/uniprot/I1RVQ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/229533:FGSG_00152 ^@ http://purl.uniprot.org/uniprot/I1R9K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07054 ^@ http://purl.uniprot.org/uniprot/I1RSD7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_01158 ^@ http://purl.uniprot.org/uniprot/I1RC55 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/229533:FGSG_02304 ^@ http://purl.uniprot.org/uniprot/I1RF38 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_12649 ^@ http://purl.uniprot.org/uniprot/I1S726 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/229533:FGSG_04396 ^@ http://purl.uniprot.org/uniprot/I1RKJ0 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/229533:FGSG_05821 ^@ http://purl.uniprot.org/uniprot/I1RP68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_08930 ^@ http://purl.uniprot.org/uniprot/I1RX79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03532 ^@ http://purl.uniprot.org/uniprot/I1RIA2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/229533:FGSG_00970 ^@ http://purl.uniprot.org/uniprot/I1RBN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02762 ^@ http://purl.uniprot.org/uniprot/I1RGA4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/229533:FGSG_04352 ^@ http://purl.uniprot.org/uniprot/I1RKF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07516 ^@ http://purl.uniprot.org/uniprot/I1RTK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08816 ^@ http://purl.uniprot.org/uniprot/I1RWX9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_09226 ^@ http://purl.uniprot.org/uniprot/I1RXZ9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/229533:FGSG_06246 ^@ http://purl.uniprot.org/uniprot/I1RQA5 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/229533:FGSG_00768 ^@ http://purl.uniprot.org/uniprot/I1RB61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03803 ^@ http://purl.uniprot.org/uniprot/I1RJ05 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/229533:FGSG_04350 ^@ http://purl.uniprot.org/uniprot/A0A1I9FFB7|||http://purl.uniprot.org/uniprot/Q4IEK8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.|||Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.|||Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_10908 ^@ http://purl.uniprot.org/uniprot/I1S2C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||Required for pre-18S rRNA processing. May bind microtubules.|||nucleolus http://togogenome.org/gene/229533:FGSG_10200 ^@ http://purl.uniprot.org/uniprot/I1S0H2 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/229533:FGSG_11842 ^@ http://purl.uniprot.org/uniprot/I1S4S4 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria. http://togogenome.org/gene/229533:FGSG_03307 ^@ http://purl.uniprot.org/uniprot/I1RHP6 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_03462 ^@ http://purl.uniprot.org/uniprot/I1RI39 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 31 family.|||Glucosidase involved in the degradation of cellulosic biomass. Has both alpha- and beta-glucosidase activity. http://togogenome.org/gene/229533:FGSG_01318 ^@ http://purl.uniprot.org/uniprot/I1RCK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05174 ^@ http://purl.uniprot.org/uniprot/I1RMI4 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/229533:FGSG_00134 ^@ http://purl.uniprot.org/uniprot/I1R9J2 ^@ Similarity ^@ Belongs to the aegerolysin family. http://togogenome.org/gene/229533:FGSG_06376 ^@ http://purl.uniprot.org/uniprot/I1RQN0 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/229533:FGSG_01896 ^@ http://purl.uniprot.org/uniprot/I1RE23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/229533:FGSG_06958 ^@ http://purl.uniprot.org/uniprot/I1RS49 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_02469 ^@ http://purl.uniprot.org/uniprot/I1RFJ1 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THI4 family.|||Binds 1 Fe cation per subunit.|||Cytoplasm|||During the catalytic reaction, a sulfide is transferred from Cys-211 to a reaction intermediate, generating a dehydroalanine residue.|||Homooctamer.|||Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.|||Nucleus http://togogenome.org/gene/229533:FGSG_09239 ^@ http://purl.uniprot.org/uniprot/I1RY11 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_01569 ^@ http://purl.uniprot.org/uniprot/I1RD77 ^@ Caution|||Similarity ^@ Belongs to the peptidase C2 family. PalB/RIM13 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00124 ^@ http://purl.uniprot.org/uniprot/I1R9I3 ^@ Similarity ^@ Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_05972 ^@ http://purl.uniprot.org/uniprot/I1RPK0 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/229533:FGSG_09921 ^@ http://purl.uniprot.org/uniprot/I1RZR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11405 ^@ http://purl.uniprot.org/uniprot/I1S3L6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_00586 ^@ http://purl.uniprot.org/uniprot/I1RAQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05108 ^@ http://purl.uniprot.org/uniprot/I1RMC0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/229533:FGSG_05882 ^@ http://purl.uniprot.org/uniprot/I1RPC0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_10264 ^@ http://purl.uniprot.org/uniprot/V6RY56 ^@ Similarity|||Subunit ^@ Belongs to the glutamine synthetase family.|||Homooctamer. http://togogenome.org/gene/229533:FGSG_08599 ^@ http://purl.uniprot.org/uniprot/I1RWD5 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/229533:FGSG_08466 ^@ http://purl.uniprot.org/uniprot/I1RW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_08518 ^@ http://purl.uniprot.org/uniprot/V6RLH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02597 ^@ http://purl.uniprot.org/uniprot/I1RFV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_01095 ^@ http://purl.uniprot.org/uniprot/I1RBZ6 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/229533:FGSG_09907 ^@ http://purl.uniprot.org/uniprot/I1RZQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03375 ^@ http://purl.uniprot.org/uniprot/I1RHV9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_09312 ^@ http://purl.uniprot.org/uniprot/I1RY74 ^@ Function|||Similarity ^@ Belongs to the PanB family.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. http://togogenome.org/gene/229533:FGSG_05516 ^@ http://purl.uniprot.org/uniprot/I1RNE2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/229533:FGSG_02852 ^@ http://purl.uniprot.org/uniprot/I1RGI5 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/229533:FGSG_07875 ^@ http://purl.uniprot.org/uniprot/I1RUI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07040 ^@ http://purl.uniprot.org/uniprot/I1RSC4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_03732 ^@ http://purl.uniprot.org/uniprot/I1RIT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00507 ^@ http://purl.uniprot.org/uniprot/I1RAH7 ^@ Similarity ^@ Belongs to the COG4 family. http://togogenome.org/gene/229533:FGSG_00615 ^@ http://purl.uniprot.org/uniprot/I1RAS9 ^@ Function|||Subcellular Location Annotation ^@ Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment.|||Membrane|||Prevacuolar compartment membrane|||trans-Golgi network membrane http://togogenome.org/gene/229533:FGSG_01099 ^@ http://purl.uniprot.org/uniprot/I1RC00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/229533:FGSG_11411 ^@ http://purl.uniprot.org/uniprot/I1S3M2 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_01439 ^@ http://purl.uniprot.org/uniprot/I1RCV7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06113 ^@ http://purl.uniprot.org/uniprot/I1RPY1 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/229533:FGSG_07457 ^@ http://purl.uniprot.org/uniprot/I1RTF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_07259 ^@ http://purl.uniprot.org/uniprot/I1RSX2 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/229533:FGSG_04263 ^@ http://purl.uniprot.org/uniprot/I1RK70 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/229533:FGSG_09344 ^@ http://purl.uniprot.org/uniprot/I1RYA2 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/229533:FGSG_07195 ^@ http://purl.uniprot.org/uniprot/I1RSR4 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/229533:FGSG_05157 ^@ http://purl.uniprot.org/uniprot/I1RMG7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07584 ^@ http://purl.uniprot.org/uniprot/I1RTR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08037 ^@ http://purl.uniprot.org/uniprot/I1RUX8 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_05631 ^@ http://purl.uniprot.org/uniprot/I1RNP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/229533:FGSG_01592 ^@ http://purl.uniprot.org/uniprot/I1RDA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/229533:FGSG_07310 ^@ http://purl.uniprot.org/uniprot/I1RT19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STE12 transcription factor family.|||Nucleus http://togogenome.org/gene/229533:FGSG_04235 ^@ http://purl.uniprot.org/uniprot/I1RK47 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/229533:FGSG_09863 ^@ http://purl.uniprot.org/uniprot/I1RZL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/229533:FGSG_04588 ^@ http://purl.uniprot.org/uniprot/I1RL11 ^@ Biotechnology|||Domain|||Function ^@ Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; a methyltransferase (CMeT) domain responsible for methylations; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.|||Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_07569 ^@ http://purl.uniprot.org/uniprot/I1RTQ5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/229533:FGSG_06724 ^@ http://purl.uniprot.org/uniprot/I1RRJ8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/229533:FGSG_03384 ^@ http://purl.uniprot.org/uniprot/I1RHW8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_06810 ^@ http://purl.uniprot.org/uniprot/I1RRS3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06900 ^@ http://purl.uniprot.org/uniprot/I1RRZ6 ^@ Similarity ^@ In the C-terminal section; belongs to the MoaC family.|||In the N-terminal section; belongs to the radical SAM superfamily. MoaA family. http://togogenome.org/gene/229533:FGSG_05211 ^@ http://purl.uniprot.org/uniprot/I1RML9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06801 ^@ http://purl.uniprot.org/uniprot/I1RRR6 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/229533:FGSG_05013 ^@ http://purl.uniprot.org/uniprot/I1RM36 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06513 ^@ http://purl.uniprot.org/uniprot/I1RR10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NiCoT transporter (TC 2.A.52) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_03394 ^@ http://purl.uniprot.org/uniprot/I1RHX8 ^@ Similarity ^@ Belongs to the Necrosis inducing protein (NPP1) family. http://togogenome.org/gene/229533:FGSG_01031 ^@ http://purl.uniprot.org/uniprot/I1RBU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/229533:FGSG_09865 ^@ http://purl.uniprot.org/uniprot/I1RZL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06816 ^@ http://purl.uniprot.org/uniprot/I1RRS8 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_07765 ^@ http://purl.uniprot.org/uniprot/I1RU81 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_05243 ^@ http://purl.uniprot.org/uniprot/I1RMP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_07781 ^@ http://purl.uniprot.org/uniprot/I1RU96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08545 ^@ http://purl.uniprot.org/uniprot/I1RW84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS27 family.|||Component of the ESCRT-0 complex composed of HSE1 and VPS27.|||Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.|||Endosome membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04923 ^@ http://purl.uniprot.org/uniprot/I1RLV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08861 ^@ http://purl.uniprot.org/uniprot/I1RX18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07469 ^@ http://purl.uniprot.org/uniprot/I1RTG5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/229533:FGSG_10837 ^@ http://purl.uniprot.org/uniprot/I1S253 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/229533:FGSG_11211 ^@ http://purl.uniprot.org/uniprot/I1S346 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_11487 ^@ http://purl.uniprot.org/uniprot/A0A1I9FYC9|||http://purl.uniprot.org/uniprot/I1S3T9 ^@ Activity Regulation|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family.|||Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.|||Expression is under the control of transcription factor XYR1 and highly induced by xylan, carboxymethylcellulose (CMC), and hop cell wall.|||Secreted|||Weakly inhibited by the wheat xylanase inhibiting protein I (XIP-I). http://togogenome.org/gene/229533:FGSG_03023 ^@ http://purl.uniprot.org/uniprot/I1RGZ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05670 ^@ http://purl.uniprot.org/uniprot/V6RIE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.|||Endoplasmic reticulum membrane http://togogenome.org/gene/229533:FGSG_07851 ^@ http://purl.uniprot.org/uniprot/V6RJP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFA13 subunit family.|||Complex I functions in the transfer of electrons from NADH to the respiratory chain. Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04827 ^@ http://purl.uniprot.org/uniprot/I1RLM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08080 ^@ http://purl.uniprot.org/uniprot/I1RV20 ^@ Function|||Induction|||Subcellular Location Annotation ^@ Highly expressed under trichothecene-producing conditions.|||Nucleus|||Transcription factor that regulates the expression of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat. http://togogenome.org/gene/229533:FGSG_10538 ^@ http://purl.uniprot.org/uniprot/I1S1D8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/229533:FGSG_12523 ^@ http://purl.uniprot.org/uniprot/I1S6Q0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05591 ^@ http://purl.uniprot.org/uniprot/I1RNK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_00482 ^@ http://purl.uniprot.org/uniprot/A0A1I9EVI6|||http://purl.uniprot.org/uniprot/Q4IQM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS4/SLD5 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication.|||The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). http://togogenome.org/gene/229533:FGSG_09804 ^@ http://purl.uniprot.org/uniprot/I1RZG4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07482 ^@ http://purl.uniprot.org/uniprot/I1RTH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05844 ^@ http://purl.uniprot.org/uniprot/I1RP87 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/229533:FGSG_00303 ^@ http://purl.uniprot.org/uniprot/I1R9Y7 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/229533:FGSG_09003 ^@ http://purl.uniprot.org/uniprot/I1RXD7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/229533:FGSG_11399 ^@ http://purl.uniprot.org/uniprot/I1S3L1 ^@ Function|||Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable). http://togogenome.org/gene/229533:FGSG_05213 ^@ http://purl.uniprot.org/uniprot/I1RMM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy.|||Membrane http://togogenome.org/gene/229533:FGSG_13655 ^@ http://purl.uniprot.org/uniprot/I1S9X4 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_11686 ^@ http://purl.uniprot.org/uniprot/I1S4B9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09397 ^@ http://purl.uniprot.org/uniprot/A0A1I9FHG1|||http://purl.uniprot.org/uniprot/Q4I061 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/229533:FGSG_05446 ^@ http://purl.uniprot.org/uniprot/I1RN80 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/229533:FGSG_01785 ^@ http://purl.uniprot.org/uniprot/I1RDS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03778 ^@ http://purl.uniprot.org/uniprot/I1RIY1 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_07031 ^@ http://purl.uniprot.org/uniprot/I1RSB7 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/229533:FGSG_08896 ^@ http://purl.uniprot.org/uniprot/I1RX46 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/229533:FGSG_03330 ^@ http://purl.uniprot.org/uniprot/I1RHR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07181 ^@ http://purl.uniprot.org/uniprot/I1RSQ3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/229533:FGSG_00947 ^@ http://purl.uniprot.org/uniprot/I1RBL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04298 ^@ http://purl.uniprot.org/uniprot/A0A1I9FG29|||http://purl.uniprot.org/uniprot/Q4IER0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity).|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues. http://togogenome.org/gene/229533:FGSG_03649 ^@ http://purl.uniprot.org/uniprot/I1RIL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01957 ^@ http://purl.uniprot.org/uniprot/I1RE78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_09103 ^@ http://purl.uniprot.org/uniprot/I1RXM9 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_07337 ^@ http://purl.uniprot.org/uniprot/I1RT43 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09710 ^@ http://purl.uniprot.org/uniprot/I1RZ83 ^@ Similarity ^@ In the C-terminal section; belongs to the DHPS family. http://togogenome.org/gene/229533:FGSG_03322 ^@ http://purl.uniprot.org/uniprot/I1RHR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07454 ^@ http://purl.uniprot.org/uniprot/I1RTF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10344 ^@ http://purl.uniprot.org/uniprot/I1S0V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06207 ^@ http://purl.uniprot.org/uniprot/I1RQ68 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/229533:FGSG_11181 ^@ http://purl.uniprot.org/uniprot/I1S320 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_04164 ^@ http://purl.uniprot.org/uniprot/A0A1I9FCP5|||http://purl.uniprot.org/uniprot/Q4IF44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus|||Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. http://togogenome.org/gene/229533:FGSG_05377 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQ28|||http://purl.uniprot.org/uniprot/Q4IBN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VTS1 family.|||Monomer. Binds to RNA.|||P-body|||RNA-binding protein involved in post-transcriptional regulation through transcript degradation.|||cytosol http://togogenome.org/gene/229533:FGSG_06191 ^@ http://purl.uniprot.org/uniprot/A0A1I9FUF1|||http://purl.uniprot.org/uniprot/Q4I9B7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLASP family.|||Interacts with microtubules.|||Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).|||Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation.|||Nucleus|||cytoskeleton|||spindle http://togogenome.org/gene/229533:FGSG_03171 ^@ http://purl.uniprot.org/uniprot/I1RHC5 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/229533:FGSG_04242 ^@ http://purl.uniprot.org/uniprot/I1RK54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10330 ^@ http://purl.uniprot.org/uniprot/I1S0U1 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_02661 ^@ http://purl.uniprot.org/uniprot/I1RG12 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/229533:FGSG_02155 ^@ http://purl.uniprot.org/uniprot/I1RER0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_07628 ^@ http://purl.uniprot.org/uniprot/I1RTW0 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_00397 ^@ http://purl.uniprot.org/uniprot/I1RA72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_10395 ^@ http://purl.uniprot.org/uniprot/I1S102 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_10320 ^@ http://purl.uniprot.org/uniprot/I1S0T2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24 family.|||Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01212 ^@ http://purl.uniprot.org/uniprot/I1RCA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC3 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06195 ^@ http://purl.uniprot.org/uniprot/I1RQ58 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/229533:FGSG_11094 ^@ http://purl.uniprot.org/uniprot/I1S2U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 3 family.|||Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.|||Secreted http://togogenome.org/gene/229533:FGSG_05320 ^@ http://purl.uniprot.org/uniprot/I1RMW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/229533:FGSG_11186 ^@ http://purl.uniprot.org/uniprot/I1S325 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09383 ^@ http://purl.uniprot.org/uniprot/I1RYD7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/229533:FGSG_13617 ^@ http://purl.uniprot.org/uniprot/I1S9T6 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/229533:FGSG_02138 ^@ http://purl.uniprot.org/uniprot/I1REP4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_03159 ^@ http://purl.uniprot.org/uniprot/I1RHB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02077 ^@ http://purl.uniprot.org/uniprot/I1REI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_09169 ^@ http://purl.uniprot.org/uniprot/I1RXU3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_06960 ^@ http://purl.uniprot.org/uniprot/I1RS50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M76 family.|||Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_05322 ^@ http://purl.uniprot.org/uniprot/I1RMW9 ^@ Similarity ^@ Belongs to the fungal fatty acid synthetase subunit beta family. http://togogenome.org/gene/229533:FGSG_07917 ^@ http://purl.uniprot.org/uniprot/I1RUL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10374 ^@ http://purl.uniprot.org/uniprot/I1S0Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Delta(4)-fatty-acid desaturase which introduces a double bond at the 4-position in the long-chain base (LCB) of ceramides.|||Membrane http://togogenome.org/gene/229533:FGSG_07436 ^@ http://purl.uniprot.org/uniprot/I1RTD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_13888 ^@ http://purl.uniprot.org/uniprot/I1SAK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09555 ^@ http://purl.uniprot.org/uniprot/I1RYU6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Binds 1 AMP per subunit.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/229533:FGSG_01552 ^@ http://purl.uniprot.org/uniprot/I1RD63 ^@ Similarity ^@ Belongs to the VPS29 family. http://togogenome.org/gene/229533:FGSG_00636 ^@ http://purl.uniprot.org/uniprot/A0A1I9EW15|||http://purl.uniprot.org/uniprot/Q4IQ72 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_12421 ^@ http://purl.uniprot.org/uniprot/I1S6F0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/229533:FGSG_01731 ^@ http://purl.uniprot.org/uniprot/I1RDM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00600 ^@ http://purl.uniprot.org/uniprot/I1RAR5 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_12134 ^@ http://purl.uniprot.org/uniprot/I1S5L3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12862 ^@ http://purl.uniprot.org/uniprot/I1S7N7 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/229533:FGSG_04892 ^@ http://purl.uniprot.org/uniprot/I1RLS4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_06575 ^@ http://purl.uniprot.org/uniprot/I1RR63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0187 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06560 ^@ http://purl.uniprot.org/uniprot/I1RR51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24 family.|||Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_05723 ^@ http://purl.uniprot.org/uniprot/I1RNX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05511 ^@ http://purl.uniprot.org/uniprot/I1RND8 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/229533:FGSG_07939 ^@ http://purl.uniprot.org/uniprot/I1RUN9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. http://togogenome.org/gene/229533:FGSG_11617 ^@ http://purl.uniprot.org/uniprot/I1S456 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_05384 ^@ http://purl.uniprot.org/uniprot/I1RN23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07406 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJ43|||http://purl.uniprot.org/uniprot/Q4I5V2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_09498 ^@ http://purl.uniprot.org/uniprot/I1RYP0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11559 ^@ http://purl.uniprot.org/uniprot/I1S407 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_00118 ^@ http://purl.uniprot.org/uniprot/I1R9H7 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_08431 ^@ http://purl.uniprot.org/uniprot/I1RVY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11027 ^@ http://purl.uniprot.org/uniprot/I1S2M8 ^@ Similarity ^@ Belongs to the lysine N-acyltransferase MbtK family. http://togogenome.org/gene/229533:FGSG_04115 ^@ http://purl.uniprot.org/uniprot/I1RJT3 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/229533:FGSG_04149 ^@ http://purl.uniprot.org/uniprot/I1RJW6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/229533:FGSG_04186 ^@ http://purl.uniprot.org/uniprot/I1RK02 ^@ Similarity ^@ Belongs to the GPAT/DAPAT family. http://togogenome.org/gene/229533:FGSG_02773 ^@ http://purl.uniprot.org/uniprot/I1RGB5 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/229533:FGSG_10426 ^@ http://purl.uniprot.org/uniprot/I1S132 ^@ Similarity ^@ Belongs to the lysine N-acyltransferase MbtK family. http://togogenome.org/gene/229533:FGSG_03315 ^@ http://purl.uniprot.org/uniprot/I1RHQ4 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_04103 ^@ http://purl.uniprot.org/uniprot/I1RJS1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_09323 ^@ http://purl.uniprot.org/uniprot/I1RY83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05413 ^@ http://purl.uniprot.org/uniprot/I1RN49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01475 ^@ http://purl.uniprot.org/uniprot/I1RCY9 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_05520 ^@ http://purl.uniprot.org/uniprot/V6RAN7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/229533:FGSG_02922 ^@ http://purl.uniprot.org/uniprot/I1RGP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04130 ^@ http://purl.uniprot.org/uniprot/I1RJU8 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/229533:FGSG_04458 ^@ http://purl.uniprot.org/uniprot/I1RKP5 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_12251 ^@ http://purl.uniprot.org/uniprot/I1S5Y0 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_07134 ^@ http://purl.uniprot.org/uniprot/I1RSL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09368 ^@ http://purl.uniprot.org/uniprot/I1RYC3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08919 ^@ http://purl.uniprot.org/uniprot/I1RX69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||actin patch http://togogenome.org/gene/229533:FGSG_07854 ^@ http://purl.uniprot.org/uniprot/I1RUG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/229533:FGSG_10513 ^@ http://purl.uniprot.org/uniprot/I1S1B3 ^@ Similarity ^@ Belongs to the CDIP1/LITAF family. http://togogenome.org/gene/229533:FGSG_10947 ^@ http://purl.uniprot.org/uniprot/I1S2F5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09725 ^@ http://purl.uniprot.org/uniprot/I1RZ95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Peroxisome matrix http://togogenome.org/gene/229533:FGSG_10032 ^@ http://purl.uniprot.org/uniprot/I1S020 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04911 ^@ http://purl.uniprot.org/uniprot/I1RLU2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane|||May function both as a monomer and a homodimer. http://togogenome.org/gene/229533:FGSG_10010 ^@ http://purl.uniprot.org/uniprot/I1RZZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_03170 ^@ http://purl.uniprot.org/uniprot/I1RHC4 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_00945 ^@ http://purl.uniprot.org/uniprot/Q4IPB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.|||Cytoplasm|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity). http://togogenome.org/gene/229533:FGSG_00460 ^@ http://purl.uniprot.org/uniprot/I1RAD3 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/229533:FGSG_04776 ^@ http://purl.uniprot.org/uniprot/I1RLH6 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_10742 ^@ http://purl.uniprot.org/uniprot/I1S1W7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRM1 family.|||Cell membrane|||Involved in cell fusion during mating by stabilizing the plasma membrane fusion event.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_04370 ^@ http://purl.uniprot.org/uniprot/I1RKG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08997 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKU8|||http://purl.uniprot.org/uniprot/Q4I1B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_03887 ^@ http://purl.uniprot.org/uniprot/I1RJ79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05403 ^@ http://purl.uniprot.org/uniprot/Q4IBK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL2 subfamily.|||May catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides thereby assisting the folding of proteins. May also function as a chaperone, playing a role in intracellular transport of proteins. May also have a protein ubiquitin ligase activity acting as an E3 ubiquitin protein ligase or as a ubiquitin-ubiquitin ligase promoting elongation of ubiquitin chains on proteins.|||Nucleus http://togogenome.org/gene/229533:FGSG_09429 ^@ http://purl.uniprot.org/uniprot/I1RYH6 ^@ Similarity ^@ Belongs to the NipSnap family. http://togogenome.org/gene/229533:FGSG_00305 ^@ http://purl.uniprot.org/uniprot/I1R9Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_02941 ^@ http://purl.uniprot.org/uniprot/I1RGR7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/229533:FGSG_06150 ^@ http://purl.uniprot.org/uniprot/I1RQ17 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/229533:FGSG_05513 ^@ http://purl.uniprot.org/uniprot/I1RND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPP2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07370 ^@ http://purl.uniprot.org/uniprot/I1RT71 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/229533:FGSG_07080 ^@ http://purl.uniprot.org/uniprot/I1RSG2 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_10458 ^@ http://purl.uniprot.org/uniprot/I1S160 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription regulator that specifically up-regulates the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016). Probably binds the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes (PubMed:22252016). http://togogenome.org/gene/229533:FGSG_10345 ^@ http://purl.uniprot.org/uniprot/I1S0V5 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/229533:FGSG_00707 ^@ http://purl.uniprot.org/uniprot/I1RB08 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/229533:FGSG_06502 ^@ http://purl.uniprot.org/uniprot/I1RR00 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/229533:FGSG_01177 ^@ http://purl.uniprot.org/uniprot/I1RC74 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/229533:FGSG_11851 ^@ http://purl.uniprot.org/uniprot/I1S4T3 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Plays a pivotal role in conidiation by regulating cell cycle pathways and other conidiation-related genes (PubMed:24039821).|||Belongs to the TEC1 family.|||Expression is positively regulated by flbD (PubMed:25277408).|||Leads to abnormally shaped phialides and abolishes production of conidia (PubMed:24039821).|||Nucleus http://togogenome.org/gene/229533:FGSG_10722 ^@ http://purl.uniprot.org/uniprot/I1S1V0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_04144 ^@ http://purl.uniprot.org/uniprot/I1RJW1 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/229533:FGSG_13497 ^@ http://purl.uniprot.org/uniprot/I1S9G6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04799 ^@ http://purl.uniprot.org/uniprot/I1RLJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09166 ^@ http://purl.uniprot.org/uniprot/I1RXU0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06265 ^@ http://purl.uniprot.org/uniprot/I1RQC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC31 family.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13. http://togogenome.org/gene/229533:FGSG_01166 ^@ http://purl.uniprot.org/uniprot/I1RC63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/229533:FGSG_03599 ^@ http://purl.uniprot.org/uniprot/I1RIG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_11848 ^@ http://purl.uniprot.org/uniprot/I1S4T0 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/229533:FGSG_00539 ^@ http://purl.uniprot.org/uniprot/I1RAK8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Cell membrane|||Major facilitator transporter involved in extracellular siderophore uptake (PubMed:20507510). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875).|||Not expressed during infection (PubMed:20507510). http://togogenome.org/gene/229533:FGSG_00898 ^@ http://purl.uniprot.org/uniprot/I1RBH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/229533:FGSG_01155 ^@ http://purl.uniprot.org/uniprot/I1RC52 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/229533:FGSG_01973 ^@ http://purl.uniprot.org/uniprot/I1RE91 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/229533:FGSG_05912 ^@ http://purl.uniprot.org/uniprot/I1RPE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Homodimer.|||Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG12 converts mevalonate into 5-phosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).|||cytosol http://togogenome.org/gene/229533:FGSG_13641 ^@ http://purl.uniprot.org/uniprot/I1S9W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08677 ^@ http://purl.uniprot.org/uniprot/V6RKY8 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/229533:FGSG_06116 ^@ http://purl.uniprot.org/uniprot/I1RPY4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SNW family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/229533:FGSG_09049 ^@ http://purl.uniprot.org/uniprot/I1RXI0 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_06358 ^@ http://purl.uniprot.org/uniprot/I1RQL3 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/229533:FGSG_04042 ^@ http://purl.uniprot.org/uniprot/I1RJL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01411 ^@ http://purl.uniprot.org/uniprot/A0A1I9EYP3|||http://purl.uniprot.org/uniprot/Q4IMZ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.|||Endoplasmic reticulum membrane|||Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/229533:FGSG_06681 ^@ http://purl.uniprot.org/uniprot/I1RRG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasm|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/229533:FGSG_08412 ^@ http://purl.uniprot.org/uniprot/I1RVW5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01890 ^@ http://purl.uniprot.org/uniprot/I1RE18 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/229533:FGSG_08208 ^@ http://purl.uniprot.org/uniprot/I1RVD8 ^@ Disruption Phenotype|||Domain|||Function ^@ Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).|||Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (CMeT) domain responsible for the incorporation of methyl groups; an enoylreductase (ER) domain that reduces enoyl groups to alkyl group; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm.|||impairs the production of fusaristatin A. http://togogenome.org/gene/229533:FGSG_02908 ^@ http://purl.uniprot.org/uniprot/I1RGN6 ^@ Function|||Similarity ^@ Belongs to the choline monooxygenase family.|||Catalyzes the first step of the osmoprotectant glycine betaine synthesis. http://togogenome.org/gene/229533:FGSG_06142 ^@ http://purl.uniprot.org/uniprot/I1RQ09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07102 ^@ http://purl.uniprot.org/uniprot/I1RSI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05222 ^@ http://purl.uniprot.org/uniprot/I1RMM9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/229533:FGSG_09888 ^@ http://purl.uniprot.org/uniprot/I1RZN8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_02264 ^@ http://purl.uniprot.org/uniprot/I1RF03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10474 ^@ http://purl.uniprot.org/uniprot/I1S176 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04119 ^@ http://purl.uniprot.org/uniprot/I1RJT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02043 ^@ http://purl.uniprot.org/uniprot/I1REF5 ^@ Function ^@ Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA. http://togogenome.org/gene/229533:FGSG_12031 ^@ http://purl.uniprot.org/uniprot/I1S5B3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||Regulates also the sphingolipid metabolism. http://togogenome.org/gene/229533:FGSG_08579 ^@ http://purl.uniprot.org/uniprot/I1RWB6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06070 ^@ http://purl.uniprot.org/uniprot/I1RPU0 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/229533:FGSG_05160 ^@ http://purl.uniprot.org/uniprot/I1RMH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11179 ^@ http://purl.uniprot.org/uniprot/I1S318 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_06072 ^@ http://purl.uniprot.org/uniprot/I1RPU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_05048 ^@ http://purl.uniprot.org/uniprot/I1RM66 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_01717 ^@ http://purl.uniprot.org/uniprot/I1RDL0 ^@ Function ^@ Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis. http://togogenome.org/gene/229533:FGSG_10695 ^@ http://purl.uniprot.org/uniprot/I1S1S9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00852 ^@ http://purl.uniprot.org/uniprot/I1RBD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-Z subfamily.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_03269 ^@ http://purl.uniprot.org/uniprot/I1RHL0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/229533:FGSG_00741 ^@ http://purl.uniprot.org/uniprot/I1RB36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02770 ^@ http://purl.uniprot.org/uniprot/I1RGB2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/229533:FGSG_09792 ^@ http://purl.uniprot.org/uniprot/I1RZF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Nucleus http://togogenome.org/gene/229533:FGSG_06827 ^@ http://purl.uniprot.org/uniprot/I1RRT8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/229533:FGSG_04324 ^@ http://purl.uniprot.org/uniprot/I1RKC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/229533:FGSG_13715 ^@ http://purl.uniprot.org/uniprot/I1SA34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05093 ^@ http://purl.uniprot.org/uniprot/A0A1I9FSK4|||http://purl.uniprot.org/uniprot/Q4ICG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit APL3 and beta-type subunit APL1), a medium chain (mu-type subunit APM4) and a small adaptin (sigma-type subunit APS2).|||Belongs to the adaptor complexes small subunit family.|||Cell membrane|||Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration (By similarity).|||Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||coated pit http://togogenome.org/gene/229533:FGSG_06669 ^@ http://purl.uniprot.org/uniprot/I1RRE9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01959 ^@ http://purl.uniprot.org/uniprot/I1RE80 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||C-22 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG5A and ERG5B convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Leads to a severe decrease in conidiation and virulence when ERG5B is also deleted (PubMed:23442154). The absence of both ERG5A and ERG5B seems not to affect the ergosterol production (PubMed:24785759). http://togogenome.org/gene/229533:FGSG_03593 ^@ http://purl.uniprot.org/uniprot/I1RIG1 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_05359 ^@ http://purl.uniprot.org/uniprot/I1RN03 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05421 ^@ http://purl.uniprot.org/uniprot/I1RN57 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/229533:FGSG_01094 ^@ http://purl.uniprot.org/uniprot/I1RBZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_07003 ^@ http://purl.uniprot.org/uniprot/I1RS89 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_10343 ^@ http://purl.uniprot.org/uniprot/I1S0V3 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 Ca(2+) ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular space http://togogenome.org/gene/229533:FGSG_01421 ^@ http://purl.uniprot.org/uniprot/I1RCU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_13052 ^@ http://purl.uniprot.org/uniprot/I1S874 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LCL3 family.|||Membrane|||Mitochondrion http://togogenome.org/gene/229533:FGSG_04616 ^@ http://purl.uniprot.org/uniprot/I1RL36 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_01675 ^@ http://purl.uniprot.org/uniprot/I1RDH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02070 ^@ http://purl.uniprot.org/uniprot/I1REI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01621 ^@ http://purl.uniprot.org/uniprot/I1RDC7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_02596 ^@ http://purl.uniprot.org/uniprot/I1RFV5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MMM1 family.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking. http://togogenome.org/gene/229533:FGSG_13972 ^@ http://purl.uniprot.org/uniprot/I1SAU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_03548 ^@ http://purl.uniprot.org/uniprot/I1RIB7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_12471 ^@ http://purl.uniprot.org/uniprot/I1S6J9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_00148 ^@ http://purl.uniprot.org/uniprot/I1R9K4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00952 ^@ http://purl.uniprot.org/uniprot/I1RBM4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily. http://togogenome.org/gene/229533:FGSG_09294 ^@ http://purl.uniprot.org/uniprot/I1RY57 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/229533:FGSG_09440 ^@ http://purl.uniprot.org/uniprot/I1RYI7 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/229533:FGSG_09891 ^@ http://purl.uniprot.org/uniprot/I1RZP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. http://togogenome.org/gene/229533:FGSG_08012 ^@ http://purl.uniprot.org/uniprot/I1RUV5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_01852 ^@ http://purl.uniprot.org/uniprot/I1RDY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSH4 family.|||Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.|||Endosome membrane|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07381 ^@ http://purl.uniprot.org/uniprot/I1RT82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_08902 ^@ http://purl.uniprot.org/uniprot/I1RX52 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/229533:FGSG_03933 ^@ http://purl.uniprot.org/uniprot/I1RJC2 ^@ Similarity ^@ Belongs to the Cyclase 1 superfamily. http://togogenome.org/gene/229533:FGSG_08479 ^@ http://purl.uniprot.org/uniprot/I1RW26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/229533:FGSG_01920 ^@ http://purl.uniprot.org/uniprot/I1RE46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_09957 ^@ http://purl.uniprot.org/uniprot/I1RZV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 28 family.|||Endoplasmic reticulum|||Heterodimer with ALG14 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. http://togogenome.org/gene/229533:FGSG_10116 ^@ http://purl.uniprot.org/uniprot/I1S097 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chitin synthase family.|||Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_07468 ^@ http://purl.uniprot.org/uniprot/I1RTG4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07294 ^@ http://purl.uniprot.org/uniprot/I1RT05 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/229533:FGSG_01333 ^@ http://purl.uniprot.org/uniprot/I1RCL4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_05956 ^@ http://purl.uniprot.org/uniprot/I1RPI5 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/229533:FGSG_08935 ^@ http://purl.uniprot.org/uniprot/I1RX83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/229533:FGSG_10424 ^@ http://purl.uniprot.org/uniprot/I1S130 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). MVD1 converts diphosphomevalonate into isopentenyl diphosphate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable).|||Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.|||Homodimer. http://togogenome.org/gene/229533:FGSG_03430 ^@ http://purl.uniprot.org/uniprot/V6RD34 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_09393 ^@ http://purl.uniprot.org/uniprot/I1RYE6 ^@ Function|||Similarity ^@ Belongs to the RTC5 family.|||May be involved in a process influencing telomere capping. http://togogenome.org/gene/229533:FGSG_09845 ^@ http://purl.uniprot.org/uniprot/I1RZJ8 ^@ Function ^@ Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis. http://togogenome.org/gene/229533:FGSG_07625 ^@ http://purl.uniprot.org/uniprot/I1RTV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-L-arabinofuranosidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases L-arabinose from arabinoxylan.|||Belongs to the glycosyl hydrolase 62 family.|||Secreted http://togogenome.org/gene/229533:FGSG_03824 ^@ http://purl.uniprot.org/uniprot/I1RJ25 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_10434 ^@ http://purl.uniprot.org/uniprot/I1S139 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_02370 ^@ http://purl.uniprot.org/uniprot/I1RFA1 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_07926 ^@ http://purl.uniprot.org/uniprot/I1RUM7 ^@ Similarity ^@ In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/229533:FGSG_09063 ^@ http://purl.uniprot.org/uniprot/I1RXJ2 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_08823 ^@ http://purl.uniprot.org/uniprot/I1RWY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05554 ^@ http://purl.uniprot.org/uniprot/I1RNH4 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_03643 ^@ http://purl.uniprot.org/uniprot/I1RIK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10530 ^@ http://purl.uniprot.org/uniprot/I1S1D0 ^@ Function|||Similarity ^@ Belongs to the VPS13 family.|||Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis. http://togogenome.org/gene/229533:FGSG_07412 ^@ http://purl.uniprot.org/uniprot/I1RTB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAP-alpha family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09342 ^@ http://purl.uniprot.org/uniprot/V6RNU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07182 ^@ http://purl.uniprot.org/uniprot/I1RSQ4 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/229533:FGSG_09998 ^@ http://purl.uniprot.org/uniprot/I1RZY8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/229533:FGSG_03061 ^@ http://purl.uniprot.org/uniprot/I1RH23 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03083 ^@ http://purl.uniprot.org/uniprot/I1RH42 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_11193 ^@ http://purl.uniprot.org/uniprot/I1S332 ^@ Similarity ^@ Belongs to the alpha-acetolactate decarboxylase family. http://togogenome.org/gene/229533:FGSG_06003 ^@ http://purl.uniprot.org/uniprot/I1RPM8 ^@ Similarity ^@ Belongs to the CHS7 family. http://togogenome.org/gene/229533:FGSG_00675 ^@ http://purl.uniprot.org/uniprot/I1RAY1 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG14 family.|||Coiled-Coils at the N-terminal half are essential for autophagy (By similarity).|||Component of the autophagy-specific VPS34 PI3-kinase complex I (By similarity).|||Preautophagosomal structure membrane|||Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07333 ^@ http://purl.uniprot.org/uniprot/I1RT40 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/229533:FGSG_02657 ^@ http://purl.uniprot.org/uniprot/I1RG09 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/229533:FGSG_04136 ^@ http://purl.uniprot.org/uniprot/I1RJV3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/229533:FGSG_06368 ^@ http://purl.uniprot.org/uniprot/I1RQM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_02281 ^@ http://purl.uniprot.org/uniprot/I1RF18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00596 ^@ http://purl.uniprot.org/uniprot/I1RAR1 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/229533:FGSG_06941 ^@ http://purl.uniprot.org/uniprot/I1RS34 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/229533:FGSG_08174 ^@ http://purl.uniprot.org/uniprot/I1RVA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06227 ^@ http://purl.uniprot.org/uniprot/I1RQ88 ^@ Similarity ^@ Belongs to the CDC73 family. http://togogenome.org/gene/229533:FGSG_08338 ^@ http://purl.uniprot.org/uniprot/V6RKN5 ^@ Similarity ^@ Belongs to the class-I DAHP synthase family. http://togogenome.org/gene/229533:FGSG_08398 ^@ http://purl.uniprot.org/uniprot/I1RVV3 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. http://togogenome.org/gene/229533:FGSG_08529 ^@ http://purl.uniprot.org/uniprot/I1RW69 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/229533:FGSG_02634 ^@ http://purl.uniprot.org/uniprot/I1RFY8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_05778 ^@ http://purl.uniprot.org/uniprot/I1RP28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_08645 ^@ http://purl.uniprot.org/uniprot/I1RWH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01698 ^@ http://purl.uniprot.org/uniprot/I1RDJ7 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. http://togogenome.org/gene/229533:FGSG_01417 ^@ http://purl.uniprot.org/uniprot/I1RCT7 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/229533:FGSG_09739 ^@ http://purl.uniprot.org/uniprot/I1RZA7 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/229533:FGSG_06226 ^@ http://purl.uniprot.org/uniprot/I1RQ87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00017 ^@ http://purl.uniprot.org/uniprot/I1R989 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_05193 ^@ http://purl.uniprot.org/uniprot/I1RMK3 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/229533:FGSG_07452 ^@ http://purl.uniprot.org/uniprot/I1RTE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.|||Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_03680 ^@ http://purl.uniprot.org/uniprot/V6R6F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06018 ^@ http://purl.uniprot.org/uniprot/I1RPP2 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/229533:FGSG_06947 ^@ http://purl.uniprot.org/uniprot/I1RS40 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/229533:FGSG_07255 ^@ http://purl.uniprot.org/uniprot/V6RGB5 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/229533:FGSG_05072 ^@ http://purl.uniprot.org/uniprot/A0A1I9FVL9|||http://purl.uniprot.org/uniprot/Q4ICI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SVF1 family.|||Cytoplasm|||May be involved in the response to oxidative stress.|||Nucleus http://togogenome.org/gene/229533:FGSG_04275 ^@ http://purl.uniprot.org/uniprot/I1RK81 ^@ Function|||Similarity ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. http://togogenome.org/gene/229533:FGSG_01570 ^@ http://purl.uniprot.org/uniprot/I1RD78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_10113 ^@ http://purl.uniprot.org/uniprot/I1S094 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family. http://togogenome.org/gene/229533:FGSG_01432 ^@ http://purl.uniprot.org/uniprot/I1RCV0 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_09662 ^@ http://purl.uniprot.org/uniprot/I1RZ39 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/229533:FGSG_09000 ^@ http://purl.uniprot.org/uniprot/I1RXD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10794 ^@ http://purl.uniprot.org/uniprot/I1S213 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00409 ^@ http://purl.uniprot.org/uniprot/I1RA82 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/229533:FGSG_08967 ^@ http://purl.uniprot.org/uniprot/I1RXA7 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family.|||Belongs to the glycosyltransferase 77 family. http://togogenome.org/gene/229533:FGSG_04109 ^@ http://purl.uniprot.org/uniprot/I1RJS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01737 ^@ http://purl.uniprot.org/uniprot/I1RDM7 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_06937 ^@ http://purl.uniprot.org/uniprot/I1RS30 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/229533:FGSG_01220 ^@ http://purl.uniprot.org/uniprot/I1RCB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_04689 ^@ http://purl.uniprot.org/uniprot/I1RLA3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_07371 ^@ http://purl.uniprot.org/uniprot/I1RT72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/229533:FGSG_00102 ^@ http://purl.uniprot.org/uniprot/I1R9G3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00195 ^@ http://purl.uniprot.org/uniprot/I1R9P2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04282 ^@ http://purl.uniprot.org/uniprot/I1RK88 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/229533:FGSG_08394 ^@ http://purl.uniprot.org/uniprot/I1RVU9 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/229533:FGSG_06081 ^@ http://purl.uniprot.org/uniprot/I1RPV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07640 ^@ http://purl.uniprot.org/uniprot/I1RTX2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02921 ^@ http://purl.uniprot.org/uniprot/I1RGP8 ^@ Function|||Similarity ^@ Belongs to the choline monooxygenase family.|||Catalyzes the first step of the osmoprotectant glycine betaine synthesis. http://togogenome.org/gene/229533:FGSG_06587 ^@ http://purl.uniprot.org/uniprot/I1RR73 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/229533:FGSG_05432 ^@ http://purl.uniprot.org/uniprot/I1RN66 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/229533:FGSG_01109 ^@ http://purl.uniprot.org/uniprot/I1RC10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06605 ^@ http://purl.uniprot.org/uniprot/I1RR89 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_00725 ^@ http://purl.uniprot.org/uniprot/I1RB21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02328 ^@ http://purl.uniprot.org/uniprot/I1RF62 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multicopper oxidase family.|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).|||Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:15811992, PubMed:16879655).|||Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).|||Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||Secreted|||extracellular space http://togogenome.org/gene/229533:FGSG_06078 ^@ http://purl.uniprot.org/uniprot/I1RPU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A, B and C subunits. http://togogenome.org/gene/229533:FGSG_10444 ^@ http://purl.uniprot.org/uniprot/I1S147 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/229533:FGSG_05217 ^@ http://purl.uniprot.org/uniprot/I1RMM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/229533:FGSG_02010 ^@ http://purl.uniprot.org/uniprot/I1REC3 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/229533:FGSG_05299 ^@ http://purl.uniprot.org/uniprot/I1RMU9 ^@ Function|||Similarity ^@ Belongs to the MoeA family.|||Catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released.|||In the C-terminal section; belongs to the MoeA family.|||In the N-terminal section; belongs to the MoaB/Mog family. http://togogenome.org/gene/229533:FGSG_03162 ^@ http://purl.uniprot.org/uniprot/I1RHB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06789 ^@ http://purl.uniprot.org/uniprot/I1RRQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07550 ^@ http://purl.uniprot.org/uniprot/I1RTN7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04135 ^@ http://purl.uniprot.org/uniprot/I1RJV2 ^@ Similarity ^@ Belongs to the AAR2 family. http://togogenome.org/gene/229533:FGSG_07104 ^@ http://purl.uniprot.org/uniprot/I1RSI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_07665 ^@ http://purl.uniprot.org/uniprot/I1RTZ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07445 ^@ http://purl.uniprot.org/uniprot/Q4I5R3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.|||Chromosome|||Component of the COMPASS (Set1C) complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_03857 ^@ http://purl.uniprot.org/uniprot/I1RJ54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00145 ^@ http://purl.uniprot.org/uniprot/I1R9K2 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09756 ^@ http://purl.uniprot.org/uniprot/I1RZC3 ^@ Similarity ^@ Belongs to the pex2/pex10/pex12 family. http://togogenome.org/gene/229533:FGSG_00070 ^@ http://purl.uniprot.org/uniprot/I1R9D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00906 ^@ http://purl.uniprot.org/uniprot/I1RBI1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/229533:FGSG_02325 ^@ http://purl.uniprot.org/uniprot/I1RF59 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the tpcK family.|||Dehydratase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).|||Impairs autofusarin biosynthesis and leads to the accumulation of the intermediate YWA1 (PubMed:21296881). http://togogenome.org/gene/229533:FGSG_00096 ^@ http://purl.uniprot.org/uniprot/I1R9F8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/229533:FGSG_06974 ^@ http://purl.uniprot.org/uniprot/I1RS61 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/229533:FGSG_00385 ^@ http://purl.uniprot.org/uniprot/Q4IQX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NHP6 family.|||Chromosome|||DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).|||Nucleus|||Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex. http://togogenome.org/gene/229533:FGSG_04247 ^@ http://purl.uniprot.org/uniprot/V6RAG6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_11228 ^@ http://purl.uniprot.org/uniprot/I1S360 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_06847 ^@ http://purl.uniprot.org/uniprot/V6REE9 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/229533:FGSG_09965 ^@ http://purl.uniprot.org/uniprot/I1RZV9 ^@ Similarity ^@ Belongs to the nucleoporin Nup133 family. http://togogenome.org/gene/229533:FGSG_11974 ^@ http://purl.uniprot.org/uniprot/I1S556 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_00561 ^@ http://purl.uniprot.org/uniprot/I1RAM9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_01495 ^@ http://purl.uniprot.org/uniprot/I1RD08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_06874 ^@ http://purl.uniprot.org/uniprot/I1RRX4 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/229533:FGSG_06270 ^@ http://purl.uniprot.org/uniprot/I1RQC9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/229533:FGSG_01498 ^@ http://purl.uniprot.org/uniprot/I1RD11 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/229533:FGSG_01164 ^@ http://purl.uniprot.org/uniprot/I1RC61 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/229533:FGSG_03136 ^@ http://purl.uniprot.org/uniprot/I1RH91 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/229533:FGSG_11469 ^@ http://purl.uniprot.org/uniprot/I1S3S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/229533:FGSG_03711 ^@ http://purl.uniprot.org/uniprot/I1RIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11805 ^@ http://purl.uniprot.org/uniprot/I1S4N7 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beclin family.|||Component of the autophagy-specific VPS34 PI3-kinase complex I; and of the VPS34 PI3-kinase complex II (By similarity).|||Endosome membrane|||Preautophagosomal structure membrane|||Required for cytoplasm to vacuole transport (Cvt), autophagy, nucleophagy, and mitophagy, as a part of the autophagy-specific VPS34 PI3-kinase complex I (By similarity). This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure (By similarity). Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).|||The C-terminal domain called the BARA domain is dispensable for the construction of both VPS34 PI3-kinase complexes, but is specifically required for autophagy through the targeting of complex I to the pre-autophagosomal structure (By similarity).|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_08464 ^@ http://purl.uniprot.org/uniprot/I1RW12 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_08477 ^@ http://purl.uniprot.org/uniprot/I1RW24 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/229533:FGSG_10636 ^@ http://purl.uniprot.org/uniprot/I1S1M9 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/229533:FGSG_00797 ^@ http://purl.uniprot.org/uniprot/I1RB88 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/229533:FGSG_09520 ^@ http://purl.uniprot.org/uniprot/I1RYR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_03694 ^@ http://purl.uniprot.org/uniprot/I1RIQ2 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/229533:FGSG_10860 ^@ http://purl.uniprot.org/uniprot/I1S274 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/229533:FGSG_11147 ^@ http://purl.uniprot.org/uniprot/I1S2Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05535 ^@ http://purl.uniprot.org/uniprot/I1RNF9 ^@ Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/229533:FGSG_07209 ^@ http://purl.uniprot.org/uniprot/V6RGQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09599 ^@ http://purl.uniprot.org/uniprot/V6RW66 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02485 ^@ http://purl.uniprot.org/uniprot/I1RFK6 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/229533:FGSG_10312 ^@ http://purl.uniprot.org/uniprot/I1S0S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01572 ^@ http://purl.uniprot.org/uniprot/I1RD80 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_04297 ^@ http://purl.uniprot.org/uniprot/I1RKA1 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PROPPIN family.|||Component of the PI(3,5)P2 regulatory complex (By similarity). Interacts with ATG2 and ATG9 (By similarity). The ATG2-ATG18 complex is essential for autophagosome formation (By similarity).|||Component of the PI(3,5)P2 regulatory complex that regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2) (By similarity). Plays an important role in osmotically-induced vacuole fragmentation (By similarity). Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy (By similarity). Involved in correct ATG9 trafficking to the pre-autophagosomal structure (By similarity). With ATG2, protects ATG8 from ATG4-mediated cleavage (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).|||Endosome membrane|||Preautophagosomal structure membrane|||The 377 first amino acids might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane (By similarity). Association to the membrane can also occur through binding to phosphatidylinositol 3-monophosphate (PI3P) (By similarity).|||The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions (By similarity).|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_03172 ^@ http://purl.uniprot.org/uniprot/I1RHC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/229533:FGSG_08531 ^@ http://purl.uniprot.org/uniprot/A0A1I9F923|||http://purl.uniprot.org/uniprot/Q4I2M7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family.|||Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Palmitoyltransferase specific for Ras proteins.|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/229533:FGSG_02426 ^@ http://purl.uniprot.org/uniprot/I1RFF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/229533:FGSG_10888 ^@ http://purl.uniprot.org/uniprot/I1S2A2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01997 ^@ http://purl.uniprot.org/uniprot/I1REB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08349 ^@ http://purl.uniprot.org/uniprot/I1RVR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03775 ^@ http://purl.uniprot.org/uniprot/I1RIX8 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_09060 ^@ http://purl.uniprot.org/uniprot/I1RXI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01382 ^@ http://purl.uniprot.org/uniprot/I1RCQ7 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_03328 ^@ http://purl.uniprot.org/uniprot/I1RHR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_05181 ^@ http://purl.uniprot.org/uniprot/I1RMJ1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/229533:FGSG_08392 ^@ http://purl.uniprot.org/uniprot/I1RVU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11810 ^@ http://purl.uniprot.org/uniprot/I1S4P2 ^@ Similarity ^@ Belongs to the PPP4R2 family. http://togogenome.org/gene/229533:FGSG_01276 ^@ http://purl.uniprot.org/uniprot/I1RCG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/229533:FGSG_10612 ^@ http://purl.uniprot.org/uniprot/I1S1K5 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_00874 ^@ http://purl.uniprot.org/uniprot/A0A1I9EWU4|||http://purl.uniprot.org/uniprot/Q4IPI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family.|||Belongs to the actin family. ARP4 subfamily.|||Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_07222 ^@ http://purl.uniprot.org/uniprot/I1RST8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_10769 ^@ http://purl.uniprot.org/uniprot/V6RVG3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_03118 ^@ http://purl.uniprot.org/uniprot/I1RH73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05236 ^@ http://purl.uniprot.org/uniprot/V6R9T8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion.|||Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_05550 ^@ http://purl.uniprot.org/uniprot/I1RNH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/229533:FGSG_02286 ^@ http://purl.uniprot.org/uniprot/I1RF23 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_00745 ^@ http://purl.uniprot.org/uniprot/I1RB40 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/229533:FGSG_07280 ^@ http://purl.uniprot.org/uniprot/I1RSZ3 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/229533:FGSG_01334 ^@ http://purl.uniprot.org/uniprot/I1RCL5 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/229533:FGSG_05809 ^@ http://purl.uniprot.org/uniprot/I1RP57 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/229533:FGSG_01111 ^@ http://purl.uniprot.org/uniprot/I1RC11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/229533:FGSG_12335 ^@ http://purl.uniprot.org/uniprot/I1S664 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07379 ^@ http://purl.uniprot.org/uniprot/I1RT80 ^@ Similarity ^@ Belongs to the WD repeat PWP2 family. http://togogenome.org/gene/229533:FGSG_09299 ^@ http://purl.uniprot.org/uniprot/I1RY62 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/229533:FGSG_02229 ^@ http://purl.uniprot.org/uniprot/I1REX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05404 ^@ http://purl.uniprot.org/uniprot/I1RN41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LU7TM family.|||Membrane http://togogenome.org/gene/229533:FGSG_11729 ^@ http://purl.uniprot.org/uniprot/I1S4G2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/229533:FGSG_05605 ^@ http://purl.uniprot.org/uniprot/I1RNM2 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit. http://togogenome.org/gene/229533:FGSG_00739 ^@ http://purl.uniprot.org/uniprot/I1RB34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10293 ^@ http://purl.uniprot.org/uniprot/I1S0Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06951 ^@ http://purl.uniprot.org/uniprot/I1RS43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic GTase family.|||Heterodimer.|||Nucleus|||Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate. http://togogenome.org/gene/229533:FGSG_06315 ^@ http://purl.uniprot.org/uniprot/I1RQH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_03448 ^@ http://purl.uniprot.org/uniprot/I1RI27 ^@ Function|||Similarity|||Subunit ^@ Associates with the respiratory chain complex III/complex IV supercomplex.|||Belongs to the RCF1 family.|||Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes. http://togogenome.org/gene/229533:FGSG_05949 ^@ http://purl.uniprot.org/uniprot/I1RPI0 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/229533:FGSG_04487 ^@ http://purl.uniprot.org/uniprot/I1RKS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07643 ^@ http://purl.uniprot.org/uniprot/I1RTX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_13737 ^@ http://purl.uniprot.org/uniprot/I1SA56 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02533 ^@ http://purl.uniprot.org/uniprot/I1RFP9 ^@ Similarity ^@ Belongs to the PRP18 family. http://togogenome.org/gene/229533:FGSG_07191 ^@ http://purl.uniprot.org/uniprot/I1RSR0 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/229533:FGSG_06572 ^@ http://purl.uniprot.org/uniprot/I1RR60 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_05015 ^@ http://purl.uniprot.org/uniprot/I1RM37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP25 family.|||Mitochondrial mRNA stabilization factor.|||Mitochondrion inner membrane|||Probable mitochondrial mRNA stabilization factor. http://togogenome.org/gene/229533:FGSG_01362 ^@ http://purl.uniprot.org/uniprot/I1RCN9 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the velvet family. VelB subfamily.|||Component of the heterotrimeric velvet complex composed of laeA, veA and velB; VeA acting as a bridging protein between laeA and velB (By similarity). Forms a heterodimeric complex with vosA; the formation of the velB-vosA complex is light-dependent (By similarity).|||Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex acts as a global regulator for secondary metabolite gene expression (By similarity). Component of the velB-VosA heterodimeric complex that plays a dual role in activating genes associated with spore maturation and repressing certain development-associated genes (By similarity). The complex binds DNA through the DNA-binding domain of vosA that recognizes an 11-nucleotide consensus sequence 5'-CTGGCCGCGGC-3' consisting of two motifs in the promoters of key developmental regulatory genes (By similarity). Controls the expression of the pink pigment aurofusarin and the mycotoxin deoxynivalenol gene clusters (PubMed:22713714). Regulates hyphae formation, hyphal hydrophobicity and conidiation (PubMed:22713714). Regulates of cell wall integrity and pathogenicity (PubMed:22713714).|||Cytoplasm|||Exhibits reduced pink pigment formation, but increased yellow pigment production (PubMed:22713714). Down-regulates the six genes involved in biosynthesis of the pink pigment aurofusarin (PubMed:22713714). Down-regulates also the genes involved in the mycotoxin deoxynivalenol biosynthesis (PubMed:22713714). Suppresses of aerial hyphae formation, reduces hyphal hydrophobicity and highly increases conidiation (PubMed:22713714). Impaired virulence on flowering wheat head (PubMed:22713714).|||Nucleus http://togogenome.org/gene/229533:FGSG_05447 ^@ http://purl.uniprot.org/uniprot/I1RN81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/229533:FGSG_11417 ^@ http://purl.uniprot.org/uniprot/I1S3M7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00399 ^@ http://purl.uniprot.org/uniprot/I1RA73 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03194 ^@ http://purl.uniprot.org/uniprot/I1RHE5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_07180 ^@ http://purl.uniprot.org/uniprot/I1RSQ2 ^@ Similarity ^@ Belongs to the protein disulfide isomerase family. http://togogenome.org/gene/229533:FGSG_06736 ^@ http://purl.uniprot.org/uniprot/I1RRK8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM34 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and FG06736.1.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. FG06736.1 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.|||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_02273 ^@ http://purl.uniprot.org/uniprot/V6R0F7 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06688 ^@ http://purl.uniprot.org/uniprot/I1RRG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/229533:FGSG_03813 ^@ http://purl.uniprot.org/uniprot/I1RJ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 54 family.|||Secreted http://togogenome.org/gene/229533:FGSG_01270 ^@ http://purl.uniprot.org/uniprot/I1RCF6 ^@ Similarity ^@ Belongs to the OPA3 family. http://togogenome.org/gene/229533:FGSG_05436 ^@ http://purl.uniprot.org/uniprot/I1RN70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/229533:FGSG_13172 ^@ http://purl.uniprot.org/uniprot/I1S8J4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12505 ^@ http://purl.uniprot.org/uniprot/I1S6N2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04927 ^@ http://purl.uniprot.org/uniprot/I1RLV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion inner membrane|||Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. http://togogenome.org/gene/229533:FGSG_01059 ^@ http://purl.uniprot.org/uniprot/A0A1I9EXJ3|||http://purl.uniprot.org/uniprot/Q4INZ9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.|||Binds to histones H3 and H4.|||Inhibited by both FK506 and rapamycin.|||Nucleus|||PPIase that acts as a histone chaperone. Histone proline isomerase that increases the rate of cis-trans isomerization at prolines on the histone H3 N-terminal tail. Proline isomerization influences H3 methylation thereby regulating gene expression. http://togogenome.org/gene/229533:FGSG_08901 ^@ http://purl.uniprot.org/uniprot/I1RX51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC24 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/229533:FGSG_11081 ^@ http://purl.uniprot.org/uniprot/I1S2S8 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_02143 ^@ http://purl.uniprot.org/uniprot/V6QYV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02352 ^@ http://purl.uniprot.org/uniprot/I1RF85 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/229533:FGSG_01450 ^@ http://purl.uniprot.org/uniprot/I1RCW7 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/229533:FGSG_09964 ^@ http://purl.uniprot.org/uniprot/I1RZV8 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/229533:FGSG_03466 ^@ http://purl.uniprot.org/uniprot/I1RI43 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/229533:FGSG_03716 ^@ http://purl.uniprot.org/uniprot/I1RIS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06945 ^@ http://purl.uniprot.org/uniprot/I1RS38 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization.|||Component of the PAN1 actin cytoskeleton-regulatory complex.|||Endosome membrane|||Membrane|||actin patch http://togogenome.org/gene/229533:FGSG_09307 ^@ http://purl.uniprot.org/uniprot/I1RY70 ^@ Function|||Similarity ^@ Belongs to the KAR5 family.|||Required for nuclear membrane fusion during karyogamy. http://togogenome.org/gene/229533:FGSG_00369 ^@ http://purl.uniprot.org/uniprot/I1RA45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/229533:FGSG_01154 ^@ http://purl.uniprot.org/uniprot/I1RC51 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/229533:FGSG_11270 ^@ http://purl.uniprot.org/uniprot/I1S395 ^@ Similarity|||Subunit ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.|||Homotetramer. http://togogenome.org/gene/229533:FGSG_00398 ^@ http://purl.uniprot.org/uniprot/Q4IQW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM34 family.|||Involved in pre-25S rRNA processing.|||nucleolus http://togogenome.org/gene/229533:FGSG_00323 ^@ http://purl.uniprot.org/uniprot/I1RA06 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/229533:FGSG_07423 ^@ http://purl.uniprot.org/uniprot/I1RTC2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/229533:FGSG_02920 ^@ http://purl.uniprot.org/uniprot/I1RGP7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/229533:FGSG_01946 ^@ http://purl.uniprot.org/uniprot/I1RE69 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_06330 ^@ http://purl.uniprot.org/uniprot/I1RQI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/229533:FGSG_00573 ^@ http://purl.uniprot.org/uniprot/I1RAP1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09025 ^@ http://purl.uniprot.org/uniprot/I1RXF8 ^@ Similarity ^@ Belongs to the helicase family. Dicer subfamily. http://togogenome.org/gene/229533:FGSG_00350 ^@ http://purl.uniprot.org/uniprot/A0A1I9EV29|||http://purl.uniprot.org/uniprot/Q4IR08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ASF1 family.|||Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.|||Interacts with histone H3 and histone H4.|||Nucleus http://togogenome.org/gene/229533:FGSG_11113 ^@ http://purl.uniprot.org/uniprot/I1S2V9 ^@ Cofactor ^@ Binds 2 manganese ions per subunit. http://togogenome.org/gene/229533:FGSG_02541 ^@ http://purl.uniprot.org/uniprot/V6R042 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/229533:FGSG_06425 ^@ http://purl.uniprot.org/uniprot/I1RQS6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02625 ^@ http://purl.uniprot.org/uniprot/I1RFY1 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/229533:FGSG_10105 ^@ http://purl.uniprot.org/uniprot/I1S087 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSH4 family.|||Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.|||Endosome membrane|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_04217 ^@ http://purl.uniprot.org/uniprot/I1RK29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05689 ^@ http://purl.uniprot.org/uniprot/I1RNU7 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_09740 ^@ http://purl.uniprot.org/uniprot/A0A1I9FI99|||http://purl.uniprot.org/uniprot/Q4HZ68 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.|||Present with 1460 molecules/cell in log phase SD medium.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_00358 ^@ http://purl.uniprot.org/uniprot/I1RA36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/229533:FGSG_02699 ^@ http://purl.uniprot.org/uniprot/I1RG50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.|||Membrane http://togogenome.org/gene/229533:FGSG_07439 ^@ http://purl.uniprot.org/uniprot/A0A1I9FLZ5|||http://purl.uniprot.org/uniprot/Q4I5R9 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIase B subfamily.|||Endoplasmic reticulum lumen|||Inhibited by cyclosporin A (CsA).|||Lacks the C-terminal transmembrane domain, but has an ER retention motif at its extreme C-terminus.|||Membrane|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_02079 ^@ http://purl.uniprot.org/uniprot/I1REJ0 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_03632 ^@ http://purl.uniprot.org/uniprot/I1RIJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_05405 ^@ http://purl.uniprot.org/uniprot/I1RN42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06477 ^@ http://purl.uniprot.org/uniprot/I1RQX6 ^@ Similarity ^@ Belongs to the scytalone dehydratase family. http://togogenome.org/gene/229533:FGSG_01062 ^@ http://purl.uniprot.org/uniprot/I1RBX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06612 ^@ http://purl.uniprot.org/uniprot/I1RR96 ^@ Cofactor ^@ Binds 2 manganese ions per subunit. http://togogenome.org/gene/229533:FGSG_05701 ^@ http://purl.uniprot.org/uniprot/I1RNV9 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/229533:FGSG_01053 ^@ http://purl.uniprot.org/uniprot/I1RBW2 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/229533:FGSG_07787 ^@ http://purl.uniprot.org/uniprot/I1RUA2 ^@ Similarity ^@ Belongs to the Necrosis inducing protein (NPP1) family. http://togogenome.org/gene/229533:FGSG_11408 ^@ http://purl.uniprot.org/uniprot/I1S3L9 ^@ Similarity ^@ Belongs to the tpcK family. http://togogenome.org/gene/229533:FGSG_02769 ^@ http://purl.uniprot.org/uniprot/I1RGB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_09245 ^@ http://purl.uniprot.org/uniprot/I1RY16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the iron-containing alcohol dehydrogenase family. Hydroxyacid-oxoacid transhydrogenase subfamily.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_09842 ^@ http://purl.uniprot.org/uniprot/I1RZJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of a fungal signal recognition particle (SRP) complex that consists of a 7SL RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_00091 ^@ http://purl.uniprot.org/uniprot/I1R9F3 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_06868 ^@ http://purl.uniprot.org/uniprot/I1RRW8 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_10712 ^@ http://purl.uniprot.org/uniprot/I1S1U2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_03174 ^@ http://purl.uniprot.org/uniprot/I1RHC8 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/229533:FGSG_08462 ^@ http://purl.uniprot.org/uniprot/I1RW10 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_04030 ^@ http://purl.uniprot.org/uniprot/Q4IFH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HIR3 family.|||Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.|||Nucleus http://togogenome.org/gene/229533:FGSG_03044 ^@ http://purl.uniprot.org/uniprot/I1RH09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10041 ^@ http://purl.uniprot.org/uniprot/I1S027 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/229533:FGSG_00833 ^@ http://purl.uniprot.org/uniprot/I1RBC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.|||Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.|||Endoplasmic reticulum membrane http://togogenome.org/gene/229533:FGSG_02367 ^@ http://purl.uniprot.org/uniprot/I1RF98 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00887 ^@ http://purl.uniprot.org/uniprot/I1RBG5 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/229533:FGSG_08023 ^@ http://purl.uniprot.org/uniprot/I1RUW5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_10040 ^@ http://purl.uniprot.org/uniprot/A0A1I9F419|||http://purl.uniprot.org/uniprot/Q4HYB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.|||Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).|||Nucleus http://togogenome.org/gene/229533:FGSG_06596 ^@ http://purl.uniprot.org/uniprot/I1RR82 ^@ Similarity ^@ Belongs to the catalase family. http://togogenome.org/gene/229533:FGSG_04537 ^@ http://purl.uniprot.org/uniprot/I1RKW6 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_02783 ^@ http://purl.uniprot.org/uniprot/I1RGC4 ^@ Function|||Induction|||Miscellaneous|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG6A and ERG6B methylate lanosterol at C-24 to produce eburicol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_10267 ^@ http://purl.uniprot.org/uniprot/I1S0N3 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/229533:FGSG_02496 ^@ http://purl.uniprot.org/uniprot/I1RFL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_13357 ^@ http://purl.uniprot.org/uniprot/I1S927 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_08492 ^@ http://purl.uniprot.org/uniprot/I1RW38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STAM family.|||Component of the ESCRT-0 complex composed of HSE1 and VPS27.|||Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).|||Endosome membrane|||Membrane http://togogenome.org/gene/229533:FGSG_05545 ^@ http://purl.uniprot.org/uniprot/A0A1I9FTQ3|||http://purl.uniprot.org/uniprot/Q4IB63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family. PIGB subfamily.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity).|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/229533:FGSG_05983 ^@ http://purl.uniprot.org/uniprot/I1RPL0 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_06645 ^@ http://purl.uniprot.org/uniprot/I1RRC7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PLPL family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lipid hydrolase.|||Membrane|||Probable lipid hydrolase. http://togogenome.org/gene/229533:FGSG_00039 ^@ http://purl.uniprot.org/uniprot/I1R9A8 ^@ Function ^@ Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_02531 ^@ http://purl.uniprot.org/uniprot/I1RFP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03737 ^@ http://purl.uniprot.org/uniprot/I1RIU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02026 ^@ http://purl.uniprot.org/uniprot/A0A1I9F0S0|||http://purl.uniprot.org/uniprot/Q4IL82 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/229533:FGSG_09158 ^@ http://purl.uniprot.org/uniprot/I1RXT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05330 ^@ http://purl.uniprot.org/uniprot/I1RMX6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/229533:FGSG_06027 ^@ http://purl.uniprot.org/uniprot/I1RPQ1 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/229533:FGSG_00085 ^@ http://purl.uniprot.org/uniprot/I1R9E9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09761 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQ50|||http://purl.uniprot.org/uniprot/Q4HZ47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).|||Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2.|||nucleolus http://togogenome.org/gene/229533:FGSG_03212 ^@ http://purl.uniprot.org/uniprot/I1RHG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Secreted http://togogenome.org/gene/229533:FGSG_02058 ^@ http://purl.uniprot.org/uniprot/I1REG9 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/229533:FGSG_00638 ^@ http://purl.uniprot.org/uniprot/I1RAV0 ^@ Similarity ^@ Belongs to the HMG-CoA lyase family. http://togogenome.org/gene/229533:FGSG_07093 ^@ http://purl.uniprot.org/uniprot/I1RSH4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/229533:FGSG_03838 ^@ http://purl.uniprot.org/uniprot/I1RJ39 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02287 ^@ http://purl.uniprot.org/uniprot/I1RF24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/229533:FGSG_02071 ^@ http://purl.uniprot.org/uniprot/I1REI2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/229533:FGSG_13906 ^@ http://purl.uniprot.org/uniprot/I1SAM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_05226 ^@ http://purl.uniprot.org/uniprot/I1RMN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_06157 ^@ http://purl.uniprot.org/uniprot/I1RQ24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09850 ^@ http://purl.uniprot.org/uniprot/I1RZK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events.|||Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/229533:FGSG_10884 ^@ http://purl.uniprot.org/uniprot/I1S298 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/229533:FGSG_00912 ^@ http://purl.uniprot.org/uniprot/I1RBI7 ^@ Similarity ^@ Belongs to the TMCO4 family. http://togogenome.org/gene/229533:FGSG_07839 ^@ http://purl.uniprot.org/uniprot/I1RUE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_02169 ^@ http://purl.uniprot.org/uniprot/I1RER9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_10203 ^@ http://purl.uniprot.org/uniprot/I1S0H5 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/229533:FGSG_09232 ^@ http://purl.uniprot.org/uniprot/I1RY04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04433 ^@ http://purl.uniprot.org/uniprot/I1RKM2 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_09594 ^@ http://purl.uniprot.org/uniprot/I1RYY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07894 ^@ http://purl.uniprot.org/uniprot/V6RJ21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06074 ^@ http://purl.uniprot.org/uniprot/I1RPU4 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/229533:FGSG_10280 ^@ http://purl.uniprot.org/uniprot/I1S0P4 ^@ Similarity ^@ Belongs to the WD repeat rae1 family. http://togogenome.org/gene/229533:FGSG_07161 ^@ http://purl.uniprot.org/uniprot/I1RSN5 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/229533:FGSG_02031 ^@ http://purl.uniprot.org/uniprot/I1REE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06542 ^@ http://purl.uniprot.org/uniprot/Q4I8B6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Early endosome membrane|||Golgi apparatus membrane|||Palmitoyltransferase specific for casein kinase 1.|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/229533:FGSG_07744 ^@ http://purl.uniprot.org/uniprot/I1RU61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00306 ^@ http://purl.uniprot.org/uniprot/I1R9Y9 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/229533:FGSG_12711 ^@ http://purl.uniprot.org/uniprot/I1S788 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.|||telomere http://togogenome.org/gene/229533:FGSG_02091 ^@ http://purl.uniprot.org/uniprot/I1REK2 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/229533:FGSG_08797 ^@ http://purl.uniprot.org/uniprot/I1RWW1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/229533:FGSG_11289 ^@ http://purl.uniprot.org/uniprot/I1S3B3 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/229533:FGSG_10464 ^@ http://purl.uniprot.org/uniprot/I1S166 ^@ Cofactor|||Disruption Phenotype|||Domain|||Function|||Induction ^@ Binds 1 phosphopantetheine covalently.|||Expressed during sexual development (PubMed:16278459). Is not expressed during infection of wheat plants (PubMed:23290226). Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes (PubMed:22252016).|||Leads to significant increase in growth (PubMed:16278459). Abolishes the production of fusarielins F, G and H (PubMed:22252016, PubMed:27983606).|||Multidomain protein; including a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a dehydratase (DH) domain that reduces hydroxyl groups to enoyl groups; a methyltransferase (MET) domain that transfers methyl groups to the growing polyketide; a ketoreductase (KR) domain that catalyzes beta-ketoreduction steps; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (Probable). Lacks an active enoyl reductase (ER) domain that reduces enoyl groups to alkyl groups, and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5 (Probable).|||Reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by the cytochrome P450 monooxygenase FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606). http://togogenome.org/gene/229533:FGSG_08150 ^@ http://purl.uniprot.org/uniprot/I1RV85 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/229533:FGSG_13881 ^@ http://purl.uniprot.org/uniprot/I1SAK0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_00590 ^@ http://purl.uniprot.org/uniprot/I1RAQ5 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/229533:FGSG_08299 ^@ http://purl.uniprot.org/uniprot/I1RVL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/229533:FGSG_11123 ^@ http://purl.uniprot.org/uniprot/I1S2W7 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_07587 ^@ http://purl.uniprot.org/uniprot/I1RTS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01665 ^@ http://purl.uniprot.org/uniprot/I1RDG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/229533:FGSG_08884 ^@ http://purl.uniprot.org/uniprot/I1RX35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10188 ^@ http://purl.uniprot.org/uniprot/I1S0G2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_00416 ^@ http://purl.uniprot.org/uniprot/I1RA89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Nitrate/nitrite porter (TC 2.A.1.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_13014 ^@ http://purl.uniprot.org/uniprot/I1S838 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/229533:FGSG_06936 ^@ http://purl.uniprot.org/uniprot/I1RS29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00166 ^@ http://purl.uniprot.org/uniprot/I1R9L9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_03229 ^@ http://purl.uniprot.org/uniprot/I1RHH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04311 ^@ http://purl.uniprot.org/uniprot/I1RKB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09828 ^@ http://purl.uniprot.org/uniprot/I1RZI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_03858 ^@ http://purl.uniprot.org/uniprot/I1RJ55 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_05255 ^@ http://purl.uniprot.org/uniprot/I1RMR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07918 ^@ http://purl.uniprot.org/uniprot/I1RUL9 ^@ Similarity ^@ Belongs to the paraoxonase family. http://togogenome.org/gene/229533:FGSG_03919 ^@ http://purl.uniprot.org/uniprot/I1RJB0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05766 ^@ http://purl.uniprot.org/uniprot/I1RP18 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/229533:FGSG_05370 ^@ http://purl.uniprot.org/uniprot/I1RN12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10571 ^@ http://purl.uniprot.org/uniprot/I1S1H0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_10998 ^@ http://purl.uniprot.org/uniprot/I1S2K2 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Binds 1 FAD per subunit in a bicovalent manner.|||Catalyzes the selective oxidation of C1 hydroxyl moieties on chitooligosaccharides with concomitant reduction of molecular oxygen to hydrogen peroxide. This results in the formation of the corresponding lactones, which typically undergo spontaneous hydrolysis. Chitooligosaccharides are homo- or heterooligomers of N-acetylglucosamine (GlcNAc) and D-glucosamine which are linked through beta-1,4-glycosidic bonds. For optimal substrate binding at least 2 GlcNAc units are needed, and chitooligosaccharide oxidase is most efficient on chitobiose, chitotriose and chitotetraose.|||Secreted|||The FAD cofactor is bound via a bicovalent 6-S-cysteinyl, 8alpha-N1-histidyl FAD linkage. http://togogenome.org/gene/229533:FGSG_08446 ^@ http://purl.uniprot.org/uniprot/A0A1I9F6J6|||http://purl.uniprot.org/uniprot/Q4I2W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_00960 ^@ http://purl.uniprot.org/uniprot/I1RBN0 ^@ Function ^@ Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/229533:FGSG_00620 ^@ http://purl.uniprot.org/uniprot/I1RAT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_03626 ^@ http://purl.uniprot.org/uniprot/I1RII9 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_09363 ^@ http://purl.uniprot.org/uniprot/I1RYB9 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/229533:FGSG_06792 ^@ http://purl.uniprot.org/uniprot/I1RRQ7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/229533:FGSG_03271 ^@ http://purl.uniprot.org/uniprot/I1RHL2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00645 ^@ http://purl.uniprot.org/uniprot/I1RAV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/229533:FGSG_01216 ^@ http://purl.uniprot.org/uniprot/I1RCB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPL4 family.|||Endoplasmic reticulum membrane|||Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway.|||Membrane|||Nucleus membrane|||perinuclear region http://togogenome.org/gene/229533:FGSG_03078 ^@ http://purl.uniprot.org/uniprot/I1RH37 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/229533:FGSG_10310 ^@ http://purl.uniprot.org/uniprot/I1S0S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05394 ^@ http://purl.uniprot.org/uniprot/I1RN32 ^@ Similarity ^@ Belongs to the taffazin family. http://togogenome.org/gene/229533:FGSG_05035 ^@ http://purl.uniprot.org/uniprot/I1RM54 ^@ Similarity ^@ Belongs to the PdxS/SNZ family. http://togogenome.org/gene/229533:FGSG_00447 ^@ http://purl.uniprot.org/uniprot/I1RAC0 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/229533:FGSG_09935 ^@ http://purl.uniprot.org/uniprot/I1RZT1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_00880 ^@ http://purl.uniprot.org/uniprot/I1RBG0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05614 ^@ http://purl.uniprot.org/uniprot/I1RNN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit H family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_10815 ^@ http://purl.uniprot.org/uniprot/I1S232 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/229533:FGSG_07074 ^@ http://purl.uniprot.org/uniprot/I1RSF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04213 ^@ http://purl.uniprot.org/uniprot/I1RK25 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/229533:FGSG_06733 ^@ http://purl.uniprot.org/uniprot/I1RRK5 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/229533:FGSG_03024 ^@ http://purl.uniprot.org/uniprot/I1RGZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06893 ^@ http://purl.uniprot.org/uniprot/I1RRY9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/229533:FGSG_06865 ^@ http://purl.uniprot.org/uniprot/V6RM66 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion.|||Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_05493 ^@ http://purl.uniprot.org/uniprot/I1RNC1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/229533:FGSG_08964 ^@ http://purl.uniprot.org/uniprot/V6RNA1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits. http://togogenome.org/gene/229533:FGSG_12747 ^@ http://purl.uniprot.org/uniprot/I1S7C4 ^@ Similarity ^@ Belongs to the PrpF family. http://togogenome.org/gene/229533:FGSG_07608 ^@ http://purl.uniprot.org/uniprot/I1RTU1 ^@ Similarity ^@ Belongs to the SurE nucleotidase family. http://togogenome.org/gene/229533:FGSG_00083 ^@ http://purl.uniprot.org/uniprot/I1R9E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07953 ^@ http://purl.uniprot.org/uniprot/I1RUQ3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02494 ^@ http://purl.uniprot.org/uniprot/A0A1I9F1Z0|||http://purl.uniprot.org/uniprot/Q4IJW4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/229533:FGSG_00541 ^@ http://purl.uniprot.org/uniprot/I1RAL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08778 ^@ http://purl.uniprot.org/uniprot/V6RRF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/229533:FGSG_03628 ^@ http://purl.uniprot.org/uniprot/I1RIJ1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase family 6. http://togogenome.org/gene/229533:FGSG_05271 ^@ http://purl.uniprot.org/uniprot/I1RMS4 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/229533:FGSG_07838 ^@ http://purl.uniprot.org/uniprot/I1RUE8 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_07012 ^@ http://purl.uniprot.org/uniprot/I1RS98 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10137 ^@ http://purl.uniprot.org/uniprot/I1S0B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/229533:FGSG_06628 ^@ http://purl.uniprot.org/uniprot/A0A1I9FLS8|||http://purl.uniprot.org/uniprot/Q4I830 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in ribosome assembly.|||Associates with pre-ribosomal particles.|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_02518 ^@ http://purl.uniprot.org/uniprot/Q4IJU0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).|||Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).|||In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.|||Nucleus http://togogenome.org/gene/229533:FGSG_00485 ^@ http://purl.uniprot.org/uniprot/I1RAF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_09373 ^@ http://purl.uniprot.org/uniprot/I1RYC8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Binds 1 FAD per monomer.|||Irreversibly catalyzes the reduction of fumarate to succinate. http://togogenome.org/gene/229533:FGSG_04361 ^@ http://purl.uniprot.org/uniprot/I1RKF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_09748 ^@ http://purl.uniprot.org/uniprot/I1RZB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02571 ^@ http://purl.uniprot.org/uniprot/I1RFT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_09849 ^@ http://purl.uniprot.org/uniprot/I1RZK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08596 ^@ http://purl.uniprot.org/uniprot/I1RWD2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02687 ^@ http://purl.uniprot.org/uniprot/I1RG38 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_07150 ^@ http://purl.uniprot.org/uniprot/I1RSM4 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/229533:FGSG_01403 ^@ http://purl.uniprot.org/uniprot/I1RCS6 ^@ Similarity ^@ Belongs to the WrbA family. http://togogenome.org/gene/229533:FGSG_00302 ^@ http://purl.uniprot.org/uniprot/I1R9Y6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09016 ^@ http://purl.uniprot.org/uniprot/I1RXF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/229533:FGSG_04930 ^@ http://purl.uniprot.org/uniprot/I1RLW0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_01392 ^@ http://purl.uniprot.org/uniprot/I1RCR6 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/229533:FGSG_02346 ^@ http://purl.uniprot.org/uniprot/I1RF79 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Delta(14)-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:21436218). Catalyzes the reduction of the C14=C15 double bond within 4,4,24-trimethyl ergosta-8,14,24(28)-trienolto produce 4,4-dimethylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||Exhibits significantly increased sensitivity to amine fungicides, including tridemorph, fenpropidin and spiroxamine, but not to non-amine fungicides.|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol. http://togogenome.org/gene/229533:FGSG_10619 ^@ http://purl.uniprot.org/uniprot/I1S1L2 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_10368 ^@ http://purl.uniprot.org/uniprot/I1S0X6 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit. http://togogenome.org/gene/229533:FGSG_04251 ^@ http://purl.uniprot.org/uniprot/I1RK61 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00496 ^@ http://purl.uniprot.org/uniprot/I1RAG8 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/229533:FGSG_06545 ^@ http://purl.uniprot.org/uniprot/I1RR36 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_04953 ^@ http://purl.uniprot.org/uniprot/I1RLY2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_04840 ^@ http://purl.uniprot.org/uniprot/I1RLN0 ^@ Similarity ^@ Belongs to the peptidase C14B family. http://togogenome.org/gene/229533:FGSG_01710 ^@ http://purl.uniprot.org/uniprot/A0A1I9EZP1|||http://purl.uniprot.org/uniprot/Q4IM48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||Probable transporter.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_10905 ^@ http://purl.uniprot.org/uniprot/V6RTJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.|||Cytoplasm|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. http://togogenome.org/gene/229533:FGSG_00765 ^@ http://purl.uniprot.org/uniprot/I1RB58 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00338 ^@ http://purl.uniprot.org/uniprot/I1RA21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09400 ^@ http://purl.uniprot.org/uniprot/V6RNC7 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/229533:FGSG_07716 ^@ http://purl.uniprot.org/uniprot/I1RU37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10914 ^@ http://purl.uniprot.org/uniprot/I1S2C5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01133 ^@ http://purl.uniprot.org/uniprot/I1RC31 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. http://togogenome.org/gene/229533:FGSG_04717 ^@ http://purl.uniprot.org/uniprot/I1RLC6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09696 ^@ http://purl.uniprot.org/uniprot/I1RZ70 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00336 ^@ http://purl.uniprot.org/uniprot/I1RA19 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/229533:FGSG_11656 ^@ http://purl.uniprot.org/uniprot/I1S489 ^@ Function|||Similarity|||Subunit ^@ Belongs to the fungal fatty acid synthetase subunit beta family.|||Fatty acid synthase subunit beta; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).|||[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta). http://togogenome.org/gene/229533:FGSG_00924 ^@ http://purl.uniprot.org/uniprot/I1RBJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00446 ^@ http://purl.uniprot.org/uniprot/I1RAB9 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/229533:FGSG_13006 ^@ http://purl.uniprot.org/uniprot/I1S830 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/229533:FGSG_06115 ^@ http://purl.uniprot.org/uniprot/I1RPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/229533:FGSG_06037 ^@ http://purl.uniprot.org/uniprot/I1RPQ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/229533:FGSG_01656 ^@ http://purl.uniprot.org/uniprot/I1RDG0 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/229533:FGSG_06858 ^@ http://purl.uniprot.org/uniprot/I1RRW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_05789 ^@ http://purl.uniprot.org/uniprot/I1RP37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12397 ^@ http://purl.uniprot.org/uniprot/I1S6C6 ^@ Similarity ^@ Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_04329 ^@ http://purl.uniprot.org/uniprot/I1RKC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the peroxisomal translocation machinery.|||Peroxisome membrane http://togogenome.org/gene/229533:FGSG_06137 ^@ http://purl.uniprot.org/uniprot/I1RQ05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09983 ^@ http://purl.uniprot.org/uniprot/I1RZX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ODC antizyme family.|||Interacts with ODC and thereby sterically blocks ODC homodimerization.|||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. http://togogenome.org/gene/229533:FGSG_08453 ^@ http://purl.uniprot.org/uniprot/I1RW01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/229533:FGSG_05082 ^@ http://purl.uniprot.org/uniprot/I1RM97 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02341 ^@ http://purl.uniprot.org/uniprot/I1RF75 ^@ Similarity ^@ Belongs to the chloroperoxidase family. http://togogenome.org/gene/229533:FGSG_01885 ^@ http://purl.uniprot.org/uniprot/I1RE13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02589 ^@ http://purl.uniprot.org/uniprot/I1RFU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07784 ^@ http://purl.uniprot.org/uniprot/I1RU99 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_11394 ^@ http://purl.uniprot.org/uniprot/I1S3K6 ^@ Function|||Similarity ^@ Belongs to the peptidase C26 family.|||Glutamine amidotransferase-like protein; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable). http://togogenome.org/gene/229533:FGSG_06464 ^@ http://purl.uniprot.org/uniprot/I1RQW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01685 ^@ http://purl.uniprot.org/uniprot/I1RDI6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/229533:FGSG_08897 ^@ http://purl.uniprot.org/uniprot/I1RX47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/229533:FGSG_09028 ^@ http://purl.uniprot.org/uniprot/I1RXG0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_03349 ^@ http://purl.uniprot.org/uniprot/I1RHT5 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_04064 ^@ http://purl.uniprot.org/uniprot/V6R378 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_03512 ^@ http://purl.uniprot.org/uniprot/V6R645 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08694 ^@ http://purl.uniprot.org/uniprot/V6RK56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Mitochondrion membrane http://togogenome.org/gene/229533:FGSG_01528 ^@ http://purl.uniprot.org/uniprot/I1RD39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09722 ^@ http://purl.uniprot.org/uniprot/I1RZ92 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IPP isomerase type 1 family.|||Binds 1 Mg(2+) ion per subunit.|||Isopentenyl-diphosphate delta-isomerase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). IDI1 catalyzes the 1,3-allylic rearrangement of isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable). http://togogenome.org/gene/229533:FGSG_03731 ^@ http://purl.uniprot.org/uniprot/I1RIT7 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_03999 ^@ http://purl.uniprot.org/uniprot/I1RJH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_01986 ^@ http://purl.uniprot.org/uniprot/I1REA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13128 ^@ http://purl.uniprot.org/uniprot/I1S8F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_09659 ^@ http://purl.uniprot.org/uniprot/I1RZ36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHE9 family.|||Homooligomer.|||Mitochondrion inner membrane|||Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed. http://togogenome.org/gene/229533:FGSG_01909 ^@ http://purl.uniprot.org/uniprot/I1RE36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPC1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_09191 ^@ http://purl.uniprot.org/uniprot/I1RXW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05508 ^@ http://purl.uniprot.org/uniprot/I1RND5 ^@ Function|||Similarity ^@ Belongs to the CWC15 family.|||Involved in pre-mRNA splicing. http://togogenome.org/gene/229533:FGSG_00743 ^@ http://purl.uniprot.org/uniprot/I1RB38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CybS family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_13493 ^@ http://purl.uniprot.org/uniprot/I1S9G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the putative lipase ROG1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_09034 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJP4|||http://purl.uniprot.org/uniprot/Q4I174 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NBP35 and 2 CFD1 chains. http://togogenome.org/gene/229533:FGSG_07214 ^@ http://purl.uniprot.org/uniprot/I1RST1 ^@ Similarity ^@ Belongs to the CWC22 family. http://togogenome.org/gene/229533:FGSG_12846 ^@ http://purl.uniprot.org/uniprot/I1S7M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/229533:FGSG_05387 ^@ http://purl.uniprot.org/uniprot/I1RN26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLU family.|||Cytoplasm|||May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. http://togogenome.org/gene/229533:FGSG_04810 ^@ http://purl.uniprot.org/uniprot/I1RLK6 ^@ Similarity ^@ Belongs to the asaB hydroxylase/desaturase family. http://togogenome.org/gene/229533:FGSG_08672 ^@ http://purl.uniprot.org/uniprot/I1RWJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02421 ^@ http://purl.uniprot.org/uniprot/I1RFE7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/229533:FGSG_05488 ^@ http://purl.uniprot.org/uniprot/I1RNB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NCBP2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10305 ^@ http://purl.uniprot.org/uniprot/I1S0R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03373 ^@ http://purl.uniprot.org/uniprot/I1RHV8 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10500 ^@ http://purl.uniprot.org/uniprot/I1S1A0 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03370 ^@ http://purl.uniprot.org/uniprot/I1RHV5 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_05925 ^@ http://purl.uniprot.org/uniprot/I1RPF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10001 ^@ http://purl.uniprot.org/uniprot/I1RZZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/229533:FGSG_09494 ^@ http://purl.uniprot.org/uniprot/V6RPC7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_08578 ^@ http://purl.uniprot.org/uniprot/I1RWB5 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/229533:FGSG_12385 ^@ http://purl.uniprot.org/uniprot/I1S6B4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04592 ^@ http://purl.uniprot.org/uniprot/I1RL15 ^@ Biotechnology|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||Membrane|||Short chain dehydrogenase/reductase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_06512 ^@ http://purl.uniprot.org/uniprot/I1RR09 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/229533:FGSG_09989 ^@ http://purl.uniprot.org/uniprot/V6RXB3 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/229533:FGSG_11605 ^@ http://purl.uniprot.org/uniprot/I1S446 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01086 ^@ http://purl.uniprot.org/uniprot/I1RBY9 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/229533:FGSG_00589 ^@ http://purl.uniprot.org/uniprot/I1RAQ4 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/229533:FGSG_11079 ^@ http://purl.uniprot.org/uniprot/I1S2S6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01964 ^@ http://purl.uniprot.org/uniprot/I1RE84 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_05465 ^@ http://purl.uniprot.org/uniprot/I1RN99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.|||nucleolus http://togogenome.org/gene/229533:FGSG_09204 ^@ http://purl.uniprot.org/uniprot/I1RXX8 ^@ Similarity ^@ Belongs to the peptidase C14B family. http://togogenome.org/gene/229533:FGSG_03908 ^@ http://purl.uniprot.org/uniprot/V6R454 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_04265 ^@ http://purl.uniprot.org/uniprot/I1RK72 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/229533:FGSG_03667 ^@ http://purl.uniprot.org/uniprot/I1RIM7 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_13386 ^@ http://purl.uniprot.org/uniprot/I1S956 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09306 ^@ http://purl.uniprot.org/uniprot/I1RY69 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03369 ^@ http://purl.uniprot.org/uniprot/I1RHV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11594 ^@ http://purl.uniprot.org/uniprot/V6R223 ^@ Similarity ^@ Belongs to the TRL1 family. http://togogenome.org/gene/229533:FGSG_07666 ^@ http://purl.uniprot.org/uniprot/I1RTZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01410 ^@ http://purl.uniprot.org/uniprot/I1RCT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||actin patch http://togogenome.org/gene/229533:FGSG_06001 ^@ http://purl.uniprot.org/uniprot/I1RPM6 ^@ Cofactor|||Similarity ^@ Belongs to the 4HPPD family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/229533:FGSG_11398 ^@ http://purl.uniprot.org/uniprot/I1S3L0 ^@ Function|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Short-chain dehydrogenase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable). http://togogenome.org/gene/229533:FGSG_02696 ^@ http://purl.uniprot.org/uniprot/I1RG47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07832 ^@ http://purl.uniprot.org/uniprot/I1RUE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06386 ^@ http://purl.uniprot.org/uniprot/Q4I8S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OXR1 family.|||May be involved in protection from oxidative damage.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_00278 ^@ http://purl.uniprot.org/uniprot/I1R9W4 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Biotin synthase family. http://togogenome.org/gene/229533:FGSG_10193 ^@ http://purl.uniprot.org/uniprot/I1S0G6 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/229533:FGSG_04747 ^@ http://purl.uniprot.org/uniprot/I1RLF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01537 ^@ http://purl.uniprot.org/uniprot/I1RD48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MOZART1 family.|||Part of the gamma-tubulin complex.|||Required for gamma-tubulin complex recruitment to the microtubule organizing center (MTOC).|||spindle pole body http://togogenome.org/gene/229533:FGSG_00300 ^@ http://purl.uniprot.org/uniprot/I1R9Y4 ^@ Similarity ^@ Belongs to the ATPase delta chain family. http://togogenome.org/gene/229533:FGSG_00046 ^@ http://purl.uniprot.org/uniprot/I1R9B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ABC-type transporter; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). May be involved in the secretion of gramillins (Probable).|||Belongs to the ABC transporter superfamily. ABCC family.|||Cell membrane http://togogenome.org/gene/229533:FGSG_03033 ^@ http://purl.uniprot.org/uniprot/I1RGZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10029 ^@ http://purl.uniprot.org/uniprot/I1S017 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04968 ^@ http://purl.uniprot.org/uniprot/I1RLZ6 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_05578 ^@ http://purl.uniprot.org/uniprot/I1RNJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13011 ^@ http://purl.uniprot.org/uniprot/I1S835 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Homodimer.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/229533:FGSG_10140 ^@ http://purl.uniprot.org/uniprot/I1S0B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer. http://togogenome.org/gene/229533:FGSG_07794 ^@ http://purl.uniprot.org/uniprot/V6RI46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_10989 ^@ http://purl.uniprot.org/uniprot/I1S2J3 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.|||Short chain dehydrogenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable). http://togogenome.org/gene/229533:FGSG_02600 ^@ http://purl.uniprot.org/uniprot/I1RFV9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_07519 ^@ http://purl.uniprot.org/uniprot/I1RTL0 ^@ Similarity ^@ Belongs to the NUP family. http://togogenome.org/gene/229533:FGSG_06506 ^@ http://purl.uniprot.org/uniprot/I1RR04 ^@ Similarity ^@ Belongs to the polysaccharide monooxygenase AA13 family. http://togogenome.org/gene/229533:FGSG_11623 ^@ http://purl.uniprot.org/uniprot/I1S462 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00587 ^@ http://purl.uniprot.org/uniprot/A0A1I9EVV7|||http://purl.uniprot.org/uniprot/Q4IQC1 ^@ Function|||Similarity ^@ Belongs to the AB hydrolase superfamily.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity).|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit. http://togogenome.org/gene/229533:FGSG_02441 ^@ http://purl.uniprot.org/uniprot/I1RFG7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/229533:FGSG_06646 ^@ http://purl.uniprot.org/uniprot/I1RRC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/229533:FGSG_12889 ^@ http://purl.uniprot.org/uniprot/I1S7R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM41 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_00634 ^@ http://purl.uniprot.org/uniprot/I1RAU7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/229533:FGSG_10816 ^@ http://purl.uniprot.org/uniprot/V6RVB4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02697 ^@ http://purl.uniprot.org/uniprot/I1RG48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08738 ^@ http://purl.uniprot.org/uniprot/I1RWQ8 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/229533:FGSG_09019 ^@ http://purl.uniprot.org/uniprot/I1RXF3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06269 ^@ http://purl.uniprot.org/uniprot/I1RQC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05119 ^@ http://purl.uniprot.org/uniprot/I1RMD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04980 ^@ http://purl.uniprot.org/uniprot/I1RM07 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/229533:FGSG_05556 ^@ http://purl.uniprot.org/uniprot/I1RNH6 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/229533:FGSG_06699 ^@ http://purl.uniprot.org/uniprot/I1RRH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04804 ^@ http://purl.uniprot.org/uniprot/I1RLK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05958 ^@ http://purl.uniprot.org/uniprot/I1RPI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06627 ^@ http://purl.uniprot.org/uniprot/I1RRB0 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/229533:FGSG_08610 ^@ http://purl.uniprot.org/uniprot/I1RWE4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/229533:FGSG_13385 ^@ http://purl.uniprot.org/uniprot/I1S955 ^@ Similarity ^@ Belongs to the shaker potassium channel beta subunit family. http://togogenome.org/gene/229533:FGSG_00949 ^@ http://purl.uniprot.org/uniprot/I1RBM1 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/229533:FGSG_00565 ^@ http://purl.uniprot.org/uniprot/I1RAN3 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/229533:FGSG_10899 ^@ http://purl.uniprot.org/uniprot/I1S2B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KXD1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.|||Endosome http://togogenome.org/gene/229533:FGSG_07631 ^@ http://purl.uniprot.org/uniprot/I1RTW3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_11069 ^@ http://purl.uniprot.org/uniprot/I1S2R7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06356 ^@ http://purl.uniprot.org/uniprot/I1RQL1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00359 ^@ http://purl.uniprot.org/uniprot/V6QV09 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/229533:FGSG_09784 ^@ http://purl.uniprot.org/uniprot/I1RZE5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/229533:FGSG_03463 ^@ http://purl.uniprot.org/uniprot/I1RI40 ^@ Similarity ^@ Belongs to the tpcK family. http://togogenome.org/gene/229533:FGSG_00489 ^@ http://purl.uniprot.org/uniprot/I1RAG2 ^@ Similarity ^@ Belongs to the PheA/TfdB FAD monooxygenase family.|||Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_09515 ^@ http://purl.uniprot.org/uniprot/I1RYQ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_09021 ^@ http://purl.uniprot.org/uniprot/I1RXF5 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/229533:FGSG_03553 ^@ http://purl.uniprot.org/uniprot/I1RIC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/229533:FGSG_09646 ^@ http://purl.uniprot.org/uniprot/I1RZ28 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_08702 ^@ http://purl.uniprot.org/uniprot/I1RWM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_04593 ^@ http://purl.uniprot.org/uniprot/I1RL16 ^@ Biotechnology|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||Membrane|||Polyprenyl transferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_03396 ^@ http://purl.uniprot.org/uniprot/I1RHY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10982 ^@ http://purl.uniprot.org/uniprot/I1S2I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S9B family.|||Membrane|||Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_04468 ^@ http://purl.uniprot.org/uniprot/I1RKQ3 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_02237 ^@ http://purl.uniprot.org/uniprot/I1REX8 ^@ Similarity ^@ Belongs to the WD repeat MET30/SCONB/SCON-2 family. http://togogenome.org/gene/229533:FGSG_12767 ^@ http://purl.uniprot.org/uniprot/I1S7E4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06757 ^@ http://purl.uniprot.org/uniprot/I1RRM5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/229533:FGSG_10738 ^@ http://purl.uniprot.org/uniprot/I1S1W4 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the peptidase M67A family. http://togogenome.org/gene/229533:FGSG_09354 ^@ http://purl.uniprot.org/uniprot/I1RYB2 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_07169 ^@ http://purl.uniprot.org/uniprot/I1RSP1 ^@ Similarity ^@ Belongs to the XPO2/CSE1 family. http://togogenome.org/gene/229533:FGSG_08377 ^@ http://purl.uniprot.org/uniprot/I1RVT4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_02637 ^@ http://purl.uniprot.org/uniprot/A0A1I9F2S9|||http://purl.uniprot.org/uniprot/Q4IJH1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_05720 ^@ http://purl.uniprot.org/uniprot/I1RNX5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_10506 ^@ http://purl.uniprot.org/uniprot/I1S1A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09244 ^@ http://purl.uniprot.org/uniprot/I1RY15 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/229533:FGSG_11955 ^@ http://purl.uniprot.org/uniprot/A0A1I9EYT1|||http://purl.uniprot.org/uniprot/I1S537 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the velvet family. VeA subfamily.|||Component of the heterotrimeric velvet complex composed of laeA, ve1 and velB; Ve1 acting as a bridging protein between laeA and velB (By similarity). Interacts directly with laeA and velB (PubMed:23874628).|||Component of the velvet transcription factor complex that controls sexual/asexual developmental ratio in response to light, promoting sexual development in the darkness while stimulating asexual sporulation under illumination (By similarity). The velvet complex hat acts as a global regulator for secondary metabolite gene expression (PubMed:22140571). Controls the expression of the aurofusarin and trichothecene gene clusters (PubMed:22013911). Controls also the expression of the deoxynivalenol (DON) gene cluster (PubMed:22140571). Regulates hyphal growth and pigment formation (PubMed:22140571). Acts as a positive regulator of virulence (PubMed:22013911, PubMed:22140571).|||Cytoplasm|||Impairs aurofusarin and trichothecene biosynthesis (PubMed:22013911). Reduces deoxynivalenol (DON) biosynthesis (PubMed:22140571). Results in highly reduced sporulation (PubMed:22013911). Reduces the hydrophobicity of the cell surface (PubMed:22140571, PubMed:22013911). Shows increased resistance to osmotic stress and cell wall-damaging agents, but increased sensitivity to iprodione and fludioxonil fungicides (PubMed:22140571, PubMed:22713714).|||Nucleus|||The C-terminal PEST domain is a region rich in proline, glutamic acid, serine and threonine residues that is required for the light-dependent regulation of development and secondary metabolism (By similarity). http://togogenome.org/gene/229533:FGSG_01264 ^@ http://purl.uniprot.org/uniprot/I1RCF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RTC4 family.|||May be involved in a process influencing telomere capping.|||Nucleus http://togogenome.org/gene/229533:FGSG_06836 ^@ http://purl.uniprot.org/uniprot/I1RRU6 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_01052 ^@ http://purl.uniprot.org/uniprot/I1RBW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/229533:FGSG_00108 ^@ http://purl.uniprot.org/uniprot/I1R9G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03154 ^@ http://purl.uniprot.org/uniprot/I1RHA8 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_09810 ^@ http://purl.uniprot.org/uniprot/I1RZG9 ^@ Similarity ^@ Belongs to the HIT family. http://togogenome.org/gene/229533:FGSG_03209 ^@ http://purl.uniprot.org/uniprot/I1RHF8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_02976 ^@ http://purl.uniprot.org/uniprot/I1RGU8 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_05375 ^@ http://purl.uniprot.org/uniprot/V6R9L8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_11684 ^@ http://purl.uniprot.org/uniprot/I1S4B7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00082 ^@ http://purl.uniprot.org/uniprot/I1R9E6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_05295 ^@ http://purl.uniprot.org/uniprot/I1RMU5 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_01278 ^@ http://purl.uniprot.org/uniprot/I1RCG4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/229533:FGSG_07138 ^@ http://purl.uniprot.org/uniprot/I1RSL5 ^@ Similarity ^@ Belongs to the UreD family. http://togogenome.org/gene/229533:FGSG_05090 ^@ http://purl.uniprot.org/uniprot/A0A1I9FSD9|||http://purl.uniprot.org/uniprot/Q4ICG8 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/229533:FGSG_09464 ^@ http://purl.uniprot.org/uniprot/I1RYK8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12798 ^@ http://purl.uniprot.org/uniprot/I1S7H5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10595 ^@ http://purl.uniprot.org/uniprot/I1S1J0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_00040 ^@ http://purl.uniprot.org/uniprot/I1R9A9 ^@ Function|||Similarity ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Methyltransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_04104 ^@ http://purl.uniprot.org/uniprot/I1RJS2 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/229533:FGSG_03605 ^@ http://purl.uniprot.org/uniprot/I1RIH2 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_12900 ^@ http://purl.uniprot.org/uniprot/I1S7S5 ^@ Similarity ^@ Belongs to the TRAPPC13 family. http://togogenome.org/gene/229533:FGSG_10403 ^@ http://purl.uniprot.org/uniprot/I1S110 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/229533:FGSG_04879 ^@ http://purl.uniprot.org/uniprot/I1RLR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11055 ^@ http://purl.uniprot.org/uniprot/I1S2Q5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/229533:FGSG_00694 ^@ http://purl.uniprot.org/uniprot/I1RAZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04326 ^@ http://purl.uniprot.org/uniprot/I1RKC6 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/229533:FGSG_02395 ^@ http://purl.uniprot.org/uniprot/A0A098D6U0 ^@ Disruption Phenotype|||Domain|||Function|||Induction ^@ Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).|||Multidomain protein; including a starter unit:ACP transacylase (SAT) that selects the starter unit; a ketosynthase (KS) that catalyzes repeated decarboxylative condensation to elongate the polyketide backbone; a malonyl-CoA:ACP transacylase (MAT) that selects and transfers the extender unit malonyl-CoA; a product template (PT) domain that controls the immediate cyclization regioselectivity of the reactive polyketide backbone; and an acyl-carrier protein (ACP) that serves as the tether of the growing and completed polyketide via its phosphopantetheinyl arm (By similarity).|||Non-reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEA1 exhibits broad starter-unit specificities toward fatty acyl-CoAs ranging in sizes between C6 and C16 and displays the highest activity toward decanoyl-CoA (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).|||Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793, PubMed:16517624).|||The release of the polyketide chain from the non-reducing polyketide synthase is mediated by the thioesterase (TE) domain localized at the C-ter of the protein (By similarity). http://togogenome.org/gene/229533:FGSG_01618 ^@ http://purl.uniprot.org/uniprot/I1RDC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/229533:FGSG_00774 ^@ http://purl.uniprot.org/uniprot/I1RB67 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05218 ^@ http://purl.uniprot.org/uniprot/I1RMM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/229533:FGSG_00834 ^@ http://purl.uniprot.org/uniprot/I1RBC1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/229533:FGSG_01157 ^@ http://purl.uniprot.org/uniprot/I1RC54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Required both for recombination and for the repair of DNA damage caused by X-rays. http://togogenome.org/gene/229533:FGSG_09773 ^@ http://purl.uniprot.org/uniprot/A0A1I9FNI4|||http://purl.uniprot.org/uniprot/Q4HZ35 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_07671 ^@ http://purl.uniprot.org/uniprot/I1RU01 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_03729 ^@ http://purl.uniprot.org/uniprot/I1RIT5 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_07347 ^@ http://purl.uniprot.org/uniprot/I1RT50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/229533:FGSG_01519 ^@ http://purl.uniprot.org/uniprot/Q4IMN9 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/229533:FGSG_02640 ^@ http://purl.uniprot.org/uniprot/I1RFZ3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/229533:FGSG_08415 ^@ http://purl.uniprot.org/uniprot/I1RVW8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/229533:FGSG_00838 ^@ http://purl.uniprot.org/uniprot/I1RBC4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/229533:FGSG_00421 ^@ http://purl.uniprot.org/uniprot/I1RA94 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/229533:FGSG_05557 ^@ http://purl.uniprot.org/uniprot/I1RNH7 ^@ Similarity ^@ Belongs to the COG1 family. http://togogenome.org/gene/229533:FGSG_04913 ^@ http://purl.uniprot.org/uniprot/I1RLU4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_07058 ^@ http://purl.uniprot.org/uniprot/I1RSE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_04125 ^@ http://purl.uniprot.org/uniprot/I1RJU3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/229533:FGSG_07225 ^@ http://purl.uniprot.org/uniprot/I1RSU1 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/229533:FGSG_05751 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQL5|||http://purl.uniprot.org/uniprot/Q4IAK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.|||Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.|||Component of the SWR1 chromatin-remodeling complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_12534 ^@ http://purl.uniprot.org/uniprot/I1S6R1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09614 ^@ http://purl.uniprot.org/uniprot/I1RYZ7 ^@ Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/229533:FGSG_04578 ^@ http://purl.uniprot.org/uniprot/I1RL04 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/229533:FGSG_00926 ^@ http://purl.uniprot.org/uniprot/I1RBK1 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/229533:FGSG_10999 ^@ http://purl.uniprot.org/uniprot/A0A1I9FXT9|||http://purl.uniprot.org/uniprot/I1S2K3 ^@ Activity Regulation|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 11 (cellulase G) family.|||Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.|||Expression is highly induced by xylan.|||Inhibited by the proteinaceous endoxylanase inhibitor I from T.aestivum (TAXI-I).|||Secreted http://togogenome.org/gene/229533:FGSG_07959 ^@ http://purl.uniprot.org/uniprot/I1RUQ7 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/229533:FGSG_01289 ^@ http://purl.uniprot.org/uniprot/I1RCH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/229533:FGSG_03284 ^@ http://purl.uniprot.org/uniprot/I1RHM4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||telomere http://togogenome.org/gene/229533:FGSG_05733 ^@ http://purl.uniprot.org/uniprot/I1RNY6 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/229533:FGSG_06260 ^@ http://purl.uniprot.org/uniprot/Q4I948 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).|||Nucleus http://togogenome.org/gene/229533:FGSG_05777 ^@ http://purl.uniprot.org/uniprot/I1RP27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/229533:FGSG_11062 ^@ http://purl.uniprot.org/uniprot/I1S2R2 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_12443 ^@ http://purl.uniprot.org/uniprot/I1S6H2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_08427 ^@ http://purl.uniprot.org/uniprot/I1RVY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05364 ^@ http://purl.uniprot.org/uniprot/I1RN07 ^@ Function|||Similarity ^@ Belongs to the BYE1 family.|||Negative regulator of transcription elongation. http://togogenome.org/gene/229533:FGSG_10198 ^@ http://purl.uniprot.org/uniprot/I1S0H0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06554 ^@ http://purl.uniprot.org/uniprot/I1RR45 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide.|||Serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/229533:FGSG_04598 ^@ http://purl.uniprot.org/uniprot/I1RL20 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_05323 ^@ http://purl.uniprot.org/uniprot/I1RMX0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/229533:FGSG_03664 ^@ http://purl.uniprot.org/uniprot/I1RIM5 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/229533:FGSG_03507 ^@ http://purl.uniprot.org/uniprot/I1RI80 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_12183 ^@ http://purl.uniprot.org/uniprot/I1S5R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane|||Required for vacuolar protein sorting. http://togogenome.org/gene/229533:FGSG_08864 ^@ http://purl.uniprot.org/uniprot/I1RX21 ^@ Function ^@ Required for the assembly of cytochrome c oxidase. http://togogenome.org/gene/229533:FGSG_07285 ^@ http://purl.uniprot.org/uniprot/I1RSZ7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/229533:FGSG_13878 ^@ http://purl.uniprot.org/uniprot/I1SAJ7 ^@ Disruption Phenotype|||Domain|||Function|||Induction|||Similarity ^@ Belongs to the NRP synthetase family.|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. NRPS5 has the following 7 module architecture: A-C-A-T-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-E-C-A-T-TE.|||Nonribosomal peptide synthetase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).|||Produces significantly smaller lesions on susceptible wheat cultivars. http://togogenome.org/gene/229533:FGSG_03861 ^@ http://purl.uniprot.org/uniprot/I1RJ58 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09519 ^@ http://purl.uniprot.org/uniprot/I1RYR1 ^@ Function|||Subcellular Location Annotation ^@ Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus http://togogenome.org/gene/229533:FGSG_09374 ^@ http://purl.uniprot.org/uniprot/I1RYC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06705 ^@ http://purl.uniprot.org/uniprot/I1RRI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/229533:FGSG_00654 ^@ http://purl.uniprot.org/uniprot/V6QUG0 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/229533:FGSG_08390 ^@ http://purl.uniprot.org/uniprot/I1RVU5 ^@ Activity Regulation|||Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Cytoplasm|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/229533:FGSG_08347 ^@ http://purl.uniprot.org/uniprot/I1RVQ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13398 ^@ http://purl.uniprot.org/uniprot/I1S968 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/229533:FGSG_02649 ^@ http://purl.uniprot.org/uniprot/I1RG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||cis-Golgi network http://togogenome.org/gene/229533:FGSG_03181 ^@ http://purl.uniprot.org/uniprot/I1RHD4 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_10003 ^@ http://purl.uniprot.org/uniprot/I1RZZ3 ^@ Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Abolishes the production of ergosterol and leads to the accumulation of sterol intermediates (PubMed:22947191). Leads to reduced deoxynivalenol (DON) production (PubMed:22947191). Results in reduced mycelial growth as well as less conidia (PubMed:22947191). Leads to decreased virulence (PubMed:22947191). Exhibits a significantly increased sensitivity to the divalent cations Cu(2+), Mg(2+) and Ca(2+), as well as to the trivalent cations Fe(3+) and Al(3+) (PubMed:22947191). Shows increased resistance to cell wall-degrading enzymes and significantly increases sensitivity to osmotic stress mediated by NaCl and D-sorbitol, and to oxidative stress generated by H(2)O(2) and paraquat (PubMed:22947191). Decreases tolerance to sterol biosynthesis inhibitors, including triadimefon and tebuconazole (targeting sterol 14-alpha-demethylase), the amine fungicides tridemorph, fenpropidin and spiroxamine (targeting sterol C-14 reductase or sterol delta-7,8-isomerase) and the polyene fungicides nystatin and amphotericin B (binding to ergosterol) (PubMed:22947191). Does not affect the sensitivity to the dicarboximide fungicide iprodione (PubMed:22947191). Finally, ERG4 deletion leads to increased expression of the ergosterol biosynthesis genes CYP51A, CYP51B, CYP51C, ERG2, ERG6A, ERG6B, ERG7, ERG24A and ERG24B (PubMed:22947191).|||Belongs to the ERG4/ERG24 family.|||Delta(24(24(1)))-sterol reductase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:22947191). ERG4 catalyzes the last step of ergosterol biosynthesis by converting ergosta-5,7,22,24(28)-tetraen-3beta-ol into ergosterol (PubMed:22947191). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol. http://togogenome.org/gene/229533:FGSG_11092 ^@ http://purl.uniprot.org/uniprot/I1S2T9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09592 ^@ http://purl.uniprot.org/uniprot/I1RYX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00722 ^@ http://purl.uniprot.org/uniprot/V6QVH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_08182 ^@ http://purl.uniprot.org/uniprot/I1RVB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04062 ^@ http://purl.uniprot.org/uniprot/I1RJN5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_05612 ^@ http://purl.uniprot.org/uniprot/I1RNM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00506 ^@ http://purl.uniprot.org/uniprot/I1RAH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/229533:FGSG_01015 ^@ http://purl.uniprot.org/uniprot/I1RBS5 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/229533:FGSG_00136 ^@ http://purl.uniprot.org/uniprot/I1R9J4 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_00395 ^@ http://purl.uniprot.org/uniprot/I1RA70 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/229533:FGSG_10078 ^@ http://purl.uniprot.org/uniprot/I1S062 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic12 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04774 ^@ http://purl.uniprot.org/uniprot/I1RLH4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01345 ^@ http://purl.uniprot.org/uniprot/A0A1I9EYG5|||http://purl.uniprot.org/uniprot/Q4IN63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNO1 family.|||Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).|||Cytoplasm|||Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).|||Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.|||nucleolus http://togogenome.org/gene/229533:FGSG_02165 ^@ http://purl.uniprot.org/uniprot/V6QYX9 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_10693 ^@ http://purl.uniprot.org/uniprot/I1S1S7 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/229533:FGSG_11522 ^@ http://purl.uniprot.org/uniprot/I1S3X2 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10790 ^@ http://purl.uniprot.org/uniprot/I1S210 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07210 ^@ http://purl.uniprot.org/uniprot/I1RSS7 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/229533:FGSG_06328 ^@ http://purl.uniprot.org/uniprot/I1RQI4 ^@ Similarity ^@ Belongs to the XFP family. http://togogenome.org/gene/229533:FGSG_08811 ^@ http://purl.uniprot.org/uniprot/I1RWX5 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/229533:FGSG_04480 ^@ http://purl.uniprot.org/uniprot/I1RKR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00297 ^@ http://purl.uniprot.org/uniprot/I1R9Y1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/229533:FGSG_04654 ^@ http://purl.uniprot.org/uniprot/I1RL71 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_02793 ^@ http://purl.uniprot.org/uniprot/I1RGD4 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG23 family.|||Cytoplasm|||Forms a complex with ATG9 and ATG27 (By similarity).|||Preautophagosomal structure membrane|||Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy (By similarity). Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). http://togogenome.org/gene/229533:FGSG_13224 ^@ http://purl.uniprot.org/uniprot/I1S8P6 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_11157 ^@ http://purl.uniprot.org/uniprot/I1S2Z7 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_00625 ^@ http://purl.uniprot.org/uniprot/I1RAT9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01283 ^@ http://purl.uniprot.org/uniprot/I1RCG9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/229533:FGSG_03779 ^@ http://purl.uniprot.org/uniprot/I1RIY2 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/229533:FGSG_06544 ^@ http://purl.uniprot.org/uniprot/V6RDH3 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/229533:FGSG_08133 ^@ http://purl.uniprot.org/uniprot/I1RV69 ^@ Function|||Similarity|||Subunit ^@ Associates with DNA double-strand breaks.|||Belongs to the PI3/PI4-kinase family.|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability. http://togogenome.org/gene/229533:FGSG_07374 ^@ http://purl.uniprot.org/uniprot/I1RT75 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family. QTRT2 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Heterodimer of a catalytic subunit and an accessory subunit.|||Non-catalytic subunit of the queuine tRNA-ribosyltransferase (TGT) that catalyzes the base-exchange of a guanine (G) residue with queuine (Q) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine). http://togogenome.org/gene/229533:FGSG_04819 ^@ http://purl.uniprot.org/uniprot/I1RLL4 ^@ Similarity ^@ Belongs to the Cyclase 1 superfamily. http://togogenome.org/gene/229533:FGSG_09820 ^@ http://purl.uniprot.org/uniprot/I1RZH8 ^@ Cofactor|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/229533:FGSG_08372 ^@ http://purl.uniprot.org/uniprot/I1RVS9 ^@ Similarity ^@ Belongs to the XPC family. http://togogenome.org/gene/229533:FGSG_00577 ^@ http://purl.uniprot.org/uniprot/I1RAP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03927 ^@ http://purl.uniprot.org/uniprot/I1RJB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/229533:FGSG_08496 ^@ http://purl.uniprot.org/uniprot/I1RW42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09074 ^@ http://purl.uniprot.org/uniprot/I1RXK3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_06073 ^@ http://purl.uniprot.org/uniprot/I1RPU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_08747 ^@ http://purl.uniprot.org/uniprot/I1RWR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_05230 ^@ http://purl.uniprot.org/uniprot/I1RMN7 ^@ Similarity ^@ Belongs to the HGH1 family. http://togogenome.org/gene/229533:FGSG_11472 ^@ http://purl.uniprot.org/uniprot/I1S3S6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_05524 ^@ http://purl.uniprot.org/uniprot/I1RNE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09439 ^@ http://purl.uniprot.org/uniprot/I1RYI6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06390 ^@ http://purl.uniprot.org/uniprot/I1RQP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02678 ^@ http://purl.uniprot.org/uniprot/I1RG29 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/229533:FGSG_03529 ^@ http://purl.uniprot.org/uniprot/V6R5G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/229533:FGSG_01955 ^@ http://purl.uniprot.org/uniprot/I1RE76 ^@ PTM|||Similarity ^@ Belongs to the eIF-5A family.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/229533:FGSG_04901 ^@ http://purl.uniprot.org/uniprot/I1RLT2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01751 ^@ http://purl.uniprot.org/uniprot/I1RDP0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||telomere http://togogenome.org/gene/229533:FGSG_03745 ^@ http://purl.uniprot.org/uniprot/I1RIV0 ^@ Similarity ^@ Belongs to the lysine N-acyltransferase MbtK family. http://togogenome.org/gene/229533:FGSG_12597 ^@ http://purl.uniprot.org/uniprot/I1S6X4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04143 ^@ http://purl.uniprot.org/uniprot/I1RJW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Secreted http://togogenome.org/gene/229533:FGSG_11292 ^@ http://purl.uniprot.org/uniprot/I1S3B6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10483 ^@ http://purl.uniprot.org/uniprot/I1S184 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06268 ^@ http://purl.uniprot.org/uniprot/I1RQC7 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family. http://togogenome.org/gene/229533:FGSG_08445 ^@ http://purl.uniprot.org/uniprot/I1RVZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus|||Responsible for methylating the 5'-cap structure of mRNAs. http://togogenome.org/gene/229533:FGSG_02681 ^@ http://purl.uniprot.org/uniprot/I1RG32 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/229533:FGSG_10397 ^@ http://purl.uniprot.org/uniprot/I1S104 ^@ Biotechnology|||Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the trichodiene synthase family.|||Expressed under trichothecene-inducing conditions.|||Leads to complete loss of culmorin production (PubMed:19880637). Does not affect the trichothecene biosynthetic pathway since 15-acetyldeoxynivalenol (15ADON) is still produced (PubMed:19880637). Keeps the ability to convert exogenously added longiborneol to culmorin (PubMed:19880637).|||Longiborneol synthase CLM1 is a potential target to reduce Fusarium head blight disease. 3D-structure modeling based on known 3D-structure of losely related enzymes has been used for screening of hypothetical inhibitors of CLM1 catalytic activity.|||Terpene cyclase involved in the biosynthesis of culmorin, a tricyclic sesquiterpene diol reported to have antifungal activity and some phytotoxicity to wheat coleoptile tissue, contributing to Fusarium head blight disease (PubMed:19880637) (Probable). The terpene cyclase CLM1 is responsible for the cyclization of farnesyl diphosphate into the intermediate longiborneol (PubMed:19880637). Longiborneol is then hydroxylated in a regio- and endo-stereoselective manner at position C-11 by the cytochrome P450 monooxygenase CLM2 to produce culmorin (PubMed:26673640). Additional non-specific oxygenases are also able to hydroxylate longiborneol at other sites than C-11 leading to 3-hydroxylongiborneol, 5-hydroxylongiborneol, 12-hydroxylongiborneol and 15-hydroxylongiborneol (PubMed:26673640). Moreover, another oxygenase capable of installing a C-11 exo-hydroxy group in longiborneol can also yield 11-epi-acetylculmorin (PubMed:26673640). The production of these longiborneol derivatives is dwarfed by the high abundance of culmorin, suggesting that CLM2 displays superior enzymatic activity to the unidentified, possibly promiscuous, additional oxygenases (PubMed:26673640). http://togogenome.org/gene/229533:FGSG_03918 ^@ http://purl.uniprot.org/uniprot/I1RJA9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_09818 ^@ http://purl.uniprot.org/uniprot/I1RZH6 ^@ Similarity ^@ Belongs to the TYW1 family. http://togogenome.org/gene/229533:FGSG_11884 ^@ http://purl.uniprot.org/uniprot/I1S4W6 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03285 ^@ http://purl.uniprot.org/uniprot/I1RHM5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_12250 ^@ http://purl.uniprot.org/uniprot/I1S5X9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB7 subunit family.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/229533:FGSG_05111 ^@ http://purl.uniprot.org/uniprot/I1RMC2 ^@ Function|||Similarity ^@ Belongs to the HTP reductase family.|||Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate. http://togogenome.org/gene/229533:FGSG_10144 ^@ http://purl.uniprot.org/uniprot/I1S0C2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with TAH18. Interacts with MIA40.|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/229533:FGSG_04120 ^@ http://purl.uniprot.org/uniprot/I1RJT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/229533:FGSG_00574 ^@ http://purl.uniprot.org/uniprot/I1RAP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13131 ^@ http://purl.uniprot.org/uniprot/Q4I613 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs. In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs (By similarity). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity).|||Divalent metal cation.|||Nucleus http://togogenome.org/gene/229533:FGSG_11057 ^@ http://purl.uniprot.org/uniprot/I1S2Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09683 ^@ http://purl.uniprot.org/uniprot/I1RZ57 ^@ Similarity|||Subunit ^@ Belongs to the EXO5 family.|||Monomer. http://togogenome.org/gene/229533:FGSG_02397 ^@ http://purl.uniprot.org/uniprot/A0A0E0RTV6 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).|||FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).|||Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793). http://togogenome.org/gene/229533:FGSG_08566 ^@ http://purl.uniprot.org/uniprot/I1RWA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA2 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06392 ^@ http://purl.uniprot.org/uniprot/I1RQP5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.|||Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. http://togogenome.org/gene/229533:FGSG_09524 ^@ http://purl.uniprot.org/uniprot/I1RYR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04669 ^@ http://purl.uniprot.org/uniprot/I1RL84 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiD family. UbiD-like/FDC subfamily.|||Binds 1 prenylated FMN (prenyl-FMN) per subunit.|||Catalyzes the reversible decarboxylation of aromatic carboxylic acids like ferulic acid, p-coumaric acid or cinnamic acid, producing the corresponding vinyl derivatives 4-vinylphenol, 4-vinylguaiacol, and styrene, respectively, which play the role of aroma metabolites.|||Cytoplasm|||Homodimer. May form higher order oligomers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_05194 ^@ http://purl.uniprot.org/uniprot/V6R9P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/229533:FGSG_01870 ^@ http://purl.uniprot.org/uniprot/I1RE00 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/229533:FGSG_13258 ^@ http://purl.uniprot.org/uniprot/I1S8T0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'. http://togogenome.org/gene/229533:FGSG_13983 ^@ http://purl.uniprot.org/uniprot/I1SAV2 ^@ Similarity ^@ Belongs to the PheA/TfdB FAD monooxygenase family.|||Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_00168 ^@ http://purl.uniprot.org/uniprot/I1R9M0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/229533:FGSG_10823 ^@ http://purl.uniprot.org/uniprot/I1S239 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12937 ^@ http://purl.uniprot.org/uniprot/I1S7W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_05076 ^@ http://purl.uniprot.org/uniprot/I1RM91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09434 ^@ http://purl.uniprot.org/uniprot/I1RYI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex SPC19 family.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_09583 ^@ http://purl.uniprot.org/uniprot/I1RYX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01863 ^@ http://purl.uniprot.org/uniprot/I1RDZ4 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/229533:FGSG_05239 ^@ http://purl.uniprot.org/uniprot/I1RMP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01021 ^@ http://purl.uniprot.org/uniprot/I1RBT1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/229533:FGSG_12602 ^@ http://purl.uniprot.org/uniprot/I1S6X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09040 ^@ http://purl.uniprot.org/uniprot/I1RXH1 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/229533:FGSG_05653 ^@ http://purl.uniprot.org/uniprot/I1RNR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01151 ^@ http://purl.uniprot.org/uniprot/I1RC48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/229533:FGSG_07174 ^@ http://purl.uniprot.org/uniprot/I1RSP6 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/229533:FGSG_00226 ^@ http://purl.uniprot.org/uniprot/I1R9S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13112 ^@ http://purl.uniprot.org/uniprot/Q4I665 ^@ Function|||Similarity ^@ Belongs to the PpiC/parvulin rotamase family. PIN4 subfamily.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/229533:FGSG_10685 ^@ http://purl.uniprot.org/uniprot/I1S1R9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_01511 ^@ http://purl.uniprot.org/uniprot/I1RD24 ^@ Similarity ^@ Belongs to the synembryn family. http://togogenome.org/gene/229533:FGSG_10480 ^@ http://purl.uniprot.org/uniprot/I1S181 ^@ Similarity ^@ Belongs to the OBAP family. http://togogenome.org/gene/229533:FGSG_08911 ^@ http://purl.uniprot.org/uniprot/I1RX61 ^@ Similarity ^@ Belongs to the chloroperoxidase family. http://togogenome.org/gene/229533:FGSG_03638 ^@ http://purl.uniprot.org/uniprot/I1RIK1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_02379 ^@ http://purl.uniprot.org/uniprot/I1RFB0 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02741 ^@ http://purl.uniprot.org/uniprot/I1RG85 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06061 ^@ http://purl.uniprot.org/uniprot/I1RPT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_09913 ^@ http://purl.uniprot.org/uniprot/V6RRC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03633 ^@ http://purl.uniprot.org/uniprot/I1RIJ6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/229533:FGSG_02064 ^@ http://purl.uniprot.org/uniprot/I1REH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03379 ^@ http://purl.uniprot.org/uniprot/I1RHW3 ^@ Similarity ^@ Belongs to the RNase T2 family. http://togogenome.org/gene/229533:FGSG_03427 ^@ http://purl.uniprot.org/uniprot/I1RI08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_05644 ^@ http://purl.uniprot.org/uniprot/I1RNQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/229533:FGSG_00052 ^@ http://purl.uniprot.org/uniprot/I1R9B9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05931 ^@ http://purl.uniprot.org/uniprot/I1RPG2 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/229533:FGSG_03546 ^@ http://purl.uniprot.org/uniprot/I1RIB5 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03139 ^@ http://purl.uniprot.org/uniprot/I1RH94 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_08452 ^@ http://purl.uniprot.org/uniprot/I1RW00 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/229533:FGSG_00556 ^@ http://purl.uniprot.org/uniprot/I1RAM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space|||Required for the assembly of cytochrome c oxidase. http://togogenome.org/gene/229533:FGSG_07105 ^@ http://purl.uniprot.org/uniprot/I1RSI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00979 ^@ http://purl.uniprot.org/uniprot/V6R2Z2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09254 ^@ http://purl.uniprot.org/uniprot/I1RY25 ^@ Similarity ^@ Belongs to the patched family. http://togogenome.org/gene/229533:FGSG_01857 ^@ http://purl.uniprot.org/uniprot/I1RDY8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02030 ^@ http://purl.uniprot.org/uniprot/I1REE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/229533:FGSG_10967 ^@ http://purl.uniprot.org/uniprot/I1S2H3 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/229533:FGSG_08931 ^@ http://purl.uniprot.org/uniprot/I1RX80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04304 ^@ http://purl.uniprot.org/uniprot/I1RKA7 ^@ Function|||Similarity ^@ Belongs to the WD repeat CIA1 family.|||Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. http://togogenome.org/gene/229533:FGSG_04817 ^@ http://purl.uniprot.org/uniprot/I1RLL2 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/229533:FGSG_02756 ^@ http://purl.uniprot.org/uniprot/I1RG99 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/229533:FGSG_08609 ^@ http://purl.uniprot.org/uniprot/I1RWE3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_13136 ^@ http://purl.uniprot.org/uniprot/I1S8F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03744 ^@ http://purl.uniprot.org/uniprot/I1RIU9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05999 ^@ http://purl.uniprot.org/uniprot/I1RPM4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/229533:FGSG_00798 ^@ http://purl.uniprot.org/uniprot/V6QUW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability. http://togogenome.org/gene/229533:FGSG_02990 ^@ http://purl.uniprot.org/uniprot/I1RGW0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10194 ^@ http://purl.uniprot.org/uniprot/I1S0G7 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_11364 ^@ http://purl.uniprot.org/uniprot/I1S3I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11632 ^@ http://purl.uniprot.org/uniprot/I1S467 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/229533:FGSG_12188 ^@ http://purl.uniprot.org/uniprot/I1S5R7 ^@ Function ^@ Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity. http://togogenome.org/gene/229533:FGSG_02968 ^@ http://purl.uniprot.org/uniprot/I1RGU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01372 ^@ http://purl.uniprot.org/uniprot/I1RCP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLA1 family.|||Cell membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04948 ^@ http://purl.uniprot.org/uniprot/I1RLX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/229533:FGSG_07302 ^@ http://purl.uniprot.org/uniprot/I1RT12 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/229533:FGSG_02170 ^@ http://purl.uniprot.org/uniprot/I1RES0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family.|||Secreted http://togogenome.org/gene/229533:FGSG_05531 ^@ http://purl.uniprot.org/uniprot/I1RNF5 ^@ Similarity ^@ Belongs to the KTI12 family. http://togogenome.org/gene/229533:FGSG_05640 ^@ http://purl.uniprot.org/uniprot/I1RNQ5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/229533:FGSG_08078 ^@ http://purl.uniprot.org/uniprot/I1RV18 ^@ Function|||Induction|||Similarity ^@ Amidase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).|||Belongs to the amidase family.|||Highly expressed under trichothecene-producing conditions. http://togogenome.org/gene/229533:FGSG_07335 ^@ http://purl.uniprot.org/uniprot/I1RT41 ^@ Function|||Similarity ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family. http://togogenome.org/gene/229533:FGSG_09421 ^@ http://purl.uniprot.org/uniprot/I1RYH0 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_03408 ^@ http://purl.uniprot.org/uniprot/I1RHY9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05598 ^@ http://purl.uniprot.org/uniprot/I1RNL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06312 ^@ http://purl.uniprot.org/uniprot/I1RQH0 ^@ Function|||Similarity ^@ Belongs to the MUB1/samB family.|||Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation. http://togogenome.org/gene/229533:FGSG_02668 ^@ http://purl.uniprot.org/uniprot/I1RG19 ^@ Subunit ^@ Homotetramer. http://togogenome.org/gene/229533:FGSG_05724 ^@ http://purl.uniprot.org/uniprot/I1RNX9 ^@ Similarity|||Subunit ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.|||Homotetramer. http://togogenome.org/gene/229533:FGSG_01510 ^@ http://purl.uniprot.org/uniprot/I1RD23 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/229533:FGSG_07963 ^@ http://purl.uniprot.org/uniprot/I1RUR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_13875 ^@ http://purl.uniprot.org/uniprot/I1SAJ4 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_10239 ^@ http://purl.uniprot.org/uniprot/I1S0K9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_00893 ^@ http://purl.uniprot.org/uniprot/I1RBH0 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10177 ^@ http://purl.uniprot.org/uniprot/I1S0F3 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_06927 ^@ http://purl.uniprot.org/uniprot/I1RS20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_06841 ^@ http://purl.uniprot.org/uniprot/I1RRU9 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon.|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. http://togogenome.org/gene/229533:FGSG_10069 ^@ http://purl.uniprot.org/uniprot/I1S053 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transferase hexapeptide repeat family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09031 ^@ http://purl.uniprot.org/uniprot/I1RXG2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_10265 ^@ http://purl.uniprot.org/uniprot/I1S0N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02078 ^@ http://purl.uniprot.org/uniprot/I1REI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/229533:FGSG_00380 ^@ http://purl.uniprot.org/uniprot/I1RA56 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/229533:FGSG_00558 ^@ http://purl.uniprot.org/uniprot/I1RAM6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter. http://togogenome.org/gene/229533:FGSG_12883 ^@ http://purl.uniprot.org/uniprot/I1S7Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06593 ^@ http://purl.uniprot.org/uniprot/I1RR79 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13746 ^@ http://purl.uniprot.org/uniprot/I1SA65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.|||Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_03583 ^@ http://purl.uniprot.org/uniprot/I1RIF1 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_04672 ^@ http://purl.uniprot.org/uniprot/I1RL86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10925 ^@ http://purl.uniprot.org/uniprot/I1S2D5 ^@ Similarity|||Subunit ^@ Belongs to the AlaDH/PNT family.|||Monomer. http://togogenome.org/gene/229533:FGSG_07308 ^@ http://purl.uniprot.org/uniprot/A0A1I9FPU8|||http://purl.uniprot.org/uniprot/Q4I650 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC5 family.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability.|||Nucleus http://togogenome.org/gene/229533:FGSG_06339 ^@ http://purl.uniprot.org/uniprot/I1RQJ4 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/229533:FGSG_00036 ^@ http://purl.uniprot.org/uniprot/I1R9A6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family.|||Fatty acid synthase is composed of alpha and beta subunits.|||Fatty acid synthase subunit alpha; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_02232 ^@ http://purl.uniprot.org/uniprot/I1REX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06814 ^@ http://purl.uniprot.org/uniprot/I1RRS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the timeless family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02729 ^@ http://purl.uniprot.org/uniprot/Q4IJ79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHS7 family.|||Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.|||Endoplasmic reticulum membrane|||Interacts with CHS3. http://togogenome.org/gene/229533:FGSG_01064 ^@ http://purl.uniprot.org/uniprot/I1RBX1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07502 ^@ http://purl.uniprot.org/uniprot/I1RTJ4 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_00628 ^@ http://purl.uniprot.org/uniprot/I1RAU2 ^@ Similarity ^@ Belongs to the BLOC1S1 family. http://togogenome.org/gene/229533:FGSG_00461 ^@ http://purl.uniprot.org/uniprot/I1RAD4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01669 ^@ http://purl.uniprot.org/uniprot/I1RDH3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03003 ^@ http://purl.uniprot.org/uniprot/I1RGX2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_01429 ^@ http://purl.uniprot.org/uniprot/I1RCU7 ^@ Similarity ^@ Belongs to the nucleoporin interacting component (NIC) family. http://togogenome.org/gene/229533:FGSG_13127 ^@ http://purl.uniprot.org/uniprot/I1S8E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00376 ^@ http://purl.uniprot.org/uniprot/I1RA52 ^@ Similarity ^@ Belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/229533:FGSG_00811 ^@ http://purl.uniprot.org/uniprot/V6QVS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07008 ^@ http://purl.uniprot.org/uniprot/I1RS94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_06861 ^@ http://purl.uniprot.org/uniprot/I1RRW4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_01294 ^@ http://purl.uniprot.org/uniprot/I1RCH9 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_08802 ^@ http://purl.uniprot.org/uniprot/I1RWW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07576 ^@ http://purl.uniprot.org/uniprot/I1RTR2 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_06159 ^@ http://purl.uniprot.org/uniprot/I1RQ26 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/229533:FGSG_11040 ^@ http://purl.uniprot.org/uniprot/I1S2P0 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_08614 ^@ http://purl.uniprot.org/uniprot/I1RWE8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_05802 ^@ http://purl.uniprot.org/uniprot/I1RP50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01320 ^@ http://purl.uniprot.org/uniprot/I1RCK2 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/229533:FGSG_06823 ^@ http://purl.uniprot.org/uniprot/I1RRT4 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/229533:FGSG_09259 ^@ http://purl.uniprot.org/uniprot/I1RY29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05621 ^@ http://purl.uniprot.org/uniprot/I1RNN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S9B family.|||Membrane|||Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_12029 ^@ http://purl.uniprot.org/uniprot/I1S5B1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.|||Membrane http://togogenome.org/gene/229533:FGSG_06281 ^@ http://purl.uniprot.org/uniprot/I1RQE0 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/229533:FGSG_05455 ^@ http://purl.uniprot.org/uniprot/I1RN89 ^@ Similarity ^@ Belongs to the WD repeat MET30/SCONB/SCON-2 family. http://togogenome.org/gene/229533:FGSG_02950 ^@ http://purl.uniprot.org/uniprot/I1RGS5 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_10157 ^@ http://purl.uniprot.org/uniprot/I1S0D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cut8/STS1 family.|||Binds the proteasome.|||Cytoplasm|||Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins.|||Nucleus http://togogenome.org/gene/229533:FGSG_10211 ^@ http://purl.uniprot.org/uniprot/I1S0I3 ^@ Similarity ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily. http://togogenome.org/gene/229533:FGSG_01002 ^@ http://purl.uniprot.org/uniprot/I1RBR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01245 ^@ http://purl.uniprot.org/uniprot/A0A1I9EY47|||http://purl.uniprot.org/uniprot/Q4ING3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Forms a one-to-one complex with cytochrome c.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_01640 ^@ http://purl.uniprot.org/uniprot/I1RDE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Endoplasmic reticulum membrane|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. http://togogenome.org/gene/229533:FGSG_03573 ^@ http://purl.uniprot.org/uniprot/I1RIE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_00713 ^@ http://purl.uniprot.org/uniprot/I1RB12 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08573 ^@ http://purl.uniprot.org/uniprot/I1RWB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_00309 ^@ http://purl.uniprot.org/uniprot/I1R9Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAK10 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01954 ^@ http://purl.uniprot.org/uniprot/I1RE75 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/229533:FGSG_01374 ^@ http://purl.uniprot.org/uniprot/I1RCQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG8 family.|||Membrane http://togogenome.org/gene/229533:FGSG_07047 ^@ http://purl.uniprot.org/uniprot/I1RSD1 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/229533:FGSG_07223 ^@ http://purl.uniprot.org/uniprot/I1RST9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_01917 ^@ http://purl.uniprot.org/uniprot/I1RE44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Cytoplasm|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/229533:FGSG_08937 ^@ http://purl.uniprot.org/uniprot/I1RX85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07076 ^@ http://purl.uniprot.org/uniprot/I1RSF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07186 ^@ http://purl.uniprot.org/uniprot/I1RSQ7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/229533:FGSG_02406 ^@ http://purl.uniprot.org/uniprot/I1RFD3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11922 ^@ http://purl.uniprot.org/uniprot/I1S504 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/229533:FGSG_07206 ^@ http://purl.uniprot.org/uniprot/I1RSS4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/229533:FGSG_03647 ^@ http://purl.uniprot.org/uniprot/I1RIL0 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_08343 ^@ http://purl.uniprot.org/uniprot/I1RVQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. http://togogenome.org/gene/229533:FGSG_06012 ^@ http://purl.uniprot.org/uniprot/I1RPN6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11250 ^@ http://purl.uniprot.org/uniprot/I1S380 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12974 ^@ http://purl.uniprot.org/uniprot/I1S7Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/229533:FGSG_12909 ^@ http://purl.uniprot.org/uniprot/I1S7T4 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/229533:FGSG_13176 ^@ http://purl.uniprot.org/uniprot/I1S8J8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_06022 ^@ http://purl.uniprot.org/uniprot/I1RPP6 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/229533:FGSG_00717 ^@ http://purl.uniprot.org/uniprot/A0A1I9EWC4|||http://purl.uniprot.org/uniprot/Q4IPZ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/229533:FGSG_02851 ^@ http://purl.uniprot.org/uniprot/I1RGI4 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_06020 ^@ http://purl.uniprot.org/uniprot/I1RPP4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/229533:FGSG_06334 ^@ http://purl.uniprot.org/uniprot/I1RQJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_08860 ^@ http://purl.uniprot.org/uniprot/I1RX17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Mitochondrion inner membrane|||Probably involved in the biogenesis of the COX complex. http://togogenome.org/gene/229533:FGSG_05678 ^@ http://purl.uniprot.org/uniprot/I1RNT8 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_00695 ^@ http://purl.uniprot.org/uniprot/I1RAZ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_01745 ^@ http://purl.uniprot.org/uniprot/I1RDN5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_10020 ^@ http://purl.uniprot.org/uniprot/I1S009 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. http://togogenome.org/gene/229533:FGSG_06759 ^@ http://purl.uniprot.org/uniprot/I1RRM7 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/229533:FGSG_00686 ^@ http://purl.uniprot.org/uniprot/V6R1X4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_09081 ^@ http://purl.uniprot.org/uniprot/V6RMY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07296 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKK2|||http://purl.uniprot.org/uniprot/Q4I662 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_07315 ^@ http://purl.uniprot.org/uniprot/I1RT23 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG2 family.|||C-8 sterol isomerase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG2 catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Surprisingly, does not show changed sensitivity to amines and does not lead to depletion of ergosterol. http://togogenome.org/gene/229533:FGSG_03992 ^@ http://purl.uniprot.org/uniprot/V6R5I4 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/229533:FGSG_09454 ^@ http://purl.uniprot.org/uniprot/I1RYJ8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_03439 ^@ http://purl.uniprot.org/uniprot/I1RI19 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00690 ^@ http://purl.uniprot.org/uniprot/I1RAZ3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_09309 ^@ http://purl.uniprot.org/uniprot/I1RY72 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/229533:FGSG_00684 ^@ http://purl.uniprot.org/uniprot/I1RAY8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_08312 ^@ http://purl.uniprot.org/uniprot/I1RVN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_01485 ^@ http://purl.uniprot.org/uniprot/I1RCZ8 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate 1-epimerase family.|||Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). http://togogenome.org/gene/229533:FGSG_04957 ^@ http://purl.uniprot.org/uniprot/I1RLY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09562 ^@ http://purl.uniprot.org/uniprot/I1RYV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.|||Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_09545 ^@ http://purl.uniprot.org/uniprot/I1RYT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_01586 ^@ http://purl.uniprot.org/uniprot/I1RD94 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_10862 ^@ http://purl.uniprot.org/uniprot/I1S276 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/229533:FGSG_06245 ^@ http://purl.uniprot.org/uniprot/Q4I963 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family.|||Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).|||Cytoplasm|||Nucleus matrix|||cytoskeleton http://togogenome.org/gene/229533:FGSG_10309 ^@ http://purl.uniprot.org/uniprot/I1S0S2 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/229533:FGSG_03288 ^@ http://purl.uniprot.org/uniprot/I1RHM8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/229533:FGSG_09589 ^@ http://purl.uniprot.org/uniprot/I1RYX6 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate. http://togogenome.org/gene/229533:FGSG_07067 ^@ http://purl.uniprot.org/uniprot/I1RSE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10049 ^@ http://purl.uniprot.org/uniprot/I1S035 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/229533:FGSG_05314 ^@ http://purl.uniprot.org/uniprot/A0A1I9FY03|||http://purl.uniprot.org/uniprot/Q4IBU4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).|||Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation.|||Membrane|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/229533:FGSG_06220 ^@ http://purl.uniprot.org/uniprot/I1RQ81 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/229533:FGSG_00648 ^@ http://purl.uniprot.org/uniprot/I1RAV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD3 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/229533:FGSG_05162 ^@ http://purl.uniprot.org/uniprot/I1RMH2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_05095 ^@ http://purl.uniprot.org/uniprot/I1RMA8 ^@ Function|||Similarity ^@ Belongs to the peptidase S1C family.|||Nuclear serine protease which mediates apoptosis. http://togogenome.org/gene/229533:FGSG_04596 ^@ http://purl.uniprot.org/uniprot/I1RL18 ^@ Biotechnology|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family.|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||O-methyltransferase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_11940 ^@ http://purl.uniprot.org/uniprot/I1S522 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10251 ^@ http://purl.uniprot.org/uniprot/I1S0L8 ^@ Similarity ^@ Belongs to the WD repeat LST8 family. http://togogenome.org/gene/229533:FGSG_00043 ^@ http://purl.uniprot.org/uniprot/I1R9B0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer.|||Thioredoxin reductase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_04171 ^@ http://purl.uniprot.org/uniprot/I1RJY7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/229533:FGSG_00327 ^@ http://purl.uniprot.org/uniprot/I1RA10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01624 ^@ http://purl.uniprot.org/uniprot/I1RDD0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_06922 ^@ http://purl.uniprot.org/uniprot/V6RGI1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.|||Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/229533:FGSG_07858 ^@ http://purl.uniprot.org/uniprot/I1RUG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01469 ^@ http://purl.uniprot.org/uniprot/I1RCY4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_01436 ^@ http://purl.uniprot.org/uniprot/I1RCV4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CHZ1 family.|||Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.|||Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B. http://togogenome.org/gene/229533:FGSG_02321 ^@ http://purl.uniprot.org/uniprot/I1RF55 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).|||FAD-linked oxidoreductase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||Impairs the production of aurofusarin and leads to the accumulation of a light yellow pigment (PubMed:16879655).|||Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).|||Secreted|||extracellular space http://togogenome.org/gene/229533:FGSG_09389 ^@ http://purl.uniprot.org/uniprot/I1RYE2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_09361 ^@ http://purl.uniprot.org/uniprot/I1RYB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/229533:FGSG_11557 ^@ http://purl.uniprot.org/uniprot/I1S405 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09297 ^@ http://purl.uniprot.org/uniprot/I1RY60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10744 ^@ http://purl.uniprot.org/uniprot/I1S1W9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/229533:FGSG_11342 ^@ http://purl.uniprot.org/uniprot/I1S3G1 ^@ Similarity ^@ Belongs to the CIA30 family. http://togogenome.org/gene/229533:FGSG_07018 ^@ http://purl.uniprot.org/uniprot/I1RSA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/229533:FGSG_00822 ^@ http://purl.uniprot.org/uniprot/I1RBB0 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/229533:FGSG_01433 ^@ http://purl.uniprot.org/uniprot/I1RCV1 ^@ Cofactor|||Similarity ^@ Belongs to the glutamate synthase family.|||Binds 1 [3Fe-4S] cluster. http://togogenome.org/gene/229533:FGSG_09035 ^@ http://purl.uniprot.org/uniprot/I1RXG6 ^@ Similarity ^@ Belongs to the eukaryotic AdoMetDC family. http://togogenome.org/gene/229533:FGSG_03972 ^@ http://purl.uniprot.org/uniprot/I1RJF6 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_00815 ^@ http://purl.uniprot.org/uniprot/I1RBA4 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/229533:FGSG_03727 ^@ http://purl.uniprot.org/uniprot/I1RIT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10866 ^@ http://purl.uniprot.org/uniprot/I1S280 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DLT1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Required for growth under high-pressure and low-temperature conditions. http://togogenome.org/gene/229533:FGSG_09635 ^@ http://purl.uniprot.org/uniprot/I1RZ17 ^@ Function|||Similarity ^@ Belongs to the peptidase C13 family.|||Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. http://togogenome.org/gene/229533:FGSG_09291 ^@ http://purl.uniprot.org/uniprot/V6RMM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_05011 ^@ http://purl.uniprot.org/uniprot/I1RM34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04786 ^@ http://purl.uniprot.org/uniprot/I1RLI4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06096 ^@ http://purl.uniprot.org/uniprot/I1RPW4 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/229533:FGSG_07897 ^@ http://purl.uniprot.org/uniprot/O74638 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/229533:FGSG_01463 ^@ http://purl.uniprot.org/uniprot/I1RCX9 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/229533:FGSG_04678 ^@ http://purl.uniprot.org/uniprot/I1RL92 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_10533 ^@ http://purl.uniprot.org/uniprot/I1S1D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02371 ^@ http://purl.uniprot.org/uniprot/I1RFA2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01284 ^@ http://purl.uniprot.org/uniprot/I1RCH0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00780 ^@ http://purl.uniprot.org/uniprot/I1RB73 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 1 subfamily. http://togogenome.org/gene/229533:FGSG_01281 ^@ http://purl.uniprot.org/uniprot/I1RCG7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00313 ^@ http://purl.uniprot.org/uniprot/I1R9Z6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03834 ^@ http://purl.uniprot.org/uniprot/I1RJ35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Membrane http://togogenome.org/gene/229533:FGSG_05648 ^@ http://purl.uniprot.org/uniprot/I1RNR2 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/229533:FGSG_03844 ^@ http://purl.uniprot.org/uniprot/I1RJ43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09893 ^@ http://purl.uniprot.org/uniprot/I1RZP3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit.|||Secreted http://togogenome.org/gene/229533:FGSG_04621 ^@ http://purl.uniprot.org/uniprot/I1RL41 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/229533:FGSG_07127 ^@ http://purl.uniprot.org/uniprot/I1RSK5 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/229533:FGSG_03247 ^@ http://purl.uniprot.org/uniprot/V6RDP1 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/229533:FGSG_00383 ^@ http://purl.uniprot.org/uniprot/I1RA59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_03416 ^@ http://purl.uniprot.org/uniprot/I1RHZ7 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_08561 ^@ http://purl.uniprot.org/uniprot/I1RW99 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/229533:FGSG_00665 ^@ http://purl.uniprot.org/uniprot/I1RAX1 ^@ Function|||Similarity ^@ Belongs to the dus family. Dus3 subfamily.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation. http://togogenome.org/gene/229533:FGSG_10865 ^@ http://purl.uniprot.org/uniprot/I1S279 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_05518 ^@ http://purl.uniprot.org/uniprot/I1RNE4 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/229533:FGSG_07083 ^@ http://purl.uniprot.org/uniprot/A0A1I9FLN4|||http://purl.uniprot.org/uniprot/Q4I6S5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MON1/SAND family.|||Prevacuolar compartment membrane|||Required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis.|||Vacuole membrane|||multivesicular body membrane http://togogenome.org/gene/229533:FGSG_10004 ^@ http://purl.uniprot.org/uniprot/I1RZZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 3 family.|||Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.|||Secreted http://togogenome.org/gene/229533:FGSG_09930 ^@ http://purl.uniprot.org/uniprot/I1RZS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_11457 ^@ http://purl.uniprot.org/uniprot/I1S3R2 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/229533:FGSG_03406 ^@ http://purl.uniprot.org/uniprot/I1RHY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pectinesterase family.|||Involved in maceration and soft-rotting of plant tissue.|||Secreted http://togogenome.org/gene/229533:FGSG_02301 ^@ http://purl.uniprot.org/uniprot/I1RF35 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_02848 ^@ http://purl.uniprot.org/uniprot/I1RGI2 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/229533:FGSG_01452 ^@ http://purl.uniprot.org/uniprot/I1RCW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG9 family.|||Mitochondrion|||Required for respiratory activity and maintenance and expression of the mitochondrial genome. http://togogenome.org/gene/229533:FGSG_09482 ^@ http://purl.uniprot.org/uniprot/I1RYM5 ^@ Similarity ^@ Belongs to the glyoxalase I family. http://togogenome.org/gene/229533:FGSG_01550 ^@ http://purl.uniprot.org/uniprot/I1RD61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD2 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/229533:FGSG_04240 ^@ http://purl.uniprot.org/uniprot/I1RK52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00465 ^@ http://purl.uniprot.org/uniprot/I1RAD8 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/229533:FGSG_11202 ^@ http://purl.uniprot.org/uniprot/I1S338 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/229533:FGSG_11177 ^@ http://purl.uniprot.org/uniprot/I1S316 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_02066 ^@ http://purl.uniprot.org/uniprot/I1REH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_13866 ^@ http://purl.uniprot.org/uniprot/I1SAI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05686 ^@ http://purl.uniprot.org/uniprot/I1RNU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_05301 ^@ http://purl.uniprot.org/uniprot/I1RMV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. http://togogenome.org/gene/229533:FGSG_00866 ^@ http://purl.uniprot.org/uniprot/I1RBE8 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/229533:FGSG_04783 ^@ http://purl.uniprot.org/uniprot/I1RLI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05028 ^@ http://purl.uniprot.org/uniprot/I1RM49 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Also essential during biosynthesis of the molybdenum cofactor. Acts by mediating the C-terminal thiocarboxylation of sulfur carriers urm1 and MOCS2A. Its N-terminus first activates urm1 and MOCS2A as acyl-adenylates (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to urm1 and MOCS2A to form thiocarboxylation (-COSH) of their C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards urm1 and MOCS2A. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; nfs1 probably acting as a sulfur donor for thiocarboxylation reactions. http://togogenome.org/gene/229533:FGSG_03912 ^@ http://purl.uniprot.org/uniprot/I1RJA3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09663 ^@ http://purl.uniprot.org/uniprot/I1RZ40 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/229533:FGSG_01567 ^@ http://purl.uniprot.org/uniprot/A0A1I9EZ77|||http://purl.uniprot.org/uniprot/Q4IMJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. Adenine deaminase type 2 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of adenine to hypoxanthine. Plays an important role in the purine salvage pathway and in nitrogen catabolism.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_07395 ^@ http://purl.uniprot.org/uniprot/I1RT94 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/229533:FGSG_10963 ^@ http://purl.uniprot.org/uniprot/I1S2G9 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/229533:FGSG_02502 ^@ http://purl.uniprot.org/uniprot/I1RFM2 ^@ Disruption Phenotype|||Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family.|||C-5 sterol desaturase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:24785759). ERG3A and ERG3BB catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Leads to a severe decrease in ergosterol production and virulence when ERG3B is also deleted (PubMed:23442154). Results in increased production of deoxynivalenol (DON) (PubMed:24785759).|||The histidine box domains may contain the active site and/or be involved in metal ion binding. http://togogenome.org/gene/229533:FGSG_05389 ^@ http://purl.uniprot.org/uniprot/I1RN28 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/229533:FGSG_12485 ^@ http://purl.uniprot.org/uniprot/I1S6L3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04872 ^@ http://purl.uniprot.org/uniprot/I1RLQ8 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_00337 ^@ http://purl.uniprot.org/uniprot/I1RA20 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_10858 ^@ http://purl.uniprot.org/uniprot/I1S272 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum. http://togogenome.org/gene/229533:FGSG_00870 ^@ http://purl.uniprot.org/uniprot/I1RBF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/229533:FGSG_11024 ^@ http://purl.uniprot.org/uniprot/I1S2M5 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Results in increased sensitivity to tebuconazole, diniconazole, difenoconazole, flutriafol and prochloraz, but not to triadimefon and propiconazole (PubMed:20955812). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Reduces virulence on host wheat ears (PubMed:23442154). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).|||Endoplasmic reticulum membrane|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol 14-alpha demethylase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:20955812). CYP51C, does not seem to encode an active sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears (PubMed:20955812). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_01299 ^@ http://purl.uniprot.org/uniprot/I1RCI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06832 ^@ http://purl.uniprot.org/uniprot/I1RRU2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_10677 ^@ http://purl.uniprot.org/uniprot/I1S1R2 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/229533:FGSG_03984 ^@ http://purl.uniprot.org/uniprot/I1RJG4 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00800 ^@ http://purl.uniprot.org/uniprot/I1RB90 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11657 ^@ http://purl.uniprot.org/uniprot/I1S490 ^@ Function ^@ Part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_05546 ^@ http://purl.uniprot.org/uniprot/I1RNG7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_07892 ^@ http://purl.uniprot.org/uniprot/I1RUJ7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/229533:FGSG_00825 ^@ http://purl.uniprot.org/uniprot/I1RBB3 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/229533:FGSG_08758 ^@ http://purl.uniprot.org/uniprot/I1RWS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_05164 ^@ http://purl.uniprot.org/uniprot/I1RMH4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_11562 ^@ http://purl.uniprot.org/uniprot/I1S410 ^@ Similarity ^@ Belongs to the tannase family. http://togogenome.org/gene/229533:FGSG_06349 ^@ http://purl.uniprot.org/uniprot/I1RQK4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_08996 ^@ http://purl.uniprot.org/uniprot/I1RXD0 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/229533:FGSG_00371 ^@ http://purl.uniprot.org/uniprot/I1RA47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01397 ^@ http://purl.uniprot.org/uniprot/I1RCS1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/229533:FGSG_01342 ^@ http://purl.uniprot.org/uniprot/I1RCM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alternative oxidase family.|||Binds 2 iron ions per subunit.|||Catalyzes cyanide-resistant oxygen consumption. May increase respiration when the cytochrome respiratory pathway is restricted, or in response to low temperatures.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00387 ^@ http://purl.uniprot.org/uniprot/I1RA62 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/229533:FGSG_10114 ^@ http://purl.uniprot.org/uniprot/I1S095 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/229533:FGSG_06444 ^@ http://purl.uniprot.org/uniprot/I1RQU4 ^@ Similarity ^@ Belongs to the trichodiene synthase family. http://togogenome.org/gene/229533:FGSG_06427 ^@ http://purl.uniprot.org/uniprot/I1RQS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_13064 ^@ http://purl.uniprot.org/uniprot/I1S886 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/229533:FGSG_10809 ^@ http://purl.uniprot.org/uniprot/I1S228 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13984 ^@ http://purl.uniprot.org/uniprot/I1SAV3 ^@ Similarity ^@ Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_01312 ^@ http://purl.uniprot.org/uniprot/I1RCJ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_03508 ^@ http://purl.uniprot.org/uniprot/I1RI81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00069 ^@ http://purl.uniprot.org/uniprot/I1R9D4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01929 ^@ http://purl.uniprot.org/uniprot/I1RE55 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/229533:FGSG_04398 ^@ http://purl.uniprot.org/uniprot/I1RKJ2 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_10716 ^@ http://purl.uniprot.org/uniprot/A0A1I9FUR3|||http://purl.uniprot.org/uniprot/Q4HWE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Nucleus|||Possesses 5'->3' exoribonuclease activity. May promote termination of transcription by RNA polymerase II.|||Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity).|||Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/229533:FGSG_08532 ^@ http://purl.uniprot.org/uniprot/I1RW71 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. http://togogenome.org/gene/229533:FGSG_06126 ^@ http://purl.uniprot.org/uniprot/I1RPZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11366 ^@ http://purl.uniprot.org/uniprot/I1S3I2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_04996 ^@ http://purl.uniprot.org/uniprot/I1RM21 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Belongs to the Clp1 family. NOL9/GRC3 subfamily.|||Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.|||May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.|||Nucleus|||Polynucleotide 5'-kinase involved in rRNA processing.|||Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. http://togogenome.org/gene/229533:FGSG_06755 ^@ http://purl.uniprot.org/uniprot/I1RRM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_03343 ^@ http://purl.uniprot.org/uniprot/I1RHT0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/229533:FGSG_13426 ^@ http://purl.uniprot.org/uniprot/I1S996 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01081 ^@ http://purl.uniprot.org/uniprot/I1RBY4 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. http://togogenome.org/gene/229533:FGSG_06702 ^@ http://purl.uniprot.org/uniprot/V6RLM7 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_02279 ^@ http://purl.uniprot.org/uniprot/I1RF16 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/229533:FGSG_08615 ^@ http://purl.uniprot.org/uniprot/I1RWE9 ^@ Subunit ^@ Component of the ESCRT-0 complex composed of HSE1 and VPS27. http://togogenome.org/gene/229533:FGSG_10793 ^@ http://purl.uniprot.org/uniprot/I1S212 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family. http://togogenome.org/gene/229533:FGSG_10404 ^@ http://purl.uniprot.org/uniprot/I1S111 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/229533:FGSG_04998 ^@ http://purl.uniprot.org/uniprot/I1RM23 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/229533:FGSG_12692 ^@ http://purl.uniprot.org/uniprot/I1S769 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_04416 ^@ http://purl.uniprot.org/uniprot/I1RKK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_09728 ^@ http://purl.uniprot.org/uniprot/I1RZ98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07404 ^@ http://purl.uniprot.org/uniprot/I1RTA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the calcineurin regulatory subunit family.|||Composed of a catalytic subunit (A) and a regulatory subunit (B).|||Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity. http://togogenome.org/gene/229533:FGSG_00059 ^@ http://purl.uniprot.org/uniprot/I1R9C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10210 ^@ http://purl.uniprot.org/uniprot/I1S0I2 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_01254 ^@ http://purl.uniprot.org/uniprot/I1RCE4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/229533:FGSG_04111 ^@ http://purl.uniprot.org/uniprot/I1RJS9 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_08058 ^@ http://purl.uniprot.org/uniprot/I1RUZ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00677 ^@ http://purl.uniprot.org/uniprot/I1RAY2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_03035 ^@ http://purl.uniprot.org/uniprot/I1RH01 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/229533:FGSG_02015 ^@ http://purl.uniprot.org/uniprot/I1REC8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_11339 ^@ http://purl.uniprot.org/uniprot/I1S3F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01746 ^@ http://purl.uniprot.org/uniprot/I1RDN6 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/229533:FGSG_03725 ^@ http://purl.uniprot.org/uniprot/I1RIT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10708 ^@ http://purl.uniprot.org/uniprot/I1S1T8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_05739 ^@ http://purl.uniprot.org/uniprot/I1RNZ2 ^@ Similarity ^@ Belongs to the Cyclase 1 superfamily. http://togogenome.org/gene/229533:FGSG_09319 ^@ http://purl.uniprot.org/uniprot/I1RY80 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/229533:FGSG_04969 ^@ http://purl.uniprot.org/uniprot/I1RLZ7 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_00608 ^@ http://purl.uniprot.org/uniprot/I1RAS3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/229533:FGSG_05668 ^@ http://purl.uniprot.org/uniprot/V6RAN2 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/229533:FGSG_08417 ^@ http://purl.uniprot.org/uniprot/I1RVX0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/229533:FGSG_03614 ^@ http://purl.uniprot.org/uniprot/I1RII1 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/229533:FGSG_11337 ^@ http://purl.uniprot.org/uniprot/I1S3F7 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/229533:FGSG_12728 ^@ http://purl.uniprot.org/uniprot/I1S7A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10148 ^@ http://purl.uniprot.org/uniprot/I1S0C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/229533:FGSG_00373 ^@ http://purl.uniprot.org/uniprot/I1RA49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase B chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11697 ^@ http://purl.uniprot.org/uniprot/I1S4D0 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/229533:FGSG_12839 ^@ http://purl.uniprot.org/uniprot/I1S7L6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/229533:FGSG_06548 ^@ http://purl.uniprot.org/uniprot/I1RR39 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05267 ^@ http://purl.uniprot.org/uniprot/I1RMS0 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/229533:FGSG_02780 ^@ http://purl.uniprot.org/uniprot/I1RGC1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/229533:FGSG_05489 ^@ http://purl.uniprot.org/uniprot/V6R9Z0 ^@ Subcellular Location Annotation|||Subunit ^@ Component of the mitochondrial large ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_09796 ^@ http://purl.uniprot.org/uniprot/I1RZF7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04313 ^@ http://purl.uniprot.org/uniprot/I1RKB5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/229533:FGSG_06695 ^@ http://purl.uniprot.org/uniprot/I1RRH4 ^@ Function ^@ Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). http://togogenome.org/gene/229533:FGSG_05120 ^@ http://purl.uniprot.org/uniprot/I1RMD1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07319 ^@ http://purl.uniprot.org/uniprot/I1RT27 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_10291 ^@ http://purl.uniprot.org/uniprot/I1S0Q5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05411 ^@ http://purl.uniprot.org/uniprot/I1RN48 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/229533:FGSG_01831 ^@ http://purl.uniprot.org/uniprot/I1RDW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cerato-ulmin hydrophobin family.|||cell wall http://togogenome.org/gene/229533:FGSG_01558 ^@ http://purl.uniprot.org/uniprot/I1RD69 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/229533:FGSG_00509 ^@ http://purl.uniprot.org/uniprot/I1RAH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09020 ^@ http://purl.uniprot.org/uniprot/I1RXF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_01100 ^@ http://purl.uniprot.org/uniprot/I1RC01 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10352 ^@ http://purl.uniprot.org/uniprot/A0A1I9F5I2|||http://purl.uniprot.org/uniprot/Q4HXF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/229533:FGSG_05415 ^@ http://purl.uniprot.org/uniprot/I1RN51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/229533:FGSG_03812 ^@ http://purl.uniprot.org/uniprot/I1RJ13 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_09484 ^@ http://purl.uniprot.org/uniprot/I1RYM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03994 ^@ http://purl.uniprot.org/uniprot/I1RJH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_10570 ^@ http://purl.uniprot.org/uniprot/I1S1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03144 ^@ http://purl.uniprot.org/uniprot/I1RH99 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_04676 ^@ http://purl.uniprot.org/uniprot/I1RL90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08831 ^@ http://purl.uniprot.org/uniprot/I1RWZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03306 ^@ http://purl.uniprot.org/uniprot/I1RHP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11358 ^@ http://purl.uniprot.org/uniprot/I1S3H6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08761 ^@ http://purl.uniprot.org/uniprot/V6RRH2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_03201 ^@ http://purl.uniprot.org/uniprot/I1RHF1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04413 ^@ http://purl.uniprot.org/uniprot/V6R398 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_11038 ^@ http://purl.uniprot.org/uniprot/I1S2N8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09503 ^@ http://purl.uniprot.org/uniprot/I1RYP5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/229533:FGSG_09726 ^@ http://purl.uniprot.org/uniprot/I1RZ96 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00408 ^@ http://purl.uniprot.org/uniprot/I1RA81 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/229533:FGSG_04412 ^@ http://purl.uniprot.org/uniprot/I1RKK2 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/229533:FGSG_11743 ^@ http://purl.uniprot.org/uniprot/I1S4H6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM12 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_08834 ^@ http://purl.uniprot.org/uniprot/I1RWZ4 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/229533:FGSG_04546 ^@ http://purl.uniprot.org/uniprot/I1RKX5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/229533:FGSG_00921 ^@ http://purl.uniprot.org/uniprot/I1RBJ6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/229533:FGSG_07413 ^@ http://purl.uniprot.org/uniprot/I1RTB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08378 ^@ http://purl.uniprot.org/uniprot/I1RVT5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Chalcone/stilbene synthases family. http://togogenome.org/gene/229533:FGSG_06611 ^@ http://purl.uniprot.org/uniprot/I1RR95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_05848 ^@ http://purl.uniprot.org/uniprot/I1RP91 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03279 ^@ http://purl.uniprot.org/uniprot/I1RHM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_09689 ^@ http://purl.uniprot.org/uniprot/I1RZ63 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/229533:FGSG_00116 ^@ http://purl.uniprot.org/uniprot/I1R9H5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02527 ^@ http://purl.uniprot.org/uniprot/I1RFP4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09017 ^@ http://purl.uniprot.org/uniprot/I1RXF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07453 ^@ http://purl.uniprot.org/uniprot/I1RTF0 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/229533:FGSG_00593 ^@ http://purl.uniprot.org/uniprot/I1RAQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13457 ^@ http://purl.uniprot.org/uniprot/I1S9C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11082 ^@ http://purl.uniprot.org/uniprot/I1S2S9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_01018 ^@ http://purl.uniprot.org/uniprot/I1RBS8 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/229533:FGSG_09968 ^@ http://purl.uniprot.org/uniprot/I1RZW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00712 ^@ http://purl.uniprot.org/uniprot/V6QW87 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_12647 ^@ http://purl.uniprot.org/uniprot/I1S724 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/229533:FGSG_06537 ^@ http://purl.uniprot.org/uniprot/I1RR30 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_05829 ^@ http://purl.uniprot.org/uniprot/I1RP75 ^@ Similarity ^@ Belongs to the peptidase S9C family. http://togogenome.org/gene/229533:FGSG_06203 ^@ http://purl.uniprot.org/uniprot/I1RQ65 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.|||nucleolus http://togogenome.org/gene/229533:FGSG_07062 ^@ http://purl.uniprot.org/uniprot/I1RSE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00657 ^@ http://purl.uniprot.org/uniprot/I1RAW4 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. LaeA methyltransferase family.|||Component of the heterotrimeric velvet complex composed of laeA, ve1 and velB; Ve1 acting as a bridging protein between laeA and velB (By similarity). Interacts directly with veA (PubMed:23874628).|||Constitutively expressed under both trichothecenes mycotoxin production and sexual development conditions (PubMed:23874628).|||Cytoplasm|||Methyltransferase that performs automethylation (By similarity). No other methyl-accepting substrate has been identified yet (By similarity). Component of the velvet transcription factor complex that acts as a global regulator for secondary metabolite gene expression (PubMed:23874628). Controls the expression of the mycotoxins trichothecenes and zearalenon gene clusters (PubMed:23874628). Negatively controls perithecial induction, but positively controls virulence toward the host plant (PubMed:23874628).|||Nucleus|||Reduces strongly expression of the transcription factors TRI6 and ZEB2 that control the biosynthesis of the mycotoxins trichothecenes and zearalenon, respectively (PubMed:23874628). Exhibits an earlier induction of sexual fruiting body (perithecia) formation and drastically reduces disease symptoms in wheat (PubMed:23874628). http://togogenome.org/gene/229533:FGSG_09643 ^@ http://purl.uniprot.org/uniprot/I1RZ25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Peroxisome http://togogenome.org/gene/229533:FGSG_01480 ^@ http://purl.uniprot.org/uniprot/I1RCZ3 ^@ Similarity ^@ Belongs to the SEN54 family. http://togogenome.org/gene/229533:FGSG_10741 ^@ http://purl.uniprot.org/uniprot/I1S1W6 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. gTMT family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00904 ^@ http://purl.uniprot.org/uniprot/I1RBH9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dUTPase family.|||Homotrimer.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/229533:FGSG_02764 ^@ http://purl.uniprot.org/uniprot/I1RGA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/229533:FGSG_03702 ^@ http://purl.uniprot.org/uniprot/I1RIR0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05220 ^@ http://purl.uniprot.org/uniprot/I1RMM7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/229533:FGSG_02763 ^@ http://purl.uniprot.org/uniprot/I1RGA5 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/229533:FGSG_02924 ^@ http://purl.uniprot.org/uniprot/I1RGQ1 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_08757 ^@ http://purl.uniprot.org/uniprot/I1RWS7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 81 family. http://togogenome.org/gene/229533:FGSG_06708 ^@ http://purl.uniprot.org/uniprot/I1RRI5 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_09422 ^@ http://purl.uniprot.org/uniprot/V6RN44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_09961 ^@ http://purl.uniprot.org/uniprot/I1RZV6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_04636 ^@ http://purl.uniprot.org/uniprot/V6R3D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04459 ^@ http://purl.uniprot.org/uniprot/I1RKP6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00175 ^@ http://purl.uniprot.org/uniprot/I1R9M6 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/229533:FGSG_02602 ^@ http://purl.uniprot.org/uniprot/I1RFW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H3 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07141 ^@ http://purl.uniprot.org/uniprot/I1RSL8 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/229533:FGSG_05286 ^@ http://purl.uniprot.org/uniprot/V6R9X9 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/229533:FGSG_05674 ^@ http://purl.uniprot.org/uniprot/I1RNT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11542 ^@ http://purl.uniprot.org/uniprot/V6R1D2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05224 ^@ http://purl.uniprot.org/uniprot/I1RMN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_08693 ^@ http://purl.uniprot.org/uniprot/I1RWL8 ^@ Similarity ^@ Belongs to the LipB family. http://togogenome.org/gene/229533:FGSG_00458 ^@ http://purl.uniprot.org/uniprot/I1RAD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_01190 ^@ http://purl.uniprot.org/uniprot/I1RC87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11846 ^@ http://purl.uniprot.org/uniprot/I1S4S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_03217 ^@ http://purl.uniprot.org/uniprot/I1RHG4 ^@ Similarity ^@ Belongs to the tannase family. http://togogenome.org/gene/229533:FGSG_11915 ^@ http://purl.uniprot.org/uniprot/I1S4Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Participates in the folding of proteins containing disulfide bonds, may be involved in glycosylation, prolyl hydroxylation and triglyceride transfer. http://togogenome.org/gene/229533:FGSG_07564 ^@ http://purl.uniprot.org/uniprot/I1RTQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06198 ^@ http://purl.uniprot.org/uniprot/I1RQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family.|||Cell membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_00430 ^@ http://purl.uniprot.org/uniprot/I1RAA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/229533:FGSG_01791 ^@ http://purl.uniprot.org/uniprot/I1RDS6 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/229533:FGSG_07542 ^@ http://purl.uniprot.org/uniprot/I1RTN1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 51 family. http://togogenome.org/gene/229533:FGSG_01290 ^@ http://purl.uniprot.org/uniprot/I1RCH5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/229533:FGSG_05651 ^@ http://purl.uniprot.org/uniprot/I1RNR5 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/229533:FGSG_10836 ^@ http://purl.uniprot.org/uniprot/I1S252 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/229533:FGSG_02398 ^@ http://purl.uniprot.org/uniprot/I1RFC6 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).|||Impairs the expression of the zearalenone biosynthesis cluster genes and results in the loss of beta-zearalenonol and zearalenone production (PubMed:16262793).|||Nucleus|||Transcription factor that specifically controls transcription of the zearalenone biosynthesis cluster genes (PubMed:16262793). http://togogenome.org/gene/229533:FGSG_00871 ^@ http://purl.uniprot.org/uniprot/I1RBF3 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/229533:FGSG_09991 ^@ http://purl.uniprot.org/uniprot/I1RZY1 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/229533:FGSG_07544 ^@ http://purl.uniprot.org/uniprot/I1RTN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04709 ^@ http://purl.uniprot.org/uniprot/I1RLC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03426 ^@ http://purl.uniprot.org/uniprot/I1RI07 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02040 ^@ http://purl.uniprot.org/uniprot/I1REF2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/229533:FGSG_02491 ^@ http://purl.uniprot.org/uniprot/I1RFL2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/229533:FGSG_10221 ^@ http://purl.uniprot.org/uniprot/I1S0J3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06184 ^@ http://purl.uniprot.org/uniprot/I1RQ48 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Expected to bind 2 Fe(2+) ions per subunit.|||Membrane|||Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. http://togogenome.org/gene/229533:FGSG_01391 ^@ http://purl.uniprot.org/uniprot/I1RCR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02992 ^@ http://purl.uniprot.org/uniprot/I1RGW1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11548 ^@ http://purl.uniprot.org/uniprot/I1S3Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_00757 ^@ http://purl.uniprot.org/uniprot/I1RB50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00067 ^@ http://purl.uniprot.org/uniprot/I1R9D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00806 ^@ http://purl.uniprot.org/uniprot/I1RB96 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_09148 ^@ http://purl.uniprot.org/uniprot/I1RXS3 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/229533:FGSG_01107 ^@ http://purl.uniprot.org/uniprot/I1RC08 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. MOCOS subfamily.|||Sulfurates the molybdenum cofactor. Sulfation of molybdenum is essential for xanthine dehydrogenase (XDH) and aldehyde oxidase (ADO) enzymes in which molybdenum cofactor is liganded by 1 oxygen and 1 sulfur atom in active form. http://togogenome.org/gene/229533:FGSG_05491 ^@ http://purl.uniprot.org/uniprot/V6R3L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/229533:FGSG_08696 ^@ http://purl.uniprot.org/uniprot/I1RWM0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10634 ^@ http://purl.uniprot.org/uniprot/I1S1M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_12131 ^@ http://purl.uniprot.org/uniprot/I1S5L0 ^@ Function ^@ Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. http://togogenome.org/gene/229533:FGSG_05085 ^@ http://purl.uniprot.org/uniprot/I1RMA0 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/229533:FGSG_10524 ^@ http://purl.uniprot.org/uniprot/I1S1C4 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/229533:FGSG_03882 ^@ http://purl.uniprot.org/uniprot/I1RJ75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_07247 ^@ http://purl.uniprot.org/uniprot/I1RSW2 ^@ Similarity ^@ Belongs to the NSRP1 family. http://togogenome.org/gene/229533:FGSG_07144 ^@ http://purl.uniprot.org/uniprot/I1RSM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02381 ^@ http://purl.uniprot.org/uniprot/I1RFB2 ^@ Similarity ^@ Belongs to the peptidase S1B family. http://togogenome.org/gene/229533:FGSG_06918 ^@ http://purl.uniprot.org/uniprot/I1RS14 ^@ Function|||Similarity ^@ Belongs to the GMC oxidoreductase family.|||Long-chain fatty alcohol oxidase involved in the omega-oxidation pathway of lipid degradation. http://togogenome.org/gene/229533:FGSG_03652 ^@ http://purl.uniprot.org/uniprot/I1RIL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11032 ^@ http://purl.uniprot.org/uniprot/I1S2N3 ^@ Cofactor|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Cu(2+) ion per subunit.|||Catalyzes the sterospecific oxidation of primary alcohols to the corresponding aldehydes. The biologically relevant substrate of the enzyme is not known as the enzyme exhibits broad substrate specificity from small alcohols through sugars to oligo- and polysaccharides (By similarity).|||Galactose oxidase contains a protein-derived free radical cofactor (By similarity). In the active state, Tyr-313, which is cross-linked to Cys-269 via a thioether bond, is oxidized to a radical and acts with Cu(2+) as a two-electron acceptor in the oxidation reaction. The cross-link is believed to modulate the redox potential of the tyrosyl radical, which is further stabilized by a stacking interaction with Trp-331 in the active site. The post-translational formation of the cross-link is closely linked to the propeptide cleavage event, and both are copper-dependent, autocatalytic processes. The propeptide may act as an intramolecular chaperone, facilitating thioester bond formation and copper binding by positioning of active-site residues, including copper ligands (By similarity).|||Monomer.|||Secreted http://togogenome.org/gene/229533:FGSG_07000 ^@ http://purl.uniprot.org/uniprot/I1RS87 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_05707 ^@ http://purl.uniprot.org/uniprot/I1RNW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10941 ^@ http://purl.uniprot.org/uniprot/I1S2E9 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/229533:FGSG_04305 ^@ http://purl.uniprot.org/uniprot/I1RKA8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01371 ^@ http://purl.uniprot.org/uniprot/I1RCP7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/229533:FGSG_03777 ^@ http://purl.uniprot.org/uniprot/I1RIY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Catalyzes the conversion of dihydroorotate to orotate with fumarate as the electron acceptor.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/229533:FGSG_07059 ^@ http://purl.uniprot.org/uniprot/I1RSE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_04220 ^@ http://purl.uniprot.org/uniprot/I1RK32 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00481 ^@ http://purl.uniprot.org/uniprot/I1RAF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00405 ^@ http://purl.uniprot.org/uniprot/I1RA78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00433 ^@ http://purl.uniprot.org/uniprot/I1RAA6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/229533:FGSG_07254 ^@ http://purl.uniprot.org/uniprot/A0A1I9FN00|||http://purl.uniprot.org/uniprot/Q4I6A4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates Lys-12 of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.|||Catalytic component of the histone acetylase B (HAT-B) complex. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_09783 ^@ http://purl.uniprot.org/uniprot/I1RZE4 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the proteasome subunit S2 family. http://togogenome.org/gene/229533:FGSG_06536 ^@ http://purl.uniprot.org/uniprot/I1RR29 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_04876 ^@ http://purl.uniprot.org/uniprot/I1RLR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_00308 ^@ http://purl.uniprot.org/uniprot/I1R9Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10845 ^@ http://purl.uniprot.org/uniprot/I1S261 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/229533:FGSG_02540 ^@ http://purl.uniprot.org/uniprot/I1RFQ5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05207 ^@ http://purl.uniprot.org/uniprot/I1RML5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08040 ^@ http://purl.uniprot.org/uniprot/I1RUY1 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_05016 ^@ http://purl.uniprot.org/uniprot/V6RAC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_08729 ^@ http://purl.uniprot.org/uniprot/I1RWQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_10604 ^@ http://purl.uniprot.org/uniprot/I1S1J9 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_01017 ^@ http://purl.uniprot.org/uniprot/I1RBS7 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/229533:FGSG_02528 ^@ http://purl.uniprot.org/uniprot/A0A1I9F214|||http://purl.uniprot.org/uniprot/Q4IJT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).|||Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_10145 ^@ http://purl.uniprot.org/uniprot/I1S0C3 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/229533:FGSG_00685 ^@ http://purl.uniprot.org/uniprot/I1RAY9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_12631 ^@ http://purl.uniprot.org/uniprot/I1S708 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02323 ^@ http://purl.uniprot.org/uniprot/I1RF57 ^@ Function|||Induction|||Subcellular Location Annotation ^@ Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription facto aurR1/GIP2 (PubMed:16461721).|||Nucleus|||Transcription factor that may participate in the regulation of the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:16879655, PubMed:16461721). http://togogenome.org/gene/229533:FGSG_03645 ^@ http://purl.uniprot.org/uniprot/I1RIK8 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. GlucD subfamily. http://togogenome.org/gene/229533:FGSG_04983 ^@ http://purl.uniprot.org/uniprot/I1RM10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/229533:FGSG_12641 ^@ http://purl.uniprot.org/uniprot/I1S718 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09535 ^@ http://purl.uniprot.org/uniprot/I1RYS6 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/229533:FGSG_09633 ^@ http://purl.uniprot.org/uniprot/I1RZ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01013 ^@ http://purl.uniprot.org/uniprot/I1RBS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/229533:FGSG_09734 ^@ http://purl.uniprot.org/uniprot/I1RZA4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13450 ^@ http://purl.uniprot.org/uniprot/I1S9C0 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_06510 ^@ http://purl.uniprot.org/uniprot/I1RR07 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophagy-specific protein that functions with ATG13, ATG29, and CIS1/ATG31 in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation (By similarity). Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles, through interacting with and regulating ATG1 kinase activity (By similarity). Plays particularly a role in pexophagy and nucleophagy (By similarity). With ATG13, is required for ATG1 activation by autophosphorylation (By similarity). Recruits ATG9 to the pre-autophagosomal structure (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Belongs to the ATG17 family.|||Cytoplasm|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).|||Forms a complex with ATG13, ATG29 and CIS1/ATG31 (By similarity). The ATG17-ATG29-ATG31 complex interacts with the ATG1-ATG13 complex (By similarity). Forms a complex with SNX4 and ATG20 (By similarity). Interacts with ATG11 (By similarity).|||Preautophagosomal structure membrane http://togogenome.org/gene/229533:FGSG_02244 ^@ http://purl.uniprot.org/uniprot/I1REY5 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/229533:FGSG_00510 ^@ http://purl.uniprot.org/uniprot/I1RAI0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_08987 ^@ http://purl.uniprot.org/uniprot/I1RXC3 ^@ Function|||Similarity ^@ Belongs to the LCL2 family.|||Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. http://togogenome.org/gene/229533:FGSG_09045 ^@ http://purl.uniprot.org/uniprot/I1RXH6 ^@ Similarity ^@ Belongs to the CbxX/CfxQ family. http://togogenome.org/gene/229533:FGSG_05475 ^@ http://purl.uniprot.org/uniprot/I1RNA7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10050 ^@ http://purl.uniprot.org/uniprot/I1S036 ^@ Similarity ^@ Belongs to the UPF0337 (CsbD) family. http://togogenome.org/gene/229533:FGSG_11468 ^@ http://purl.uniprot.org/uniprot/I1S3S2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_10418 ^@ http://purl.uniprot.org/uniprot/I1S124 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family.|||Belongs to the glycosyltransferase 77 family. http://togogenome.org/gene/229533:FGSG_11316 ^@ http://purl.uniprot.org/uniprot/I1S3D8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00905 ^@ http://purl.uniprot.org/uniprot/I1RBI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_03080 ^@ http://purl.uniprot.org/uniprot/I1RH39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02688 ^@ http://purl.uniprot.org/uniprot/I1RG39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02493 ^@ http://purl.uniprot.org/uniprot/I1RFL4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/229533:FGSG_06509 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKF3|||http://purl.uniprot.org/uniprot/Q4I8E9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Membrane|||Probably involved in transport through the plasma membrane. http://togogenome.org/gene/229533:FGSG_09931 ^@ http://purl.uniprot.org/uniprot/V6RQ28 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_06850 ^@ http://purl.uniprot.org/uniprot/I1RRV4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_06523 ^@ http://purl.uniprot.org/uniprot/I1RR19 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/229533:FGSG_04105 ^@ http://purl.uniprot.org/uniprot/I1RJS3 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/229533:FGSG_04976 ^@ http://purl.uniprot.org/uniprot/I1RM04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11677 ^@ http://purl.uniprot.org/uniprot/I1S4B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PC-esterase family. CASD1 subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_04225 ^@ http://purl.uniprot.org/uniprot/I1RK37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-L/IML3 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02506 ^@ http://purl.uniprot.org/uniprot/I1RFM6 ^@ Function|||Similarity ^@ Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.|||In the C-terminal section; belongs to the AIR synthase family.|||In the N-terminal section; belongs to the GARS family. http://togogenome.org/gene/229533:FGSG_11260 ^@ http://purl.uniprot.org/uniprot/V6RWE8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00572 ^@ http://purl.uniprot.org/uniprot/I1RAP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09738 ^@ http://purl.uniprot.org/uniprot/I1RZA6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06529 ^@ http://purl.uniprot.org/uniprot/Q4I8C9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar4-20 subfamily.|||Chromosome|||Histone methyltransferase that trimethylates 'Lys-20' of histone H4 to form H4K20me3.|||Nucleus http://togogenome.org/gene/229533:FGSG_03842 ^@ http://purl.uniprot.org/uniprot/I1RJ42 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/229533:FGSG_08206 ^@ http://purl.uniprot.org/uniprot/I1RVD6 ^@ Function ^@ Part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable). http://togogenome.org/gene/229533:FGSG_12341 ^@ http://purl.uniprot.org/uniprot/I1S670 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02974 ^@ http://purl.uniprot.org/uniprot/I1RGU6 ^@ Caution|||Cofactor|||PTM|||Similarity ^@ Belongs to the peroxidase family. Peroxidase/catalase subfamily.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per monomer.|||Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_05439 ^@ http://purl.uniprot.org/uniprot/I1RN73 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/229533:FGSG_10894 ^@ http://purl.uniprot.org/uniprot/I1S2A8 ^@ Function|||Similarity ^@ Belongs to the exportin family.|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease. http://togogenome.org/gene/229533:FGSG_11480 ^@ http://purl.uniprot.org/uniprot/I1S3T3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06822 ^@ http://purl.uniprot.org/uniprot/I1RRT3 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/229533:FGSG_02314 ^@ http://purl.uniprot.org/uniprot/I1RF48 ^@ Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Monomer. http://togogenome.org/gene/229533:FGSG_01293 ^@ http://purl.uniprot.org/uniprot/I1RCH8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04185 ^@ http://purl.uniprot.org/uniprot/I1RK01 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family. http://togogenome.org/gene/229533:FGSG_03107 ^@ http://purl.uniprot.org/uniprot/I1RH63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02094 ^@ http://purl.uniprot.org/uniprot/V6QZS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_06177 ^@ http://purl.uniprot.org/uniprot/I1RQ41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_08082 ^@ http://purl.uniprot.org/uniprot/I1RV22 ^@ Function|||Induction|||Similarity ^@ Belongs to the acetyltransferase family.|||Highly expressed under trichothecene-producing conditions.|||Putative acetyltransferase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable). http://togogenome.org/gene/229533:FGSG_04426 ^@ http://purl.uniprot.org/uniprot/I1RKL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09511 ^@ http://purl.uniprot.org/uniprot/I1RYQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I NDUFB11 subunit family.|||Membrane http://togogenome.org/gene/229533:FGSG_08932 ^@ http://purl.uniprot.org/uniprot/Q4I1H6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasm|||Golgi apparatus membrane|||Prevacuolar compartment membrane|||Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. http://togogenome.org/gene/229533:FGSG_03796 ^@ http://purl.uniprot.org/uniprot/I1RIZ8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_05935 ^@ http://purl.uniprot.org/uniprot/I1RPG6 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_07938 ^@ http://purl.uniprot.org/uniprot/I1RUN8 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/229533:FGSG_01135 ^@ http://purl.uniprot.org/uniprot/I1RC33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/229533:FGSG_10227 ^@ http://purl.uniprot.org/uniprot/I1S0J8 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/229533:FGSG_00269 ^@ http://purl.uniprot.org/uniprot/V6QT89 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/229533:FGSG_12548 ^@ http://purl.uniprot.org/uniprot/I1S6S5 ^@ Similarity ^@ Belongs to the tannase family. http://togogenome.org/gene/229533:FGSG_12444 ^@ http://purl.uniprot.org/uniprot/I1S6H3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. S-2-haloalkanoic acid dehalogenase family. http://togogenome.org/gene/229533:FGSG_07846 ^@ http://purl.uniprot.org/uniprot/I1RUF5 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_07409 ^@ http://purl.uniprot.org/uniprot/Q4I5U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Nucleus|||Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). http://togogenome.org/gene/229533:FGSG_01354 ^@ http://purl.uniprot.org/uniprot/I1RCN3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/229533:FGSG_00183 ^@ http://purl.uniprot.org/uniprot/I1R9N2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04038 ^@ http://purl.uniprot.org/uniprot/I1RJL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/229533:FGSG_00493 ^@ http://purl.uniprot.org/uniprot/I1RAG5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_03177 ^@ http://purl.uniprot.org/uniprot/I1RHD1 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/229533:FGSG_07131 ^@ http://purl.uniprot.org/uniprot/I1RSK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03390 ^@ http://purl.uniprot.org/uniprot/I1RHX4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01623 ^@ http://purl.uniprot.org/uniprot/I1RDC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.|||Nucleus http://togogenome.org/gene/229533:FGSG_10066 ^@ http://purl.uniprot.org/uniprot/I1S050 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_08070 ^@ http://purl.uniprot.org/uniprot/I1RV10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_00049 ^@ http://purl.uniprot.org/uniprot/I1R9B6 ^@ Function|||Similarity ^@ Aminotransferase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).|||Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_09904 ^@ http://purl.uniprot.org/uniprot/A0A1I9F3T8|||http://purl.uniprot.org/uniprot/Q4HYQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity).|||Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression. http://togogenome.org/gene/229533:FGSG_02519 ^@ http://purl.uniprot.org/uniprot/I1RFN8 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2) (By similarity).|||Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies (By similarity). Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles (By similarity). The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Prevacuolar compartment membrane|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Reduces strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||multivesicular body membrane http://togogenome.org/gene/229533:FGSG_01187 ^@ http://purl.uniprot.org/uniprot/I1RC84 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/229533:FGSG_09686 ^@ http://purl.uniprot.org/uniprot/I1RZ60 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/229533:FGSG_02706 ^@ http://purl.uniprot.org/uniprot/I1RG57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Nucleus|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. http://togogenome.org/gene/229533:FGSG_09601 ^@ http://purl.uniprot.org/uniprot/A0A1I9FNL8|||http://purl.uniprot.org/uniprot/Q4HZK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||Cytoplasm|||Involved in nuclear export, actin cytoskeleton organization and vesicular transport.|||Nucleus http://togogenome.org/gene/229533:FGSG_05106 ^@ http://purl.uniprot.org/uniprot/I1RMB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/229533:FGSG_10288 ^@ http://purl.uniprot.org/uniprot/I1S0Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00813 ^@ http://purl.uniprot.org/uniprot/I1RBA2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01353 ^@ http://purl.uniprot.org/uniprot/I1RCN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_06255 ^@ http://purl.uniprot.org/uniprot/I1RQB4 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/229533:FGSG_00298 ^@ http://purl.uniprot.org/uniprot/I1R9Y2 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/229533:FGSG_03846 ^@ http://purl.uniprot.org/uniprot/I1RJ45 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/229533:FGSG_01069 ^@ http://purl.uniprot.org/uniprot/I1RBX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_06511 ^@ http://purl.uniprot.org/uniprot/I1RR08 ^@ Similarity ^@ Belongs to the peptidase C2 family. PalB/RIM13 subfamily. http://togogenome.org/gene/229533:FGSG_07154 ^@ http://purl.uniprot.org/uniprot/I1RSM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/229533:FGSG_09138 ^@ http://purl.uniprot.org/uniprot/I1RXR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_03956 ^@ http://purl.uniprot.org/uniprot/I1RJE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03713 ^@ http://purl.uniprot.org/uniprot/I1RIR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 3 family.|||Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.|||Secreted http://togogenome.org/gene/229533:FGSG_06183 ^@ http://purl.uniprot.org/uniprot/I1RQ47 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.|||Belongs to the peptidase S16 family.|||Homohexamer or homoheptamer. Organized in a ring with a central cavity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_05537 ^@ http://purl.uniprot.org/uniprot/I1RNG1 ^@ Function|||Similarity ^@ Belongs to the CDC123 family.|||Regulates the cell cycle in a nutrient dependent manner. http://togogenome.org/gene/229533:FGSG_05907 ^@ http://purl.uniprot.org/uniprot/I1RPE0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/229533:FGSG_10246 ^@ http://purl.uniprot.org/uniprot/I1S0L4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/229533:FGSG_00902 ^@ http://purl.uniprot.org/uniprot/V6QWX8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.|||Nucleus http://togogenome.org/gene/229533:FGSG_05977 ^@ http://purl.uniprot.org/uniprot/I1RPK4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_06122 ^@ http://purl.uniprot.org/uniprot/I1RPZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/229533:FGSG_08187 ^@ http://purl.uniprot.org/uniprot/I1RVC0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_02118 ^@ http://purl.uniprot.org/uniprot/I1REM6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_11698 ^@ http://purl.uniprot.org/uniprot/I1S4D1 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/229533:FGSG_09598 ^@ http://purl.uniprot.org/uniprot/I1RYY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M67A family. CSN6 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_07467 ^@ http://purl.uniprot.org/uniprot/I1RTG3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/229533:FGSG_00325 ^@ http://purl.uniprot.org/uniprot/I1RA08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD1 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/229533:FGSG_13347 ^@ http://purl.uniprot.org/uniprot/I1S917 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02305 ^@ http://purl.uniprot.org/uniprot/I1RF39 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/229533:FGSG_07336 ^@ http://purl.uniprot.org/uniprot/I1RT42 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/229533:FGSG_11672 ^@ http://purl.uniprot.org/uniprot/I1S4A5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08413 ^@ http://purl.uniprot.org/uniprot/I1RVW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||This enzyme is required for electron transfer from NADP to cytochrome P450. http://togogenome.org/gene/229533:FGSG_09653 ^@ http://purl.uniprot.org/uniprot/I1RZ34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the ALG3 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_00310 ^@ http://purl.uniprot.org/uniprot/I1R9Z3 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/229533:FGSG_09612 ^@ http://purl.uniprot.org/uniprot/A0A1I9FNK6|||http://purl.uniprot.org/uniprot/P0C431 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Activated by threonine and tyrosine phosphorylation.|||Activated by tyrosine and threonine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.|||Cytoplasm|||Dually phosphorylated on Thr-171 and Tyr-173, which activates the enzyme.|||Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).|||Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes.|||Nucleus|||The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. http://togogenome.org/gene/229533:FGSG_01662 ^@ http://purl.uniprot.org/uniprot/I1RDG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01927 ^@ http://purl.uniprot.org/uniprot/I1RE53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02632 ^@ http://purl.uniprot.org/uniprot/I1RFY7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_07549 ^@ http://purl.uniprot.org/uniprot/I1RTN6 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/229533:FGSG_13445 ^@ http://purl.uniprot.org/uniprot/I1S9B5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09774 ^@ http://purl.uniprot.org/uniprot/A0A1I9FS72|||http://purl.uniprot.org/uniprot/Q4HZ34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins.|||Cytoplasm|||Heterotetramer of 2 NBP35 and 2 CFD1 chains. http://togogenome.org/gene/229533:FGSG_05321 ^@ http://purl.uniprot.org/uniprot/I1RMW8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. http://togogenome.org/gene/229533:FGSG_10944 ^@ http://purl.uniprot.org/uniprot/I1S2F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_05727 ^@ http://purl.uniprot.org/uniprot/I1RNY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/229533:FGSG_09918 ^@ http://purl.uniprot.org/uniprot/I1RZR5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10187 ^@ http://purl.uniprot.org/uniprot/I1S0G1 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/229533:FGSG_07213 ^@ http://purl.uniprot.org/uniprot/I1RST0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Regulatory subunit of the dolichol-phosphate mannose (DPM) synthase complex; essential for the ER localization. http://togogenome.org/gene/229533:FGSG_01653 ^@ http://purl.uniprot.org/uniprot/I1RDF7 ^@ Similarity|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Component of the mitochondrial small ribosomal subunit. http://togogenome.org/gene/229533:FGSG_10351 ^@ http://purl.uniprot.org/uniprot/I1S0W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_09446 ^@ http://purl.uniprot.org/uniprot/I1RYJ2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/229533:FGSG_03930 ^@ http://purl.uniprot.org/uniprot/I1RJB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11022 ^@ http://purl.uniprot.org/uniprot/I1S2M3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00330 ^@ http://purl.uniprot.org/uniprot/I1RA13 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_10730 ^@ http://purl.uniprot.org/uniprot/I1S1V7 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/229533:FGSG_05896 ^@ http://purl.uniprot.org/uniprot/A0A1I9FRJ6|||http://purl.uniprot.org/uniprot/Q4IA62 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family.|||Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.|||Membrane|||Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).|||The DHHC domain is required for palmitoyltransferase activity.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_05190 ^@ http://purl.uniprot.org/uniprot/I1RMK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09984 ^@ http://purl.uniprot.org/uniprot/V6RQW4 ^@ Function|||Similarity ^@ Belongs to the HisA/HisF family.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.|||In the C-terminal section; belongs to the HisA/HisF family. http://togogenome.org/gene/229533:FGSG_04214 ^@ http://purl.uniprot.org/uniprot/I1RK26 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_00941 ^@ http://purl.uniprot.org/uniprot/I1RBL4 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/229533:FGSG_03892 ^@ http://purl.uniprot.org/uniprot/I1RJ84 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01446 ^@ http://purl.uniprot.org/uniprot/I1RCW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_07129 ^@ http://purl.uniprot.org/uniprot/I1RSK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06788 ^@ http://purl.uniprot.org/uniprot/I1RRQ3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_07227 ^@ http://purl.uniprot.org/uniprot/I1RSU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_04284 ^@ http://purl.uniprot.org/uniprot/I1RK90 ^@ Similarity|||Subunit ^@ Associated with the spliceosome.|||Belongs to the crooked-neck family. http://togogenome.org/gene/229533:FGSG_01356 ^@ http://purl.uniprot.org/uniprot/A0A1I9EYL7|||http://purl.uniprot.org/uniprot/Q4IN52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/229533:FGSG_00609 ^@ http://purl.uniprot.org/uniprot/I1RAS4 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/229533:FGSG_05998 ^@ http://purl.uniprot.org/uniprot/I1RPM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01729 ^@ http://purl.uniprot.org/uniprot/I1RDM0 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/229533:FGSG_08972 ^@ http://purl.uniprot.org/uniprot/I1RXB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06243 ^@ http://purl.uniprot.org/uniprot/I1RQA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/229533:FGSG_08498 ^@ http://purl.uniprot.org/uniprot/I1RW43 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_10180 ^@ http://purl.uniprot.org/uniprot/V6RXW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/229533:FGSG_05393 ^@ http://purl.uniprot.org/uniprot/I1RN31 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_03786 ^@ http://purl.uniprot.org/uniprot/I1RIY9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04308 ^@ http://purl.uniprot.org/uniprot/I1RKB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06006 ^@ http://purl.uniprot.org/uniprot/I1RPN1 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/229533:FGSG_05889 ^@ http://purl.uniprot.org/uniprot/I1RPC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00718 ^@ http://purl.uniprot.org/uniprot/V6QVH2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_04453 ^@ http://purl.uniprot.org/uniprot/A0A1I9FGK4|||http://purl.uniprot.org/uniprot/Q4IEA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/229533:FGSG_09600 ^@ http://purl.uniprot.org/uniprot/I1RYY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the VPS17 family.|||Component of the retromer complex.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/229533:FGSG_08810 ^@ http://purl.uniprot.org/uniprot/I1RWX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04319 ^@ http://purl.uniprot.org/uniprot/I1RKB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02461 ^@ http://purl.uniprot.org/uniprot/I1RFI4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_05309 ^@ http://purl.uniprot.org/uniprot/I1RMV9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13552 ^@ http://purl.uniprot.org/uniprot/I1S9M1 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/229533:FGSG_07401 ^@ http://purl.uniprot.org/uniprot/I1RTA0 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_01798 ^@ http://purl.uniprot.org/uniprot/I1RDT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06751 ^@ http://purl.uniprot.org/uniprot/I1RRM1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_08920 ^@ http://purl.uniprot.org/uniprot/I1RX70 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/229533:FGSG_07685 ^@ http://purl.uniprot.org/uniprot/I1RU11 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_10212 ^@ http://purl.uniprot.org/uniprot/I1S0I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cerato-platanin family.|||Secreted http://togogenome.org/gene/229533:FGSG_13870 ^@ http://purl.uniprot.org/uniprot/I1SAI9 ^@ Similarity ^@ Belongs to the asaB hydroxylase/desaturase family. http://togogenome.org/gene/229533:FGSG_01967 ^@ http://purl.uniprot.org/uniprot/I1RE86 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/229533:FGSG_06657 ^@ http://purl.uniprot.org/uniprot/I1RRD8 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_07237 ^@ http://purl.uniprot.org/uniprot/I1RSV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/229533:FGSG_05245 ^@ http://purl.uniprot.org/uniprot/I1RMQ1 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_07405 ^@ http://purl.uniprot.org/uniprot/A0A1I9FHS6|||http://purl.uniprot.org/uniprot/Q4I5V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enhancer of polycomb family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M.|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_00501 ^@ http://purl.uniprot.org/uniprot/A0A1I9EVR0|||http://purl.uniprot.org/uniprot/Q4IQK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Cytoplasm|||Monomer.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. http://togogenome.org/gene/229533:FGSG_10855 ^@ http://purl.uniprot.org/uniprot/I1S269 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_01854 ^@ http://purl.uniprot.org/uniprot/I1RDY5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_11556 ^@ http://purl.uniprot.org/uniprot/I1S404 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00836 ^@ http://purl.uniprot.org/uniprot/I1RBC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YME2 family.|||Membrane|||Mitochondrion inner membrane|||Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA. http://togogenome.org/gene/229533:FGSG_02639 ^@ http://purl.uniprot.org/uniprot/I1RFZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAD2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08841 ^@ http://purl.uniprot.org/uniprot/I1RX00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02208 ^@ http://purl.uniprot.org/uniprot/I1REV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02320 ^@ http://purl.uniprot.org/uniprot/I1RF54 ^@ Disruption Phenotype|||Function|||Induction|||Subcellular Location Annotation ^@ Expression correlates with aurofusarin production and is restricted to vegetative mycelia (PubMed:16461721). Expression is negatively regulated by the MAPK-mediated osmotic stress-signaling pathway (PubMed:17897620).|||Leads to an albinos phenotype (PubMed:16879655). Inactivates the expression of the aurofusarin biosynthetic gene cluster (PubMed:16879655, PubMed:16461721).|||Nucleus|||Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15809006, PubMed:16879655, PubMed:16461721). http://togogenome.org/gene/229533:FGSG_06619 ^@ http://purl.uniprot.org/uniprot/V6REA4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09385 ^@ http://purl.uniprot.org/uniprot/A0A1I9FLI5|||http://purl.uniprot.org/uniprot/Q4I073 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity).|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity.|||Membrane http://togogenome.org/gene/229533:FGSG_05671 ^@ http://purl.uniprot.org/uniprot/I1RNT2 ^@ Similarity ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family. http://togogenome.org/gene/229533:FGSG_07610 ^@ http://purl.uniprot.org/uniprot/I1RTU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04899 ^@ http://purl.uniprot.org/uniprot/I1RLT0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08619 ^@ http://purl.uniprot.org/uniprot/I1RWF3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/229533:FGSG_03540 ^@ http://purl.uniprot.org/uniprot/I1RIA9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_12584 ^@ http://purl.uniprot.org/uniprot/I1S6W1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02099 ^@ http://purl.uniprot.org/uniprot/I1REK8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/229533:FGSG_06800 ^@ http://purl.uniprot.org/uniprot/I1RRR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/229533:FGSG_03769 ^@ http://purl.uniprot.org/uniprot/I1RIX2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/229533:FGSG_12182 ^@ http://purl.uniprot.org/uniprot/I1S5R1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/229533:FGSG_09981 ^@ http://purl.uniprot.org/uniprot/I1RZX5 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_13099 ^@ http://purl.uniprot.org/uniprot/I1S8C1 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02532 ^@ http://purl.uniprot.org/uniprot/I1RFP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_08129 ^@ http://purl.uniprot.org/uniprot/I1RV66 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/229533:FGSG_08908 ^@ http://purl.uniprot.org/uniprot/I1RX58 ^@ Similarity ^@ Belongs to the peptidase C59 family. http://togogenome.org/gene/229533:FGSG_08139 ^@ http://purl.uniprot.org/uniprot/I1RV75 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_10991 ^@ http://purl.uniprot.org/uniprot/I1S2J5 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the cytochrome P450 family.|||Cytochrome P450 monooxygenase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable).|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars. http://togogenome.org/gene/229533:FGSG_05303 ^@ http://purl.uniprot.org/uniprot/I1RMV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11326 ^@ http://purl.uniprot.org/uniprot/V6RUY9 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 15 family. http://togogenome.org/gene/229533:FGSG_03795 ^@ http://purl.uniprot.org/uniprot/I1RIZ7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_10189 ^@ http://purl.uniprot.org/uniprot/I1S0G3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_04321 ^@ http://purl.uniprot.org/uniprot/I1RKC1 ^@ Similarity ^@ Belongs to the VEFS (VRN2-EMF2-FIS2-SU(Z)12) family. http://togogenome.org/gene/229533:FGSG_02072 ^@ http://purl.uniprot.org/uniprot/I1REI3 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/229533:FGSG_04720 ^@ http://purl.uniprot.org/uniprot/I1RLC8 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_02329 ^@ http://purl.uniprot.org/uniprot/I1RF63 ^@ Disruption Phenotype|||Function|||Induction|||Subcellular Location Annotation|||Subunit ^@ Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).|||Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:21296881).|||Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).|||Part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||Secreted|||extracellular space http://togogenome.org/gene/229533:FGSG_09873 ^@ http://purl.uniprot.org/uniprot/I1RZM4 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/229533:FGSG_07528 ^@ http://purl.uniprot.org/uniprot/I1RTL7 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/229533:FGSG_10613 ^@ http://purl.uniprot.org/uniprot/I1S1K6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08560 ^@ http://purl.uniprot.org/uniprot/A0A1I9F8I2|||http://purl.uniprot.org/uniprot/Q4I2J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-alpha family.|||Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity). http://togogenome.org/gene/229533:FGSG_07639 ^@ http://purl.uniprot.org/uniprot/I1RTX1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_05974 ^@ http://purl.uniprot.org/uniprot/I1RPK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_08892 ^@ http://purl.uniprot.org/uniprot/I1RX43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MATALPHA1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10986 ^@ http://purl.uniprot.org/uniprot/I1S2J1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_02520 ^@ http://purl.uniprot.org/uniprot/I1RFN9 ^@ Similarity ^@ Belongs to the VPS72/YL1 family. http://togogenome.org/gene/229533:FGSG_05839 ^@ http://purl.uniprot.org/uniprot/I1RP83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11526 ^@ http://purl.uniprot.org/uniprot/I1S3X6 ^@ Similarity ^@ Belongs to the glycerate kinase type-1 family. http://togogenome.org/gene/229533:FGSG_04470 ^@ http://purl.uniprot.org/uniprot/I1RKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/229533:FGSG_09313 ^@ http://purl.uniprot.org/uniprot/I1RY75 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_01802 ^@ http://purl.uniprot.org/uniprot/I1RDT6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_02598 ^@ http://purl.uniprot.org/uniprot/I1RFV7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.|||Membrane http://togogenome.org/gene/229533:FGSG_00265 ^@ http://purl.uniprot.org/uniprot/I1R9V3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/229533:FGSG_06035 ^@ http://purl.uniprot.org/uniprot/I1RPQ7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_02724 ^@ http://purl.uniprot.org/uniprot/A0A1I9F341|||http://purl.uniprot.org/uniprot/Q4IJ84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Cytoplasm|||Nucleus|||Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). http://togogenome.org/gene/229533:FGSG_07473 ^@ http://purl.uniprot.org/uniprot/I1RTG9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/229533:FGSG_04141 ^@ http://purl.uniprot.org/uniprot/I1RJV8 ^@ Function|||Similarity ^@ Acts in DNA repair and mutagenesis. Involved in promoting resistance to ionizing radiation and UV light, as well as regulating cell cycle progression after irradiation.|||Belongs to the rad9 family. http://togogenome.org/gene/229533:FGSG_01162 ^@ http://purl.uniprot.org/uniprot/I1RC59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00864 ^@ http://purl.uniprot.org/uniprot/V6QV38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_04527 ^@ http://purl.uniprot.org/uniprot/I1RKV6 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/229533:FGSG_09988 ^@ http://purl.uniprot.org/uniprot/I1RZX9 ^@ Similarity|||Subunit ^@ Belongs to the G-alpha family. G(q) subfamily.|||G proteins are composed of 3 units; alpha, beta and gamma. The alpha chain contains the guanine nucleotide binding site. http://togogenome.org/gene/229533:FGSG_10881 ^@ http://purl.uniprot.org/uniprot/A0A1C3YK94|||http://purl.uniprot.org/uniprot/Q4HVX7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/229533:FGSG_05001 ^@ http://purl.uniprot.org/uniprot/V6R8C4 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/229533:FGSG_09382 ^@ http://purl.uniprot.org/uniprot/I1RYD6 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_04289 ^@ http://purl.uniprot.org/uniprot/V6R3L4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/229533:FGSG_06100 ^@ http://purl.uniprot.org/uniprot/I1RPW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_04028 ^@ http://purl.uniprot.org/uniprot/A0A1I9FF33|||http://purl.uniprot.org/uniprot/Q4IFI0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||Interacts with the SSU processome.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_06204 ^@ http://purl.uniprot.org/uniprot/V6RCZ8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/229533:FGSG_01186 ^@ http://purl.uniprot.org/uniprot/I1RC83 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_03742 ^@ http://purl.uniprot.org/uniprot/I1RIU7 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_01932 ^@ http://purl.uniprot.org/uniprot/I1RE58 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/229533:FGSG_02717 ^@ http://purl.uniprot.org/uniprot/I1RG66 ^@ Similarity ^@ Belongs to the IlvD/Edd family. http://togogenome.org/gene/229533:FGSG_05065 ^@ http://purl.uniprot.org/uniprot/I1RM82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. http://togogenome.org/gene/229533:FGSG_05382 ^@ http://purl.uniprot.org/uniprot/I1RN21 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09847 ^@ http://purl.uniprot.org/uniprot/I1RZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS1 family.|||spindle http://togogenome.org/gene/229533:FGSG_07948 ^@ http://purl.uniprot.org/uniprot/I1RUP8 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/229533:FGSG_00700 ^@ http://purl.uniprot.org/uniprot/A0A1I9EWA6|||http://purl.uniprot.org/uniprot/Q4IQ08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/229533:FGSG_03591 ^@ http://purl.uniprot.org/uniprot/I1RIF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Secreted http://togogenome.org/gene/229533:FGSG_08587 ^@ http://purl.uniprot.org/uniprot/I1RWC3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class III subfamily. http://togogenome.org/gene/229533:FGSG_00028 ^@ http://purl.uniprot.org/uniprot/I1R999 ^@ Function|||Similarity ^@ Belongs to the peptidase M43B family.|||Secreted metalloproteinase that allows assimilation of proteinaceous substrates. http://togogenome.org/gene/229533:FGSG_11967 ^@ http://purl.uniprot.org/uniprot/I1S549 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_00343 ^@ http://purl.uniprot.org/uniprot/I1RA25 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/229533:FGSG_02658 ^@ http://purl.uniprot.org/uniprot/I1RG10 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 45 (cellulase K) family. http://togogenome.org/gene/229533:FGSG_11049 ^@ http://purl.uniprot.org/uniprot/I1S2P9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate esterase 1 (CE1) family.|||Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.|||Secreted http://togogenome.org/gene/229533:FGSG_03249 ^@ http://purl.uniprot.org/uniprot/I1RHJ2 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05541 ^@ http://purl.uniprot.org/uniprot/I1RNG4 ^@ Function ^@ Trifunctional enzyme bearing the Gln amidotransferase (GATase) domain of anthranilate synthase, indole-glycerolphosphate synthase, and phosphoribosylanthranilate isomerase activities. http://togogenome.org/gene/229533:FGSG_11721 ^@ http://purl.uniprot.org/uniprot/I1S4F4 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/229533:FGSG_06156 ^@ http://purl.uniprot.org/uniprot/I1RQ23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/229533:FGSG_13008 ^@ http://purl.uniprot.org/uniprot/I1S832 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12141 ^@ http://purl.uniprot.org/uniprot/I1S5M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10805 ^@ http://purl.uniprot.org/uniprot/I1S224 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_05469 ^@ http://purl.uniprot.org/uniprot/I1RNA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/229533:FGSG_00911 ^@ http://purl.uniprot.org/uniprot/I1RBI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/229533:FGSG_04274 ^@ http://purl.uniprot.org/uniprot/I1RK80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_09834 ^@ http://purl.uniprot.org/uniprot/V6RPS5 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/229533:FGSG_06566 ^@ http://purl.uniprot.org/uniprot/V6RE46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_04291 ^@ http://purl.uniprot.org/uniprot/I1RK95 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/229533:FGSG_04590 ^@ http://purl.uniprot.org/uniprot/I1RL13 ^@ Biotechnology|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350).|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||Membrane http://togogenome.org/gene/229533:FGSG_06382 ^@ http://purl.uniprot.org/uniprot/I1RQN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09266 ^@ http://purl.uniprot.org/uniprot/I1RY35 ^@ Function|||Induction|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.|||Hydroxymethylglutaryl-CoA synthase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG13 condenses acetyl-CoA with acetoacetyl-CoA to form hydroxymethylglutaryl-CoA (HMG-CoA) (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable). http://togogenome.org/gene/229533:FGSG_01515 ^@ http://purl.uniprot.org/uniprot/I1RD28 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01509 ^@ http://purl.uniprot.org/uniprot/I1RD22 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/229533:FGSG_02847 ^@ http://purl.uniprot.org/uniprot/I1RGI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_03412 ^@ http://purl.uniprot.org/uniprot/I1RHZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02204 ^@ http://purl.uniprot.org/uniprot/I1REV1 ^@ Similarity ^@ Belongs to the peptidase S28 family. http://togogenome.org/gene/229533:FGSG_06017 ^@ http://purl.uniprot.org/uniprot/I1RPP1 ^@ Similarity ^@ Belongs to the Necrosis inducing protein (NPP1) family. http://togogenome.org/gene/229533:FGSG_10839 ^@ http://purl.uniprot.org/uniprot/I1S255 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06299 ^@ http://purl.uniprot.org/uniprot/I1RQF7 ^@ Similarity ^@ Belongs to the COG3 family. http://togogenome.org/gene/229533:FGSG_08783 ^@ http://purl.uniprot.org/uniprot/I1RWU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02794 ^@ http://purl.uniprot.org/uniprot/I1RGD5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/229533:FGSG_03971 ^@ http://purl.uniprot.org/uniprot/I1RJF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cerato-platanin family.|||Secreted http://togogenome.org/gene/229533:FGSG_11357 ^@ http://purl.uniprot.org/uniprot/I1S3H5 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. http://togogenome.org/gene/229533:FGSG_02998 ^@ http://purl.uniprot.org/uniprot/I1RGW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02767 ^@ http://purl.uniprot.org/uniprot/I1RGA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06273 ^@ http://purl.uniprot.org/uniprot/I1RQD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02105 ^@ http://purl.uniprot.org/uniprot/I1REL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Membrane http://togogenome.org/gene/229533:FGSG_13483 ^@ http://purl.uniprot.org/uniprot/I1S9F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_01370 ^@ http://purl.uniprot.org/uniprot/I1RCP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05368 ^@ http://purl.uniprot.org/uniprot/I1RN10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12725 ^@ http://purl.uniprot.org/uniprot/I1S7A2 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/229533:FGSG_00189 ^@ http://purl.uniprot.org/uniprot/I1R9N7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/229533:FGSG_00107 ^@ http://purl.uniprot.org/uniprot/I1R9G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00026 ^@ http://purl.uniprot.org/uniprot/I1R997 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07980 ^@ http://purl.uniprot.org/uniprot/I1RUS6 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/229533:FGSG_12398 ^@ http://purl.uniprot.org/uniprot/I1S6C7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07495 ^@ http://purl.uniprot.org/uniprot/I1RTI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06222 ^@ http://purl.uniprot.org/uniprot/I1RQ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01464 ^@ http://purl.uniprot.org/uniprot/I1RCY0 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/229533:FGSG_10606 ^@ http://purl.uniprot.org/uniprot/A0A1I9F616|||http://purl.uniprot.org/uniprot/Q4HWQ2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peroxidase family. Cytochrome c peroxidase subfamily.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/229533:FGSG_12355 ^@ http://purl.uniprot.org/uniprot/I1S684 ^@ Similarity ^@ In the 2nd section; belongs to the type-I 3-dehydroquinase family.|||In the N-terminal section; belongs to the shikimate kinase family. http://togogenome.org/gene/229533:FGSG_02354 ^@ http://purl.uniprot.org/uniprot/I1RF87 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_01324 ^@ http://purl.uniprot.org/uniprot/I1RCK5 ^@ Similarity ^@ Belongs to the VPS37 family. http://togogenome.org/gene/229533:FGSG_04300 ^@ http://purl.uniprot.org/uniprot/I1RKA3 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/229533:FGSG_02220 ^@ http://purl.uniprot.org/uniprot/V6QZ48 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09713 ^@ http://purl.uniprot.org/uniprot/A0A1I9FS24|||http://purl.uniprot.org/uniprot/Q4HZ95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10307 ^@ http://purl.uniprot.org/uniprot/I1S0S0 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/229533:FGSG_06056 ^@ http://purl.uniprot.org/uniprot/I1RPS7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_06342 ^@ http://purl.uniprot.org/uniprot/I1RQJ7 ^@ Function|||Similarity ^@ Belongs to the 3-oxoacid CoA-transferase family.|||Key enzyme for ketone body catabolism. Transfers the CoA moiety from succinate to acetoacetate. Formation of the enzyme-CoA intermediate proceeds via an unstable anhydride species formed between the carboxylate groups of the enzyme and substrate. http://togogenome.org/gene/229533:FGSG_05023 ^@ http://purl.uniprot.org/uniprot/I1RM44 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09616 ^@ http://purl.uniprot.org/uniprot/I1RYZ9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/229533:FGSG_08623 ^@ http://purl.uniprot.org/uniprot/I1RWF6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_06921 ^@ http://purl.uniprot.org/uniprot/I1RS17 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/229533:FGSG_06104 ^@ http://purl.uniprot.org/uniprot/I1RPX2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05184 ^@ http://purl.uniprot.org/uniprot/I1RMJ4 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_07146 ^@ http://purl.uniprot.org/uniprot/I1RSM2 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/229533:FGSG_10379 ^@ http://purl.uniprot.org/uniprot/I1S0Y7 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/229533:FGSG_13433 ^@ http://purl.uniprot.org/uniprot/I1S9A3 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_01425 ^@ http://purl.uniprot.org/uniprot/I1RCU4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. http://togogenome.org/gene/229533:FGSG_04619 ^@ http://purl.uniprot.org/uniprot/I1RL39 ^@ Similarity ^@ Belongs to the RdRP family. http://togogenome.org/gene/229533:FGSG_02474 ^@ http://purl.uniprot.org/uniprot/I1RFJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS4 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11028 ^@ http://purl.uniprot.org/uniprot/I1S2M9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11115 ^@ http://purl.uniprot.org/uniprot/I1S2W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03145 ^@ http://purl.uniprot.org/uniprot/I1RHA0 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_09157 ^@ http://purl.uniprot.org/uniprot/I1RXT2 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sorting nexin family.|||Cytoplasm|||Endosome membrane|||Forms a complex with ATG20 and ATG17 (By similarity).|||Membrane|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).|||Sorting nexin involved in the separation or division of vacuoles throughout the entire life cycle of the cells (By similarity). Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), mitophagy, and pexophagy (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures. http://togogenome.org/gene/229533:FGSG_02368 ^@ http://purl.uniprot.org/uniprot/I1RF99 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01573 ^@ http://purl.uniprot.org/uniprot/I1RD81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_09580 ^@ http://purl.uniprot.org/uniprot/I1RYW9 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/229533:FGSG_01593 ^@ http://purl.uniprot.org/uniprot/I1RDA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01513 ^@ http://purl.uniprot.org/uniprot/I1RD26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anthrone oxygenase family.|||Membrane http://togogenome.org/gene/229533:FGSG_00752 ^@ http://purl.uniprot.org/uniprot/I1RB47 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09819 ^@ http://purl.uniprot.org/uniprot/I1RZH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00349 ^@ http://purl.uniprot.org/uniprot/A0A1I9EV33|||http://purl.uniprot.org/uniprot/Q4IR09 ^@ Function|||Subcellular Location Annotation ^@ Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_01116 ^@ http://purl.uniprot.org/uniprot/I1RC15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01279 ^@ http://purl.uniprot.org/uniprot/I1RCG5 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. http://togogenome.org/gene/229533:FGSG_09978 ^@ http://purl.uniprot.org/uniprot/A0A1I9F447|||http://purl.uniprot.org/uniprot/Q4HYI0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the 7-subunit TFIIH core complex.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/229533:FGSG_12390 ^@ http://purl.uniprot.org/uniprot/I1S6B9 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_07450 ^@ http://purl.uniprot.org/uniprot/I1RTE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/229533:FGSG_05156 ^@ http://purl.uniprot.org/uniprot/I1RMG6 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. http://togogenome.org/gene/229533:FGSG_01418 ^@ http://purl.uniprot.org/uniprot/I1RCT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10025 ^@ http://purl.uniprot.org/uniprot/V6RRR4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05433 ^@ http://purl.uniprot.org/uniprot/I1RN67 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/229533:FGSG_04782 ^@ http://purl.uniprot.org/uniprot/I1RLI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01933 ^@ http://purl.uniprot.org/uniprot/I1RE59 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_09675 ^@ http://purl.uniprot.org/uniprot/I1RZ50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_02386 ^@ http://purl.uniprot.org/uniprot/I1RFB7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 3 family.|||Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.|||Secreted http://togogenome.org/gene/229533:FGSG_05527 ^@ http://purl.uniprot.org/uniprot/I1RNF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01119 ^@ http://purl.uniprot.org/uniprot/I1RC18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06306 ^@ http://purl.uniprot.org/uniprot/I1RQG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/229533:FGSG_12726 ^@ http://purl.uniprot.org/uniprot/I1S7A3 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/229533:FGSG_06867 ^@ http://purl.uniprot.org/uniprot/I1RRW7 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/229533:FGSG_05335 ^@ http://purl.uniprot.org/uniprot/I1RMY1 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/229533:FGSG_12042 ^@ http://purl.uniprot.org/uniprot/I1S5C4 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/229533:FGSG_10043 ^@ http://purl.uniprot.org/uniprot/I1S029 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/229533:FGSG_06463 ^@ http://purl.uniprot.org/uniprot/I1RQW2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 51 family. http://togogenome.org/gene/229533:FGSG_05448 ^@ http://purl.uniprot.org/uniprot/I1RN82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05565 ^@ http://purl.uniprot.org/uniprot/I1RNI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_11215 ^@ http://purl.uniprot.org/uniprot/I1S350 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_07568 ^@ http://purl.uniprot.org/uniprot/I1RTQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13166 ^@ http://purl.uniprot.org/uniprot/I1S8I8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_03127 ^@ http://purl.uniprot.org/uniprot/I1RH82 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/229533:FGSG_12737 ^@ http://purl.uniprot.org/uniprot/I1S7B4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_00895 ^@ http://purl.uniprot.org/uniprot/I1RBH2 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_08066 ^@ http://purl.uniprot.org/uniprot/I1RV06 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_04864 ^@ http://purl.uniprot.org/uniprot/I1RLQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 3 family.|||Pectinolytic enzyme consist of four classes of enzymes: pectin lyase, polygalacturonase, pectin methylesterase and rhamnogalacturonase. Among pectinolytic enzymes, pectin lyase is the most important in depolymerization of pectin, since it cleaves internal glycosidic bonds of highly methylated pectins. Favors pectate, the anion, over pectin, the methyl ester.|||Secreted http://togogenome.org/gene/229533:FGSG_08675 ^@ http://purl.uniprot.org/uniprot/Q4I283 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-beta family.|||Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity). http://togogenome.org/gene/229533:FGSG_00666 ^@ http://purl.uniprot.org/uniprot/I1RAX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/229533:FGSG_01241 ^@ http://purl.uniprot.org/uniprot/I1RCD4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/229533:FGSG_04243 ^@ http://purl.uniprot.org/uniprot/I1RK55 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/229533:FGSG_08710 ^@ http://purl.uniprot.org/uniprot/I1RWN4 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_02267 ^@ http://purl.uniprot.org/uniprot/I1RF05 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_03133 ^@ http://purl.uniprot.org/uniprot/I1RH88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04087 ^@ http://purl.uniprot.org/uniprot/I1RJQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Membrane http://togogenome.org/gene/229533:FGSG_03264 ^@ http://purl.uniprot.org/uniprot/I1RHK6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_07962 ^@ http://purl.uniprot.org/uniprot/I1RUR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09401 ^@ http://purl.uniprot.org/uniprot/I1RYF2 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_02588 ^@ http://purl.uniprot.org/uniprot/I1RFU8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/229533:FGSG_11493 ^@ http://purl.uniprot.org/uniprot/I1S3U5 ^@ Similarity ^@ Belongs to the Necrosis inducing protein (NPP1) family. http://togogenome.org/gene/229533:FGSG_06649 ^@ http://purl.uniprot.org/uniprot/I1RRD0 ^@ Similarity ^@ Belongs to the SMP-30/CGR1 family. http://togogenome.org/gene/229533:FGSG_11683 ^@ http://purl.uniprot.org/uniprot/I1S4B6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10561 ^@ http://purl.uniprot.org/uniprot/I1S1G0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/229533:FGSG_05646 ^@ http://purl.uniprot.org/uniprot/I1RNR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10152 ^@ http://purl.uniprot.org/uniprot/I1S0C9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06955 ^@ http://purl.uniprot.org/uniprot/I1RS47 ^@ Similarity ^@ Belongs to the peptidase M24 family. http://togogenome.org/gene/229533:FGSG_05329 ^@ http://purl.uniprot.org/uniprot/Q4IBS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRO1 family.|||Cytoplasm|||Endosome|||Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. http://togogenome.org/gene/229533:FGSG_07107 ^@ http://purl.uniprot.org/uniprot/I1RSI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/229533:FGSG_12671 ^@ http://purl.uniprot.org/uniprot/I1S748 ^@ Function|||Similarity ^@ Belongs to the peptidase M54 family.|||Probable zinc metalloprotease. http://togogenome.org/gene/229533:FGSG_07940 ^@ http://purl.uniprot.org/uniprot/I1RUP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/229533:FGSG_07970 ^@ http://purl.uniprot.org/uniprot/I1RUR8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07524 ^@ http://purl.uniprot.org/uniprot/A0A1I9FH61|||http://purl.uniprot.org/uniprot/Q4I5I4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT5 family.|||Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).|||Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II.|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. http://togogenome.org/gene/229533:FGSG_00218 ^@ http://purl.uniprot.org/uniprot/I1R9R3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family. http://togogenome.org/gene/229533:FGSG_05611 ^@ http://purl.uniprot.org/uniprot/I1RNM8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_07692 ^@ http://purl.uniprot.org/uniprot/I1RU18 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. http://togogenome.org/gene/229533:FGSG_00261 ^@ http://purl.uniprot.org/uniprot/I1R9U9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_10655 ^@ http://purl.uniprot.org/uniprot/I1S1P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07265 ^@ http://purl.uniprot.org/uniprot/I1RSX8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07125 ^@ http://purl.uniprot.org/uniprot/I1RSK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13661 ^@ http://purl.uniprot.org/uniprot/I1S9Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SQS1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_11597 ^@ http://purl.uniprot.org/uniprot/I1S439 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_02492 ^@ http://purl.uniprot.org/uniprot/I1RFL3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BMT2 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.|||nucleolus http://togogenome.org/gene/229533:FGSG_13829 ^@ http://purl.uniprot.org/uniprot/I1SAE8 ^@ Cofactor|||Similarity ^@ Belongs to the cysteine dioxygenase family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/229533:FGSG_01490 ^@ http://purl.uniprot.org/uniprot/I1RD03 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/229533:FGSG_07775 ^@ http://purl.uniprot.org/uniprot/I1RU91 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_11008 ^@ http://purl.uniprot.org/uniprot/I1S2L1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10226 ^@ http://purl.uniprot.org/uniprot/I1S0J7 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy (By similarity). Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine (By similarity). Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Homodimer (By similarity). Interacts with ATG8 through a thioester bond between Cys-550 and the C-terminal 'Gly-116' of ATG8 and with ATG12 through a thioester bond between Cys-550 and the C-terminal 'Gly-160' of ATG12 (By similarity). Interacts also with ATG3 (By similarity).|||Preautophagosomal structure|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||The C-terminal residues 650 to 689 are required for homodimerization, as well as the interactions with ATG3, ATG8 and ATG12; and the C-terminal 17 residues are required for the ATG8 lipidation (By similarity).|||The GxGxxG motif is important for the function, possibly through binding with ATP (By similarity). http://togogenome.org/gene/229533:FGSG_02986 ^@ http://purl.uniprot.org/uniprot/I1RGV6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04732 ^@ http://purl.uniprot.org/uniprot/I1RLD7 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_07253 ^@ http://purl.uniprot.org/uniprot/I1RSW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIMR family. LMBRD1 subfamily.|||Lysosome membrane|||Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. http://togogenome.org/gene/229533:FGSG_09631 ^@ http://purl.uniprot.org/uniprot/I1RZ13 ^@ Function ^@ Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER. http://togogenome.org/gene/229533:FGSG_06127 ^@ http://purl.uniprot.org/uniprot/I1RPZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. FDH subfamily.|||Catalyzes the NAD(+)-dependent oxidation of formate to carbon dioxide. Formate oxidation is the final step in the methanol oxidation pathway in methylotrophic microorganisms. Has a role in the detoxification of exogenous formate in non-methylotrophic organisms.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_05428 ^@ http://purl.uniprot.org/uniprot/I1RN63 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/229533:FGSG_01066 ^@ http://purl.uniprot.org/uniprot/I1RBX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03457 ^@ http://purl.uniprot.org/uniprot/I1RI35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_04936 ^@ http://purl.uniprot.org/uniprot/I1RLW6 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28A subfamily. http://togogenome.org/gene/229533:FGSG_07914 ^@ http://purl.uniprot.org/uniprot/I1RUL5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06087 ^@ http://purl.uniprot.org/uniprot/I1RPV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_11536 ^@ http://purl.uniprot.org/uniprot/I1S3Y5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_06931 ^@ http://purl.uniprot.org/uniprot/I1RS24 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/229533:FGSG_11636 ^@ http://purl.uniprot.org/uniprot/I1S471 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08840 ^@ http://purl.uniprot.org/uniprot/I1RWZ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/229533:FGSG_13310 ^@ http://purl.uniprot.org/uniprot/I1S8Y1 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/229533:FGSG_01614 ^@ http://purl.uniprot.org/uniprot/I1RDC0 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/229533:FGSG_10063 ^@ http://purl.uniprot.org/uniprot/I1S047 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08081 ^@ http://purl.uniprot.org/uniprot/I1RV21 ^@ Cofactor|||Function|||Induction|||Similarity ^@ 2-oxoglutarate-dependent dioxygenase; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).|||Belongs to the iron/ascorbate-dependent oxidoreductase family.|||Binds 1 Fe(2+) ion per subunit.|||Highly expressed under trichothecene-producing conditions. http://togogenome.org/gene/229533:FGSG_00669 ^@ http://purl.uniprot.org/uniprot/I1RAX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03391 ^@ http://purl.uniprot.org/uniprot/I1RHX5 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/229533:FGSG_08083 ^@ http://purl.uniprot.org/uniprot/I1RV23 ^@ Function|||Induction|||Similarity ^@ Belongs to the group II decarboxylase family.|||Glutamate decarboxylase-like protein; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).|||Highly expressed under trichothecene-producing conditions. http://togogenome.org/gene/229533:FGSG_11822 ^@ http://purl.uniprot.org/uniprot/I1S4Q4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_10299 ^@ http://purl.uniprot.org/uniprot/I1S0R2 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/229533:FGSG_03533 ^@ http://purl.uniprot.org/uniprot/I1RIA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08177 ^@ http://purl.uniprot.org/uniprot/V6RTD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01893 ^@ http://purl.uniprot.org/uniprot/I1RE20 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/229533:FGSG_05149 ^@ http://purl.uniprot.org/uniprot/I1RMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_01337 ^@ http://purl.uniprot.org/uniprot/V6QXG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the WD repeat PRL1/PRL2 family.|||Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.|||Nucleus http://togogenome.org/gene/229533:FGSG_05197 ^@ http://purl.uniprot.org/uniprot/I1RMK6 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/229533:FGSG_00940 ^@ http://purl.uniprot.org/uniprot/A0A1I9EX46|||http://purl.uniprot.org/uniprot/Q4IPB8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||Belongs to the cyclophilin-type PPIase family. PPIL3 subfamily.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_02605 ^@ http://purl.uniprot.org/uniprot/I1RFW4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_10979 ^@ http://purl.uniprot.org/uniprot/I1S2I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_00353 ^@ http://purl.uniprot.org/uniprot/I1RA32 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/229533:FGSG_02355 ^@ http://purl.uniprot.org/uniprot/I1RF88 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily. http://togogenome.org/gene/229533:FGSG_09757 ^@ http://purl.uniprot.org/uniprot/I1RZC4 ^@ Similarity ^@ Belongs to the thioesterase PaaI family. http://togogenome.org/gene/229533:FGSG_05775 ^@ http://purl.uniprot.org/uniprot/I1RP25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06404 ^@ http://purl.uniprot.org/uniprot/Q4I8Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.|||Cytoplasm|||Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.|||Nucleus http://togogenome.org/gene/229533:FGSG_05857 ^@ http://purl.uniprot.org/uniprot/I1RPA0 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/229533:FGSG_05806 ^@ http://purl.uniprot.org/uniprot/I1RP54 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_02839 ^@ http://purl.uniprot.org/uniprot/V6R882 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/229533:FGSG_02608 ^@ http://purl.uniprot.org/uniprot/I1RFW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05854 ^@ http://purl.uniprot.org/uniprot/I1RP97 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/229533:FGSG_02063 ^@ http://purl.uniprot.org/uniprot/I1REH4 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_00197 ^@ http://purl.uniprot.org/uniprot/I1R9P4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04757 ^@ http://purl.uniprot.org/uniprot/I1RLG0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_10676 ^@ http://purl.uniprot.org/uniprot/I1S1R1 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/229533:FGSG_00281 ^@ http://purl.uniprot.org/uniprot/I1R9W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05423 ^@ http://purl.uniprot.org/uniprot/I1RN59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 40S cdc5-associated complex (or cwf complex), a spliceosome sub-complex reminiscent of a late-stage spliceosome.|||Belongs to the CWF11 family.|||Involved in mRNA splicing where it associates with cdc5 and the other cwf proteins as part of the spliceosome.|||Nucleus http://togogenome.org/gene/229533:FGSG_10199 ^@ http://purl.uniprot.org/uniprot/I1S0H1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_05298 ^@ http://purl.uniprot.org/uniprot/I1RMU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/229533:FGSG_01226 ^@ http://purl.uniprot.org/uniprot/A0A1I9EY30|||http://purl.uniprot.org/uniprot/Q4INI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||Nucleus|||cytoskeleton http://togogenome.org/gene/229533:FGSG_02534 ^@ http://purl.uniprot.org/uniprot/I1RFQ0 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/229533:FGSG_08940 ^@ http://purl.uniprot.org/uniprot/I1RX87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/229533:FGSG_05063 ^@ http://purl.uniprot.org/uniprot/I1RM80 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_08626 ^@ http://purl.uniprot.org/uniprot/V6RJG0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11254 ^@ http://purl.uniprot.org/uniprot/I1S384 ^@ Function|||Similarity ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family. http://togogenome.org/gene/229533:FGSG_01865 ^@ http://purl.uniprot.org/uniprot/I1RDZ5 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10804 ^@ http://purl.uniprot.org/uniprot/I1S223 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_10192 ^@ http://purl.uniprot.org/uniprot/I1S0G5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/229533:FGSG_01740 ^@ http://purl.uniprot.org/uniprot/I1RDN0 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01484 ^@ http://purl.uniprot.org/uniprot/I1RCZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06769 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKB9|||http://purl.uniprot.org/uniprot/Q4I7N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.|||Nucleus http://togogenome.org/gene/229533:FGSG_03248 ^@ http://purl.uniprot.org/uniprot/I1RHJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06752 ^@ http://purl.uniprot.org/uniprot/V6RF62 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07087 ^@ http://purl.uniprot.org/uniprot/I1RSG9 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/229533:FGSG_09908 ^@ http://purl.uniprot.org/uniprot/I1RZQ6 ^@ Similarity|||Subunit ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer. http://togogenome.org/gene/229533:FGSG_10117 ^@ http://purl.uniprot.org/uniprot/I1S098 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_10629 ^@ http://purl.uniprot.org/uniprot/I1S1M2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_10527 ^@ http://purl.uniprot.org/uniprot/I1S1C7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/229533:FGSG_00012 ^@ http://purl.uniprot.org/uniprot/I1R984 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01176 ^@ http://purl.uniprot.org/uniprot/I1RC73 ^@ Disruption Phenotype|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Interacts with HOG1.|||Nucleus|||Phosphorylation at Thr-82, Ser-92, Ser-102, thr-117 and ser-305 by HOG1 is required for regulating expression of ergosterol biosynthesis genes.|||Reduces the production of ergosterol (PubMed:30874562). Leads to increased sensitivity to azole compounds, but not to iprodione and fludioxonil that target the high osmolarity glycerol (HOG) pathway (PubMed:30874562).|||Transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562). Positively regulates the expression of ergosterol biosynthesis genes including CYP51A and CYP51B encoding the sterol 14-alpha demethylase, and ERG6A and ERG6B encoding the sterol 24-C-methyltransferase (PubMed:30874562). http://togogenome.org/gene/229533:FGSG_05198 ^@ http://purl.uniprot.org/uniprot/I1RMK7 ^@ Similarity ^@ Belongs to the complex I 75 kDa subunit family. http://togogenome.org/gene/229533:FGSG_08053 ^@ http://purl.uniprot.org/uniprot/I1RUZ3 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_05538 ^@ http://purl.uniprot.org/uniprot/Q4IB70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.|||Belongs to the CWC21 family.|||Cytoplasm|||Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).|||Nucleus http://togogenome.org/gene/229533:FGSG_02601 ^@ http://purl.uniprot.org/uniprot/I1RFW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/229533:FGSG_05843 ^@ http://purl.uniprot.org/uniprot/I1RP86 ^@ Function|||Similarity ^@ Belongs to the GPI family.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis. http://togogenome.org/gene/229533:FGSG_03456 ^@ http://purl.uniprot.org/uniprot/I1RI34 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily. http://togogenome.org/gene/229533:FGSG_09300 ^@ http://purl.uniprot.org/uniprot/I1RY63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/229533:FGSG_00217 ^@ http://purl.uniprot.org/uniprot/I1R9R2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07175 ^@ http://purl.uniprot.org/uniprot/I1RSP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02982 ^@ http://purl.uniprot.org/uniprot/I1RGV3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01792 ^@ http://purl.uniprot.org/uniprot/I1RDS7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00659 ^@ http://purl.uniprot.org/uniprot/I1RAW6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_07268 ^@ http://purl.uniprot.org/uniprot/I1RSY1 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/229533:FGSG_00420 ^@ http://purl.uniprot.org/uniprot/Q4IQT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/229533:FGSG_05050 ^@ http://purl.uniprot.org/uniprot/I1RM68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_05847 ^@ http://purl.uniprot.org/uniprot/I1RP90 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_07432 ^@ http://purl.uniprot.org/uniprot/I1RTD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer.|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane. http://togogenome.org/gene/229533:FGSG_01504 ^@ http://purl.uniprot.org/uniprot/I1RD17 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/229533:FGSG_01161 ^@ http://purl.uniprot.org/uniprot/I1RC58 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/229533:FGSG_04092 ^@ http://purl.uniprot.org/uniprot/I1RJR2 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Results in high sensitivity to triadimefon and antifungal azoles such as propiconazole (PubMed:20955812, PubMed:23442154). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).|||Endoplasmic reticulum membrane|||Expression is induced by azole antifungals such as prochloraz, tebuconazole or epoxiconazole (PubMed:23442154). Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol 14-alpha demethylase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:20955812). CYP51A encodes an minor sterol 14-alpha-demethylase induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity (PubMed:20955812). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_10118 ^@ http://purl.uniprot.org/uniprot/I1S099 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_00439 ^@ http://purl.uniprot.org/uniprot/I1RAB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/229533:FGSG_06233 ^@ http://purl.uniprot.org/uniprot/I1RQ94 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09359 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQS6|||http://purl.uniprot.org/uniprot/Q4I099 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit (By similarity).|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00011 ^@ http://purl.uniprot.org/uniprot/I1R983 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04194 ^@ http://purl.uniprot.org/uniprot/V6RAM6 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06141 ^@ http://purl.uniprot.org/uniprot/I1RQ08 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_07425 ^@ http://purl.uniprot.org/uniprot/I1RTC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05395 ^@ http://purl.uniprot.org/uniprot/I1RN33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00610 ^@ http://purl.uniprot.org/uniprot/I1RAS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||actin patch http://togogenome.org/gene/229533:FGSG_11184 ^@ http://purl.uniprot.org/uniprot/I1S323 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_00268 ^@ http://purl.uniprot.org/uniprot/I1R9V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_09518 ^@ http://purl.uniprot.org/uniprot/I1RYR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DUO1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_02141 ^@ http://purl.uniprot.org/uniprot/I1REP7 ^@ Similarity ^@ Belongs to the CDIP1/LITAF family. http://togogenome.org/gene/229533:FGSG_00192 ^@ http://purl.uniprot.org/uniprot/I1R9N9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_07326 ^@ http://purl.uniprot.org/uniprot/I1RT33 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/229533:FGSG_11195 ^@ http://purl.uniprot.org/uniprot/I1S333 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05281 ^@ http://purl.uniprot.org/uniprot/I1RMT4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/229533:FGSG_13830 ^@ http://purl.uniprot.org/uniprot/I1SAE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10052 ^@ http://purl.uniprot.org/uniprot/I1S038 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07415 ^@ http://purl.uniprot.org/uniprot/I1RTB4 ^@ Similarity ^@ Belongs to the SMAP family. http://togogenome.org/gene/229533:FGSG_01982 ^@ http://purl.uniprot.org/uniprot/I1REA0 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_00013 ^@ http://purl.uniprot.org/uniprot/I1R985 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02439 ^@ http://purl.uniprot.org/uniprot/I1RFG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11428 ^@ http://purl.uniprot.org/uniprot/I1S3N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the carbohydrate esterase 1 (CE1) family.|||Esterase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose.|||Secreted http://togogenome.org/gene/229533:FGSG_01300 ^@ http://purl.uniprot.org/uniprot/I1RCI4 ^@ Similarity|||Subunit ^@ Associated with the spliceosome.|||Belongs to the crooked-neck family. http://togogenome.org/gene/229533:FGSG_09099 ^@ http://purl.uniprot.org/uniprot/I1RXM5 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_02872 ^@ http://purl.uniprot.org/uniprot/I1RGK2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_05574 ^@ http://purl.uniprot.org/uniprot/V6RHZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11093 ^@ http://purl.uniprot.org/uniprot/I1S2U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01395 ^@ http://purl.uniprot.org/uniprot/I1RCR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Belongs to the paxM FAD-dependent monooxygenase family.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_02710 ^@ http://purl.uniprot.org/uniprot/I1RG61 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/229533:FGSG_11464 ^@ http://purl.uniprot.org/uniprot/I1S3R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06895 ^@ http://purl.uniprot.org/uniprot/I1RRZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S10 family.|||Vacuolar carboxypeptidase involved in degradation of small peptides. Digests preferentially peptides containing an aliphatic or hydrophobic residue in P1' position, as well as methionine, leucine or phenylalanine in P1 position of ester substrate.|||Vacuole http://togogenome.org/gene/229533:FGSG_08644 ^@ http://purl.uniprot.org/uniprot/I1RWH4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/229533:FGSG_11128 ^@ http://purl.uniprot.org/uniprot/V6RUB1 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/229533:FGSG_02121 ^@ http://purl.uniprot.org/uniprot/I1REM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_08678 ^@ http://purl.uniprot.org/uniprot/I1RWK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/229533:FGSG_05887 ^@ http://purl.uniprot.org/uniprot/I1RPC5 ^@ Similarity ^@ Belongs to the APC13 family. http://togogenome.org/gene/229533:FGSG_09386 ^@ http://purl.uniprot.org/uniprot/I1RYD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the translin family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02751 ^@ http://purl.uniprot.org/uniprot/I1RG95 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_12856 ^@ http://purl.uniprot.org/uniprot/I1S7N3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/229533:FGSG_04803 ^@ http://purl.uniprot.org/uniprot/I1RLK0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05283 ^@ http://purl.uniprot.org/uniprot/I1RMT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10358 ^@ http://purl.uniprot.org/uniprot/Q4HXF0 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer. http://togogenome.org/gene/229533:FGSG_01655 ^@ http://purl.uniprot.org/uniprot/I1RDF9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_01238 ^@ http://purl.uniprot.org/uniprot/V6QW22 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/229533:FGSG_03424 ^@ http://purl.uniprot.org/uniprot/I1RI05 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_03347 ^@ http://purl.uniprot.org/uniprot/V6R610 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11814 ^@ http://purl.uniprot.org/uniprot/I1S4P6 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/229533:FGSG_08333 ^@ http://purl.uniprot.org/uniprot/Q4I375 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM16/PAM16 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).|||Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).|||Mitochondrion inner membrane|||The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity). http://togogenome.org/gene/229533:FGSG_06919 ^@ http://purl.uniprot.org/uniprot/I1RS15 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/229533:FGSG_01801 ^@ http://purl.uniprot.org/uniprot/I1RDT5 ^@ Similarity ^@ Belongs to the glutaminase family. http://togogenome.org/gene/229533:FGSG_09014 ^@ http://purl.uniprot.org/uniprot/I1RXE8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05282 ^@ http://purl.uniprot.org/uniprot/V6RB81 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/229533:FGSG_11629 ^@ http://purl.uniprot.org/uniprot/Q4HTS9 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).|||Belongs to the ISN1 family.|||Homotetramer.|||IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. http://togogenome.org/gene/229533:FGSG_06068 ^@ http://purl.uniprot.org/uniprot/I1RPT8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_05147 ^@ http://purl.uniprot.org/uniprot/I1RMF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11240 ^@ http://purl.uniprot.org/uniprot/I1S371 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_07414 ^@ http://purl.uniprot.org/uniprot/I1RTB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS41 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_03855 ^@ http://purl.uniprot.org/uniprot/I1RJ52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10729 ^@ http://purl.uniprot.org/uniprot/I1S1V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Secreted http://togogenome.org/gene/229533:FGSG_09080 ^@ http://purl.uniprot.org/uniprot/I1RXK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07291 ^@ http://purl.uniprot.org/uniprot/I1RT03 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/229533:FGSG_04290 ^@ http://purl.uniprot.org/uniprot/A0A1I9FG17|||http://purl.uniprot.org/uniprot/Q4IER8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).|||Belongs to the histone H3 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).|||Nucleus|||Phosphorylated to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80. http://togogenome.org/gene/229533:FGSG_08895 ^@ http://purl.uniprot.org/uniprot/V6RIV9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/229533:FGSG_00227 ^@ http://purl.uniprot.org/uniprot/I1R9S1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02593 ^@ http://purl.uniprot.org/uniprot/I1RFV2 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/229533:FGSG_05853 ^@ http://purl.uniprot.org/uniprot/I1RP96 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/229533:FGSG_09724 ^@ http://purl.uniprot.org/uniprot/I1RZ94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09530 ^@ http://purl.uniprot.org/uniprot/A0A1I9FP50|||http://purl.uniprot.org/uniprot/Q4HZS8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_01631 ^@ http://purl.uniprot.org/uniprot/I1RDD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11850 ^@ http://purl.uniprot.org/uniprot/I1S4T3 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Binds to the sequence 5'-CATTCY-3', where Y is a pyrimidine, making both major- and minor-groove contacts (By similarity). Plays a pivotal role in conidiation by regulating cell cycle pathways and other conidiation-related genes (PubMed:24039821).|||Belongs to the TEC1 family.|||Expression is positively regulated by flbD (PubMed:25277408).|||Leads to abnormally shaped phialides and abolishes production of conidia (PubMed:24039821).|||Nucleus http://togogenome.org/gene/229533:FGSG_08339 ^@ http://purl.uniprot.org/uniprot/I1RVQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_02137 ^@ http://purl.uniprot.org/uniprot/I1REP3 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/229533:FGSG_12379 ^@ http://purl.uniprot.org/uniprot/I1S6A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06208 ^@ http://purl.uniprot.org/uniprot/I1RQ69 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/229533:FGSG_13489 ^@ http://purl.uniprot.org/uniprot/I1S9F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42. http://togogenome.org/gene/229533:FGSG_11921 ^@ http://purl.uniprot.org/uniprot/I1S503 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by UBA4. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.|||Belongs to the MoaD family. MOCS2A subfamily.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.|||Cytoplasm|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. http://togogenome.org/gene/229533:FGSG_02523 ^@ http://purl.uniprot.org/uniprot/A0A1I9F2T0|||http://purl.uniprot.org/uniprot/Q4IJT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTP family.|||Involved in protein synthesis. Involved in microtubule stabilization (By similarity).|||cytoskeleton http://togogenome.org/gene/229533:FGSG_09638 ^@ http://purl.uniprot.org/uniprot/I1RZ20 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/229533:FGSG_09595 ^@ http://purl.uniprot.org/uniprot/I1RYY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09124 ^@ http://purl.uniprot.org/uniprot/I1RXQ0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05502 ^@ http://purl.uniprot.org/uniprot/I1RNC9 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/229533:FGSG_09275 ^@ http://purl.uniprot.org/uniprot/V6RNM4 ^@ Similarity ^@ Belongs to the CNOT9 family. http://togogenome.org/gene/229533:FGSG_10139 ^@ http://purl.uniprot.org/uniprot/I1S0B7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_05247 ^@ http://purl.uniprot.org/uniprot/A0A1I9FWW1|||http://purl.uniprot.org/uniprot/Q4IC11 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Component of the GINS complex.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity).|||The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation. http://togogenome.org/gene/229533:FGSG_03385 ^@ http://purl.uniprot.org/uniprot/I1RHW9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/229533:FGSG_02573 ^@ http://purl.uniprot.org/uniprot/I1RFT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08386 ^@ http://purl.uniprot.org/uniprot/I1RVU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_07856 ^@ http://purl.uniprot.org/uniprot/I1RUG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/229533:FGSG_06317 ^@ http://purl.uniprot.org/uniprot/V6RKE4 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/229533:FGSG_07582 ^@ http://purl.uniprot.org/uniprot/V6RHD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06021 ^@ http://purl.uniprot.org/uniprot/I1RPP5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane|||Monomer. http://togogenome.org/gene/229533:FGSG_11856 ^@ http://purl.uniprot.org/uniprot/I1S4T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_10737 ^@ http://purl.uniprot.org/uniprot/I1S1W3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer.|||cytosol http://togogenome.org/gene/229533:FGSG_11938 ^@ http://purl.uniprot.org/uniprot/I1S520 ^@ Similarity ^@ Belongs to the ATP phosphoribosyltransferase family. http://togogenome.org/gene/229533:FGSG_01175 ^@ http://purl.uniprot.org/uniprot/I1RC72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_10167 ^@ http://purl.uniprot.org/uniprot/I1S0E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/229533:FGSG_06818 ^@ http://purl.uniprot.org/uniprot/I1RRT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09770 ^@ http://purl.uniprot.org/uniprot/I1RZD4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04212 ^@ http://purl.uniprot.org/uniprot/I1RK24 ^@ Similarity ^@ Belongs to the GST superfamily. Omega family. http://togogenome.org/gene/229533:FGSG_02316 ^@ http://purl.uniprot.org/uniprot/I1RF50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ABC-type transporter; part of the gene cluster that mediates the biosynthesis of the fusahexin, a cyclic hydrophobic hexapeptide with the amino acid sequence cyclo-(D-Ala-L-Leu-D-allo-Thr-L-Pro-D-Leu-L-Leu) that plays an important role in cell surface hydrophobicity.|||Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane http://togogenome.org/gene/229533:FGSG_06016 ^@ http://purl.uniprot.org/uniprot/I1RPP0 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/229533:FGSG_00500 ^@ http://purl.uniprot.org/uniprot/I1RAH1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/229533:FGSG_08581 ^@ http://purl.uniprot.org/uniprot/V6RKK5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MoaE family. MOCS2B subfamily.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Cytoplasm|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits. http://togogenome.org/gene/229533:FGSG_09284 ^@ http://purl.uniprot.org/uniprot/I1RY49 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03648 ^@ http://purl.uniprot.org/uniprot/V6R4J6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05414 ^@ http://purl.uniprot.org/uniprot/I1RN50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_05669 ^@ http://purl.uniprot.org/uniprot/I1RNT1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol 24-C-methyltransferase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG28 has a role as a scaffold to help anchor the catalytic components of the C-4 demethylation complex ERG25, ERG26 and ERG27 to the endoplasmic reticulum (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_09707 ^@ http://purl.uniprot.org/uniprot/I1RZ80 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_11300 ^@ http://purl.uniprot.org/uniprot/I1S3C3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_01531 ^@ http://purl.uniprot.org/uniprot/I1RD42 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02014 ^@ http://purl.uniprot.org/uniprot/I1REC7 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/229533:FGSG_09872 ^@ http://purl.uniprot.org/uniprot/I1RZM3 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/229533:FGSG_01378 ^@ http://purl.uniprot.org/uniprot/I1RCQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10853 ^@ http://purl.uniprot.org/uniprot/I1S267 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/229533:FGSG_06710 ^@ http://purl.uniprot.org/uniprot/I1RRI7 ^@ Function|||Subcellular Location Annotation ^@ RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_06377 ^@ http://purl.uniprot.org/uniprot/I1RQN1 ^@ Similarity ^@ Belongs to the UPF0696 family. http://togogenome.org/gene/229533:FGSG_04355 ^@ http://purl.uniprot.org/uniprot/I1RKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_07304 ^@ http://purl.uniprot.org/uniprot/I1RT14 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_00137 ^@ http://purl.uniprot.org/uniprot/I1R9J5 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_01027 ^@ http://purl.uniprot.org/uniprot/I1RBT7 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/229533:FGSG_09197 ^@ http://purl.uniprot.org/uniprot/I1RXX1 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ 3-hydroxy-3-methylglutaryl-coenzyme A reductase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). HMG1 catalyzes the reduction of hydroxymethylglutaryl-CoA (HMG-CoA) to mevalonate (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).|||Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter. http://togogenome.org/gene/229533:FGSG_09367 ^@ http://purl.uniprot.org/uniprot/I1RYC2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_08598 ^@ http://purl.uniprot.org/uniprot/I1RWD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPI1/TEX10 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_03120 ^@ http://purl.uniprot.org/uniprot/I1RH75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/229533:FGSG_12611 ^@ http://purl.uniprot.org/uniprot/I1S6Y8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10179 ^@ http://purl.uniprot.org/uniprot/I1S0F5 ^@ Function|||Similarity ^@ Belongs to the MBF1 family.|||Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. http://togogenome.org/gene/229533:FGSG_10347 ^@ http://purl.uniprot.org/uniprot/I1S0V7 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/229533:FGSG_09794 ^@ http://purl.uniprot.org/uniprot/I1RZF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex ASK1 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/229533:FGSG_03432 ^@ http://purl.uniprot.org/uniprot/I1RI12 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_10166 ^@ http://purl.uniprot.org/uniprot/I1S0E2 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ AbaA and wetA are pivotal regulators of conidiophore development and conidium maturation (By similarity). They act individually and together to regulate their own expression and that of numerous other sporulation-specific genes (By similarity). Functions to maintain conidial dormancy by suppressing microcycle conidiation (PubMed:24186953).|||Belongs to the wetA family.|||Expression is positively regulated by flbD (PubMed:25277408).|||Results in abnormal production of conidiophores and conidia, including longer conidia with fewer septa, conidia sensitivity to acute stresses such as oxidative stress and heat stress, and vigorous generation of single-celled conidia through autophagy-dependent microcycle conidiation (PubMed:24186953). Reduces the survival rate of aged conidia (PubMed:24186953). http://togogenome.org/gene/229533:FGSG_01861 ^@ http://purl.uniprot.org/uniprot/I1RDZ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05369 ^@ http://purl.uniprot.org/uniprot/I1RN11 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/229533:FGSG_09572 ^@ http://purl.uniprot.org/uniprot/I1RYW1 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/229533:FGSG_04476 ^@ http://purl.uniprot.org/uniprot/V6R3X5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/229533:FGSG_09587 ^@ http://purl.uniprot.org/uniprot/I1RYX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07055 ^@ http://purl.uniprot.org/uniprot/I1RSD8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_13098 ^@ http://purl.uniprot.org/uniprot/I1S8C0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10053 ^@ http://purl.uniprot.org/uniprot/I1S039 ^@ Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Blocks autophagy (PubMed:28894236). Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation and completely fails to form any perithecia (PubMed:28894236).|||Conjugated to ATG12; which is essential for autophagy (By similarity). Conjugation with ATG12 involves ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme (By similarity).|||Conjugated with ATG12 (By similarity). The ATG5-ATG12 conjugate forms a complex with several units of ATG16 (By similarity). The ATG12-ATG5 conjugate associates also with ATG3 (By similarity).|||Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation (By similarity). Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) (By similarity). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production (By similarity). Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function (By similarity). The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). ATG12-ATG5 rearranges the ATG3 catalytic center and enhances its E2 activity (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Preautophagosomal structure membrane http://togogenome.org/gene/229533:FGSG_05229 ^@ http://purl.uniprot.org/uniprot/I1RMN6 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/229533:FGSG_01690 ^@ http://purl.uniprot.org/uniprot/I1RDJ0 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_01876 ^@ http://purl.uniprot.org/uniprot/I1RE05 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_03481 ^@ http://purl.uniprot.org/uniprot/I1RI56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Secreted http://togogenome.org/gene/229533:FGSG_03020 ^@ http://purl.uniprot.org/uniprot/V6R8J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04166 ^@ http://purl.uniprot.org/uniprot/I1RJY2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/229533:FGSG_01761 ^@ http://purl.uniprot.org/uniprot/I1RDP7 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/229533:FGSG_00345 ^@ http://purl.uniprot.org/uniprot/I1RA27 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06352 ^@ http://purl.uniprot.org/uniprot/I1RQK7 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/229533:FGSG_08099 ^@ http://purl.uniprot.org/uniprot/I1RV37 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08405 ^@ http://purl.uniprot.org/uniprot/I1RVW0 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/229533:FGSG_03231 ^@ http://purl.uniprot.org/uniprot/I1RHH8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06338 ^@ http://purl.uniprot.org/uniprot/Q4I8X0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.|||Cytoplasm|||Monomer.|||Nucleus|||S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA. http://togogenome.org/gene/229533:FGSG_00930 ^@ http://purl.uniprot.org/uniprot/A0A1I9EX23|||http://purl.uniprot.org/uniprot/Q4IPC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSU72 phosphatase family.|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.|||Component of the cleavage and polyadenylation factor (CPF) complex.|||Nucleus|||Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). http://togogenome.org/gene/229533:FGSG_06336 ^@ http://purl.uniprot.org/uniprot/I1RQJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04197 ^@ http://purl.uniprot.org/uniprot/I1RK10 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_10661 ^@ http://purl.uniprot.org/uniprot/V6RTS1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_04334 ^@ http://purl.uniprot.org/uniprot/I1RKD4 ^@ Similarity ^@ Belongs to the lysine N-acyltransferase MbtK family. http://togogenome.org/gene/229533:FGSG_03728 ^@ http://purl.uniprot.org/uniprot/I1RIT4 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_01807 ^@ http://purl.uniprot.org/uniprot/I1RDU0 ^@ Similarity ^@ Belongs to the four-carbon acid sugar kinase family. http://togogenome.org/gene/229533:FGSG_03032 ^@ http://purl.uniprot.org/uniprot/I1RGZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01346 ^@ http://purl.uniprot.org/uniprot/I1RCM5 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/229533:FGSG_08824 ^@ http://purl.uniprot.org/uniprot/I1RWY4 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_03802 ^@ http://purl.uniprot.org/uniprot/I1RJ04 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_06813 ^@ http://purl.uniprot.org/uniprot/I1RRS6 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_01256 ^@ http://purl.uniprot.org/uniprot/I1RCE6 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/229533:FGSG_13185 ^@ http://purl.uniprot.org/uniprot/I1S8K7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_04738 ^@ http://purl.uniprot.org/uniprot/I1RLE2 ^@ Similarity ^@ Belongs to the neutral ceramidase family. http://togogenome.org/gene/229533:FGSG_01887 ^@ http://purl.uniprot.org/uniprot/I1RE15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/229533:FGSG_08459 ^@ http://purl.uniprot.org/uniprot/I1RW07 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/229533:FGSG_08009 ^@ http://purl.uniprot.org/uniprot/I1RUV2 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_09123 ^@ http://purl.uniprot.org/uniprot/I1RXP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11396 ^@ http://purl.uniprot.org/uniprot/I1S3K8 ^@ Function|||Similarity ^@ Amidase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable).|||Belongs to the asparagine synthetase family. http://togogenome.org/gene/229533:FGSG_01194 ^@ http://purl.uniprot.org/uniprot/I1RC91 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/229533:FGSG_01280 ^@ http://purl.uniprot.org/uniprot/I1RCG6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_13662 ^@ http://purl.uniprot.org/uniprot/I1S9Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/229533:FGSG_05797 ^@ http://purl.uniprot.org/uniprot/I1RP45 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/229533:FGSG_13950 ^@ http://purl.uniprot.org/uniprot/I1SAR9 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/229533:FGSG_00437 ^@ http://purl.uniprot.org/uniprot/I1RAB0 ^@ Similarity ^@ Belongs to the TMCO4 family. http://togogenome.org/gene/229533:FGSG_05579 ^@ http://purl.uniprot.org/uniprot/I1RNJ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08381 ^@ http://purl.uniprot.org/uniprot/A0A1I9F8H5|||http://purl.uniprot.org/uniprot/Q4I327 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AATF family.|||nucleolus http://togogenome.org/gene/229533:FGSG_07593 ^@ http://purl.uniprot.org/uniprot/I1RTS7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/229533:FGSG_14036 ^@ http://purl.uniprot.org/uniprot/I1SB04 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MRG family.|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_03356 ^@ http://purl.uniprot.org/uniprot/I1RHU1 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_02117 ^@ http://purl.uniprot.org/uniprot/I1REM5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_02499 ^@ http://purl.uniprot.org/uniprot/I1RFL9 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_01200 ^@ http://purl.uniprot.org/uniprot/I1RC97 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/229533:FGSG_08807 ^@ http://purl.uniprot.org/uniprot/I1RWX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YAE1 family.|||Cytoplasm|||May form a complex with LTO1.|||Nucleus|||The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. http://togogenome.org/gene/229533:FGSG_04579 ^@ http://purl.uniprot.org/uniprot/I1RL05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01328 ^@ http://purl.uniprot.org/uniprot/I1RCK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/229533:FGSG_11658 ^@ http://purl.uniprot.org/uniprot/I1S491 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Abolishes the production of gramillins A and B.|||Nucleus|||Transcription factor that specifically regulates the expression of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves. http://togogenome.org/gene/229533:FGSG_06962 ^@ http://purl.uniprot.org/uniprot/V6RGN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/229533:FGSG_02917 ^@ http://purl.uniprot.org/uniprot/I1RGP4 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_10850 ^@ http://purl.uniprot.org/uniprot/I1S265 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/229533:FGSG_03675 ^@ http://purl.uniprot.org/uniprot/V6R6F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Membrane|||Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_03483 ^@ http://purl.uniprot.org/uniprot/I1RI58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_04739 ^@ http://purl.uniprot.org/uniprot/I1RLE3 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/229533:FGSG_07114 ^@ http://purl.uniprot.org/uniprot/I1RSJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00292 ^@ http://purl.uniprot.org/uniprot/I1R9X7 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/229533:FGSG_03477 ^@ http://purl.uniprot.org/uniprot/I1RI52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05399 ^@ http://purl.uniprot.org/uniprot/I1RN37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00435 ^@ http://purl.uniprot.org/uniprot/I1RAA8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_01375 ^@ http://purl.uniprot.org/uniprot/I1RCQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_09471 ^@ http://purl.uniprot.org/uniprot/I1RYL5 ^@ Function|||Similarity ^@ Belongs to the heat shock protein 70 family.|||Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis. http://togogenome.org/gene/229533:FGSG_02746 ^@ http://purl.uniprot.org/uniprot/I1RG90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.|||Nucleus http://togogenome.org/gene/229533:FGSG_10846 ^@ http://purl.uniprot.org/uniprot/I1S262 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10375 ^@ http://purl.uniprot.org/uniprot/I1S0Y3 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_12586 ^@ http://purl.uniprot.org/uniprot/I1S6W3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_09632 ^@ http://purl.uniprot.org/uniprot/I1RZ14 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum membrane|||Functions as a zinc transporter.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_13910 ^@ http://purl.uniprot.org/uniprot/I1SAM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_00914 ^@ http://purl.uniprot.org/uniprot/I1RBI9 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/229533:FGSG_01871 ^@ http://purl.uniprot.org/uniprot/I1RE01 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/229533:FGSG_07303 ^@ http://purl.uniprot.org/uniprot/I1RT13 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_03901 ^@ http://purl.uniprot.org/uniprot/I1RJ93 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/229533:FGSG_01604 ^@ http://purl.uniprot.org/uniprot/I1RDB0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/229533:FGSG_06354 ^@ http://purl.uniprot.org/uniprot/I1RQK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09568 ^@ http://purl.uniprot.org/uniprot/I1RYV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00231 ^@ http://purl.uniprot.org/uniprot/V6QTX7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02510 ^@ http://purl.uniprot.org/uniprot/I1RFN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/229533:FGSG_08791 ^@ http://purl.uniprot.org/uniprot/I1RWV5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01329 ^@ http://purl.uniprot.org/uniprot/I1RCL0 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/229533:FGSG_03957 ^@ http://purl.uniprot.org/uniprot/I1RJE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03853 ^@ http://purl.uniprot.org/uniprot/I1RJ50 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00058 ^@ http://purl.uniprot.org/uniprot/I1R9C4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00989 ^@ http://purl.uniprot.org/uniprot/I1RBQ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 4 family.|||Secreted http://togogenome.org/gene/229533:FGSG_04253 ^@ http://purl.uniprot.org/uniprot/A0A1I9FEZ4|||http://purl.uniprot.org/uniprot/Q4IEV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the REXO4 family.|||Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).|||Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs.|||Nucleus http://togogenome.org/gene/229533:FGSG_06784 ^@ http://purl.uniprot.org/uniprot/V6RG22 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the FPP/GGPP synthase family.|||Binds 2 Mg(2+) ions per subunit.|||Farnesyl pyrophosphate synthase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable). http://togogenome.org/gene/229533:FGSG_01496 ^@ http://purl.uniprot.org/uniprot/I1RD09 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/229533:FGSG_01712 ^@ http://purl.uniprot.org/uniprot/V6QYL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02525 ^@ http://purl.uniprot.org/uniprot/I1RFP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/229533:FGSG_08714 ^@ http://purl.uniprot.org/uniprot/I1RWN6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/229533:FGSG_01939 ^@ http://purl.uniprot.org/uniprot/I1RE63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family.|||Mitochondrion|||N-acetylglutamate synthase involved in arginine biosynthesis. http://togogenome.org/gene/229533:FGSG_10911 ^@ http://purl.uniprot.org/uniprot/Q4HVU7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Homodimer.|||Mitochondrion inner membrane|||Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). http://togogenome.org/gene/229533:FGSG_08648 ^@ http://purl.uniprot.org/uniprot/I1RWH8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/229533:FGSG_04482 ^@ http://purl.uniprot.org/uniprot/I1RKR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11488 ^@ http://purl.uniprot.org/uniprot/I1S3U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_03460 ^@ http://purl.uniprot.org/uniprot/I1RI38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_10723 ^@ http://purl.uniprot.org/uniprot/I1S1V1 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/229533:FGSG_07299 ^@ http://purl.uniprot.org/uniprot/I1RT09 ^@ Similarity ^@ Belongs to the GcvT family. CAF17 subfamily. http://togogenome.org/gene/229533:FGSG_09453 ^@ http://purl.uniprot.org/uniprot/I1RYJ7 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/229533:FGSG_05336 ^@ http://purl.uniprot.org/uniprot/A0A1I9FQK1|||http://purl.uniprot.org/uniprot/Q4IBS2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_03243 ^@ http://purl.uniprot.org/uniprot/I1RHI8 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_01574 ^@ http://purl.uniprot.org/uniprot/I1RD82 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG27 family.|||Cytoplasmic vesicle membrane|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236).|||Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling (By similarity). Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation (By similarity). Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Forms a complex with ATG9 and ATG23 (By similarity).|||Golgi apparatus membrane|||Mitochondrion membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/229533:FGSG_11561 ^@ http://purl.uniprot.org/uniprot/I1S409 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01949 ^@ http://purl.uniprot.org/uniprot/I1RE72 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/229533:FGSG_08281 ^@ http://purl.uniprot.org/uniprot/I1RVK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Membrane http://togogenome.org/gene/229533:FGSG_09960 ^@ http://purl.uniprot.org/uniprot/I1RZV5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05571 ^@ http://purl.uniprot.org/uniprot/I1RNJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04347 ^@ http://purl.uniprot.org/uniprot/I1RKE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07112 ^@ http://purl.uniprot.org/uniprot/I1RSJ1 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/229533:FGSG_08722 ^@ http://purl.uniprot.org/uniprot/I1RWP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LCL3 family.|||Cytoplasm|||Membrane|||Mitochondrion http://togogenome.org/gene/229533:FGSG_06767 ^@ http://purl.uniprot.org/uniprot/I1RRN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/229533:FGSG_04428 ^@ http://purl.uniprot.org/uniprot/I1RKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HRI1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_02833 ^@ http://purl.uniprot.org/uniprot/I1RGH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05641 ^@ http://purl.uniprot.org/uniprot/I1RNQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RPAP2 family.|||Nucleus|||Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. http://togogenome.org/gene/229533:FGSG_08871 ^@ http://purl.uniprot.org/uniprot/I1RX25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04312 ^@ http://purl.uniprot.org/uniprot/V6R3J1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/229533:FGSG_05371 ^@ http://purl.uniprot.org/uniprot/I1RN13 ^@ Cofactor|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subunit ^@ Belongs to the lysine N(6)-hydroxylase/L-ornithine N(5)-oxygenase family.|||Binds 1 FAD per subunit.|||Expression is induced under iron starvation conditions (PubMed:20507510).|||Homotetramer.|||Impairs the production of siderophores and leads to slow growth under low iron conditions (PubMed:20507510). Does not affect the ability to infect single, inoculated spikelets, but prevents the spreading from spikelet-to-spikelet through the rachises of wheat spikes (PubMed:20507510).|||L-ornithine N(5)-monooxygenase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:20507510). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875). http://togogenome.org/gene/229533:FGSG_07533 ^@ http://purl.uniprot.org/uniprot/I1RTM2 ^@ Similarity ^@ Belongs to the pectinesterase family. http://togogenome.org/gene/229533:FGSG_00348 ^@ http://purl.uniprot.org/uniprot/V6R0U9 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/229533:FGSG_03414 ^@ http://purl.uniprot.org/uniprot/I1RHZ5 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/229533:FGSG_10255 ^@ http://purl.uniprot.org/uniprot/I1S0M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_10835 ^@ http://purl.uniprot.org/uniprot/I1S251 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06408 ^@ http://purl.uniprot.org/uniprot/I1RQR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIF1/spd1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06924 ^@ http://purl.uniprot.org/uniprot/I1RS18 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/229533:FGSG_11029 ^@ http://purl.uniprot.org/uniprot/I1S2N0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08988 ^@ http://purl.uniprot.org/uniprot/I1RXC4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/229533:FGSG_07554 ^@ http://purl.uniprot.org/uniprot/I1RTP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Membrane http://togogenome.org/gene/229533:FGSG_10080 ^@ http://purl.uniprot.org/uniprot/I1S064 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/229533:FGSG_07539 ^@ http://purl.uniprot.org/uniprot/I1RTM8 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_01230 ^@ http://purl.uniprot.org/uniprot/I1RCC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_05471 ^@ http://purl.uniprot.org/uniprot/V6RAZ6 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_05973 ^@ http://purl.uniprot.org/uniprot/I1RPK1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/229533:FGSG_04581 ^@ http://purl.uniprot.org/uniprot/I1RL07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02400 ^@ http://purl.uniprot.org/uniprot/I1RFC8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_09576 ^@ http://purl.uniprot.org/uniprot/I1RYW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10507 ^@ http://purl.uniprot.org/uniprot/I1S1A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM53 family.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/229533:FGSG_05584 ^@ http://purl.uniprot.org/uniprot/I1RNK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_01453 ^@ http://purl.uniprot.org/uniprot/I1RCX0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02115 ^@ http://purl.uniprot.org/uniprot/I1REM3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02561 ^@ http://purl.uniprot.org/uniprot/I1RFS3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_13625 ^@ http://purl.uniprot.org/uniprot/I1S9U4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10791 ^@ http://purl.uniprot.org/uniprot/A0A1I9FTE5|||http://purl.uniprot.org/uniprot/Q4HW67 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.|||P-body|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_06723 ^@ http://purl.uniprot.org/uniprot/Q4I7T5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM14 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).|||Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).|||Mitochondrion inner membrane|||The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16. http://togogenome.org/gene/229533:FGSG_01046 ^@ http://purl.uniprot.org/uniprot/I1RBV5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/229533:FGSG_13883 ^@ http://purl.uniprot.org/uniprot/I1SAK2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/229533:FGSG_07325 ^@ http://purl.uniprot.org/uniprot/I1RT32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01923 ^@ http://purl.uniprot.org/uniprot/I1RE49 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/229533:FGSG_00367 ^@ http://purl.uniprot.org/uniprot/I1RA43 ^@ Subcellular Location Annotation|||Subunit ^@ Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/229533:FGSG_05300 ^@ http://purl.uniprot.org/uniprot/I1RMV0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''. http://togogenome.org/gene/229533:FGSG_06480 ^@ http://purl.uniprot.org/uniprot/I1RQX9 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. http://togogenome.org/gene/229533:FGSG_01553 ^@ http://purl.uniprot.org/uniprot/I1RD64 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/229533:FGSG_04026 ^@ http://purl.uniprot.org/uniprot/I1RJK3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/229533:FGSG_13276 ^@ http://purl.uniprot.org/uniprot/I1S8U8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10875 ^@ http://purl.uniprot.org/uniprot/I1S289 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.|||Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.|||Cytoplasm|||P-body http://togogenome.org/gene/229533:FGSG_11169 ^@ http://purl.uniprot.org/uniprot/I1S308 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 27 family. http://togogenome.org/gene/229533:FGSG_00364 ^@ http://purl.uniprot.org/uniprot/I1RA41 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/229533:FGSG_04610 ^@ http://purl.uniprot.org/uniprot/I1RL30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07399 ^@ http://purl.uniprot.org/uniprot/I1RT98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/229533:FGSG_06215 ^@ http://purl.uniprot.org/uniprot/I1RQ76 ^@ Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Endoplasmic reticulum membrane|||Expression is significantly lower when CYP51A or CYP51C are deleted.|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Lipid droplet|||Microsome membrane|||Squalene epoxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG1 catalyzes the epoxidation of squalene into 2,3-epoxysqualene (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_00015 ^@ http://purl.uniprot.org/uniprot/I1R987 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_09584 ^@ http://purl.uniprot.org/uniprot/V6RPQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_05984 ^@ http://purl.uniprot.org/uniprot/I1RPL1 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/229533:FGSG_05985 ^@ http://purl.uniprot.org/uniprot/I1RPL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_00702 ^@ http://purl.uniprot.org/uniprot/I1RB03 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GT2 glycosyltransferase family.|||Cell membrane|||Expression is induced during hyphal growth.|||Glycosyltransferase involved in the maintenance of the outermost surface of the fungal cell wall (PubMed:29020037). Likely functions in the synthesis of a currently unknown, potentially minor but widespread, extracellular or outer cell wall polysaccharide which plays a key role in facilitating many interactions between plants and fungi by enabling hyphal growth on solid matrices (PubMed:29020037).|||Severely impairs hyphal growth and pathogenicity on wheat leaves (PubMed:29020037). Does not affect adhesion to leaf surfaces (PubMed:29020037). Leads to constitutive overexpression of several transmembrane and secreted proteins, including an important LysM-domain chitin-binding virulence effector, LysM (PubMed:29020037).|||cell wall http://togogenome.org/gene/229533:FGSG_13369 ^@ http://purl.uniprot.org/uniprot/I1S939 ^@ Similarity ^@ Belongs to the PhyH family. http://togogenome.org/gene/229533:FGSG_00524 ^@ http://purl.uniprot.org/uniprot/I1RAJ4 ^@ Function|||Similarity ^@ Belongs to the UDPGP type 1 family.|||Plays a central role as a glucosyl donor in cellular metabolic pathways. http://togogenome.org/gene/229533:FGSG_00511 ^@ http://purl.uniprot.org/uniprot/I1RAI1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08265 ^@ http://purl.uniprot.org/uniprot/I1RVI7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_08593 ^@ http://purl.uniprot.org/uniprot/I1RWC9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/229533:FGSG_02073 ^@ http://purl.uniprot.org/uniprot/I1REI4 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/229533:FGSG_01540 ^@ http://purl.uniprot.org/uniprot/I1RD51 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/229533:FGSG_06749 ^@ http://purl.uniprot.org/uniprot/I1RRL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07668 ^@ http://purl.uniprot.org/uniprot/I1RTZ8 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_06518 ^@ http://purl.uniprot.org/uniprot/V6RDX9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_06533 ^@ http://purl.uniprot.org/uniprot/I1RR26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02987 ^@ http://purl.uniprot.org/uniprot/I1RGV7 ^@ Similarity ^@ Belongs to the tannase family. http://togogenome.org/gene/229533:FGSG_01803 ^@ http://purl.uniprot.org/uniprot/I1RDT7 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase.|||Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. http://togogenome.org/gene/229533:FGSG_11439 ^@ http://purl.uniprot.org/uniprot/I1S3P8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05128 ^@ http://purl.uniprot.org/uniprot/I1RMD9 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_09775 ^@ http://purl.uniprot.org/uniprot/I1RZD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_05937 ^@ http://purl.uniprot.org/uniprot/I1RPG8 ^@ Similarity ^@ Belongs to the serine esterase family. http://togogenome.org/gene/229533:FGSG_00505 ^@ http://purl.uniprot.org/uniprot/I1RAH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/229533:FGSG_09140 ^@ http://purl.uniprot.org/uniprot/I1RXR5 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/229533:FGSG_05141 ^@ http://purl.uniprot.org/uniprot/I1RMF2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Alternates between an inactive form bound to GDP and an active form bound to GTP. Activated by guanine nucleotide-exchange factors (GEFs), and inactivated by GTPase-activating proteins (GAPs).|||Belongs to the small GTPase superfamily. Rab family.|||Late endosome membrane|||Vacuole membrane|||Ypt/Rab-type GTPases are key regulators of membrane trafficking and intracellular vesicular transport. They act as molecular switches that convert between GTP-bound and GDP-bound states, and regulate virtually all steps of membrane traffic from the formation of the transport vesicle at the donor membrane to its fusion at the target membrane. In the GDP-bound state, Ypt proteins are predominantly cytosolic, solubilized through the interaction with a GDP dissociation inhibitor (GDI). In the GTP-bound state, the proteins are membrane bound and interact with specific effector proteins that select cargo, promote vesicle movement, or verify the correct site of fusion (By similarity). RAB7 regulates the fusion of vacuoles and autophagosomes (PubMed:26177389). Required for ATG9 trafficking (PubMed:30044782). http://togogenome.org/gene/229533:FGSG_05238 ^@ http://purl.uniprot.org/uniprot/I1RMP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05038 ^@ http://purl.uniprot.org/uniprot/A0A1I9FSY6|||http://purl.uniprot.org/uniprot/Q4ICM0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for nuclear migration during vegetative growth as well as development. Required for retrograde early endosome (EE) transport from the hyphal tip. Required for localization of dynein to the mitotic spindle poles. Recruits additional proteins to the dynein complex at SPBs.|||Self-associates. Interacts with NDL1 and dynein.|||cytoskeleton|||spindle pole http://togogenome.org/gene/229533:FGSG_04188 ^@ http://purl.uniprot.org/uniprot/I1RK04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01430 ^@ http://purl.uniprot.org/uniprot/I1RCU8 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/229533:FGSG_04483 ^@ http://purl.uniprot.org/uniprot/I1RKR7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/229533:FGSG_01580 ^@ http://purl.uniprot.org/uniprot/I1RD88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11453 ^@ http://purl.uniprot.org/uniprot/I1S3Q8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05884 ^@ http://purl.uniprot.org/uniprot/I1RPC2 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/229533:FGSG_08264 ^@ http://purl.uniprot.org/uniprot/I1RVI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13527 ^@ http://purl.uniprot.org/uniprot/I1S9J6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05105 ^@ http://purl.uniprot.org/uniprot/I1RMB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_08926 ^@ http://purl.uniprot.org/uniprot/I1RX76 ^@ Subunit ^@ Component of the ESCRT-0 complex composed of HSE1 and VPS27. http://togogenome.org/gene/229533:FGSG_09871 ^@ http://purl.uniprot.org/uniprot/I1RZM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_11355 ^@ http://purl.uniprot.org/uniprot/I1S3H3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05159 ^@ http://purl.uniprot.org/uniprot/I1RMG9 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the multicopper oxidase family.|||Cell membrane|||Cell surface ferroxidase; part of the reductive iron assimilatory system (RIA), a siderophore-independent iron acquisition process (PubMed:20507510). Required to oxidize Fe(2+) and release it from the transporter (By similarity). Seems not to be involved in virulence (PubMed:20507510).|||Expression is up-regulated during iron starvation (PubMed:20507510).|||Produces wild-type amounts of siderophores and growth at the same rate as the wild-type under iron limitation, but accumulates high levels of free intracellular iron (PubMed:20507510). Does not affect the virulence (PubMed:20507510). http://togogenome.org/gene/229533:FGSG_07090 ^@ http://purl.uniprot.org/uniprot/I1RSH1 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/229533:FGSG_10481 ^@ http://purl.uniprot.org/uniprot/I1S182 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_00551 ^@ http://purl.uniprot.org/uniprot/I1RAL9 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/229533:FGSG_01407 ^@ http://purl.uniprot.org/uniprot/I1RCT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Membrane http://togogenome.org/gene/229533:FGSG_04044 ^@ http://purl.uniprot.org/uniprot/I1RJL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/229533:FGSG_02192 ^@ http://purl.uniprot.org/uniprot/I1REU1 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/229533:FGSG_13551 ^@ http://purl.uniprot.org/uniprot/I1S9M0 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/229533:FGSG_03071 ^@ http://purl.uniprot.org/uniprot/I1RH32 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_07042 ^@ http://purl.uniprot.org/uniprot/I1RSC6 ^@ Similarity ^@ Belongs to the TMA16 family. http://togogenome.org/gene/229533:FGSG_01486 ^@ http://purl.uniprot.org/uniprot/I1RCZ9 ^@ Similarity ^@ Belongs to the class-II DAHP synthase family. http://togogenome.org/gene/229533:FGSG_01926 ^@ http://purl.uniprot.org/uniprot/I1RE52 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/229533:FGSG_07734 ^@ http://purl.uniprot.org/uniprot/I1RU52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10818 ^@ http://purl.uniprot.org/uniprot/I1S234 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/229533:FGSG_04117 ^@ http://purl.uniprot.org/uniprot/I1RJT5 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. http://togogenome.org/gene/229533:FGSG_01125 ^@ http://purl.uniprot.org/uniprot/I1RC24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/229533:FGSG_03242 ^@ http://purl.uniprot.org/uniprot/I1RHI7 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family.|||Belongs to the glycosyltransferase 77 family. http://togogenome.org/gene/229533:FGSG_01265 ^@ http://purl.uniprot.org/uniprot/V6R3U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Membrane http://togogenome.org/gene/229533:FGSG_01722 ^@ http://purl.uniprot.org/uniprot/I1RDL3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_08800 ^@ http://purl.uniprot.org/uniprot/I1RWW4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06859 ^@ http://purl.uniprot.org/uniprot/I1RRW2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/229533:FGSG_01686 ^@ http://purl.uniprot.org/uniprot/V6R556 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02306 ^@ http://purl.uniprot.org/uniprot/I1RF40 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/229533:FGSG_02359 ^@ http://purl.uniprot.org/uniprot/I1RF90 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_10387 ^@ http://purl.uniprot.org/uniprot/I1S0Z5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/229533:FGSG_02584 ^@ http://purl.uniprot.org/uniprot/A0A1I9F2M1|||http://purl.uniprot.org/uniprot/Q4IJM4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||Catalytic Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes.|||Component of the COP9 signalosome (CSN) complex.|||Cytoplasm|||Nucleus|||The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity). http://togogenome.org/gene/229533:FGSG_01502 ^@ http://purl.uniprot.org/uniprot/I1RD15 ^@ Similarity ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily. http://togogenome.org/gene/229533:FGSG_00147 ^@ http://purl.uniprot.org/uniprot/I1R9K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06743 ^@ http://purl.uniprot.org/uniprot/I1RRL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_06615 ^@ http://purl.uniprot.org/uniprot/I1RR99 ^@ Similarity ^@ Belongs to the WD repeat MET30/SCONB/SCON-2 family. http://togogenome.org/gene/229533:FGSG_01435 ^@ http://purl.uniprot.org/uniprot/I1RCV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11219 ^@ http://purl.uniprot.org/uniprot/I1S354 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00257 ^@ http://purl.uniprot.org/uniprot/I1R9U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_05138 ^@ http://purl.uniprot.org/uniprot/I1RME9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CWC2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05682 ^@ http://purl.uniprot.org/uniprot/I1RNU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08817 ^@ http://purl.uniprot.org/uniprot/I1RWY0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/229533:FGSG_02349 ^@ http://purl.uniprot.org/uniprot/I1RF82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_10863 ^@ http://purl.uniprot.org/uniprot/I1S277 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/229533:FGSG_07189 ^@ http://purl.uniprot.org/uniprot/V6RGM9 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_01311 ^@ http://purl.uniprot.org/uniprot/I1RCJ4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_00824 ^@ http://purl.uniprot.org/uniprot/I1RBB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family.|||coated pit http://togogenome.org/gene/229533:FGSG_08888 ^@ http://purl.uniprot.org/uniprot/I1RX39 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6A family. http://togogenome.org/gene/229533:FGSG_10033 ^@ http://purl.uniprot.org/uniprot/I1S021 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/229533:FGSG_06721 ^@ http://purl.uniprot.org/uniprot/I1RRJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. Involved in non-homologous end joining (NHEJ) DNA double strand break repair. DNA-binding is sequence-independent but has a high affinity to nicks in double-stranded DNA and to the ends of duplex DNA. Binds to naturally occurring chromosomal ends, and therefore provides chromosomal end protection. Required also for telomere recombination to repair telomeric ends in the absence of telomerase. KU70, of the KU70/KU80 heterodimer, binds to the stem loop of TLC1, the RNA component of telomerase. Involved in telomere maintenance. Interacts with telomeric repeats and subtelomeric sequences thereby controlling telomere length and protecting against subtelomeric rearrangement. Maintains telomeric chromatin, which is involved in silencing the expression of genes located at the telomere. Required for mating-type switching.|||telomere http://togogenome.org/gene/229533:FGSG_02330 ^@ http://purl.uniprot.org/uniprot/I1RF64 ^@ Disruption Phenotype|||Function|||Induction|||Similarity ^@ Belongs to the multicopper oxidase family.|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16461721).|||Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:16879655).|||Multicopper oxidase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881). http://togogenome.org/gene/229533:FGSG_11671 ^@ http://purl.uniprot.org/uniprot/I1S4A4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_04544 ^@ http://purl.uniprot.org/uniprot/I1RKX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_11467 ^@ http://purl.uniprot.org/uniprot/I1S3S1 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family.|||Belongs to the glycosyltransferase 77 family. http://togogenome.org/gene/229533:FGSG_09366 ^@ http://purl.uniprot.org/uniprot/I1RYC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/229533:FGSG_02233 ^@ http://purl.uniprot.org/uniprot/I1REX4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_06821 ^@ http://purl.uniprot.org/uniprot/I1RRT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. Within the NOP7 complex ERB1 appears to interact directly with NOP7 and YTM1. The NOP7 complex also associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_01054 ^@ http://purl.uniprot.org/uniprot/I1RBW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-K/MCM22 family.|||Nucleus|||centromere http://togogenome.org/gene/229533:FGSG_00429 ^@ http://purl.uniprot.org/uniprot/I1RAA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03219 ^@ http://purl.uniprot.org/uniprot/I1RHG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05079 ^@ http://purl.uniprot.org/uniprot/I1RM94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytoskeleton http://togogenome.org/gene/229533:FGSG_06019 ^@ http://purl.uniprot.org/uniprot/I1RPP3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/229533:FGSG_06508 ^@ http://purl.uniprot.org/uniprot/I1RR06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04410 ^@ http://purl.uniprot.org/uniprot/I1RKK0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/229533:FGSG_00719 ^@ http://purl.uniprot.org/uniprot/I1RB16 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01443 ^@ http://purl.uniprot.org/uniprot/I1RCW0 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/229533:FGSG_03111 ^@ http://purl.uniprot.org/uniprot/I1RH67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09177 ^@ http://purl.uniprot.org/uniprot/I1RXV1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09303 ^@ http://purl.uniprot.org/uniprot/I1RY66 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_00656 ^@ http://purl.uniprot.org/uniprot/I1RAW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane http://togogenome.org/gene/229533:FGSG_00503 ^@ http://purl.uniprot.org/uniprot/I1RAH3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/229533:FGSG_01591 ^@ http://purl.uniprot.org/uniprot/I1RD99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_13826 ^@ http://purl.uniprot.org/uniprot/I1SAE5 ^@ Similarity ^@ Belongs to the peptidase S8 family. Furin subfamily. http://togogenome.org/gene/229533:FGSG_11125 ^@ http://purl.uniprot.org/uniprot/I1S2W9 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_12821 ^@ http://purl.uniprot.org/uniprot/I1S7J8 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_09660 ^@ http://purl.uniprot.org/uniprot/I1RZ37 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/229533:FGSG_05154 ^@ http://purl.uniprot.org/uniprot/I1RMG4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/229533:FGSG_07488 ^@ http://purl.uniprot.org/uniprot/I1RTI0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02418 ^@ http://purl.uniprot.org/uniprot/I1RFE4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_05074 ^@ http://purl.uniprot.org/uniprot/I1RM89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the histone H4 family.|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/229533:FGSG_08900 ^@ http://purl.uniprot.org/uniprot/I1RX50 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG3 family.|||Cytoplasm|||E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8 (By similarity). The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE) (By similarity). This step is required for the membrane association of ATG8 (By similarity). The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt) (By similarity). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Monomer (By similarity). Interacts with ATG8 through an intermediate thioester bond between Cys-244 and the C-terminal Gly of ATG8 (By similarity). Interacts with the C-terminal region of the E1-like ATG7 enzyme (By similarity). Interacts also with the ATG12-ATG5 conjugate (By similarity).|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation (By similarity).|||The flexible region (FR) is required for ATG7-binding (By similarity).|||The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8 (By similarity). It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity). http://togogenome.org/gene/229533:FGSG_03360 ^@ http://purl.uniprot.org/uniprot/I1RHU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13839 ^@ http://purl.uniprot.org/uniprot/I1SAF8 ^@ Similarity ^@ Belongs to the PheA/TfdB FAD monooxygenase family.|||Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_05372 ^@ http://purl.uniprot.org/uniprot/I1RN14 ^@ Disruption Phenotype|||Domain|||Function|||Similarity ^@ Belongs to the NRP synthetase family.|||Leads to defective intracellular siderophore (ferricrocin) biosynthesis and sexual development (PubMed:17601875).|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module (By similarity). Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product (By similarity). Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme (By similarity). Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase (By similarity). NPS2 has the following architecture: A-T-C-A-T-C-A-T-C-A-T-C-T-C-T-C (PubMed:17043871).|||Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of hydroxamate-containing siderophores that play a critical role in virulence (PubMed:17043871, PubMed:17601875). Gibberella zeae produces extracellular coprogen-type siderophores as well as the intracellular siderophore ferricrocin (PubMed:17056706). The role of extracellular siderophores is to supply iron to the fungus during plant infection, and the intracellular ferricrocin is required for intracellular iron distribution and storage with a crucial role in ascus and ascospore development (PubMed:17056706, PubMed:17043871, PubMed:17601875). SID1 catalyzes the conversion of L-ornithine to N(5)-hydroxyornithine, the first step in the biosynthesis of all hydroxamate-containing siderophores (PubMed:20507510). The assembly of extracellular coprogen-type siderophores is performed by the nonribosomal peptide synthetase (NRPS) NPS6 whereas the intracellular siderophore ferricrocin is assembled by NPS2 (PubMed:17056706, PubMed:17043871, PubMed:17601875). http://togogenome.org/gene/229533:FGSG_01349 ^@ http://purl.uniprot.org/uniprot/I1RCM8 ^@ Similarity ^@ Belongs to the diacylglycerol acyltransferase family. http://togogenome.org/gene/229533:FGSG_07046 ^@ http://purl.uniprot.org/uniprot/I1RSD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/229533:FGSG_05327 ^@ http://purl.uniprot.org/uniprot/I1RMX4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/229533:FGSG_04914 ^@ http://purl.uniprot.org/uniprot/I1RLU5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_02870 ^@ http://purl.uniprot.org/uniprot/I1RGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_03214 ^@ http://purl.uniprot.org/uniprot/I1RHG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12302 ^@ http://purl.uniprot.org/uniprot/Q4IF76 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.|||Associates with polysomes.|||Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||Cytoplasm|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_05512 ^@ http://purl.uniprot.org/uniprot/Q4IB96 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF1 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_08179 ^@ http://purl.uniprot.org/uniprot/I1RVB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06139 ^@ http://purl.uniprot.org/uniprot/I1RQ06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05888 ^@ http://purl.uniprot.org/uniprot/I1RPC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Part of the multisubunit TRAPP (transport protein particle) complex.|||Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.|||cis-Golgi network http://togogenome.org/gene/229533:FGSG_02051 ^@ http://purl.uniprot.org/uniprot/I1REG3 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/229533:FGSG_11139 ^@ http://purl.uniprot.org/uniprot/I1S2Y1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06094 ^@ http://purl.uniprot.org/uniprot/I1RPW2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.|||Heterodimer of an alpha and a beta chain.|||Mitochondrion matrix|||The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion. http://togogenome.org/gene/229533:FGSG_06777 ^@ http://purl.uniprot.org/uniprot/V6RLW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_06221 ^@ http://purl.uniprot.org/uniprot/I1RQ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06154 ^@ http://purl.uniprot.org/uniprot/I1RQ21 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/229533:FGSG_00172 ^@ http://purl.uniprot.org/uniprot/I1R9M3 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_11036 ^@ http://purl.uniprot.org/uniprot/I1S2N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the faeC family.|||Involved in degradation of plant cell walls. Hydrolyzes the feruloyl-arabinose ester bond in arabinoxylans, and the feruloyl-galactose ester bond in pectin. Active against paranitrophenyl-acetate, methyl ferulate and wheat arabinoxylan.|||Secreted http://togogenome.org/gene/229533:FGSG_05454 ^@ http://purl.uniprot.org/uniprot/I1RN88 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/229533:FGSG_07380 ^@ http://purl.uniprot.org/uniprot/I1RT81 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/229533:FGSG_04187 ^@ http://purl.uniprot.org/uniprot/I1RK03 ^@ Similarity ^@ Belongs to the pantothenate synthetase family. http://togogenome.org/gene/229533:FGSG_07322 ^@ http://purl.uniprot.org/uniprot/I1RT30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06864 ^@ http://purl.uniprot.org/uniprot/I1RRW5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_07248 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJB8|||http://purl.uniprot.org/uniprot/Q4I6B0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit.|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins.|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space.|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/229533:FGSG_01782 ^@ http://purl.uniprot.org/uniprot/I1RDR7 ^@ Similarity ^@ Belongs to the OsmC/Ohr family. http://togogenome.org/gene/229533:FGSG_09577 ^@ http://purl.uniprot.org/uniprot/I1RYW6 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily. http://togogenome.org/gene/229533:FGSG_07967 ^@ http://purl.uniprot.org/uniprot/I1RUR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INP1 family.|||Membrane|||Peroxisome membrane|||Required for peroxisome inheritance. http://togogenome.org/gene/229533:FGSG_07888 ^@ http://purl.uniprot.org/uniprot/V6RI16 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/229533:FGSG_01006 ^@ http://purl.uniprot.org/uniprot/I1RBR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10990 ^@ http://purl.uniprot.org/uniprot/I1S2J4 ^@ Disruption Phenotype|||Domain|||Function|||Induction|||Similarity ^@ Belongs to the NRP synthetase family.|||Expression is positively regulated by the cluster-specific transcription factor FGM4 and is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). Expression is also up-regulated during infection of barley (PubMed:21585270). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Leads to reduced virulence.|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. NRPS9 has a reduced A-T architecture.|||Nonribosomal peptide synthetase; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). The 2 nonribosomal peptide synthetases NRPS9 and NRPS5 form an assembly line which likely utilizes GABA as a starter unit (loaded on the unique module M1 of NRPS9) and sequentially incorporates seven extender units composed of the residues L-Ala, L-allo-Ile, L-Ser, L-Val, L-Ser, L-Leu and L-Leu, respectively (PubMed:30804501, PubMed:31100892). During the process, each of the residues that are tethered on modules M3-M7 of NRPS5 containing an E domain can undergo an epimerization reaction to produce a D-configuration before the transpeptidation reaction occurs (PubMed:30804501, PubMed:31100892). The elongation of the peptidyl chain might be terminated by module M8-mediated L-Leu incorporation, followed by R domain-catalyzed 4 electron reduction to release the resulting octapeptide from the assembly line as an alcohol (PubMed:30804501, PubMed:31100892). Fusaoctaxin A is cleaved by the cluster specific ABC transporter FGM5 to the pentapeptide fusapentaxin A and the tripeptide fusatrixin A (PubMed:31100892). The other enzymes from the cluster, FGM1, FGM2, FGM3 and FGM9 seem not to be involved in the biosynthesis of fusaoctaxin A and their functions have still to be determined (Probable). http://togogenome.org/gene/229533:FGSG_08712 ^@ http://purl.uniprot.org/uniprot/V6RRM0 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/229533:FGSG_05836 ^@ http://purl.uniprot.org/uniprot/I1RP80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06214 ^@ http://purl.uniprot.org/uniprot/I1RQ75 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/229533:FGSG_11977 ^@ http://purl.uniprot.org/uniprot/I1S559 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_03793 ^@ http://purl.uniprot.org/uniprot/I1RIZ5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00637 ^@ http://purl.uniprot.org/uniprot/I1RAU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/229533:FGSG_09423 ^@ http://purl.uniprot.org/uniprot/I1RYH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/229533:FGSG_06954 ^@ http://purl.uniprot.org/uniprot/I1RS46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_08298 ^@ http://purl.uniprot.org/uniprot/I1RVL7 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/229533:FGSG_08552 ^@ http://purl.uniprot.org/uniprot/I1RW91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_13380 ^@ http://purl.uniprot.org/uniprot/I1S950 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/229533:FGSG_01000 ^@ http://purl.uniprot.org/uniprot/I1RBR4 ^@ Disruption Phenotype|||Function|||Induction|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Decreases the amounts of 4,4-dimethylergosta-8,14,24(28)-trienol, the product of the Fusarium sterol 14-alpha demethylases; and leads to the accumulation of eburicol and 2 additional 14-methylated sterols, 4,4,14-trimethylergosta-trienol and 4,4,14-trimethylergosta-dienol (PubMed:23442154). Leads to reduced ability to produce conidia (PubMed:20955812). Affects ergosterol production in the presence of ebuconazole or triadimefon (PubMed:20955812). Host-induced gene silencing of the 3 genes encoding sterol C14-alpha-demethylase leads to strong resistance of host to Fusarium species (PubMed:24218613).|||Endoplasmic reticulum membrane|||Expression is increased in the absence of the C-24(28) sterol reductase ERG4 (PubMed:22947191). Expression is positively regulated by the FgSR transcription factor that targets gene promoters containing 2 conserved CGAA repeat sequences (PubMed:30874562).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||Sterol 14-alpha demethylase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (PubMed:20955812). CYP51B encodes the enzyme primarily responsible for eburicol 14-alpha-demethylation, and plays an essential role in ascospore formation (PubMed:20955812). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable). http://togogenome.org/gene/229533:FGSG_04704 ^@ http://purl.uniprot.org/uniprot/I1RLB7 ^@ Similarity ^@ Belongs to the polysaccharide monooxygenase AA13 family. http://togogenome.org/gene/229533:FGSG_09109 ^@ http://purl.uniprot.org/uniprot/I1RXN5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_05519 ^@ http://purl.uniprot.org/uniprot/Q4IB89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with DNA double-strand breaks.|||Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).|||telomere http://togogenome.org/gene/229533:FGSG_09764 ^@ http://purl.uniprot.org/uniprot/I1RZD0 ^@ Function|||Induction|||Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.|||Phosphomevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). ERG8 converts 5-phosphomevalonate to 5-diphosphomevalonate (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. Activity by the mevalonate kinase ERG12 (FG05912) first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (FG09764). The diphosphomevalonate decarboxylase ERG19 (FG10424) then produces isopentenyl diphosphate. The isopentenyl-diphosphate delta-isomerase IDI1 (FG09722) then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP). Finally the farnesyl diphosphate synthase ERG20 (FG06784) catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (Probable). http://togogenome.org/gene/229533:FGSG_02022 ^@ http://purl.uniprot.org/uniprot/I1RED5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/229533:FGSG_07946 ^@ http://purl.uniprot.org/uniprot/I1RUP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/229533:FGSG_13041 ^@ http://purl.uniprot.org/uniprot/I1S863 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_10639 ^@ http://purl.uniprot.org/uniprot/I1S1N1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08351 ^@ http://purl.uniprot.org/uniprot/V6RM02 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/229533:FGSG_06675 ^@ http://purl.uniprot.org/uniprot/I1RRF5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Homodimer. http://togogenome.org/gene/229533:FGSG_01622 ^@ http://purl.uniprot.org/uniprot/I1RDC8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/229533:FGSG_07441 ^@ http://purl.uniprot.org/uniprot/I1RTD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BIG1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_02675 ^@ http://purl.uniprot.org/uniprot/I1RG26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08595 ^@ http://purl.uniprot.org/uniprot/I1RWD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_02622 ^@ http://purl.uniprot.org/uniprot/I1RFX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05029 ^@ http://purl.uniprot.org/uniprot/A0A1I9FSH1|||http://purl.uniprot.org/uniprot/Q4ICM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PAM17 family.|||Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Component of the PAM complex, at least composed of mtHsp70 (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18.|||Component of the PAM complex.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10164 ^@ http://purl.uniprot.org/uniprot/I1S0E0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_08341 ^@ http://purl.uniprot.org/uniprot/I1RVQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06051 ^@ http://purl.uniprot.org/uniprot/I1RPS2 ^@ Similarity ^@ Belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/229533:FGSG_05725 ^@ http://purl.uniprot.org/uniprot/I1RNY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06133 ^@ http://purl.uniprot.org/uniprot/I1RQ01 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/229533:FGSG_00946 ^@ http://purl.uniprot.org/uniprot/I1RBL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05683 ^@ http://purl.uniprot.org/uniprot/I1RNU3 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/229533:FGSG_02563 ^@ http://purl.uniprot.org/uniprot/I1RFS5 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/229533:FGSG_01638 ^@ http://purl.uniprot.org/uniprot/I1RDE2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02179 ^@ http://purl.uniprot.org/uniprot/I1RES8 ^@ Function|||Similarity ^@ Belongs to the MUB1/samB family.|||Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation. http://togogenome.org/gene/229533:FGSG_08676 ^@ http://purl.uniprot.org/uniprot/I1RWK3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/229533:FGSG_07363 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJP6|||http://purl.uniprot.org/uniprot/Q4I5Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CGR1 family.|||Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_01705 ^@ http://purl.uniprot.org/uniprot/I1RDK3 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily. http://togogenome.org/gene/229533:FGSG_13956 ^@ http://purl.uniprot.org/uniprot/I1SAS5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. http://togogenome.org/gene/229533:FGSG_08022 ^@ http://purl.uniprot.org/uniprot/I1RUW4 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_11845 ^@ http://purl.uniprot.org/uniprot/I1S4S7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/229533:FGSG_00404 ^@ http://purl.uniprot.org/uniprot/I1RA77 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06294 ^@ http://purl.uniprot.org/uniprot/I1RQF2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/229533:FGSG_10272 ^@ http://purl.uniprot.org/uniprot/I1S0N8 ^@ Similarity ^@ Belongs to the RSP5/NEDD4 family. http://togogenome.org/gene/229533:FGSG_07339 ^@ http://purl.uniprot.org/uniprot/I1RT45 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_13189 ^@ http://purl.uniprot.org/uniprot/I1S8L1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_05769 ^@ http://purl.uniprot.org/uniprot/I1RP20 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/229533:FGSG_00787 ^@ http://purl.uniprot.org/uniprot/I1RB80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05728 ^@ http://purl.uniprot.org/uniprot/I1RNY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_01699 ^@ http://purl.uniprot.org/uniprot/I1RDJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/229533:FGSG_05558 ^@ http://purl.uniprot.org/uniprot/Q4IB50 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.|||Chromosome|||Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.|||Nucleus|||The AWS and SET domains are necessary for transcription repression. http://togogenome.org/gene/229533:FGSG_03260 ^@ http://purl.uniprot.org/uniprot/I1RHK3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_04254 ^@ http://purl.uniprot.org/uniprot/A0A1I9FFX3|||http://purl.uniprot.org/uniprot/Q4IEV4 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation at Lys-316 is required for proper function.|||Belongs to the MYST (SAS/MOZ) family.|||Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).|||Chromosome|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus|||The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity. http://togogenome.org/gene/229533:FGSG_01028 ^@ http://purl.uniprot.org/uniprot/I1RBT8 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/229533:FGSG_07442 ^@ http://purl.uniprot.org/uniprot/I1RTD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_09896 ^@ http://purl.uniprot.org/uniprot/A0A1I9F3T1|||http://purl.uniprot.org/uniprot/Q4HYR2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion.|||Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.|||Glyoxysome|||Homotetramer. http://togogenome.org/gene/229533:FGSG_12264 ^@ http://purl.uniprot.org/uniprot/I1S5Z3 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/229533:FGSG_06110 ^@ http://purl.uniprot.org/uniprot/I1RPX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_02874 ^@ http://purl.uniprot.org/uniprot/I1RGK4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07351 ^@ http://purl.uniprot.org/uniprot/I1RT54 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/229533:FGSG_03069 ^@ http://purl.uniprot.org/uniprot/I1RH30 ^@ Similarity ^@ Belongs to the DapA family. http://togogenome.org/gene/229533:FGSG_07342 ^@ http://purl.uniprot.org/uniprot/I1RT47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06516 ^@ http://purl.uniprot.org/uniprot/I1RR13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00276 ^@ http://purl.uniprot.org/uniprot/I1R9W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPDU1 (TC 2.A.43.3) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02327 ^@ http://purl.uniprot.org/uniprot/I1RF61 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FMO family.|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).|||Impairs autofusarin biosynthesis and leads to a yellow pigmentation via accumulation of the intermediate rubrofusarin (PubMed:16879655).|||Might be part of an extracellular enzyme complex composed of GIP1, aurF, aurO and aurS (PubMed:21296881).|||Monooxygenase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881).|||Secreted|||extracellular space http://togogenome.org/gene/229533:FGSG_07884 ^@ http://purl.uniprot.org/uniprot/I1RUJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05087 ^@ http://purl.uniprot.org/uniprot/I1RMA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Homotetramer.|||Mitochondrial acetyl-CoA acetyltransferase that catalyzes both the formation and degradation of acetoacetyl-CoA (By similarity). Seems not to be involved in ergosterol biosynthesis (By similarity). Plays an important role in growth, morphogenesis and maintaining mitochondrial function including the response to oxidative stresses (By similarity).|||Mitochondrion http://togogenome.org/gene/229533:FGSG_05483 ^@ http://purl.uniprot.org/uniprot/I1RNB5 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_05250 ^@ http://purl.uniprot.org/uniprot/I1RMQ5 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/229533:FGSG_09801 ^@ http://purl.uniprot.org/uniprot/I1RZG1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/229533:FGSG_02702 ^@ http://purl.uniprot.org/uniprot/I1RG53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. http://togogenome.org/gene/229533:FGSG_06289 ^@ http://purl.uniprot.org/uniprot/I1RQE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/229533:FGSG_10780 ^@ http://purl.uniprot.org/uniprot/I1S200 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/229533:FGSG_04666 ^@ http://purl.uniprot.org/uniprot/I1RL82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08669 ^@ http://purl.uniprot.org/uniprot/I1RWJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_07289 ^@ http://purl.uniprot.org/uniprot/I1RT01 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/229533:FGSG_06372 ^@ http://purl.uniprot.org/uniprot/I1RQM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/229533:FGSG_09766 ^@ http://purl.uniprot.org/uniprot/A0A1I9FKD0|||http://purl.uniprot.org/uniprot/Q4HZ42 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_10743 ^@ http://purl.uniprot.org/uniprot/I1S1W8 ^@ Similarity ^@ In the C-terminal section; belongs to the TrpB family.|||In the N-terminal section; belongs to the TrpA family. http://togogenome.org/gene/229533:FGSG_10796 ^@ http://purl.uniprot.org/uniprot/I1S215 ^@ Similarity ^@ Belongs to the MIT1/WOR1 family. http://togogenome.org/gene/229533:FGSG_12489 ^@ http://purl.uniprot.org/uniprot/I1S6L7 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_08597 ^@ http://purl.uniprot.org/uniprot/I1RWD3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/229533:FGSG_01141 ^@ http://purl.uniprot.org/uniprot/I1RC39 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_08375 ^@ http://purl.uniprot.org/uniprot/I1RVT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06914 ^@ http://purl.uniprot.org/uniprot/I1RS10 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/229533:FGSG_00271 ^@ http://purl.uniprot.org/uniprot/A0A1I9EUS9|||http://purl.uniprot.org/uniprot/Q4IR87 ^@ Caution|||Similarity ^@ Although strongly related to the peptide:N-glycanase enzyme, it lacks the conserved active site Cys in position 243, which is replaced by a Val residue suggesting that it has no activity.|||Belongs to the transglutaminase-like superfamily. PNGase family. http://togogenome.org/gene/229533:FGSG_02624 ^@ http://purl.uniprot.org/uniprot/I1RFY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NifU family.|||Mitochondrion matrix|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/229533:FGSG_03878 ^@ http://purl.uniprot.org/uniprot/I1RJ71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01091 ^@ http://purl.uniprot.org/uniprot/I1RBZ3 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/229533:FGSG_08047 ^@ http://purl.uniprot.org/uniprot/I1RUY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00877 ^@ http://purl.uniprot.org/uniprot/A0A1I9EX09|||http://purl.uniprot.org/uniprot/Q4IPI1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.|||Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_11042 ^@ http://purl.uniprot.org/uniprot/I1S2P2 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/229533:FGSG_03869 ^@ http://purl.uniprot.org/uniprot/I1RJ65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10952 ^@ http://purl.uniprot.org/uniprot/I1S2F9 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/229533:FGSG_07547 ^@ http://purl.uniprot.org/uniprot/A0A1I9FR99|||http://purl.uniprot.org/uniprot/Q4I5G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Belongs to the ubiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/229533:FGSG_08995 ^@ http://purl.uniprot.org/uniprot/I1RXC9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_13084 ^@ http://purl.uniprot.org/uniprot/I1S8A6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_10234 ^@ http://purl.uniprot.org/uniprot/I1S0K5 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/229533:FGSG_06863 ^@ http://purl.uniprot.org/uniprot/V6REG9 ^@ Function|||Similarity ^@ Belongs to the Dus family. Dus3 subfamily.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation. http://togogenome.org/gene/229533:FGSG_05858 ^@ http://purl.uniprot.org/uniprot/A0A1I9FU53|||http://purl.uniprot.org/uniprot/Q4IAA0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_09838 ^@ http://purl.uniprot.org/uniprot/I1RZJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC6 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/229533:FGSG_11628 ^@ http://purl.uniprot.org/uniprot/I1S464 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I LYR family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_02384 ^@ http://purl.uniprot.org/uniprot/I1RFB5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03666 ^@ http://purl.uniprot.org/uniprot/I1RIM6 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_00034 ^@ http://purl.uniprot.org/uniprot/I1R9A5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_04072 ^@ http://purl.uniprot.org/uniprot/I1RJP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMA20 family.|||Cytoplasm|||Involved in translation. http://togogenome.org/gene/229533:FGSG_10868 ^@ http://purl.uniprot.org/uniprot/I1S282 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01152 ^@ http://purl.uniprot.org/uniprot/I1RC49 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/229533:FGSG_05933 ^@ http://purl.uniprot.org/uniprot/I1RPG4 ^@ Similarity ^@ Belongs to the SurE nucleotidase family. http://togogenome.org/gene/229533:FGSG_08478 ^@ http://purl.uniprot.org/uniprot/I1RW25 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/229533:FGSG_08221 ^@ http://purl.uniprot.org/uniprot/I1RVE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07320 ^@ http://purl.uniprot.org/uniprot/I1RT28 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/229533:FGSG_03246 ^@ http://purl.uniprot.org/uniprot/I1RHJ0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01196 ^@ http://purl.uniprot.org/uniprot/I1RC93 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_10236 ^@ http://purl.uniprot.org/uniprot/V6RQR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha. http://togogenome.org/gene/229533:FGSG_11782 ^@ http://purl.uniprot.org/uniprot/I1S4L4 ^@ Similarity ^@ Belongs to the MYBBP1A family. http://togogenome.org/gene/229533:FGSG_08209 ^@ http://purl.uniprot.org/uniprot/I1RVD9 ^@ Disruption Phenotype|||Domain|||Function|||Similarity ^@ Belongs to the NRP synthetase family.|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase (By similarity). NRPS7 has the following architecture: C-A-T-C-A-T-C-A-T-Cy. The last condensation domain (Cy) could be responsible for cyclization of the final product (Probable).|||Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the lipopeptide fusaristatin A (PubMed:25412204). Fusaristatin A consists of a polyketide chain linked to three amino acid residues glutamine (Gln), dehydroalanine (dehydro-Ala), and beta-aminoisobutyric acid (PubMed:25412204). The biosynthesis starts with formation of a linear polyketide chain by the highly reducing polyketide synthase PKS6 (PubMed:25412204). The gene cluster does not contain an acyl-CoA ligase or an acyl-transferase, and it is therefore predicted that the polyketide is transferred directly to the nonribosomal peptide synthetase NRPS7 (Probable). Modules 1-3 from NRPS7 incorporate dehydro-Ala, Gln, and beta-aminoisobutyric acid in the compound, which is released by cyclization (PubMed:25412204). The beta-aminoisobutyric acid units are most likely not freely available to the NRPS, but can be synthesized from thymine, which requires a dehydrogenase, a monooxygenase, and an aminotransferase. The fusaristatin A cluster contains a cytochrome P450 monooxygenase (FGSG_08207) and an aminotransferase (FGSG_17085), which theoretically can perform two of the enzymatic steps (Probable). The enzymes may however also be involved in biosynthesis of dehydroalanine or modification of the polyketide (Probable). The dehydro-Ala residue can be a result of cyclization, where serine is dehydrated (Probable). The last gene of the cluster encodes a protein with an A/B barrel domain found in variable enzymes, which hampers functional prediction (Probable).|||impairs the production of fusaristatin A. http://togogenome.org/gene/229533:FGSG_06350 ^@ http://purl.uniprot.org/uniprot/I1RQK5 ^@ Subunit ^@ Component of the ESCRT-0 complex composed of HSE1 and VPS27. http://togogenome.org/gene/229533:FGSG_02383 ^@ http://purl.uniprot.org/uniprot/I1RFB4 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/229533:FGSG_06731 ^@ http://purl.uniprot.org/uniprot/I1RRK4 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/229533:FGSG_11475 ^@ http://purl.uniprot.org/uniprot/I1S3S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09735 ^@ http://purl.uniprot.org/uniprot/V6RQ48 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/229533:FGSG_02202 ^@ http://purl.uniprot.org/uniprot/I1REU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_04906 ^@ http://purl.uniprot.org/uniprot/I1RLT7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LIMR family. LMBRD1 subfamily.|||Lysosome membrane|||Probable lysosomal cobalamin transporter. Required to export cobalamin from lysosomes allowing its conversion to cofactors. http://togogenome.org/gene/229533:FGSG_01386 ^@ http://purl.uniprot.org/uniprot/V6QYF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/229533:FGSG_03002 ^@ http://purl.uniprot.org/uniprot/I1RGX1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_10895 ^@ http://purl.uniprot.org/uniprot/I1S2A9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08480 ^@ http://purl.uniprot.org/uniprot/I1RW27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA1 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_02054 ^@ http://purl.uniprot.org/uniprot/I1REG6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/229533:FGSG_11293 ^@ http://purl.uniprot.org/uniprot/I1S3B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00796 ^@ http://purl.uniprot.org/uniprot/I1RB87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XLF subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_06282 ^@ http://purl.uniprot.org/uniprot/I1RQE1 ^@ Similarity ^@ Belongs to the acetolactate synthase small subunit family. http://togogenome.org/gene/229533:FGSG_09980 ^@ http://purl.uniprot.org/uniprot/I1RZX4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/229533:FGSG_12518 ^@ http://purl.uniprot.org/uniprot/I1S6P5 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/229533:FGSG_08230 ^@ http://purl.uniprot.org/uniprot/I1RVF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01739 ^@ http://purl.uniprot.org/uniprot/I1RDM9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_02943 ^@ http://purl.uniprot.org/uniprot/I1RGR9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_13993 ^@ http://purl.uniprot.org/uniprot/I1SAW2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07632 ^@ http://purl.uniprot.org/uniprot/I1RTW4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08079 ^@ http://purl.uniprot.org/uniprot/I1RV19 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Cytochrome P450 monooxygenase FG08079; part of the gene cluster that mediates the biosynthesis of butenolide, a mycotoxin that shows antibiotic activity but does not seem to play a major role in the spread of head blight in wheat (PubMed:17175185). Butenolide is derived from glutamic acid via a 4-acetamido-2-butenoic acid intermediate (Probable). The predicted function of the NADH:flavin oxidoreductase FG08077, the cytochrome P450 monooxygenase FG08079, the decarboxylase FG08083, and the putative acetyltransferase FG08082 are consistent with this pathway, however, the respective activities of the butelonide biosynthesis cluster enzymes have still to be experimentally determined (Probable).|||Highly expressed under trichothecene-producing conditions.|||Membrane|||Results in the loss of butelonide production. http://togogenome.org/gene/229533:FGSG_10036 ^@ http://purl.uniprot.org/uniprot/I1S024 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/229533:FGSG_09509 ^@ http://purl.uniprot.org/uniprot/I1RYQ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Binds 1 [4Fe-4S] cluster.|||Chromosome|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Nucleus http://togogenome.org/gene/229533:FGSG_10935 ^@ http://purl.uniprot.org/uniprot/I1S2E3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10587 ^@ http://purl.uniprot.org/uniprot/I1S1I3 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/229533:FGSG_07358 ^@ http://purl.uniprot.org/uniprot/I1RT61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S9B family.|||Membrane|||Type IV dipeptidyl-peptidase which removes N-terminal dipeptides sequentially from polypeptides having unsubstituted N-termini provided that the penultimate residue is proline.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07951 ^@ http://purl.uniprot.org/uniprot/I1RUQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAM1 family.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_06320 ^@ http://purl.uniprot.org/uniprot/I1RQH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN).|||Belongs to the VPS51 family.|||Component of the Golgi-associated retrograde protein (GARP) complex.|||trans-Golgi network http://togogenome.org/gene/229533:FGSG_04862 ^@ http://purl.uniprot.org/uniprot/I1RLP8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_11843 ^@ http://purl.uniprot.org/uniprot/I1S4S5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07421 ^@ http://purl.uniprot.org/uniprot/I1RTC0 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/229533:FGSG_01873 ^@ http://purl.uniprot.org/uniprot/V6QY25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASP family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/229533:FGSG_12840 ^@ http://purl.uniprot.org/uniprot/I1S7L7 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/229533:FGSG_05952 ^@ http://purl.uniprot.org/uniprot/I1RPI2 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/229533:FGSG_00744 ^@ http://purl.uniprot.org/uniprot/I1RB39 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/229533:FGSG_07484 ^@ http://purl.uniprot.org/uniprot/A0A1I9FH57|||http://purl.uniprot.org/uniprot/Q4I5M4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity).|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/229533:FGSG_01232 ^@ http://purl.uniprot.org/uniprot/I1RCC7 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/229533:FGSG_12878 ^@ http://purl.uniprot.org/uniprot/I1S7Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DDI1 family.|||Binds ubiquitin and polyubiquitinated proteins.|||Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. http://togogenome.org/gene/229533:FGSG_05955 ^@ http://purl.uniprot.org/uniprot/A0A1I9FV31|||http://purl.uniprot.org/uniprot/I1RPI4 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family.|||Catalyzes the final step in the biosynthesis of the membrane lipid glucosylceramide (GluCer), the transfer of glucose to ceramide (Probable). Glucosylceramides play important roles in growth, differentiation and pathogenicity. Contribution to fungal pathogenesis is host-dependent (PubMed:17908205).|||Golgi apparatus membrane|||Results in complete loss of glucosylceramides (GluCers) in mutant cells. Shows a significant change in the conidial morphology and displays a dramatic polar growth defect, and its mycelia are resistant to cell wall degrading enzymes. Shows increased resistance to plant defensins MsDef1 and RsAFP2, but not MsDef4.|||The D1, D2, D3, (Q/R)XXRW motif is a critical part of the GCS active site, involved in catalysis and UDP-sugar binding. http://togogenome.org/gene/229533:FGSG_01941 ^@ http://purl.uniprot.org/uniprot/I1RE65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08135 ^@ http://purl.uniprot.org/uniprot/I1RV71 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05478 ^@ http://purl.uniprot.org/uniprot/A0A1I9FUZ8|||http://purl.uniprot.org/uniprot/Q4IBD0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity).|||Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14. http://togogenome.org/gene/229533:FGSG_00087 ^@ http://purl.uniprot.org/uniprot/I1R9F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10856 ^@ http://purl.uniprot.org/uniprot/I1S270 ^@ Similarity ^@ Belongs to the actin family. ARP3 subfamily. http://togogenome.org/gene/229533:FGSG_06290 ^@ http://purl.uniprot.org/uniprot/I1RQE8 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/229533:FGSG_08773 ^@ http://purl.uniprot.org/uniprot/A0A1I9F9Y0|||http://purl.uniprot.org/uniprot/Q4I1Y5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transferase hexapeptide repeat family.|||Cytoplasm|||Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity).|||Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint. http://togogenome.org/gene/229533:FGSG_05277 ^@ http://purl.uniprot.org/uniprot/I1RMT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/229533:FGSG_04571 ^@ http://purl.uniprot.org/uniprot/I1RKZ8 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/229533:FGSG_09782 ^@ http://purl.uniprot.org/uniprot/I1RZE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_05665 ^@ http://purl.uniprot.org/uniprot/I1RNS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/229533:FGSG_07239 ^@ http://purl.uniprot.org/uniprot/I1RSV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/229533:FGSG_06963 ^@ http://purl.uniprot.org/uniprot/I1RS52 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/229533:FGSG_12126 ^@ http://purl.uniprot.org/uniprot/A0A098D8A0 ^@ Disruption Phenotype|||Function|||Induction ^@ Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:16262793). Conditions for carbon-, nitrogen-, or phosphorus-starvations lead to very low expression (PubMed:16262793). Increase in pH results in gradual reduction of the gene expression (PubMed:16262793).|||Highly reducing polyketide synthase; part of the gene cluster that mediates the biosynthesis of zearalenone (ZEA), a nonsteroid estrogen that is a contaminant of cereal grains and causes estrogenic disorders in humans and animals (PubMed:16262793, PubMed:16517624, PubMed:18427109). The ZEA backbone is synthesized from a single acetyl-CoA molecule and eight malonyl-CoA molecules (PubMed:16262793, PubMed:16517624, PubMed:18427109). The reducing polyketide synthase ZEA2 is proposed to synthesize a reduced hexaketide intermediate by using different combinations of its reductive domains during each round of condensation (PubMed:16262793, PubMed:16517624, PubMed:16751498, PubMed:18427109). The hexaketide thioester is then transacylated to the non-reducing polyketide synthase ZEA1 and is further condensed with three malonyl-CoAs without reductive tailoring to yield a mixed reduced/unreduced nonaketide (PubMed:16262793, PubMed:16517624, PubMed:18427109). ZEA1 must be able to interact with ZEA2 to facilitate starter-unit acyltransfer and initiate polyketide biosynthesis (PubMed:18427109). ZEA1 also mediates the required C2-C7 cyclization to form the resorcylate core and catalyzes the formation of the macrolactone (PubMed:18427109). ZEB1 is then responsible for the chemical conversion of beta-zearalenonol (beta-ZOL) to ZEA in the biosynthetic pathway (PubMed:16262793).|||Results in the loss of zearalenone production but still produces beta-zearalenonol (PubMed:16262793, PubMed:16517624, PubMed:16751498). http://togogenome.org/gene/229533:FGSG_10304 ^@ http://purl.uniprot.org/uniprot/I1S0R7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family. http://togogenome.org/gene/229533:FGSG_12955 ^@ http://purl.uniprot.org/uniprot/I1S7Y0 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/229533:FGSG_04137 ^@ http://purl.uniprot.org/uniprot/I1RJV4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/229533:FGSG_07798 ^@ http://purl.uniprot.org/uniprot/I1RUB2 ^@ Similarity ^@ In the C-terminal section; belongs to the NRP synthetase family. http://togogenome.org/gene/229533:FGSG_01795 ^@ http://purl.uniprot.org/uniprot/I1RDS9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06353 ^@ http://purl.uniprot.org/uniprot/I1RQK8 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/229533:FGSG_01369 ^@ http://purl.uniprot.org/uniprot/I1RCP5 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/229533:FGSG_07514 ^@ http://purl.uniprot.org/uniprot/I1RTK5 ^@ Similarity|||Subunit ^@ Belongs to the FBXO31 family.|||Part of a SCF (SKP1-cullin-F-box) protein ligase complex. http://togogenome.org/gene/229533:FGSG_00559 ^@ http://purl.uniprot.org/uniprot/I1RAM7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/229533:FGSG_09630 ^@ http://purl.uniprot.org/uniprot/I1RZ12 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_05195 ^@ http://purl.uniprot.org/uniprot/I1RMK4 ^@ Similarity ^@ In the C-terminal section; belongs to the anthranilate synthase component I family. http://togogenome.org/gene/229533:FGSG_04988 ^@ http://purl.uniprot.org/uniprot/I1RM14 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_07137 ^@ http://purl.uniprot.org/uniprot/I1RSL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07476 ^@ http://purl.uniprot.org/uniprot/I1RTH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/229533:FGSG_13456 ^@ http://purl.uniprot.org/uniprot/I1S9C6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09118 ^@ http://purl.uniprot.org/uniprot/I1RXP4 ^@ Caution|||Similarity ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_11163 ^@ http://purl.uniprot.org/uniprot/V6RU70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_05360 ^@ http://purl.uniprot.org/uniprot/I1RN04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_01538 ^@ http://purl.uniprot.org/uniprot/A0A1I9EZ89|||http://purl.uniprot.org/uniprot/Q4IMM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_09489 ^@ http://purl.uniprot.org/uniprot/I1RYN2 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/229533:FGSG_10283 ^@ http://purl.uniprot.org/uniprot/I1S0P7 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG2 family.|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Endoplasmic reticulum membrane|||Interacts with ATG18 (By similarity).|||Lipid transfer protein required for autophagosome completion and peroxisome degradation and peroxisome degradation (By similarity). Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion (By similarity). ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region (By similarity). The latter binding is assisted by an ATG18-PtdIns3P interaction (By similarity). ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Preautophagosomal structure membrane http://togogenome.org/gene/229533:FGSG_07173 ^@ http://purl.uniprot.org/uniprot/I1RSP5 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/229533:FGSG_09147 ^@ http://purl.uniprot.org/uniprot/I1RXS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06048 ^@ http://purl.uniprot.org/uniprot/I1RPR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/229533:FGSG_02111 ^@ http://purl.uniprot.org/uniprot/I1REL9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09760 ^@ http://purl.uniprot.org/uniprot/I1RZC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_10942 ^@ http://purl.uniprot.org/uniprot/I1S2F0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/229533:FGSG_05494 ^@ http://purl.uniprot.org/uniprot/I1RNC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_00328 ^@ http://purl.uniprot.org/uniprot/I1RA11 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/229533:FGSG_08627 ^@ http://purl.uniprot.org/uniprot/I1RWF9 ^@ Function|||Similarity ^@ Belongs to the flavokinase family.|||Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme. http://togogenome.org/gene/229533:FGSG_05619 ^@ http://purl.uniprot.org/uniprot/I1RNN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/229533:FGSG_00777 ^@ http://purl.uniprot.org/uniprot/I1RB70 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_08321 ^@ http://purl.uniprot.org/uniprot/I1RVN8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_07086 ^@ http://purl.uniprot.org/uniprot/I1RSG8 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/229533:FGSG_09206 ^@ http://purl.uniprot.org/uniprot/V6RMS3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion.|||Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_01243 ^@ http://purl.uniprot.org/uniprot/V6QW25 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/229533:FGSG_01388 ^@ http://purl.uniprot.org/uniprot/I1RCR2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/229533:FGSG_11847 ^@ http://purl.uniprot.org/uniprot/I1S4S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06551 ^@ http://purl.uniprot.org/uniprot/I1RR42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09661 ^@ http://purl.uniprot.org/uniprot/I1RZ38 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/229533:FGSG_04829 ^@ http://purl.uniprot.org/uniprot/I1RLM3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_06120 ^@ http://purl.uniprot.org/uniprot/I1RPY8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10262 ^@ http://purl.uniprot.org/uniprot/I1S0M9 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/229533:FGSG_04273 ^@ http://purl.uniprot.org/uniprot/I1RK79 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/229533:FGSG_11988 ^@ http://purl.uniprot.org/uniprot/I1S570 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00352 ^@ http://purl.uniprot.org/uniprot/I1RA31 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/229533:FGSG_06903 ^@ http://purl.uniprot.org/uniprot/I1RRZ9 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/229533:FGSG_01150 ^@ http://purl.uniprot.org/uniprot/I1RC47 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endopolyphosphatase PPN1 family.|||Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_00799 ^@ http://purl.uniprot.org/uniprot/I1RB89 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX4 family.|||Forms a heterodimer with SLX1.|||Nucleus|||Phosphorylated in response to DNA damage.|||Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA. http://togogenome.org/gene/229533:FGSG_13370 ^@ http://purl.uniprot.org/uniprot/A0A1I9F833|||http://purl.uniprot.org/uniprot/Q4I2X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. http://togogenome.org/gene/229533:FGSG_11011 ^@ http://purl.uniprot.org/uniprot/I1S2L3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_08044 ^@ http://purl.uniprot.org/uniprot/I1RUY5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/229533:FGSG_08407 ^@ http://purl.uniprot.org/uniprot/I1RVW1 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_05539 ^@ http://purl.uniprot.org/uniprot/I1RNG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04146 ^@ http://purl.uniprot.org/uniprot/I1RJW3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00663 ^@ http://purl.uniprot.org/uniprot/I1RAW9 ^@ Function|||Similarity|||Subunit ^@ Associates with the respiratory chain complex III/complex IV supercomplex.|||Belongs to the RCF1 family.|||Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes. http://togogenome.org/gene/229533:FGSG_03767 ^@ http://purl.uniprot.org/uniprot/I1RIX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/229533:FGSG_10308 ^@ http://purl.uniprot.org/uniprot/I1S0S1 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/229533:FGSG_08382 ^@ http://purl.uniprot.org/uniprot/I1RVT8 ^@ Similarity ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. http://togogenome.org/gene/229533:FGSG_11066 ^@ http://purl.uniprot.org/uniprot/I1S2R5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_00863 ^@ http://purl.uniprot.org/uniprot/I1RBE6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/229533:FGSG_09218 ^@ http://purl.uniprot.org/uniprot/I1RXZ1 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/229533:FGSG_03535 ^@ http://purl.uniprot.org/uniprot/I1RIA5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_07866 ^@ http://purl.uniprot.org/uniprot/I1RUH3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_11367 ^@ http://purl.uniprot.org/uniprot/I1S3I3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_09704 ^@ http://purl.uniprot.org/uniprot/I1RZ78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/229533:FGSG_02676 ^@ http://purl.uniprot.org/uniprot/I1RG27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08489 ^@ http://purl.uniprot.org/uniprot/I1RW35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10306 ^@ http://purl.uniprot.org/uniprot/I1S0R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00051 ^@ http://purl.uniprot.org/uniprot/I1R9B8 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family. http://togogenome.org/gene/229533:FGSG_10242 ^@ http://purl.uniprot.org/uniprot/V6RY33 ^@ Similarity|||Subunit ^@ Associated with the spliceosome.|||Belongs to the crooked-neck family. http://togogenome.org/gene/229533:FGSG_06178 ^@ http://purl.uniprot.org/uniprot/I1RQ42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_00621 ^@ http://purl.uniprot.org/uniprot/I1RAT5 ^@ Similarity ^@ Belongs to the DNA polymerase type-X family. http://togogenome.org/gene/229533:FGSG_09990 ^@ http://purl.uniprot.org/uniprot/I1RZY0 ^@ Function|||Similarity ^@ Belongs to the endosulfine family.|||Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. http://togogenome.org/gene/229533:FGSG_08784 ^@ http://purl.uniprot.org/uniprot/I1RWU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/229533:FGSG_09890 ^@ http://purl.uniprot.org/uniprot/I1RZP0 ^@ Similarity|||Subunit ^@ Belongs to the transthyretin family. 5-hydroxyisourate hydrolase subfamily.|||Homotetramer. http://togogenome.org/gene/229533:FGSG_03233 ^@ http://purl.uniprot.org/uniprot/I1RHH9 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_09839 ^@ http://purl.uniprot.org/uniprot/I1RZJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_11806 ^@ http://purl.uniprot.org/uniprot/I1S4N8 ^@ Function|||Similarity ^@ Belongs to the MUB1/samB family.|||Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation. http://togogenome.org/gene/229533:FGSG_02034 ^@ http://purl.uniprot.org/uniprot/I1REE6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_10158 ^@ http://purl.uniprot.org/uniprot/I1S0D5 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/229533:FGSG_00283 ^@ http://purl.uniprot.org/uniprot/I1R9W9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01351 ^@ http://purl.uniprot.org/uniprot/I1RCN0 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/229533:FGSG_02322 ^@ http://purl.uniprot.org/uniprot/I1RF56 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. TCR/Tet family.|||Cell membrane|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).|||Leads to pink mycelia in young cultures which turn red in older cultures, suggesting a delayed production of aurofusarin (PubMed:21296881).|||Rubrofusarin-specific efflux pump; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881). http://togogenome.org/gene/229533:FGSG_06442 ^@ http://purl.uniprot.org/uniprot/I1RQU2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06771 ^@ http://purl.uniprot.org/uniprot/I1RRN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06579 ^@ http://purl.uniprot.org/uniprot/I1RR67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the arsenical resistance-3 (ACR3) (TC 2.A.59) family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_03920 ^@ http://purl.uniprot.org/uniprot/I1RJB1 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_01123 ^@ http://purl.uniprot.org/uniprot/I1RC22 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/229533:FGSG_04902 ^@ http://purl.uniprot.org/uniprot/I1RLT3 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/229533:FGSG_07172 ^@ http://purl.uniprot.org/uniprot/I1RSP4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/229533:FGSG_06060 ^@ http://purl.uniprot.org/uniprot/I1RPT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02266 ^@ http://purl.uniprot.org/uniprot/I1RF04 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_00092 ^@ http://purl.uniprot.org/uniprot/I1R9F4 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_03027 ^@ http://purl.uniprot.org/uniprot/I1RGZ4 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/229533:FGSG_01036 ^@ http://purl.uniprot.org/uniprot/I1RBU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08093 ^@ http://purl.uniprot.org/uniprot/I1RV31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09846 ^@ http://purl.uniprot.org/uniprot/I1RZJ9 ^@ Similarity ^@ Belongs to the VAC14 family. http://togogenome.org/gene/229533:FGSG_11150 ^@ http://purl.uniprot.org/uniprot/V6RU86 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_05600 ^@ http://purl.uniprot.org/uniprot/I1RNL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_02671 ^@ http://purl.uniprot.org/uniprot/I1RG22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01642 ^@ http://purl.uniprot.org/uniprot/I1RDE6 ^@ Function|||Similarity ^@ Belongs to the LplA family.|||Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/229533:FGSG_04431 ^@ http://purl.uniprot.org/uniprot/I1RKM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09543 ^@ http://purl.uniprot.org/uniprot/I1RYT4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02212 ^@ http://purl.uniprot.org/uniprot/I1REV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03126 ^@ http://purl.uniprot.org/uniprot/I1RH81 ^@ Similarity ^@ Belongs to the tpcK family. http://togogenome.org/gene/229533:FGSG_04404 ^@ http://purl.uniprot.org/uniprot/I1RKJ6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_02059 ^@ http://purl.uniprot.org/uniprot/I1REH0 ^@ Function|||Similarity ^@ Belongs to the glycosyl hydrolase 27 family.|||Hydrolyzes a variety of simple alpha-D-galactoside as well as more complex molecules such as oligosaccharides and polysaccharides. http://togogenome.org/gene/229533:FGSG_06845 ^@ http://purl.uniprot.org/uniprot/V6REZ4 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/229533:FGSG_00762 ^@ http://purl.uniprot.org/uniprot/I1RB55 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_07032 ^@ http://purl.uniprot.org/uniprot/I1RSB8 ^@ Function|||Similarity ^@ Belongs to the MUB1/samB family.|||Involved in determination of the onset of polarized growth and morphogenesis. Plays a role in the regulation of branching in hyphae and spore formation. http://togogenome.org/gene/229533:FGSG_00865 ^@ http://purl.uniprot.org/uniprot/I1RBE7 ^@ Similarity ^@ In the C-terminal section; belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_06670 ^@ http://purl.uniprot.org/uniprot/I1RRF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus|||Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. http://togogenome.org/gene/229533:FGSG_07956 ^@ http://purl.uniprot.org/uniprot/I1RUQ5 ^@ Similarity ^@ Belongs to the proteasome subunit S11 family. http://togogenome.org/gene/229533:FGSG_10098 ^@ http://purl.uniprot.org/uniprot/I1S080 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05543 ^@ http://purl.uniprot.org/uniprot/A0A1I9FXS9|||http://purl.uniprot.org/uniprot/Q4IB65 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/229533:FGSG_01564 ^@ http://purl.uniprot.org/uniprot/I1RD74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01607 ^@ http://purl.uniprot.org/uniprot/I1RDB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_03906 ^@ http://purl.uniprot.org/uniprot/I1RJ98 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_01381 ^@ http://purl.uniprot.org/uniprot/I1RCQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_02326 ^@ http://purl.uniprot.org/uniprot/I1RF60 ^@ Function|||Induction|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-independent O-methyltransferase family. COMT subfamily.|||Expression is regulated by the aurofusarin biosynthesis cluster-specific transcription factor aurR1/GIP2 (PubMed:16879655, PubMed:16461721).|||O-methyltransferase; part of the gene cluster that mediates the biosynthesis of aurofusarin, a red mycelium pigment which is acting as a mycotoxin (PubMed:15811992, PubMed:15809006, PubMed:16879655). The first step is performed by the polyketide synthase which condenses one acetyl-CoA and 6 malonyl-CoA units to form the first intermediate, the cyclic heptaketide and yellow pigment YWA1 (PubMed:21296881, PubMed:23557488). The C2 hydroxyl group in the pyrone ring of YWA1 is probably formed during ring closure by an aldol-type cyclization reaction (PubMed:21296881). The dehydratase aurZ then acts as the first tailoring enzyme in the aurofusarin biosynthetic pathway by converting YWA1 to nor-rubrofusarin (PubMed:21296881, PubMed:23557488). Nor-rubrofusarin is then methylated to rubrofusarin by the O-methyltransferase aurJ (PubMed:21296881, PubMed:23557488). Rubrofusarin is then transported across the plasma membrane by the rubrofusarin-specific pump aurT for further enzymatic processing by the extracellular complex composed of GIP1, aurF, aurO and aurS to yield aurofusarin (PubMed:21296881). http://togogenome.org/gene/229533:FGSG_03213 ^@ http://purl.uniprot.org/uniprot/I1RHG1 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_12669 ^@ http://purl.uniprot.org/uniprot/I1S746 ^@ Similarity ^@ Belongs to the ACC deaminase/D-cysteine desulfhydrase family. http://togogenome.org/gene/229533:FGSG_06149 ^@ http://purl.uniprot.org/uniprot/I1RQ16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_00176 ^@ http://purl.uniprot.org/uniprot/I1R9M7 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion. http://togogenome.org/gene/229533:FGSG_05114 ^@ http://purl.uniprot.org/uniprot/I1RMC5 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/229533:FGSG_01032 ^@ http://purl.uniprot.org/uniprot/I1RBU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_10525 ^@ http://purl.uniprot.org/uniprot/I1S1C5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/229533:FGSG_02069 ^@ http://purl.uniprot.org/uniprot/I1REI0 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/229533:FGSG_06689 ^@ http://purl.uniprot.org/uniprot/I1RRG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_07604 ^@ http://purl.uniprot.org/uniprot/I1RTT8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10490 ^@ http://purl.uniprot.org/uniprot/I1S190 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01030 ^@ http://purl.uniprot.org/uniprot/I1RBU0 ^@ Similarity ^@ Belongs to the CDC6/cdc18 family. http://togogenome.org/gene/229533:FGSG_05091 ^@ http://purl.uniprot.org/uniprot/I1RMA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04570 ^@ http://purl.uniprot.org/uniprot/I1RKZ7 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_01499 ^@ http://purl.uniprot.org/uniprot/I1RD12 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01963 ^@ http://purl.uniprot.org/uniprot/I1RE83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/229533:FGSG_05221 ^@ http://purl.uniprot.org/uniprot/I1RMM8 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/229533:FGSG_02566 ^@ http://purl.uniprot.org/uniprot/I1RFS8 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG16 family.|||Does not significantly decrease the growth rate under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236). Reduces also strongly the production of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Homodimer (By similarity). Part of the ATG5-ATG12/ATG16 complex (By similarity). Several units of each may be present in this complex (By similarity). Interacts directly with ATG12 (By similarity).|||Preautophagosomal structure membrane|||Stabilizes the ATG5-ATG12 conjugate (By similarity). The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS) (By similarity). Recruits also ATG3 to the PAS (By similarity). Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236). http://togogenome.org/gene/229533:FGSG_02482 ^@ http://purl.uniprot.org/uniprot/I1RFK3 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/229533:FGSG_07016 ^@ http://purl.uniprot.org/uniprot/I1RSA2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/229533:FGSG_10422 ^@ http://purl.uniprot.org/uniprot/I1S128 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_09844 ^@ http://purl.uniprot.org/uniprot/I1RZJ7 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/229533:FGSG_06640 ^@ http://purl.uniprot.org/uniprot/I1RRC2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/229533:FGSG_08942 ^@ http://purl.uniprot.org/uniprot/V6RK40 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_03579 ^@ http://purl.uniprot.org/uniprot/I1RIE7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_06530 ^@ http://purl.uniprot.org/uniprot/I1RR24 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/229533:FGSG_07192 ^@ http://purl.uniprot.org/uniprot/I1RSR1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08455 ^@ http://purl.uniprot.org/uniprot/I1RW03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02790 ^@ http://purl.uniprot.org/uniprot/I1RGD1 ^@ Similarity ^@ Belongs to the WD repeat MET30/SCONB/SCON-2 family. http://togogenome.org/gene/229533:FGSG_10174 ^@ http://purl.uniprot.org/uniprot/I1S0F0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10007 ^@ http://purl.uniprot.org/uniprot/I1RZZ6 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Endosome membrane|||Golgi apparatus membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||The C2 domains have an essential, but non-catalytic function. They may facilitate interactions with other proteins and are required for lipid transport function. http://togogenome.org/gene/229533:FGSG_03735 ^@ http://purl.uniprot.org/uniprot/I1RIU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_05954 ^@ http://purl.uniprot.org/uniprot/I1RPI3 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/229533:FGSG_09505 ^@ http://purl.uniprot.org/uniprot/I1RYP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP18 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Membrane http://togogenome.org/gene/229533:FGSG_11395 ^@ http://purl.uniprot.org/uniprot/I1S3K7 ^@ Disruption Phenotype|||Domain|||Function|||Induction|||Similarity ^@ Belongs to the NRP synthetase family.|||Expression is induced during the infection of wheat and barley.|||Impairs the production of chrysogine.|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, epimerase (E) domains (responsible for L- to D-amino acid conversion) are present within the NRP synthetase. VerP has the following architecture: A-T-C-A-T-C.|||Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the yellow pigment chrysogine (PubMed:28708398). Pyruvic acid and anthranilic acid are likely substrates for the nonribosomal peptide synthetase chry1/NRPS14, with pyruvic acid adenylated by the first A domain and anthranilic acid by the second (Probable). If pyruvic acid and anthranilic acid are merged and released from chry1/NRPS14 by hydrolysis, a subsequent amidation would lead to 2-pyruvoylaminobenzamide (Probable). This process is probably catalyzed by the amidotransferase chry2 using glutamine as amino donor (Probable). The dehydrogenase chry5 that has a terminal berberine bridge domain for C-N cyclization could catalyze the cyclization of 2-pyruvoylaminobenzamide to yield acetyl-4(3H)-quinazolidinone (Probable). A final reduction of acetyl-4(3H)-quinazolidinone catalyzed by the oxidoreductase chry4 would result in chrysogine (Probable). http://togogenome.org/gene/229533:FGSG_10733 ^@ http://purl.uniprot.org/uniprot/I1S1V9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/229533:FGSG_09731 ^@ http://purl.uniprot.org/uniprot/I1RZA1 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07329 ^@ http://purl.uniprot.org/uniprot/I1RT36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/229533:FGSG_10725 ^@ http://purl.uniprot.org/uniprot/I1S1V3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/229533:FGSG_01884 ^@ http://purl.uniprot.org/uniprot/I1RE12 ^@ Similarity ^@ Belongs to the polyketide transferase af380 family. http://togogenome.org/gene/229533:FGSG_05153 ^@ http://purl.uniprot.org/uniprot/I1RMG3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_06053 ^@ http://purl.uniprot.org/uniprot/I1RPS4 ^@ Similarity ^@ Belongs to the prenylcysteine oxidase family. http://togogenome.org/gene/229533:FGSG_09884 ^@ http://purl.uniprot.org/uniprot/I1RZN4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04402 ^@ http://purl.uniprot.org/uniprot/I1RKJ5 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. UreG subfamily. http://togogenome.org/gene/229533:FGSG_09909 ^@ http://purl.uniprot.org/uniprot/I1RZQ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02690 ^@ http://purl.uniprot.org/uniprot/I1RG41 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_10129 ^@ http://purl.uniprot.org/uniprot/A0A1I9F4M0|||http://purl.uniprot.org/uniprot/I1S0A8 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EFG1/PHD1/stuA family.|||Does not develop perithecia and sexual ascospores, and lacks conidiophores and phialides (PubMed:20879840). Greatly reduces pathogenicity on wheat heads and production of secondary metabolites such as deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Leads to up-regulation of cell-cycle genes which promoters are highly enriched in StuA-response elements (StRE) (PubMed:20879840).|||Nucleus|||Transcription factor that regulates asexual reproduction (PubMed:20879840). Binds the StuA-response elements (StRE) with the consensus sequence 5'-(A/T)CGCG(T/A)N(A/C)-3' at the promoters of target genes (PubMed:20879840). Controls the expression of the gene clusters involved in the production of deoxynivalenol (DON) and 15-acetyldeoxynivalenol (15ADON) (PubMed:20879840). Regulates the expression of genes involved in chitin and glucan metabolism (PubMed:20879840). Controls also catalase activity and cell surface hydrophobicity (PubMed:20879840). Plays an important role in pathogenicity (PubMed:20879840). http://togogenome.org/gene/229533:FGSG_12373 ^@ http://purl.uniprot.org/uniprot/I1S6A2 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_06359 ^@ http://purl.uniprot.org/uniprot/I1RQL4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08844 ^@ http://purl.uniprot.org/uniprot/I1RX03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_10384 ^@ http://purl.uniprot.org/uniprot/I1S0Z2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10268 ^@ http://purl.uniprot.org/uniprot/I1S0N4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_00044 ^@ http://purl.uniprot.org/uniprot/I1R9B1 ^@ Function|||Similarity ^@ AB hydrolase superfamily protein; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).|||Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/229533:FGSG_00080 ^@ http://purl.uniprot.org/uniprot/V6QSM8 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/229533:FGSG_06002 ^@ http://purl.uniprot.org/uniprot/I1RPM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.|||Nucleus http://togogenome.org/gene/229533:FGSG_01016 ^@ http://purl.uniprot.org/uniprot/I1RBS6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/229533:FGSG_07284 ^@ http://purl.uniprot.org/uniprot/I1RSZ6 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/229533:FGSG_09005 ^@ http://purl.uniprot.org/uniprot/I1RXD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA12 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08819 ^@ http://purl.uniprot.org/uniprot/A0A1I9F9P5|||http://purl.uniprot.org/uniprot/Q4I1T9 ^@ Similarity ^@ Belongs to the EFR3 family. http://togogenome.org/gene/229533:FGSG_10223 ^@ http://purl.uniprot.org/uniprot/A0A1I9F3V3|||http://purl.uniprot.org/uniprot/Q4HXT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.|||Belongs to the PIGF family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_09331 ^@ http://purl.uniprot.org/uniprot/I1RY91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08495 ^@ http://purl.uniprot.org/uniprot/I1RW41 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/229533:FGSG_04558 ^@ http://purl.uniprot.org/uniprot/I1RKY6 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/229533:FGSG_08309 ^@ http://purl.uniprot.org/uniprot/I1RVM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_07942 ^@ http://purl.uniprot.org/uniprot/I1RUP2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDS23 family.|||Cytoplasm|||Involved in DNA replication and cell separation. http://togogenome.org/gene/229533:FGSG_05409 ^@ http://purl.uniprot.org/uniprot/I1RN46 ^@ Cofactor|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit. http://togogenome.org/gene/229533:FGSG_09327 ^@ http://purl.uniprot.org/uniprot/I1RY87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06308 ^@ http://purl.uniprot.org/uniprot/I1RQG6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/229533:FGSG_09894 ^@ http://purl.uniprot.org/uniprot/I1RZP4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/229533:FGSG_11274 ^@ http://purl.uniprot.org/uniprot/I1S399 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_08852 ^@ http://purl.uniprot.org/uniprot/Q4I1Q6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/229533:FGSG_04582 ^@ http://purl.uniprot.org/uniprot/V6R1K4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. http://togogenome.org/gene/229533:FGSG_02112 ^@ http://purl.uniprot.org/uniprot/I1REM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08980 ^@ http://purl.uniprot.org/uniprot/V6RM09 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_10760 ^@ http://purl.uniprot.org/uniprot/I1S1Y2 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/229533:FGSG_12275 ^@ http://purl.uniprot.org/uniprot/I1S604 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01014 ^@ http://purl.uniprot.org/uniprot/I1RBS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/229533:FGSG_12202 ^@ http://purl.uniprot.org/uniprot/I1S5T1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for the ferulic acid decarboxylase FDC1. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Mitochondrion|||Oligomer. http://togogenome.org/gene/229533:FGSG_09547 ^@ http://purl.uniprot.org/uniprot/I1RYT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_11347 ^@ http://purl.uniprot.org/uniprot/I1S3G5 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_06996 ^@ http://purl.uniprot.org/uniprot/I1RS83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.|||Nucleus http://togogenome.org/gene/229533:FGSG_01128 ^@ http://purl.uniprot.org/uniprot/I1RC27 ^@ Function|||Subcellular Location Annotation ^@ RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_01352 ^@ http://purl.uniprot.org/uniprot/I1RCN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04703 ^@ http://purl.uniprot.org/uniprot/I1RLB6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/229533:FGSG_05608 ^@ http://purl.uniprot.org/uniprot/I1RNM5 ^@ Similarity ^@ Belongs to the palC family. http://togogenome.org/gene/229533:FGSG_08909 ^@ http://purl.uniprot.org/uniprot/I1RX59 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/229533:FGSG_09280 ^@ http://purl.uniprot.org/uniprot/V6RV57 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/229533:FGSG_05036 ^@ http://purl.uniprot.org/uniprot/I1RM55 ^@ Similarity ^@ Belongs to the glutaminase PdxT/SNO family. http://togogenome.org/gene/229533:FGSG_01551 ^@ http://purl.uniprot.org/uniprot/I1RD62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/229533:FGSG_09795 ^@ http://purl.uniprot.org/uniprot/I1RZF6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_06549 ^@ http://purl.uniprot.org/uniprot/I1RR40 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_00667 ^@ http://purl.uniprot.org/uniprot/I1RAX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01323 ^@ http://purl.uniprot.org/uniprot/I1RCK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_10423 ^@ http://purl.uniprot.org/uniprot/I1S129 ^@ Similarity ^@ Belongs to the RUS1 family. http://togogenome.org/gene/229533:FGSG_01035 ^@ http://purl.uniprot.org/uniprot/I1RBU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/229533:FGSG_01936 ^@ http://purl.uniprot.org/uniprot/I1RE61 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06791 ^@ http://purl.uniprot.org/uniprot/I1RRQ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LOC1 family.|||Component of the 66S pre-ribosomal particle.|||Required for efficient assembly and nuclear export of the 60S ribosomal subunit. http://togogenome.org/gene/229533:FGSG_09690 ^@ http://purl.uniprot.org/uniprot/Q4HZB8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. FKBP1 subfamily.|||Cytoplasm|||Inhibited by both FK506 and rapamycin.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/229533:FGSG_08116 ^@ http://purl.uniprot.org/uniprot/I1RV54 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_11440 ^@ http://purl.uniprot.org/uniprot/I1S3P9 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/229533:FGSG_08814 ^@ http://purl.uniprot.org/uniprot/I1RWX8 ^@ Similarity ^@ Belongs to the SF3B5 family. http://togogenome.org/gene/229533:FGSG_00730 ^@ http://purl.uniprot.org/uniprot/A0A1I9EWE1|||http://purl.uniprot.org/uniprot/Q4IPX8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00986 ^@ http://purl.uniprot.org/uniprot/I1RBQ2 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/229533:FGSG_11304 ^@ http://purl.uniprot.org/uniprot/A0A1I9FPA3|||http://purl.uniprot.org/uniprot/I1S3C6 ^@ Activity Regulation|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family.|||Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops.|||Expression is under the control of transcription factor XYR1 and highly induced by xylan, carboxymethylcellulose (CMC), and hop cell wall.|||Inhibited by the wheat xylanase inhibiting protein I (XIP-I).|||Secreted http://togogenome.org/gene/229533:FGSG_06923 ^@ http://purl.uniprot.org/uniprot/Q4I785 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).|||Belongs to the glycosyltransferase 22 family. PIGZ subfamily.|||Endoplasmic reticulum membrane http://togogenome.org/gene/229533:FGSG_02787 ^@ http://purl.uniprot.org/uniprot/I1RGC8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04131 ^@ http://purl.uniprot.org/uniprot/I1RJU9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_07103 ^@ http://purl.uniprot.org/uniprot/I1RSI2 ^@ Function|||Similarity ^@ Belongs to the inositol monophosphatase superfamily.|||Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. http://togogenome.org/gene/229533:FGSG_00916 ^@ http://purl.uniprot.org/uniprot/I1RBJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/229533:FGSG_06690 ^@ http://purl.uniprot.org/uniprot/I1RRG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/229533:FGSG_04451 ^@ http://purl.uniprot.org/uniprot/A0A1I9FG04|||http://purl.uniprot.org/uniprot/Q4IEA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum membrane|||Interacts with missfolded ER lumenal proteins.|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity). http://togogenome.org/gene/229533:FGSG_00370 ^@ http://purl.uniprot.org/uniprot/I1RA46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10522 ^@ http://purl.uniprot.org/uniprot/I1S1C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/229533:FGSG_02761 ^@ http://purl.uniprot.org/uniprot/I1RGA3 ^@ Similarity ^@ Belongs to the Tim44 family. http://togogenome.org/gene/229533:FGSG_11567 ^@ http://purl.uniprot.org/uniprot/I1S414 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07233 ^@ http://purl.uniprot.org/uniprot/I1RSU8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/229533:FGSG_02666 ^@ http://purl.uniprot.org/uniprot/I1RG17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cutinase family.|||Catalyzes the hydrolysis of complex carboxylic polyesters found in the cell wall of plants. Degrades cutin, a macromolecule that forms the structure of the plant cuticle.|||Secreted http://togogenome.org/gene/229533:FGSG_06108 ^@ http://purl.uniprot.org/uniprot/I1RPX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00564 ^@ http://purl.uniprot.org/uniprot/I1RAN2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/229533:FGSG_09853 ^@ http://purl.uniprot.org/uniprot/I1RZK6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/229533:FGSG_01189 ^@ http://purl.uniprot.org/uniprot/I1RC86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TIM54 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_08576 ^@ http://purl.uniprot.org/uniprot/I1RWB3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00740 ^@ http://purl.uniprot.org/uniprot/I1RB35 ^@ Cofactor|||PTM|||Similarity ^@ Binds 2 nickel ions per subunit.|||Carbamylation allows a single lysine to coordinate two nickel ions.|||In the C-terminal section; belongs to the metallo-dependent hydrolases superfamily. Urease alpha subunit family. http://togogenome.org/gene/229533:FGSG_05026 ^@ http://purl.uniprot.org/uniprot/I1RM47 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/229533:FGSG_13120 ^@ http://purl.uniprot.org/uniprot/I1S8E2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/229533:FGSG_05659 ^@ http://purl.uniprot.org/uniprot/I1RNS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07411 ^@ http://purl.uniprot.org/uniprot/I1RTB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tellurite-resistance/dicarboxylate transporter (TDT) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00186 ^@ http://purl.uniprot.org/uniprot/I1R9N5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/229533:FGSG_03951 ^@ http://purl.uniprot.org/uniprot/I1RJD6 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFA/CMAS family.|||Catalyzes methylation of the sphingoid base component of glucosylceramides (GluCers) at the C9-position. Sphingolipid C9-methylation requires 4,8-desaturated ceramides as substrates. Glucosylceramides play important roles in the growth, differentiation and pathogenicity. The methyl group at the C9-position distinguishes fungal glucosylceramides from those of plants and animals, and may thus play a role in host-pathogen interactions enabling the host to recognize the fungal attack and initiate specific defense responses. However, C-9 methylation of GlcCers is not essential for the sensitivity of F.graminearum to plant defensins MsDef1 and RsAFP2.|||In contrast to the knockout of its paralog MT2, has no effect on methylation of GluCers and exhibits no growth defects. However, a double-knockout with its paralog MT2 is not viable.|||Membrane http://togogenome.org/gene/229533:FGSG_12442 ^@ http://purl.uniprot.org/uniprot/I1S6H1 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/229533:FGSG_00443 ^@ http://purl.uniprot.org/uniprot/I1RAB6 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/229533:FGSG_00626 ^@ http://purl.uniprot.org/uniprot/I1RAU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_05275 ^@ http://purl.uniprot.org/uniprot/I1RMS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/229533:FGSG_07021 ^@ http://purl.uniprot.org/uniprot/I1RSA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/229533:FGSG_13196 ^@ http://purl.uniprot.org/uniprot/I1S8L8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_09532 ^@ http://purl.uniprot.org/uniprot/I1RYS3 ^@ Function|||Similarity ^@ Belongs to the inositol monophosphatase superfamily.|||Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. http://togogenome.org/gene/229533:FGSG_06167 ^@ http://purl.uniprot.org/uniprot/I1RQ33 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL29 family.|||Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S).|||Mitochondrion http://togogenome.org/gene/229533:FGSG_08777 ^@ http://purl.uniprot.org/uniprot/Q4I1Y1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family. PPIL1 subfamily.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/229533:FGSG_11087 ^@ http://purl.uniprot.org/uniprot/I1S2T4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12028 ^@ http://purl.uniprot.org/uniprot/I1S5B0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/229533:FGSG_02454 ^@ http://purl.uniprot.org/uniprot/I1RFH9 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/229533:FGSG_05062 ^@ http://purl.uniprot.org/uniprot/I1RM79 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/229533:FGSG_05152 ^@ http://purl.uniprot.org/uniprot/I1RMG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynactin 150 kDa subunit family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_12154 ^@ http://purl.uniprot.org/uniprot/I1S5N3 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_03996 ^@ http://purl.uniprot.org/uniprot/I1RJH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_01225 ^@ http://purl.uniprot.org/uniprot/V6QX21 ^@ Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236).|||Vacuolar effluxer which mediate the efflux of leucine and other amino acids resulting from autophagic degradation (By similarity). The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_08658 ^@ http://purl.uniprot.org/uniprot/I1RWI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/229533:FGSG_11263 ^@ http://purl.uniprot.org/uniprot/V6RW01 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_07695 ^@ http://purl.uniprot.org/uniprot/I1RU20 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_01584 ^@ http://purl.uniprot.org/uniprot/I1RD92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05805 ^@ http://purl.uniprot.org/uniprot/I1RP53 ^@ Function|||Induction|||Similarity|||Subunit ^@ Belongs to the carbon-nitrogen hydrolase superfamily. Nitrilase family.|||By cyanide.|||Catalyzes the hydration of cyanide to formamide. Degradation of cyanide may be important for plant pathogenic fungi in infection of cyanogenic plants.|||Oligomer of dimers, forming left-handed helical fibers. http://togogenome.org/gene/229533:FGSG_02829 ^@ http://purl.uniprot.org/uniprot/I1RGG8 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_10319 ^@ http://purl.uniprot.org/uniprot/V6RSM7 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/229533:FGSG_02771 ^@ http://purl.uniprot.org/uniprot/I1RGB3 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_09178 ^@ http://purl.uniprot.org/uniprot/I1RXV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_04055 ^@ http://purl.uniprot.org/uniprot/I1RJN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06111 ^@ http://purl.uniprot.org/uniprot/I1RPX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/229533:FGSG_02171 ^@ http://purl.uniprot.org/uniprot/I1RES1 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_07669 ^@ http://purl.uniprot.org/uniprot/I1RTZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08621 ^@ http://purl.uniprot.org/uniprot/Q4I2D7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/229533:FGSG_05610 ^@ http://purl.uniprot.org/uniprot/I1RNM7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_06389 ^@ http://purl.uniprot.org/uniprot/I1RQP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DASH complex DAD4 family.|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/229533:FGSG_08567 ^@ http://purl.uniprot.org/uniprot/I1RWA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03695 ^@ http://purl.uniprot.org/uniprot/I1RIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_07480 ^@ http://purl.uniprot.org/uniprot/I1RTH6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_08481 ^@ http://purl.uniprot.org/uniprot/I1RW28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Chromosome http://togogenome.org/gene/229533:FGSG_10067 ^@ http://purl.uniprot.org/uniprot/I1S051 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/229533:FGSG_10859 ^@ http://purl.uniprot.org/uniprot/I1S273 ^@ Function ^@ Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates. http://togogenome.org/gene/229533:FGSG_10077 ^@ http://purl.uniprot.org/uniprot/I1S061 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/229533:FGSG_03537 ^@ http://purl.uniprot.org/uniprot/A0A1I9FCV5|||http://purl.uniprot.org/uniprot/Q00909 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the trichodiene synthase family.|||TS is a member of the terpene cyclase group of enzymes. It catalyzes the isomerization and cyclization of farnesyl pyro-phosphate to form trichodiene, the first cyclic intermediate in the biosynthetic pathway for trichothecenes. It serves to branch trichothecene biosynthesis from the isoprenoid pathway.|||Trichothecenes are sesquiterpenoid toxins that act by inhibiting protein biosynthesis. http://togogenome.org/gene/229533:FGSG_03629 ^@ http://purl.uniprot.org/uniprot/I1RIJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-glucuronidase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Releases 4-O-methylglucuronic acid from xylan.|||Belongs to the glycosyl hydrolase 67 family.|||Secreted http://togogenome.org/gene/229533:FGSG_00767 ^@ http://purl.uniprot.org/uniprot/I1RB60 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_10919 ^@ http://purl.uniprot.org/uniprot/I1S2D0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_04479 ^@ http://purl.uniprot.org/uniprot/A0A1I9FGN6|||http://purl.uniprot.org/uniprot/Q4IE79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_10762 ^@ http://purl.uniprot.org/uniprot/I1S1Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-Q/OKP1 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_10651 ^@ http://purl.uniprot.org/uniprot/I1S1P0 ^@ Similarity ^@ Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_03603 ^@ http://purl.uniprot.org/uniprot/I1RIH0 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/229533:FGSG_03017 ^@ http://purl.uniprot.org/uniprot/I1RGY5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/229533:FGSG_07397 ^@ http://purl.uniprot.org/uniprot/I1RT96 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/229533:FGSG_04685 ^@ http://purl.uniprot.org/uniprot/I1RL99 ^@ Similarity ^@ Belongs to the intradiol ring-cleavage dioxygenase family. http://togogenome.org/gene/229533:FGSG_06340 ^@ http://purl.uniprot.org/uniprot/I1RQJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/229533:FGSG_04944 ^@ http://purl.uniprot.org/uniprot/I1RLX4 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/229533:FGSG_00807 ^@ http://purl.uniprot.org/uniprot/I1RB97 ^@ Subcellular Location Annotation|||Subunit ^@ Homodimer.|||Secreted http://togogenome.org/gene/229533:FGSG_08158 ^@ http://purl.uniprot.org/uniprot/I1RV93 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/229533:FGSG_08277 ^@ http://purl.uniprot.org/uniprot/I1RVJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPM3 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum membrane|||Membrane|||Stabilizer subunit of the dolichol-phosphate mannose (DPM) synthase complex; tethers catalytic subunit to the ER. http://togogenome.org/gene/229533:FGSG_04773 ^@ http://purl.uniprot.org/uniprot/I1RLH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_10939 ^@ http://purl.uniprot.org/uniprot/I1S2E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 18 family. Chitinase class V subfamily.|||Secreted http://togogenome.org/gene/229533:FGSG_06804 ^@ http://purl.uniprot.org/uniprot/A0A1I9FK29|||http://purl.uniprot.org/uniprot/Q4I7K4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.|||Cytoplasm|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_08336 ^@ http://purl.uniprot.org/uniprot/I1RVQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05542 ^@ http://purl.uniprot.org/uniprot/I1RNG5 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/229533:FGSG_07207 ^@ http://purl.uniprot.org/uniprot/I1RSS5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_07458 ^@ http://purl.uniprot.org/uniprot/I1RTF5 ^@ Function|||Similarity ^@ Belongs to the MBF1 family.|||Belongs to the cyanase family.|||Catalyzes the reaction of cyanate with bicarbonate to produce ammonia and carbon dioxide. http://togogenome.org/gene/229533:FGSG_01606 ^@ http://purl.uniprot.org/uniprot/I1RDB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/229533:FGSG_07198 ^@ http://purl.uniprot.org/uniprot/I1RSR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08055 ^@ http://purl.uniprot.org/uniprot/I1RUZ5 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_05547 ^@ http://purl.uniprot.org/uniprot/I1RNG8 ^@ Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.|||Blocks autophagy (PubMed:28894236). Significantly decreases the radial growth of colonies under nutrient-rich conditions (PubMed:28894236). Strongly reduces conidiation and completely fails to form any perithecia (PubMed:28894236). Causes only mild infection in point-inoculated spikelets of flowering wheat heads and impairs the spreading to nearby spikelets (PubMed:28894236).|||Cytoplasm|||Homodimer (By similarity). Dimerization requires the presence of ATG13 (By similarity). Forms a ternary complex with ATG13 and ATG17 (By similarity).|||Preautophagosomal structure membrane|||Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes (By similarity). Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome (By similarity). Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production (By similarity). Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates (By similarity). Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8 (By similarity). Autophagy is required for proper vegetative growth, asexual/sexual reproduction, and full virulence (PubMed:28894236). Autophagy is particularly involved in the biosynthesis of deoxynivalenol (DON), an important virulence determinant (PubMed:28894236).|||The C-terminal region of ATG1 responsible for ATG13-binding comprises six alpha-helices which fold into two antiparallel three-helix bundles resembling each other (By similarity).|||The LIR motif is required for the interaction with ATG8 and for the association of ATG1 with autophagosomes (By similarity). http://togogenome.org/gene/229533:FGSG_00578 ^@ http://purl.uniprot.org/uniprot/I1RAP5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_02142 ^@ http://purl.uniprot.org/uniprot/I1REP8 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/229533:FGSG_10666 ^@ http://purl.uniprot.org/uniprot/I1S1Q3 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sterol desaturase family.|||C-4 methylsterol oxidase; part of the third module of ergosterol biosynthesis pathway that includes the late steps of the pathway (By similarity). ERG25 is a catalytic component of the C-4 demethylation complex that catalyzes the conversion of 4,4-dimethylfecosterol into fecosterol via 4-methylfecosterol (By similarity). The third module or late pathway involves the ergosterol synthesis itself through consecutive reactions that mainly occur in the endoplasmic reticulum (ER) membrane. Firstly, the squalene synthase ERG9 catalyzes the condensation of 2 farnesyl pyrophosphate moieties to form squalene, which is the precursor of all steroids. Squalene synthase is crucial for balancing the incorporation of farnesyl diphosphate (FPP) into sterol and nonsterol isoprene synthesis. Secondly, squalene is converted into lanosterol by the consecutive action of the squalene epoxidase ERG1 and the lanosterol synthase ERG7. Then, the delta(24)-sterol C-methyltransferase ERG6 methylates lanosterol at C-24 to produce eburicol. Eburicol is the substrate of the sterol 14-alpha demethylase encoded by CYP51A, CYP51B and CYP51C, to yield 4,4,24-trimethyl ergosta-8,14,24(28)-trienol. CYP51B encodes the enzyme primarily responsible for sterol 14-alpha-demethylation, and plays an essential role in ascospore formation. CYP51A encodes an additional sterol 14-alpha-demethylase, induced on ergosterol depletion and responsible for the intrinsic variation in azole sensitivity. The third CYP51 isoform, CYP51C, does not encode a sterol 14-alpha-demethylase, but is required for full virulence on host wheat ears. The C-14 reductase ERG24 then reduces the C14=C15 double bond which leads to 4,4-dimethylfecosterol. A sequence of further demethylations at C-4, involving the C-4 demethylation complex containing the C-4 methylsterol oxidases ERG25, the sterol-4-alpha-carboxylate 3-dehydrogenase ERG26 and the 3-keto-steroid reductase ERG27, leads to the production of fecosterol via 4-methylfecosterol. ERG28 has a role as a scaffold to help anchor ERG25, ERG26 and ERG27 to the endoplasmic reticulum. The C-8 sterol isomerase ERG2 then catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols and thus converts fecosterol to episterol. The sterol-C5-desaturases ERG3A and ERG3BB then catalyze the introduction of a C-5 double bond in the B ring to produce 5-dehydroepisterol. The C-22 sterol desaturases ERG5A and ERG5B further convert 5-dehydroepisterol into ergosta-5,7,22,24(28)-tetraen-3beta-ol by forming the C-22(23) double bond in the sterol side chain. Finally, ergosta-5,7,22,24(28)-tetraen-3beta-ol is substrate of the C-24(28) sterol reductase ERG4 to produce ergosterol (Probable).|||Endoplasmic reticulum membrane|||Heterotetramer of ERG25, ERG26, ERG27 and ERG28 (By similarity). ERG28 acts as a scaffold to tether ERG27 and other 4,4-demethylation-related enzymes, forming a demethylation enzyme complex, in the endoplasmic reticulum (By similarity).|||In Fusarium, the biosynthesis pathway of the sterol precursors leading to the prevalent sterol ergosterol differs from yeast. The ringsystem of lanosterol in S.cerevisiae is firstly demethylised in three enzymatic steps leading to the intermediate zymosterol and secondly a methyl group is added to zymosterol by the sterol 24-C-methyltransferase to form fecosterol. In Fusarium, lanosterol is firstly transmethylated by the sterol 24-C-methyltransferase leading to the intermediate eburicol and secondly demethylated in three steps to form fecosterol.|||The histidine box domains may contain the active site and/or be involved in metal ion binding. http://togogenome.org/gene/229533:FGSG_06875 ^@ http://purl.uniprot.org/uniprot/I1RRX5 ^@ Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/229533:FGSG_06737 ^@ http://purl.uniprot.org/uniprot/A0A1I9FL67|||http://purl.uniprot.org/uniprot/Q4I7S1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YAF9 family.|||Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).|||Cytoplasm|||Nucleus|||The coiled-coil domain is required for assembly into the NuA4 complex. http://togogenome.org/gene/229533:FGSG_01762 ^@ http://purl.uniprot.org/uniprot/I1RDP8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03014 ^@ http://purl.uniprot.org/uniprot/I1RGY2 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/229533:FGSG_09262 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJC0|||http://purl.uniprot.org/uniprot/Q4I0J6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/229533:FGSG_00761 ^@ http://purl.uniprot.org/uniprot/I1RB54 ^@ Similarity ^@ Belongs to the CDIP1/LITAF family. http://togogenome.org/gene/229533:FGSG_03985 ^@ http://purl.uniprot.org/uniprot/I1RJG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10181 ^@ http://purl.uniprot.org/uniprot/I1S0F6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/229533:FGSG_06473 ^@ http://purl.uniprot.org/uniprot/I1RQX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_13111 ^@ http://purl.uniprot.org/uniprot/I1S8D3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/229533:FGSG_09289 ^@ http://purl.uniprot.org/uniprot/I1RY54 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/229533:FGSG_13546 ^@ http://purl.uniprot.org/uniprot/I1S9L5 ^@ Similarity ^@ Belongs to the peptidase M4 family. http://togogenome.org/gene/229533:FGSG_04351 ^@ http://purl.uniprot.org/uniprot/I1RKE9 ^@ Similarity ^@ Belongs to the WD repeat WDR48 family. http://togogenome.org/gene/229533:FGSG_10261 ^@ http://purl.uniprot.org/uniprot/I1S0M8 ^@ Similarity ^@ Belongs to the ADIP family. http://togogenome.org/gene/229533:FGSG_07407 ^@ http://purl.uniprot.org/uniprot/I1RTA6 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/229533:FGSG_11494 ^@ http://purl.uniprot.org/uniprot/I1S3U6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 43 family. http://togogenome.org/gene/229533:FGSG_09395 ^@ http://purl.uniprot.org/uniprot/I1RYE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SWC3 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_00818 ^@ http://purl.uniprot.org/uniprot/I1RBA6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/229533:FGSG_09952 ^@ http://purl.uniprot.org/uniprot/I1RZU7 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07771 ^@ http://purl.uniprot.org/uniprot/I1RU87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08425 ^@ http://purl.uniprot.org/uniprot/I1RVX8 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/229533:FGSG_06093 ^@ http://purl.uniprot.org/uniprot/I1RPW1 ^@ Similarity ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family. http://togogenome.org/gene/229533:FGSG_02641 ^@ http://purl.uniprot.org/uniprot/V6R0R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_10219 ^@ http://purl.uniprot.org/uniprot/I1S0J1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/229533:FGSG_07331 ^@ http://purl.uniprot.org/uniprot/I1RT38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/229533:FGSG_12349 ^@ http://purl.uniprot.org/uniprot/I1S678 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anthrone oxygenase family.|||Membrane http://togogenome.org/gene/229533:FGSG_01541 ^@ http://purl.uniprot.org/uniprot/I1RD52 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/229533:FGSG_03447 ^@ http://purl.uniprot.org/uniprot/I1RI26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09155 ^@ http://purl.uniprot.org/uniprot/I1RXT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_03860 ^@ http://purl.uniprot.org/uniprot/I1RJ57 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_13536 ^@ http://purl.uniprot.org/uniprot/I1S9K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/229533:FGSG_01121 ^@ http://purl.uniprot.org/uniprot/I1RC20 ^@ Domain|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DENR family.|||Cytoplasm|||Interacts with the 40S ribosomal subunit.|||The SUI1 domain may be involved in RNA binding. http://togogenome.org/gene/229533:FGSG_10362 ^@ http://purl.uniprot.org/uniprot/I1S0X1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_08485 ^@ http://purl.uniprot.org/uniprot/I1RW32 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/229533:FGSG_08442 ^@ http://purl.uniprot.org/uniprot/I1RVZ2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/229533:FGSG_07113 ^@ http://purl.uniprot.org/uniprot/I1RSJ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/229533:FGSG_06453 ^@ http://purl.uniprot.org/uniprot/I1RQV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02931 ^@ http://purl.uniprot.org/uniprot/I1RGQ8 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_05865 ^@ http://purl.uniprot.org/uniprot/I1RPA7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/229533:FGSG_08034 ^@ http://purl.uniprot.org/uniprot/I1RUX5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_01931 ^@ http://purl.uniprot.org/uniprot/I1RE57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_06388 ^@ http://purl.uniprot.org/uniprot/I1RQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07258 ^@ http://purl.uniprot.org/uniprot/I1RSX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/229533:FGSG_12292 ^@ http://purl.uniprot.org/uniprot/I1S621 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/229533:FGSG_05431 ^@ http://purl.uniprot.org/uniprot/V6RBN2 ^@ Similarity|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/229533:FGSG_01008 ^@ http://purl.uniprot.org/uniprot/I1RBS0 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/229533:FGSG_00047 ^@ http://purl.uniprot.org/uniprot/I1R9B4 ^@ Function|||Similarity ^@ Belongs to the AMT4 thioesterase family.|||Probable thioesterase; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable). http://togogenome.org/gene/229533:FGSG_00843 ^@ http://purl.uniprot.org/uniprot/I1RBC7 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/229533:FGSG_10318 ^@ http://purl.uniprot.org/uniprot/I1S0T1 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/229533:FGSG_02147 ^@ http://purl.uniprot.org/uniprot/I1REQ2 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_03140 ^@ http://purl.uniprot.org/uniprot/I1RH95 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_03272 ^@ http://purl.uniprot.org/uniprot/I1RHL3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_00773 ^@ http://purl.uniprot.org/uniprot/I1RB66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_08830 ^@ http://purl.uniprot.org/uniprot/I1RWZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Membrane http://togogenome.org/gene/229533:FGSG_10537 ^@ http://purl.uniprot.org/uniprot/I1S1D7 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/229533:FGSG_01919 ^@ http://purl.uniprot.org/uniprot/A0A1I9F0D0|||http://purl.uniprot.org/uniprot/Q4ILI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO70 family.|||Bud|||Bud neck|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity).|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst. http://togogenome.org/gene/229533:FGSG_08385 ^@ http://purl.uniprot.org/uniprot/V6RLW2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/229533:FGSG_01596 ^@ http://purl.uniprot.org/uniprot/I1RDA4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_05344 ^@ http://purl.uniprot.org/uniprot/A0A1I9FYE8|||http://purl.uniprot.org/uniprot/Q4IBR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/229533:FGSG_06325 ^@ http://purl.uniprot.org/uniprot/I1RQI1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/229533:FGSG_06655 ^@ http://purl.uniprot.org/uniprot/I1RRD6 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/229533:FGSG_07038 ^@ http://purl.uniprot.org/uniprot/V6RGY3 ^@ Function|||Subcellular Location Annotation ^@ RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit.|||nucleolus http://togogenome.org/gene/229533:FGSG_05390 ^@ http://purl.uniprot.org/uniprot/A0A1I9FVT7|||http://purl.uniprot.org/uniprot/Q4IBL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_00200 ^@ http://purl.uniprot.org/uniprot/I1R9P7 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_02151 ^@ http://purl.uniprot.org/uniprot/I1REQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07402 ^@ http://purl.uniprot.org/uniprot/I1RTA1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/229533:FGSG_09333 ^@ http://purl.uniprot.org/uniprot/A0A1I9FGR7|||http://purl.uniprot.org/uniprot/Q4I0C5 ^@ Function|||Subcellular Location Annotation ^@ May act as a transcriptional repressor of multidrug resistance genes.|||Nucleus http://togogenome.org/gene/229533:FGSG_02136 ^@ http://purl.uniprot.org/uniprot/I1REP2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07199 ^@ http://purl.uniprot.org/uniprot/I1RSR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/229533:FGSG_11322 ^@ http://purl.uniprot.org/uniprot/I1S3E4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09673 ^@ http://purl.uniprot.org/uniprot/I1RZ48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08799 ^@ http://purl.uniprot.org/uniprot/I1RWW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_03898 ^@ http://purl.uniprot.org/uniprot/I1RJ90 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_00732 ^@ http://purl.uniprot.org/uniprot/I1RB27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with TAN1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/229533:FGSG_05002 ^@ http://purl.uniprot.org/uniprot/I1RM25 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06642 ^@ http://purl.uniprot.org/uniprot/I1RRC4 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/229533:FGSG_03922 ^@ http://purl.uniprot.org/uniprot/V6R5Q6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_08749 ^@ http://purl.uniprot.org/uniprot/I1RWR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10076 ^@ http://purl.uniprot.org/uniprot/I1S060 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP25 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.|||DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.|||nucleolus http://togogenome.org/gene/229533:FGSG_11249 ^@ http://purl.uniprot.org/uniprot/I1S379 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/229533:FGSG_11389 ^@ http://purl.uniprot.org/uniprot/I1S3K2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_04910 ^@ http://purl.uniprot.org/uniprot/I1RLU1 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/229533:FGSG_04856 ^@ http://purl.uniprot.org/uniprot/I1RLP3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 10 (cellulase F) family. http://togogenome.org/gene/229533:FGSG_02145 ^@ http://purl.uniprot.org/uniprot/I1REQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07551 ^@ http://purl.uniprot.org/uniprot/I1RTN8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/229533:FGSG_08169 ^@ http://purl.uniprot.org/uniprot/I1RVA3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_11627 ^@ http://purl.uniprot.org/uniprot/A0A1I9FJX4|||http://purl.uniprot.org/uniprot/Q4HTT1 ^@ Caution|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by ESA1 to form H2AK4ac and H2AK7ac.|||Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-6; H2AK7ac = acetylated Lys-10. http://togogenome.org/gene/229533:FGSG_04973 ^@ http://purl.uniprot.org/uniprot/I1RM01 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/229533:FGSG_02347 ^@ http://purl.uniprot.org/uniprot/I1RF80 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/229533:FGSG_01314 ^@ http://purl.uniprot.org/uniprot/I1RCJ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/229533:FGSG_05293 ^@ http://purl.uniprot.org/uniprot/I1RMU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09039 ^@ http://purl.uniprot.org/uniprot/I1RXH0 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_04943 ^@ http://purl.uniprot.org/uniprot/I1RLX3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12814 ^@ http://purl.uniprot.org/uniprot/I1S7J1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/229533:FGSG_02662 ^@ http://purl.uniprot.org/uniprot/I1RG13 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03941 ^@ http://purl.uniprot.org/uniprot/V6R5P0 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/229533:FGSG_09780 ^@ http://purl.uniprot.org/uniprot/I1RZE1 ^@ Function ^@ tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease. http://togogenome.org/gene/229533:FGSG_00623 ^@ http://purl.uniprot.org/uniprot/I1RAT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_02743 ^@ http://purl.uniprot.org/uniprot/I1RG87 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00220 ^@ http://purl.uniprot.org/uniprot/I1R9R5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05635 ^@ http://purl.uniprot.org/uniprot/I1RNQ1 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/229533:FGSG_08554 ^@ http://purl.uniprot.org/uniprot/I1RW93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBT5 family.|||Membrane|||cell wall http://togogenome.org/gene/229533:FGSG_09220 ^@ http://purl.uniprot.org/uniprot/I1RXZ3 ^@ Similarity ^@ Belongs to the MGR2 family. http://togogenome.org/gene/229533:FGSG_03311 ^@ http://purl.uniprot.org/uniprot/I1RHQ0 ^@ Similarity|||Subunit ^@ Belongs to the mannitol dehydrogenase family.|||Monomer. http://togogenome.org/gene/229533:FGSG_06935 ^@ http://purl.uniprot.org/uniprot/I1RS28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01505 ^@ http://purl.uniprot.org/uniprot/I1RD18 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/229533:FGSG_00660 ^@ http://purl.uniprot.org/uniprot/I1RAW7 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/229533:FGSG_09497 ^@ http://purl.uniprot.org/uniprot/I1RYN9 ^@ Similarity ^@ Belongs to the SH3YL1 family. http://togogenome.org/gene/229533:FGSG_01306 ^@ http://purl.uniprot.org/uniprot/I1RCI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Golgi apparatus membrane|||Membrane|||Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. http://togogenome.org/gene/229533:FGSG_03780 ^@ http://purl.uniprot.org/uniprot/I1RIY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01666 ^@ http://purl.uniprot.org/uniprot/I1RDH0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08439 ^@ http://purl.uniprot.org/uniprot/I1RVZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/229533:FGSG_10461 ^@ http://purl.uniprot.org/uniprot/I1S163 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Abolishes the production of fusarielins F, G and H, but accumulates the intermediate prefusarielin.|||Belongs to the cytochrome P450 family.|||Cytochrome P450 monooxygenase; part of the gene cluster that mediates the biosynthesis of fusarielins F, G and H, decaketide compounds with 5 methylations and a decaline core that act as mycoestrogens as they stimulate growth of MCF-7 breast cancer cells (PubMed:22252016, PubMed:27983606). The initial compound in the pathway is produced by the reducing polyketide synthase FSL1. FSL1 lacks an active enoyl reductase (ER) domain and biosynthesis of fusarielins relies on the trans-acting enoyl reductase FSL5, before it is released through hydrolysis catalyzed by the thioesterase FSL2 (PubMed:22252016, PubMed:27983606). Fusarielins F, G, and H have a C11=C12 cis double bond and is fully reduced between C10 and C11 and between C12 and C13. FSL3 can be involved in the formation of the C11=C12 cis double bond by moving a hypothetical C10=C11 or C12=C13 trans double bond to form prefusarielin (PubMed:27983606). Prefusarielin is oxygenated at C15 and C16 by FSL4, resulting in fusarielin F, which subsequently is epoxidized into fusarielin G by the same enzyme (PubMed:27983606). The final step in the pathway is a reduction of the carboxylic acid moiety to yield fusarielin H via a still undetermined mechanism (PubMed:27983606).|||Expression is positively regulated by the fusarielin biosynthesis cluster-specific transcription factor FSL7, probably via its binding at the 5'-CGGNNNCCG-3' motif present in the promoter of all the cluster genes.|||Membrane http://togogenome.org/gene/229533:FGSG_12984 ^@ http://purl.uniprot.org/uniprot/I1S809 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_02060 ^@ http://purl.uniprot.org/uniprot/I1REH1 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/229533:FGSG_00291 ^@ http://purl.uniprot.org/uniprot/I1R9X6 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/229533:FGSG_13404 ^@ http://purl.uniprot.org/uniprot/I1S974 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02752 ^@ http://purl.uniprot.org/uniprot/Q4IJ56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/229533:FGSG_07428 ^@ http://purl.uniprot.org/uniprot/V6RGY0 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/229533:FGSG_03929 ^@ http://purl.uniprot.org/uniprot/I1RJB8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00169 ^@ http://purl.uniprot.org/uniprot/A0A1I9EUF3|||http://purl.uniprot.org/uniprot/Q4IRI9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC25 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/229533:FGSG_09240 ^@ http://purl.uniprot.org/uniprot/I1RY12 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/229533:FGSG_01104 ^@ http://purl.uniprot.org/uniprot/I1RC05 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/229533:FGSG_00499 ^@ http://purl.uniprot.org/uniprot/I1RAH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/229533:FGSG_08637 ^@ http://purl.uniprot.org/uniprot/I1RWG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 12 family.|||Component of the SRB8-11 complex, which itself associates with the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_05425 ^@ http://purl.uniprot.org/uniprot/I1RN61 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/229533:FGSG_07470 ^@ http://purl.uniprot.org/uniprot/I1RTG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_06517 ^@ http://purl.uniprot.org/uniprot/I1RR14 ^@ Similarity ^@ Belongs to the IlvD/Edd family. http://togogenome.org/gene/229533:FGSG_04710 ^@ http://purl.uniprot.org/uniprot/I1RLC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06677 ^@ http://purl.uniprot.org/uniprot/I1RRF7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_10126 ^@ http://purl.uniprot.org/uniprot/I1S0A5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/229533:FGSG_11525 ^@ http://purl.uniprot.org/uniprot/I1S3X5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_08451 ^@ http://purl.uniprot.org/uniprot/I1RVZ9 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/229533:FGSG_06635 ^@ http://purl.uniprot.org/uniprot/I1RRB7 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/229533:FGSG_09061 ^@ http://purl.uniprot.org/uniprot/I1RXJ0 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/229533:FGSG_11340 ^@ http://purl.uniprot.org/uniprot/I1S3F9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00182 ^@ http://purl.uniprot.org/uniprot/I1R9N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/229533:FGSG_11654 ^@ http://purl.uniprot.org/uniprot/I1S487 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_06185 ^@ http://purl.uniprot.org/uniprot/I1RQ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_08808 ^@ http://purl.uniprot.org/uniprot/I1RWX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_10087 ^@ http://purl.uniprot.org/uniprot/A0A1I9F466|||http://purl.uniprot.org/uniprot/Q4HY71 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).|||Associates with the nuclear pore complex.|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.|||Cytoplasm|||Nucleus membrane|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nuclear pore complex http://togogenome.org/gene/229533:FGSG_11978 ^@ http://purl.uniprot.org/uniprot/I1S560 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/229533:FGSG_10068 ^@ http://purl.uniprot.org/uniprot/A0A1I9F3I5|||http://purl.uniprot.org/uniprot/Q4HY90 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC4 family.|||Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Nucleus http://togogenome.org/gene/229533:FGSG_08670 ^@ http://purl.uniprot.org/uniprot/I1RWJ8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/229533:FGSG_02944 ^@ http://purl.uniprot.org/uniprot/I1RGS0 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_05509 ^@ http://purl.uniprot.org/uniprot/I1RND6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_01197 ^@ http://purl.uniprot.org/uniprot/I1RC94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pym family.|||Cytoplasm http://togogenome.org/gene/229533:FGSG_00235 ^@ http://purl.uniprot.org/uniprot/I1R9S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_13861 ^@ http://purl.uniprot.org/uniprot/I1SAI0 ^@ Subcellular Location Annotation|||Subunit ^@ Homodimer.|||Secreted http://togogenome.org/gene/229533:FGSG_03714 ^@ http://purl.uniprot.org/uniprot/I1RIS0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/229533:FGSG_06064 ^@ http://purl.uniprot.org/uniprot/I1RPT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX20 family.|||Involved in the assembly of the cytochrome c oxidase complex.|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_00845 ^@ http://purl.uniprot.org/uniprot/I1RBC9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/229533:FGSG_05352 ^@ http://purl.uniprot.org/uniprot/I1RMZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_06413 ^@ http://purl.uniprot.org/uniprot/A0A1I9FX21|||http://purl.uniprot.org/uniprot/Q4I8P5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Membrane|||Mitochondrion inner membrane|||Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. http://togogenome.org/gene/229533:FGSG_02160 ^@ http://purl.uniprot.org/uniprot/V6R0W1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_08428 ^@ http://purl.uniprot.org/uniprot/I1RVY1 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/229533:FGSG_09185 ^@ http://purl.uniprot.org/uniprot/I1RXV9 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/229533:FGSG_10936 ^@ http://purl.uniprot.org/uniprot/Q4HVS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GNT1 family.|||Golgi apparatus membrane|||N-acetylglucosaminyltransferase involved in the Golgi-specific modification of N-linked glycans.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_08915 ^@ http://purl.uniprot.org/uniprot/Q4I1J3 ^@ Domain|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/229533:FGSG_10579 ^@ http://purl.uniprot.org/uniprot/V6RS60 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09651 ^@ http://purl.uniprot.org/uniprot/I1RZ33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07274 ^@ http://purl.uniprot.org/uniprot/I1RSY7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/229533:FGSG_06819 ^@ http://purl.uniprot.org/uniprot/V6REW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/229533:FGSG_04853 ^@ http://purl.uniprot.org/uniprot/I1RLP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0187 family.|||Membrane http://togogenome.org/gene/229533:FGSG_05144 ^@ http://purl.uniprot.org/uniprot/I1RMF5 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/229533:FGSG_03516 ^@ http://purl.uniprot.org/uniprot/I1RI87 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_00876 ^@ http://purl.uniprot.org/uniprot/I1RBF7 ^@ Similarity ^@ Belongs to the PGA52 family. http://togogenome.org/gene/229533:FGSG_12374 ^@ http://purl.uniprot.org/uniprot/I1S6A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/229533:FGSG_09159 ^@ http://purl.uniprot.org/uniprot/I1RXT4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 3 family. http://togogenome.org/gene/229533:FGSG_08674 ^@ http://purl.uniprot.org/uniprot/I1RWK1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBP4 family.|||Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/229533:FGSG_02312 ^@ http://purl.uniprot.org/uniprot/I1RF46 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/229533:FGSG_01174 ^@ http://purl.uniprot.org/uniprot/I1RC71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import.|||Cytoplasm|||Membrane|||Peroxisome membrane http://togogenome.org/gene/229533:FGSG_03244 ^@ http://purl.uniprot.org/uniprot/V6R5T7 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/229533:FGSG_08134 ^@ http://purl.uniprot.org/uniprot/I1RV70 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/229533:FGSG_03624 ^@ http://purl.uniprot.org/uniprot/A0A1I9FAY2|||http://purl.uniprot.org/uniprot/I1RII8 ^@ Activity Regulation|||Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 11 (cellulase G) family.|||Endo-1,4-beta-xylanase involved in the hydrolysis of xylan, a major structural heterogeneous polysaccharide found in plant biomass representing the second most abundant polysaccharide in the biosphere, after cellulose. Plays an important role in causing fusarium head blight (FHB) on cereal crops. Induces cell death and hydrogen peroxide accumulation in infected wheat leaves.|||Expression is under the control of transcription factor XYR1 and highly induced during wheat infection and by xylan.|||Inhibited by the proteinaceous endoxylanase inhibitor I from T.aestivum (TAXI-I).|||Leads to about 40 percent reduction of xylanase activity when grown in culture with xylan as carbon source.|||Secreted http://togogenome.org/gene/229533:FGSG_11596 ^@ http://purl.uniprot.org/uniprot/I1S438 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/229533:FGSG_07267 ^@ http://purl.uniprot.org/uniprot/I1RSY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_01422 ^@ http://purl.uniprot.org/uniprot/I1RCU2 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/229533:FGSG_00076 ^@ http://purl.uniprot.org/uniprot/I1R9E1 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/229533:FGSG_01603 ^@ http://purl.uniprot.org/uniprot/I1RDA9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/229533:FGSG_05331 ^@ http://purl.uniprot.org/uniprot/I1RMX7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03772 ^@ http://purl.uniprot.org/uniprot/I1RIX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_07857 ^@ http://purl.uniprot.org/uniprot/I1RUG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II.|||Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_03952 ^@ http://purl.uniprot.org/uniprot/I1RJD7 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/229533:FGSG_02781 ^@ http://purl.uniprot.org/uniprot/I1RGC2 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/229533:FGSG_13971 ^@ http://purl.uniprot.org/uniprot/I1SAU0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10231 ^@ http://purl.uniprot.org/uniprot/I1S0K2 ^@ Cofactor|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster. http://togogenome.org/gene/229533:FGSG_11865 ^@ http://purl.uniprot.org/uniprot/A0A1I9EX64|||http://purl.uniprot.org/uniprot/Q4IPA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/229533:FGSG_09654 ^@ http://purl.uniprot.org/uniprot/I1RZ35 ^@ Similarity ^@ Belongs to the EIF1AD family. http://togogenome.org/gene/229533:FGSG_00334 ^@ http://purl.uniprot.org/uniprot/I1RA17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10879 ^@ http://purl.uniprot.org/uniprot/I1S293 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/229533:FGSG_06069 ^@ http://purl.uniprot.org/uniprot/I1RPT9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06394 ^@ http://purl.uniprot.org/uniprot/I1RQP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cell membrane|||Membrane http://togogenome.org/gene/229533:FGSG_04403 ^@ http://purl.uniprot.org/uniprot/V6R283 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/229533:FGSG_10512 ^@ http://purl.uniprot.org/uniprot/I1S1B2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS37 family.|||Component of the mitochondrial small ribosomal subunit.|||Involved in mitochondrial genome encoded proteins translation.|||Mitochondrion http://togogenome.org/gene/229533:FGSG_01389 ^@ http://purl.uniprot.org/uniprot/I1RCR3 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/229533:FGSG_08541 ^@ http://purl.uniprot.org/uniprot/I1RW80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_09195 ^@ http://purl.uniprot.org/uniprot/I1RXW9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_01944 ^@ http://purl.uniprot.org/uniprot/I1RE68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02978 ^@ http://purl.uniprot.org/uniprot/V6R7A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_05378 ^@ http://purl.uniprot.org/uniprot/I1RN18 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/229533:FGSG_05274 ^@ http://purl.uniprot.org/uniprot/I1RMS7 ^@ Similarity ^@ Belongs to the MAD2 family. http://togogenome.org/gene/229533:FGSG_04591 ^@ http://purl.uniprot.org/uniprot/I1RL14 ^@ Biotechnology|||Cofactor|||Function|||Similarity ^@ Belongs to the FPP/GGPP synthase family.|||Binds 3 Mg(2+) ions per subunit.|||Diterpenoid pyrones display various biological activities and FDDP E shows anti-HIV activity (PubMed:32286350). FDDP D and FDDP E show also inhibitory activity of 42-mer-amyloid beta aggregation that is involved in the pathogenesis of Alzheimer's disease (PubMed:32286350).|||Geranylgeranyl pyrophosphate synthase; part of the gene cluster that mediates the biosynthesis of diterpenoid pyrones (PubMed:32286350). The first step of the pathway is the synthesis of the alpha-pyrone moiety by the polyketide synthase dpfgA via condensation of one acetyl-CoA starter unit with 3 malonyl-CoA units and 2 methylations (Probable). The alpha-pyrone is then combined with geranylgeranyl pyrophosphate (GGPP) formed by the GGPP synthase dpfgD through the action of the prenyltransferase dpfgC to yield a linear alpha-pyrone diterpenoid (Probable). Subsequent steps in the diterpenoid pyrone biosynthetic pathway involve the decalin core formation, which is initiated by the epoxidation of the C10-C11 olefin by the FAD-dependent oxidoreductase dpfgE, and is followed by a cyclization cascade catalyzed by the terpene cyclase dpfgB (Probable). The short chain dehydrogenase/reductase dpfgG then oxidizes the 8S hydroxy group to a ketone and the short chain dehydrogenase/reductase dpfgH reduces the ketone to the 8R hydroxy group to yield higginsianin B (PubMed:32286350). Higginsianin B is further methylated by the methyltransferase dpfgI to produce the intermediate named FDDP B (PubMed:32286350). The cytochrome P450 monooxygenase dfgpJ then catalyzes a three-step oxidation at C-27 to generate a carboxylic acid as well as C-26 hydroxylation (PubMed:32286350). Finally, methyltransferase dpfgK methylates the carboxylic acid generated by dpfgJ, yielding the final diterpenoid pyrones from the pathway which were named FDDP D and FDDP E (PubMed:32286350). http://togogenome.org/gene/229533:FGSG_05150 ^@ http://purl.uniprot.org/uniprot/Q4ICA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).|||Nucleus http://togogenome.org/gene/229533:FGSG_02315 ^@ http://purl.uniprot.org/uniprot/I1RF49 ^@ Disruption Phenotype|||Domain|||Function|||Similarity ^@ Belongs to the NRP synthetase family.|||Does not affect conidiation but results in reduction of cell surface hydrophobicity.|||NRP synthetases are composed of discrete domains (adenylation (A), thiolation (T) or peptidyl carrier protein (PCP) and condensation (C) domains) which when grouped together are referred to as a single module. Each module is responsible for the recognition (via the A domain) and incorporation of a single amino acid into the growing peptide product. Thus, an NRP synthetase is generally composed of one or more modules and can terminate in a thioesterase domain (TE) that releases the newly synthesized peptide from the enzyme. Occasionally, methyltransferase domains (responsible for amino acid methylation) are present within the NRP synthetase. NRPS4 has the following architecture: A-T-E-C-A-T-C-A-T-E-C-A-T-C-A-T-E-C-T-Ct.|||Nonribosomal peptide synthetase; part of the gene cluster that mediates the biosynthesis of the fusahexin, a cyclic hydrophobic hexapeptide with the amino acid sequence cyclo-(D-Ala-L-Leu-D-allo-Thr-L-Pro-D-Leu-L-Leu) that plays an important role in cell surface hydrophobicity (PubMed:22862913, PubMed:34292732). Fusahexin might also play a role in virulence, sensitivity to osmotic stress and oxidative stress (PubMed:34292732). NRPS4 is the only enzyme within the cluster and its 5 catalytic modules are sufficient to produce fusahexin (PubMed:34292732). The modules 1 to 4 incorporate respectively D-alanine, L-leucine, D-allo-threonine, and L-proline, which is supported by the presence of epimerase domains in modules 1 and 3, which incorporate D-amino acids (PubMed:34292732). The terminal module is responsible for incorporation of the two adjacent leucine units, where the epimerase domain is only used to convert the first unit to D-leucine (PubMed:34292732). The terminal condensation domain (Ct) is involved in cyclization with D-alanine and thereby releasing of fusahexin (PubMed:34292732). http://togogenome.org/gene/229533:FGSG_08944 ^@ http://purl.uniprot.org/uniprot/I1RX90 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/229533:FGSG_07808 ^@ http://purl.uniprot.org/uniprot/I1RUC0 ^@ Similarity ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_05143 ^@ http://purl.uniprot.org/uniprot/I1RMF4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/229533:FGSG_11375 ^@ http://purl.uniprot.org/uniprot/I1S3J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_12884 ^@ http://purl.uniprot.org/uniprot/I1S7Q9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_05183 ^@ http://purl.uniprot.org/uniprot/I1RMJ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol. http://togogenome.org/gene/229533:FGSG_04580 ^@ http://purl.uniprot.org/uniprot/I1RL06 ^@ Disruption Phenotype|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ ABC transporter involved in zearalenone production (PubMed:21833740).|||Belongs to the ABC transporter superfamily. ABCG family. PDR (TC 3.A.1.205) subfamily.|||Cell membrane|||Expression is positively regulated by the zearalenone biosynthesis specific transcription factor ZEB2 (PubMed:21833740).|||Results in the loss of zearalenone production (PubMed:21833740).|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07387 ^@ http://purl.uniprot.org/uniprot/V6RGU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 5 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/229533:FGSG_06160 ^@ http://purl.uniprot.org/uniprot/I1RQ27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_03015 ^@ http://purl.uniprot.org/uniprot/I1RGY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01691 ^@ http://purl.uniprot.org/uniprot/I1RDJ1 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/229533:FGSG_08690 ^@ http://purl.uniprot.org/uniprot/I1RWL5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09110 ^@ http://purl.uniprot.org/uniprot/I1RXN6 ^@ Similarity ^@ Belongs to the PheA/TfdB FAD monooxygenase family.|||Belongs to the paxM FAD-dependent monooxygenase family. http://togogenome.org/gene/229533:FGSG_06318 ^@ http://purl.uniprot.org/uniprot/I1RQH5 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/229533:FGSG_05388 ^@ http://purl.uniprot.org/uniprot/I1RN27 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_12427 ^@ http://purl.uniprot.org/uniprot/I1S6F6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_06644 ^@ http://purl.uniprot.org/uniprot/I1RRC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10669 ^@ http://purl.uniprot.org/uniprot/V6RSF3 ^@ Similarity ^@ In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. http://togogenome.org/gene/229533:FGSG_02513 ^@ http://purl.uniprot.org/uniprot/I1RFN3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10419 ^@ http://purl.uniprot.org/uniprot/A0A1I9F5J2|||http://purl.uniprot.org/uniprot/Q4HX89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_02272 ^@ http://purl.uniprot.org/uniprot/I1RF10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01620 ^@ http://purl.uniprot.org/uniprot/I1RDC6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01024 ^@ http://purl.uniprot.org/uniprot/Q4IP34 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).|||Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_04309 ^@ http://purl.uniprot.org/uniprot/I1RKB2 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/229533:FGSG_02252 ^@ http://purl.uniprot.org/uniprot/I1REZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06397 ^@ http://purl.uniprot.org/uniprot/I1RQQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 61 family.|||Secreted http://togogenome.org/gene/229533:FGSG_10026 ^@ http://purl.uniprot.org/uniprot/I1S014 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_12742 ^@ http://purl.uniprot.org/uniprot/I1S7B9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09125 ^@ http://purl.uniprot.org/uniprot/I1RXQ1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/229533:FGSG_10388 ^@ http://purl.uniprot.org/uniprot/I1S0Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/229533:FGSG_02455 ^@ http://purl.uniprot.org/uniprot/A0A1I9F267|||http://purl.uniprot.org/uniprot/Q4IK03 ^@ Cofactor|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cu(2+) or Zn(2+).|||Mitochondrion inner membrane|||Monomer.|||Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).|||Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS.|||The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria. http://togogenome.org/gene/229533:FGSG_08898 ^@ http://purl.uniprot.org/uniprot/I1RX48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/229533:FGSG_06857 ^@ http://purl.uniprot.org/uniprot/I1RRW0 ^@ Disruption Phenotype|||Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||Impairs hyphal growth, conidiation, conidial germination, and sexual reproduction (PubMed:30603875). Leads to a defect in pathogenicity and production of the mycotoxin deoxynivalenol (DON) (PubMed:30603875). Displays lipid droplet accumulation (PubMed:30603875). Shows reduced tolerance towards oxidative stress (PubMed:30603875). Leads to down-regulation of protein expression levels related to protein biosynthesis, fatty acid metabolism, cell wall synthesis, and oxidation-reduction reactions (PubMed:30603875).|||Ubiquitin-conjugating enzyme E2 that is essential for peroxisome biogenesis and plays a key role in development, pathogenicity, and cell wall integrity (PubMed:30603875). Required for long and very long-chain fatty acid utilization and is involved in lipid droplet accumulation and the elimination of reactive oxygen species (PubMed:30603875). Controls the expression of proteins involved in protein biosynthesis, fatty acid metabolism, cell wall synthesis, oxidation-reduction reactions, as well as of the enzymes involved in the biosynthesis of the mycotoxin deoxynivalenol (DON), including TRI5, TRI6, and TRI10 (PubMed:30603875). http://togogenome.org/gene/229533:FGSG_09843 ^@ http://purl.uniprot.org/uniprot/I1RZJ6 ^@ Similarity ^@ Belongs to the CWC22 family. http://togogenome.org/gene/229533:FGSG_06468 ^@ http://purl.uniprot.org/uniprot/I1RQW7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01868 ^@ http://purl.uniprot.org/uniprot/I1RDZ8 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_08393 ^@ http://purl.uniprot.org/uniprot/I1RVU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_05374 ^@ http://purl.uniprot.org/uniprot/I1RN16 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/229533:FGSG_08253 ^@ http://purl.uniprot.org/uniprot/I1RVH7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 7 (cellulase C) family. http://togogenome.org/gene/229533:FGSG_00778 ^@ http://purl.uniprot.org/uniprot/I1RB71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/229533:FGSG_10766 ^@ http://purl.uniprot.org/uniprot/I1S1Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family.|||Nucleus http://togogenome.org/gene/229533:FGSG_07350 ^@ http://purl.uniprot.org/uniprot/I1RT53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08805 ^@ http://purl.uniprot.org/uniprot/I1RWW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_02594 ^@ http://purl.uniprot.org/uniprot/I1RFV3 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/229533:FGSG_10994 ^@ http://purl.uniprot.org/uniprot/I1S2J8 ^@ Disruption Phenotype|||Function|||Induction|||Subcellular Location Annotation ^@ Expression is induced during infection of coleoptiles of wheat seedlings (PubMed:23266949, PubMed:25333987). The fusaoctaxin A gene cluster is silenced by H3K27 trimethylation by the histone methyltransferase KMT6 (PubMed:31100892).|||Nucleus|||Produces significantly smaller lesions and fewer spikelets with blight symptoms on susceptible wheat cultivars.|||Transcription regulator; part of the Fg3_54/C64 gene cluster that mediates the biosynthesis of the octapeptide fusaoctaxin A, a virulence factor that is required for cell-to-cell invasiveness of plant host (PubMed:30804501). Positively regulates the expression the Fg3_54/C64 gene cluster (PubMed:30804501). http://togogenome.org/gene/229533:FGSG_07853 ^@ http://purl.uniprot.org/uniprot/I1RUG0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/229533:FGSG_03366 ^@ http://purl.uniprot.org/uniprot/I1RHV1 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/229533:FGSG_12461 ^@ http://purl.uniprot.org/uniprot/I1S6J0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 2 family. http://togogenome.org/gene/229533:FGSG_04915 ^@ http://purl.uniprot.org/uniprot/I1RLU6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/229533:FGSG_00333 ^@ http://purl.uniprot.org/uniprot/I1RA16 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06166 ^@ http://purl.uniprot.org/uniprot/I1RQ32 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/229533:FGSG_11037 ^@ http://purl.uniprot.org/uniprot/I1S2N7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 12 (cellulase H) family. http://togogenome.org/gene/229533:FGSG_08468 ^@ http://purl.uniprot.org/uniprot/I1RW16 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/229533:FGSG_01007 ^@ http://purl.uniprot.org/uniprot/A0A1I9EXD2|||http://purl.uniprot.org/uniprot/Q4IP51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA.|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/229533:FGSG_07376 ^@ http://purl.uniprot.org/uniprot/I1RT77 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/229533:FGSG_13834 ^@ http://purl.uniprot.org/uniprot/I1SAF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polysaccharide lyase 1 family.|||Secreted http://togogenome.org/gene/229533:FGSG_03616 ^@ http://purl.uniprot.org/uniprot/I1RII3 ^@ Similarity ^@ Belongs to the RNase T2 family.|||Belongs to the oxygen-dependent FAD-linked oxidoreductase family. http://togogenome.org/gene/229533:FGSG_06231 ^@ http://purl.uniprot.org/uniprot/I1RQ92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_13640 ^@ http://purl.uniprot.org/uniprot/I1S9V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IML1 family.|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_07360 ^@ http://purl.uniprot.org/uniprot/I1RT63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05318 ^@ http://purl.uniprot.org/uniprot/I1RMW5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03946 ^@ http://purl.uniprot.org/uniprot/I1RJD3 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/229533:FGSG_09788 ^@ http://purl.uniprot.org/uniprot/I1RZE9 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/229533:FGSG_05702 ^@ http://purl.uniprot.org/uniprot/I1RNW0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Homododecamer. Adopts a ring-like structure, composed of an arrangement of two hexameric rings stacked on top of one another.|||Is involved in the catabolism of quinate. Allows the utilization of quinate as carbon source via the beta-ketoadipate pathway. http://togogenome.org/gene/229533:FGSG_09579 ^@ http://purl.uniprot.org/uniprot/I1RYW8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/229533:FGSG_12599 ^@ http://purl.uniprot.org/uniprot/I1S6X6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/229533:FGSG_09870 ^@ http://purl.uniprot.org/uniprot/I1RZM1 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/229533:FGSG_05926 ^@ http://purl.uniprot.org/uniprot/I1RPF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08528 ^@ http://purl.uniprot.org/uniprot/V6RS91 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysH subfamily. http://togogenome.org/gene/229533:FGSG_01408 ^@ http://purl.uniprot.org/uniprot/A0A1I9EYP9|||http://purl.uniprot.org/uniprot/Q4IN00 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. FKBP2 subfamily.|||Endoplasmic reticulum|||Inhibited by both FK506 and rapamycin.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/229533:FGSG_03814 ^@ http://purl.uniprot.org/uniprot/I1RJ15 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_09701 ^@ http://purl.uniprot.org/uniprot/I1RZ75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_00520 ^@ http://purl.uniprot.org/uniprot/I1RAJ0 ^@ Caution|||Function|||Similarity ^@ Belongs to the PLPL family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Probable lipid hydrolase. http://togogenome.org/gene/229533:FGSG_08655 ^@ http://purl.uniprot.org/uniprot/I1RWI5 ^@ Similarity ^@ Belongs to the eIF-1A family. http://togogenome.org/gene/229533:FGSG_08706 ^@ http://purl.uniprot.org/uniprot/I1RWN0 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/229533:FGSG_05117 ^@ http://purl.uniprot.org/uniprot/I1RMC8 ^@ Similarity ^@ Belongs to the CCDC124 family. http://togogenome.org/gene/229533:FGSG_01447 ^@ http://purl.uniprot.org/uniprot/I1RCW4 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/229533:FGSG_08064 ^@ http://purl.uniprot.org/uniprot/I1RV04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_09531 ^@ http://purl.uniprot.org/uniprot/I1RYS2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/229533:FGSG_01465 ^@ http://purl.uniprot.org/uniprot/V6QWZ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. http://togogenome.org/gene/229533:FGSG_12704 ^@ http://purl.uniprot.org/uniprot/I1S781 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_10940 ^@ http://purl.uniprot.org/uniprot/I1S2E8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||Required for pre-18S rRNA processing. May bind microtubules.|||nucleolus http://togogenome.org/gene/229533:FGSG_01295 ^@ http://purl.uniprot.org/uniprot/I1RCI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/229533:FGSG_08458 ^@ http://purl.uniprot.org/uniprot/I1RW06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/229533:FGSG_05709 ^@ http://purl.uniprot.org/uniprot/I1RNW6 ^@ Similarity ^@ In the 2nd section; belongs to the type-I 3-dehydroquinase family.|||In the N-terminal section; belongs to the shikimate kinase family. http://togogenome.org/gene/229533:FGSG_04454 ^@ http://purl.uniprot.org/uniprot/I1RKP1 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/229533:FGSG_11218 ^@ http://purl.uniprot.org/uniprot/I1S353 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08634 ^@ http://purl.uniprot.org/uniprot/I1RWG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_08586 ^@ http://purl.uniprot.org/uniprot/I1RWC2 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/229533:FGSG_11084 ^@ http://purl.uniprot.org/uniprot/I1S2T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_05284 ^@ http://purl.uniprot.org/uniprot/I1RMT6 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/229533:FGSG_07802 ^@ http://purl.uniprot.org/uniprot/I1RUB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01910 ^@ http://purl.uniprot.org/uniprot/I1RE37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Nucleus http://togogenome.org/gene/229533:FGSG_01900 ^@ http://purl.uniprot.org/uniprot/I1RE27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/229533:FGSG_09339 ^@ http://purl.uniprot.org/uniprot/I1RY98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MEF2 family.|||Nucleus http://togogenome.org/gene/229533:FGSG_09778 ^@ http://purl.uniprot.org/uniprot/I1RZD9 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/229533:FGSG_07509 ^@ http://purl.uniprot.org/uniprot/I1RTK0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01364 ^@ http://purl.uniprot.org/uniprot/I1RCP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel alpha-1 subunit (TC 1.A.1.11) family.|||Membrane http://togogenome.org/gene/229533:FGSG_00538 ^@ http://purl.uniprot.org/uniprot/I1RAK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/229533:FGSG_02714 ^@ http://purl.uniprot.org/uniprot/I1RG64 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/229533:FGSG_04196 ^@ http://purl.uniprot.org/uniprot/V6R3V4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_09065 ^@ http://purl.uniprot.org/uniprot/I1RXJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/229533:FGSG_00139 ^@ http://purl.uniprot.org/uniprot/V6QU99 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/229533:FGSG_01373 ^@ http://purl.uniprot.org/uniprot/I1RCP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_01132 ^@ http://purl.uniprot.org/uniprot/A0A1I9EXS5|||http://purl.uniprot.org/uniprot/Q4INS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/229533:FGSG_09321 ^@ http://purl.uniprot.org/uniprot/I1RY81 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA acetyltransferase; part of the first module of ergosterol biosynthesis pathway that includes the early steps of the pathway, conserved across all eukaryotes, and which results in the formation of mevalonate from acetyl-coenzyme A (acetyl-CoA) (By similarity). ERG10B catalyzes the formation of acetoacetyl-CoA from acetyl-CoA (By similarity). The first module starts with the action of the cytosolic acetyl-CoA acetyltransferase ERG10B that catalyzes the formation of acetoacetyl-CoA. The hydroxymethylglutaryl-CoA synthases ERG13 then condenses acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. The rate-limiting step of the early module is the reduction to mevalonate by the 3-hydroxy-3-methylglutaryl-coenzyme A (HMG-CoA) reductases HMG1 (Probable).|||Belongs to the thiolase-like superfamily. Thiolase family.|||Expression is regulated by the Zn(2)-C6 fungal-type transcription factor FgSR which binds directly to the promoter.|||Homotetramer.|||cytosol http://togogenome.org/gene/229533:FGSG_07555 ^@ http://purl.uniprot.org/uniprot/I1RTP2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PLPL family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lipid hydrolase.|||Membrane|||Probable lipid hydrolase. http://togogenome.org/gene/229533:FGSG_00045 ^@ http://purl.uniprot.org/uniprot/I1R9B2 ^@ Function|||Similarity ^@ AB hydrolase superfamily protein; part of the gene cluster that mediates the biosynthesis of gramillins A and B, bicyclic lipopeptides that induce cell death in maize leaves but not in wheat leaves (PubMed:30395461). The nonribosomal peptide synthetase GRA1 incorporates respectively a glutamic adic (Glu), a leucine (Leu), a serine (Ser), a hydroxyglutamine (HOGln), a 2-amino decanoic acid, and 2 cysteins (CysB and CysA) (Probable). The biosynthesis of 2-amino decanoic acid incorporated in gramillins could be initiated by a fatty acid synthase composed of the alpha and beta subunits FGSG_00036 and FGSG_11656 (Probable). The cytochrome P450 monooxygenase FGSG_15680 could hydroxylate the fatty acid chain (Probable). Subsequent oxidation to the ketone by the oxidoreductase FGSG_00048 and transamination by aminotransferase FGSG_00049 could form 2-amino-decanoic acid (Probable). On the other hand, FGSG_15680 could also be responsible for the HO-modified glutamine at the gamma-position (Probable). Whether hydroxylation occurs on the fully assembled product or on the Gln residue prior to assembly into the gramillins requires further proof (Probable). The thioredoxin FGSG_00043 could also be required for the disulfide-bond formation between CysA and CysB (Probable). The specific involvement of the remaining proteins from the cluster is more difficult to discern, but could have broader regulatory (FGSG_00040 and FGSG_11657) or enzymatic functions (FGSG_00044 and FGSG_00045) (Probable). The final C-domain of GRA1 does not possess the expected sequence of a termination CT domain, often implicated in macrocyclization and release of a cyclopeptidein fungal NRPs; and the thioesterase FGSG_00047 may act in concert with the terminal C-domain of GRA1 to catalyze the formation of the macrocyclic anhydride and release of the products (Probable).|||Belongs to the AB hydrolase superfamily. http://togogenome.org/gene/229533:FGSG_13281 ^@ http://purl.uniprot.org/uniprot/I1S8V3 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/229533:FGSG_06849 ^@ http://purl.uniprot.org/uniprot/A0A1I9FN07|||http://purl.uniprot.org/uniprot/Q4I7F9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved in mRNA splicing. May destabilize the U1/5'-splice site duplex to permit an effective competition for the 5'-splice site by the U6 snRNA, resulting in the switch between U1 and U6 at the 5'-splice site. May also act to unwind the U4/U6 base-pairing interaction in the U4/U6/U5 snRNP, facilitating the first covalent step of splicing (By similarity).|||Belongs to the DEAD box helicase family.|||Belongs to the DEAD box helicase family. DDX23/PRP28 subfamily.|||Component of the U5 snRNP complex.|||Cytoplasm|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/229533:FGSG_10027 ^@ http://purl.uniprot.org/uniprot/I1S015 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_03965 ^@ http://purl.uniprot.org/uniprot/I1RJE9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. http://togogenome.org/gene/229533:FGSG_00969 ^@ http://purl.uniprot.org/uniprot/I1RBN8 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/229533:FGSG_06659 ^@ http://purl.uniprot.org/uniprot/I1RRE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease. http://togogenome.org/gene/229533:FGSG_04157 ^@ http://purl.uniprot.org/uniprot/I1RJX3 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/229533:FGSG_02016 ^@ http://purl.uniprot.org/uniprot/I1REC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/229533:FGSG_09736 ^@ http://purl.uniprot.org/uniprot/I1RZA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/229533:FGSG_10394 ^@ http://purl.uniprot.org/uniprot/V6RSW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/229533:FGSG_06495 ^@ http://purl.uniprot.org/uniprot/I1RQZ3 ^@ Function|||Similarity ^@ Belongs to the flavokinase family.|||Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme. http://togogenome.org/gene/229533:FGSG_00649 ^@ http://purl.uniprot.org/uniprot/I1RAW0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/229533:FGSG_09807 ^@ http://purl.uniprot.org/uniprot/I1RZG7 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/229533:FGSG_09564 ^@ http://purl.uniprot.org/uniprot/I1RYV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSH4 family.|||Components of the endosome-vacuole trafficking pathway that regulates nutrient transport. May be involved in processes which determine whether plasma membrane proteins are degraded or routed to the plasma membrane.|||Endosome membrane|||Membrane|||Vacuole membrane http://togogenome.org/gene/229533:FGSG_13446 ^@ http://purl.uniprot.org/uniprot/I1S9B6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferroportin (FP) (TC 2.A.100) family. SLC40A subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in iron transport and iron homeostasis.|||Membrane http://togogenome.org/gene/229533:FGSG_09912 ^@ http://purl.uniprot.org/uniprot/I1RZR0 ^@ Similarity ^@ Belongs to the Cdt1 family.