http://togogenome.org/gene/284811:AGOS_AEL332W ^@ http://purl.uniprot.org/uniprot/Q758T4 ^@ Similarity ^@ Belongs to the FUN14 family. http://togogenome.org/gene/284811:AGOS_AAR093C ^@ http://purl.uniprot.org/uniprot/Q75EI6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). Required for proper protein synthesis within the mitochondrion.|||Belongs to the GatF family.|||Mitochondrion inner membrane|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/284811:AGOS_AER282W ^@ http://purl.uniprot.org/uniprot/Q756H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR508W ^@ http://purl.uniprot.org/uniprot/Q752R5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR365C ^@ http://purl.uniprot.org/uniprot/Q753E9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL015C ^@ http://purl.uniprot.org/uniprot/Q75AD2 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. http://togogenome.org/gene/284811:AGOS_ACR257C ^@ http://purl.uniprot.org/uniprot/Q9P8V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family.|||Cell membrane http://togogenome.org/gene/284811:AGOS_AFR659W ^@ http://purl.uniprot.org/uniprot/Q752B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the DnaJ family.|||Cytoplasm|||Involved in pre-mRNA splicing. May be involved in endoplasmic reticulum-associated protein degradation (ERAD) and required for growth at low and high temperatures (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR124C ^@ http://purl.uniprot.org/uniprot/Q75EF7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/284811:AGOS_AER443W ^@ http://purl.uniprot.org/uniprot/Q755S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER059C ^@ http://purl.uniprot.org/uniprot/Q757F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ART10 family.|||Cytoplasm|||May regulate endocytosis by recruiting RSP5 ubiquitin ligase activity to specific plasma membrane proteins in response to extracellular stimuli. http://togogenome.org/gene/284811:AGOS_ADR338C ^@ http://purl.uniprot.org/uniprot/Q759D9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR001W ^@ http://purl.uniprot.org/uniprot/Q75DL7 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/284811:AGOS_ADL254W ^@ http://purl.uniprot.org/uniprot/Q75B31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AEL139W ^@ http://purl.uniprot.org/uniprot/Q757Z9 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/284811:AGOS_AER146C ^@ http://purl.uniprot.org/uniprot/Q756V5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/284811:AGOS_ACR278W ^@ http://purl.uniprot.org/uniprot/Q75BJ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR169C ^@ http://purl.uniprot.org/uniprot/Q75EA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AMI006W ^@ http://purl.uniprot.org/uniprot/Q75G39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACR268C ^@ http://purl.uniprot.org/uniprot/Q75BK3 ^@ Similarity ^@ Belongs to the malate synthase family. http://togogenome.org/gene/284811:AGOS_AFL183C ^@ http://purl.uniprot.org/uniprot/Q755Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ADR084C ^@ http://purl.uniprot.org/uniprot/Q75A35 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/284811:AGOS_ADR082C ^@ http://purl.uniprot.org/uniprot/Q75A37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Regulates the cell cycle in a nutrient dependent manner. http://togogenome.org/gene/284811:AGOS_ADL274W ^@ http://purl.uniprot.org/uniprot/Q75B51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB2 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL127W ^@ http://purl.uniprot.org/uniprot/Q75CP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR237W ^@ http://purl.uniprot.org/uniprot/Q754I0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL205C ^@ http://purl.uniprot.org/uniprot/Q75AX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGL335W ^@ http://purl.uniprot.org/uniprot/Q751N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Homodimer.|||Mitochondrion inner membrane|||Performs an essential function in the generation of cytoplasmic iron-sulfur proteins by mediating the ATP-dependent export of Fe/S cluster precursors synthesized by NFS1 and other mitochondrial proteins (By similarity). Hydrolyzes ATP (By similarity). Binds glutathione and may function by transporting a glutathione-conjugated iron-sulfur compound (By similarity). http://togogenome.org/gene/284811:AGOS_AER451W ^@ http://purl.uniprot.org/uniprot/Q755R7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NMT1/THI5 family.|||Homodimer.|||Responsible for the formation of the pyrimidine heterocycle in the thiamine biosynthesis pathway. Catalyzes the formation of hydroxymethylpyrimidine phosphate (HMP-P) from histidine and pyridoxal phosphate (PLP). The protein uses PLP and the active site histidine to form HMP-P, generating an inactive enzyme. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. http://togogenome.org/gene/284811:AGOS_ACR020C ^@ http://purl.uniprot.org/uniprot/Q75C96 ^@ Similarity ^@ Belongs to the MYBBP1A family. http://togogenome.org/gene/284811:AGOS_ACR192C ^@ http://purl.uniprot.org/uniprot/Q75BS9 ^@ Similarity ^@ Belongs to the WD repeat mio family. http://togogenome.org/gene/284811:AGOS_ABL195C ^@ http://purl.uniprot.org/uniprot/Q8NJR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GST superfamily.|||Homodimer.|||Plays an important role in the cellular response to the nitrogen source. URE2 gene plays a major part in the repression of GLN1 and GDH2 genes by glutamine, and is required for the inactivation of glutamine synthetase. URE2 gene product may catalytically inactivate GLN3 in response to an increase in the intracellular concentration of glutamine (By similarity). http://togogenome.org/gene/284811:AGOS_ABL077W ^@ http://purl.uniprot.org/uniprot/Q75DV0 ^@ Similarity ^@ Belongs to the nitrite and sulfite reductase 4Fe-4S domain family. http://togogenome.org/gene/284811:AGOS_AAL132C ^@ http://purl.uniprot.org/uniprot/Q75F60 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/284811:AGOS_AGR152W ^@ http://purl.uniprot.org/uniprot/Q74ZP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACR068W ^@ http://purl.uniprot.org/uniprot/Q75C49 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/284811:AGOS_AFR688C ^@ http://purl.uniprot.org/uniprot/Q751Y7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/284811:AGOS_ADR014W ^@ http://purl.uniprot.org/uniprot/Q75AA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM21 family.|||Involved in mitochondrial migration along actin filaments.|||actin patch http://togogenome.org/gene/284811:AGOS_AAL168C ^@ http://purl.uniprot.org/uniprot/Q75FA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX16 family.|||Mitochondrion inner membrane|||Required for the assembly of the mitochondrial respiratory chain complex IV (CIV), also known as cytochrome c oxidase. May participate in merging the COX1 and COX2 assembly lines. http://togogenome.org/gene/284811:AGOS_AAR098W ^@ http://purl.uniprot.org/uniprot/Q75EI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR311C ^@ http://purl.uniprot.org/uniprot/Q759G5 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AEL219W ^@ http://purl.uniprot.org/uniprot/Q758I1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAR032W ^@ http://purl.uniprot.org/uniprot/Q75EP7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR152CA ^@ http://purl.uniprot.org/uniprot/Q759X0 ^@ Similarity ^@ Belongs to the sulfiredoxin family. http://togogenome.org/gene/284811:AGOS_ADL210W ^@ http://purl.uniprot.org/uniprot/Q75AY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Membrane http://togogenome.org/gene/284811:AGOS_AAR066W ^@ http://purl.uniprot.org/uniprot/Q75EL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR309W ^@ http://purl.uniprot.org/uniprot/Q759G7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.|||Catalytic component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.|||Component of the SWR1 chromatin-remodeling complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR459W ^@ http://purl.uniprot.org/uniprot/Q752W4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/284811:AGOS_AFR147C ^@ http://purl.uniprot.org/uniprot/Q754C3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR369C ^@ http://purl.uniprot.org/uniprot/Q759A8 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/284811:AGOS_ADR107W ^@ http://purl.uniprot.org/uniprot/Q75A20 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. Homocitrate synthase LYS20/LYS21 subfamily.|||Catalyzes the aldol-type condensation of 2-oxoglutarate with acetyl-CoA to yield homocitrate. Carries out the first step of the alpha-aminoadipate (AAA) lysine biosynthesis pathway. http://togogenome.org/gene/284811:AGOS_AGR223W ^@ http://purl.uniprot.org/uniprot/Q74ZH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GDE1 family.|||Cytoplasm|||Glycerophosphocholine glycerophosphodiesterase responsible for the hydrolysis of intracellular glycerophosphocholine into glycerol-phosphate and choline. The choline is used for phosphatidyl-choline synthesis. Required for utilization of glycerophosphocholine as phosphate source. http://togogenome.org/gene/284811:AGOS_AGL121W ^@ http://purl.uniprot.org/uniprot/Q750R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGL260W ^@ http://purl.uniprot.org/uniprot/Q751G6 ^@ Similarity ^@ Belongs to the alkaline phosphatase family. http://togogenome.org/gene/284811:AGOS_AEL152W ^@ http://purl.uniprot.org/uniprot/Q758E0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/284811:AGOS_AAL079C ^@ http://purl.uniprot.org/uniprot/Q75F07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AEL099W ^@ http://purl.uniprot.org/uniprot/Q757W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL007C ^@ http://purl.uniprot.org/uniprot/Q75AC4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL193W ^@ http://purl.uniprot.org/uniprot/Q758F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284811:AGOS_AER245C ^@ http://purl.uniprot.org/uniprot/Q756K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCP1 family.|||Cytoplasm|||Involved in nuclear export, actin cytoskeleton organization and vesicular transport.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL175W ^@ http://purl.uniprot.org/uniprot/Q750W4 ^@ Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AER336C ^@ http://purl.uniprot.org/uniprot/Q756D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ABR008C ^@ http://purl.uniprot.org/uniprot/Q75DS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the STAM family.|||Component of the ESCRT-0 complex composed of HSE1 and VPS27.|||Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB).|||Endosome membrane http://togogenome.org/gene/284811:AGOS_AGR385C ^@ http://purl.uniprot.org/uniprot/Q74Z21 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/284811:AGOS_AFR593C ^@ http://purl.uniprot.org/uniprot/Q752Z5 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/284811:AGOS_AAL166C ^@ http://purl.uniprot.org/uniprot/Q75FA5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MMM1 family.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Homodimer. Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.|||The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers. http://togogenome.org/gene/284811:AGOS_AGR132W ^@ http://purl.uniprot.org/uniprot/Q74ZR6 ^@ Similarity ^@ In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/284811:AGOS_ABR031C ^@ http://purl.uniprot.org/uniprot/Q75DJ3 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/284811:AGOS_AGR161C ^@ http://purl.uniprot.org/uniprot/Q74ZN7 ^@ Similarity ^@ Belongs to the SPT2 family. http://togogenome.org/gene/284811:AGOS_AER049W ^@ http://purl.uniprot.org/uniprot/Q757G4 ^@ Similarity ^@ Belongs to the VAC14 family. http://togogenome.org/gene/284811:AGOS_AGR140C ^@ http://purl.uniprot.org/uniprot/Q74ZQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SHU2 family.|||Nucleus|||Plays a role in a RAD51/RAD54-dependent homologous recombination repair (HRR) pathway to repair MMS-induced lesions during S-phase. Required for error-free repair of spontaneous and induced DNA lesions to protect the genome from mutation (By similarity). http://togogenome.org/gene/284811:AGOS_ADR021W ^@ http://purl.uniprot.org/uniprot/Q75A97 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acireductone dioxygenase (ARD) family.|||Binds either 1 Fe or Ni cation per monomer. Iron-binding promotes an acireductone dioxygenase reaction producing 2-keto-4-methylthiobutyrate, while nickel-binding promotes an acireductone dioxygenase reaction producing 3-(methylsulfanyl)propanoate.|||Catalyzes 2 different reactions between oxygen and the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene) depending upon the metal bound in the active site. Fe-containing acireductone dioxygenase (Fe-ARD) produces formate and 2-keto-4-methylthiobutyrate (KMTB), the alpha-ketoacid precursor of methionine in the methionine recycle pathway. Ni-containing acireductone dioxygenase (Ni-ARD) produces methylthiopropionate, carbon monoxide and formate, and does not lie on the methionine recycle pathway.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR076C ^@ http://purl.uniprot.org/uniprot/Q75A43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).|||spindle pole body http://togogenome.org/gene/284811:AGOS_AFL016C ^@ http://purl.uniprot.org/uniprot/Q754T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL124C ^@ http://purl.uniprot.org/uniprot/Q75AP4 ^@ Similarity ^@ Belongs to the UQCRH/QCR6 family. http://togogenome.org/gene/284811:AGOS_AGL073W ^@ http://purl.uniprot.org/uniprot/Q750M9 ^@ Cofactor|||PTM|||Similarity ^@ Belongs to the copper/topaquinone oxidase family.|||Contains 1 topaquinone per subunit.|||Topaquinone (TPQ) is generated by copper-dependent autoxidation of a specific tyrosyl residue. http://togogenome.org/gene/284811:AGOS_AER075W ^@ http://purl.uniprot.org/uniprot/Q757D8 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/284811:AGOS_ACL054W ^@ http://purl.uniprot.org/uniprot/Q75CH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. APG1/unc-51/ULK1 subfamily.|||Cytoplasm|||Homodimer. Forms a ternary complex with ATG13 and ATG17.|||Preautophagosomal structure membrane|||Serine/threonine protein kinase involved in the cytoplasm to vacuole transport (Cvt) and found to be essential in autophagy, where it is required for the formation of autophagosomes. Involved in the clearance of protein aggregates which cannot be efficiently cleared by the proteasome. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Also involved in endoplasmic reticulum-specific autophagic process, in selective removal of ER-associated degradation (ERAD) substrates. Plays a key role in ATG9 and ATG23 cycling through the pre-autophagosomal structure and is necessary to promote ATG18 binding to ATG9 through phosphorylation of ATG9. Catalyzes phosphorylation of ATG4, decreasing the interaction between ATG4 and ATG8 and impairing deconjugation of PE-conjugated forms of ATG8. http://togogenome.org/gene/284811:AGOS_ABL203W ^@ http://purl.uniprot.org/uniprot/Q75E73 ^@ Similarity ^@ Belongs to the peptidase S8 family. Furin subfamily. http://togogenome.org/gene/284811:AGOS_AFL082W ^@ http://purl.uniprot.org/uniprot/Q755A7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/284811:AGOS_AAL113W ^@ http://purl.uniprot.org/uniprot/Q75F41 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_ADL066C ^@ http://purl.uniprot.org/uniprot/O94198 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Catalyzes the formation of succinate and glyoxylate from isocitrate, a key step of the glyoxylate cycle, which operates as an anaplerotic route for replenishing the tricarboxylic acid cycle. Required for growth on ethanol or acetate, but dispensable when fermentable carbon sources are available. Acts also on 2-methylisocitrate.|||Glyoxysome|||Homotetramer. http://togogenome.org/gene/284811:AGOS_ADL354W ^@ http://purl.uniprot.org/uniprot/Q75BC1 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AAR028W ^@ http://purl.uniprot.org/uniprot/Q75EQ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Mitochondrion inner membrane|||Probably involved in the biogenesis of the COX complex. http://togogenome.org/gene/284811:AGOS_AER366W ^@ http://purl.uniprot.org/uniprot/Q756A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL095W ^@ http://purl.uniprot.org/uniprot/Q75F23 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of a pre-mRNA cleavage factor complex. Interacts directly with PCF11.|||May lack the polyribonucleotide 5'-hydroxyl-kinase and polynucleotide 5'-hydroxyl-kinase activities that are characteristic of the human ortholog.|||Nucleus|||Required for endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation. http://togogenome.org/gene/284811:AGOS_AEL059W ^@ http://purl.uniprot.org/uniprot/Q757S1 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. http://togogenome.org/gene/284811:AGOS_AER409C ^@ http://purl.uniprot.org/uniprot/Q755V9 ^@ Function|||Subcellular Location Annotation ^@ Plays a role in starvation-induced autophagy. Involved in mitophagy. Functions with ATG17 and ATG29 at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. May be involved in microtubule function, such as chromosome segregation and karyogamy (By similarity).|||Preautophagosomal structure|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AGL177C ^@ http://purl.uniprot.org/uniprot/Q750W6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/284811:AGOS_ADR055C ^@ http://purl.uniprot.org/uniprot/Q75A63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAMP4 family.|||Endoplasmic reticulum membrane|||May interact with target proteins during translocation into the lumen of the endoplasmic reticulum. May protect unfolded target proteins against degradation and facilitate correct glycosylation. http://togogenome.org/gene/284811:AGOS_AFR278W ^@ http://purl.uniprot.org/uniprot/Q753N4 ^@ Similarity ^@ Belongs to the proteasome subunit S14 family. http://togogenome.org/gene/284811:AGOS_ACR255C ^@ http://purl.uniprot.org/uniprot/Q75BL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm|||Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Has a physiological role leading to 18S rRNA stability (By similarity). http://togogenome.org/gene/284811:AGOS_ABR014W ^@ http://purl.uniprot.org/uniprot/Q75DK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Cytoplasm|||MAP4K component of the MAPK pathway required for the mating pheromone response and the regulation of cell polarity and cell cycle. Phosphorylates histone H2B to form H2BS10ph (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR258W ^@ http://purl.uniprot.org/uniprot/Q753R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR143C ^@ http://purl.uniprot.org/uniprot/Q75D81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EFG1 family.|||Involved in rRNA processing.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFL021C ^@ http://purl.uniprot.org/uniprot/Q754U2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DAD3 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AAR080W ^@ http://purl.uniprot.org/uniprot/Q75EJ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Membrane|||Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AER294C ^@ http://purl.uniprot.org/uniprot/Q756H2 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Cytoplasm|||Homodimer.|||Mg(2+) is required for catalysis and for stabilizing the dimer. http://togogenome.org/gene/284811:AGOS_AAL041C ^@ http://purl.uniprot.org/uniprot/Q75EW9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||Interacts with the SSU processome.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AGR191W ^@ http://purl.uniprot.org/uniprot/Q74ZK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL008W ^@ http://purl.uniprot.org/uniprot/Q750G1 ^@ Similarity ^@ Belongs to the patched family. http://togogenome.org/gene/284811:AGOS_AFR516W ^@ http://purl.uniprot.org/uniprot/Q752Q7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/284811:AGOS_AER024W ^@ http://purl.uniprot.org/uniprot/Q757I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the REXO4 family.|||Exoribonuclease involved in ribosome biosynthesis. Involved in the processing of ITS1, the internal transcribed spacer localized between the 18S and 5.8S rRNAs (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL198W ^@ http://purl.uniprot.org/uniprot/Q755L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR132W ^@ http://purl.uniprot.org/uniprot/Q759Z1 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/284811:AGOS_ADR292W ^@ http://purl.uniprot.org/uniprot/Q759H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/284811:AGOS_ACL106C ^@ http://purl.uniprot.org/uniprot/Q75CM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL011C ^@ http://purl.uniprot.org/uniprot/Q75DM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/284811:AGOS_ADR285W ^@ http://purl.uniprot.org/uniprot/Q759J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors GET1 and GET2, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the GET1-GET2 receptor, and returning it to the cytosol to initiate a new round of targeting. Cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. Involved in low-level resistance to the oxyanions arsenite and arsenate, and in heat tolerance.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Golgi apparatus|||Homodimer. Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer. Interacts with the chloride channel protein GEF1. http://togogenome.org/gene/284811:AGOS_AAR107W ^@ http://purl.uniprot.org/uniprot/Q75EH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IWS1 family.|||Nucleus|||Transcription factor involved in RNA polymerase II transcription regulation. May function in both SPT15/TBP post-recruitment and recruitment steps of transcription (By similarity). http://togogenome.org/gene/284811:AGOS_AFR441C ^@ http://purl.uniprot.org/uniprot/Q752Y2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AER262C ^@ http://purl.uniprot.org/uniprot/Q756W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR148C ^@ http://purl.uniprot.org/uniprot/Q74ZQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR007C ^@ http://purl.uniprot.org/uniprot/Q750E8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAR125C ^@ http://purl.uniprot.org/uniprot/Q75EF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR411C ^@ http://purl.uniprot.org/uniprot/Q753B3 ^@ Similarity ^@ Belongs to the VPS29 family. http://togogenome.org/gene/284811:AGOS_AGL266C ^@ http://purl.uniprot.org/uniprot/Q751H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ABR056C ^@ http://purl.uniprot.org/uniprot/Q75DH0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. http://togogenome.org/gene/284811:AGOS_AER079C ^@ http://purl.uniprot.org/uniprot/Q757D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BLOC1S1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).|||Endosome http://togogenome.org/gene/284811:AGOS_AEL287C ^@ http://purl.uniprot.org/uniprot/Q758V4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/284811:AGOS_AEL001C ^@ http://purl.uniprot.org/uniprot/Q8J1F7 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/284811:AGOS_ADR293CA ^@ http://purl.uniprot.org/uniprot/Q759H1 ^@ Similarity ^@ Belongs to the SWI5/SAE3 family. http://togogenome.org/gene/284811:AGOS_ADR143W ^@ http://purl.uniprot.org/uniprot/Q759Y0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAR5 family.|||Endoplasmic reticulum membrane|||Nucleus membrane|||Required for nuclear membrane fusion during karyogamy. http://togogenome.org/gene/284811:AGOS_AFR422W ^@ http://purl.uniprot.org/uniprot/Q753A2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/284811:AGOS_AAL019W ^@ http://purl.uniprot.org/uniprot/Q75EU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL033W ^@ http://purl.uniprot.org/uniprot/Q75EW1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM5 / TYW2 family.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/284811:AGOS_AFR300C ^@ http://purl.uniprot.org/uniprot/Q753L2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SKG1 family.|||Bud membrane|||Cell membrane|||Plays a role in cell wall integrity. Affects the cell wall polymer composition in the growing region of the cell (By similarity). http://togogenome.org/gene/284811:AGOS_AEL067W ^@ http://purl.uniprot.org/uniprot/Q757S9 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/284811:AGOS_ADL209C ^@ http://purl.uniprot.org/uniprot/Q75AX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP25 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3.|||DEAD-box RNA helicase-like protein required for pre-18S rRNA processing, specifically at sites A0, A1, and A2.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABR041C ^@ http://purl.uniprot.org/uniprot/Q75DI4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/284811:AGOS_ABL174C ^@ http://purl.uniprot.org/uniprot/Q75E44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family. Ssb-type Hsp70 subfamily.|||Binds to ribosomes. Binds close to the ribosomal tunnel exit via contacts with both ribosomal proteins and rRNA. Directly interacts with nascent polypeptides. This interaction is dependent on the ribosome-associated complex (RAC). Interacts with SSE1. Interacts with FES1.|||Cytoplasm|||Ribosome-bound, Hsp70-type chaperone that assists in the cotranslational folding of newly synthesized proteins in the cytosol. Stimulates folding by interacting with nascent chains, binding to short, largely hydrophobic sequences exposed by unfolded proteins, thereby stabilizing longer, more slowly translated, and aggregation-prone nascent polypeptides and domains that cannot fold stably until fully synthesized. The Hsp70-protein substrate interaction depends on ATP-binding and on allosteric regulation between the NBD and the SBD. The ATP-bound state is characterized by a fast exchange rate of substrate (low affinity state), while in the ADP-bound state exchange is much slower (high affinity state). During the Hsp70 cycle, the chaperone switches between the ATP-bound state (open conformation) and the ADP-bound state (closed conformation) by major conformational rearrangements involving mainly the lid domain. Ssb cooperates with a specific Hsp40/Hsp70 co-chaperone termed the ribosome-associated complex (RAC), which stimulates the ATPase activity of the ribosome-associated pool of Ssbs and switches it to the high affinity substrate binding state. Hsp110 chaperone SSE1 and FES1 act as nucleotide exchange factors that cause substrate release. http://togogenome.org/gene/284811:AGOS_ADR063W ^@ http://purl.uniprot.org/uniprot/Q75A56 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DP1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Oligomer.|||Required to generate and maintain the structure of the tubular endoplasmic reticulum network and the vacuole. Induces high curvature in membranes and causes membrane tubule formation. Involved in membrane/vesicle trafficking.|||The short lumenal loops between transmembrane domains 1 and 2 and between transmembrane domains 3 and 4 may impart a wedge-like configuration, thus deforming membranes. http://togogenome.org/gene/284811:AGOS_ADR146C ^@ http://purl.uniprot.org/uniprot/Q759X7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/284811:AGOS_AER004W ^@ http://purl.uniprot.org/uniprot/Q757K8 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/284811:AGOS_AGR267W ^@ http://purl.uniprot.org/uniprot/Q74ZD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Required for transport from the ER to the Golgi complex. http://togogenome.org/gene/284811:AGOS_AFR251C ^@ http://purl.uniprot.org/uniprot/Q753S5 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/284811:AGOS_ADR094W ^@ http://purl.uniprot.org/uniprot/Q75A26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/284811:AGOS_ABR139W ^@ http://purl.uniprot.org/uniprot/Q75D85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER136W ^@ http://purl.uniprot.org/uniprot/Q756X8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/284811:AGOS_AGL120W ^@ http://purl.uniprot.org/uniprot/Q750R2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284811:AGOS_AGR238C ^@ http://purl.uniprot.org/uniprot/Q74ZG9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL139W ^@ http://purl.uniprot.org/uniprot/Q750S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR465C ^@ http://purl.uniprot.org/uniprot/Q752V8 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/284811:AGOS_AFR056W ^@ http://purl.uniprot.org/uniprot/Q754L6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPC7 RNA polymerase subunit family.|||Component of the RNA polymerase III (Pol III) complex.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR510W ^@ http://purl.uniprot.org/uniprot/Q752R3 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/284811:AGOS_AEL048W ^@ http://purl.uniprot.org/uniprot/Q757R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Functions in both vacuole inheritance and protein targeting from the cytoplasm to vacuole.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGR195W ^@ http://purl.uniprot.org/uniprot/Q74ZK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER455C ^@ http://purl.uniprot.org/uniprot/Q755R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL061W ^@ http://purl.uniprot.org/uniprot/Q750L8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).|||Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity). http://togogenome.org/gene/284811:AGOS_AFR482W ^@ http://purl.uniprot.org/uniprot/Q752U1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the myo-inositol oxygenase family.|||Binds 2 iron ions per subunit.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGR348W ^@ http://purl.uniprot.org/uniprot/Q74Z58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP52 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ABR134C ^@ http://purl.uniprot.org/uniprot/Q75D90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1C family.|||Nuclear serine protease which mediates apoptosis.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR379C ^@ http://purl.uniprot.org/uniprot/Q758Z8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/284811:AGOS_AAR128W ^@ http://purl.uniprot.org/uniprot/Q75EF3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/284811:AGOS_ADR119W ^@ http://purl.uniprot.org/uniprot/Q75A08 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/284811:AGOS_AER269C ^@ http://purl.uniprot.org/uniprot/Q756J2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL292C ^@ http://purl.uniprot.org/uniprot/Q75B64 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AFR723C ^@ http://purl.uniprot.org/uniprot/Q751V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPS2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR137C ^@ http://purl.uniprot.org/uniprot/Q754D3 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/284811:AGOS_AFR126W ^@ http://purl.uniprot.org/uniprot/Q754E4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR569W ^@ http://purl.uniprot.org/uniprot/Q752K5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/284811:AGOS_AFL040W ^@ http://purl.uniprot.org/uniprot/Q754V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL366W ^@ http://purl.uniprot.org/uniprot/Q75BD2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/284811:AGOS_ABL104C ^@ http://purl.uniprot.org/uniprot/Q75DX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Catalyzes the synthesis of 5-aminolevulinate (ALA) from succinyl-CoA and glycine, the first and rate-limiting step in heme biosynthesis.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AAL076W ^@ http://purl.uniprot.org/uniprot/Q75F04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/284811:AGOS_ACL139W ^@ http://purl.uniprot.org/uniprot/Q75CQ8 ^@ Function|||Subcellular Location Annotation ^@ Is required for the uptake of Fe(3+) ions. May participate in the transport of electrons from cytoplasm to an extracellular substrate (Fe(3+) ion) via FAD and heme intermediates. Involved in iron homeostasis (By similarity).|||Membrane http://togogenome.org/gene/284811:AGOS_AGR005C ^@ http://purl.uniprot.org/uniprot/Q750F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YPI1 family.|||Nucleus|||Regulator of type 1 phosphatases which maintains protein phosphatase activity under strict control. http://togogenome.org/gene/284811:AGOS_ABR012C ^@ http://purl.uniprot.org/uniprot/Q75DK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the pre-60S ribosomal particle.|||Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome assembly machinery. Nuclear paralog of the ribosomal protein P0, it binds pre-60S subunits at an early stage of assembly in the nucleolus, and is replaced by P0 in cytoplasmic pre-60S subunits and mature 80S ribosomes.|||Cytoplasm|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR026W ^@ http://purl.uniprot.org/uniprot/Q75A92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL232C ^@ http://purl.uniprot.org/uniprot/Q751D8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the diphosphomevalonate decarboxylase family.|||Diphosphomevalonate decarboxylase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway (By similarity). The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins (By similarity). Activity by the mevalonate kinase ERG12 first converts mevalonate into 5-phosphomevalonate. 5-phosphomevalonate is then further converted to 5-diphosphomevalonate by the phosphomevalonate kinase ERG8 (By similarity). The diphosphomevalonate decarboxylase MVD1/ERG19 then produces isopentenyl diphosphate (By similarity). The isopentenyl-diphosphate delta-isomerase IDI1 then catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its highly electrophilic allylic isomer, dimethylallyl diphosphate (DMAPP) (By similarity). Finally the farnesyl diphosphate synthase ERG20 catalyzes the sequential condensation of isopentenyl pyrophosphate with dimethylallyl pyrophosphate, and then with the resultant geranylpyrophosphate to the ultimate product farnesyl pyrophosphate (By similarity).|||Homodimer. http://togogenome.org/gene/284811:AGOS_AGR130W ^@ http://purl.uniprot.org/uniprot/Q74ZR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/284811:AGOS_ADR035C ^@ http://purl.uniprot.org/uniprot/Q75A83 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM MRD1 family.|||Involved in pre-rRNA processing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR189C ^@ http://purl.uniprot.org/uniprot/Q75BT2 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/284811:AGOS_AFR618C ^@ http://purl.uniprot.org/uniprot/Q752F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR407C ^@ http://purl.uniprot.org/uniprot/Q74Z00 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_AFR643C ^@ http://purl.uniprot.org/uniprot/Q752D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AEL342W ^@ http://purl.uniprot.org/uniprot/Q758U4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/284811:AGOS_ABL111C ^@ http://purl.uniprot.org/uniprot/Q75DY4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/284811:AGOS_ADR155C ^@ http://purl.uniprot.org/uniprot/Q759W7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates directly with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM10 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/284811:AGOS_ACL016C ^@ http://purl.uniprot.org/uniprot/Q75CC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TAF4 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID. Binding of TFIID to a promoter (with or without TATA element) is the initial step in pre-initiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation by TAF1), facilitation of DNA opening and initiation of transcription (By similarity).|||Nucleus|||The 1.2 MDa TFIID complex is composed of TATA binding protein (TBP) and the 14 TBP-associated factors. http://togogenome.org/gene/284811:AGOS_AGL365C ^@ http://purl.uniprot.org/uniprot/Q751Q4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family. http://togogenome.org/gene/284811:AGOS_AGR231C ^@ http://purl.uniprot.org/uniprot/Q74ZH6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AER232C ^@ http://purl.uniprot.org/uniprot/Q756M2 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/284811:AGOS_ACR179C ^@ http://purl.uniprot.org/uniprot/Q75BU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN12 family.|||Component of a COP9 signalosome-like (CSN) complex.|||Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AER397C ^@ http://purl.uniprot.org/uniprot/Q755X1 ^@ Similarity ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family. http://togogenome.org/gene/284811:AGOS_ACR022W ^@ http://purl.uniprot.org/uniprot/Q75C94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGR022C ^@ http://purl.uniprot.org/uniprot/Q750D3 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/284811:AGOS_AER165W ^@ http://purl.uniprot.org/uniprot/Q756T8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/284811:AGOS_AAL071C ^@ http://purl.uniprot.org/uniprot/Q75EZ9 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AGR292C ^@ http://purl.uniprot.org/uniprot/Q74ZF9 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/284811:AGOS_ABR051C ^@ http://purl.uniprot.org/uniprot/Q75DH5 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/284811:AGOS_AFL005W ^@ http://purl.uniprot.org/uniprot/Q754S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL383W ^@ http://purl.uniprot.org/uniprot/Q75BE7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat ASA1 family.|||Component of the ASTRA chromatin remodeling machinery complex.|||Component of the ASTRA complex involved in chromatin remodeling.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL056C ^@ http://purl.uniprot.org/uniprot/Q75CH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/284811:AGOS_AER015C ^@ http://purl.uniprot.org/uniprot/Q757J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR457W ^@ http://purl.uniprot.org/uniprot/Q752W6 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/284811:AGOS_AAR062C ^@ http://purl.uniprot.org/uniprot/Q75EL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL050W ^@ http://purl.uniprot.org/uniprot/Q75DR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP25 family.|||Mitochondrion inner membrane|||Probable mitochondrial mRNA stabilization factor. http://togogenome.org/gene/284811:AGOS_AFR488W ^@ http://purl.uniprot.org/uniprot/Q752T5 ^@ Similarity ^@ Belongs to the Fmt family. http://togogenome.org/gene/284811:AGOS_AFR649W ^@ http://purl.uniprot.org/uniprot/Q752C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIL4 subfamily.|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/284811:AGOS_ACR038W ^@ http://purl.uniprot.org/uniprot/Q75C78 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen|||Probably plays a role in facilitating the assembly of multimeric protein complexes inside the ER. Is required for secretory polypeptide translocation. May physically associate with SEC63 protein in the endoplasmic reticulum and this interaction may be regulated by ATP hydrolysis.|||The chaperone activity is regulated by ATP-induced allosteric coupling of the nucleotide-binding (NBD) and substrate-binding (SBD) domains. In the ADP-bound and nucleotide-free (apo) states, the two domains have little interaction. In contrast, in the ATP-bound state the two domains are tightly coupled, which results in drastically accelerated kinetics in both binding and release of polypeptide substrates. J domain-containing co-chaperones stimulate the ATPase activity and are required for efficient substrate recognition. http://togogenome.org/gene/284811:AGOS_AGR147W ^@ http://purl.uniprot.org/uniprot/Q74ZQ1 ^@ Similarity ^@ Belongs to the COG3 family. http://togogenome.org/gene/284811:AGOS_ACR013C ^@ http://purl.uniprot.org/uniprot/Q75CE3 ^@ Similarity ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily. http://togogenome.org/gene/284811:AGOS_AGR271C ^@ http://purl.uniprot.org/uniprot/Q74ZC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR691W ^@ http://purl.uniprot.org/uniprot/Q751Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ABR086W ^@ http://purl.uniprot.org/uniprot/Q75DE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family. IMP2 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR678C ^@ http://purl.uniprot.org/uniprot/Q751Z7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Endoplasmic reticulum membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR103W ^@ http://purl.uniprot.org/uniprot/Q74ZU5 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/284811:AGOS_ADL374W ^@ http://purl.uniprot.org/uniprot/Q75BD8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DIM1 family.|||Component of the 25S [U4/U6.U5] tri-snRNP.|||Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL028W ^@ http://purl.uniprot.org/uniprot/Q75EV6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Cytoplasm|||Monomer.|||Ribosome-dependent ATPase that functions in cytoplasmic translation elongation (By similarity). Required for the ATP-dependent release of deacylated tRNA from the ribosomal E-site during protein biosynthesis (By similarity). Stimulates the eEF1A-dependent binding of aminoacyl-tRNA to the ribosomal A-site, which has reduced affinity for tRNA as long as the E-site is occupied (By similarity). http://togogenome.org/gene/284811:AGOS_AGR381C ^@ http://purl.uniprot.org/uniprot/Q74Z25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-14 family.|||Component of the peroxisomal translocation machinery.|||Peroxisome membrane http://togogenome.org/gene/284811:AGOS_ACR156W ^@ http://purl.uniprot.org/uniprot/Q75BW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Cytoplasm|||Rnase which modulates cell survival under stress conditions. Released from the vacuole to the cytoplasm during stress to promote tRNA and rRNA cleavage and to activate separately a downstream pathway that promotes cell death. Involved in cell size, vacuolar morphology and growth at high temperatures and high salt concentration (By similarity).|||Vacuole lumen http://togogenome.org/gene/284811:AGOS_AER279W ^@ http://purl.uniprot.org/uniprot/Q756I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CUE1 family.|||Component of the endoplasmic reticulum-associated protein degradation (ERAD) pathway. Recruits the soluble ubiquitin-conjugating enzyme UBC7 to the cytoplasmic face of the endoplasmic reticulum membrane where it functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Targets the E2 conjugating enzyme UBC7 to the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains, and to the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).|||Endoplasmic reticulum membrane|||Forms a heterodimer with UBC7. http://togogenome.org/gene/284811:AGOS_AFR452C ^@ http://purl.uniprot.org/uniprot/Q752X1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/284811:AGOS_ABR126W ^@ http://purl.uniprot.org/uniprot/Q75D98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR199C ^@ http://purl.uniprot.org/uniprot/Q75D23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX20 family.|||Involved in the assembly of the cytochrome c oxidase complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER459W ^@ http://purl.uniprot.org/uniprot/Q755Q9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_AAR180C ^@ http://purl.uniprot.org/uniprot/Q75E97 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX15/PRP43 sub-subfamily. http://togogenome.org/gene/284811:AGOS_AER442W ^@ http://purl.uniprot.org/uniprot/Q755S6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM34 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM34 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10.|||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.|||Mitochondrion outer membrane|||The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers. http://togogenome.org/gene/284811:AGOS_ABL033C ^@ http://purl.uniprot.org/uniprot/Q75DQ0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AFR435W ^@ http://purl.uniprot.org/uniprot/Q752Y6 ^@ Similarity ^@ Belongs to the glycosyltransferase 32 family. http://togogenome.org/gene/284811:AGOS_AER373C ^@ http://purl.uniprot.org/uniprot/Q755Z4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AFR045W ^@ http://purl.uniprot.org/uniprot/Q754M7 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/284811:AGOS_AFR680W ^@ http://purl.uniprot.org/uniprot/Q751Z5 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/284811:AGOS_AEL211W ^@ http://purl.uniprot.org/uniprot/Q758H3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/284811:AGOS_AAR065C ^@ http://purl.uniprot.org/uniprot/Q75EL4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/284811:AGOS_AAL125W ^@ http://purl.uniprot.org/uniprot/Q75F53 ^@ Function|||Subcellular Location Annotation ^@ Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL066C ^@ http://purl.uniprot.org/uniprot/Q754Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LCL3 family.|||Membrane|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR230W ^@ http://purl.uniprot.org/uniprot/Q74ZH7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||GTPase-activating protein (GAP) for CDC42 and less efficiently for RHO1. Negative regulator of the pheromone-response pathway through the STE20 protein kinase (By similarity). http://togogenome.org/gene/284811:AGOS_AEL154C ^@ http://purl.uniprot.org/uniprot/Q758A6 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/284811:AGOS_AER263C ^@ http://purl.uniprot.org/uniprot/Q756W4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AEL310C ^@ http://purl.uniprot.org/uniprot/Q758R3 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/284811:AGOS_AGR309C ^@ http://purl.uniprot.org/uniprot/Q74Z94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/284811:AGOS_ADL026W ^@ http://purl.uniprot.org/uniprot/Q75AE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER123W ^@ http://purl.uniprot.org/uniprot/Q756Z1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284811:AGOS_AFR526C ^@ http://purl.uniprot.org/uniprot/Q752P7 ^@ Function|||Similarity ^@ Belongs to the MBF1 family.|||Transcriptional coactivator that stimulates transcriptional activity by bridging regulatory proteins and TBP, thereby recruiting TBP to promoters occupied by DNA-binding regulators. http://togogenome.org/gene/284811:AGOS_ADR280W ^@ http://purl.uniprot.org/uniprot/Q759J7 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/284811:AGOS_AGL329C ^@ http://purl.uniprot.org/uniprot/Q751M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LIP1 family.|||Component of the ceramide synthase complex required for synthesis of ceramides.|||Component of the ceramide synthase complex.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AFR590W ^@ http://purl.uniprot.org/uniprot/Q752I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE9/KNH1 family.|||Involved in cell wall beta(1->6) glucan synthesis.|||cell wall http://togogenome.org/gene/284811:AGOS_AFR576C ^@ http://purl.uniprot.org/uniprot/Q752J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT4 family.|||Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity).|||centromere http://togogenome.org/gene/284811:AGOS_AFR466C ^@ http://purl.uniprot.org/uniprot/Q752V7 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/284811:AGOS_ADL216C ^@ http://purl.uniprot.org/uniprot/Q75AY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD type 2 subfamily.|||Nucleus|||Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. http://togogenome.org/gene/284811:AGOS_ACR092C ^@ http://purl.uniprot.org/uniprot/Q75C25 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/284811:AGOS_AFR486C ^@ http://purl.uniprot.org/uniprot/Q752T7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 3 family.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL283W ^@ http://purl.uniprot.org/uniprot/Q75BH1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/284811:AGOS_AGL130C ^@ http://purl.uniprot.org/uniprot/Q750R9 ^@ Function|||Similarity ^@ Belongs to the SEC10 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/284811:AGOS_ABR062W ^@ http://purl.uniprot.org/uniprot/Q75DG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BLI1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).|||Endosome http://togogenome.org/gene/284811:AGOS_ADR283W ^@ http://purl.uniprot.org/uniprot/Q759J4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/284811:AGOS_AEL291C ^@ http://purl.uniprot.org/uniprot/Q758P4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR020W ^@ http://purl.uniprot.org/uniprot/Q75DK1 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Required for transport of secretory proteins from the Golgi complex. Catalyzes the transfer of phosphatidylinositol and phosphatidylcholine between membranes in vitro (By similarity). http://togogenome.org/gene/284811:AGOS_AER173C ^@ http://purl.uniprot.org/uniprot/Q756T0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_ABR214C ^@ http://purl.uniprot.org/uniprot/Q75D08 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/284811:AGOS_ADL186C ^@ http://purl.uniprot.org/uniprot/Q75AV6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat RTC1 family.|||May be involved in a process influencing telomere capping.|||Vacuole http://togogenome.org/gene/284811:AGOS_ADL202C ^@ http://purl.uniprot.org/uniprot/Q757N1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).|||Belongs to the histone H3 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).|||Nucleus|||Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5 and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80. http://togogenome.org/gene/284811:AGOS_ADR321C ^@ http://purl.uniprot.org/uniprot/Q759F5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL178C ^@ http://purl.uniprot.org/uniprot/Q758D0 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/284811:AGOS_AGR278C ^@ http://purl.uniprot.org/uniprot/Q74ZC1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX56/DBP9 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL017W ^@ http://purl.uniprot.org/uniprot/Q750H0 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/284811:AGOS_AEL252C ^@ http://purl.uniprot.org/uniprot/Q758L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL210C ^@ http://purl.uniprot.org/uniprot/Q758H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACR104C ^@ http://purl.uniprot.org/uniprot/Q75C13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACL006W ^@ http://purl.uniprot.org/uniprot/Q75CB5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily. http://togogenome.org/gene/284811:AGOS_ABL081W ^@ http://purl.uniprot.org/uniprot/Q75DV4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HIR3 family.|||Has a role in a nucleosome assembly pathway that is required for the integrity of heterochromatin and proper chromosome segregation.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR068W ^@ http://purl.uniprot.org/uniprot/Q75A51 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AFR609C ^@ http://purl.uniprot.org/uniprot/Q752G7 ^@ Function|||Similarity ^@ Belongs to the LplA family.|||Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/284811:AGOS_AFL104W ^@ http://purl.uniprot.org/uniprot/Q755C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACR292W ^@ http://purl.uniprot.org/uniprot/Q75BH9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LTE1 family.|||Bud|||Cytoplasm|||GDP-GTP exchange factor component of the mitotic exit network (MEN). Fine-tunes the timing of the mitotic exit and couples this event with cytokinesis. May also be involved in proprotein-processing in the secretory pathway (By similarity). http://togogenome.org/gene/284811:AGOS_ADL120C ^@ http://purl.uniprot.org/uniprot/Q75B05 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/284811:AGOS_AFR413C ^@ http://purl.uniprot.org/uniprot/Q753B1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/284811:AGOS_AFR113W ^@ http://purl.uniprot.org/uniprot/Q754F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER003C ^@ http://purl.uniprot.org/uniprot/Q757K9 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/284811:AGOS_AEL060C ^@ http://purl.uniprot.org/uniprot/Q757S2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR236W ^@ http://purl.uniprot.org/uniprot/Q74ZH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL060W ^@ http://purl.uniprot.org/uniprot/Q75EY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFT1 family.|||Nucleus|||RNA-binding component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. Involved in poly(A) site recognition. May be involved in coupling transcription termination and mRNA 3'-end formation (By similarity). http://togogenome.org/gene/284811:AGOS_AEL131C ^@ http://purl.uniprot.org/uniprot/Q757Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 4 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR035W ^@ http://purl.uniprot.org/uniprot/Q754N7 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. COT1 subfamily.|||Protein kinase that seems to play a role in the regulation of cell morphogenesis and proliferation. http://togogenome.org/gene/284811:AGOS_AAR157C ^@ http://purl.uniprot.org/uniprot/Q75EB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AGL091W ^@ http://purl.uniprot.org/uniprot/Q751B6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR359C ^@ http://purl.uniprot.org/uniprot/Q753F5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAD-like hydrolase superfamily. MasA/MtnC family.|||Bifunctional enzyme that catalyzes the enolization of 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P) into the intermediate 2-hydroxy-3-keto-5-methylthiopentenyl-1-phosphate (HK-MTPenyl-1-P), which is then dephosphorylated to form the acireductone 1,2-dihydroxy-3-keto-5-methylthiopentene (DHK-MTPene).|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL151W ^@ http://purl.uniprot.org/uniprot/Q75AS1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxin-21 family.|||Interacts with PEX7.|||Mediates peroxisomal import of proteins containing a C-terminal PTS2-type peroxisomal targeting signal via its interaction with PEX7 (By similarity). Interaction with PEX7 only takes place when PEX7 is associated with cargo proteins containing a PTS2 peroxisomal targeting signal (By similarity). PEX7 along with PTS2-containing cargo proteins are then translocated through the PEX13-PEX14 docking complex together with PEX21 (By similarity).|||Monoubiquitinated at Cys-4; acts as a signal for PEX21 extraction and is required for proper export from peroxisomes and recycling.|||Peroxisome|||cytosol http://togogenome.org/gene/284811:AGOS_AAL009C ^@ http://purl.uniprot.org/uniprot/Q75ET3 ^@ Similarity ^@ Belongs to the WD repeat LST8 family. http://togogenome.org/gene/284811:AGOS_AFR338W ^@ http://purl.uniprot.org/uniprot/Q753H4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Assembly factor required for Rieske Fe-S protein RIP1 incorporation into the cytochrome b-c1 (CIII) complex. Functions as a chaperone, binding to this subunit within the mitochondrial matrix and stabilizing it prior to its translocation and insertion into the late CIII dimeric intermediate within the mitochondrial inner membrane. Modulates the mitochondrial matrix zinc pool (By similarity).|||Belongs to the complex I LYR family. MZM1 subfamily.|||Interacts with RIP1.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AER361C ^@ http://purl.uniprot.org/uniprot/Q756A6 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/284811:AGOS_AER295C ^@ http://purl.uniprot.org/uniprot/Q756H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/284811:AGOS_ADL323C ^@ http://purl.uniprot.org/uniprot/Q75B93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL084W ^@ http://purl.uniprot.org/uniprot/Q755A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPS2 family.|||Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication.|||Nucleus membrane|||spindle pole body http://togogenome.org/gene/284811:AGOS_AFR643WA ^@ http://purl.uniprot.org/uniprot/Q755R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACL027C ^@ http://purl.uniprot.org/uniprot/Q75CD6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of a COP9 signalosome-like (CSN) complex.|||Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes The CSN complex is involved in the regulation of the mating pheromone response. PCI8 may also be involved in transcriptional and translational control (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR063C ^@ http://purl.uniprot.org/uniprot/Q75DG3 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family. http://togogenome.org/gene/284811:AGOS_AFR521W ^@ http://purl.uniprot.org/uniprot/Q752Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins. http://togogenome.org/gene/284811:AGOS_AEL114C ^@ http://purl.uniprot.org/uniprot/Q757X6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL005C ^@ http://purl.uniprot.org/uniprot/Q75AC2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VAB2 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) composed of at least BLI1, BLS1, CNL1, KXD1, SNN1 and VAB2.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.|||Cytoplasm|||Cytoplasmic vesicle|||Vacuole http://togogenome.org/gene/284811:AGOS_AFR339W ^@ http://purl.uniprot.org/uniprot/Q753H3 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Catalyzes the last step of tRNA splicing, the transfer of the splice junction 2'-phosphate from ligated tRNA to NAD to produce ADP-ribose 1''-2'' cyclic phosphate. http://togogenome.org/gene/284811:AGOS_AFR523C ^@ http://purl.uniprot.org/uniprot/Q752Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CybS family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR405C ^@ http://purl.uniprot.org/uniprot/Q74Z02 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/284811:AGOS_AGR325C ^@ http://purl.uniprot.org/uniprot/Q74Z81 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS1 family.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum. Dispensable for SPC enzymatic activity.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AGR265W ^@ http://purl.uniprot.org/uniprot/Q74ZD4 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/284811:AGOS_AGR120C ^@ http://purl.uniprot.org/uniprot/Q74ZS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR402C ^@ http://purl.uniprot.org/uniprot/Q753Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR248W ^@ http://purl.uniprot.org/uniprot/Q75BM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL191W ^@ http://purl.uniprot.org/uniprot/Q75AW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AER122C ^@ http://purl.uniprot.org/uniprot/Q756Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIF1/spd1 family.|||Cytoplasm|||Mediates the nuclear localization of the ribonucleotide reductase.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR232C ^@ http://purl.uniprot.org/uniprot/Q75BN9 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/284811:AGOS_AAL135C ^@ http://purl.uniprot.org/uniprot/Q75F63 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL161W ^@ http://purl.uniprot.org/uniprot/Q75FA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/284811:AGOS_AGR168W ^@ http://purl.uniprot.org/uniprot/Q74ZN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/284811:AGOS_AAL062W ^@ http://purl.uniprot.org/uniprot/Q75EZ0 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/284811:AGOS_AAR051C ^@ http://purl.uniprot.org/uniprot/Q75EM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER253W ^@ http://purl.uniprot.org/uniprot/P62499 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DSS1/SEM1 family.|||Part of the 26S proteasome.|||Subunit of the 26S proteasome which plays a role in ubiquitin-dependent proteolysis. http://togogenome.org/gene/284811:AGOS_AAR009W ^@ http://purl.uniprot.org/uniprot/Q75ES0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ADR215C ^@ http://purl.uniprot.org/uniprot/Q759Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL195C ^@ http://purl.uniprot.org/uniprot/Q750Y4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR194C ^@ http://purl.uniprot.org/uniprot/Q75BS7 ^@ Function|||Similarity ^@ Belongs to the WD repeat DDB2/WDR76 family.|||DNA-binding protein that binds to both single- and double-stranded DNA. Binds preferentially to UV-damaged DNA. May be involved in DNA-metabolic processes. http://togogenome.org/gene/284811:AGOS_AAL073W ^@ http://purl.uniprot.org/uniprot/Q75F01 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/284811:AGOS_ACR173W ^@ http://purl.uniprot.org/uniprot/Q75BU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/284811:AGOS_AGL358C ^@ http://purl.uniprot.org/uniprot/Q751P7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YME2 family.|||Mitochondrion inner membrane|||Plays a role in maintaining the mitochondrial genome and in controlling the mtDNA escape. Involved in the regulation of mtDNA nucleotide structure and number. May have a dispensable role in early maturation of pre-rRNA (By similarity). http://togogenome.org/gene/284811:AGOS_AFR183C ^@ http://purl.uniprot.org/uniprot/Q753Y9 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/284811:AGOS_AGL155W ^@ http://purl.uniprot.org/uniprot/Q750U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Functions as a component of the DNA-binding general transcription factor complex TFIID and the transcription regulatory histone acetylation (HAT) complexes SAGA and SLIK. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification (histone acetylation), facilitation of DNA opening and initiation of transcription. SAGA is required for recruitment of the basal transcription machinery. SLIK is proposed to have partly overlapping functions with SAGA.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL340W ^@ http://purl.uniprot.org/uniprot/Q75BA7 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/284811:AGOS_ABR114C ^@ http://purl.uniprot.org/uniprot/Q75DB0 ^@ Similarity ^@ Belongs to the oxoprolinase family. http://togogenome.org/gene/284811:AGOS_ABR087C ^@ http://purl.uniprot.org/uniprot/Q75DE0 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/284811:AGOS_ABL206C ^@ http://purl.uniprot.org/uniprot/Q75E77 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis. http://togogenome.org/gene/284811:AGOS_AAR146W ^@ http://purl.uniprot.org/uniprot/Q75EC8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/284811:AGOS_ADR165C ^@ http://purl.uniprot.org/uniprot/Q759V7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/284811:AGOS_AGR180W ^@ http://purl.uniprot.org/uniprot/Q74ZL8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AFR362C ^@ http://purl.uniprot.org/uniprot/Q753F2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/284811:AGOS_ACL121C ^@ http://purl.uniprot.org/uniprot/Q75CP0 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/284811:AGOS_AFR429C ^@ http://purl.uniprot.org/uniprot/Q752Z2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC3 family.|||Endoplasmic reticulum membrane|||Membrane|||The EMC seems to be required for efficient folding of proteins in the endoplasmic reticulum (ER). http://togogenome.org/gene/284811:AGOS_AFR043W ^@ http://purl.uniprot.org/uniprot/Q754M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AER084W ^@ http://purl.uniprot.org/uniprot/Q757C9 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/284811:AGOS_ABL127W ^@ http://purl.uniprot.org/uniprot/Q75E00 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/284811:AGOS_AFR089W ^@ http://purl.uniprot.org/uniprot/Q754I5 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/284811:AGOS_AGR284W ^@ http://purl.uniprot.org/uniprot/Q74ZB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM7 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein methyltransferase that trimethylates the N-terminal glycine 'Gly-2' of elongation factor 1-alpha, before also catalyzing the mono- and dimethylation of 'Lys-3'. http://togogenome.org/gene/284811:AGOS_AGR277W ^@ http://purl.uniprot.org/uniprot/Q74ZC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/284811:AGOS_ABL014C ^@ http://purl.uniprot.org/uniprot/Q75DN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR112C ^@ http://purl.uniprot.org/uniprot/Q75C07 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NifU family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the core Fe-S cluster (ISC) assembly machinery.|||Mitochondrion matrix|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH. http://togogenome.org/gene/284811:AGOS_AER422C ^@ http://purl.uniprot.org/uniprot/Q755U6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/284811:AGOS_AER026C ^@ http://purl.uniprot.org/uniprot/Q757I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BMT2 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of an adenine present in helix 65 in 25S rRNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR228C ^@ http://purl.uniprot.org/uniprot/Q74ZW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL080W ^@ http://purl.uniprot.org/uniprot/Q75AK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL263W ^@ http://purl.uniprot.org/uniprot/Q75B40 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/284811:AGOS_AAR031W ^@ http://purl.uniprot.org/uniprot/Q75EP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Plays a role in maintenance of chromatin structure during RNA polymerase II transcription elongation thereby repressing transcription initiation from cryptic promoters. Mediates the reassembly of nucleosomes onto the promoters of at least a selected set of genes during repression; the nucleosome reassembly is essential for transcriptional repression (By similarity). http://togogenome.org/gene/284811:AGOS_AER087C ^@ http://purl.uniprot.org/uniprot/Q757C6 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/284811:AGOS_ACL064C ^@ http://purl.uniprot.org/uniprot/Q75CI3 ^@ Function|||Similarity ^@ Belongs to the VPS13 family.|||Mediates the transfer of lipids between membranes at organelle contact sites. May play a role in mitochondrial lipid homeostasis. http://togogenome.org/gene/284811:AGOS_ABL094W ^@ http://purl.uniprot.org/uniprot/Q75DW7 ^@ Similarity ^@ Belongs to the pex2/pex10/pex12 family. http://togogenome.org/gene/284811:AGOS_ACR291C ^@ http://purl.uniprot.org/uniprot/Q75BI0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB19 family.|||Cytoplasm|||Golgi apparatus|||May be involved in protein-linked oligosaccharide phosphorylation. http://togogenome.org/gene/284811:AGOS_AER108C ^@ http://purl.uniprot.org/uniprot/Q757A5 ^@ Cofactor|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cu(2+) or Zn(2+).|||Mitochondrion inner membrane|||Monomer.|||Required for the import and folding of small cysteine-containing proteins (small Tim) in the mitochondrial intermembrane space (IMS). Forms a redox cycle with ERV1 that involves a disulfide relay system. Precursor proteins to be imported into the IMS are translocated in their reduced form into the mitochondria. The oxidized form of MIA40 forms a transient intermolecular disulfide bridge with the reduced precursor protein, resulting in oxidation of the precursor protein that now contains an intramolecular disulfide bond and is able to undergo folding in the IMS (By similarity).|||The CHCH domain contains a conserved twin Cys-X(9)-Cys motif which is required for import and stability of MIA40 in mitochondria. http://togogenome.org/gene/284811:AGOS_ADL310W ^@ http://purl.uniprot.org/uniprot/Q75B82 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NHP6 family.|||Chromosome|||DNA-binding protein that induces severe bending of DNA. Required for DNA-binding by the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. Also augments the fidelity of transcription by RNA polymerase III independently of any role in the FACT complex (By similarity).|||Nucleus|||Weakly associates with the stable SPT16-POB3 heterodimer to form the FACT complex. http://togogenome.org/gene/284811:AGOS_AEL292W ^@ http://purl.uniprot.org/uniprot/Q758P5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL118C ^@ http://purl.uniprot.org/uniprot/Q75AP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tim44 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL024C ^@ http://purl.uniprot.org/uniprot/Q75AE1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily.|||Interacts with the U3 snoRNA and is associated with the 90S and 40S pre-ribosomes.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFL020W ^@ http://purl.uniprot.org/uniprot/Q754U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL045W ^@ http://purl.uniprot.org/uniprot/Q75CG4 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGL090W ^@ http://purl.uniprot.org/uniprot/Q750P0 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/284811:AGOS_AGR345C ^@ http://purl.uniprot.org/uniprot/Q74Z61 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/284811:AGOS_AER342C ^@ http://purl.uniprot.org/uniprot/Q756C5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the palA/RIM20 family.|||Interacts with RIM101 by binding to its two YPX[LI] motifs.|||Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. May act as a scaffold protein that recruits the calpain-like protease RIM13 via VPS32 to its substrate RIM101 (By similarity). http://togogenome.org/gene/284811:AGOS_AFL139W ^@ http://purl.uniprot.org/uniprot/Q755G2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/284811:AGOS_ADR290W ^@ http://purl.uniprot.org/uniprot/Q759I7 ^@ Cofactor|||Similarity ^@ Belongs to the glutamate synthase family.|||Binds 1 [3Fe-4S] cluster. http://togogenome.org/gene/284811:AGOS_AER326C ^@ http://purl.uniprot.org/uniprot/Q756E1 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus|||Ubiquitination of histone H2B to form H2BK123ub1 is required for efficient DOT1 methyltransferase activity on histone H3. http://togogenome.org/gene/284811:AGOS_AFR597W ^@ http://purl.uniprot.org/uniprot/Q752H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 85 family.|||cytosol http://togogenome.org/gene/284811:AGOS_ACL125C ^@ http://purl.uniprot.org/uniprot/Q75CP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/284811:AGOS_AFR579W ^@ http://purl.uniprot.org/uniprot/Q752J5 ^@ Miscellaneous|||Similarity ^@ Belongs to the universal ribosomal protein uS8 family.|||There are two genes for S22 in A.gossypii. http://togogenome.org/gene/284811:AGOS_AGR331C ^@ http://purl.uniprot.org/uniprot/Q74Z75 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus|||This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).|||telomere http://togogenome.org/gene/284811:AGOS_AFL113C ^@ http://purl.uniprot.org/uniprot/Q755D6 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AAL044C ^@ http://purl.uniprot.org/uniprot/Q75EX2 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/284811:AGOS_AER275C ^@ http://purl.uniprot.org/uniprot/Q756I6 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/284811:AGOS_ABR006W ^@ http://purl.uniprot.org/uniprot/Q75DS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL004W ^@ http://purl.uniprot.org/uniprot/Q757L5 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/284811:AGOS_AFR743W ^@ http://purl.uniprot.org/uniprot/Q751T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic10 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR004W ^@ http://purl.uniprot.org/uniprot/Q750F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AFL017W ^@ http://purl.uniprot.org/uniprot/Q754T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC5 family.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR066W ^@ http://purl.uniprot.org/uniprot/Q74ZZ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Homodimer.|||In the 2nd section; belongs to the EPSP synthase family.|||In the 3rd section; belongs to the shikimate kinase family.|||In the 4th section; belongs to the type-I 3-dehydroquinase family.|||In the C-terminal section; belongs to the shikimate dehydrogenase family.|||In the N-terminal section; belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||The AROM polypeptide catalyzes 5 consecutive enzymatic reactions in prechorismate polyaromatic amino acid biosynthesis. http://togogenome.org/gene/284811:AGOS_ADL057W ^@ http://purl.uniprot.org/uniprot/Q75AI4 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/284811:AGOS_AGR370W ^@ http://purl.uniprot.org/uniprot/Q74Z36 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_ADR206W ^@ http://purl.uniprot.org/uniprot/Q759R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL3 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR327C ^@ http://purl.uniprot.org/uniprot/Q753I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR321C ^@ http://purl.uniprot.org/uniprot/Q753J1 ^@ Function|||Subcellular Location Annotation ^@ Involved in the mitochondrial expression of subunits 6 and 8 of the F0-F1 ATP synthase.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ACR197W ^@ http://purl.uniprot.org/uniprot/Q75BS4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping by activating the decapping enzyme DCP1. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).|||Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.|||P-body|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AGL255W ^@ http://purl.uniprot.org/uniprot/Q751G1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SGF11 family.|||Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with SGF73, SUS1 and UBP8.|||Functions as component of the transcription regulatory histone acetylation (HAT) complex SAGA. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. SAGA acetylates nucleosomal histone H3 to some extent (to form H3K9ac, H3K14ac, H3K18ac and H3K23ac). SAGA interacts with DNA via upstream activating sequences (UASs). Involved in transcriptional regulation of a subset of SAGA-regulated genes. Within the SAGA complex, participates in a subcomplex, that specifically deubiquitinates histones H2B.|||Nucleus|||The C-terminal SGF11-type zinc-finger domain together with the C-terminal catalytic domain of UBP8 forms the 'catalytic lobe' of the SAGA deubiquitination module.|||The long N-terminal helix forms part of the 'assembly lobe' of the SAGA deubiquitination module. http://togogenome.org/gene/284811:AGOS_ADR048W ^@ http://purl.uniprot.org/uniprot/Q75A70 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/284811:AGOS_AGL316W ^@ http://purl.uniprot.org/uniprot/Q751S0 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/284811:AGOS_AER215W ^@ http://purl.uniprot.org/uniprot/Q756N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER030C ^@ http://purl.uniprot.org/uniprot/Q757I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR012C ^@ http://purl.uniprot.org/uniprot/Q754R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR114W ^@ http://purl.uniprot.org/uniprot/Q754F6 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/284811:AGOS_ADR148W ^@ http://purl.uniprot.org/uniprot/Q759X5 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/284811:AGOS_AGR342C ^@ http://purl.uniprot.org/uniprot/P62511 ^@ Function|||Similarity ^@ Belongs to the uridine kinase family. NRK subfamily.|||Catalyzes the phosphorylation of nicotinamide riboside (NR) and nicotinic acid riboside (NaR) to form nicotinamide mononucleotide (NMN) and nicotinic acid mononucleotide (NaMN). http://togogenome.org/gene/284811:AGOS_AFL109W ^@ http://purl.uniprot.org/uniprot/Q755D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the U2 small nuclear ribonucleoprotein A family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR009W ^@ http://purl.uniprot.org/uniprot/Q75CA3 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/284811:AGOS_AAR185W ^@ http://purl.uniprot.org/uniprot/Q75E95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DAD1 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_ABR156W ^@ http://purl.uniprot.org/uniprot/Q75D67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR469W ^@ http://purl.uniprot.org/uniprot/Q752V4 ^@ Similarity ^@ Belongs to the SNAP-25 family. http://togogenome.org/gene/284811:AGOS_ABR113C ^@ http://purl.uniprot.org/uniprot/Q75DB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL144C ^@ http://purl.uniprot.org/uniprot/Q75AR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC25 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR264W ^@ http://purl.uniprot.org/uniprot/Q753P8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily. http://togogenome.org/gene/284811:AGOS_ACR253C ^@ http://purl.uniprot.org/uniprot/Q75BL8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).|||Cytoplasm|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AGR221W ^@ http://purl.uniprot.org/uniprot/Q74ZI1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/284811:AGOS_AGL352W ^@ http://purl.uniprot.org/uniprot/Q751P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_ADR163W ^@ http://purl.uniprot.org/uniprot/Q759V9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AAL098W ^@ http://purl.uniprot.org/uniprot/Q75F26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG29 family.|||Plays a role in autophagy. Functions at the preautophagosomal structure (PAS) in order to form normal autophagosomes under starvation conditions. Also plays a role in mitophagy and regulation of filamentous growth (By similarity).|||Preautophagosomal structure http://togogenome.org/gene/284811:AGOS_AEL316W ^@ http://purl.uniprot.org/uniprot/Q758R9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR052C ^@ http://purl.uniprot.org/uniprot/Q750A5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3' to 5' exoribonuclease required for proper 3' end maturation of MRP RNA and of the U5L snRNA.|||Belongs to the REXO1/REXO3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL158C ^@ http://purl.uniprot.org/uniprot/Q75AS8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/284811:AGOS_AER118C ^@ http://purl.uniprot.org/uniprot/Q756Z5 ^@ Similarity|||Subunit ^@ Belongs to the PPP phosphatase family. PP-2B subfamily.|||Composed of two components (A and B), the A component is the catalytic subunit and the B component confers calcium sensitivity. http://togogenome.org/gene/284811:AGOS_AGR206C ^@ http://purl.uniprot.org/uniprot/Q74ZW3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/284811:AGOS_ACL078W ^@ http://purl.uniprot.org/uniprot/Q75CJ7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/284811:AGOS_ABL102C ^@ http://purl.uniprot.org/uniprot/Q75DX5 ^@ Similarity ^@ Belongs to the class-I DAHP synthase family. http://togogenome.org/gene/284811:AGOS_ADR193W ^@ http://purl.uniprot.org/uniprot/Q759T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play a role in changing or maintaining the spatial distribution of cytoskeletal structures (By similarity). Also a component of the nuclear pore complex (By similarity).|||Belongs to the dynein light chain family.|||Homodimer. Cytoplasmic dynein consists of two catalytic heavy chains (HCs) and a number of non-catalytic subunits which present intermediate chains (ICs), light intermediate chains (LICs) and light chains (LCs). Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.|||cytoskeleton|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AFR184C ^@ http://purl.uniprot.org/uniprot/Q753Y8 ^@ Function|||Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family.|||Catalyzes the cleavage of glutathione into 5-oxo-L-proline and a Cys-Gly dipeptide. Acts specifically on glutathione, but not on other gamma-glutamyl peptides. http://togogenome.org/gene/284811:AGOS_ACR031W ^@ http://purl.uniprot.org/uniprot/Q75C85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR018C ^@ http://purl.uniprot.org/uniprot/Q754Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family.|||Functions as a sorting receptor in the Golgi compartment required for the intracellular sorting and delivery of soluble vacuolar proteins, like carboxypeptidase Y (CPY) and proteinase A. Executes multiple rounds of sorting by cycling between the late Golgi and a prevacuolar endosome-like compartment (By similarity).|||Prevacuolar compartment membrane|||trans-Golgi network membrane http://togogenome.org/gene/284811:AGOS_AAR184W ^@ http://purl.uniprot.org/uniprot/Q75E96 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/284811:AGOS_AER128W ^@ http://purl.uniprot.org/uniprot/Q756Y6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the helicase family. PIF1 subfamily.|||DNA-dependent ATPase and 5'-3' DNA helicase required for the maintenance of both mitochondrial and nuclear genome stability. Efficiently unwinds G-quadruplex (G4) DNA structures and forked RNA-DNA hybrids. Resolves G4 structures, preventing replication pausing and double-strand breaks (DSBs) at G4 motifs. Involved in the maintenance of telomeric DNA. Inhibits telomere elongation, de novo telomere formation and telomere addition to DSBs via catalytic inhibition of telomerase. Reduces the processivity of telomerase by displacing active telomerase from DNA ends. Releases telomerase by unwinding the short telomerase RNA/telomeric DNA hybrid that is the intermediate in the telomerase reaction. Involved in the maintenance of ribosomal (rDNA). Required for efficient fork arrest at the replicaion fork barrier within rDNA. Involved in the maintenance of mitochondrial (mtDNA). Required to maintain mtDNA under conditions that introduce dsDNA breaks in mtDNA, either preventing or repairing dsDNA breaks. May inhibit replication progression to allow time for repair. May have a general role in chromosomal replication by affecting Okazaki fragment maturation. May have a role in conjunction with DNA2 helicase/nuclease in 5'-flap extension during Okazaki fragment processing.|||Mitochondrion|||Monomer. Interacts with telomerase.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL044C ^@ http://purl.uniprot.org/uniprot/Q75DR1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_ADL229W ^@ http://purl.uniprot.org/uniprot/Q75AZ9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR017W ^@ http://purl.uniprot.org/uniprot/Q75C99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail.|||Cytoplasm|||Nucleus|||Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. http://togogenome.org/gene/284811:AGOS_ACL077C ^@ http://purl.uniprot.org/uniprot/Q75CJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribose 5-phosphate isomerase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR725C ^@ http://purl.uniprot.org/uniprot/Q751V0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||GTPase-activating protein for the ADP ribosylation factor family. http://togogenome.org/gene/284811:AGOS_ACL039W ^@ http://purl.uniprot.org/uniprot/Q75CF8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_ABL020W ^@ http://purl.uniprot.org/uniprot/Q75DN7 ^@ Similarity ^@ Belongs to the MUB1/samB family. http://togogenome.org/gene/284811:AGOS_AEL225C ^@ http://purl.uniprot.org/uniprot/Q758I7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SETD6 subfamily.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that monomethylates 60S ribosomal protein L42. http://togogenome.org/gene/284811:AGOS_AGR300W ^@ http://purl.uniprot.org/uniprot/Q74ZA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||cis-Golgi network http://togogenome.org/gene/284811:AGOS_ADR210C ^@ http://purl.uniprot.org/uniprot/Q759R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the second glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(1)Man(9)GlcNAc(2)-PP-Dol (By similarity).|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AER307W ^@ http://purl.uniprot.org/uniprot/Q756F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDC1 family.|||Membrane|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AEL169W ^@ http://purl.uniprot.org/uniprot/Q758C1 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/284811:AGOS_AEL182W ^@ http://purl.uniprot.org/uniprot/Q758E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome subunit S5B/HSM3 family.|||Cytoplasm|||Involved in DNA mismatch repair in slow-growing cells. Acts as a chaperone during the assembly of the 26S proteasome, specifically of the base subcomplex of the 19S regulatory complex (RC) (By similarity). http://togogenome.org/gene/284811:AGOS_AFL107W ^@ http://purl.uniprot.org/uniprot/Q755D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic GTase family.|||Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.|||Nucleus|||Second step of mRNA capping. Transfer of the GMP moiety of GTP to the 5'-end of RNA via an enzyme-GMP covalent reaction intermediate. http://togogenome.org/gene/284811:AGOS_AAL082W ^@ http://purl.uniprot.org/uniprot/Q75F10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 20 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR289W ^@ http://purl.uniprot.org/uniprot/Q753M3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTAG/PCC1 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. PCC1 functions as a dimerization module for the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators (By similarity).|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ABL030W ^@ http://purl.uniprot.org/uniprot/Q75DP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AFR599W ^@ http://purl.uniprot.org/uniprot/Q752H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transferase hexapeptide repeat family.|||Cytoplasm|||Involved in cell wall synthesis where it is required for glycosylation. Involved in cell cycle progression through cell-size checkpoint (By similarity). http://togogenome.org/gene/284811:AGOS_AER147W ^@ http://purl.uniprot.org/uniprot/Q756V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG8 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL256W ^@ http://purl.uniprot.org/uniprot/Q751G2 ^@ Function|||Similarity ^@ Belongs to the catalase family.|||Occurs in almost all aerobically respiring organisms and serves to protect cells from the toxic effects of hydrogen peroxide. http://togogenome.org/gene/284811:AGOS_ABL153W ^@ http://purl.uniprot.org/uniprot/Q75E23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER340W ^@ http://purl.uniprot.org/uniprot/Q756C7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the misato family.|||Involved in the partitioning of the mitochondrial organelle and mitochondrial DNA (mtDNA) inheritance.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ACR271C ^@ http://purl.uniprot.org/uniprot/Q75BK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTU2/NCS2 family.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). May act by forming a heterodimer with NCS6 that ligates sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/284811:AGOS_AFL158C ^@ http://purl.uniprot.org/uniprot/Q755I1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR271W ^@ http://purl.uniprot.org/uniprot/Q759K6 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/284811:AGOS_AFL057W ^@ http://purl.uniprot.org/uniprot/Q754X3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/284811:AGOS_AER091W ^@ http://purl.uniprot.org/uniprot/Q757C2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGR088W ^@ http://purl.uniprot.org/uniprot/Q74ZX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSF1 family.|||Membrane|||Required for the glucose and other nutrients uptake at low temperature. http://togogenome.org/gene/284811:AGOS_AGL126C ^@ http://purl.uniprot.org/uniprot/Q751A6 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/284811:AGOS_ADL009W ^@ http://purl.uniprot.org/uniprot/Q75AC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFL079W ^@ http://purl.uniprot.org/uniprot/Q755A4 ^@ Function ^@ Delta(8)-fatty-acid desaturase which introduces a double bond at the 8-position in the long-chain base (LCB) of ceramides. Required for the formation of the di-unsaturated sphingoid base (E,E)-sphinga-4,8-dienine during glucosylceramide (GluCer) biosynthesis. http://togogenome.org/gene/284811:AGOS_ACL065C ^@ http://purl.uniprot.org/uniprot/Q75CI4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Component of complex II composed of four subunits: a flavoprotein (FP), an iron-sulfur protein (IP), and a cytochrome b composed of a large and a small subunit.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR329C ^@ http://purl.uniprot.org/uniprot/Q753I3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DGK1 family.|||CTP-dependent diacylglycerol kinase that catalyzes the phosphorylation of diacylglycerol (DAG) to phosphatidate (PA). Controls phosphatidate levels at the nuclear envelope. May be involved in vesicle trafficking between the endoplasmic reticulum and the Golgi apparatus.|||Endoplasmic reticulum membrane|||Nucleus membrane http://togogenome.org/gene/284811:AGOS_AFR287W ^@ http://purl.uniprot.org/uniprot/Q753M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL131W ^@ http://purl.uniprot.org/uniprot/Q750S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR284C ^@ http://purl.uniprot.org/uniprot/Q75BI7 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/284811:AGOS_ABR161C ^@ http://purl.uniprot.org/uniprot/Q75D62 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/284811:AGOS_AFR254C ^@ http://purl.uniprot.org/uniprot/Q753S2 ^@ Function|||Similarity ^@ Catalyzes the second and fifth step in the 'de novo' purine biosynthesis pathway; contains phosphoribosylamine--glycine ligase (GARS) and phosphoribosylformylglycinamidine cyclo-ligase (AIRS) activities.|||In the C-terminal section; belongs to the AIR synthase family.|||In the N-terminal section; belongs to the GARS family. http://togogenome.org/gene/284811:AGOS_AFR343C ^@ http://purl.uniprot.org/uniprot/Q753G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR196C ^@ http://purl.uniprot.org/uniprot/Q75D26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Part of a complex that contains SEC61, SEC62, SEC63, SEC66 and SEC72.|||Required for preprotein translocation. http://togogenome.org/gene/284811:AGOS_AGR002W ^@ http://purl.uniprot.org/uniprot/Q750F3 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/284811:AGOS_ACR145W ^@ http://purl.uniprot.org/uniprot/Q8J1G1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Required for assembly of the mitotic spindle.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_ACR142W ^@ http://purl.uniprot.org/uniprot/Q75CE9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily.|||Controls S-phase checkpoint as well as G1 and G2 DNA damage checkpoints. Phosphorylates proteins on serine, threonine, and tyrosine. Prevents entry into anaphase and mitotic exit after DNA damage via regulation of the Polo kinase CDC5.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR102C ^@ http://purl.uniprot.org/uniprot/Q74ZU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family.|||Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.|||Cytoplasm|||Nucleus|||Probable metalloprotease involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity). http://togogenome.org/gene/284811:AGOS_AEL307C ^@ http://purl.uniprot.org/uniprot/Q758R0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHE2 family.|||Cytoplasm|||Homodimer and homotetramer.|||Nucleus|||RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell (By similarity). http://togogenome.org/gene/284811:AGOS_AFR545W ^@ http://purl.uniprot.org/uniprot/Q752M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKN1/KRE6 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER143W ^@ http://purl.uniprot.org/uniprot/Q756V8 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/284811:AGOS_AAR131W ^@ http://purl.uniprot.org/uniprot/Q75EF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the crooked-neck family.|||Involved in pre-mRNA splicing and cell cycle progression.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR216C ^@ http://purl.uniprot.org/uniprot/Q75BQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR071C ^@ http://purl.uniprot.org/uniprot/Q74ZY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC45 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL184C ^@ http://purl.uniprot.org/uniprot/Q75CV0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/284811:AGOS_ADR239W ^@ http://purl.uniprot.org/uniprot/Q759N6 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/284811:AGOS_AGL287W ^@ http://purl.uniprot.org/uniprot/Q751J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with DNA double-strand breaks.|||Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, involved in the regulation of DNA damage response mechanism. Required for the control of telomere length and genome stability (By similarity).|||telomere http://togogenome.org/gene/284811:AGOS_AFL037W ^@ http://purl.uniprot.org/uniprot/Q754Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGL039W ^@ http://purl.uniprot.org/uniprot/Q750J0 ^@ Function|||Similarity ^@ Belongs to the NPR3 family.|||Mediates inactivation of the TORC1 complex in response to amino acid starvation. Required for meiotic nuclear division (By similarity). http://togogenome.org/gene/284811:AGOS_ACR084C ^@ http://purl.uniprot.org/uniprot/Q75C33 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/284811:AGOS_AFR720W ^@ http://purl.uniprot.org/uniprot/Q751V5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC1 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADR083W ^@ http://purl.uniprot.org/uniprot/Q75A36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). http://togogenome.org/gene/284811:AGOS_AGL200W ^@ http://purl.uniprot.org/uniprot/Q751B0 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AER206C ^@ http://purl.uniprot.org/uniprot/Q756P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/284811:AGOS_AEL195W ^@ http://purl.uniprot.org/uniprot/Q758F7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AFR218W ^@ http://purl.uniprot.org/uniprot/Q754H6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NCBP1 family.|||Component of the cap-binding complex (CBC) involved in the nuclear export of capped U snRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation; and involved in rRNA processing at sites A0, A1 and A2 (By similarity).|||Component of the nuclear cap-binding complex (CBC).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL112W ^@ http://purl.uniprot.org/uniprot/Q755D5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL235W ^@ http://purl.uniprot.org/uniprot/Q75B12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Endoplasmic reticulum membrane|||Required for N-linked oligosaccharide assembly. Has a role in the last step of the synthesis of the Man(5)GlcNAc(2)-PP-dolichol core oligosaccharide on the cytoplasmic face of the endoplasmic reticulum (By similarity). http://togogenome.org/gene/284811:AGOS_ACR218W ^@ http://purl.uniprot.org/uniprot/Q75BQ3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284811:AGOS_ADL384W ^@ http://purl.uniprot.org/uniprot/Q75BE8 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284811:AGOS_ACR088W ^@ http://purl.uniprot.org/uniprot/Q75C29 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/284811:AGOS_ACR188C ^@ http://purl.uniprot.org/uniprot/Q75BT3 ^@ Similarity ^@ Belongs to the indoleamine 2,3-dioxygenase family. http://togogenome.org/gene/284811:AGOS_ADR120C ^@ http://purl.uniprot.org/uniprot/Q75A07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family.|||Mitochondrion|||N-acetylglutamate synthase involved in arginine biosynthesis. http://togogenome.org/gene/284811:AGOS_AGR344W ^@ http://purl.uniprot.org/uniprot/Q74Z62 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/284811:AGOS_ABR119C ^@ http://purl.uniprot.org/uniprot/Q75DA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR552C ^@ http://purl.uniprot.org/uniprot/Q752M2 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/284811:AGOS_ABL066C ^@ http://purl.uniprot.org/uniprot/Q75DT9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM31/MDM32 family.|||Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL203C ^@ http://purl.uniprot.org/uniprot/Q750Z0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_AFR249W ^@ http://purl.uniprot.org/uniprot/Q753S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AER268W ^@ http://purl.uniprot.org/uniprot/Q756W6 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. http://togogenome.org/gene/284811:AGOS_AFR099C ^@ http://purl.uniprot.org/uniprot/Q754H3 ^@ Similarity ^@ Belongs to the TRL1 family. http://togogenome.org/gene/284811:AGOS_AGL211C ^@ http://purl.uniprot.org/uniprot/Q751B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ABL159W ^@ http://purl.uniprot.org/uniprot/Q75E29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_AFR004W ^@ http://purl.uniprot.org/uniprot/Q754R8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus|||Part of the chromatin structure-remodeling complex (RSC) which is involved in transcription regulation and nucleosome positioning. RSC is responsible for the transfer of a histone octamer from a nucleosome core particle to naked DNA. The reaction requires ATP and involves an activated RSC-nucleosome intermediate. Remodeling reaction also involves DNA translocation, DNA twist and conformational change. As a reconfigurer of centromeric and flanking nucleosomes, RSC complex is required both for proper kinetochore function in chromosome segregation and, via a PKC1-dependent signaling pathway, for organization of the cellular cytoskeleton. This subunit is essential for mitotic growth and required for cell cycle progression (By similarity). http://togogenome.org/gene/284811:AGOS_AFR692C ^@ http://purl.uniprot.org/uniprot/Q751Y3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/284811:AGOS_AGR083W ^@ http://purl.uniprot.org/uniprot/Q74ZX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR139W ^@ http://purl.uniprot.org/uniprot/Q75EE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOB1 family.|||Required for the synthesis of 40S ribosome subunits. Has a role in processing 20S pre-rRNA into the mature 18S rRNA, where it is required for cleavage at the 3' end of the mature 18S rRNA (D-site). Accompanies the 20S pre-rRNA from the nucleus to the cytoplasm.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABR164W ^@ http://purl.uniprot.org/uniprot/Q75D59 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/284811:AGOS_ABR129C ^@ http://purl.uniprot.org/uniprot/Q75D95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL340W ^@ http://purl.uniprot.org/uniprot/Q758U2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SIL1 family.|||Endoplasmic reticulum lumen|||Interacts with KAR2.|||Required for protein translocation and folding in the endoplasmic reticulum (ER). Functions as a nucleotide exchange factor for the ER lumenal chaperone KAR2 (By similarity). http://togogenome.org/gene/284811:AGOS_ABL065W ^@ http://purl.uniprot.org/uniprot/Q75DT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/284811:AGOS_ABR212C ^@ http://purl.uniprot.org/uniprot/Q75D10 ^@ Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/284811:AGOS_AFR561W ^@ http://purl.uniprot.org/uniprot/Q752L3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AGL054W ^@ http://purl.uniprot.org/uniprot/Q750K5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/284811:AGOS_ADR320C ^@ http://purl.uniprot.org/uniprot/Q759F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ASF1 family.|||Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.|||Interacts with histone H3 and histone H4.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL123W ^@ http://purl.uniprot.org/uniprot/Q757Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR196W ^@ http://purl.uniprot.org/uniprot/Q74ZK4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Maintains high levels of reduced glutathione in the cytosol.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/284811:AGOS_AFL038C ^@ http://purl.uniprot.org/uniprot/Q754Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Membrane|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AEL132W ^@ http://purl.uniprot.org/uniprot/Q757Z2 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/284811:AGOS_AGR264C ^@ http://purl.uniprot.org/uniprot/Q74ZD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.|||Cooperates with the reticulon proteins and tubule-shaping DP1 family proteins to generate and maintain the structure of the tubular endoplasmic reticulum network. Has GTPase activity, which is required for its function in ER organization.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AGL002C ^@ http://purl.uniprot.org/uniprot/Q750F6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SNF8 family.|||Component of the endosomal sorting complex required for transport II (ESCRT-II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II). http://togogenome.org/gene/284811:AGOS_AGL022W ^@ http://purl.uniprot.org/uniprot/Q750L4 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/284811:AGOS_AFL025C ^@ http://purl.uniprot.org/uniprot/Q754U6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR622W ^@ http://purl.uniprot.org/uniprot/Q752F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR003C ^@ http://purl.uniprot.org/uniprot/Q754R9 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/284811:AGOS_AER441C ^@ http://purl.uniprot.org/uniprot/Q755S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_ADL163W ^@ http://purl.uniprot.org/uniprot/Q75AT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase TRM13 family.|||Cytoplasm|||nucleolus|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/284811:AGOS_ADL341C ^@ http://purl.uniprot.org/uniprot/Q75BA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER293C ^@ http://purl.uniprot.org/uniprot/Q756H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR138C ^@ http://purl.uniprot.org/uniprot/Q759Y5 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of acetylglutamate from glutamate and acetyl-CoA, and of ornithine by transacetylation between acetylornithine and glutamate.|||Heterodimer of an alpha and a beta chain.|||Mitochondrion matrix|||The alpha and beta chains are autoproteolytically processed from a single precursor protein within the mitochondrion.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/284811:AGOS_ABR079C ^@ http://purl.uniprot.org/uniprot/Q75DE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex ASK1 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_ACL132C ^@ http://purl.uniprot.org/uniprot/Q75CQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLASP family.|||Belongs to the TOG/XMAP215 family.|||spindle http://togogenome.org/gene/284811:AGOS_ADR226C ^@ http://purl.uniprot.org/uniprot/Q759P7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP38/TMEM64 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking and spindle migration.|||The VTT domain was previously called the SNARE-assoc domain. As there is no evidence that this domain associates with SNARE proteins, it was renamed as VMP1, TMEM41, and TVP38 (VTT) domain. http://togogenome.org/gene/284811:AGOS_AGR149W ^@ http://purl.uniprot.org/uniprot/Q74ZP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Required for vacuolar assembly and vacuolar traffic.|||Vacuole http://togogenome.org/gene/284811:AGOS_ACR220C ^@ http://purl.uniprot.org/uniprot/Q75BQ1 ^@ Similarity ^@ Belongs to the TMCO4 family. http://togogenome.org/gene/284811:AGOS_ADL102C ^@ http://purl.uniprot.org/uniprot/Q75AM5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ADL126C ^@ http://purl.uniprot.org/uniprot/Q75AP6 ^@ Function|||Similarity ^@ Belongs to the RRT5 family.|||May be involved in the modulation of rDNA transcription. http://togogenome.org/gene/284811:AGOS_AFL078W ^@ http://purl.uniprot.org/uniprot/Q755A3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OXR1 family.|||May be involved in protection from oxidative damage.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ACR008W ^@ http://purl.uniprot.org/uniprot/Q75CA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Involved in ds DNA break repair. Has a role in non-homologous integration (NHI) pathways where it is required in the final step of non-homologous end-joining.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR241C ^@ http://purl.uniprot.org/uniprot/Q75BN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OAF3 family.|||Cytoplasm|||Mitochondrion|||Nucleus|||Transcriptional inhibitor with a significantly increased number of target genes in response to oleate. http://togogenome.org/gene/284811:AGOS_ADL378W ^@ http://purl.uniprot.org/uniprot/Q75BE2 ^@ Similarity ^@ Belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/284811:AGOS_ADL372W ^@ http://purl.uniprot.org/uniprot/Q75BH5 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/284811:AGOS_ABL192C ^@ http://purl.uniprot.org/uniprot/Q75E62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SQS1 family.|||Cytoplasm|||May be involved in splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR073W ^@ http://purl.uniprot.org/uniprot/Q75A46 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/284811:AGOS_AFR071W ^@ http://purl.uniprot.org/uniprot/Q754K1 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/284811:AGOS_ABR047W ^@ http://purl.uniprot.org/uniprot/Q75DH8 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/284811:AGOS_ADL393W ^@ http://purl.uniprot.org/uniprot/Q755R3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABL150W ^@ http://purl.uniprot.org/uniprot/Q75E20 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/284811:AGOS_AAR046C ^@ http://purl.uniprot.org/uniprot/Q75EN3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Binds to both phosphatidylinositol (PI) and phosphatidylinositol 3,5-bisphosphate (PIP2).|||Lipase which is essential for lysis of subvacuolar cytoplasm to vacuole targeted bodies and intravacuolar autophagic bodies. Involved in the lysis of intravacuolar multivesicular body (MVB) vesicles. The intravacuolar membrane disintegration by ATG15 is critical to life span extension (By similarity).|||Prevacuolar compartment membrane|||multivesicular body membrane http://togogenome.org/gene/284811:AGOS_AGL343C ^@ http://purl.uniprot.org/uniprot/Q751R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/284811:AGOS_AFR086C ^@ http://purl.uniprot.org/uniprot/Q754I8 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/284811:AGOS_ADL296C ^@ http://purl.uniprot.org/uniprot/Q75B68 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase II family. http://togogenome.org/gene/284811:AGOS_AGR038C ^@ http://purl.uniprot.org/uniprot/Q750B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL002W ^@ http://purl.uniprot.org/uniprot/Q8J1F8 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of N-terminal lysines and particularly formation of H2BK11ac has a positive effect on transcription.|||Belongs to the histone H2B family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).|||Nucleus|||Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).|||Sumoylation to form H2BK6su or H2BK7su occurs preferentially near the telomeres and represses gene transcription.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BK7ac = acetylated Lys-8; H2BK7su = sumoylated Lys-8; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK123ub1 = monoubiquitinated Lys-120. http://togogenome.org/gene/284811:AGOS_AGL350C ^@ http://purl.uniprot.org/uniprot/Q751P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PINX1 family.|||Involved in rRNA-processing at A0, A1 and A2 sites and regulates negatively telomerase.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR571W ^@ http://purl.uniprot.org/uniprot/Q752K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_ADL307W ^@ http://purl.uniprot.org/uniprot/Q75B79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG11 family.|||Homodimer.|||Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Recruits mitochondria for their selective degradation via autophagy (mitophagy) during starvation. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation. Required for the Cvt vesicles completion (By similarity).|||Preautophagosomal structure membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFR020W ^@ http://purl.uniprot.org/uniprot/Q754Q2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyl-CoA hydrolase/transferase family.|||Cytoplasm|||Presumably involved in regulating the intracellular acetyl-CoA pool for fatty acid and cholesterol synthesis and fatty acid oxidation. http://togogenome.org/gene/284811:AGOS_ADR419C ^@ http://purl.uniprot.org/uniprot/Q758V9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR306W ^@ http://purl.uniprot.org/uniprot/Q759I2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPI1/TEX10 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL134W ^@ http://purl.uniprot.org/uniprot/Q755F7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fungal TPase family.|||First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.|||Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL049C ^@ http://purl.uniprot.org/uniprot/Q75EX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 21 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER048C ^@ http://purl.uniprot.org/uniprot/Q757G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC7 family.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER046W ^@ http://purl.uniprot.org/uniprot/Q757G7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAD52 family.|||Interacts with RAD51 and RAD52.|||Involved in the repair of double-strand breaks in DNA during vegetative growth via recombination and single-strand annealing. Anneals complementary single-stranded DNA (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR003C ^@ http://purl.uniprot.org/uniprot/Q75AB5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/284811:AGOS_ABL138W ^@ http://purl.uniprot.org/uniprot/Q75E11 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/284811:AGOS_AGL100W ^@ http://purl.uniprot.org/uniprot/Q751B2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EST1 family.|||Involved in telomere maintenance.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AEL207W ^@ http://purl.uniprot.org/uniprot/Q9HFW3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Catalytic subunit of the TRAMP5 complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates like cryptic transcripts generated by RNA polymerase II and III, or hypomethylated pre-tRNAi-Met. Polyadenylates RNA processing and degradation intermediates of snRNAs, snoRNAs and mRNAs that accumulate in strains lacking a functional exosome. TRF5 is also required for proper nuclear division in mitosis and sister chromatid cohesion. Involved in the regulation of histone mRNA levels. May mediate mitotic chromosome condensation (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL047W ^@ http://purl.uniprot.org/uniprot/Q75CG6 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/284811:AGOS_ABL085W ^@ http://purl.uniprot.org/uniprot/Q75DV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/284811:AGOS_AAR077C ^@ http://purl.uniprot.org/uniprot/Q75EK2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/284811:AGOS_ABL021C ^@ http://purl.uniprot.org/uniprot/Q75DN8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ABR188W ^@ http://purl.uniprot.org/uniprot/Q75D35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR053C ^@ http://purl.uniprot.org/uniprot/Q754L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR211W ^@ http://purl.uniprot.org/uniprot/Q74ZJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NPL4 family.|||Endoplasmic reticulum membrane|||Involved in the import of nuclear-targeted proteins into the nucleus and the export of poly(A) RNA out of the nucleus. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway (By similarity).|||Nucleus membrane|||perinuclear region http://togogenome.org/gene/284811:AGOS_ABR091C ^@ http://purl.uniprot.org/uniprot/Q75DD6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCS1 family.|||Binds 2 copper ions per subunit.|||Copper chaperone for superoxide dismutase 1 (SOD1). Binds copper ions and delivers them specifically to SOD1 (By similarity).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL167C ^@ http://purl.uniprot.org/uniprot/Q758B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AAR161W ^@ http://purl.uniprot.org/uniprot/Q75ED7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DUO1 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AGL221W ^@ http://purl.uniprot.org/uniprot/Q751C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC2 family.|||Component of the Arp2/3 complex.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AER056C ^@ http://purl.uniprot.org/uniprot/Q757F7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_AER298C ^@ http://purl.uniprot.org/uniprot/Q756G8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG7 family.|||Cytoplasm|||E1-like activating enzyme involved in the 2 ubiquitin-like systems required for cytoplasm to vacuole transport (Cvt) and autophagy. Activates ATG12 for its conjugation with ATG5 and ATG8 for its conjugation with phosphatidylethanolamine. Both systems are needed for the ATG8 association to Cvt vesicles and autophagosomes membranes. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Plays a role in the regulation of filamentous growth and chronological longevity (By similarity).|||Homodimer.|||Preautophagosomal structure|||The GxGxxG motif is important for the function, possibly through binding with ATP. http://togogenome.org/gene/284811:AGOS_AGR015C ^@ http://purl.uniprot.org/uniprot/Q750E0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Binds 1 zinc ion per monomer.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity).|||Homooctamer. http://togogenome.org/gene/284811:AGOS_ACL196W ^@ http://purl.uniprot.org/uniprot/Q75CW2 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/284811:AGOS_ABL112W ^@ http://purl.uniprot.org/uniprot/Q75DY5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284811:AGOS_ADR275W ^@ http://purl.uniprot.org/uniprot/Q759K2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a farnesyl moiety from farnesyl diphosphate to a cysteine at the fourth position from the C-terminus of several proteins. The beta subunit is responsible for peptide-binding.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/284811:AGOS_ADR230W ^@ http://purl.uniprot.org/uniprot/Q75A03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DIA2 family.|||F-box protein component of a SCF ubiquitin ligase complex involved in ubiquitin-dependent protein degradation. The SCF-DIA2 complex is specifically involved in the pheromone induced degradation of phosphorylated TEC1. Involved in DNA replication, genome stability, and the control of cell cycle, probably through its association to replication origins to facilitate the ubiquitination of another origin-binding protein (By similarity).|||Forms a SCF ubiquitin ligase complex which binds to DNA replication origins.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL014C ^@ http://purl.uniprot.org/uniprot/Q757M2 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/284811:AGOS_AGL052W ^@ http://purl.uniprot.org/uniprot/Q750K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGL281C ^@ http://purl.uniprot.org/uniprot/Q751I7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/284811:AGOS_ADL017C ^@ http://purl.uniprot.org/uniprot/Q75AD4 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/284811:AGOS_ADR096C ^@ http://purl.uniprot.org/uniprot/Q75A24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR337W ^@ http://purl.uniprot.org/uniprot/Q753H5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.|||Belongs to the ADIPOR family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AFR639W ^@ http://purl.uniprot.org/uniprot/Q752D7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DPH4 family.|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, the transfer of 3-amino-3-carboxypropyl from S-adenosyl-L-methionine to a histidine residue. Diphthamide is a post-translational modification of histidine which occurs in elongation factor 2 (By similarity).|||The DPH-type metal-binding (MB) domain can bind either zinc or iron ions. http://togogenome.org/gene/284811:AGOS_AAL157C ^@ http://purl.uniprot.org/uniprot/Q75F99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL100W ^@ http://purl.uniprot.org/uniprot/Q75AM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG28 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR562C ^@ http://purl.uniprot.org/uniprot/Q752L2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR065C ^@ http://purl.uniprot.org/uniprot/Q75C52 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_AER229C ^@ http://purl.uniprot.org/uniprot/Q756M5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M49 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_ACR011C ^@ http://purl.uniprot.org/uniprot/Q75CA1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AFR370C ^@ http://purl.uniprot.org/uniprot/Q753E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||Component of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||coated pit http://togogenome.org/gene/284811:AGOS_ABR080W ^@ http://purl.uniprot.org/uniprot/Q75DE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR096C ^@ http://purl.uniprot.org/uniprot/Q75DD1 ^@ Function|||Similarity ^@ Belongs to the NDK family.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). http://togogenome.org/gene/284811:AGOS_AFL156W ^@ http://purl.uniprot.org/uniprot/Q755H9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/284811:AGOS_ABR183W ^@ http://purl.uniprot.org/uniprot/Q9HF54 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family.|||Cell membrane|||Involved in the regulation of actin polarization. Rho proteins are required for distinct steps during polarized hyphal growth of A.gossypii. http://togogenome.org/gene/284811:AGOS_ACR032C ^@ http://purl.uniprot.org/uniprot/Q75C84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||Required for synthesis of 60S ribosomal subunits and the transport of pre-ribosomes from the nucleoplasm to the cytoplasm.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABR135C ^@ http://purl.uniprot.org/uniprot/Q75D89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR287C ^@ http://purl.uniprot.org/uniprot/Q74ZB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/284811:AGOS_AAR083C ^@ http://purl.uniprot.org/uniprot/Q75EJ6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/284811:AGOS_ADL387C ^@ http://purl.uniprot.org/uniprot/Q75BF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET5 subfamily.|||Cytoplasm|||Nucleus|||Putative protein lysine methyltransferase. http://togogenome.org/gene/284811:AGOS_ACL140C ^@ http://purl.uniprot.org/uniprot/Q75CQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.|||Cytoplasm|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. http://togogenome.org/gene/284811:AGOS_ADL399C ^@ http://purl.uniprot.org/uniprot/Q75BG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR059W ^@ http://purl.uniprot.org/uniprot/Q754L3 ^@ Similarity ^@ Belongs to the SF3B5 family. http://togogenome.org/gene/284811:AGOS_AFR404C ^@ http://purl.uniprot.org/uniprot/Q753Q4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).|||Nucleus|||The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity). http://togogenome.org/gene/284811:AGOS_AGL018C ^@ http://purl.uniprot.org/uniprot/Q750H1 ^@ Cofactor|||Similarity ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_AFR082C ^@ http://purl.uniprot.org/uniprot/Q754J2 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX31/DBP7 subfamily.|||Present with 1460 molecules/cell in log phase SD medium.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR402W ^@ http://purl.uniprot.org/uniprot/Q758X6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Mitochondrial GTPase involved in mitochondrial trafficking. Probably involved in control of anterograde transport of mitochondria and their subcellular distribution.|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AGR382W ^@ http://purl.uniprot.org/uniprot/Q74Z24 ^@ Function|||Similarity ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Catalyzes the transfer of a 4'-phosphopantetheine moiety from coenzyme A to a serine residue of acceptor proteins, such as alpha-aminoadipate reductase. Necessary for alpha-aminoadipate reductase activity (By similarity). http://togogenome.org/gene/284811:AGOS_ADL061W ^@ http://purl.uniprot.org/uniprot/Q75AI8 ^@ Function|||Similarity ^@ Belongs to the ARPC5 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Arp2/3 complex plays a critical role in the control of cell morphogenesis via the modulation of cell polarity development. http://togogenome.org/gene/284811:AGOS_ADR177C ^@ http://purl.uniprot.org/uniprot/Q759U6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR061W ^@ http://purl.uniprot.org/uniprot/Q754L1 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/284811:AGOS_ADL353C ^@ http://purl.uniprot.org/uniprot/Q75BC0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AER168C ^@ http://purl.uniprot.org/uniprot/Q756T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-alpha family.|||Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity). http://togogenome.org/gene/284811:AGOS_AGR200W ^@ http://purl.uniprot.org/uniprot/Q74ZK0 ^@ Similarity ^@ Belongs to the threonine aldolase family. http://togogenome.org/gene/284811:AGOS_AFR431C ^@ http://purl.uniprot.org/uniprot/Q752Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the second two steps of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylmonomethylethanolamine (PMME) to phosphatidyldimethylethanolamine (PDME) and of PDME to phosphatidylcholine (PC).|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ACL018W ^@ http://purl.uniprot.org/uniprot/Q75CC7 ^@ Similarity ^@ Belongs to the OPA3 family. http://togogenome.org/gene/284811:AGOS_ACR089C ^@ http://purl.uniprot.org/uniprot/Q75C28 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AER001C ^@ http://purl.uniprot.org/uniprot/Q757L1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/284811:AGOS_AEL272W ^@ http://purl.uniprot.org/uniprot/Q758M7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).|||Cytoplasm|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. http://togogenome.org/gene/284811:AGOS_AEL339C ^@ http://purl.uniprot.org/uniprot/Q758U1 ^@ Similarity ^@ Belongs to the OPI10 family. http://togogenome.org/gene/284811:AGOS_AGR249C ^@ http://purl.uniprot.org/uniprot/Q74ZF0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dUTPase family.|||Homotrimer.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/284811:AGOS_ABR194C ^@ http://purl.uniprot.org/uniprot/Q75D28 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/284811:AGOS_AER125C ^@ http://purl.uniprot.org/uniprot/Q756Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER264C ^@ http://purl.uniprot.org/uniprot/Q756W3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/284811:AGOS_AGL306C ^@ http://purl.uniprot.org/uniprot/Q751K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD4 family.|||Cell septum|||May be involved in the septin organization at the site of septation. http://togogenome.org/gene/284811:AGOS_AFL147C ^@ http://purl.uniprot.org/uniprot/Q755H0 ^@ Similarity ^@ Belongs to the Tango6 family. http://togogenome.org/gene/284811:AGOS_ADR360W ^@ http://purl.uniprot.org/uniprot/Q759B7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GIP4 family.|||Cytoplasm|||GLC7 phosphatase-regulatory protein involved in GLC7 subcellular redistribution and chromosome segregation.|||Interacts with GLC7. http://togogenome.org/gene/284811:AGOS_AGL263W ^@ http://purl.uniprot.org/uniprot/Q751G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the NTC complex (or PRP19-associated complex). The NTC complex associates with the spliceosome after the release of the U1 and U4 snRNAs and forms the CWC spliceosome subcomplex reminiscent of a late-stage spliceosome.|||Belongs to the CWC21 family.|||Cytoplasm|||Involved in pre-mRNA splicing. May function at or prior to the first catalytic step of splicing at the catalytic center of the spliceosome. May do so by stabilizing the catalytic center or the position of the RNA substrate (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL244W ^@ http://purl.uniprot.org/uniprot/Q758K6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_AAR038W ^@ http://purl.uniprot.org/uniprot/Q75EP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR333W ^@ http://purl.uniprot.org/uniprot/Q753H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAL147C ^@ http://purl.uniprot.org/uniprot/Q75F75 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/284811:AGOS_AER244C ^@ http://purl.uniprot.org/uniprot/Q756L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF1 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR025C ^@ http://purl.uniprot.org/uniprot/Q75EQ4 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_ADL128C ^@ http://purl.uniprot.org/uniprot/Q75AP8 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/284811:AGOS_ADL270C ^@ http://purl.uniprot.org/uniprot/Q75B47 ^@ Similarity ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family. http://togogenome.org/gene/284811:AGOS_ACR262C ^@ http://purl.uniprot.org/uniprot/Q75BK9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM23 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADR013W ^@ http://purl.uniprot.org/uniprot/Q75AA5 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Facilitates protein transport into the nucleus. Could be part of a multicomponent system of cytosolic factors that assemble at the pore complex during nuclear import (By similarity). http://togogenome.org/gene/284811:AGOS_AFR103W ^@ http://purl.uniprot.org/uniprot/Q754G7 ^@ Function|||Similarity ^@ Belongs to the IRS4 family.|||Positive regulator of phosphatidylinositol 4,5-bisphosphate turnover and negatively regulates signaling through the cell integrity pathway. Involved in rDNA silencing (By similarity). http://togogenome.org/gene/284811:AGOS_AFL051W ^@ http://purl.uniprot.org/uniprot/Q754W8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-Z subfamily.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR071W ^@ http://purl.uniprot.org/uniprot/Q75C46 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''. http://togogenome.org/gene/284811:AGOS_AFL206C ^@ http://purl.uniprot.org/uniprot/Q755M0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFR167W ^@ http://purl.uniprot.org/uniprot/Q754A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL220W ^@ http://purl.uniprot.org/uniprot/Q751C6 ^@ Similarity ^@ Belongs to the PAT1 family. http://togogenome.org/gene/284811:AGOS_AAL167W ^@ http://purl.uniprot.org/uniprot/Q75FA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAR043C ^@ http://purl.uniprot.org/uniprot/Q75EN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.|||Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ABR236W ^@ http://purl.uniprot.org/uniprot/Q75CY6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/284811:AGOS_AER007W ^@ http://purl.uniprot.org/uniprot/Q757K5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AAR162C ^@ http://purl.uniprot.org/uniprot/Q75ED6 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second.|||Pyruvate carboxylase catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/284811:AGOS_AFR433C ^@ http://purl.uniprot.org/uniprot/Q752Y8 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/284811:AGOS_AFR499C ^@ http://purl.uniprot.org/uniprot/Q752S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC24 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL370C ^@ http://purl.uniprot.org/uniprot/P41752 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/284811:AGOS_AGR025W ^@ http://purl.uniprot.org/uniprot/Q750D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL122W ^@ http://purl.uniprot.org/uniprot/Q750R4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/284811:AGOS_AAR121W ^@ http://purl.uniprot.org/uniprot/Q75EG0 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/284811:AGOS_AGL094W ^@ http://purl.uniprot.org/uniprot/Q750P2 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/284811:AGOS_AFL128C ^@ http://purl.uniprot.org/uniprot/Q755F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR327W ^@ http://purl.uniprot.org/uniprot/Q759F0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 28 family. http://togogenome.org/gene/284811:AGOS_AER412W ^@ http://purl.uniprot.org/uniprot/Q755V6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNAPIN family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex involved in endosomal cargo sorting.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).|||Endosome http://togogenome.org/gene/284811:AGOS_ACR181C ^@ http://purl.uniprot.org/uniprot/Q75BU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/284811:AGOS_ABR104W ^@ http://purl.uniprot.org/uniprot/Q75DC2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Required for tolerance to alcohol. http://togogenome.org/gene/284811:AGOS_ABR123W ^@ http://purl.uniprot.org/uniprot/Q75DA1 ^@ Similarity ^@ Belongs to the glutaminase PdxT/SNO family. http://togogenome.org/gene/284811:AGOS_ACR177W ^@ http://purl.uniprot.org/uniprot/Q75BU4 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/284811:AGOS_ABR152C ^@ http://purl.uniprot.org/uniprot/Q75D71 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/284811:AGOS_AFR647C ^@ http://purl.uniprot.org/uniprot/Q752C8 ^@ Function|||Similarity ^@ Catalyzes three sequential steps of tetrahydrofolate biosynthesis.|||In the C-terminal section; belongs to the DHPS family.|||In the N-terminal section; belongs to the DHNA family.|||In the central section; belongs to the HPPK family. http://togogenome.org/gene/284811:AGOS_AAR016W ^@ http://purl.uniprot.org/uniprot/Q75ER3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR251C ^@ http://purl.uniprot.org/uniprot/Q75BM0 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/284811:AGOS_ABR024C ^@ http://purl.uniprot.org/uniprot/Q75DJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role (via N-terminus) in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. Further stabilizes spliceosome conformation for 3'-splice site docking (via C-terminus) promoting exon ligation. http://togogenome.org/gene/284811:AGOS_AGL210C ^@ http://purl.uniprot.org/uniprot/Q750Z7 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AEL251C ^@ http://purl.uniprot.org/uniprot/Q758L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ATPase subunit B family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 17 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i/j and k (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER350W ^@ http://purl.uniprot.org/uniprot/Q756B7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer. http://togogenome.org/gene/284811:AGOS_AFR494W ^@ http://purl.uniprot.org/uniprot/Q752S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/284811:AGOS_ACL033C ^@ http://purl.uniprot.org/uniprot/Q75CF3 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the proteasome subunit S1 family. http://togogenome.org/gene/284811:AGOS_AEL142W ^@ http://purl.uniprot.org/uniprot/Q758A2 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/284811:AGOS_AFL229W ^@ http://purl.uniprot.org/uniprot/Q755P2 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily. http://togogenome.org/gene/284811:AGOS_ADR123W ^@ http://purl.uniprot.org/uniprot/Q75A00 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/284811:AGOS_ACL135W ^@ http://purl.uniprot.org/uniprot/Q75CQ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFL059C ^@ http://purl.uniprot.org/uniprot/Q754X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AGR097W ^@ http://purl.uniprot.org/uniprot/Q74ZV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR683C ^@ http://purl.uniprot.org/uniprot/Q751Z2 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR225C ^@ http://purl.uniprot.org/uniprot/Q74ZW4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AAL022W ^@ http://purl.uniprot.org/uniprot/Q75ET8 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/284811:AGOS_AGL136C ^@ http://purl.uniprot.org/uniprot/Q750S5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of a COP9 signalosome-like (CSN) complex.|||Component of the COP9 signalosome (CSN) complex that acts as a regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The complex is involved in the regulation of the mating pheromone response (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL003C ^@ http://purl.uniprot.org/uniprot/Q757L4 ^@ Caution|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by ESA1 to form H2AK4ac and H2AK7ac.|||Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.|||Nucleus|||Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).|||Sumoylation on Lys-126 may lead to transcriptional repression.|||The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-4; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-128. http://togogenome.org/gene/284811:AGOS_AGR288W ^@ http://purl.uniprot.org/uniprot/Q74ZB1 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/284811:AGOS_AER070C ^@ http://purl.uniprot.org/uniprot/Q757E3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Dus family. Dus3 subfamily.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Specifically modifies U47 in cytoplasmic tRNAs (By similarity). Catalyzes the synthesis of dihydrouridine in some mRNAs, thereby affecting their translation (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL148C ^@ http://purl.uniprot.org/uniprot/Q750T7 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/284811:AGOS_ADL319W ^@ http://purl.uniprot.org/uniprot/Q75B89 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FES1 family.|||Cytoplasm|||Functions as a nucleotide exchange factor (NEF) for Hsp70 chaperones which accelerates the release of ADP. Required for fully efficient Hsp70-mediated folding of proteins (By similarity). http://togogenome.org/gene/284811:AGOS_AFR366W ^@ http://purl.uniprot.org/uniprot/O74267 ^@ Similarity|||Subunit ^@ Belongs to the threonine aldolase family.|||Homotetramer. http://togogenome.org/gene/284811:AGOS_ADR029W ^@ http://purl.uniprot.org/uniprot/Q75A89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NRAP family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL086C ^@ http://purl.uniprot.org/uniprot/Q75CK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NST1 family.|||Cytoplasm|||May act as a negative regulator of salt tolerance. http://togogenome.org/gene/284811:AGOS_AFR243C ^@ http://purl.uniprot.org/uniprot/Q753T3 ^@ Cofactor|||Similarity ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit. http://togogenome.org/gene/284811:AGOS_AGL215W ^@ http://purl.uniprot.org/uniprot/Q751C1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM39 family.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_AGL157C ^@ http://purl.uniprot.org/uniprot/Q750U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/284811:AGOS_AEL299W ^@ http://purl.uniprot.org/uniprot/Q758Q2 ^@ Similarity ^@ Belongs to the YIP1 family. http://togogenome.org/gene/284811:AGOS_AGL063C ^@ http://purl.uniprot.org/uniprot/Q750M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR637W ^@ http://purl.uniprot.org/uniprot/Q752D9 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/284811:AGOS_ABR209W ^@ http://purl.uniprot.org/uniprot/Q75D13 ^@ Similarity ^@ Belongs to the anthranilate synthase component I family. http://togogenome.org/gene/284811:AGOS_AEL227C ^@ http://purl.uniprot.org/uniprot/Q758I9 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/284811:AGOS_ABR140C ^@ http://purl.uniprot.org/uniprot/Q75D84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. http://togogenome.org/gene/284811:AGOS_ACR289W ^@ http://purl.uniprot.org/uniprot/Q75BI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR217C ^@ http://purl.uniprot.org/uniprot/Q75D05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGR049W ^@ http://purl.uniprot.org/uniprot/Q750A8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL105W ^@ http://purl.uniprot.org/uniprot/Q750P7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex SPC19 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_ABL027W ^@ http://purl.uniprot.org/uniprot/Q75DP4 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/284811:AGOS_ACR154W ^@ http://purl.uniprot.org/uniprot/Q75BW7 ^@ Similarity ^@ Belongs to the beclin family. http://togogenome.org/gene/284811:AGOS_AER014W ^@ http://purl.uniprot.org/uniprot/Q757J9 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/284811:AGOS_ABL049C ^@ http://purl.uniprot.org/uniprot/Q75DR6 ^@ Similarity ^@ Belongs to the KTI12 family. http://togogenome.org/gene/284811:AGOS_AFR196C ^@ http://purl.uniprot.org/uniprot/Q753X6 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6A family. http://togogenome.org/gene/284811:AGOS_ADR377W ^@ http://purl.uniprot.org/uniprot/Q759A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA43 RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABL110W ^@ http://purl.uniprot.org/uniprot/Q75DY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AER177W ^@ http://purl.uniprot.org/uniprot/Q756S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TEC1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL272W ^@ http://purl.uniprot.org/uniprot/Q75B49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL089C ^@ http://purl.uniprot.org/uniprot/Q75B03 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/284811:AGOS_AER219C ^@ http://purl.uniprot.org/uniprot/Q756N5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL087W ^@ http://purl.uniprot.org/uniprot/Q75AL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Mitochondrion outer membrane|||Monomer. Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||NADH-dependent reductase for DPH3 and cytochrome b5. Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1. By reducing DPH3, also involved in the formation of the tRNA wobble base modification mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), mediated by the elongator complex. The cytochrome b5/NADH cytochrome b5 reductase electron transfer system supports the catalytic activity of several sterol biosynthetic enzymes. http://togogenome.org/gene/284811:AGOS_AFR074C ^@ http://purl.uniprot.org/uniprot/Q754J8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HEATR1/UTP10 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Involved in ribosome biosynthesis (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL064W ^@ http://purl.uniprot.org/uniprot/Q750M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR202W ^@ http://purl.uniprot.org/uniprot/Q74ZJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Involved in the initiation of assembly of the COPII coat required for the formation of transport vesicles from the endoplasmic reticulum (ER) and the selection of cargo molecules. Also involved in autophagy (By similarity). http://togogenome.org/gene/284811:AGOS_ABR125C ^@ http://purl.uniprot.org/uniprot/Q75D99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAL133W ^@ http://purl.uniprot.org/uniprot/Q75F61 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFL027C ^@ http://purl.uniprot.org/uniprot/Q754U8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved spliceosome assembly and in nuclear splicing. Catalyzes an ATP-dependent conformational change of U2 snRNP. Bridges U1 and U2 snRNPs and enables stable U2 snRNP association with intron RNA (By similarity).|||Belongs to the DEAD box helicase family. DDX46/PRP5 subfamily.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_ABL128W ^@ http://purl.uniprot.org/uniprot/Q75E01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF8 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR216W ^@ http://purl.uniprot.org/uniprot/Q75D06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion inner membrane|||Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. http://togogenome.org/gene/284811:AGOS_AGR281C ^@ http://purl.uniprot.org/uniprot/Q74ZB8 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/284811:AGOS_AFR312W ^@ http://purl.uniprot.org/uniprot/Q753K0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL213W ^@ http://purl.uniprot.org/uniprot/Q758H5 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/284811:AGOS_AER044W ^@ http://purl.uniprot.org/uniprot/Q757G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC6 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL074C ^@ http://purl.uniprot.org/uniprot/Q754Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR299W ^@ http://purl.uniprot.org/uniprot/Q74ZA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETT1 family.|||Nucleus|||Required for correct translation termination and probably involved in regulation of hypoxic gene expression. http://togogenome.org/gene/284811:AGOS_ACR221W ^@ http://purl.uniprot.org/uniprot/Q75BQ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/284811:AGOS_AFR474W ^@ http://purl.uniprot.org/uniprot/Q752U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL100W ^@ http://purl.uniprot.org/uniprot/Q755C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase. http://togogenome.org/gene/284811:AGOS_ADR201W ^@ http://purl.uniprot.org/uniprot/Q759S2 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/284811:AGOS_ADR141W ^@ http://purl.uniprot.org/uniprot/Q759Y2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the palI/RIM9 family.|||Cell membrane|||Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. http://togogenome.org/gene/284811:AGOS_AER388C ^@ http://purl.uniprot.org/uniprot/Q755Y0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Early endosome membrane|||Golgi apparatus membrane|||Palmitoyltransferase specific for casein kinase 1.|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284811:AGOS_AGR332C ^@ http://purl.uniprot.org/uniprot/Q74Z74 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFR075C ^@ http://purl.uniprot.org/uniprot/Q754J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ThrE exporter (TC 2.A.79) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL214C ^@ http://purl.uniprot.org/uniprot/Q758H6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2H phosphoesterase superfamily. CPD1 family.|||Golgi apparatus|||Involved in the metabolism of ADP-ribose 1',2'-cyclic phosphate which is produced as a consequence of tRNA splicing. http://togogenome.org/gene/284811:AGOS_AEL186W ^@ http://purl.uniprot.org/uniprot/Q758E8 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ACR093C ^@ http://purl.uniprot.org/uniprot/Q75C24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BIG1 family.|||Endoplasmic reticulum membrane|||Required for normal beta-1,6-glucan synthesis. http://togogenome.org/gene/284811:AGOS_AGR218C ^@ http://purl.uniprot.org/uniprot/Q74ZI4 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/284811:AGOS_AFR502C ^@ http://purl.uniprot.org/uniprot/Q752S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR273C ^@ http://purl.uniprot.org/uniprot/Q74ZC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/284811:AGOS_AAL163W ^@ http://purl.uniprot.org/uniprot/Q75F94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL076C ^@ http://purl.uniprot.org/uniprot/Q757T8 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/284811:AGOS_AFR360W ^@ http://purl.uniprot.org/uniprot/Q753F4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme c group covalently per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain (By similarity).|||Mitochondrion intermembrane space http://togogenome.org/gene/284811:AGOS_ADR098C ^@ http://purl.uniprot.org/uniprot/Q75A22 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/284811:AGOS_AAL017W ^@ http://purl.uniprot.org/uniprot/Q876Z1 ^@ Similarity ^@ Belongs to the UPF0357 family. http://togogenome.org/gene/284811:AGOS_AGL154W ^@ http://purl.uniprot.org/uniprot/Q750U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC37 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AAL063C ^@ http://purl.uniprot.org/uniprot/Q75EZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL010W ^@ http://purl.uniprot.org/uniprot/Q750G3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase important for chromosome transmission and normal cell cycle progression in G(2)/M (By similarity). May have a role in changing DNA topology to allow the loading of proteins involved in maintaining sister chromatid cohesion in the vicinity of the centromeres (By similarity). Has a specific role in chromosome segregation during meiosis II (By similarity).|||Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL109C ^@ http://purl.uniprot.org/uniprot/Q75CM8 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Homodimer.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/284811:AGOS_ACR021W ^@ http://purl.uniprot.org/uniprot/Q75C95 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/284811:AGOS_ABL057W ^@ http://purl.uniprot.org/uniprot/Q75DT3 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/284811:AGOS_AFR302W ^@ http://purl.uniprot.org/uniprot/Q753L0 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/284811:AGOS_AFR734C ^@ http://purl.uniprot.org/uniprot/Q751U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Component of the nucleolar and nucleoplasmic pre-60S ribosomal particle.|||Required for proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER382W ^@ http://purl.uniprot.org/uniprot/Q755Y5 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_ACL183W ^@ http://purl.uniprot.org/uniprot/Q75CX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM21 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to keep the TOM and the TIM23 complexes in close contact. At some point, it is released from the TOM23 complex to allow protein translocation into the mitochondrial matrix (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AAL151C ^@ http://purl.uniprot.org/uniprot/Q75F79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AER343C ^@ http://purl.uniprot.org/uniprot/Q756C4 ^@ Similarity ^@ Belongs to the EFR3 family. http://togogenome.org/gene/284811:AGOS_ADL179C ^@ http://purl.uniprot.org/uniprot/Q75AU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AER379C ^@ http://purl.uniprot.org/uniprot/Q755Y8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR498W ^@ http://purl.uniprot.org/uniprot/Q752S5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/284811:AGOS_AER246W ^@ http://purl.uniprot.org/uniprot/Q756K8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Methyltransferase which mediates trimethylation of cytochrome c (CYC1).|||The SET-like region, although related with the SET domain is not detected by any prediction method.|||cytosol http://togogenome.org/gene/284811:AGOS_ACR124W ^@ http://purl.uniprot.org/uniprot/Q75BZ5 ^@ Similarity ^@ Belongs to the dihydrofolate reductase family. http://togogenome.org/gene/284811:AGOS_ADL188C ^@ http://purl.uniprot.org/uniprot/Q75AV8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic initiation factor 4E family.|||Recognizes and binds the 7-methylguanosine-containing mRNA cap during an early step in the initiation of protein synthesis and facilitates ribosome binding by inducing the unwinding of the mRNAs secondary structures.|||eIF4F is a multi-subunit complex, the composition of which varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G. eIF4E is also known to interact with other partners (By similarity). http://togogenome.org/gene/284811:AGOS_AFL063W ^@ http://purl.uniprot.org/uniprot/Q754X9 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/284811:AGOS_ACL083C ^@ http://purl.uniprot.org/uniprot/Q75CK2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/284811:AGOS_AGR298C ^@ http://purl.uniprot.org/uniprot/Q74ZA5 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/284811:AGOS_ACR182C ^@ http://purl.uniprot.org/uniprot/Q75BT9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutamine synthetase family.|||Cytoplasm|||Homooctamer. http://togogenome.org/gene/284811:AGOS_AFR547W ^@ http://purl.uniprot.org/uniprot/Q752M7 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family. http://togogenome.org/gene/284811:AGOS_ADL054W ^@ http://purl.uniprot.org/uniprot/Q75AI1 ^@ Function|||Similarity ^@ Belongs to the WD repeat DSE1 family.|||Involved in cell wall metabolism and required for the separation of the mother and daughter cells. http://togogenome.org/gene/284811:AGOS_ABR007C ^@ http://purl.uniprot.org/uniprot/Q75DS4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments (By similarity).|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/284811:AGOS_AER433W ^@ http://purl.uniprot.org/uniprot/Q755T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHZ1 family.|||Forms a chaperone-bound H2A.Z-H2B complex that acts as a source for SWR1 complex-dependent H2A to H2A.Z histone replacement in chromatin.|||Forms a heterotrimer with H2A.Z-H2B, stabilizing the association of the histone dimer. Also, with a lower affinity, forms a heterotrimer with H2A-H2B (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL258W ^@ http://purl.uniprot.org/uniprot/Q75B35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER270W ^@ http://purl.uniprot.org/uniprot/Q756J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AER450C ^@ http://purl.uniprot.org/uniprot/Q755R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL062C ^@ http://purl.uniprot.org/uniprot/Q750L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF5 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR088W ^@ http://purl.uniprot.org/uniprot/Q75EJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG8 family.|||Mitochondrion|||Required for respiratory activity and maintenance and expression of the mitochondrial genome. http://togogenome.org/gene/284811:AGOS_AFR165C ^@ http://purl.uniprot.org/uniprot/Q754A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR583W ^@ http://purl.uniprot.org/uniprot/Q752J2 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/284811:AGOS_AFL180C ^@ http://purl.uniprot.org/uniprot/Q755Q8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL107W ^@ http://purl.uniprot.org/uniprot/Q757W9 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/284811:AGOS_ADL185W ^@ http://purl.uniprot.org/uniprot/Q75AV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER323W ^@ http://purl.uniprot.org/uniprot/Q756F6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the SRB8-11 complex, which itself associates with the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL198W ^@ http://purl.uniprot.org/uniprot/Q75CW4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR037C ^@ http://purl.uniprot.org/uniprot/Q750C0 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFL220C ^@ http://purl.uniprot.org/uniprot/Q755Q7 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/284811:AGOS_ADR304W ^@ http://purl.uniprot.org/uniprot/Q759I4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STE12 transcription factor family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER410W ^@ http://purl.uniprot.org/uniprot/Q755V8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/284811:AGOS_ADR336C ^@ http://purl.uniprot.org/uniprot/Q759E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL166W ^@ http://purl.uniprot.org/uniprot/Q75AT6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/284811:AGOS_AFR332W ^@ http://purl.uniprot.org/uniprot/Q753I0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS4/SLD5 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). http://togogenome.org/gene/284811:AGOS_AAR002W ^@ http://purl.uniprot.org/uniprot/Q75ES7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/284811:AGOS_ACR190C ^@ http://purl.uniprot.org/uniprot/Q75BT1 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/284811:AGOS_ADR258W ^@ http://purl.uniprot.org/uniprot/Q759L8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/284811:AGOS_AER374C ^@ http://purl.uniprot.org/uniprot/Q755Z3 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR260C ^@ http://purl.uniprot.org/uniprot/Q759L6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in transcription elongation and required for the export of mRNA out of the nucleus. SUB2 also plays a role in pre-mRNA splicing and spliceosome assembly. May be involved in rDNA and telomeric silencing, and maintenance of genome integrity (By similarity).|||Belongs to the DEAD box helicase family. DECD subfamily.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AAL074C ^@ http://purl.uniprot.org/uniprot/Q75F02 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Mitochondrion|||Necessary for protein synthesis in mitochondria. Functions as a ribosome recycling factor in mitochondria (By similarity). http://togogenome.org/gene/284811:AGOS_ADL131C ^@ http://purl.uniprot.org/uniprot/Q75AQ1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/284811:AGOS_ADL035C ^@ http://purl.uniprot.org/uniprot/Q75AF2 ^@ Function|||Similarity ^@ Accepts the ubiquitin-like protein NEDD8/RUB1 from the UBA3-ULA1 E1 complex and catalyzes its covalent attachment to other proteins.|||Belongs to the ubiquitin-conjugating enzyme family. UBC12 subfamily. http://togogenome.org/gene/284811:AGOS_ACL111W ^@ http://purl.uniprot.org/uniprot/Q75CN0 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/284811:AGOS_ACR213W ^@ http://purl.uniprot.org/uniprot/Q75BQ8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/284811:AGOS_AEL330C ^@ http://purl.uniprot.org/uniprot/Q758T2 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Probable serine/threonine protein kinase which may function redundantly with MPK1-independent branch of the PCK1 pathway. http://togogenome.org/gene/284811:AGOS_ADR058C ^@ http://purl.uniprot.org/uniprot/Q75A61 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AEL145W ^@ http://purl.uniprot.org/uniprot/Q758D6 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR425C ^@ http://purl.uniprot.org/uniprot/Q752Z9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Nucleus|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/284811:AGOS_AFL116W ^@ http://purl.uniprot.org/uniprot/Q755D9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/284811:AGOS_ADR061C ^@ http://purl.uniprot.org/uniprot/Q75A58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AMN1 family.|||Cytoplasm|||Negative regulator of the mitotic exit network (MEN), required for multiple cell cycle checkpoints. Required for daughter cell separation and chromosome stability. Involved in copper sensitivity.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL332W ^@ http://purl.uniprot.org/uniprot/Q751M9 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/284811:AGOS_AEL212W ^@ http://purl.uniprot.org/uniprot/Q758H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR219W ^@ http://purl.uniprot.org/uniprot/Q74ZI3 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR401C ^@ http://purl.uniprot.org/uniprot/Q758X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AFR064C ^@ http://purl.uniprot.org/uniprot/Q754K8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. FKBP1 subfamily.|||Cytoplasm|||Inhibited by both FK506 and rapamycin.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/284811:AGOS_AER296W ^@ http://purl.uniprot.org/uniprot/Q756H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AAL005W ^@ http://purl.uniprot.org/uniprot/Q75EU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ABL205C ^@ http://purl.uniprot.org/uniprot/Q75E78 ^@ Function|||Similarity ^@ Belongs to the NARF family.|||Component of the cytosolic Fe/S protein assembly machinery. Required for maturation of extramitochondrial Fe/S proteins. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity). http://togogenome.org/gene/284811:AGOS_AGL118W ^@ http://purl.uniprot.org/uniprot/Q750R0 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/284811:AGOS_AAR177W ^@ http://purl.uniprot.org/uniprot/Q75EA0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/284811:AGOS_ABR036W ^@ http://purl.uniprot.org/uniprot/Q75DI8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_AFR248C ^@ http://purl.uniprot.org/uniprot/Q753S8 ^@ Function|||Similarity ^@ Belongs to the IRC6 family.|||Involved in gross chromosomal rearrangements (GCRs) and telomere healing. http://togogenome.org/gene/284811:AGOS_ACR170C ^@ http://purl.uniprot.org/uniprot/Q75BV1 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. UMP-CMP kinase subfamily.|||Binds 1 Mg(2+) ion per monomer.|||Catalyzes the phosphorylation of pyrimidine nucleoside monophosphates at the expense of ATP. Plays an important role in de novo pyrimidine nucleotide biosynthesis. Has preference for UMP and dUMP as phosphate acceptors, but can also use CMP, dCMP and AMP.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR389C ^@ http://purl.uniprot.org/uniprot/Q74Z17 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_ABR163W ^@ http://purl.uniprot.org/uniprot/Q75D60 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/284811:AGOS_AER096C ^@ http://purl.uniprot.org/uniprot/Q757B7 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the calcineurin regulatory subunit family.|||Composed of a catalytic subunit (A) and a regulatory subunit (B).|||Regulatory subunit of calcineurin, a calcium-dependent, calmodulin stimulated protein phosphatase. Confers calcium sensitivity (By similarity).|||This protein has four functional calcium-binding sites. http://togogenome.org/gene/284811:AGOS_AGL267C ^@ http://purl.uniprot.org/uniprot/Q751H3 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/284811:AGOS_AFL006C ^@ http://purl.uniprot.org/uniprot/Q754S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER372C ^@ http://purl.uniprot.org/uniprot/Q755Z5 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/284811:AGOS_ADL284C ^@ http://purl.uniprot.org/uniprot/Q75B56 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/284811:AGOS_AFL218C ^@ http://purl.uniprot.org/uniprot/Q755N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TrkH potassium transport family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR076C ^@ http://purl.uniprot.org/uniprot/Q75DF0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AGR272W ^@ http://purl.uniprot.org/uniprot/Q74ZC7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL060W ^@ http://purl.uniprot.org/uniprot/Q750L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Peroxisome http://togogenome.org/gene/284811:AGOS_AEL085W ^@ http://purl.uniprot.org/uniprot/Q757U7 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/284811:AGOS_AER415W ^@ http://purl.uniprot.org/uniprot/Q755V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AAR042W ^@ http://purl.uniprot.org/uniprot/Q75EN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SHE3 family.|||Endoplasmic reticulum membrane|||RNA-binding protein that binds specific mRNAs including the ASH1 mRNA, coding for a repressor of the HO endonuclease. Part of the mRNA localization machinery that restricts accumulation of certain proteins to the bud and in the daughter cell. Required for the delivery of cortical endoplasmic reticulum into the emerging bud (By similarity). http://togogenome.org/gene/284811:AGOS_ADL002C ^@ http://purl.uniprot.org/uniprot/Q75AB9 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/284811:AGOS_ADL194W ^@ http://purl.uniprot.org/uniprot/Q75AW4 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. May methylate the carboxyl group of leucine residues to form alpha-leucine ester residues (By similarity). http://togogenome.org/gene/284811:AGOS_ACL019C ^@ http://purl.uniprot.org/uniprot/Q75CC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HRD1 family.|||E3 ubiquitin-protein ligase which accepts ubiquitin specifically from endoplasmic reticulum-associated E2 ligases, and transfers it to substrates promoting their degradation. Mediates the degradation of endoplasmic reticulum proteins (ERQC), also called ER-associated degradation (ERAD). Component of the HRD1 ubiquitin ligase complex, which is part of the ERAD-L and ERAD-M pathways responsible for the rapid degradation of soluble lumenal and membrane proteins with misfolded lumenal domains (ERAD-L), or ER-membrane proteins with misfolded transmembrane domains (ERAD-M) (By similarity).|||Endoplasmic reticulum membrane|||Interacts with HRD3. http://togogenome.org/gene/284811:AGOS_ADL032W ^@ http://purl.uniprot.org/uniprot/Q75AE9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFL012C ^@ http://purl.uniprot.org/uniprot/Q754T3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. It probably carries the active site for 3'-splice site cleavage (By similarity).|||Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN15 (By similarity). http://togogenome.org/gene/284811:AGOS_ADL137W ^@ http://purl.uniprot.org/uniprot/Q75AQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTC6 family.|||May be involved in telomere capping.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL134W ^@ http://purl.uniprot.org/uniprot/Q757Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE9/KNH1 family.|||Involved in cell wall beta(1->6) glucan synthesis.|||cell wall http://togogenome.org/gene/284811:AGOS_ACL099W ^@ http://purl.uniprot.org/uniprot/Q75CL8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER124W ^@ http://purl.uniprot.org/uniprot/Q756Z0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Inhibited by organophosphorus esters.|||Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity). http://togogenome.org/gene/284811:AGOS_AFR530W ^@ http://purl.uniprot.org/uniprot/Q752P3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/284811:AGOS_AAR061W ^@ http://purl.uniprot.org/uniprot/Q75EL8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/284811:AGOS_ACR191C ^@ http://purl.uniprot.org/uniprot/Q75BT0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/284811:AGOS_AGL013W ^@ http://purl.uniprot.org/uniprot/Q750G6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/284811:AGOS_AAR153C ^@ http://purl.uniprot.org/uniprot/Q75EC1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Expected to bind 2 Fe(2+) ions per subunit.|||Membrane|||Stearoyl-CoA desaturase that utilizes O(2) and electrons from reduced cytochrome b5 to introduce the first double bond into saturated fatty acyl-CoA substrates. http://togogenome.org/gene/284811:AGOS_AAL160W ^@ http://purl.uniprot.org/uniprot/Q75FA2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Cytoplasm|||Homotrimer.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR010C ^@ http://purl.uniprot.org/uniprot/Q8J1G7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.|||Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediated by KAR3 (By similarity).|||spindle http://togogenome.org/gene/284811:AGOS_AGL107W ^@ http://purl.uniprot.org/uniprot/Q750P9 ^@ Similarity ^@ Belongs to the LipB family. http://togogenome.org/gene/284811:AGOS_ADR387W ^@ http://purl.uniprot.org/uniprot/Q758Z0 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/284811:AGOS_AGR100W ^@ http://purl.uniprot.org/uniprot/Q74ZU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL199W ^@ http://purl.uniprot.org/uniprot/Q75AW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S-adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86. http://togogenome.org/gene/284811:AGOS_AGL129W ^@ http://purl.uniprot.org/uniprot/Q750R8 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/284811:AGOS_AER259W ^@ http://purl.uniprot.org/uniprot/Q756J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||Involved in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL299C ^@ http://purl.uniprot.org/uniprot/Q751K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the ALG3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ACR095W ^@ http://purl.uniprot.org/uniprot/Q75C22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Chromosome|||Could act as an H1-type linker histone.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER368C ^@ http://purl.uniprot.org/uniprot/Q755Z9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSM2 family.|||Cytoplasm|||Involved in chromosome segregation during meiosis. Promotes efficient recombinational repair and functions in the protection of the genome from spontaneous and induced DNA damage like mutations and gross chromosomal rearrangements (GCRs) (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR204W ^@ http://purl.uniprot.org/uniprot/Q74ZJ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRO1 family.|||Cytoplasm|||Endosome|||Involved in concentration and sorting of cargo proteins of the multivesicular body (MVB) for incorporation into intralumenal vesicles. http://togogenome.org/gene/284811:AGOS_AER012C ^@ http://purl.uniprot.org/uniprot/Q757K0|||http://purl.uniprot.org/uniprot/Q75AX1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). http://togogenome.org/gene/284811:AGOS_AFR409W ^@ http://purl.uniprot.org/uniprot/Q753B5 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/284811:AGOS_AGR121C ^@ http://purl.uniprot.org/uniprot/Q74ZS7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_AFR120C ^@ http://purl.uniprot.org/uniprot/Q754F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||May be involved in cellular response to stress. Required to maintain mitochondrial DNA (mtDNA) integrity and stability (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR408C ^@ http://purl.uniprot.org/uniprot/Q753B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Part of the multisubunit TRAPP (transport protein particle) complex.|||Plays a key role in the late stages of endoplasmic reticulum to Golgi traffic.|||cis-Golgi network http://togogenome.org/gene/284811:AGOS_AFR067W ^@ http://purl.uniprot.org/uniprot/Q754K5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin. http://togogenome.org/gene/284811:AGOS_ABR069W ^@ http://purl.uniprot.org/uniprot/Q75DF7 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/284811:AGOS_AER314W ^@ http://purl.uniprot.org/uniprot/Q756F1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL124W ^@ http://purl.uniprot.org/uniprot/Q75F52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/284811:AGOS_ABR003W ^@ http://purl.uniprot.org/uniprot/Q75DL5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/284811:AGOS_ACL113C ^@ http://purl.uniprot.org/uniprot/Q75CN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YPP1 family.|||Cell membrane|||Cytoplasmic granule|||Involved in endocytosis. http://togogenome.org/gene/284811:AGOS_AAL122C ^@ http://purl.uniprot.org/uniprot/Q75F50 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/284811:AGOS_AFL168W ^@ http://purl.uniprot.org/uniprot/Q755J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER228C ^@ http://purl.uniprot.org/uniprot/Q756M6 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/284811:AGOS_AFL133C ^@ http://purl.uniprot.org/uniprot/Q755F6 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/284811:AGOS_ACL015W ^@ http://purl.uniprot.org/uniprot/Q75CC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER333C ^@ http://purl.uniprot.org/uniprot/Q756D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI19 family.|||Component of the phosphatidylinositol N-acetylglucosaminyltransferase complex.|||Endoplasmic reticulum membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. Involved in cell wall biosynthesis (By similarity). http://togogenome.org/gene/284811:AGOS_ABR043W ^@ http://purl.uniprot.org/uniprot/Q75DI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL114C ^@ http://purl.uniprot.org/uniprot/Q750Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABL180W ^@ http://purl.uniprot.org/uniprot/Q75E50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAP1 family.|||Homodimer.|||Involved in the regulation of telomere length, clustering and has a specific role in telomere position effect (TPE).|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AER034C ^@ http://purl.uniprot.org/uniprot/Q757H9 ^@ Similarity ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily. http://togogenome.org/gene/284811:AGOS_AEL148W ^@ http://purl.uniprot.org/uniprot/Q758D4 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AAL078W ^@ http://purl.uniprot.org/uniprot/Q75F06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER309W ^@ http://purl.uniprot.org/uniprot/Q756F7 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/284811:AGOS_AER013W ^@ http://purl.uniprot.org/uniprot/Q757N1 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of histone H3 leads to transcriptional activation. H3K14ac formation by GCN5 is promoted by H3S10ph. H3K14ac can also be formed by ESA1. H3K56ac formation occurs predominantly in newly synthesized H3 molecules during G1, S and G2/M of the cell cycle and may be involved in DNA repair (By similarity).|||Belongs to the histone H3 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Mono-, di- and trimethylated by the COMPASS complex to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. Methylated by SET2 to form H3K36me. H3K36me represses gene expression. Methylated by DOT1 to form H3K79me. H3K79me is required for association of SIR proteins with telomeric regions and for telomeric silencing. The COMPASS-mediated formation of H3K4me2/3 and the DOT1-mediated formation of H3K79me require H2BK123ub1 (By similarity).|||Nucleus|||Phosphorylated by IPL1 to form H3S10ph. H3S10ph promotes subsequent H3K14ac formation by GCN5 and is required for transcriptional activation through TBP recruitment to the promoters (By similarity).|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity).|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3S10ph = phosphorylated Ser-11; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-37; H3K36me1/2/3 = mono-, di- and trimethylated Lys-37; H3K56ac = acetylated Lys-57; H3K64ac = acetylated Lys-65; H3K79me1/2/3 = mono-, di- and trimethylated Lys-80. http://togogenome.org/gene/284811:AGOS_ADR231C ^@ http://purl.uniprot.org/uniprot/Q759P4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PLPL family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lipid hydrolase.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR598C ^@ http://purl.uniprot.org/uniprot/Q752H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL252W ^@ http://purl.uniprot.org/uniprot/Q9HF51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family.|||Cell membrane|||Involved in the regulation of actin polarization. Rho proteins are required for distinct steps during polarized hyphal growth of A.gossypii. http://togogenome.org/gene/284811:AGOS_AFR100W ^@ http://purl.uniprot.org/uniprot/Q754H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EXO70 family.|||Bud|||Bud neck|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Also plays a role in the assembly of the exocyst (By similarity). http://togogenome.org/gene/284811:AGOS_AFR116W ^@ http://purl.uniprot.org/uniprot/Q754F4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferric reductase (FRE) family. AIM14 subfamily.|||Membrane|||Probable cell surface metalloreductase. May be involved in iron or copper homeostasis (By similarity). http://togogenome.org/gene/284811:AGOS_AGR222W ^@ http://purl.uniprot.org/uniprot/Q74ZI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/284811:AGOS_AAL175W ^@ http://purl.uniprot.org/uniprot/Q75F91 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABL093W ^@ http://purl.uniprot.org/uniprot/Q75DW6 ^@ Similarity ^@ Belongs to the VPS54 family. http://togogenome.org/gene/284811:AGOS_AFL120W ^@ http://purl.uniprot.org/uniprot/Q755E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL090W ^@ http://purl.uniprot.org/uniprot/Q755B5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AGL089W ^@ http://purl.uniprot.org/uniprot/Q750N9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AFL167C ^@ http://purl.uniprot.org/uniprot/Q755J0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 63 family. http://togogenome.org/gene/284811:AGOS_AFR403W ^@ http://purl.uniprot.org/uniprot/Q753Q5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/284811:AGOS_ADL046C ^@ http://purl.uniprot.org/uniprot/Q75AG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm|||Multifunctional protein that exhibits several independent functions at different levels of the cellular processes. 5'-3' exonuclease component of the nonsense-mediated mRNA decay (NMD) which is a highly conserved mRNA degradation pathway, an RNA surveillance system whose role is to identify and rid cells of mRNA with premature termination codons and thus prevents accumulation of potentially harmful truncated proteins. http://togogenome.org/gene/284811:AGOS_ACR206C ^@ http://purl.uniprot.org/uniprot/Q75BR5 ^@ Similarity ^@ Belongs to the complex I LYR family. SDHAF1 subfamily. http://togogenome.org/gene/284811:AGOS_ADR050W ^@ http://purl.uniprot.org/uniprot/Q75A68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR645W ^@ http://purl.uniprot.org/uniprot/Q752D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGR371C ^@ http://purl.uniprot.org/uniprot/Q74Z35 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/284811:AGOS_AFR436C ^@ http://purl.uniprot.org/uniprot/Q752Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_AGL053C ^@ http://purl.uniprot.org/uniprot/Q750K4 ^@ Similarity ^@ Belongs to the TACO1 family. http://togogenome.org/gene/284811:AGOS_AGL005W ^@ http://purl.uniprot.org/uniprot/Q750F9 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. ULA1 subfamily.|||Regulatory subunit of the dimeric UBA3-ULA1 E1 enzyme. http://togogenome.org/gene/284811:AGOS_ACL013C ^@ http://purl.uniprot.org/uniprot/Q75CC2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM12 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. A MMM1 homodimer associates with one molecule of MDM12 on each side in a pairwise head-to-tail manner, and the SMP-LTD domains of MMM1 and MDM12 generate a continuous hydrophobic tunnel for phospholipid trafficking.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum (ER) and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis, and function in nonvesicular lipid trafficking between the ER and mitochondria. MDM12 is required for the interaction of the ER-resident membrane protein MMM1 and the outer mitochondrial membrane-resident beta-barrel protein MDM10. The MDM12-MMM1 subcomplex functions in the major beta-barrel assembly pathway that is responsible for biogenesis of all mitochondrial outer membrane beta-barrel proteins, and acts in a late step after the SAM complex. The MDM10-MDM12-MMM1 subcomplex further acts in the TOM40-specific pathway after the action of the MDM12-MMM1 complex. Essential for establishing and maintaining the structure of mitochondria and maintenance of mtDNA nucleoids.|||Endoplasmic reticulum membrane|||Mitochondrion outer membrane|||The SMP-LTD domain is a barrel-like domain that can bind various types of glycerophospholipids in its interior and mediate their transfer between two adjacent bilayers. http://togogenome.org/gene/284811:AGOS_ADR059C ^@ http://purl.uniprot.org/uniprot/Q75A60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Component of the microsomal membrane bound fatty acid elongation system, which produces the 26-carbon very long-chain fatty acids (VLCFA) from palmitate. Catalyzes the reduction of the 3-ketoacyl-CoA intermediate that is formed in each cycle of fatty acid elongation. VLCFAs serve as precursors for ceramide and sphingolipids.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AER031C ^@ http://purl.uniprot.org/uniprot/Q757I2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/284811:AGOS_AFR213C ^@ http://purl.uniprot.org/uniprot/Q753V9 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/284811:AGOS_AEL301W ^@ http://purl.uniprot.org/uniprot/Q758Q4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR308W ^@ http://purl.uniprot.org/uniprot/Q753K4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SYF2 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER162C ^@ http://purl.uniprot.org/uniprot/Q756U0 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/284811:AGOS_AGR184W ^@ http://purl.uniprot.org/uniprot/Q74ZL4 ^@ Caution|||Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by ESA1 to form H2AK4ac and H2AK7ac.|||Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome which plays a central role in DNA double strand break (DSB) repair. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||In contrast to vertebrates and insects, its C-terminus is not monoubiquitinated.|||Nucleus|||Phosphorylated to form H2AS128ph (gamma-H2A) in response to DNA double-strand breaks (DSBs) generated by exogenous genotoxic agents and by stalled replication forks. Phosphorylation is dependent on the DNA damage checkpoint kinases MEC1/ATR and TEL1/ATM, spreads on either side of a detected DSB site and may mark the surrounding chromatin for recruitment of proteins required for DNA damage signaling and repair. Gamma-H2A is removed from the DNA prior to the strand invasion-primer extension step of the repair process and subsequently dephosphorylated by PPH3, a component of the histone H2A phosphatase complex (HTP-C). Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).|||Sumoylation on Lys-126 may lead to transcriptional repression.|||The [ST]-Q motif constitutes a recognition sequence for kinases from the PI3/PI4-kinase family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2AK4ac = acetylated Lys-4; H2AK7ac = acetylated Lys-7; H2AS128ph = phosphorylated Ser-128. http://togogenome.org/gene/284811:AGOS_AEL294C ^@ http://purl.uniprot.org/uniprot/Q758P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL026W ^@ http://purl.uniprot.org/uniprot/Q750H7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL015W ^@ http://purl.uniprot.org/uniprot/Q757M3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NUF2 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/284811:AGOS_AFL047W ^@ http://purl.uniprot.org/uniprot/Q754W4 ^@ Similarity ^@ Belongs to the class-I DAHP synthase family. http://togogenome.org/gene/284811:AGOS_ADL155C ^@ http://purl.uniprot.org/uniprot/Q75AS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR019W ^@ http://purl.uniprot.org/uniprot/Q754Q3 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/284811:AGOS_ACL203C ^@ http://purl.uniprot.org/uniprot/Q75CW9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL199W ^@ http://purl.uniprot.org/uniprot/Q758G1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERF4 family.|||Endoplasmic reticulum membrane|||Interacts with ERF2.|||The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. Palmitoylates RAS2, which is required for its proper plasma membrane localization (By similarity). http://togogenome.org/gene/284811:AGOS_AGL194C ^@ http://purl.uniprot.org/uniprot/Q750Y3 ^@ Function ^@ May contribute to neddylation of cullin components of SCF-type E3 ubiquitin ligase complexes. Neddylation of cullins play an essential role in the regulation of SCF-type complexes activity (By similarity). http://togogenome.org/gene/284811:AGOS_ACL178C ^@ http://purl.uniprot.org/uniprot/Q75CU7 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. uL10 forms part of the P stalk that participates in recruiting G proteins to the ribosome. http://togogenome.org/gene/284811:AGOS_AER327C ^@ http://purl.uniprot.org/uniprot/Q756E0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR023C ^@ http://purl.uniprot.org/uniprot/Q750D2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_AFR134C ^@ http://purl.uniprot.org/uniprot/Q754D6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/284811:AGOS_AGR368W ^@ http://purl.uniprot.org/uniprot/Q74Z38 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/284811:AGOS_ABR170W ^@ http://purl.uniprot.org/uniprot/Q75D53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GcvT family. CAF17 subfamily.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADL299C ^@ http://purl.uniprot.org/uniprot/Q75B71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which plays an essential role in the initiation of DNA synthesis.|||Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR093C ^@ http://purl.uniprot.org/uniprot/Q75DD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL273C ^@ http://purl.uniprot.org/uniprot/Q75B50 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in translation initiation. Remodels RNA in response to ADP and ATP concentrations by facilitating disruption, but also formation of RNA duplexes (By similarity).|||Belongs to the DEAD box helicase family. DDX3/DED1 subfamily.|||Cytoplasm|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AFL208C ^@ http://purl.uniprot.org/uniprot/Q755M2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/284811:AGOS_ADL047W ^@ http://purl.uniprot.org/uniprot/Q75AG5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC26 family.|||Cytoplasm|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR112C ^@ http://purl.uniprot.org/uniprot/Q74ZT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad17/RAD24 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL257W ^@ http://purl.uniprot.org/uniprot/Q758L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GDT1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL016C ^@ http://purl.uniprot.org/uniprot/Q750G9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/284811:AGOS_AEL328W ^@ http://purl.uniprot.org/uniprot/Q758T0 ^@ Similarity ^@ Belongs to the COG4 family. http://togogenome.org/gene/284811:AGOS_ADR346W ^@ http://purl.uniprot.org/uniprot/Q759D1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with nucleolar and cytoplasmic pre-60S particles. At the end of biogenesis it dissociates from cytoplasmic pre-60S particles and is likely to be exchanged for its ribosomal homolog, RPL24.|||Belongs to the eukaryotic ribosomal protein eL24 family.|||Cytoplasm|||Involved in the biogenesis of the 60S ribosomal subunit. Ensures the docking of NOG1 to pre-60S particles. Activates and recruits ATPase AFG2 to cytoplasmic pre-60S ribosomal particles.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR196W ^@ http://purl.uniprot.org/uniprot/Q759S7 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Erg6/SMT family.|||Catalyzes the methyl transfer from S-adenosyl-methionine to the C-24 of zymosterol to form fecosterol. http://togogenome.org/gene/284811:AGOS_AFR483C ^@ http://purl.uniprot.org/uniprot/Q752U0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 63 family.|||Cleaves the distal alpha 1,2-linked glucose residue from the Glc(3)Man(9)GlcNAc(2) oligosaccharide precursor.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AFR744W ^@ http://purl.uniprot.org/uniprot/Q751T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome composed of at least 40 protein subunits and snoRNA U3. Interacts with snoRNA U3. Interacts with MPP10, KRI1 and with ribosomal proteins RPS1A, RPS4A, RPS4B, RPS8A, RPS8B, RPS11A, RPS11B, RPS13, RPS24, RPS25, RPL4A, RPL7B, RPL8, RPL23, RPL25 and RPL28.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. Essential for vegetative growth.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL191C ^@ http://purl.uniprot.org/uniprot/Q75CV7 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/284811:AGOS_AFL193W ^@ http://purl.uniprot.org/uniprot/Q755Q0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INP2 family.|||Peroxisome membrane|||Required for peroxisome inheritance. http://togogenome.org/gene/284811:AGOS_AEL177C ^@ http://purl.uniprot.org/uniprot/Q758C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM54 family.|||Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).|||Essential component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. The TIM22 complex forms a twin-pore translocase that uses the membrane potential as external driving force (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACL112C ^@ http://purl.uniprot.org/uniprot/Q75CN1 ^@ Domain|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DENR family.|||Cytoplasm|||Interacts with the 40S ribosomal subunit.|||The SUI1 domain may be involved in RNA binding. http://togogenome.org/gene/284811:AGOS_AGR085W ^@ http://purl.uniprot.org/uniprot/Q74ZX3 ^@ Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. Alanine aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/284811:AGOS_ABL183W ^@ http://purl.uniprot.org/uniprot/Q75E53 ^@ Similarity ^@ Belongs to the AAA ATPase family. RarA/MGS1/WRNIP1 subfamily. http://togogenome.org/gene/284811:AGOS_AFR182C ^@ http://purl.uniprot.org/uniprot/Q753Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL253C ^@ http://purl.uniprot.org/uniprot/Q75B30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR204C ^@ http://purl.uniprot.org/uniprot/Q75D18 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/284811:AGOS_ADR115W ^@ http://purl.uniprot.org/uniprot/Q75A09 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. UbiG/COQ3 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane|||O-methyltransferase that catalyzes the 2 O-methylation steps in the ubiquinone biosynthetic pathway. http://togogenome.org/gene/284811:AGOS_ACR256C ^@ http://purl.uniprot.org/uniprot/Q75BL5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/284811:AGOS_ABL037C ^@ http://purl.uniprot.org/uniprot/Q75DQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEG1 family.|||Cell membrane|||Component of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains termed MCCs on the plasma membrane.|||Important for the stabilization of eisosomes, large cytoplasmic protein assemblies that localize to specialized domains on the plasma membrane to cluster specific proteins at sites of membrane invaginations. http://togogenome.org/gene/284811:AGOS_AEL088C ^@ http://purl.uniprot.org/uniprot/Q757V0 ^@ Function|||Similarity ^@ Belongs to the inositol monophosphatase superfamily.|||Converts adenosine 3'-phosphate 5'-phosphosulfate (PAPS) to adenosine 5'-phosphosulfate (APS) and 3'(2')-phosphoadenosine 5'- phosphate (PAP) to AMP. http://togogenome.org/gene/284811:AGOS_AGL162C ^@ http://purl.uniprot.org/uniprot/Q750V1 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284811:AGOS_AER318C ^@ http://purl.uniprot.org/uniprot/Q756E7 ^@ Function|||Subcellular Location Annotation ^@ Functions as component of the transcription regulatory histone acetylation (HAT) complexes SAGA, SALSA and ADA. SAGA is involved in RNA polymerase II-dependent transcriptional regulation.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL019W ^@ http://purl.uniprot.org/uniprot/Q750H2 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/284811:AGOS_AGR394W ^@ http://purl.uniprot.org/uniprot/Q74Z13 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Component of the PEX1-PEX6 AAA ATPase complex, a protein dislocase complex that mediates the ATP-dependent extraction of the PEX5 receptor from peroxisomal membranes, an essential step for PEX5 recycling. Specifically recognizes PEX5 monoubiquitinated at 'Cys-6', and pulls it out of the peroxisome lumen through the PEX2-PEX10-PEX12 retrotranslocation channel. Extraction by the PEX1-PEX6 AAA ATPase complex is accompanied by unfolding of the TPR repeats and release of bound cargo from PEX5.|||Interacts with PEX1; forming the PEX1-PEX6 AAA ATPase complex, which is composed of a heterohexamer formed by a trimer of PEX1-PEX6 dimers.|||Peroxisome membrane|||cytosol http://togogenome.org/gene/284811:AGOS_AFL007C ^@ http://purl.uniprot.org/uniprot/Q754S8 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/284811:AGOS_AER043C ^@ http://purl.uniprot.org/uniprot/Q757H0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_ADL214C ^@ http://purl.uniprot.org/uniprot/Q75AY4 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/284811:AGOS_AAR106C ^@ http://purl.uniprot.org/uniprot/Q75EH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AFR279C ^@ http://purl.uniprot.org/uniprot/Q753N3 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/284811:AGOS_AER138C ^@ http://purl.uniprot.org/uniprot/Q756X6 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).|||Forms a stable heterodimer with SPT16. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).|||In contrast to the orthologous protein in animals and plants, this protein does not contain a HMG box DNA-binding domain. This function may instead be provided by the HMG box of the associated NHP6 protein in the FACT complex of fungi.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL054C ^@ http://purl.uniprot.org/uniprot/Q75DT0 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/284811:AGOS_AEL282W ^@ http://purl.uniprot.org/uniprot/Q758N7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL290W ^@ http://purl.uniprot.org/uniprot/Q75B62 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/284811:AGOS_ADR194C ^@ http://purl.uniprot.org/uniprot/Q759S9 ^@ Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family. http://togogenome.org/gene/284811:AGOS_AFR062C ^@ http://purl.uniprot.org/uniprot/Q754L0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/284811:AGOS_AGL323C ^@ http://purl.uniprot.org/uniprot/Q751M0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_AER257W ^@ http://purl.uniprot.org/uniprot/Q756J7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/284811:AGOS_AGR251C ^@ http://purl.uniprot.org/uniprot/Q74ZE8 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/284811:AGOS_ABR195C ^@ http://purl.uniprot.org/uniprot/Q75D27 ^@ Subcellular Location Annotation ^@ Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ACL157C ^@ http://purl.uniprot.org/uniprot/Q75CS6 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/284811:AGOS_ADR007C ^@ http://purl.uniprot.org/uniprot/Q75AB1 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/284811:AGOS_AAR084W ^@ http://purl.uniprot.org/uniprot/Q75EJ5 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR237C ^@ http://purl.uniprot.org/uniprot/Q759N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. RKM1 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase. http://togogenome.org/gene/284811:AGOS_ACR167C ^@ http://purl.uniprot.org/uniprot/Q75BV4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AlaDH/PNT family.|||Catalyzes the NAD(+)-dependent cleavage of saccharopine to L-lysine and 2-oxoglutarate, the final step in the alpha-aminoadipate (AAA) pathway for lysin biosynthesis.|||Monomer.|||Peroxisome http://togogenome.org/gene/284811:AGOS_AGL276W ^@ http://purl.uniprot.org/uniprot/Q751I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AAR004C ^@ http://purl.uniprot.org/uniprot/Q75ES5 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/284811:AGOS_ABR035C ^@ http://purl.uniprot.org/uniprot/Q75DI9 ^@ Similarity ^@ Belongs to the CWC22 family. http://togogenome.org/gene/284811:AGOS_AFR434W ^@ http://purl.uniprot.org/uniprot/Q752Y7 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/284811:AGOS_AAR129C ^@ http://purl.uniprot.org/uniprot/Q75EF2 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/284811:AGOS_ADR002W ^@ http://purl.uniprot.org/uniprot/Q75AB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP16 family.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAR017W ^@ http://purl.uniprot.org/uniprot/Q75ER2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/284811:AGOS_AFR313C ^@ http://purl.uniprot.org/uniprot/Q753J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AAR181W ^@ http://purl.uniprot.org/uniprot/Q75ED5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/284811:AGOS_AGR073C ^@ http://purl.uniprot.org/uniprot/Q74ZY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. This subunit may anchor the endonuclease complex to the nuclear membrane. Probably carries the active site for 5'-splice site cleavage (By similarity).|||Heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN54 (By similarity). http://togogenome.org/gene/284811:AGOS_ABR169W ^@ http://purl.uniprot.org/uniprot/Q75D54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/284811:AGOS_AEL084W ^@ http://purl.uniprot.org/uniprot/Q757U6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL092C ^@ http://purl.uniprot.org/uniprot/Q755B7 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/284811:AGOS_AFR198W ^@ http://purl.uniprot.org/uniprot/Q753X4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion.|||Cleaves proteins, imported into the mitochondrion, to their mature size. While most mitochondrial precursor proteins are processed to the mature form in one step by mitochondrial processing peptidase (MPP), the sequential cleavage by MIP of an octapeptide after initial processing by MPP is a required step for a subgroup of nuclear-encoded precursor proteins destined for the matrix or the inner membrane (By similarity).|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_ACR086C ^@ http://purl.uniprot.org/uniprot/Q75C31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR142W ^@ http://purl.uniprot.org/uniprot/Q759Y1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AEP1 family.|||Mitochondrion|||Required for translation of the mitochondrial OLI1 transcript encoding subunit 9 of mitochondrial ATP synthase. http://togogenome.org/gene/284811:AGOS_AGL206C ^@ http://purl.uniprot.org/uniprot/Q750Z3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL281C ^@ http://purl.uniprot.org/uniprot/Q75BG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family. PIGB subfamily.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the third mannose to Man2-GlcN-acyl-PI during GPI precursor assembly (By similarity). http://togogenome.org/gene/284811:AGOS_AGR346C ^@ http://purl.uniprot.org/uniprot/Q74Z60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with TAN1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR392C ^@ http://purl.uniprot.org/uniprot/Q753C4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SPP2 family.|||Involved in spliceosome maturation and the first step of pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR432W ^@ http://purl.uniprot.org/uniprot/Q752Y9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL144C ^@ http://purl.uniprot.org/uniprot/Q75E17 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/284811:AGOS_ABL125W ^@ http://purl.uniprot.org/uniprot/Q75DZ8 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_ACR041W ^@ http://purl.uniprot.org/uniprot/Q75C75 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AFR447C ^@ http://purl.uniprot.org/uniprot/Q752X6 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR342C ^@ http://purl.uniprot.org/uniprot/Q759D5 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/284811:AGOS_AEL029W ^@ http://purl.uniprot.org/uniprot/Q757P1 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_AER149W ^@ http://purl.uniprot.org/uniprot/Q756V2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/284811:AGOS_AGR115C ^@ http://purl.uniprot.org/uniprot/Q74ZT3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/284811:AGOS_ABR136W ^@ http://purl.uniprot.org/uniprot/Q75D88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Catalytic component of the COMPASS (Set1C) complex that specifically mono-, di- and trimethylates histone H3 to form H3K4me1/2/3, which subsequently plays a role in telomere length maintenance and transcription elongation regulation.|||Chromosome|||Component of the COMPASS (Set1C) complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL037W ^@ http://purl.uniprot.org/uniprot/Q75AF5 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Involved in vesicular transport between an endosomal compartment and the Golgi apparatus.|||The GRIP domain may serve as a Golgi targeting domain. http://togogenome.org/gene/284811:AGOS_AGR380C ^@ http://purl.uniprot.org/uniprot/Q74Z26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 5 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL126W ^@ http://purl.uniprot.org/uniprot/Q75DZ9 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/284811:AGOS_AEL121W ^@ http://purl.uniprot.org/uniprot/Q757Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABL152W ^@ http://purl.uniprot.org/uniprot/Q75E22 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284811:AGOS_AFR726W ^@ http://purl.uniprot.org/uniprot/Q751U9 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/284811:AGOS_ADL154C ^@ http://purl.uniprot.org/uniprot/Q75AS4 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/284811:AGOS_AFL214C ^@ http://purl.uniprot.org/uniprot/Q755M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL185W ^@ http://purl.uniprot.org/uniprot/Q755Q5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Heterooctamer of 4 alpha and 4 beta chains.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284811:AGOS_ABL115W ^@ http://purl.uniprot.org/uniprot/Q75DY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER436C ^@ http://purl.uniprot.org/uniprot/Q755T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRG8 family.|||Bud|||Bud neck|||Bud tip|||Cytoplasm|||Involved in maintenance of polarized growth and daughter-cell-specific transcription. http://togogenome.org/gene/284811:AGOS_AFL184W ^@ http://purl.uniprot.org/uniprot/Q755Q4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INP1 family.|||Peroxisome membrane|||Required for peroxisome inheritance. http://togogenome.org/gene/284811:AGOS_AFR326W ^@ http://purl.uniprot.org/uniprot/Q753I6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR055C ^@ http://purl.uniprot.org/uniprot/Q75DH1 ^@ Similarity ^@ Belongs to the EFG1/PHD1/stuA family. http://togogenome.org/gene/284811:AGOS_ADL030C ^@ http://purl.uniprot.org/uniprot/Q75AE7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||Phosphorylation at Ser-174 and Ser-175 promotes nuclear export.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER308C ^@ http://purl.uniprot.org/uniprot/Q756F8 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/284811:AGOS_AFR255W ^@ http://purl.uniprot.org/uniprot/Q753S1 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/284811:AGOS_AER394W ^@ http://purl.uniprot.org/uniprot/Q755X4 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFL154C ^@ http://purl.uniprot.org/uniprot/Q755H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35B subfamily.|||Endoplasmic reticulum membrane|||May be involved in specific transport of UDP-Gal from the cytosol to the Golgi lumen. Involved in the maintenance of optimal conditions for the folding of secretory pathway proteins in the endoplasmic reticulum (By similarity). http://togogenome.org/gene/284811:AGOS_AAL075W ^@ http://purl.uniprot.org/uniprot/Q75F03 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADL189W ^@ http://purl.uniprot.org/uniprot/Q75AV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABL012C ^@ http://purl.uniprot.org/uniprot/Q75DM9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS11 family.|||Component of the homotypic vacuole fusion and vacuole protein sorting (HOPS) complex. Component of the class C core vacuole/endosome tethering (CORVET) complex.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGR253W ^@ http://purl.uniprot.org/uniprot/Q74ZE6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284811:AGOS_ABL186W ^@ http://purl.uniprot.org/uniprot/Q75E56 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway and in the salvage pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). http://togogenome.org/gene/284811:AGOS_AAL027W ^@ http://purl.uniprot.org/uniprot/Q75F84 ^@ Similarity ^@ Belongs to the lysophospholipase family. http://togogenome.org/gene/284811:AGOS_ABL148C ^@ http://purl.uniprot.org/uniprot/Q75E80 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex, whose core is composed of TIM22 and TIM54, associated with the 70 kDa heterohexamer composed of TIM9 and TIM10 (or TIM8 and TIM13).|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABL109W ^@ http://purl.uniprot.org/uniprot/Q75DY2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the flavokinase family.|||Catalyzes the phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN) coenzyme.|||Zinc or magnesium. http://togogenome.org/gene/284811:AGOS_ADR190W ^@ http://purl.uniprot.org/uniprot/Q759T3 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the kynurenine formamidase family.|||Catalyzes the hydrolysis of N-formyl-L-kynurenine to L-kynurenine, the second step in the kynurenine pathway of tryptophan degradation. Kynurenine may be further oxidized to nicotinic acid, NAD(H) and NADP(H). Required for elimination of toxic metabolites.|||Homodimer.|||The main chain amide nitrogen atoms of the second glycine and its adjacent residue in the HGGXW motif define the oxyanion hole, and stabilize the oxyanion that forms during the nucleophilic attack by the catalytic serine during substrate cleavage. http://togogenome.org/gene/284811:AGOS_ADL306C ^@ http://purl.uniprot.org/uniprot/Q75B78 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||Cytoplasm|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with DRE2; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Mitochondrion|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of DRE2, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. Positively controls H(2)O(2)-induced cell death. http://togogenome.org/gene/284811:AGOS_ACL199C ^@ http://purl.uniprot.org/uniprot/Q75CW5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family. UQCRC2/QCR2 subfamily.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Does not seem to have protease activity as it lacks the zinc-binding site.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR262C ^@ http://purl.uniprot.org/uniprot/Q759L4 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AGL333W ^@ http://purl.uniprot.org/uniprot/Q751N0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dynein light intermediate chain DYN3 family.|||Component of the cytoplasmic dynein which acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle (By similarity).|||The cytoplasmic dynein is composed of at least two heavy chains and a number of intermediate and light chains.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AEL009C ^@ http://purl.uniprot.org/uniprot/Q757M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 2 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL125C ^@ http://purl.uniprot.org/uniprot/Q757Y5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER019C ^@ http://purl.uniprot.org/uniprot/Q757J4 ^@ Similarity ^@ Belongs to the MDM20/NAA25 family. http://togogenome.org/gene/284811:AGOS_AFL232W ^@ http://purl.uniprot.org/uniprot/Q755P5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/284811:AGOS_AAL020C ^@ http://purl.uniprot.org/uniprot/Q75ET6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial ribosomal protein bL27 family.|||Component of the large subunit of mitochondrial ribosome.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AEL235W ^@ http://purl.uniprot.org/uniprot/Q758J7 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/284811:AGOS_AFL044W ^@ http://purl.uniprot.org/uniprot/Q754W1 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/284811:AGOS_ADR322W ^@ http://purl.uniprot.org/uniprot/Q759F4 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/284811:AGOS_ACL034W ^@ http://purl.uniprot.org/uniprot/Q75CF4 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AFL161C ^@ http://purl.uniprot.org/uniprot/Q755I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GYP5 family.|||Cytoplasm|||GTPase-activating protein which accelerates the GTP hydrolysis rate of several GTPases. Involved in ER to Golgi trafficking and polarized exocytosis (By similarity). http://togogenome.org/gene/284811:AGOS_AFR421C ^@ http://purl.uniprot.org/uniprot/Q753A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YAE1 family.|||Cytoplasm|||May form a complex with LTO1.|||Nucleus|||The complex LTO1:YAE1 may function as a target specific adapter that probably recruits apo-RPLI1 to the cytosolic iron-sulfur protein assembly (CIA) complex machinery. May be required for biogenesis of the large ribosomal subunit and initiation of translation. http://togogenome.org/gene/284811:AGOS_AGR350C ^@ http://purl.uniprot.org/uniprot/Q74Z56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. Yeast FIT2A/YFT2 subfamily.|||Endoplasmic reticulum membrane|||Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization). Involved in phospholipid biosynthesis.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR177C ^@ http://purl.uniprot.org/uniprot/Q75D46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Nucleus|||Serine/threonine-protein kinase involved in transcription regulation. Phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase (By similarity). http://togogenome.org/gene/284811:AGOS_ABR010C ^@ http://purl.uniprot.org/uniprot/Q75DL1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/284811:AGOS_ADR384W ^@ http://purl.uniprot.org/uniprot/Q758Z3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AFL088W ^@ http://purl.uniprot.org/uniprot/Q755B3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR241W ^@ http://purl.uniprot.org/uniprot/Q753T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/284811:AGOS_AGR294C ^@ http://purl.uniprot.org/uniprot/Q74ZA9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Ran family.|||Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR295W ^@ http://purl.uniprot.org/uniprot/Q753L7 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AFR262C ^@ http://purl.uniprot.org/uniprot/Q753R4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL105C ^@ http://purl.uniprot.org/uniprot/Q75CM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SBE2 family.|||Golgi apparatus|||With SBE22, is involved in cell wall integrity and polarity processes like bud growth. http://togogenome.org/gene/284811:AGOS_ADR085W ^@ http://purl.uniprot.org/uniprot/Q75AH4 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/284811:AGOS_ADR103C ^@ http://purl.uniprot.org/uniprot/Q75AH3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL41 family. http://togogenome.org/gene/284811:AGOS_ACR211W ^@ http://purl.uniprot.org/uniprot/Q75BR0 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/284811:AGOS_AER380C ^@ http://purl.uniprot.org/uniprot/Q755Y7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AER113W ^@ http://purl.uniprot.org/uniprot/Q757A0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL215W ^@ http://purl.uniprot.org/uniprot/Q75AY5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/284811:AGOS_ACR143W ^@ http://purl.uniprot.org/uniprot/Q75BX8 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_ADR345C ^@ http://purl.uniprot.org/uniprot/Q759D2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM14 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to stimulate activity of mtHSP70 (SSC1) (By similarity).|||Heterodimer with PAM16. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).|||Mitochondrion inner membrane|||The J domain is essential for co-chaperone activity and mediates the heterodimerization with the J-like domain of PAM16. http://togogenome.org/gene/284811:AGOS_AGR349W ^@ http://purl.uniprot.org/uniprot/Q74Z57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-O/MCM21 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR063C ^@ http://purl.uniprot.org/uniprot/Q75C54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADL197C ^@ http://purl.uniprot.org/uniprot/Q75AW7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family. PFA3 subfamily.|||Palmitoyltransferase specific for VAC8. Palmitoylates VAC8 at one or more of its N-terminal cysteine residues, which is required for its proper membrane localization (By similarity).|||The DHHC domain is required for palmitoyltransferase activity.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFR485C ^@ http://purl.uniprot.org/uniprot/Q752T8 ^@ Similarity ^@ In the C-terminal section; belongs to the TrpB family.|||In the N-terminal section; belongs to the TrpA family. http://togogenome.org/gene/284811:AGOS_ABR153C ^@ http://purl.uniprot.org/uniprot/Q75D70 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/284811:AGOS_ABL119C ^@ http://purl.uniprot.org/uniprot/Q75DZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AEP2 family.|||Binds to the 5'UTR of the OLI1 mRNA.|||Mitochondrion|||Required for translation of the mitochondrial OLI1 transcript coding for the mitochondrial ATP synthase subunit 9. http://togogenome.org/gene/284811:AGOS_AFR605C ^@ http://purl.uniprot.org/uniprot/Q752H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER154C ^@ http://purl.uniprot.org/uniprot/Q756U8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/284811:AGOS_AEL238C ^@ http://purl.uniprot.org/uniprot/Q758K0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FPP/GGPP synthase family.|||Binds 2 Mg(2+) ions per subunit.|||Catalyzes the trans-addition of the 3 molecules of IPP onto DMAPP to form geranylgeranyl pyrophosphate. May be involved in vesicle trafficking and protein sorting (By similarity).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL141W ^@ http://purl.uniprot.org/uniprot/Q75AR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR212C ^@ http://purl.uniprot.org/uniprot/Q759R1 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/284811:AGOS_ABL132W ^@ http://purl.uniprot.org/uniprot/Q75E05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR106C ^@ http://purl.uniprot.org/uniprot/Q754G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic60 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Plays a role in keeping cristae membranes connected to the inner boundary membrane. Also promotes protein import via the mitochondrial intermembrane space assembly (MIA) pathway (By similarity).|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL268W ^@ http://purl.uniprot.org/uniprot/Q758V2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/284811:AGOS_ABL189W ^@ http://purl.uniprot.org/uniprot/Q75E59 ^@ Similarity ^@ Belongs to the AIM6 family. http://togogenome.org/gene/284811:AGOS_AFR468W ^@ http://purl.uniprot.org/uniprot/Q752V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat NOL10/ENP2 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR127C ^@ http://purl.uniprot.org/uniprot/Q74ZS1 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284811:AGOS_AER297C ^@ http://purl.uniprot.org/uniprot/Q756G9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. GCN5 subfamily.|||Histone acetyltransferase that acetylates histone H2B to form H2BK11ac and H2BK16ac, histone H3 to form H3K14ac, with a lower preference histone H4 to form H4K8ac and H4K16ac, and contributes to H2A.Z acetylation (By similarity). Acetylation of histones gives a specific tag for epigenetic transcription activation (By similarity). In addition to histone acetyltransferase, can use different acyl-CoA substrates, such as (2E)-butenoyl-CoA (crotonyl-CoA) and is able to mediate histone crotonylation (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL082W ^@ http://purl.uniprot.org/uniprot/Q757U4 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AFR546W ^@ http://purl.uniprot.org/uniprot/Q752M8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR347C ^@ http://purl.uniprot.org/uniprot/Q753G5 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/284811:AGOS_ABL002C ^@ http://purl.uniprot.org/uniprot/Q75DL9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/284811:AGOS_AEL171C ^@ http://purl.uniprot.org/uniprot/Q758C3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the battenin family.|||Involved in vacuolar transport and vacuole pH homeostasis. Also required for cytokinesis (By similarity).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AEL124W ^@ http://purl.uniprot.org/uniprot/Q757Y4 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/284811:AGOS_ADR255W ^@ http://purl.uniprot.org/uniprot/Q759M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIP5 family.|||Cytoplasm|||May negatively regulate the SNF1 kinase. http://togogenome.org/gene/284811:AGOS_AFR194W ^@ http://purl.uniprot.org/uniprot/Q753X8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/284811:AGOS_AER051C ^@ http://purl.uniprot.org/uniprot/Q757G2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AFR016W ^@ http://purl.uniprot.org/uniprot/Q754Q6 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/284811:AGOS_AFR272W ^@ http://purl.uniprot.org/uniprot/Q753P0 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/284811:AGOS_AEL017W ^@ http://purl.uniprot.org/uniprot/Q757L7 ^@ Similarity ^@ Belongs to the SH3YL1 family. http://togogenome.org/gene/284811:AGOS_AER238C ^@ http://purl.uniprot.org/uniprot/Q756L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_ABL031W ^@ http://purl.uniprot.org/uniprot/Q75DP8 ^@ Function|||Similarity ^@ Belongs to the MTC2 family.|||May be involved in telomere capping. http://togogenome.org/gene/284811:AGOS_AEL156W ^@ http://purl.uniprot.org/uniprot/Q758A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the esterase D family.|||Cytoplasm|||Serine hydrolase involved in the detoxification of formaldehyde. http://togogenome.org/gene/284811:AGOS_AGR383W ^@ http://purl.uniprot.org/uniprot/Q74Z23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL295W ^@ http://purl.uniprot.org/uniprot/Q75B67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR358W ^@ http://purl.uniprot.org/uniprot/Q74Z48 ^@ Similarity ^@ In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/284811:AGOS_AAL143W ^@ http://purl.uniprot.org/uniprot/Q75F71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).|||Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity). http://togogenome.org/gene/284811:AGOS_AGR340W ^@ http://purl.uniprot.org/uniprot/Q74Z66 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/284811:AGOS_AGR198C ^@ http://purl.uniprot.org/uniprot/Q74ZK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL222W ^@ http://purl.uniprot.org/uniprot/Q751C8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/284811:AGOS_ADR189W ^@ http://purl.uniprot.org/uniprot/Q759T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit G family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. This subunit can bind 18S rRNA. http://togogenome.org/gene/284811:AGOS_ACR139C ^@ http://purl.uniprot.org/uniprot/Q75BY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). http://togogenome.org/gene/284811:AGOS_ABL120W ^@ http://purl.uniprot.org/uniprot/Q75DZ3 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/284811:AGOS_ADR218W ^@ http://purl.uniprot.org/uniprot/Q759Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||Nucleus|||Plays a central role in chromosome cohesion during cell division by preventing premature dissociation of cohesin complex from centromeres after prophase, when most of cohesin complex dissociates from chromosomes arms. May act by protecting RAD21 and or REC8 from cleavage by ESP1/separase (By similarity).|||centromere http://togogenome.org/gene/284811:AGOS_ABL079C ^@ http://purl.uniprot.org/uniprot/Q75DV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IML1 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ACR199C ^@ http://purl.uniprot.org/uniprot/Q75BS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC13 family.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. It also functions as a component of the nuclear pore complex (NPC). NPC components, collectively referred to as nucleoporins (NUPs), can play the role of both NPC structural components and of docking or interaction partners for transiently associated nuclear transport factors. SEC13 is required for efficient mRNA export from the nucleus to the cytoplasm and for correct nuclear pore biogenesis and distribution (By similarity).|||Endoplasmic reticulum membrane|||The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Component of the nuclear pore complex (NPC). NPC constitutes the exclusive means of nucleocytoplasmic transport. NPCs allow the passive diffusion of ions and small molecules and the active, nuclear transport receptor-mediated bidirectional transport of macromolecules such as proteins, RNAs, ribonucleoparticles (RNPs), and ribosomal subunits across the nuclear envelope. Due to its 8-fold rotational symmetry, all subunits are present with 8 copies or multiples thereof.|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_ADR064C ^@ http://purl.uniprot.org/uniprot/Q75A55 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/284811:AGOS_AAL037C ^@ http://purl.uniprot.org/uniprot/Q75EW5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IPK1 type 1 family.|||Has kinase activity and phosphorylates inositol-1,3,4,5,6-pentakisphosphate (Ins(1,3,4,5,6)P5) to produce 1,2,3,4,5,6-hexakisphosphate (InsP6), also known as phytate.|||Nucleus|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/284811:AGOS_AEL026C ^@ http://purl.uniprot.org/uniprot/Q757N8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/284811:AGOS_ADR111W ^@ http://purl.uniprot.org/uniprot/Q75A16 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/284811:AGOS_AGL355W ^@ http://purl.uniprot.org/uniprot/Q751P4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC22 family.|||Cytoplasm|||May be involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL021W ^@ http://purl.uniprot.org/uniprot/Q75AD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_AFR567W ^@ http://purl.uniprot.org/uniprot/Q752K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL171W ^@ http://purl.uniprot.org/uniprot/Q75AU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR216W ^@ http://purl.uniprot.org/uniprot/Q759Q7 ^@ Similarity ^@ Belongs to the nucleoporin Nup133 family. http://togogenome.org/gene/284811:AGOS_AER102W ^@ http://purl.uniprot.org/uniprot/Q757B1 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/284811:AGOS_AGL137W ^@ http://purl.uniprot.org/uniprot/Q750S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Forms part of complex II containing four subunits: a flavoprotein (FP), an iron-sulfur protein (IP) and a cytochrome b composed of a large and a small subunit.|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR080W ^@ http://purl.uniprot.org/uniprot/Q74ZX8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/284811:AGOS_ABR230C ^@ http://purl.uniprot.org/uniprot/Q75CZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL086W ^@ http://purl.uniprot.org/uniprot/Q757U8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL037W ^@ http://purl.uniprot.org/uniprot/Q75CF6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. The coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284811:AGOS_ADR294C ^@ http://purl.uniprot.org/uniprot/Q759H0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YSP2 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL121W ^@ http://purl.uniprot.org/uniprot/Q75AP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AER114W ^@ http://purl.uniprot.org/uniprot/Q756Z9 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/284811:AGOS_AAL089W ^@ http://purl.uniprot.org/uniprot/Q75F17 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_ABR130W ^@ http://purl.uniprot.org/uniprot/Q75D94 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX23 family.|||Mitochondrion intermembrane space|||Required for the assembly of cytochrome c oxidase. http://togogenome.org/gene/284811:AGOS_ADR080W ^@ http://purl.uniprot.org/uniprot/Q75A39 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGR320W ^@ http://purl.uniprot.org/uniprot/Q74ZF8 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/284811:AGOS_ADL277W ^@ http://purl.uniprot.org/uniprot/Q75B54 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/284811:AGOS_AFL172W ^@ http://purl.uniprot.org/uniprot/Q755J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BBP1 family.|||Component of the spindle pole body (SPB) required for insertion of the nascent SPB into the nuclear envelope and for the proper execution of spindle pole body (SPB) duplication. Connects the central plaque of the SPB with the half-bridge. Required for proper localization of CDC5 at the SPB and for proper M-phase progression (By similarity).|||Homodimer.|||spindle pole body http://togogenome.org/gene/284811:AGOS_ABL204W ^@ http://purl.uniprot.org/uniprot/Q75E86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Cytoplasm|||Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity.|||Homohexamer. Binds to nucleic acids. Binds single-stranded DNA and RNA with higher affinity than double-stranded DNA.|||Mitochondrion|||The normal physiological role of the enzyme is unknown, but it is not essential for the viability of yeast cells. Has aminopeptidase activity, shortening substrate peptides sequentially by 1 amino acid. Has bleomycin hydrolase activity, which can protect the cell from the toxic effects of bleomycin. Has homocysteine-thiolactonase activity, protecting the cell against homocysteine toxicity. Acts as a repressor in the GAL4 regulatory system, but this does not require either the peptidase or nucleic acid-binding activities. http://togogenome.org/gene/284811:AGOS_AFR391W ^@ http://purl.uniprot.org/uniprot/Q753C5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM31/MDM32 family.|||Involved in the organization of the mitochondrial membranes and the global structure of the mitochondria. Also required for mitochondrial distribution and mobility as well as for the maintenance of mitochondrial DNA nucleoids structures (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR194W ^@ http://purl.uniprot.org/uniprot/Q74ZK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR182C ^@ http://purl.uniprot.org/uniprot/Q74ZL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL072C ^@ http://purl.uniprot.org/uniprot/Q75F00 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/284811:AGOS_ACR160C ^@ http://purl.uniprot.org/uniprot/Q75BW1 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/284811:AGOS_ACR239C ^@ http://purl.uniprot.org/uniprot/Q75BN2 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/284811:AGOS_ACR061C ^@ http://purl.uniprot.org/uniprot/Q75C55 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/284811:AGOS_AAR037W ^@ http://purl.uniprot.org/uniprot/Q75EP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR316C ^@ http://purl.uniprot.org/uniprot/Q74Z87 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AER334C ^@ http://purl.uniprot.org/uniprot/Q756D3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-Z subfamily.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFL075W ^@ http://purl.uniprot.org/uniprot/Q755A0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDC1 family.|||Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.|||Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR042W ^@ http://purl.uniprot.org/uniprot/Q750B5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX4 family.|||Forms a heterodimer with SLX1.|||Nucleus|||Phosphorylated in response to DNA damage.|||Regulatory subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA (By similarity). http://togogenome.org/gene/284811:AGOS_AFR156W ^@ http://purl.uniprot.org/uniprot/Q754B4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAR156C ^@ http://purl.uniprot.org/uniprot/Q75EB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family.|||Catalyzes the covalent attachment of ubiquitin to other proteins. Plays a role in transcription regulation by catalyzing the monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation. Also involved in postreplication repair of UV-damaged DNA, in N-end rule-dependent protein degradation and in sporulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR169W ^@ http://purl.uniprot.org/uniprot/Q754A3 ^@ Similarity ^@ Belongs to the GCN1 family. http://togogenome.org/gene/284811:AGOS_AFL085C ^@ http://purl.uniprot.org/uniprot/Q755B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL162C ^@ http://purl.uniprot.org/uniprot/Q75E32 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Core regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).|||Nucleus|||Regulatory subunit 3 (R3) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4. http://togogenome.org/gene/284811:AGOS_AGL069C ^@ http://purl.uniprot.org/uniprot/Q750M5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR239W ^@ http://purl.uniprot.org/uniprot/Q753T7 ^@ Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family. http://togogenome.org/gene/284811:AGOS_AMI004W ^@ http://purl.uniprot.org/uniprot/Q75G41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS3 family.|||Essential for mitochondrial protein synthesis and required for the maturation of small ribosomal subunits.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL001W ^@ http://purl.uniprot.org/uniprot/Q750F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic component of the histone acetylase B (HAT-B) complex. Acetylates 'Lys-12' of histone H4 which is required for telomeric silencing. Has intrinsic substrate specificity that modifies lysine in recognition sequence GXGKXG. Involved in DNA double-strand break repair.|||Component of the HAT-B complex composed of at least HAT1 and HAT2. The HAT-B complex binds to histone H4 tail (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL022W ^@ http://purl.uniprot.org/uniprot/Q754U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||actin patch http://togogenome.org/gene/284811:AGOS_AFL202C ^@ http://purl.uniprot.org/uniprot/Q755L6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL186C ^@ http://purl.uniprot.org/uniprot/Q750X5 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/284811:AGOS_AFR171W ^@ http://purl.uniprot.org/uniprot/Q754A1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL043C ^@ http://purl.uniprot.org/uniprot/Q75EX1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/284811:AGOS_AFR081C ^@ http://purl.uniprot.org/uniprot/Q754J3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERT1/acuK family.|||Nucleus|||Transcription factor which regulates nonfermentable carbon utilization. http://togogenome.org/gene/284811:AGOS_ABL170C ^@ http://purl.uniprot.org/uniprot/Q75E40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ABR109C ^@ http://purl.uniprot.org/uniprot/Q75DB7 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/284811:AGOS_ACR148W ^@ http://purl.uniprot.org/uniprot/Q75BX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM44 family.|||Bud neck http://togogenome.org/gene/284811:AGOS_ADR025W ^@ http://purl.uniprot.org/uniprot/Q75A93 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/284811:AGOS_AEL215C ^@ http://purl.uniprot.org/uniprot/Q758H7 ^@ Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. http://togogenome.org/gene/284811:AGOS_AFR395C ^@ http://purl.uniprot.org/uniprot/Q753C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Alpha-1,2-mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers a fourth mannose to trimannosyl-GPIs during GPI precursor assembly. The presence of a fourth mannose in GPI is essential in fungi (By similarity).|||Belongs to the glycosyltransferase 22 family. PIGZ subfamily.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AGL274W ^@ http://purl.uniprot.org/uniprot/Q751I0 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_AFR352C ^@ http://purl.uniprot.org/uniprot/Q753R1 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/284811:AGOS_AFR252C ^@ http://purl.uniprot.org/uniprot/Q753S4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/284811:AGOS_ADL276W ^@ http://purl.uniprot.org/uniprot/Q75B53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR060W ^@ http://purl.uniprot.org/uniprot/Q75DG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 76 family.|||Cell membrane|||Required for normal synthesis of the cell wall.|||cell wall http://togogenome.org/gene/284811:AGOS_AFR387C ^@ http://purl.uniprot.org/uniprot/Q753C9 ^@ Similarity ^@ Belongs to the thiamine pyrophosphokinase family. http://togogenome.org/gene/284811:AGOS_ABR160C ^@ http://purl.uniprot.org/uniprot/Q75D63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER186C ^@ http://purl.uniprot.org/uniprot/Q756R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HEK2 family.|||Binds RNA.|||Cytoplasm|||Nucleus|||P-body|||RNA-binding protein involved in the correct localization of transcripts in the cell. RNA localization is a widespread mechanism for achieving localized protein synthesis. Involved in structural and functional organization of telomeric chromatin and regulates silencing at the HMR locus (By similarity).|||telomere http://togogenome.org/gene/284811:AGOS_AFL123W ^@ http://purl.uniprot.org/uniprot/Q755E6 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/284811:AGOS_AAL015W ^@ http://purl.uniprot.org/uniprot/Q75EV1 ^@ Similarity ^@ Belongs to the DCC1 family. http://togogenome.org/gene/284811:AGOS_AFR542W ^@ http://purl.uniprot.org/uniprot/Q752N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL304W ^@ http://purl.uniprot.org/uniprot/Q75B76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/284811:AGOS_AFR698C ^@ http://purl.uniprot.org/uniprot/Q751X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR407C ^@ http://purl.uniprot.org/uniprot/Q758X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor potential (TRP) ion channel family.|||Membrane http://togogenome.org/gene/284811:AGOS_ACL097C ^@ http://purl.uniprot.org/uniprot/Q75CL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABL032C ^@ http://purl.uniprot.org/uniprot/Q75DP9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR250C ^@ http://purl.uniprot.org/uniprot/Q759M6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGR183C ^@ http://purl.uniprot.org/uniprot/Q74ZL5 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by GCN5 to form H2BK11ac and H2BK16ac. H2BK16ac can also be formed by ESA1. Acetylation of N-terminal lysines and particularly formation of H2BK11acK16ac has a positive effect on transcription (By similarity).|||Belongs to the histone H2B family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Monoubiquitinated by the UBC2-BRE1 complex to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation. H2BK123ub1 also modulates the formation of double-strand breaks during meiosis and is a prerequisite for DNA-damage checkpoint activation (By similarity).|||Nucleus|||Phosphorylated by STE20 to form H2BS10ph during progression through meiotic prophase. May be correlated with chromosome condensation (By similarity).|||Sumoylation to form H2BK6su and probably also H2BK16su or H2BK17su, occurs preferentially near the telomeres and represses gene transcription.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK6ac = acetylated Lys-7; H2BK6su = sumoylated Lys-7; H2BS10ph = phosphorylated Ser-11; H2BK11ac = acetylated Lys-12; H2BK16ac = acetylated Lys-17; H2BK16su = sumoylated Lys-17; H2BK17su = sumoylated Lys-18; H2BK123ub1 = monoubiquitinated Lys-125. http://togogenome.org/gene/284811:AGOS_AEL273C ^@ http://purl.uniprot.org/uniprot/Q758M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGL318W ^@ http://purl.uniprot.org/uniprot/Q751R1 ^@ Similarity ^@ Belongs to the VPS25 family. http://togogenome.org/gene/284811:AGOS_AEL315W ^@ http://purl.uniprot.org/uniprot/Q758R8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex SPC34 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AEL053C ^@ http://purl.uniprot.org/uniprot/Q757R5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR247W ^@ http://purl.uniprot.org/uniprot/Q75DB2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_ACR215C ^@ http://purl.uniprot.org/uniprot/Q75BQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Cytoplasm|||Homotetramer.|||Interconversion of serine and glycine. http://togogenome.org/gene/284811:AGOS_AER449W ^@ http://purl.uniprot.org/uniprot/Q755R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with mRNPs.|||Belongs to the YRA1 family.|||Involved in export of poly(A) mRNAs from the nucleus. Recruited to the coding sequences as well as poly-A sites of active genes (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR289C ^@ http://purl.uniprot.org/uniprot/Q759I8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR036C ^@ http://purl.uniprot.org/uniprot/Q75C80 ^@ Function|||Similarity ^@ Belongs to the FYV8 family.|||Involved in the resistance to unfolded protein response (UPR)-inducing agents. http://togogenome.org/gene/284811:AGOS_AFL065C ^@ http://purl.uniprot.org/uniprot/Q754Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAD1 family.|||Central component of the spindle assembly checkpoint.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR428C ^@ http://purl.uniprot.org/uniprot/Q753Q6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284811:AGOS_AEL247W ^@ http://purl.uniprot.org/uniprot/Q758K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR363C ^@ http://purl.uniprot.org/uniprot/Q759B4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/284811:AGOS_ACL080W ^@ http://purl.uniprot.org/uniprot/Q75CJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR056W ^@ http://purl.uniprot.org/uniprot/Q75A62 ^@ Similarity ^@ Belongs to the PGA52 family. http://togogenome.org/gene/284811:AGOS_AER190W ^@ http://purl.uniprot.org/uniprot/Q756R4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAR134W ^@ http://purl.uniprot.org/uniprot/Q75EE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/284811:AGOS_AAR018W ^@ http://purl.uniprot.org/uniprot/Q75ER1 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/284811:AGOS_AEL256C ^@ http://purl.uniprot.org/uniprot/Q758L7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR079W ^@ http://purl.uniprot.org/uniprot/Q75C38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0057 (PMP3) family.|||Cell membrane|||Plays a role in the regulation of membrane potential. Could mediate a proton leak (By similarity). http://togogenome.org/gene/284811:AGOS_AFR204W ^@ http://purl.uniprot.org/uniprot/Q753W8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex HSK3 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_ACR136C ^@ http://purl.uniprot.org/uniprot/Q75BY4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/284811:AGOS_ACR044C ^@ http://purl.uniprot.org/uniprot/Q75C72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/284811:AGOS_AGR162C ^@ http://purl.uniprot.org/uniprot/Q74ZN6 ^@ Similarity ^@ Belongs to the XPC family. http://togogenome.org/gene/284811:AGOS_ADR337C ^@ http://purl.uniprot.org/uniprot/Q759E0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER251W ^@ http://purl.uniprot.org/uniprot/Q756K3 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Component of a cullin-RING ligase (CRL)-like complex composed of at least the cullin RTT101, a linker protein MMS1, and the potential substrate receptor ESC2.|||Cytoplasm|||May be a substrate targeting component of a cullin-RING-based E3 ubiquitin-protein ligase complex RTT101(MMS1-ESC2). Involved in HMR and telomere silencing via the recruitment or stabilizing of the SIR (silent information regulators) complex (By similarity).|||Nucleus|||The 2 SUMO-like regions, although related to ubiquitin domains lack the conserved acceptor Gly residue in position 456. http://togogenome.org/gene/284811:AGOS_ABL101C ^@ http://purl.uniprot.org/uniprot/Q75DX4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/284811:AGOS_AGR157C ^@ http://purl.uniprot.org/uniprot/Q74ZP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGR118W ^@ http://purl.uniprot.org/uniprot/Q74ZT0 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/284811:AGOS_ADL134W ^@ http://purl.uniprot.org/uniprot/Q75AQ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Cytoplasmic vesicle membrane|||Involved in mitochondrial or peroxisomal functions and amino acid signaling pathways.|||May contain a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFL171W ^@ http://purl.uniprot.org/uniprot/Q755J4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADR268W ^@ http://purl.uniprot.org/uniprot/Q759K8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWP1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/284811:AGOS_ADL116C ^@ http://purl.uniprot.org/uniprot/Q75AN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AFL060W ^@ http://purl.uniprot.org/uniprot/Q754X6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP1/NBP35 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.|||Cytoplasm|||Heterotetramer of 2 NBP35 and 2 CFD1 chains.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR113W ^@ http://purl.uniprot.org/uniprot/Q75EG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Probably involved in transport through the plasma membrane. http://togogenome.org/gene/284811:AGOS_AFR369W ^@ http://purl.uniprot.org/uniprot/Q753E7 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/284811:AGOS_AFL001W ^@ http://purl.uniprot.org/uniprot/Q754S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that trimethylates elongation factor 1-alpha at 'Lys-79'. http://togogenome.org/gene/284811:AGOS_AEL253W ^@ http://purl.uniprot.org/uniprot/Q758L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL391C ^@ http://purl.uniprot.org/uniprot/Q75BG3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/284811:AGOS_AFL049C ^@ http://purl.uniprot.org/uniprot/Q754W6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGR240W ^@ http://purl.uniprot.org/uniprot/Q74ZG7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_AFR648W ^@ http://purl.uniprot.org/uniprot/Q752C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR356W ^@ http://purl.uniprot.org/uniprot/Q74Z50 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/284811:AGOS_AFR209W ^@ http://purl.uniprot.org/uniprot/Q753W3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A component of the endosomal sorting required for transport complex III (ESCRT-III).|||Belongs to the SNF7 family.|||Cytoplasm|||Endosome membrane|||Required for the sorting and concentration of proteins resulting in the entry of these proteins into the invaginating vesicles of the multivesicular body (MVB). Also required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH (By similarity). http://togogenome.org/gene/284811:AGOS_AAR012C ^@ http://purl.uniprot.org/uniprot/Q75ER7 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_ABR147C ^@ http://purl.uniprot.org/uniprot/Q75D77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPP4R2 family.|||Nucleus|||Regulatory subunit (R2) of the histone H2A phosphatase complex (HTP-C) consisting of PPH3, PSY2 and PSY4.|||Regulatory subunit of the histone H2A phosphatase complex, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity). http://togogenome.org/gene/284811:AGOS_ABL202W ^@ http://purl.uniprot.org/uniprot/Q75E72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL245C ^@ http://purl.uniprot.org/uniprot/Q751F1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NAC-beta family.|||Component of the nascent polypeptide-associated complex (NAC), a dynamic component of the ribosomal exit tunnel, protecting the emerging polypeptides from interaction with other cytoplasmic proteins to ensure appropriate nascent protein targeting. The NAC complex also promotes mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD1 may act as a transcription factor that exert a negative effect on the expression of several genes that are transcribed by RNA polymerase II.|||Cytoplasm|||Nucleus|||Part of the nascent polypeptide-associated complex (NAC), consisting of EGD2 and EGD1. NAC associates with ribosomes via EGD1 (By similarity). http://togogenome.org/gene/284811:AGOS_AFR481W ^@ http://purl.uniprot.org/uniprot/Q752U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CGR1 family.|||Involved in nucleolar integrity and required for processing of the pre-rRNA for the 60S ribosome subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL321W ^@ http://purl.uniprot.org/uniprot/Q751L8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AEL300C ^@ http://purl.uniprot.org/uniprot/Q758Q3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/284811:AGOS_ADR102W ^@ http://purl.uniprot.org/uniprot/Q9UVJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).|||Endomembrane system|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ADL138C ^@ http://purl.uniprot.org/uniprot/Q75AQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the third glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Glc(2)Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG10 glucosyltransferase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ABL117C ^@ http://purl.uniprot.org/uniprot/Q75DZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ADL300W ^@ http://purl.uniprot.org/uniprot/Q75B72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER192W ^@ http://purl.uniprot.org/uniprot/Q756R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL105C ^@ http://purl.uniprot.org/uniprot/Q755C8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Binds 1 zinc ion per subunit.|||Formation of pseudouridine at positions 27 and 28 in the anticodon stem and loop of transfer RNAs; at positions 34 and 36 of intron-containing precursor tRNA(Ile) and at position 35 in the intron-containing tRNA(Tyr). Catalyzes pseudouridylation at position 44 in U2 snRNA. Also catalyzes pseudouridylation of mRNAs.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL087C ^@ http://purl.uniprot.org/uniprot/Q757U9 ^@ Function|||Similarity ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of mitochondrial tRNA(Lys), tRNA(Glu) and tRNA(Gln). Required for the formation of 5-taurinomethyl-2-thiouridine (tm5s2U) of mitochondrial tRNA(Lys), tRNA(Glu), and tRNA(Gln) at the wobble position. ATP is required to activate the C2 atom of the wobble base. http://togogenome.org/gene/284811:AGOS_AER041W ^@ http://purl.uniprot.org/uniprot/Q757H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PITP family.|||Binds phosphatidylinositol (PtdIns).|||Cytoplasm|||Endosome|||Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. May also regulate post-Golgi membrane-trafficking events and have a role resistance to oxidative stress (By similarity). http://togogenome.org/gene/284811:AGOS_AGR372W ^@ http://purl.uniprot.org/uniprot/Q74Z34 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin-conjugating enzyme family.|||Catalyzes the covalent attachment of ubiquitin to other proteins. Functions in degradation of misfolded or regulated proteins localized in the endoplasmic reticulum (ER) lumen or membrane via the ubiquitin-proteasome system. Cognate E2 conjugating enzyme for the DOA10 ubiquitin ligase complex, which is part of the ERAD-C pathway responsible for the rapid degradation of membrane proteins with misfolded cytoplasmic domains.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AFR738C ^@ http://purl.uniprot.org/uniprot/Q751T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACL073W ^@ http://purl.uniprot.org/uniprot/Q75CJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL342C ^@ http://purl.uniprot.org/uniprot/Q751R3 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/284811:AGOS_AEL118C ^@ http://purl.uniprot.org/uniprot/Q757X8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NPR/HAL subfamily. HAL5 sub-subfamily. http://togogenome.org/gene/284811:AGOS_ACL189C ^@ http://purl.uniprot.org/uniprot/Q75CV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL313C ^@ http://purl.uniprot.org/uniprot/Q758R6 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family. http://togogenome.org/gene/284811:AGOS_AGL142C ^@ http://purl.uniprot.org/uniprot/Q750T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAL170W ^@ http://purl.uniprot.org/uniprot/Q75F86 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/284811:AGOS_AFR141C ^@ http://purl.uniprot.org/uniprot/Q754C9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL235W ^@ http://purl.uniprot.org/uniprot/Q755P8 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_ADR254W ^@ http://purl.uniprot.org/uniprot/Q759M2 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/284811:AGOS_AER421W ^@ http://purl.uniprot.org/uniprot/Q755U7 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/284811:AGOS_AAR119W ^@ http://purl.uniprot.org/uniprot/Q75EG2 ^@ Subcellular Location Annotation|||Subunit ^@ Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/284811:AGOS_ADR267W ^@ http://purl.uniprot.org/uniprot/Q759K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the OSW5 family.|||Involved in spore wall assembly.|||Membrane http://togogenome.org/gene/284811:AGOS_AER085C ^@ http://purl.uniprot.org/uniprot/Q757C8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the fungal fatty acid synthetase subunit beta family.|||Fatty acid synthetase catalyzes the formation of long-chain fatty acids from acetyl-CoA, malonyl-CoA and NADPH. The beta subunit contains domains for: [acyl-carrier-protein] acetyltransferase and malonyltransferase, S-acyl fatty acid synthase thioesterase, enoyl-[acyl-carrier-protein] reductase, and 3-hydroxypalmitoyl-[acyl-carrier-protein] dehydratase.|||[Alpha(6)beta(6)] hexamers of two multifunctional subunits (alpha and beta). http://togogenome.org/gene/284811:AGOS_AER283W ^@ http://purl.uniprot.org/uniprot/Q756H8 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/284811:AGOS_ADR090W ^@ http://purl.uniprot.org/uniprot/Q75A30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat SEC31 family.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).|||Endoplasmic reticulum membrane|||The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. SEC13 and SEC31 make a 2:2 tetramer that forms the edge element of the COPII outer coat. The tetramer self-assembles in multiple copies to form the complete polyhedral cage. Interacts (via WD 8) with SEC13 (By similarity). http://togogenome.org/gene/284811:AGOS_ABL006C ^@ http://purl.uniprot.org/uniprot/Q75DM3 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/284811:AGOS_ACR224C ^@ http://purl.uniprot.org/uniprot/Q75BP7 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284811:AGOS_ACR265C ^@ http://purl.uniprot.org/uniprot/Q75BK6 ^@ Similarity ^@ Belongs to the TRAPP small subunits family. BET3 subfamily. http://togogenome.org/gene/284811:AGOS_AGR303W ^@ http://purl.uniprot.org/uniprot/Q74ZA0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily.|||Nucleus|||Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II (By similarity). http://togogenome.org/gene/284811:AGOS_AER341W ^@ http://purl.uniprot.org/uniprot/Q756C6 ^@ Function|||Similarity ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37. http://togogenome.org/gene/284811:AGOS_AFR427W ^@ http://purl.uniprot.org/uniprot/Q753Q7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Component of the 20S proteasome chaperone.|||Involved in 20S proteasome assembly. http://togogenome.org/gene/284811:AGOS_AFR575C ^@ http://purl.uniprot.org/uniprot/Q752J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL153W ^@ http://purl.uniprot.org/uniprot/Q758A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAL099C ^@ http://purl.uniprot.org/uniprot/Q75F27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL327W ^@ http://purl.uniprot.org/uniprot/Q75BG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaJ family.|||Mitochondrion membrane|||Probable chaperone. http://togogenome.org/gene/284811:AGOS_ABL061C ^@ http://purl.uniprot.org/uniprot/Q75E84 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/284811:AGOS_AAL001W ^@ http://purl.uniprot.org/uniprot/Q75ES9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs. http://togogenome.org/gene/284811:AGOS_AGL032C ^@ http://purl.uniprot.org/uniprot/Q750I3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/284811:AGOS_ABR154C ^@ http://purl.uniprot.org/uniprot/Q75D69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR714W ^@ http://purl.uniprot.org/uniprot/Q751W1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG22 family.|||Vacuolar effluxer which mediate the efflux of amino acids resulting from autophagic degradation. The release of autophagic amino acids allows the maintenance of protein synthesis and viability during nitrogen starvation (By similarity).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ABR044C ^@ http://purl.uniprot.org/uniprot/Q75DI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LU7TM family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR154W ^@ http://purl.uniprot.org/uniprot/Q759W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL396W ^@ http://purl.uniprot.org/uniprot/Q75BF8 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/284811:AGOS_AGR375W ^@ http://purl.uniprot.org/uniprot/Q74Z31 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/284811:AGOS_AFR108W ^@ http://purl.uniprot.org/uniprot/Q754G2 ^@ Function|||Similarity ^@ Belongs to the arrestin family. PalF/RIM8 subfamily.|||Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. http://togogenome.org/gene/284811:AGOS_AGR048C ^@ http://purl.uniprot.org/uniprot/Q750A9 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Activated by tyrosine and threonine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. HOG1 sub-subfamily.|||Cytoplasm|||Dually phosphorylated on Thr-174 and Tyr-176, which activates the enzyme.|||Mitogen-activated protein kinase involved in a signal transduction pathway that is activated by changes in the osmolarity of the extracellular environment. Controls osmotic regulation of transcription of target genes (By similarity).|||Nucleus|||The TXY motif contains the threonine and tyrosine residues whose phosphorylation activates the MAP kinases. http://togogenome.org/gene/284811:AGOS_ADR178W ^@ http://purl.uniprot.org/uniprot/Q759U5 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/284811:AGOS_AGL068W ^@ http://purl.uniprot.org/uniprot/Q750Z9 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/284811:AGOS_ACL166W ^@ http://purl.uniprot.org/uniprot/Q75CT5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 18 family. http://togogenome.org/gene/284811:AGOS_ADL101C ^@ http://purl.uniprot.org/uniprot/Q75AM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_ABR248W ^@ http://purl.uniprot.org/uniprot/Q75DB1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_ADR315W ^@ http://purl.uniprot.org/uniprot/Q759G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL140C ^@ http://purl.uniprot.org/uniprot/Q75F68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL369C ^@ http://purl.uniprot.org/uniprot/Q75BD5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRL1/IGF2R family.|||Endosome membrane|||Sorting receptor involved in the transport of vacuolar enzymes from the Golgi complex to the vacuole.|||trans-Golgi network membrane http://togogenome.org/gene/284811:AGOS_ACR176C ^@ http://purl.uniprot.org/uniprot/Q75BU5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||G proteins are composed of 3 units, alpha, beta and gamma.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL192W ^@ http://purl.uniprot.org/uniprot/Q758F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/284811:AGOS_ABL141C ^@ http://purl.uniprot.org/uniprot/Q75E14 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat IPI3/WDR18 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/284811:AGOS_AMI002W ^@ http://purl.uniprot.org/uniprot/P62514 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heme-copper respiratory oxidase family.|||Binds 2 heme A groups non-covalently per subunit.|||Binds a copper B center.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR338C ^@ http://purl.uniprot.org/uniprot/Q74Z68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/284811:AGOS_AFR037W ^@ http://purl.uniprot.org/uniprot/Q754N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR344C ^@ http://purl.uniprot.org/uniprot/Q753G8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AAR141W ^@ http://purl.uniprot.org/uniprot/Q75EE0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer. Interacts with TAH18. Interacts with MIA40.|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/284811:AGOS_ADL318C ^@ http://purl.uniprot.org/uniprot/Q75B88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EME1/MMS4 family.|||Interacts with MUS81 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI) (By similarity).|||Interacts with MUS81.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL197C ^@ http://purl.uniprot.org/uniprot/Q75E67 ^@ Function|||Similarity|||Subunit ^@ As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II subunit RPO21 to trigger its proteolysis; plays a role in global genomic repair.|||Belongs to the ELA1 family.|||Heterodimer with ELC1. Component of a CRL3 E3 ubiquitin ligase complex consisting of a cullin, the linker protein ELC1, the substrate receptor ELA1, and a RING protein. Interacts with the large RNA polymerase II subunit RPO21 in a manner dependent on DEF1. http://togogenome.org/gene/284811:AGOS_ABR162W ^@ http://purl.uniprot.org/uniprot/Q75D61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL039W ^@ http://purl.uniprot.org/uniprot/Q757Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||DNA polymerase that functions in several pathways of DNA repair. Involved in base excision repair (BER) responsible for repair of lesions that give rise to abasic (AP) sites in DNA. Also contributes to DNA double-strand break repair by non-homologous end joining and homologous recombination. Has both template-dependent and template-independent (terminal transferase) DNA polymerase activities. Has also a 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR118W ^@ http://purl.uniprot.org/uniprot/Q75C01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. Seems to control the nucleotide-dependent binding of SSC1 to substrate proteins (By similarity).|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AFR679C ^@ http://purl.uniprot.org/uniprot/Q751Z6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/284811:AGOS_AER290C ^@ http://purl.uniprot.org/uniprot/Q756H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/284811:AGOS_ABL191W ^@ http://purl.uniprot.org/uniprot/Q75E61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in cytoplasm to vacuole transport (Cvt) and autophagy by mediating both proteolytic activation and delipidation of ATG8. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. The protease activity is required for proteolytic activation of ATG8: cleaves the C-terminal amino acid of ATG8 to reveal a C-terminal glycine. ATG8 ubiquitin-like activity requires the exposure of the glycine at the C-terminus for its conjugation to phosphatidylethanolamine (PE) and its insertion to membranes, which is necessary for autophagy. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy. In addition to the protease activity, also catalyzes deconjugation of PE-conjugated forms of ATG8 during macroautophagy: ATG8 delipidation is required to release the protein from membranes, which facilitates multiple events during macroautophagy, and especially for efficient autophagosome biogenesis, the assembly of ATG9-containing tubulovesicular clusters into phagophores/autophagosomes, and for the disassembly of PAS-associated ATG components. ATG8 delipidation by ATG4 also recycles ATG8-PE generated on inappropriate membranes to maintain a reservoir of unlipidated ATG8 that is required for autophagosome formation at the PAS.|||Cytoplasm|||Nucleus|||Preautophagosomal structure http://togogenome.org/gene/284811:AGOS_AGL257W ^@ http://purl.uniprot.org/uniprot/Q751G3 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/284811:AGOS_ACL172C ^@ http://purl.uniprot.org/uniprot/Q75CU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGR197C ^@ http://purl.uniprot.org/uniprot/Q74ZK3 ^@ PTM|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Phosphorylated. http://togogenome.org/gene/284811:AGOS_AER445C ^@ http://purl.uniprot.org/uniprot/Q755S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_AER344W ^@ http://purl.uniprot.org/uniprot/Q756C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CEF1 family.|||Cytoplasm|||Involved in mRNA splicing and cell cycle control.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR074C ^@ http://purl.uniprot.org/uniprot/Q74ZY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the midasin family.|||Nuclear chaperone required for maturation and nuclear export of pre-60S ribosome subunits.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_AAL146W ^@ http://purl.uniprot.org/uniprot/Q75F74 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/284811:AGOS_AFR172C ^@ http://purl.uniprot.org/uniprot/Q754A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR446W ^@ http://purl.uniprot.org/uniprot/Q752X7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/284811:AGOS_ABR245C ^@ http://purl.uniprot.org/uniprot/Q75CX7 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AFL053W ^@ http://purl.uniprot.org/uniprot/Q754W9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284811:AGOS_ABL086C ^@ http://purl.uniprot.org/uniprot/Q75DV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGM101 family.|||Performs an essential function in the repair of oxidatively damaged mtDNA that is required for the maintenance of the mitochondrial genome. Binds to DNA (By similarity).|||mitochondrion nucleoid http://togogenome.org/gene/284811:AGOS_AGL159W ^@ http://purl.uniprot.org/uniprot/Q750U8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat TRM82 family.|||Forms a heterodimer with the catalytic subunit TRM8.|||Nucleus|||Required for the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA. In the complex, it is required to stabilize and induce conformational changes of the catalytic subunit. http://togogenome.org/gene/284811:AGOS_AER117W ^@ http://purl.uniprot.org/uniprot/Q756Z6 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/284811:AGOS_ABL175C ^@ http://purl.uniprot.org/uniprot/Q75E45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG9 family.|||Mitochondrion|||Required for respiratory activity and maintenance and expression of the mitochondrial genome. http://togogenome.org/gene/284811:AGOS_AER150W ^@ http://purl.uniprot.org/uniprot/Q756V1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. FKBP3/4 subfamily.|||Inhibited by both FK506 and rapamycin.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL144C ^@ http://purl.uniprot.org/uniprot/Q750T3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/284811:AGOS_AAR053W ^@ http://purl.uniprot.org/uniprot/Q75EM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR139C ^@ http://purl.uniprot.org/uniprot/Q759Y4 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/284811:AGOS_AGR333C ^@ http://purl.uniprot.org/uniprot/Q74Z73 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA.|||Associates in the nucleolus with the 60S and pre-60S ribosomal subunits.|||Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR463C ^@ http://purl.uniprot.org/uniprot/Q752W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL40 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AAL034C ^@ http://purl.uniprot.org/uniprot/Q75EW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL287C ^@ http://purl.uniprot.org/uniprot/Q75B59 ^@ Cofactor|||Similarity ^@ Belongs to the chorismate synthase family.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/284811:AGOS_AGL065C ^@ http://purl.uniprot.org/uniprot/Q750M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL122W ^@ http://purl.uniprot.org/uniprot/Q757Y2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/284811:AGOS_ACR103C ^@ http://purl.uniprot.org/uniprot/Q75C14 ^@ Similarity ^@ Belongs to the peptidase S9B family. http://togogenome.org/gene/284811:AGOS_AFR200W ^@ http://purl.uniprot.org/uniprot/Q753X2 ^@ Function|||Similarity ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/284811:AGOS_ADR078C ^@ http://purl.uniprot.org/uniprot/Q75A41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 16 family. CRR1 subfamily.|||Spore specific glycosidase involved in spore wall assembly during sporulation. May be involved in copper import (By similarity).|||Spore wall http://togogenome.org/gene/284811:AGOS_AGR122C ^@ http://purl.uniprot.org/uniprot/Q74ZS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation. In the nucleus, involved in both mRNA cleavage and polyadenylation. Is also required for efficient mRNA export to the cytoplasm. Acts in concert with a poly(A)-specific nuclease (PAN) to affect poly(A) tail shortening, which may occur concomitantly with either nucleocytoplasmic mRNA transport or translational initiation. In the cytoplasm, stimulates translation initiation and regulates mRNA decay through translation termination-coupled poly(A) shortening, probably mediated by PAN (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR359W ^@ http://purl.uniprot.org/uniprot/Q759B8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||High-conductance magnesium-selective channel that mediates the influx of magnesium into the mitochondrial matrix. Essential for the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing. It also suppresses a variety of mitochondrial intron mutations and its absence may disturb the assembly of mitochondrial membrane complexes.|||Homopentamer. Forms homooligomers. Interacts with MFM1.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL303W ^@ http://purl.uniprot.org/uniprot/Q751Q9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatFAB amidotransferase (AdT) complex, composed of A, B and F subunits. http://togogenome.org/gene/284811:AGOS_ABL080W ^@ http://purl.uniprot.org/uniprot/Q75DV3 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AGR328C ^@ http://purl.uniprot.org/uniprot/Q74Z78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL188W ^@ http://purl.uniprot.org/uniprot/Q75E58 ^@ Similarity ^@ Belongs to the AIM6 family. http://togogenome.org/gene/284811:AGOS_ADL308C ^@ http://purl.uniprot.org/uniprot/Q75B80 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/284811:AGOS_AGR163W ^@ http://purl.uniprot.org/uniprot/Q74ZN5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284811:AGOS_AGL351W ^@ http://purl.uniprot.org/uniprot/Q751S4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_ADL096W ^@ http://purl.uniprot.org/uniprot/Q75AL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR220W ^@ http://purl.uniprot.org/uniprot/Q759Q3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL231W ^@ http://purl.uniprot.org/uniprot/Q751D7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of coenzyme Q (CoQ) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABL004W ^@ http://purl.uniprot.org/uniprot/Q75DM1 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/284811:AGOS_ADR277C ^@ http://purl.uniprot.org/uniprot/Q759K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP14 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ABR218C ^@ http://purl.uniprot.org/uniprot/Q75D04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YEL1 family.|||Bud neck|||Bud tip|||Cell membrane|||Cytoplasm|||Guanine nucleotide exchange factor for ARF3 required for localization of ARF3 to the bud neck and tip and involved in actin patch polarization. http://togogenome.org/gene/284811:AGOS_ADL003C ^@ http://purl.uniprot.org/uniprot/Q75AC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/284811:AGOS_ACR147C ^@ http://purl.uniprot.org/uniprot/Q75BX4 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/284811:AGOS_AAL115W ^@ http://purl.uniprot.org/uniprot/Q75F43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_AFR558C ^@ http://purl.uniprot.org/uniprot/P62507 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Component of the large subunit of mitochondrial ribosome.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR213C ^@ http://purl.uniprot.org/uniprot/Q74ZI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR133C ^@ http://purl.uniprot.org/uniprot/Q74ZR5 ^@ Similarity ^@ Belongs to the SCC4/mau-2 family. http://togogenome.org/gene/284811:AGOS_AAL042W ^@ http://purl.uniprot.org/uniprot/Q75EX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL077W ^@ http://purl.uniprot.org/uniprot/Q751A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR335C ^@ http://purl.uniprot.org/uniprot/Q759E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).|||clathrin-coated vesicle membrane http://togogenome.org/gene/284811:AGOS_ADL275C ^@ http://purl.uniprot.org/uniprot/Q75B52 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284811:AGOS_AER095W ^@ http://purl.uniprot.org/uniprot/Q757B8 ^@ Similarity ^@ Belongs to the CDC73 family. http://togogenome.org/gene/284811:AGOS_ABR157W ^@ http://purl.uniprot.org/uniprot/Q75D66 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CarB family.|||Binds 3 Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Cytoplasm|||In eukaryotes this enzyme is synthesized by two pathway-specific (arginine and pyrimidine) under separate control. http://togogenome.org/gene/284811:AGOS_AAL059W ^@ http://purl.uniprot.org/uniprot/Q75EY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts in the GPI biosynthetic pathway between GlcNAc-PI synthesis and GPI transfer to protein.|||Belongs to the PIGF family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ACL205C ^@ http://purl.uniprot.org/uniprot/Q75CX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER119W ^@ http://purl.uniprot.org/uniprot/Q756Z4 ^@ Similarity ^@ Belongs to the TSR2 family. http://togogenome.org/gene/284811:AGOS_AEL170C ^@ http://purl.uniprot.org/uniprot/Q758C2 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284811:AGOS_AAL064W ^@ http://purl.uniprot.org/uniprot/Q75EZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AATF family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL085C ^@ http://purl.uniprot.org/uniprot/Q750N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily.|||Cell membrane|||The plasma membrane ATPase of plants and fungi is a hydrogen ion pump. The proton gradient it generates drives the active transport of nutrients by H(+)-symport. The resulting external acidification and/or internal alkinization may mediate growth responses. http://togogenome.org/gene/284811:AGOS_ADR398W ^@ http://purl.uniprot.org/uniprot/Q758Y0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/284811:AGOS_AGR030C ^@ http://purl.uniprot.org/uniprot/Q750C5 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AFL077C ^@ http://purl.uniprot.org/uniprot/Q755A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KXD1 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1) involved in endosomal cargo sorting.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).|||Endosome http://togogenome.org/gene/284811:AGOS_AER367C ^@ http://purl.uniprot.org/uniprot/Q756A0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/284811:AGOS_AEL013C ^@ http://purl.uniprot.org/uniprot/Q757M7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class I subfamily.|||Binds 1 zinc ion per subunit.|||NAD-dependent deacetylase. Heterochromatin component that silences transcription at silent mating loci, telomeres and the ribosomal DNA, and that also suppresses recombination in the rDNA and extends replicative life span. It acts as a NAD-dependent histone deacetylase, which deacetylates 'Lys-9' and 'Lys-14' of Histone H3 and 'Lys-16' of Histone H4 (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AER098W ^@ http://purl.uniprot.org/uniprot/Q757B5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily. http://togogenome.org/gene/284811:AGOS_ACR102W ^@ http://purl.uniprot.org/uniprot/Q75C15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL172C ^@ http://purl.uniprot.org/uniprot/Q75F88 ^@ Subunit ^@ The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/284811:AGOS_ACR200C ^@ http://purl.uniprot.org/uniprot/Q75BS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACR163W ^@ http://purl.uniprot.org/uniprot/Q75BV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL153W ^@ http://purl.uniprot.org/uniprot/Q755H6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). The SRP complex interacts with the signal sequence in nascent secretory and membrane proteins and directs them to the membrane of the ER.|||Cytoplasm|||nucleolus http://togogenome.org/gene/284811:AGOS_AER103W ^@ http://purl.uniprot.org/uniprot/Q757B0 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/284811:AGOS_AFR437W ^@ http://purl.uniprot.org/uniprot/Q752Z6 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_AFR456C ^@ http://purl.uniprot.org/uniprot/Q752W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPF family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL106C ^@ http://purl.uniprot.org/uniprot/Q75DX9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the reversible hydration of cis-homoaconitate to (2R,3S)-homoisocitrate, a step in the alpha-aminoadipate pathway for lysine biosynthesis.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADL365W ^@ http://purl.uniprot.org/uniprot/Q75BD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AAR021W ^@ http://purl.uniprot.org/uniprot/Q75EQ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protoporphyrinogen/coproporphyrinogen oxidase family. Protoporphyrinogen oxidase subfamily.|||Binds 1 FAD per subunit.|||Catalyzes the 6-electron oxidation of protoporphyrinogen-IX to form protoporphyrin-IX.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR656C ^@ http://purl.uniprot.org/uniprot/Q752B9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR453W ^@ http://purl.uniprot.org/uniprot/Q752X0 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxisomal targeting signal receptor family.|||Interacts (via WxxxF/Y and LVxEF motifs) with PEX14; promoting translocation through the PEX13-PEX14 docking complex.|||Monoubiquitinated at Cys-5 by PEX2 during PEX5 passage through the retrotranslocation channel: monoubiquitination acts as a signal for PEX5 extraction and is required for proper export from peroxisomes and recycling. When PEX5 recycling is compromised, polyubiquitinated at Lys-17 by PEX10 during its passage through the retrotranslocation channel, leading to its degradation.|||Peroxisome matrix|||Receptor that mediates peroxisomal import of proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type). Binds to cargo proteins containing a PTS1 peroxisomal targeting signal in the cytosol, and translocates them into the peroxisome matrix by passing through the PEX13-PEX14 docking complex along with cargo proteins. PEX5 receptor is then retrotranslocated into the cytosol, leading to release of bound cargo in the peroxisome matrix, and reset for a subsequent peroxisome import cycle.|||The TPR repeats mediate interaction with proteins containing a C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type).|||The WxxxF/Y motifs mediate interaction with PEX14, promoting association with the PEX13-PEX14 docking complex.|||The amphipathic helix 1 and 2 (AH1 and AH2, respectively) are required for PEX5 retrotranslocation and recycling. AH2 mediates interaction with lumenal side of the PEX2-PEX10-PEX12 ligase complex, while AH1 is required for extraction from peroxisomal membrane by the PEX1-PEX6 AAA ATPase complex.|||cytosol http://togogenome.org/gene/284811:AGOS_AAR144W ^@ http://purl.uniprot.org/uniprot/Q75ED1 ^@ Function ^@ Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates. http://togogenome.org/gene/284811:AGOS_AEL113C ^@ http://purl.uniprot.org/uniprot/Q757X5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor (By similarity). http://togogenome.org/gene/284811:AGOS_AER404C ^@ http://purl.uniprot.org/uniprot/Q755W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR035C ^@ http://purl.uniprot.org/uniprot/Q750C2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in mitochondrial genome encoded proteins translation. Involved in the binding of tRNA to the ribosomes (By similarity).|||Mitochondrion|||Part of the mitochondrial small ribosomal subunit. http://togogenome.org/gene/284811:AGOS_ADR117W ^@ http://purl.uniprot.org/uniprot/Q75A13 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AEL022W ^@ http://purl.uniprot.org/uniprot/Q757N4 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/284811:AGOS_AGL275W ^@ http://purl.uniprot.org/uniprot/Q751I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. http://togogenome.org/gene/284811:AGOS_AFR211C ^@ http://purl.uniprot.org/uniprot/Q753W1 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/284811:AGOS_ACR097W ^@ http://purl.uniprot.org/uniprot/Q75C20 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/284811:AGOS_AGR006W ^@ http://purl.uniprot.org/uniprot/Q750E9 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the peptidase M67A family. http://togogenome.org/gene/284811:AGOS_AER221W ^@ http://purl.uniprot.org/uniprot/Q756N3 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/284811:AGOS_AFR382W ^@ http://purl.uniprot.org/uniprot/Q753D4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the RSE1 family.|||Involved in pre-mRNA splicing and cell cycle control.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR512W ^@ http://purl.uniprot.org/uniprot/Q752R1 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/284811:AGOS_AFR210C ^@ http://purl.uniprot.org/uniprot/Q753W2 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/284811:AGOS_AAR027W ^@ http://purl.uniprot.org/uniprot/Q75EQ2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/284811:AGOS_ADL302W ^@ http://purl.uniprot.org/uniprot/Q75B74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adaptins are components of the adaptor complexes which link clathrin to receptors in coated vesicles. Clathrin-associated protein complexes are believed to interact with the cytoplasmic tails of membrane proteins, leading to their selection and concentration.|||Belongs to the adaptor complexes large subunit family.|||coated pit http://togogenome.org/gene/284811:AGOS_AEL216C ^@ http://purl.uniprot.org/uniprot/Q758H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER023C ^@ http://purl.uniprot.org/uniprot/Q757J0 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/284811:AGOS_AER209W ^@ http://purl.uniprot.org/uniprot/Q756P5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR063W ^@ http://purl.uniprot.org/uniprot/Q754K9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EAF7 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL068C ^@ http://purl.uniprot.org/uniprot/Q75EZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Cytoplasm|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/284811:AGOS_AEL008W ^@ http://purl.uniprot.org/uniprot/Q757N0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP turnover in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(1) domain and of the central stalk which is part of the complex rotary element. Rotation of the central stalk against the surrounding alpha(3)beta(3) subunits leads to hydrolysis of ATP in three separate catalytic sites on the beta subunits.|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR049W ^@ http://purl.uniprot.org/uniprot/Q75A69 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Forms homooligomers. Interacts with MRS2.|||Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis. Modulates the conductance of the MRS2 channel. Involved in the splicing of mRNA group II introns in mitochondria by affecting mitochondrial magnesium concentrations, which are critical for group II intron splicing.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER316C ^@ http://purl.uniprot.org/uniprot/Q756E9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/284811:AGOS_AGL298C ^@ http://purl.uniprot.org/uniprot/Q751K4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR285C ^@ http://purl.uniprot.org/uniprot/Q75BI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 15 family.|||Component of the Mediator complex, a coactivator involved in regulated gene transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR229C ^@ http://purl.uniprot.org/uniprot/Q75A04 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL333W ^@ http://purl.uniprot.org/uniprot/Q758T5 ^@ Function|||Similarity ^@ Belongs to the phosphatase 2A regulatory subunit.|||The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. http://togogenome.org/gene/284811:AGOS_AAR050C ^@ http://purl.uniprot.org/uniprot/Q75EM9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR112C ^@ http://purl.uniprot.org/uniprot/Q75DB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAR164C ^@ http://purl.uniprot.org/uniprot/Q75EB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR731W ^@ http://purl.uniprot.org/uniprot/Q751U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRB/QCR7 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with cytochrome c oxidase (complex IV, CIV).|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL025W ^@ http://purl.uniprot.org/uniprot/Q75AE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL342W ^@ http://purl.uniprot.org/uniprot/Q75BA9 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/284811:AGOS_AGR012C ^@ http://purl.uniprot.org/uniprot/Q750E3 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/284811:AGOS_AFR187C ^@ http://purl.uniprot.org/uniprot/Q753Y5 ^@ Function|||Similarity ^@ Belongs to the IRC19 family.|||Involved in sporulation and maintenance of the mitochondrial DNA. Is probably involved in a pathway contributing to genomic integrity (By similarity). http://togogenome.org/gene/284811:AGOS_AFR367W ^@ http://purl.uniprot.org/uniprot/Q753Q1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Binds 1 FAD per monomer.|||Irreversibly catalyzes the reduction of fumarate to succinate. http://togogenome.org/gene/284811:AGOS_AEL097C ^@ http://purl.uniprot.org/uniprot/Q757V9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/284811:AGOS_AEL255W ^@ http://purl.uniprot.org/uniprot/Q758L6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/284811:AGOS_AAL174C ^@ http://purl.uniprot.org/uniprot/Q75F90 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/284811:AGOS_ADR394W ^@ http://purl.uniprot.org/uniprot/Q758Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VTS1 family.|||Monomer. Binds to RNA.|||P-body|||RNA-binding protein involved in post-transcriptional regulation through transcript degradation.|||cytosol http://togogenome.org/gene/284811:AGOS_ACR138W ^@ http://purl.uniprot.org/uniprot/Q75BY2 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autoacetylation at Lys-252 is required for proper function.|||Belongs to the MYST (SAS/MOZ) family.|||Catalytic component of the NuA4 histone acetyltransferase (HAT) complex which is involved in epigenetic transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4, H3, H2B, H2A and H2A variant H2A.Z (By similarity). Acetylates histone H4 to form H4K5ac, H4K8ac, H4K12ac and H4K16ac, histone H3 to form H3K14ac, and histone H2A to form H2AK4ac and H2AK7ac (By similarity). The NuA4 complex is involved in the DNA damage response and is required for chromosome segregation. The NuA4 complex plays a direct role in repair of DNA double-strand breaks (DSBs) through homologous recombination (By similarity). Recruitment to promoters depends on H3K4me. Also acetylates non-histone proteins (By similarity). In addition to protein acetyltransferase, can use different acyl-CoA substrates, such as 2-hydroxyisobutanoyl-CoA (2-hydroxyisobutyryl-CoA) or (2E)-butenoyl-CoA (crotonyl-CoA), and is able to mediate protein 2-hydroxyisobutyrylation and crotonylation, respectively (By similarity).|||Chromosome|||Component of the NuA4 histone acetyltransferase complex (By similarity). Interacts with arp4 (By similarity).|||Nucleus|||The ESA1-RPD3 motif is common to ESA1 and RPD3 and is required for ESA1 histone acetyl-transferase (HAT) activity and RPD3 histone deacetylase (HDAC) activity. http://togogenome.org/gene/284811:AGOS_AFR564W ^@ http://purl.uniprot.org/uniprot/Q752L0 ^@ Caution|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrial transcription factor that confers selective promoter recognition on the core subunit of the yeast mitochondrial RNA polymerase. Interacts with DNA in a non-specific manner. http://togogenome.org/gene/284811:AGOS_AFR174W ^@ http://purl.uniprot.org/uniprot/Q753Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG1 family.|||Essential for respiratory growth and required for mitochondrial protein synthesis. Required for vacuolar acidification (By similarity).|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR573C ^@ http://purl.uniprot.org/uniprot/Q752K1 ^@ Similarity ^@ In the N-terminal section; belongs to the FGAMS family. http://togogenome.org/gene/284811:AGOS_ADL175W ^@ http://purl.uniprot.org/uniprot/Q75AU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_AFR462C ^@ http://purl.uniprot.org/uniprot/Q752W1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR442C ^@ http://purl.uniprot.org/uniprot/Q752Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL007W ^@ http://purl.uniprot.org/uniprot/Q750L0 ^@ Function|||Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Required for respiration. http://togogenome.org/gene/284811:AGOS_AFR093W ^@ http://purl.uniprot.org/uniprot/Q754I3 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/284811:AGOS_AER458C ^@ http://purl.uniprot.org/uniprot/Q755R0 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/284811:AGOS_AFR603C ^@ http://purl.uniprot.org/uniprot/Q752H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL146W ^@ http://purl.uniprot.org/uniprot/Q75AR6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL138C ^@ http://purl.uniprot.org/uniprot/Q757Z8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG27 family.|||Cytoplasmic vesicle membrane|||Effector of VPS34 phosphatidylinositol 3-phosphate kinase signaling. Regulates the cytoplasm to vacuole transport (Cvt) vesicle formation. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9 (By similarity).|||Golgi apparatus membrane|||Mitochondrion membrane|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_ADR316W ^@ http://purl.uniprot.org/uniprot/Q759G0 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/284811:AGOS_AEL259W ^@ http://purl.uniprot.org/uniprot/Q758M0 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysH subfamily. http://togogenome.org/gene/284811:AGOS_ADR349W ^@ http://purl.uniprot.org/uniprot/Q759C8 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/284811:AGOS_ACL158W ^@ http://purl.uniprot.org/uniprot/Q75CS7 ^@ Similarity ^@ Belongs to the CENP-X/MHF2 family. http://togogenome.org/gene/284811:AGOS_AFL213W ^@ http://purl.uniprot.org/uniprot/Q755M7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ACR048C ^@ http://purl.uniprot.org/uniprot/Q75C68 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/284811:AGOS_AGR192C ^@ http://purl.uniprot.org/uniprot/Q74ZK8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with TRM82.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL253C ^@ http://purl.uniprot.org/uniprot/Q751F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the CRL3 E3 ubiquitin ligase complex; polyubiquitylates monoubiquitylated RNA polymerase II to trigger its proteolysis; plays a role in global genomic repair. Prevents degradation of interacting proteins by the proteasome.|||Belongs to the SKP1 family.|||Cytoplasm|||Heterodimer with ELA1. Component of a CRL3 E3 ubiquitin ligase complex consisting of a cullin, the linker protein ELC1, the substrate receptor ELA1, and a RING protein.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR041W ^@ http://purl.uniprot.org/uniprot/Q75EN8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits. http://togogenome.org/gene/284811:AGOS_AAL030C ^@ http://purl.uniprot.org/uniprot/Q75EV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR328W ^@ http://purl.uniprot.org/uniprot/Q759E9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PAM17 family.|||Component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Component of the PAM complex, at least composed of mtHsp70 (SSC1), MGE1, TIM44, PAM16, PAM17 and PAM18.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL006W ^@ http://purl.uniprot.org/uniprot/Q75AC3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family. NUBP2/CFD1 subfamily.|||Binds 4 [4Fe-4S] clusters per heterotetramer. Contains two stable clusters in the N-termini of NBP35 and two labile, bridging clusters between subunits of the NBP35-CFD1 heterotetramer.|||Component of the cytosolic iron-sulfur (Fe/S) protein assembly (CIA) machinery. Required for maturation of extramitochondrial Fe-S proteins. The NBP35-CFD1 heterotetramer forms a Fe-S scaffold complex, mediating the de novo assembly of an Fe-S cluster and its transfer to target apoproteins. Required for biogenesis and export of both ribosomal subunits, which may reflect a role in assembly of the Fe/S clusters in RLI1, a protein which performs rRNA processing and ribosome export.|||Cytoplasm|||Heterotetramer of 2 NBP35 and 2 CFD1 chains. http://togogenome.org/gene/284811:AGOS_ACR120C ^@ http://purl.uniprot.org/uniprot/Q75BZ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/284811:AGOS_AER127C ^@ http://purl.uniprot.org/uniprot/Q756Y7 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/284811:AGOS_ADR185W ^@ http://purl.uniprot.org/uniprot/Q759T8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Constituent of COPII-coated endoplasmic reticulum-derived transport vesicles. Required for efficient transport of a subset of secretory proteins to the Golgi. Facilitates retrograde transport from the Golgi to the endoplasmic reticulum (By similarity).|||Endoplasmic reticulum membrane|||Golgi apparatus membrane http://togogenome.org/gene/284811:AGOS_AFR144W ^@ http://purl.uniprot.org/uniprot/Q754C6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER375C ^@ http://purl.uniprot.org/uniprot/Q755Z2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL099C ^@ http://purl.uniprot.org/uniprot/Q75AM2 ^@ Similarity|||Subunit ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Tetramer, composed of 2 regulatory (R) and 2 catalytic (C) subunits. In the presence of cAMP it dissociates into 2 active monomeric C subunits and an R dimer (By similarity). http://togogenome.org/gene/284811:AGOS_ABR138C ^@ http://purl.uniprot.org/uniprot/Q75D86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAF1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR733W ^@ http://purl.uniprot.org/uniprot/Q751U2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Required for proper folding and/or the stability of a subset of proteins in the endoplasmic reticulum. Component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. Probably acts by stabilizing the mannosyltransferase GPI14 (By similarity). http://togogenome.org/gene/284811:AGOS_ABR171W ^@ http://purl.uniprot.org/uniprot/Q75D52 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/284811:AGOS_AAL118C ^@ http://purl.uniprot.org/uniprot/Q75F46 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AFR281C ^@ http://purl.uniprot.org/uniprot/Q753N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/284811:AGOS_AAR154W ^@ http://purl.uniprot.org/uniprot/Q75EC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDS23 family.|||Cytoplasm|||Involved in DNA replication and cell separation.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL341W ^@ http://purl.uniprot.org/uniprot/Q758U3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/284811:AGOS_AGL156W ^@ http://purl.uniprot.org/uniprot/Q750U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL098W ^@ http://purl.uniprot.org/uniprot/Q755C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Endoplasmic reticulum membrane|||Mannosylates Man(2)GlcNAc(2)-dolichol diphosphate and Man(1)GlcNAc(2)-dolichol diphosphate to form Man(3)GlcNAc(2)-dolichol diphosphate. http://togogenome.org/gene/284811:AGOS_ABL166W ^@ http://purl.uniprot.org/uniprot/Q75E36 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/284811:AGOS_AER377C ^@ http://purl.uniprot.org/uniprot/Q755Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MET18/MMS19 family.|||Key component of the cytosolic iron-sulfur protein assembly (CIA) complex, a multiprotein complex that mediates the incorporation of iron-sulfur cluster into apoproteins specifically involved in DNA metabolism and genomic integrity. In the CIA complex, MMS19 acts as an adapter between early-acting CIA components and a subset of cellular target iron-sulfur proteins.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR233W ^@ http://purl.uniprot.org/uniprot/Q75CY9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Hydrolase that can remove conjugated ubiquitin from proteins and may therefore play an important regulatory role at the level of protein turnover by preventing degradation. http://togogenome.org/gene/284811:AGOS_AFR058C ^@ http://purl.uniprot.org/uniprot/Q754L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC2 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR282C ^@ http://purl.uniprot.org/uniprot/Q759J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM36 family.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ABR023C ^@ http://purl.uniprot.org/uniprot/Q75DJ9 ^@ Similarity ^@ Belongs to the ISF1/MBR1 family. http://togogenome.org/gene/284811:AGOS_AAR048W ^@ http://purl.uniprot.org/uniprot/Q75EN1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC12 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Guanine nucleotide-exchange factor (GEF) required for the formation or budding of transport vesicles from the ER. http://togogenome.org/gene/284811:AGOS_ACR006C ^@ http://purl.uniprot.org/uniprot/Q75CA6 ^@ Similarity ^@ Belongs to the UPF0507 family. http://togogenome.org/gene/284811:AGOS_AFL181C ^@ http://purl.uniprot.org/uniprot/Q755Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG2 family.|||Catalyzes the reaction which results in unsaturation at C-7 in the B ring of sterols.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AER200C ^@ http://purl.uniprot.org/uniprot/Q756Q4 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SDHAF2 family.|||Interacts with the flavoprotein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Required for flavinylation (covalent attachment of FAD) of the flavoprotein subunit of the SDH catalytic dimer.|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/284811:AGOS_AGR337W ^@ http://purl.uniprot.org/uniprot/Q74Z69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR543C ^@ http://purl.uniprot.org/uniprot/Q752N1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER400C ^@ http://purl.uniprot.org/uniprot/Q755W8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/284811:AGOS_ACR094C ^@ http://purl.uniprot.org/uniprot/Q75C23 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/284811:AGOS_ABR246W ^@ http://purl.uniprot.org/uniprot/Q75CX6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AEL074W ^@ http://purl.uniprot.org/uniprot/Q757T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ADR006W ^@ http://purl.uniprot.org/uniprot/Q75AB2 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/284811:AGOS_AFR624W ^@ http://purl.uniprot.org/uniprot/Q752F2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL162C ^@ http://purl.uniprot.org/uniprot/Q75F93 ^@ Function|||Similarity ^@ Belongs to the adenylyl cyclase class-3 family.|||Plays essential roles in regulation of cellular metabolism by catalyzing the synthesis of a second messenger, cAMP. http://togogenome.org/gene/284811:AGOS_AER301C ^@ http://purl.uniprot.org/uniprot/Q756G5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in 40S ribosomal subunit biogenesis and is required for the normal formation of 18S rRNAs through pre-rRNA processing at A0, A1 and A2 sites. Required for vegetative growth (By similarity).|||Belongs to the DEAD box helicase family. DDX49/DBP8 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABL123C ^@ http://purl.uniprot.org/uniprot/Q75DZ6 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_ADR092W ^@ http://purl.uniprot.org/uniprot/Q75A28 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/284811:AGOS_AGR391W ^@ http://purl.uniprot.org/uniprot/Q74ZG3 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/284811:AGOS_ADR295C ^@ http://purl.uniprot.org/uniprot/Q759H8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.|||Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/284811:AGOS_ADR066C ^@ http://purl.uniprot.org/uniprot/Q75A53 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Golgi apparatus membrane|||Membrane|||Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. http://togogenome.org/gene/284811:AGOS_AFR142C ^@ http://purl.uniprot.org/uniprot/Q754C8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL267C ^@ http://purl.uniprot.org/uniprot/Q758V1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.|||Belongs to the DNA polymerase epsilon subunit B family.|||Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).|||In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR082W ^@ http://purl.uniprot.org/uniprot/Q75EJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGR165W ^@ http://purl.uniprot.org/uniprot/Q74ZN3 ^@ Similarity ^@ Belongs to the R-transferase family. http://togogenome.org/gene/284811:AGOS_AER214C ^@ http://purl.uniprot.org/uniprot/Q756P0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||By homology to other fibrillarins, some or all of the N-terminal domain arginines are modified to asymmetric dimethylarginine (DMA).|||Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles that contain SNU13, NOP1, SIK1/NOP56 and NOP58, plus a guide RNA.|||S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AEL194W ^@ http://purl.uniprot.org/uniprot/Q758F6 ^@ Similarity ^@ Belongs to the CNOT9 family. http://togogenome.org/gene/284811:AGOS_AFR638C ^@ http://purl.uniprot.org/uniprot/Q752D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPA49/POLR1E RNA polymerase subunit family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACR204C ^@ http://purl.uniprot.org/uniprot/Q75BR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner, facilitating the efficient association of RNA processing factors with their substrates. Component of the cytoplasmic LSM1-LSM7 complex, which is thought to be involved in mRNA degradation by activating the decapping step in the 5'-to-3' mRNA decay pathway. Component of the nuclear LSM2-LSM8 complex, which is involved in splicing of nuclear mRNAs. LSM2-LSM8 associates with multiple snRNP complexes containing the U6 snRNA (U4/U6 di-snRNP, spliceosomal U4/U6.U5 tri-snRNP, and free U6 snRNP). It binds directly to the 3'-terminal U-tract of U6 snRNA and plays a role in the biogenesis and stability of the U6 snRNP and U4/U6 snRNP complexes. LSM2-LSM8 probably also is involved degradation of nuclear pre-mRNA by targeting them for decapping, and in processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).|||Component of the heptameric LSM1-LSM7 complex, which consists of LSM1, LSM2, LSM3, LSM4, LSM5, LSM6 and LSM7. Component of the heptameric LSM2-LSM8 complex, which consists of LSM2, LSM3, LSM4, LSM5, LSM6, LSM7 and LSM8. The LSm subunits form a seven-membered ring structure with a doughnut shape (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL004W ^@ http://purl.uniprot.org/uniprot/Q75CF0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR015C ^@ http://purl.uniprot.org/uniprot/Q75DK6 ^@ Similarity ^@ Belongs to the CENP-C/MIF2 family. http://togogenome.org/gene/284811:AGOS_AGL286C ^@ http://purl.uniprot.org/uniprot/Q751J2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHO1 family.|||Cell membrane|||Forms homooligomers.|||Plasma membrane osmosensor that activates the high osmolarity glycerol (HOG) MAPK signaling pathway in response to high osmolarity. http://togogenome.org/gene/284811:AGOS_ADR235W ^@ http://purl.uniprot.org/uniprot/Q759P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family.|||Controls reversibly actin polymerization and depolymerization in a pH-sensitive manner. It has the ability to bind G- and F-actin in a 1:1 ratio of cofilin to actin. Binding to F-actin is regulated by tropomyosin. It is the major component of intranuclear and cytoplasmic actin rods. Required for accumulation of actin at the cell division site via depolymerizing actin at the cell ends. In association with myosin II has a role in the assembly of the contractile ring via severing actin filaments. Involved in the maintenance of the contractile ring once formed. In association with profilin and capping protein, has a role in the mitotic reorganization of the actin cytoskeleton (By similarity).|||Cytoplasm|||Nucleus matrix|||cytoskeleton http://togogenome.org/gene/284811:AGOS_ADR264C ^@ http://purl.uniprot.org/uniprot/Q759L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR137W ^@ http://purl.uniprot.org/uniprot/Q75BY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the WD repeat PRL1/PRL2 family.|||Cytoplasm|||Involved in pre-mRNA splicing and required for cell cycle progression at G2/M.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR044C ^@ http://purl.uniprot.org/uniprot/Q75A74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the cyclophilin-type PPIase family. CWC27 subfamily.|||Cytoplasm|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Involved in pre-mRNA splicing (By similarity). http://togogenome.org/gene/284811:AGOS_ADL130W ^@ http://purl.uniprot.org/uniprot/Q75AQ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/284811:AGOS_AEL205W ^@ http://purl.uniprot.org/uniprot/Q9HFW2 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Required for hyphal maturation and for septation. http://togogenome.org/gene/284811:AGOS_AFL186W ^@ http://purl.uniprot.org/uniprot/Q755K3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG16 family.|||Homodimer (By similarity). Part of the ATG5-ATG12/ATG16 complex. Several units of each may be present in this complex (By similarity).|||Preautophagosomal structure membrane|||Stabilizes the ATG5-ATG12 conjugate which is necessary for autophagy. The ATG5-ATG12/ATG16 complex is required for efficient promotion of ATG8-conjugation to phosphatidylethanolamine and ATG8 localization to the pre-autophagosomal structure (PAS). Recruits also ATG3 to the PAS. Involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress (By similarity). http://togogenome.org/gene/284811:AGOS_AFR641W ^@ http://purl.uniprot.org/uniprot/Q752D5 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/284811:AGOS_AER419W ^@ http://purl.uniprot.org/uniprot/Q755U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER222C ^@ http://purl.uniprot.org/uniprot/Q756N2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ACL067C ^@ http://purl.uniprot.org/uniprot/Q75CI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOSR1 family.|||Component of several multiprotein Golgi SNARE complexes.|||Golgi apparatus membrane|||Involved in transport from the ER to the Golgi apparatus as well as in intra-Golgi transport. It belongs to a super-family of proteins called t-SNAREs or soluble NSF (N-ethylmaleimide-sensitive factor) attachment protein receptor.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR155W ^@ http://purl.uniprot.org/uniprot/Q754B5 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/284811:AGOS_AGL020W ^@ http://purl.uniprot.org/uniprot/Q750H3 ^@ Subcellular Location Annotation ^@ Membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AAR055W ^@ http://purl.uniprot.org/uniprot/Q75EM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR233W ^@ http://purl.uniprot.org/uniprot/Q75BN8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AER405C ^@ http://purl.uniprot.org/uniprot/Q755W3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL081C ^@ http://purl.uniprot.org/uniprot/Q75AK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of the enzymatic activity (By similarity).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AER116C ^@ http://purl.uniprot.org/uniprot/Q756Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG23 family.|||Cytoplasm|||Membrane|||Required for cytoplasm to vacuole transport (Cvt) vesicle formation and efficient autophagy. Plays a role in ATG protein retrieval from the pre-autophagosomal structure (PAS) and is especially required for autophagy-dependent cycling of ATG9. Also plays a role in regulation of filamentous growth (By similarity). http://togogenome.org/gene/284811:AGOS_ABR054C ^@ http://purl.uniprot.org/uniprot/Q75DH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPC42 family.|||Forms a polymeric layer at the periphery of the spindle pole body (SPB) central plaque which has an essential function during SPB duplication and may facilitate attachment of the SPB to the nuclear membrane.|||Nucleus|||spindle pole body http://togogenome.org/gene/284811:AGOS_ADR020C ^@ http://purl.uniprot.org/uniprot/Q75A98 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AER325W ^@ http://purl.uniprot.org/uniprot/Q756E2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL394C ^@ http://purl.uniprot.org/uniprot/Q752D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL209W ^@ http://purl.uniprot.org/uniprot/Q750Z6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family.|||Binds 2 Zn(2+) ions per subunit.|||May be involved in vacuolar sorting and osmoregulation.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AAL131C ^@ http://purl.uniprot.org/uniprot/Q75F59 ^@ Cofactor|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type II sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Endosome membrane|||Golgi apparatus membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit. Interacts with pstB2. This interaction may be a means to structurally tether the donor membrane (ER) harboring PstB2 to acceptor membranes (Golgi/endosomes) harboring PSD2 during PtdSer transport to the site of PtdEtn synthesis.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||The C2 domains have an essential, but non-catalytic function. They may facilitate interaction with PstB2 and are required for lipid transport function. http://togogenome.org/gene/284811:AGOS_AER252C ^@ http://purl.uniprot.org/uniprot/Q756K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR682C ^@ http://purl.uniprot.org/uniprot/Q751Z3 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/284811:AGOS_AFR087W ^@ http://purl.uniprot.org/uniprot/Q754I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family.|||Cell membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFR443C ^@ http://purl.uniprot.org/uniprot/Q752Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ADL079C ^@ http://purl.uniprot.org/uniprot/Q75AK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL322W ^@ http://purl.uniprot.org/uniprot/Q758S4 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/284811:AGOS_AGR319W ^@ http://purl.uniprot.org/uniprot/Q74Z84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR411W ^@ http://purl.uniprot.org/uniprot/Q758W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the rad1 family.|||Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.|||Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR040C ^@ http://purl.uniprot.org/uniprot/Q75EN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCZ1 family.|||Forms a complex with MON1.|||In complex with MON1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.|||Prevacuolar compartment membrane|||Vacuole membrane|||multivesicular body membrane http://togogenome.org/gene/284811:AGOS_AGR009C ^@ http://purl.uniprot.org/uniprot/Q750E6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFL195W ^@ http://purl.uniprot.org/uniprot/Q755K9 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/284811:AGOS_AAR075C ^@ http://purl.uniprot.org/uniprot/Q75EK4 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/284811:AGOS_AGL361C ^@ http://purl.uniprot.org/uniprot/Q751Q0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR078W ^@ http://purl.uniprot.org/uniprot/Q754J4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM16/PAM16 family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner. In the complex, it is required to regulate activity of mtHSP70 (SSC1) via its interaction with PAM18/TIM14. May act by positioning PAM18/TIM14 in juxtaposition to mtHSP70 at the translocon to maximize ATPase stimulation (By similarity).|||Heterodimer with PAM18. Component of the PAM complex, at least composed of mtHsp70, MGE1, TIM44, PAM16, PAM17 and PAM18 (By similarity).|||Mitochondrion inner membrane|||The J-like region, although related to the J domain does not stimulate ATPase activity of mtHSP70. It nevertheless mediates the heterodimerization with the J domain of PAM18 and is therefore essential for PAM complex function (By similarity). http://togogenome.org/gene/284811:AGOS_AGL031W ^@ http://purl.uniprot.org/uniprot/Q750I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. GMF subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR247W ^@ http://purl.uniprot.org/uniprot/Q75BM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFH5 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Microsome membrane|||Non-classical phosphatidylinositol (PtdIns) transfer protein (PITP), which exhibits PtdIns-binding/transfer activity in the absence of detectable PtdCho-binding/transfer activity. Regulates PtdIns(4,5)P2 homeostasis at the plasma membrane. Heme-binding protein that may play a role in organic oxidant-induced stress responses. http://togogenome.org/gene/284811:AGOS_AGL249C ^@ http://purl.uniprot.org/uniprot/Q751F5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Component of the SRB8-11 complex, a regulatory module of the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL397C ^@ http://purl.uniprot.org/uniprot/Q75BF9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_AFL211W ^@ http://purl.uniprot.org/uniprot/Q755M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP46 family.|||Mitochondrion|||Putative mitochondrial redox protein which could be involved in the reduction of small toxic molecules. http://togogenome.org/gene/284811:AGOS_AGR181W ^@ http://purl.uniprot.org/uniprot/Q74ZL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with nucleolar pre-ribosomal particles.|||Belongs to the RSA3 family.|||Required for efficient biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR178W ^@ http://purl.uniprot.org/uniprot/Q753Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR235W ^@ http://purl.uniprot.org/uniprot/Q75CY7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/284811:AGOS_AAL116W ^@ http://purl.uniprot.org/uniprot/Q75F44 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26S proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the peptidase M67A family. http://togogenome.org/gene/284811:AGOS_ACL098C ^@ http://purl.uniprot.org/uniprot/Q75CL7 ^@ Similarity ^@ Belongs to the DNA2/NAM7 helicase family. http://togogenome.org/gene/284811:AGOS_AEL065C ^@ http://purl.uniprot.org/uniprot/Q757S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGR305W ^@ http://purl.uniprot.org/uniprot/Q74Z98 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/284811:AGOS_AGR259C ^@ http://purl.uniprot.org/uniprot/Q74ZE0 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_ADL346W ^@ http://purl.uniprot.org/uniprot/Q75BB3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Binds 1 phosphopantetheine covalently.|||Catalyzes the activation of alpha-aminoadipate by ATP-dependent adenylation and the reduction of activated alpha-aminoadipate by NADPH. The activated alpha-aminoadipate is bound to the phosphopantheinyl group of the enzyme itself before it is reduced to (S)-2-amino-6-oxohexanoate.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/284811:AGOS_ADL388W ^@ http://purl.uniprot.org/uniprot/Q75BF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR193W ^@ http://purl.uniprot.org/uniprot/Q75D29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins (By similarity). http://togogenome.org/gene/284811:AGOS_ADL356C ^@ http://purl.uniprot.org/uniprot/Q75BC3 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/284811:AGOS_AGL146W ^@ http://purl.uniprot.org/uniprot/Q750T5 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase II family. http://togogenome.org/gene/284811:AGOS_ACR250W ^@ http://purl.uniprot.org/uniprot/Q75BM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR356C ^@ http://purl.uniprot.org/uniprot/Q753F8 ^@ PTM|||Similarity ^@ Belongs to the eIF-5A family.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group. http://togogenome.org/gene/284811:AGOS_AFR014C ^@ http://purl.uniprot.org/uniprot/Q754Q8 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/284811:AGOS_ABR203W ^@ http://purl.uniprot.org/uniprot/Q75D19 ^@ Domain|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family. PFA5 subfamily.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284811:AGOS_AFL050W ^@ http://purl.uniprot.org/uniprot/Q754W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC) involved in the nuclear export of capped U snRNAs. The CBC complex is required for efficient pre-mRNA splicing through efficient commitment complex and spliceosome formation; and involved in rRNA processing at sites A0, A1 and A2 (By similarity).|||Component of the nuclear cap-binding complex (CBC).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL353W ^@ http://purl.uniprot.org/uniprot/Q751P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR249W ^@ http://purl.uniprot.org/uniprot/Q75CX5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_ABR110W ^@ http://purl.uniprot.org/uniprot/Q75DB6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/284811:AGOS_ADL239C ^@ http://purl.uniprot.org/uniprot/Q75B16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).|||Cytoplasm|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||The COPII coat is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex, and the protein SAR1. Golgi apparatus membrane; Peripheral membrane protein; Cytoplasmic side. http://togogenome.org/gene/284811:AGOS_AGL212W ^@ http://purl.uniprot.org/uniprot/Q751B8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR078C ^@ http://purl.uniprot.org/uniprot/Q75DS2 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/284811:AGOS_AEL311W ^@ http://purl.uniprot.org/uniprot/Q758R4 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/284811:AGOS_AAL094W ^@ http://purl.uniprot.org/uniprot/Q75F22 ^@ Similarity ^@ Belongs to the APC5 family. http://togogenome.org/gene/284811:AGOS_AFL076W ^@ http://purl.uniprot.org/uniprot/Q755A1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 3 (AP-3) is a heterotetramer composed of 2 large adaptins (APL5 and APL6), a medium adaptin (APM3) and a small adaptin (APS3).|||Belongs to the adaptor complexes large subunit family.|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to the vacuole (By similarity).|||clathrin-coated vesicle membrane http://togogenome.org/gene/284811:AGOS_AFR615W ^@ http://purl.uniprot.org/uniprot/Q752G1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/284811:AGOS_AEL204C ^@ http://purl.uniprot.org/uniprot/E7FHV0 ^@ Similarity ^@ Belongs to the MON2 family. http://togogenome.org/gene/284811:AGOS_AFR024C ^@ http://purl.uniprot.org/uniprot/Q754P8 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/284811:AGOS_AER067C ^@ http://purl.uniprot.org/uniprot/Q757E6 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/284811:AGOS_AGR175C ^@ http://purl.uniprot.org/uniprot/Q74ZM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_ADL065W ^@ http://purl.uniprot.org/uniprot/Q75AJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RGI1 family.|||Cell membrane|||Involved in the control of energetic metabolism and significantly contribute to cell fitness, especially under respiratory growth conditions. http://togogenome.org/gene/284811:AGOS_AEL223C ^@ http://purl.uniprot.org/uniprot/Q758I5 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/284811:AGOS_AER280C ^@ http://purl.uniprot.org/uniprot/Q756I1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AEL042C ^@ http://purl.uniprot.org/uniprot/Q757Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR197W ^@ http://purl.uniprot.org/uniprot/Q759S6 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/284811:AGOS_AEL162W ^@ http://purl.uniprot.org/uniprot/Q758B4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/284811:AGOS_AER174W ^@ http://purl.uniprot.org/uniprot/Q756S9 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/284811:AGOS_AFR361C ^@ http://purl.uniprot.org/uniprot/Q753F3 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/284811:AGOS_ADR399C ^@ http://purl.uniprot.org/uniprot/Q758X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/284811:AGOS_AFR318W ^@ http://purl.uniprot.org/uniprot/Q753J4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AFR454W ^@ http://purl.uniprot.org/uniprot/Q752W9 ^@ Similarity ^@ Belongs to the glycosyltransferase 34 family. http://togogenome.org/gene/284811:AGOS_ADL333C ^@ http://purl.uniprot.org/uniprot/Q75B99 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/284811:AGOS_ACL035C ^@ http://purl.uniprot.org/uniprot/Q75CE1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL326C ^@ http://purl.uniprot.org/uniprot/Q758S8 ^@ Subcellular Location Annotation|||Subunit ^@ Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/284811:AGOS_AFR009W ^@ http://purl.uniprot.org/uniprot/Q754R3 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/284811:AGOS_ADR192C ^@ http://purl.uniprot.org/uniprot/Q759T1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Endomembrane system|||Endosome membrane|||May be required for cytoplasm to vacuole transport (Cvt) and pexophagy.|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures. http://togogenome.org/gene/284811:AGOS_AFR504W ^@ http://purl.uniprot.org/uniprot/Q752R9 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/284811:AGOS_AEL011W ^@ http://purl.uniprot.org/uniprot/Q757M5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_AFR614W ^@ http://purl.uniprot.org/uniprot/Q752G2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MICOS complex subunit Mic12 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR318C ^@ http://purl.uniprot.org/uniprot/Q74Z85 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 16 family. http://togogenome.org/gene/284811:AGOS_AGL165W ^@ http://purl.uniprot.org/uniprot/Q750V4 ^@ Function|||Similarity ^@ Belongs to the proline oxidase family.|||Converts proline to delta-1-pyrroline-5-carboxylate. http://togogenome.org/gene/284811:AGOS_AFL011W ^@ http://purl.uniprot.org/uniprot/Q754T2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_ACL022W ^@ http://purl.uniprot.org/uniprot/Q75CD1 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/284811:AGOS_AGL247C ^@ http://purl.uniprot.org/uniprot/Q751F3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AAL055C ^@ http://purl.uniprot.org/uniprot/Q75EY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR131C ^@ http://purl.uniprot.org/uniprot/Q75BY9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated to ATG12; which is essential for autophagy.|||Conjugated with ATG12.|||Involved in cytoplasm to vacuole transport (Cvt) and autophagic vesicle formation. Autophagy is essential for maintenance of amino acid levels and protein synthesis under nitrogen starvation. Required for selective autophagic degradation of the nucleus (nucleophagy). Also required for mitophagy, which eliminates defective or superfluous mitochondria in order to fulfill cellular energy requirements and prevent excess ROS production. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity).|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_AGR169W ^@ http://purl.uniprot.org/uniprot/Q74ZM9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Monomer. http://togogenome.org/gene/284811:AGOS_AAR049C ^@ http://purl.uniprot.org/uniprot/Q75EN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAD18 family.|||E3 RING-finger protein, member of the UBC2/RAD6 epistasis group. Associates to the E2 ubiquitin conjugating enzyme UBC2/RAD6 to form the UBC2-RAD18 ubiquitin ligase complex involved in postreplicative repair (PRR) of damaged DNA.|||Interacts with E2 UBC2, forming a complex with ubiquitin ligase activity.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL043W ^@ http://purl.uniprot.org/uniprot/Q757Q5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER387C ^@ http://purl.uniprot.org/uniprot/Q755Y1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER224W ^@ http://purl.uniprot.org/uniprot/Q756N0 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/284811:AGOS_AGR314W ^@ http://purl.uniprot.org/uniprot/Q74Z89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ABR033C ^@ http://purl.uniprot.org/uniprot/Q75DJ1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/284811:AGOS_AFR617C ^@ http://purl.uniprot.org/uniprot/Q752F9 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/284811:AGOS_AFL201W ^@ http://purl.uniprot.org/uniprot/Q755L5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AFR319W ^@ http://purl.uniprot.org/uniprot/Q753J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM170 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL173W ^@ http://purl.uniprot.org/uniprot/Q750W2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAC3 family.|||Nucleus envelope http://togogenome.org/gene/284811:AGOS_ACL144C ^@ http://purl.uniprot.org/uniprot/Q75CR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL147W ^@ http://purl.uniprot.org/uniprot/Q75CR6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR681W ^@ http://purl.uniprot.org/uniprot/Q751Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family.|||Cytoplasm|||Membrane|||Probable sterol 3-beta-glucosyltransferase that is not involved in cytoplasm to vacuole transport (Cvt), pexophagy or nonselective autophagy (By similarity). http://togogenome.org/gene/284811:AGOS_ADL073W ^@ http://purl.uniprot.org/uniprot/Q75AK0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/284811:AGOS_AFL095W ^@ http://purl.uniprot.org/uniprot/Q755B8 ^@ Subcellular Location Annotation ^@ Cell surface http://togogenome.org/gene/284811:AGOS_ADL004W ^@ http://purl.uniprot.org/uniprot/Q75AC1 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/284811:AGOS_AFR390C ^@ http://purl.uniprot.org/uniprot/Q753C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNO1 family.|||Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).|||Cytoplasm|||Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL280W ^@ http://purl.uniprot.org/uniprot/Q751I6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 19 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL272C ^@ http://purl.uniprot.org/uniprot/Q751H8 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/284811:AGOS_AEL306C ^@ http://purl.uniprot.org/uniprot/Q758Q9 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Phosphorylation of the TEDS site (Ser-356) is required for the polarization of the actin cytoskeleton. Phosphorylation probably activates the myosin-I ATPase activity (By similarity).|||The myosin motor domain displays actin-stimulated ATPase activity and generates a mechanochemical force.|||The tail domain participates in molecular interactions that specify the role of the motor domain (By similarity). It is composed of several tail homology (TH) domains, namely a putative phospholipid-binding myosin tail domain (also named TH1), an Ala- and Pro-rich domain (TH2), followed by an SH3 domain and a C-terminal acidic domain (TH3).|||Type-I myosin implicated in the organization of the actin cytoskeleton. Required for proper actin cytoskeleton polarization. At the cell cortex, assembles in patch-like structures together with proteins from the actin-polymerizing machinery and promotes actin assembly. Functions as actin nucleation-promoting factor (NPF) for the Arp2/3 complex (By similarity).|||actin patch http://togogenome.org/gene/284811:AGOS_AER237W ^@ http://purl.uniprot.org/uniprot/Q756L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/284811:AGOS_AAR167C ^@ http://purl.uniprot.org/uniprot/Q75EB0 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/284811:AGOS_AFR626W ^@ http://purl.uniprot.org/uniprot/Q752F0 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/284811:AGOS_AER106C ^@ http://purl.uniprot.org/uniprot/Q757A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Autophagy-specific protein that functions in response to autophagy-inducing signals as a scaffold to recruit other ATG proteins to organize pre-autophagosomal structure (PAS) formation. Modulates the timing and magnitude of the autophagy response, such as the size of the sequestering vesicles. Plays particularly a role in pexophagy and nucleophagy (By similarity).|||Belongs to the ATG17 family.|||Cytoplasm|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_AGR114C ^@ http://purl.uniprot.org/uniprot/Q74ZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL068W ^@ http://purl.uniprot.org/uniprot/Q757T0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HUL4 family.|||Component of the TRAMP complex.|||Nucleus|||Probable E3 ubiquitin-protein ligase, component of the TRAMP complex which has a poly(A) RNA polymerase activity and is involved in a post-transcriptional quality control mechanism limiting inappropriate expression of genetic information. Polyadenylation is required for the degradative activity of the exosome on several of its nuclear RNA substrates. http://togogenome.org/gene/284811:AGOS_ACR042C ^@ http://purl.uniprot.org/uniprot/Q75C74 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/284811:AGOS_ABR168W ^@ http://purl.uniprot.org/uniprot/Q75D55 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/284811:AGOS_ACL148C ^@ http://purl.uniprot.org/uniprot/Q75CR7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/284811:AGOS_ACL186W ^@ http://purl.uniprot.org/uniprot/Q75CV2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/284811:AGOS_ACR035W ^@ http://purl.uniprot.org/uniprot/Q75C81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAL003W ^@ http://purl.uniprot.org/uniprot/Q75ET1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AAL069C ^@ http://purl.uniprot.org/uniprot/Q75EZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HDA2/3 family. HDA2 subfamily.|||Nucleus|||Probable component of some histone deacetylase complex.|||Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). http://togogenome.org/gene/284811:AGOS_ABR100W ^@ http://purl.uniprot.org/uniprot/Q75DC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSM3 family.|||Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.|||Forms a fork protection complex (FPC) with TOF1 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL149W ^@ http://purl.uniprot.org/uniprot/Q75CR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADR160W ^@ http://purl.uniprot.org/uniprot/Q759W2 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/284811:AGOS_ACL076W ^@ http://purl.uniprot.org/uniprot/Q75CJ5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/284811:AGOS_ADL167W ^@ http://purl.uniprot.org/uniprot/Q75AT7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/284811:AGOS_AGR290W ^@ http://purl.uniprot.org/uniprot/Q74ZG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/284811:AGOS_AEL345W ^@ http://purl.uniprot.org/uniprot/Q758U7 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AER037C ^@ http://purl.uniprot.org/uniprot/Q757H6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HTP reductase family.|||Catalyzes an early step in riboflavin biosynthesis, the NADPH-dependent reduction of the ribose side chain of 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate, yielding 2,5-diamino-6-ribitylamino-4(3H)-pyrimidinone 5'-phosphate.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AAL058C ^@ http://purl.uniprot.org/uniprot/Q75EY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM24 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR129W ^@ http://purl.uniprot.org/uniprot/Q754E1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AGL168W ^@ http://purl.uniprot.org/uniprot/Q750V7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC15 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR190C ^@ http://purl.uniprot.org/uniprot/Q75D33 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the INA17 family.|||Component of the INA complex (INAC) that promotes the biogenesis of mitochondrial F(1)F(0)-ATP synthase. INAC facilitates the assembly of the peripheral stalk and promotes the assembly of the catalytic F(1)-domain with the membrane-embedded F(0)-domain.|||Component of the inner membrane assembly (INA) complex, composed of INA17 and INA22. Interacts with a subset of F(1)F(0)-ATP synthase subunits of the F(1)-domain and the peripheral stalk.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL224W ^@ http://purl.uniprot.org/uniprot/Q751D0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/284811:AGOS_AAR019W ^@ http://purl.uniprot.org/uniprot/Q75ER0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel. http://togogenome.org/gene/284811:AGOS_ABR098C ^@ http://purl.uniprot.org/uniprot/Q75DC9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER365W ^@ http://purl.uniprot.org/uniprot/Q756A2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom7 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AGL182C ^@ http://purl.uniprot.org/uniprot/Q750X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL301C ^@ http://purl.uniprot.org/uniprot/Q751R9 ^@ Similarity ^@ Belongs to the WD repeat rae1 family. http://togogenome.org/gene/284811:AGOS_ACR015W ^@ http://purl.uniprot.org/uniprot/Q75CE5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins. http://togogenome.org/gene/284811:AGOS_ADL184W ^@ http://purl.uniprot.org/uniprot/Q75AV4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle (By similarity). http://togogenome.org/gene/284811:AGOS_ADR011C ^@ http://purl.uniprot.org/uniprot/Q75AA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent DNA helicase involved in DNA damage repair by homologous recombination and in genome maintenance. Capable of unwinding D-loops. Plays a role in limiting crossover recombinants during mitotic DNA double-strand break (DSB) repair. Component of a FANCM-MHF complex which promotes gene conversion at blocked replication forks, probably by reversal of the stalled fork.|||Belongs to the DEAD box helicase family. DEAH subfamily. FANCM sub-subfamily.|||Interacts with the MHF histone-fold complex to form the FANCM-MHF complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR112C ^@ http://purl.uniprot.org/uniprot/Q75EG6 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Allosterically activated by ATP (By similarity). ATP binding is a prerequisite to magnesium and substrate binding. ATP binds to 2 of the subunits in the homotetramer inducing a closure of these 2 subunits and the release of the C-terminal loop, thereby activating the enzyme (By similarity).|||Belongs to the ISN1 family.|||Homotetramer.|||IMP-specific 5'-nucleotidase involved in IMP (inositol monophosphate) degradation. http://togogenome.org/gene/284811:AGOS_ADL317C ^@ http://purl.uniprot.org/uniprot/Q75B87 ^@ Function|||Similarity ^@ Belongs to the SEC8 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/284811:AGOS_AER315C ^@ http://purl.uniprot.org/uniprot/Q756F0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/284811:AGOS_AFL103C ^@ http://purl.uniprot.org/uniprot/Q755C6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP72 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AMI001W ^@ http://purl.uniprot.org/uniprot/Q7YFV7 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a dinuclear copper A center per subunit.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane|||The signal sequence of COX2 is processed by IMP1. http://togogenome.org/gene/284811:AGOS_AEL071C ^@ http://purl.uniprot.org/uniprot/Q757T3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR077C ^@ http://purl.uniprot.org/uniprot/Q75DE9 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DEF1 family.|||Cytoplasm|||Homodimer; may form higher order oligomers. Interacts with the large RNA polymerase II subunit RPO21; the interaction is direct and serves to bridge RPO21 to the Elongin complex in a manner dependent on transcription stress. Interacts with RAD26.|||Nucleus|||Proteolytically cleaved by the proteasome in response to transcription stress; the resulting N-terminal form constitutes the activated nuclear form and the C-terminal portion is degraded.|||Recruits the ubiquitination machinery to RNA polymerase II for polyubiquitination, removal and degradation, when the transcription-coupled repair (TCR) factor RAD26 fails to efficiently displace stalled RNA polymerase II. Also involved in telomere length regulation. Binds DNA.|||Ubiquitinated.|||telomere http://togogenome.org/gene/284811:AGOS_AEL034W ^@ http://purl.uniprot.org/uniprot/Q757P6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/284811:AGOS_AEL140C ^@ http://purl.uniprot.org/uniprot/Q758A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP12 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL192W ^@ http://purl.uniprot.org/uniprot/Q750Y1 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_AGR123C ^@ http://purl.uniprot.org/uniprot/Q74ZS5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AEL126W ^@ http://purl.uniprot.org/uniprot/Q757Y6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR269C ^@ http://purl.uniprot.org/uniprot/Q75A15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AAR136W ^@ http://purl.uniprot.org/uniprot/Q75EE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL004C ^@ http://purl.uniprot.org/uniprot/Q750F8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.|||Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.|||Component of pre-60S ribosomal complexes.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAL108C ^@ http://purl.uniprot.org/uniprot/Q75F36 ^@ Function ^@ Catalytic subunit in the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/284811:AGOS_AER032W ^@ http://purl.uniprot.org/uniprot/Q757I1 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR207C ^@ http://purl.uniprot.org/uniprot/Q759R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL158C ^@ http://purl.uniprot.org/uniprot/Q750U7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/284811:AGOS_AFR205C ^@ http://purl.uniprot.org/uniprot/Q753W7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AGL324W ^@ http://purl.uniprot.org/uniprot/Q751M1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR244C ^@ http://purl.uniprot.org/uniprot/Q75BM7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIE beta subunit family.|||Nucleus|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase.|||Tetramer of two alpha and two beta chains. http://togogenome.org/gene/284811:AGOS_AFR629W ^@ http://purl.uniprot.org/uniprot/Q752E7 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFL159W ^@ http://purl.uniprot.org/uniprot/Q755I2 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/284811:AGOS_ACR226W ^@ http://purl.uniprot.org/uniprot/Q75BP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Required both for recombination and for the repair of DNA damage caused by X-rays. http://togogenome.org/gene/284811:AGOS_AER189W ^@ http://purl.uniprot.org/uniprot/Q756R5 ^@ Similarity ^@ Belongs to the peptidase M28 family. http://togogenome.org/gene/284811:AGOS_AFR602W ^@ http://purl.uniprot.org/uniprot/Q752H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR077C ^@ http://purl.uniprot.org/uniprot/Q74ZY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR335C ^@ http://purl.uniprot.org/uniprot/Q753H7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PDPK1 subfamily. http://togogenome.org/gene/284811:AGOS_ACL043W ^@ http://purl.uniprot.org/uniprot/Q75CG2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/284811:AGOS_AER126W ^@ http://purl.uniprot.org/uniprot/Q756Y8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL29 family.|||Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) (By similarity).|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL367WA ^@ http://purl.uniprot.org/uniprot/Q751Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase protein 8 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL225W ^@ http://purl.uniprot.org/uniprot/Q75AZ5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 15 family. http://togogenome.org/gene/284811:AGOS_AEL141W ^@ http://purl.uniprot.org/uniprot/Q758A1 ^@ Similarity ^@ Belongs to the UPF0508 family. http://togogenome.org/gene/284811:AGOS_ADR070W ^@ http://purl.uniprot.org/uniprot/Q75A49 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADL336C ^@ http://purl.uniprot.org/uniprot/Q75BA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM3 family.|||Membrane raft http://togogenome.org/gene/284811:AGOS_AAR175C ^@ http://purl.uniprot.org/uniprot/Q75EA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MON1/SAND family.|||In complex with CCZ1, is required for multiple vacuole delivery pathways including the cytoplasm to vacuole transport (Cvt), autophagy, pexophagy and endocytosis. The CCZ1-MON1 complex acts at the fusion of vesicles with the vacuole, through its regulation of the SNARE complex during the coordinated priming and docking stages of fusion, and particularly at the stage of tethering/docking.|||Prevacuolar compartment membrane|||Vacuole membrane|||multivesicular body membrane http://togogenome.org/gene/284811:AGOS_ABL001W ^@ http://purl.uniprot.org/uniprot/Q75DL8 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/284811:AGOS_AGR362C ^@ http://purl.uniprot.org/uniprot/Q74Z44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase e subunit family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL123W ^@ http://purl.uniprot.org/uniprot/Q750R5 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/284811:AGOS_ACR174C ^@ http://purl.uniprot.org/uniprot/Q75BU7 ^@ Similarity ^@ Belongs to the TIP41 family. http://togogenome.org/gene/284811:AGOS_AAL186W ^@ http://purl.uniprot.org/uniprot/Q75FB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase U48 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGR212W ^@ http://purl.uniprot.org/uniprot/Q74ZJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR633W ^@ http://purl.uniprot.org/uniprot/Q752E3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_AEL274C ^@ http://purl.uniprot.org/uniprot/Q758M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER178W ^@ http://purl.uniprot.org/uniprot/Q756S6 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/284811:AGOS_ADR204W ^@ http://purl.uniprot.org/uniprot/Q759R9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ACR260W ^@ http://purl.uniprot.org/uniprot/Q75BL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER354W ^@ http://purl.uniprot.org/uniprot/Q756B3 ^@ Similarity ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily. http://togogenome.org/gene/284811:AGOS_ACL011C ^@ http://purl.uniprot.org/uniprot/Q75CC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM34 family.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_AER028C ^@ http://purl.uniprot.org/uniprot/Q757I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGL030W ^@ http://purl.uniprot.org/uniprot/Q750I1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/284811:AGOS_AGR116W ^@ http://purl.uniprot.org/uniprot/Q74ZT2 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/284811:AGOS_AER278W ^@ http://purl.uniprot.org/uniprot/Q756I3 ^@ Similarity ^@ Belongs to the SAP30 family. http://togogenome.org/gene/284811:AGOS_AAL053C ^@ http://purl.uniprot.org/uniprot/Q75EY1 ^@ Function ^@ Cleaves A-5'-PPP-5'A to yield AMP and ADP. Can cleave all dinucleoside polyphosphates, provided the phosphate chain contains at least 3 phosphates and that 1 of the 2 bases composing the nucleotide is a purine. Is most effective on dinucleoside triphosphates. Negatively regulates intracellular dinucleoside polyphosphate levels, which elevate following heat shock. http://togogenome.org/gene/284811:AGOS_AGR136W ^@ http://purl.uniprot.org/uniprot/Q74ZR2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPP phosphatase family. PP-4 (PP-X) subfamily.|||Binds 2 manganese ions per subunit.|||Catalytic subunit of the histone H2A phosphatase complex (HTP-C) containing PPH3, PSY2 and PSY4.|||Cytoplasm|||Involved in the dephosphorylation and activation of the transcription factor GLN3 in response to nutrient availability. Forms the histone H2A phosphatase complex in association with the regulatory subunits PSY2 and PSY4, which dephosphorylates H2AS128ph (gamma-H2A) that has been displaced from sites of DNA lesions in the double-stranded DNA break repair process. Dephosphorylation is necessary for efficient recovery from the DNA damage checkpoint (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AER241W ^@ http://purl.uniprot.org/uniprot/Q756L3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPC110 family.|||Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Potential role in cross-linking filaments or anchoring other molecules. It is essential for growth (By similarity).|||Homodimer.|||Nucleus|||spindle pole body http://togogenome.org/gene/284811:AGOS_AEL297W ^@ http://purl.uniprot.org/uniprot/Q758Q0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL113C ^@ http://purl.uniprot.org/uniprot/Q75AN5 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/284811:AGOS_AFR625C ^@ http://purl.uniprot.org/uniprot/Q752F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/284811:AGOS_ABL040W ^@ http://purl.uniprot.org/uniprot/Q75DQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGR155C ^@ http://purl.uniprot.org/uniprot/Q74ZP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR050W ^@ http://purl.uniprot.org/uniprot/Q75DR9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLU family.|||Cytoplasm|||May associate with the eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA-binding protein involved in proper cytoplasmic distribution of mitochondria. http://togogenome.org/gene/284811:AGOS_ADL255C ^@ http://purl.uniprot.org/uniprot/Q75B32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRM6/GCD10 family.|||Heterotetramer; composed of two copies of TRM6 and two copies of TRM61.|||Nucleus|||Substrate-binding subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. http://togogenome.org/gene/284811:AGOS_ADL223W ^@ http://purl.uniprot.org/uniprot/Q75AZ3 ^@ Similarity|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Octamer of two non-identical subunits IDH1 and IDH2. http://togogenome.org/gene/284811:AGOS_AEL098W ^@ http://purl.uniprot.org/uniprot/Q757W0 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. MetX family. http://togogenome.org/gene/284811:AGOS_AEL136C ^@ http://purl.uniprot.org/uniprot/Q757Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASP family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR716C ^@ http://purl.uniprot.org/uniprot/Q751V9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/284811:AGOS_AFR271W ^@ http://purl.uniprot.org/uniprot/Q753P1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/284811:AGOS_AGR076C ^@ http://purl.uniprot.org/uniprot/Q74ZY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL153W ^@ http://purl.uniprot.org/uniprot/Q75AS3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of a COP9 signalosome-like (CSN) complex.|||Component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR563C ^@ http://purl.uniprot.org/uniprot/Q752L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER381C ^@ http://purl.uniprot.org/uniprot/Q755Y6 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/284811:AGOS_AAR172W ^@ http://purl.uniprot.org/uniprot/Q75EA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX1 family.|||Catalytic subunit of the SLX1-SLX4 structure-specific endonuclease that resolves DNA secondary structures generated during DNA repair and recombination. Has endonuclease activity towards branched DNA substrates, introducing single-strand cuts in duplex DNA close to junctions with ss-DNA.|||Forms a heterodimer with SLX4.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR168C ^@ http://purl.uniprot.org/uniprot/Q75EA9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/284811:AGOS_AGL311C ^@ http://purl.uniprot.org/uniprot/Q751L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR015W ^@ http://purl.uniprot.org/uniprot/Q754Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||Endoplasmic reticulum membrane|||May participate in the translocation of oligosaccharide from the cytoplasmic side to the lumenal side of the endoplasmic reticulum membrane. http://togogenome.org/gene/284811:AGOS_AFR511C ^@ http://purl.uniprot.org/uniprot/Q752R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL049W ^@ http://purl.uniprot.org/uniprot/Q75AH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Calcium-dependent mitochondrial aspartate and glutamate carrier. Transport of glutamate in mitochondria is required for mitochondrial transamination reactions and ornithine synthesis. Plays also a role in malate-aspartate NADH shuttle, which is critical for growth on acetate and fatty acids (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR283W ^@ http://purl.uniprot.org/uniprot/Q753M9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG32 family.|||Mitochondrion outer membrane|||Mitophagy-specific receptor that recruits the autophagic machinery to mitochondria and regulates selective degradation of mitochondria. Mitophagy contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Recruits ATG11 to the surface of mitochondria. Promotes also autophagy-dependent peroxisome degradation (By similarity).|||Preautophagosomal structure membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGL092W ^@ http://purl.uniprot.org/uniprot/Q751B1 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/284811:AGOS_ABR121C ^@ http://purl.uniprot.org/uniprot/Q75DA3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF2/ABP1 family.|||Involved in the small subunit (SSU) processome assembly and function, and in the 18S rRNA synthesis. Required for the early cleavages at sites A0, A1 and A2 (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AER234W ^@ http://purl.uniprot.org/uniprot/Q756M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER363W ^@ http://purl.uniprot.org/uniprot/Q756A4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/284811:AGOS_ADL285C ^@ http://purl.uniprot.org/uniprot/Q75B57 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/284811:AGOS_AEL044W ^@ http://purl.uniprot.org/uniprot/Q757Q6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. GlgB subfamily. http://togogenome.org/gene/284811:AGOS_ABL099W ^@ http://purl.uniprot.org/uniprot/Q75DX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADR164C ^@ http://purl.uniprot.org/uniprot/Q759V8 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/284811:AGOS_ABL063C ^@ http://purl.uniprot.org/uniprot/Q75DT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPS2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADR272W ^@ http://purl.uniprot.org/uniprot/Q759K5 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/284811:AGOS_ACR261C ^@ http://purl.uniprot.org/uniprot/Q75BL0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL138C ^@ http://purl.uniprot.org/uniprot/Q750S7 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/284811:AGOS_AEL289W ^@ http://purl.uniprot.org/uniprot/Q758P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL50 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ABL190W ^@ http://purl.uniprot.org/uniprot/Q75E60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSU72 phosphatase family.|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs (By similarity).|||Component of the cleavage and polyadenylation factor (CPF) complex.|||Nucleus|||Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). http://togogenome.org/gene/284811:AGOS_AAR183C ^@ http://purl.uniprot.org/uniprot/Q75ED3 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_ADR410C ^@ http://purl.uniprot.org/uniprot/Q758W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-22 family.|||Involved in peroxisome biogenesis.|||Peroxisome membrane http://togogenome.org/gene/284811:AGOS_ABR227C ^@ http://purl.uniprot.org/uniprot/Q75CZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR032W ^@ http://purl.uniprot.org/uniprot/Q750K9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLT11 family.|||Involved in pre-mRNA splicing. Facilitates the cooperative formation of U2/U6 helix II in association with stem II in the spliceosome. Binds to RNA (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR075W ^@ http://purl.uniprot.org/uniprot/Q74ZY3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/284811:AGOS_ADR391W ^@ http://purl.uniprot.org/uniprot/Q758Y6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACL201W ^@ http://purl.uniprot.org/uniprot/Q75CW7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/284811:AGOS_ACL046C ^@ http://purl.uniprot.org/uniprot/Q75CG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDA2 family.|||Cell projection|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR131C ^@ http://purl.uniprot.org/uniprot/Q754D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADL016C ^@ http://purl.uniprot.org/uniprot/Q75AD3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EST3 family.|||Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase (By similarity).|||Component of the telomerase complex.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ABR103C ^@ http://purl.uniprot.org/uniprot/Q75DC3 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/284811:AGOS_AGR357W ^@ http://purl.uniprot.org/uniprot/Q74Z49 ^@ Similarity ^@ Belongs to the asparaginase 1 family. http://togogenome.org/gene/284811:AGOS_ABR223C ^@ http://purl.uniprot.org/uniprot/Q75CZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR248C ^@ http://purl.uniprot.org/uniprot/Q74ZF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 22 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL059C ^@ http://purl.uniprot.org/uniprot/Q75CH8 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/284811:AGOS_AGL046C ^@ http://purl.uniprot.org/uniprot/Q750J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Component of the GSE complex.|||GTPase involved in activation of the TORC1 signaling pathway, which promotes growth and represses autophagy in nutrient-rich conditions. http://togogenome.org/gene/284811:AGOS_AGL087C ^@ http://purl.uniprot.org/uniprot/Q750N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR261W ^@ http://purl.uniprot.org/uniprot/Q74ZD8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/284811:AGOS_AFL175C ^@ http://purl.uniprot.org/uniprot/Q755J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROT1 family.|||Endoplasmic reticulum membrane|||Required for normal levels of the cell wall 1,6-beta-glucan. Involved in a protein folding machinery chaperoning proteins acting in various physiological processes including cell wall synthesis and lysis of autophagic bodies (By similarity). http://togogenome.org/gene/284811:AGOS_ABL036C ^@ http://purl.uniprot.org/uniprot/Q75DQ3 ^@ Function ^@ Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). http://togogenome.org/gene/284811:AGOS_AER204W ^@ http://purl.uniprot.org/uniprot/Q756Q0 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/284811:AGOS_AFR163C ^@ http://purl.uniprot.org/uniprot/Q754A9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/284811:AGOS_AFR687W ^@ http://purl.uniprot.org/uniprot/Q751Y8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Forms a complex with MEC1.|||Forms a complex with the serine/threonine kinase MEC1 which activates checkpoint signaling upon genotoxic stresses. The MEC1-LCD1 complex is recruited to DNA lesions in order to initiates the DNA repair by homologous recombination. Required for cell growth and meiotic recombination (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR491W ^@ http://purl.uniprot.org/uniprot/Q752T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR108C ^@ http://purl.uniprot.org/uniprot/Q75DB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity). http://togogenome.org/gene/284811:AGOS_AGR399C ^@ http://purl.uniprot.org/uniprot/Q74Z08 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS3/PSF3 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/284811:AGOS_AFR022C ^@ http://purl.uniprot.org/uniprot/Q754Q0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFL163C ^@ http://purl.uniprot.org/uniprot/Q755I6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/284811:AGOS_AFR160C ^@ http://purl.uniprot.org/uniprot/Q754H5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Has a role in promoting intracellular calcium ion sequestration via the exchange of calcium ions for hydrogen ions across the vacuolar membrane. Involved also in manganese ion homeostasis via its uptake into the vacuole.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFL203C ^@ http://purl.uniprot.org/uniprot/Q755L7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SVF1 family.|||Cytoplasm|||May be involved in the response to oxidative stress.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR584C ^@ http://purl.uniprot.org/uniprot/Q752J1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ARPC3 family.|||Component of the Arp2/3 complex.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AAR173C ^@ http://purl.uniprot.org/uniprot/Q75EA4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/284811:AGOS_AEL314W ^@ http://purl.uniprot.org/uniprot/Q758R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat MDV1/CAF4 family.|||Involved in mitochondrial fission. Acts as an adapter protein required to form mitochondrial fission complexes. Formation of these complexes is required to promote constriction and fission of the mitochondrial compartment at a late step in mitochondrial division (By similarity).|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ADR099C ^@ http://purl.uniprot.org/uniprot/Q75A21 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284811:AGOS_ABL035C ^@ http://purl.uniprot.org/uniprot/Q75DQ2 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/284811:AGOS_AGL043C ^@ http://purl.uniprot.org/uniprot/Q750J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR596W ^@ http://purl.uniprot.org/uniprot/Q752H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Appears to play a crucial role in the insertion of secretory and membrane polypeptides into the ER. It is required for assembly of membrane and secretory proteins and is essential for cell growth. It interacts with other membrane proteins required for protein translocation. Upon binding to SEC62/63 complex, secretory precursor polypeptides may engage SEC61 to begin membrane penetration event. A cycle of assembly and disassembly of SEC62/63 from SEC61 may govern the activity of the translocase (By similarity).|||Belongs to the SecY/SEC61-alpha family.|||Endoplasmic reticulum membrane|||Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma. http://togogenome.org/gene/284811:AGOS_AFR110C ^@ http://purl.uniprot.org/uniprot/Q754G0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. CHO2 family.|||Catalyzes the first step of the methylation pathway of phosphatidylcholine biosynthesis, the SAM-dependent methylation of phosphatidylethanolamine (PE) to phosphatidylmonomethylethanolamine (PMME).|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ADL077C ^@ http://purl.uniprot.org/uniprot/Q75AK4 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/284811:AGOS_AER064C ^@ http://purl.uniprot.org/uniprot/Q757E9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284811:AGOS_AEL052W ^@ http://purl.uniprot.org/uniprot/Q757R4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF5 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL284C ^@ http://purl.uniprot.org/uniprot/Q751J0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS21 family. http://togogenome.org/gene/284811:AGOS_AGR053W ^@ http://purl.uniprot.org/uniprot/Q750A4 ^@ Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ As accessory component of the DNA polymerase epsilon (DNA polymerase II) participates in chromosomal DNA replication.|||Heterotetramer. Consists of four subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).|||In eukaryotes there are five DNA polymerases: alpha, beta, gamma, delta, and epsilon which are responsible for different reactions of DNA synthesis.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR024W ^@ http://purl.uniprot.org/uniprot/Q75A94 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/284811:AGOS_AAL183W ^@ http://purl.uniprot.org/uniprot/Q75FB4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family. SCS7 subfamily.|||Binds 2 Zn(2+) ions per subunit that likely form a catalytic dimetal center.|||Ceramide hydroxylase involved in the hydroxylation of sphingolipid-associated very long chain fatty acids. Postulated to hydroxylate the very long chain fatty acid of dihydroceramides and phytoceramides at C-2.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR127W ^@ http://purl.uniprot.org/uniprot/Q754E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL019W ^@ http://purl.uniprot.org/uniprot/Q757L9 ^@ Similarity ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily. http://togogenome.org/gene/284811:AGOS_AAR064W ^@ http://purl.uniprot.org/uniprot/Q75EL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M76 family.|||Has a dual role in the assembly of mitochondrial ATPase. Acts as a protease that removes N-terminal residues of mitochondrial ATPase CF(0) subunit 6 at the intermembrane space side. Also involved in the correct assembly of the membrane-embedded ATPase CF(0) particle, probably mediating association of subunit 6 with the subunit 9 ring (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AAR096W ^@ http://purl.uniprot.org/uniprot/Q75EI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VMA21 family.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Required for the assembly of the V0 complex of the vacuolar ATPase (V-ATPase) in the endoplasmic reticulum. http://togogenome.org/gene/284811:AGOS_AFR230C ^@ http://purl.uniprot.org/uniprot/Q753U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR330W ^@ http://purl.uniprot.org/uniprot/Q759E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR133W ^@ http://purl.uniprot.org/uniprot/Q75D91 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/284811:AGOS_ACR207W ^@ http://purl.uniprot.org/uniprot/Q75BR4 ^@ Similarity ^@ Belongs to the glycosyltransferase 2 family. http://togogenome.org/gene/284811:AGOS_AEL112C ^@ http://purl.uniprot.org/uniprot/Q757X4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL286C ^@ http://purl.uniprot.org/uniprot/Q758P1 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/284811:AGOS_AER047C ^@ http://purl.uniprot.org/uniprot/Q757G6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR111C ^@ http://purl.uniprot.org/uniprot/Q75C08 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/284811:AGOS_ACL032C ^@ http://purl.uniprot.org/uniprot/Q75CF2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AGR384C ^@ http://purl.uniprot.org/uniprot/Q74Z22 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/284811:AGOS_AGR029W ^@ http://purl.uniprot.org/uniprot/Q750C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR408W ^@ http://purl.uniprot.org/uniprot/Q758X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Endoplasmic reticulum|||Microsome http://togogenome.org/gene/284811:AGOS_AGL188W ^@ http://purl.uniprot.org/uniprot/Q750X7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family.|||Cytoplasm|||Hydrolyzes fatty acids from S-acylated cysteine residues in proteins with a strong preference for palmitoylated G-alpha proteins over other acyl substrates. Mediates the deacylation of G-alpha proteins such as GPA1 in vivo, but has weak or no activity toward palmitoylated Ras proteins. Has weak lysophospholipase activity in vitro; however such activity may not exist in vivo.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL036C ^@ http://purl.uniprot.org/uniprot/Q750I7 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/284811:AGOS_ACL060C ^@ http://purl.uniprot.org/uniprot/Q75CH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Nucleus|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. http://togogenome.org/gene/284811:AGOS_AFR048W ^@ http://purl.uniprot.org/uniprot/Q754M4 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/284811:AGOS_ABR231W ^@ http://purl.uniprot.org/uniprot/Q75CZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YSP2 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL127C ^@ http://purl.uniprot.org/uniprot/Q757Y7 ^@ Function|||Similarity ^@ Belongs to the LST4 family.|||Involved in extracellular amino acid uptake. Required for the protein trafficking from the Golgi to the plasma membrane (By similarity). http://togogenome.org/gene/284811:AGOS_AEL163C ^@ http://purl.uniprot.org/uniprot/Q758B5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COA3 family.|||Component of 250-400 kDa complexes called cytochrome oxidase assembly intermediates or COA complexes.|||Mitochondrion inner membrane|||Required for assembly of cytochrome c oxidase (complex IV). http://togogenome.org/gene/284811:AGOS_AFR030C ^@ http://purl.uniprot.org/uniprot/Q754P2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IBD2 family.|||Part of a checkpoint which monitors spindle integrity and prevents premature exit from mitosis.|||spindle pole http://togogenome.org/gene/284811:AGOS_ADR233W ^@ http://purl.uniprot.org/uniprot/Q759P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WHI5/NRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR192W ^@ http://purl.uniprot.org/uniprot/Q75D31 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AAR160W ^@ http://purl.uniprot.org/uniprot/Q75EB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5.|||Preautophagosomal structure membrane|||Ubiquitin-like protein involved in cytoplasm to vacuole transport (Cvt), autophagy vesicles formation, mitophagy, and nucleophagy. Conjugation with ATG5 through a ubiquitin-like conjugating system involving also ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate functions as an E3-like enzyme which is required for lipidation of ATG8 and ATG8 association to the vesicle membranes (By similarity). http://togogenome.org/gene/284811:AGOS_AFR664W ^@ http://purl.uniprot.org/uniprot/Q752B1 ^@ Similarity ^@ Belongs to the IST1 family. http://togogenome.org/gene/284811:AGOS_AFR705W ^@ http://purl.uniprot.org/uniprot/Q751X0 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/284811:AGOS_ACR028C ^@ http://purl.uniprot.org/uniprot/Q75C88 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR363W ^@ http://purl.uniprot.org/uniprot/Q753F1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the ISY1 family.|||Cytoplasm|||Involved in nuclear pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR049W ^@ http://purl.uniprot.org/uniprot/Q75C67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL041W ^@ http://purl.uniprot.org/uniprot/Q75DQ8 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_AEL168C ^@ http://purl.uniprot.org/uniprot/Q758C0 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/284811:AGOS_AER109W ^@ http://purl.uniprot.org/uniprot/Q757A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cell membrane http://togogenome.org/gene/284811:AGOS_AEL064C ^@ http://purl.uniprot.org/uniprot/Q757S6 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/284811:AGOS_AFR109W ^@ http://purl.uniprot.org/uniprot/Q754G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER217W ^@ http://purl.uniprot.org/uniprot/Q756N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL065C ^@ http://purl.uniprot.org/uniprot/Q75EZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c (By similarity).|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements (By similarity).|||Mitochondrion|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACL108C ^@ http://purl.uniprot.org/uniprot/Q75CM7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YPT35 family.|||Endosome membrane|||Recruits the lipid transfer protein VPS13 to endosomal and vacuolar membranes.|||The PX domain binds phosphatidylinositol 3-phosphate (PtdIns(3)P) which is necessary for peripheral membrane localization.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ACR005W ^@ http://purl.uniprot.org/uniprot/Q75CA7 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/284811:AGOS_AGL285C ^@ http://purl.uniprot.org/uniprot/Q751J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AER086C ^@ http://purl.uniprot.org/uniprot/Q757C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LOT5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR215C ^@ http://purl.uniprot.org/uniprot/Q74ZI7 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/284811:AGOS_AAR090W ^@ http://purl.uniprot.org/uniprot/Q75EI9 ^@ Similarity ^@ Belongs to the TEL2 family. http://togogenome.org/gene/284811:AGOS_AFR013C ^@ http://purl.uniprot.org/uniprot/Q754Q9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded, unassembled or oxidatively damaged polypeptides as well as certain short-lived regulatory proteins in the mitochondrial matrix. May also have a chaperone function in the assembly of inner membrane protein complexes. Participates in the regulation of mitochondrial gene expression and in the maintenance of the integrity of the mitochondrial genome. Binds to mitochondrial DNA in a site-specific manner.|||Belongs to the peptidase S16 family.|||Homohexamer or homoheptamer. Organized in a ring with a central cavity.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_ADR217C ^@ http://purl.uniprot.org/uniprot/Q759Q6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DAD2 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AFR069C ^@ http://purl.uniprot.org/uniprot/Q754K3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABR045W ^@ http://purl.uniprot.org/uniprot/Q75DI0 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/284811:AGOS_AER306C ^@ http://purl.uniprot.org/uniprot/Q756F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RAD52 family.|||Involved in DNA double-strand break (DSB) repair and recombination. Promotes the annealing of complementary single-stranded DNA and by stimulation of the RAD51 recombinase (By similarity).|||Nucleus|||Part of a complex that includes RAD51, RAD52 and RAD59. http://togogenome.org/gene/284811:AGOS_AEL262CA ^@ http://purl.uniprot.org/uniprot/Q758M3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL052C ^@ http://purl.uniprot.org/uniprot/Q75DS8 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_AGR343W ^@ http://purl.uniprot.org/uniprot/Q74Z63 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/284811:AGOS_AGL354C ^@ http://purl.uniprot.org/uniprot/Q751P3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 17 family.|||cell wall http://togogenome.org/gene/284811:AGOS_AGL174W ^@ http://purl.uniprot.org/uniprot/Q750W3 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RKM5 family.|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates 60S ribosomal protein L1. http://togogenome.org/gene/284811:AGOS_ABL161C ^@ http://purl.uniprot.org/uniprot/Q75E31 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR450C ^@ http://purl.uniprot.org/uniprot/Q752X3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/284811:AGOS_ADL271W ^@ http://purl.uniprot.org/uniprot/Q75B48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial ribosomal protein bS1 family.|||Component of the mitochondrial small ribosomal subunit.|||Involved in mitochondrial genome encoded proteins translation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR263C ^@ http://purl.uniprot.org/uniprot/Q753P9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DXO/Dom3Z family.|||Decapping enzyme for NAD-capped RNAs: specifically hydrolyzes the nicotinamide adenine dinucleotide (NAD) cap from a subset of RNAs by removing the entire NAD moiety from the 5'-end of an NAD-capped RNA (By similarity). The NAD-cap is present at the 5'-end of some RNAs and snoRNAs (By similarity). In contrast to the canonical 5'-end N7 methylguanosine (m7G) cap, the NAD cap promotes mRNA decay (By similarity). Also acts as a non-canonical decapping enzyme that removes the entire cap structure of m7G capped or incompletely capped RNAs and mediates their subsequent degradation (PubMed:26101253). Specifically degrades pre-mRNAs with a defective m7G cap and is part of a pre-mRNA capping quality control (PubMed:26101253). Has decapping activity toward incomplete 5'-end m7G cap mRNAs such as unmethylated 5'-end-capped RNA (cap0), while it has no activity toward 2'-O-ribose methylated m7G cap (cap1) (By similarity). Also has 5'-3' exonuclease activity (PubMed:26101253). Also possesses RNA 5'-pyrophosphohydrolase activity by hydrolyzing the 5'-end triphosphate to release pyrophosphates (PubMed:26101253).|||Divalent metal cation.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL337C ^@ http://purl.uniprot.org/uniprot/Q751N4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284811:AGOS_ADL321W ^@ http://purl.uniprot.org/uniprot/Q75B91 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EXO84 family.|||Component of the exocyst complex.|||Involved in the secretory pathway as part of the exocyst complex which tethers secretory vesicles to the sites of exocytosis. Plays a role in both the assembly of the exocyst and the polarization of this complex to specific sites of the plasma membrane for exocytosis. Also involved in assembly of the spliceosome (By similarity).|||secretory vesicle http://togogenome.org/gene/284811:AGOS_AGR268W ^@ http://purl.uniprot.org/uniprot/Q74ZD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HIT family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGR354W ^@ http://purl.uniprot.org/uniprot/Q74Z52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP10 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR129C ^@ http://purl.uniprot.org/uniprot/Q74ZR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR058C ^@ http://purl.uniprot.org/uniprot/Q75DG8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFL207C ^@ http://purl.uniprot.org/uniprot/Q755M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR685C ^@ http://purl.uniprot.org/uniprot/Q751Z0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRM1 family.|||Cell membrane|||Involved in cell fusion during mating by stabilizing the plasma membrane fusion event. http://togogenome.org/gene/284811:AGOS_AER082W ^@ http://purl.uniprot.org/uniprot/Q757D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AFL165W ^@ http://purl.uniprot.org/uniprot/Q755I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC4 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/284811:AGOS_AEL279C ^@ http://purl.uniprot.org/uniprot/Q758N4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL012W ^@ http://purl.uniprot.org/uniprot/Q75CC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Mitochondrion inner membrane|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes (By similarity). http://togogenome.org/gene/284811:AGOS_AFR034W ^@ http://purl.uniprot.org/uniprot/Q754N8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/284811:AGOS_AAR105W ^@ http://purl.uniprot.org/uniprot/Q75EH4 ^@ Subcellular Location Annotation ^@ Nucleus membrane http://togogenome.org/gene/284811:AGOS_ACR052W ^@ http://purl.uniprot.org/uniprot/Q75C64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABR215C ^@ http://purl.uniprot.org/uniprot/Q75D07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM11 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAR047C ^@ http://purl.uniprot.org/uniprot/Q75EN2 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/284811:AGOS_AGL310C ^@ http://purl.uniprot.org/uniprot/Q751L1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/284811:AGOS_AFR479W ^@ http://purl.uniprot.org/uniprot/Q752U4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPC1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR397C ^@ http://purl.uniprot.org/uniprot/Q758Y1 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/284811:AGOS_ACR100C ^@ http://purl.uniprot.org/uniprot/Q75C17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM41 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADR031C ^@ http://purl.uniprot.org/uniprot/Q75A87 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/284811:AGOS_ADL230C ^@ http://purl.uniprot.org/uniprot/Q75B07 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/284811:AGOS_ABR101C ^@ http://purl.uniprot.org/uniprot/Q75DC5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_AEL254W ^@ http://purl.uniprot.org/uniprot/Q758L5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/284811:AGOS_AGL226C ^@ http://purl.uniprot.org/uniprot/Q751D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 12 family.|||Component of the SRB8-11 complex, which itself associates with the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR151W ^@ http://purl.uniprot.org/uniprot/Q75BX0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL024C ^@ http://purl.uniprot.org/uniprot/Q757N6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. ECO subfamily.|||Nucleus|||Probable acetyltransferase required for the establishment of sister chromatid cohesion and couple the processes of cohesion and DNA replication to ensure that only sister chromatids become paired together. In contrast to the structural cohesins, the deposition and establishment factors are required only during S phase. Acts by acetylating the cohesin complex component SMC3 (By similarity). http://togogenome.org/gene/284811:AGOS_AAR147W ^@ http://purl.uniprot.org/uniprot/Q75EC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR304W ^@ http://purl.uniprot.org/uniprot/Q753K8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER052W ^@ http://purl.uniprot.org/uniprot/Q757G1 ^@ Cofactor|||Similarity ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_AER351W ^@ http://purl.uniprot.org/uniprot/Q756B6 ^@ Similarity ^@ Belongs to the uroporphyrinogen-III synthase family. http://togogenome.org/gene/284811:AGOS_AFL026W ^@ http://purl.uniprot.org/uniprot/Q754U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||Nucleus|||Responsible for methylating the 5'-cap structure of mRNAs. http://togogenome.org/gene/284811:AGOS_ACR236W ^@ http://purl.uniprot.org/uniprot/Q75BN5 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/284811:AGOS_AGR335C ^@ http://purl.uniprot.org/uniprot/Q74Z71 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/284811:AGOS_ADL291W ^@ http://purl.uniprot.org/uniprot/Q75B63 ^@ Similarity ^@ Belongs to the IWR1/SLC7A6OS family. http://togogenome.org/gene/284811:AGOS_AGL252W ^@ http://purl.uniprot.org/uniprot/Q751F8 ^@ Function|||Similarity ^@ Belongs to the VPS16 family.|||Essential for vacuolar protein sorting. Required for vacuole biogenesis, stability and to maintain vacuole morphology. http://togogenome.org/gene/284811:AGOS_ADL078C ^@ http://purl.uniprot.org/uniprot/Q75AK5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/284811:AGOS_ADR362C ^@ http://purl.uniprot.org/uniprot/Q759B5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/284811:AGOS_ABR099C ^@ http://purl.uniprot.org/uniprot/Q75DC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin GLFG family.|||Nucleus membrane|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AEL337C ^@ http://purl.uniprot.org/uniprot/Q758T9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL124C ^@ http://purl.uniprot.org/uniprot/Q755E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HOT1 family.|||Nucleus|||Required for a complete transcriptional response to osmotic stress. http://togogenome.org/gene/284811:AGOS_ADL150C ^@ http://purl.uniprot.org/uniprot/Q75AS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDA11 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL164C ^@ http://purl.uniprot.org/uniprot/Q758B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS).|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ACL069C ^@ http://purl.uniprot.org/uniprot/Q75CI8 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/284811:AGOS_AGL295C ^@ http://purl.uniprot.org/uniprot/Q751K1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER156C ^@ http://purl.uniprot.org/uniprot/Q756U6 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/284811:AGOS_ADR158W ^@ http://purl.uniprot.org/uniprot/Q759W4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex (By similarity).|||Endoplasmic reticulum membrane|||The C-terminal short (CTS) helix is essential for catalytic activity. It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates. http://togogenome.org/gene/284811:AGOS_ACL008C ^@ http://purl.uniprot.org/uniprot/Q75CB7 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/284811:AGOS_AER069W ^@ http://purl.uniprot.org/uniprot/Q757E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL201W ^@ http://purl.uniprot.org/uniprot/Q757K0|||http://purl.uniprot.org/uniprot/Q75AX1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling (By similarity).|||Glutarylation at Lys-92 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA (By similarity). http://togogenome.org/gene/284811:AGOS_ACR171C ^@ http://purl.uniprot.org/uniprot/Q75BV0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284811:AGOS_AFR497C ^@ http://purl.uniprot.org/uniprot/Q752S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC4 family.|||Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR134W ^@ http://purl.uniprot.org/uniprot/Q75BY6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. Required for methionine synthesis and maintenance of intact mitochondrial DNA. Involved in telomere maintenance.|||Membrane|||Mitochondrion inner membrane|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AGR201C ^@ http://purl.uniprot.org/uniprot/Q74ZJ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/284811:AGOS_ADR413C ^@ http://purl.uniprot.org/uniprot/Q758W5 ^@ Function|||Similarity ^@ Belongs to the Rab GDI family.|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/284811:AGOS_AFR257W ^@ http://purl.uniprot.org/uniprot/Q753R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL143W ^@ http://purl.uniprot.org/uniprot/Q758A3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL105W ^@ http://purl.uniprot.org/uniprot/Q757W7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S64 family.|||Cell membrane|||Component of the plasma membrane SPS (SSY1-PTR3-SSY5) amino acid sensor complex.|||Protease component of the SPS-sensor system, which regulates the expression of several amino acid-metabolizing enzymes and amino acid- and peptide-permeases in response to extracellular amino acid levels by controlling the activity of two transcription factors, STP1 and STP2. Catalyzes the activation of these transcription factors, which are synthesized as latent cytoplasmic precursors, by proteolytic removal of an N-terminal inhibitory domain containing cytoplasmic retention motifs. SSY5 binds as an inactive protease complex to STP1. In response to extracellular amino acids and dependent on the other SPS-sensor components, the inhibitory propeptide is induced to dissociate, and thereby enables the catalytic domain to process STP1. http://togogenome.org/gene/284811:AGOS_AFL204C ^@ http://purl.uniprot.org/uniprot/Q755L8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL142W ^@ http://purl.uniprot.org/uniprot/Q755G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||May form heterododecamers with RVB1. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR086C ^@ http://purl.uniprot.org/uniprot/Q75A34 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).|||Following transcription stress, the elongating form of RNA polymerase II (RNA pol IIo) is polyubiquitinated via 'Lys-63'-linkages on Lys-1247 at DNA damage sites without leading to degradation: ubiquitination promotes RNA pol IIo backtracking to allow access by the transcription-coupled nucleotide excision repair (TC-NER) machinery. Subsequent DEF1-dependent polyubiquitination by the elongin complex via 'Lys-48'-linkages may lead to proteasome-mediated degradation; presumably at stalled RNA pol II where TC-NER has failed, to halt global transcription and enable 'last resort' DNA repair pathways.|||Nucleus|||The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.|||The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.|||The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed (By similarity). http://togogenome.org/gene/284811:AGOS_ADL207W ^@ http://purl.uniprot.org/uniprot/Q75AX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cyclin family. Cyclin C subfamily.|||Component of the SRB8-11 complex, a regulatory module of the Mediator complex.|||Component of the SRB8-11 complex. The SRB8-11 complex is a regulatory module of the Mediator complex which is itself involved in regulation of basal and activated RNA polymerase II-dependent transcription. The SRB8-11 complex may be involved in the transcriptional repression of a subset of genes regulated by Mediator. It may inhibit the association of the Mediator complex with RNA polymerase II to form the holoenzyme complex. The SRB8-11 complex phosphorylates the C-terminal domain (CTD) of the largest subunit of RNA polymerase II (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR273C ^@ http://purl.uniprot.org/uniprot/Q759K4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NUR1 family.|||Member of a perinuclear network that controls recombination at multiple loci to maintain genome stability. Required for rDNA repeat stability (By similarity).|||Nucleus membrane http://togogenome.org/gene/284811:AGOS_AGR402C ^@ http://purl.uniprot.org/uniprot/Q74Z05 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DCP1 family.|||Component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).|||Component of the decapping complex.|||P-body http://togogenome.org/gene/284811:AGOS_ACR060W ^@ http://purl.uniprot.org/uniprot/Q75C56 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/284811:AGOS_ABL045W ^@ http://purl.uniprot.org/uniprot/Q75DR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLD2 family.|||Cytoplasm|||Has a role in the initiation of DNA replication. Required at S-phase checkpoint (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL031C ^@ http://purl.uniprot.org/uniprot/Q757P3 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/284811:AGOS_ADR293C ^@ http://purl.uniprot.org/uniprot/Q759H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER053C ^@ http://purl.uniprot.org/uniprot/Q757G0 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/284811:AGOS_AGR302C ^@ http://purl.uniprot.org/uniprot/Q74ZA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase involved in the assembly or stability of mitochondrial NADH:ubiquinone oxidoreductase complex (complex I).|||Belongs to the NDUFAF7 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ACR185W ^@ http://purl.uniprot.org/uniprot/Q75BT5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EAF6 family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL148W ^@ http://purl.uniprot.org/uniprot/Q75F76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGL307W ^@ http://purl.uniprot.org/uniprot/Q751K8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus|||Pre-mRNA polyadenylation factor that directly interacts with poly(A) polymerase. http://togogenome.org/gene/284811:AGOS_AAR094W ^@ http://purl.uniprot.org/uniprot/Q75EI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome.|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_ADL062W ^@ http://purl.uniprot.org/uniprot/Q75AI9 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the NAGSA dehydrogenase family.|||In the N-terminal section; belongs to the acetylglutamate kinase family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADL377W ^@ http://purl.uniprot.org/uniprot/Q75BE1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/284811:AGOS_AGR321W ^@ http://purl.uniprot.org/uniprot/Q74ZF7 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/284811:AGOS_AFR704W ^@ http://purl.uniprot.org/uniprot/Q751X1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I LYR family. SDHAF3 subfamily.|||Interacts with the iron-sulfur protein subunit within the SDH catalytic dimer.|||Mitochondrion matrix|||Plays an essential role in the assembly of succinate dehydrogenase (SDH), an enzyme complex (also referred to as respiratory complex II) that is a component of both the tricarboxylic acid (TCA) cycle and the mitochondrial electron transport chain, and which couples the oxidation of succinate to fumarate with the reduction of ubiquinone (coenzyme Q) to ubiquinol. Promotes maturation of the iron-sulfur protein subunit of the SDH catalytic dimer, protecting it from the deleterious effects of oxidants. May act together with SDHAF1. http://togogenome.org/gene/284811:AGOS_ADL233W ^@ http://purl.uniprot.org/uniprot/Q75B10 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminopeptidase that preferentially cleaves di- and tripeptides. Also has low epoxide hydrolase activity (in vitro). Can hydrolyze the epoxide leukotriene LTA(4) but it forms preferentially 5,6-dihydroxy-7,9,11,14-eicosatetraenoic acid rather than the cytokine leukotriene B(4) as the product compared to the homologous mammalian enzyme (in vitro).|||Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AER018C ^@ http://purl.uniprot.org/uniprot/Q757J5 ^@ Similarity ^@ Belongs to the MNN1/MNT family. http://togogenome.org/gene/284811:AGOS_AFR666C ^@ http://purl.uniprot.org/uniprot/Q752A9 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/284811:AGOS_AGL208C ^@ http://purl.uniprot.org/uniprot/Q750Z5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 81 family. http://togogenome.org/gene/284811:AGOS_AAL006C ^@ http://purl.uniprot.org/uniprot/Q75EU1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/284811:AGOS_AFR245W ^@ http://purl.uniprot.org/uniprot/Q753T1 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/284811:AGOS_AFL196W ^@ http://purl.uniprot.org/uniprot/Q755L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL057C ^@ http://purl.uniprot.org/uniprot/Q757R9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL288W ^@ http://purl.uniprot.org/uniprot/Q751J4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/284811:AGOS_AFR282W ^@ http://purl.uniprot.org/uniprot/Q753N0 ^@ Similarity ^@ Belongs to the pantothenate synthetase family. http://togogenome.org/gene/284811:AGOS_AAL021W ^@ http://purl.uniprot.org/uniprot/Q75ET7 ^@ Similarity ^@ Belongs to the acetolactate synthase small subunit family. http://togogenome.org/gene/284811:AGOS_AEL045W ^@ http://purl.uniprot.org/uniprot/Q757Q7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_ABL091C ^@ http://purl.uniprot.org/uniprot/Q75DW4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/284811:AGOS_AER135W ^@ http://purl.uniprot.org/uniprot/Q756X9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMA2 family.|||Involved in spore and ascus formation. Required for the efficient assembly of the precursors of the prospore membrane to a continuous prospore membrane (By similarity).|||Prospore membrane http://togogenome.org/gene/284811:AGOS_AAR127C ^@ http://purl.uniprot.org/uniprot/Q75EF4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL147W ^@ http://purl.uniprot.org/uniprot/Q75E79 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with snRNPs.|||Belongs to the SWT21 family.|||Involved in mRNA splicing. Helps to stabilize the U1 snRNP-5' splice site interaction (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR203C ^@ http://purl.uniprot.org/uniprot/Q753W9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex, which consists of NDC80, NUF2, SPC24 and SPC25.|||Nucleus|||kinetochore http://togogenome.org/gene/284811:AGOS_AER179C ^@ http://purl.uniprot.org/uniprot/Q756S5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/284811:AGOS_ADR005W ^@ http://purl.uniprot.org/uniprot/Q75AB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMP52 family.|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ABL076W ^@ http://purl.uniprot.org/uniprot/Q75DU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM18/AIM46 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL140C ^@ http://purl.uniprot.org/uniprot/Q750S9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS35 family.|||Involved in mitochondrial genome encoded proteins translation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AAR155W ^@ http://purl.uniprot.org/uniprot/Q75EB9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GEP7 family.|||Involved in respiratory growth and required for cell survival in the absence of prohibitins.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ADL376W ^@ http://purl.uniprot.org/uniprot/Q75BE0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR105C ^@ http://purl.uniprot.org/uniprot/Q754G5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP4 subfamily.|||Chromatin interaction component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Is required for NuA4 complex integrity. Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair (By similarity).|||Component of the NuA4 histone acetyltransferase complex, of the INO80 chromatin remodeling complex, and of the SWR1 chromatin remodeling complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR205C ^@ http://purl.uniprot.org/uniprot/Q74ZJ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEN54 family.|||Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body. May be required to embody the molecular ruler of the complex (By similarity).|||tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN2 (By similarity). http://togogenome.org/gene/284811:AGOS_AER250C ^@ http://purl.uniprot.org/uniprot/Q756K4 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/284811:AGOS_AER383W ^@ http://purl.uniprot.org/uniprot/Q755Y4 ^@ Subcellular Location Annotation ^@ Vacuole http://togogenome.org/gene/284811:AGOS_AEL305C ^@ http://purl.uniprot.org/uniprot/Q758Q8 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/284811:AGOS_AGR089C ^@ http://purl.uniprot.org/uniprot/Q74ZW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR050C ^@ http://purl.uniprot.org/uniprot/Q75C66 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_ACR270W ^@ http://purl.uniprot.org/uniprot/Q75BK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily.|||Catalytic component of the decapping complex necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Removes the 7-methyl guanine cap structure from mRNA molecules, yielding a 5'-phosphorylated mRNA fragment and 7m-GDP. Decapping is the major pathway of mRNA degradation in yeast. It occurs through deadenylation, decapping and subsequent 5' to 3' exonucleolytic decay of the transcript body (By similarity).|||Component of the decapping complex.|||P-body http://togogenome.org/gene/284811:AGOS_AFR073C ^@ http://purl.uniprot.org/uniprot/Q754J9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER292C ^@ http://purl.uniprot.org/uniprot/Q756H4 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/284811:AGOS_AER364W ^@ http://purl.uniprot.org/uniprot/Q756A3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-oxoacid dehydrogenase family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/284811:AGOS_ADR332W ^@ http://purl.uniprot.org/uniprot/Q759E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR671W ^@ http://purl.uniprot.org/uniprot/Q752A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AEL144W ^@ http://purl.uniprot.org/uniprot/Q758A4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GON7 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. GON7 likely plays a supporting role to the catalytic subunit KAE1 in the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators (By similarity).|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AAR030W ^@ http://purl.uniprot.org/uniprot/Q75EP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_ACL131W ^@ http://purl.uniprot.org/uniprot/Q75CQ0 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/284811:AGOS_AEL309W ^@ http://purl.uniprot.org/uniprot/Q758R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 11 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR145C ^@ http://purl.uniprot.org/uniprot/Q754C5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/284811:AGOS_ADL161C ^@ http://purl.uniprot.org/uniprot/Q75AT1 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/284811:AGOS_AER061C ^@ http://purl.uniprot.org/uniprot/Q757F2 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/284811:AGOS_AER456W ^@ http://purl.uniprot.org/uniprot/Q752D3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAR034W ^@ http://purl.uniprot.org/uniprot/Q75EP5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AGL340C ^@ http://purl.uniprot.org/uniprot/Q751R6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR444C ^@ http://purl.uniprot.org/uniprot/Q752X9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 two farnesyl pyrophosphate moieties to form squalene. It is the first committed enzyme of the sterol biosynthesis pathway. Required for the biosynthesis of ergosterol (By similarity).|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_ABL074C ^@ http://purl.uniprot.org/uniprot/Q75DU7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM8 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/284811:AGOS_ABR013W ^@ http://purl.uniprot.org/uniprot/Q75DK8 ^@ Similarity ^@ Belongs to the UPL family. K-HECT subfamily. http://togogenome.org/gene/284811:AGOS_ACR149C ^@ http://purl.uniprot.org/uniprot/Q75BX2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/284811:AGOS_AAL050W ^@ http://purl.uniprot.org/uniprot/Q75EX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFL036C ^@ http://purl.uniprot.org/uniprot/Q754Z5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HDDC2 family.|||Catalyzes the dephosphorylation of the nucleoside 5'-monophosphates deoxyadenosine monophosphate (dAMP), deoxycytidine monophosphate (dCMP), deoxyguanosine monophosphate (dGMP) and deoxythymidine monophosphate (dTMP).|||Homodimer. http://togogenome.org/gene/284811:AGOS_ADL013C ^@ http://purl.uniprot.org/uniprot/Q75AD0 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/284811:AGOS_AFR111C ^@ http://purl.uniprot.org/uniprot/Q754F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_AFR632C ^@ http://purl.uniprot.org/uniprot/Q752E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RTC4 family.|||Cytoplasm|||May be involved in a process influencing telomere capping.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL046C ^@ http://purl.uniprot.org/uniprot/Q75EX4 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/284811:AGOS_ACL068W ^@ http://purl.uniprot.org/uniprot/Q75CI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL165C ^@ http://purl.uniprot.org/uniprot/Q758B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL246C ^@ http://purl.uniprot.org/uniprot/Q758K7 ^@ Similarity ^@ Belongs to the WD repeat TAF5 family. http://togogenome.org/gene/284811:AGOS_AGL325W ^@ http://purl.uniprot.org/uniprot/Q751M2 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/284811:AGOS_AGR065W ^@ http://purl.uniprot.org/uniprot/Q74ZZ2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. SWF1 subfamily.|||Endoplasmic reticulum membrane|||Palmitoyltransferase that targets several endosomal SNAREs. Palmitoylates the SNAREs at cysteine residues close to the cytoplasmic end of their transmembrane domain. May have a role in the cellular quality control of transmembrane domain-containing proteins (By similarity).|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284811:AGOS_ACR045W ^@ http://purl.uniprot.org/uniprot/Q75C71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ABL107C ^@ http://purl.uniprot.org/uniprot/Q75DY0 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethan group. http://togogenome.org/gene/284811:AGOS_AGL102W ^@ http://purl.uniprot.org/uniprot/Q751B4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Endoplasmic reticulum membrane|||Functions as a zinc transporter.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL039C ^@ http://purl.uniprot.org/uniprot/Q754Y9 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/284811:AGOS_ACR106C ^@ http://purl.uniprot.org/uniprot/Q75C11 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL189C ^@ http://purl.uniprot.org/uniprot/Q750X8 ^@ Similarity ^@ Belongs to the VPS37 family. http://togogenome.org/gene/284811:AGOS_AGR091W ^@ http://purl.uniprot.org/uniprot/Q74ZV8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP6 subfamily.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).|||Cytoplasm|||Nucleus|||cytoskeleton http://togogenome.org/gene/284811:AGOS_ACL031C ^@ http://purl.uniprot.org/uniprot/Q75CE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIM9 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AER092W ^@ http://purl.uniprot.org/uniprot/Q757C1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/284811:AGOS_AEL109W ^@ http://purl.uniprot.org/uniprot/Q757X1 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/284811:AGOS_ADL260W ^@ http://purl.uniprot.org/uniprot/Q75B37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family.|||Cytoplasm|||Putative tyrosine-protein phosphatase required for protection against superoxide stress. http://togogenome.org/gene/284811:AGOS_AGR185C ^@ http://purl.uniprot.org/uniprot/Q74ZL3 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||May be involved in the control of meiotic sister-chromatid recombination. http://togogenome.org/gene/284811:AGOS_AEL324C ^@ http://purl.uniprot.org/uniprot/Q758S6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR288W ^@ http://purl.uniprot.org/uniprot/Q759I9 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/284811:AGOS_AFL212C ^@ http://purl.uniprot.org/uniprot/Q755M6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.|||Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.|||Cytoplasm|||P-body http://togogenome.org/gene/284811:AGOS_AER131C ^@ http://purl.uniprot.org/uniprot/Q756Y3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGL055C ^@ http://purl.uniprot.org/uniprot/Q750K6 ^@ Function|||Similarity ^@ ATP-dependent kinase that could be involved in endoplasmic reticulum membrane assembly.|||Belongs to the YFH7 family. http://togogenome.org/gene/284811:AGOS_ADL213W ^@ http://purl.uniprot.org/uniprot/Q75AY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL029W ^@ http://purl.uniprot.org/uniprot/Q75DP6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/284811:AGOS_AEL116C ^@ http://purl.uniprot.org/uniprot/Q758E2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/284811:AGOS_AEL055C ^@ http://purl.uniprot.org/uniprot/Q757R7 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/284811:AGOS_AAR170W ^@ http://purl.uniprot.org/uniprot/Q75EA7 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/284811:AGOS_AFR226C ^@ http://purl.uniprot.org/uniprot/Q753U9 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/284811:AGOS_AER254W ^@ http://purl.uniprot.org/uniprot/Q756K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR092W ^@ http://purl.uniprot.org/uniprot/Q75EI7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFL138W ^@ http://purl.uniprot.org/uniprot/Q755G1 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Fungal fatty acid synthetase subunit alpha family. http://togogenome.org/gene/284811:AGOS_ADL108C ^@ http://purl.uniprot.org/uniprot/Q75AN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover. The NOT protein subcomplex negatively regulates the basal and activated transcription of many genes. Preferentially affects TC-type TATA element-dependent transcription. Could directly or indirectly inhibit component(s) of the general transcription machinery.|||Belongs to the CNOT2/3/5 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR424C ^@ http://purl.uniprot.org/uniprot/Q753A0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. Involved in pre-tRNA splicing, probably by affecting the interaction of pre-tRNA with splicing endonuclease (By similarity). http://togogenome.org/gene/284811:AGOS_AFR143C ^@ http://purl.uniprot.org/uniprot/Q754C7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the VPS17 family.|||Component of the retromer complex.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/284811:AGOS_AFR355C ^@ http://purl.uniprot.org/uniprot/Q753F9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL059C ^@ http://purl.uniprot.org/uniprot/Q75AI6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that mono- and dimethylates elongation factor 1-alpha at 'Lys-316'. May play a role in intracellular transport. http://togogenome.org/gene/284811:AGOS_AGL193W ^@ http://purl.uniprot.org/uniprot/Q750Y2 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/284811:AGOS_AAR024W ^@ http://purl.uniprot.org/uniprot/Q75EQ5 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/284811:AGOS_AEL218W ^@ http://purl.uniprot.org/uniprot/Q758I0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Chromosome|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR095C ^@ http://purl.uniprot.org/uniprot/Q75EI4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 18 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL059W ^@ http://purl.uniprot.org/uniprot/Q75E82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACL103W ^@ http://purl.uniprot.org/uniprot/Q75CM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP22 family.|||Mitochondrion inner membrane|||Translation factor specific for subunit 6 of the mitochondrial ATPase. Required for assembly of the CF(0) component of the ATPase (By similarity). http://togogenome.org/gene/284811:AGOS_ADR383C ^@ http://purl.uniprot.org/uniprot/Q758Z4 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the control of meiotic sister-chromatid recombination.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADR274C ^@ http://purl.uniprot.org/uniprot/Q759K3 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase C2 family. PalB/RIM13 subfamily.|||Lacks the conserved Asn residue of the catalytic triad in position 292, which is replaced by an Asp residue.|||Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. http://togogenome.org/gene/284811:AGOS_AFR621C ^@ http://purl.uniprot.org/uniprot/Q752F5 ^@ Similarity ^@ Belongs to the CDC6/cdc18 family. http://togogenome.org/gene/284811:AGOS_ADR256W ^@ http://purl.uniprot.org/uniprot/Q759M0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/284811:AGOS_AFL034W ^@ http://purl.uniprot.org/uniprot/Q754V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL001C ^@ http://purl.uniprot.org/uniprot/Q8J1F5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRC22 family.|||Endoplasmic reticulum membrane|||Is probably involved in a pathway contributing to genomic integrity. http://togogenome.org/gene/284811:AGOS_AER360C ^@ http://purl.uniprot.org/uniprot/Q756A7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although related to the peptidase M24 family, this protein lacks conserved active site residues suggesting that it may lack peptidase activity.|||Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II (By similarity).|||Forms a stable heterodimer with POB3. The SPT16-POB3 dimer weakly associates with multiple molecules of NHP6 to form the FACT complex (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL283W ^@ http://purl.uniprot.org/uniprot/Q751I9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24 family.|||Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AER420C ^@ http://purl.uniprot.org/uniprot/Q755U8 ^@ Similarity ^@ Belongs to the MAD2 family. http://togogenome.org/gene/284811:AGOS_ABR239C ^@ http://purl.uniprot.org/uniprot/Q75CY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BOS1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||SNARE required for protein transport between the ER and the Golgi complex. http://togogenome.org/gene/284811:AGOS_AER267W ^@ http://purl.uniprot.org/uniprot/Q756X2 ^@ Similarity ^@ In the C-terminal section; belongs to the anthranilate synthase component I family. http://togogenome.org/gene/284811:AGOS_AEL261C ^@ http://purl.uniprot.org/uniprot/Q758M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR55 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR292W ^@ http://purl.uniprot.org/uniprot/Q753M0 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/284811:AGOS_ABR029W ^@ http://purl.uniprot.org/uniprot/Q75DS1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase I (Pol I) complex consisting of 14 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ACR230C ^@ http://purl.uniprot.org/uniprot/Q75BP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-13 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/284811:AGOS_ADR095W ^@ http://purl.uniprot.org/uniprot/Q75A25 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/284811:AGOS_AAL142C ^@ http://purl.uniprot.org/uniprot/Q75F70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CBP4 family.|||Essential for the assembly of ubiquinol-cytochrome c reductase. It has a direct effect on the correct occurrence of the Rieske protein, core 4, core 5 and apocytochrome b (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER426C ^@ http://purl.uniprot.org/uniprot/Q755U2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_ACR172W ^@ http://purl.uniprot.org/uniprot/Q75BU9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Cytoplasm|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PAB1 (via PABC domain), conferring substrate specificity of the enzyme complex.|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and with PAB1.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/284811:AGOS_AEL096W ^@ http://purl.uniprot.org/uniprot/Q757V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL024W ^@ http://purl.uniprot.org/uniprot/Q75CD3 ^@ Similarity ^@ Belongs to the UPF0057 (PMP3) family. http://togogenome.org/gene/284811:AGOS_AGR139C ^@ http://purl.uniprot.org/uniprot/Q74ZQ9 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_ADR312W ^@ http://purl.uniprot.org/uniprot/Q759G4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR290W ^@ http://purl.uniprot.org/uniprot/Q75BI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/284811:AGOS_AGR376W ^@ http://purl.uniprot.org/uniprot/Q74Z30 ^@ Similarity ^@ Belongs to the AAR2 family. http://togogenome.org/gene/284811:AGOS_ACL176W ^@ http://purl.uniprot.org/uniprot/Q75CU5 ^@ Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/284811:AGOS_ACR157C ^@ http://purl.uniprot.org/uniprot/Q75BW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPC29 family.|||Component of the spindle pole body (SPB) required for the proper execution of spindle pole body (SPB) duplication. Links the central plaque component SPC42 to the inner plaque component SPC110 (By similarity).|||Nucleus|||spindle pole body http://togogenome.org/gene/284811:AGOS_AEL025W ^@ http://purl.uniprot.org/uniprot/Q757N7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class CDC14 subfamily. http://togogenome.org/gene/284811:AGOS_ADL031W ^@ http://purl.uniprot.org/uniprot/Q75AE8 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/284811:AGOS_AAL067W ^@ http://purl.uniprot.org/uniprot/Q75EZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL67 family.|||Mitochondrion|||Nucleus|||Transcription factor involved in regulation of RNA polymerase II-dependent transcription. Also involved in regulation of mitochondrial DNA recombination, maintenance and repair, and generation of homoplasmic cells (By similarity). http://togogenome.org/gene/284811:AGOS_AGR395W ^@ http://purl.uniprot.org/uniprot/Q74Z12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR330C ^@ http://purl.uniprot.org/uniprot/Q753I2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/284811:AGOS_ADL381W ^@ http://purl.uniprot.org/uniprot/Q75BE5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG14 family.|||Coiled-Coils at the N-terminal half are essential for autophagy.|||Preautophagosomal structure membrane|||Required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. This complex is essential to recruit the ATG8-phosphatidylinositol conjugate and the ATG12-ATG5 conjugate to the pre-autophagosomal structure. ATG14 mediates the specific binding of the VPS34 PI3-kinase complex I to the preautophagosomal structure (PAS) (By similarity).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AEL133C ^@ http://purl.uniprot.org/uniprot/Q757Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR201W ^@ http://purl.uniprot.org/uniprot/Q75D21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CGI121/TPRKB family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. CGI121 acts as an allosteric effector that regulates the t(6)A activity of the complex. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators. CGI121 is not required for tRNA modification (By similarity).|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AER444W ^@ http://purl.uniprot.org/uniprot/Q755S4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR279C ^@ http://purl.uniprot.org/uniprot/Q759J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/284811:AGOS_AER430W ^@ http://purl.uniprot.org/uniprot/Q755T8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of a heterotrimeric complex containing IMP3, IMP4 and MPP10.|||Component of the U3 small nucleolar ribonucleoprotein. Required for the early cleavages at sites A0, A1 and A2 during 18S ribosomal pre-RNA processing (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR736C ^@ http://purl.uniprot.org/uniprot/Q751T9 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/284811:AGOS_AFR274C ^@ http://purl.uniprot.org/uniprot/Q753N8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284811:AGOS_AGR379W ^@ http://purl.uniprot.org/uniprot/Q74Z27 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/284811:AGOS_AEL038C ^@ http://purl.uniprot.org/uniprot/Q757Q0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/284811:AGOS_ADR121W ^@ http://purl.uniprot.org/uniprot/Q75A06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. Has a role in chromosome segregation (By similarity). http://togogenome.org/gene/284811:AGOS_ADL028W ^@ http://purl.uniprot.org/uniprot/Q75AE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AEL035W ^@ http://purl.uniprot.org/uniprot/Q757P7 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/284811:AGOS_AEL058W ^@ http://purl.uniprot.org/uniprot/Q757S0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM9 and 3 copies of TIM10, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM9 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/284811:AGOS_ACL155W ^@ http://purl.uniprot.org/uniprot/Q75CS4 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/284811:AGOS_AFR674C ^@ http://purl.uniprot.org/uniprot/Q752A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER248W ^@ http://purl.uniprot.org/uniprot/Q756K6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Cytoplasm|||In the N-terminal section; belongs to the HesA/MoeB/ThiF family. UBA4 subfamily.|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Acts by mediating the C-terminal thiocarboxylation of sulfur carrier URM1. Its N-terminus first activates URM1 as acyl-adenylate (-COAMP), then the persulfide sulfur on the catalytic cysteine is transferred to URM1 to form thiocarboxylation (-COSH) of its C-terminus. The reaction probably involves hydrogen sulfide that is generated from the persulfide intermediate and that acts as nucleophile towards URM1. Subsequently, a transient disulfide bond is formed. Does not use thiosulfate as sulfur donor; NFS1 probably acting as a sulfur donor for thiocarboxylation reactions. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/284811:AGOS_AER287W ^@ http://purl.uniprot.org/uniprot/Q756W8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/284811:AGOS_ADR382W ^@ http://purl.uniprot.org/uniprot/Q758Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AAL002W ^@ http://purl.uniprot.org/uniprot/Q75ET0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL178W ^@ http://purl.uniprot.org/uniprot/Q755K1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG3 family.|||Cytoplasm|||E2 conjugating enzyme required for the cytoplasm to vacuole transport (Cvt) and autophagy. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Responsible for the E2-like covalent binding of phosphatidylethanolamine to the C-terminal Gly of ATG8. The ATG12-ATG5 conjugate plays a role of an E3 and promotes the transfer of ATG8 from ATG3 to phosphatidylethanolamine (PE). This step is required for the membrane association of ATG8. The formation of the ATG8-phosphatidylethanolamine conjugate is essential for autophagy and for the cytoplasm to vacuole transport (Cvt). The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy (By similarity).|||Monomer. Interacts with ATG8 through an intermediate thioester bond through the C-terminal Gly of ATG8. Also interacts with the 40 amino acid C-terminal region of the E1-like ATG7 enzyme. Interacts also with the ATG12-ATG5 conjugate.|||The N-terminal region is involved in phosphatidylethanolamine-binding and is required for ATG8-PE conjugation.|||The flexible region (FR) is required for ATG7-binding.|||The handle region (HR) contains the ATG8 interaction motif (AIM) and mediates binding to ATG8. It is crucial for the cytoplasm-to-vacuole targeting pathway (By similarity). http://togogenome.org/gene/284811:AGOS_ADL157C ^@ http://purl.uniprot.org/uniprot/Q75AS7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/284811:AGOS_AEL130C ^@ http://purl.uniprot.org/uniprot/Q757Z0 ^@ Similarity ^@ Belongs to the PGA52 family. http://togogenome.org/gene/284811:AGOS_AGL003W ^@ http://purl.uniprot.org/uniprot/Q750F7 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/284811:AGOS_ADR188C ^@ http://purl.uniprot.org/uniprot/Q759T5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/284811:AGOS_AGR369W ^@ http://purl.uniprot.org/uniprot/Q74Z37 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Putative transcription factor. http://togogenome.org/gene/284811:AGOS_ABR172W ^@ http://purl.uniprot.org/uniprot/Q75D51 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/284811:AGOS_ADL345C ^@ http://purl.uniprot.org/uniprot/Q75BB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL127C ^@ http://purl.uniprot.org/uniprot/Q751A7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cation homeostasis and in the regulation of the cation stress signaling cascades.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR007W ^@ http://purl.uniprot.org/uniprot/Q754R5 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Cytoplasm|||Late endosome membrane|||RFU1 is an inhibitor of deubiquitination activity.|||Ubiquitin thioesterase that acts at the late endosome/prevacuolar compartment to recover ubiquitin from ubiquitinated membrane proteins en route to the vacuole. Removes also ubiquitin from soluble proteins targeted to proteasomes. Is essential to maintain a normal level of free ubiquitin. Required for promoting coordination of DNA replication and avoids DNA overreplication (By similarity). http://togogenome.org/gene/284811:AGOS_AER063W ^@ http://purl.uniprot.org/uniprot/Q757F0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fungal cytochrome c oxidase subunit 7a family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ACR109W ^@ http://purl.uniprot.org/uniprot/Q75CE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL083W ^@ http://purl.uniprot.org/uniprot/Q750N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EDS1/RGT1 family.|||Cytoplasm|||Glucose-responsive transcription factor that regulates expression of several glucose transporter (HXT) genes in response to glucose. In the absence of glucose, it functions as a transcriptional repressor, whereas high concentrations of glucose cause it to function as a transcriptional activator. In cells growing on low levels of glucose, has a neutral role, neither repressing nor activating transcription (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL161C ^@ http://purl.uniprot.org/uniprot/Q750V0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 81 family. http://togogenome.org/gene/284811:AGOS_AGR406C ^@ http://purl.uniprot.org/uniprot/Q74Z01 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/284811:AGOS_AEL260C ^@ http://purl.uniprot.org/uniprot/Q758M1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER386W ^@ http://purl.uniprot.org/uniprot/Q755Y2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/284811:AGOS_AAL128C ^@ http://purl.uniprot.org/uniprot/Q75F56 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/284811:AGOS_AFR021W ^@ http://purl.uniprot.org/uniprot/Q754Q1 ^@ Similarity ^@ Belongs to the APC1 family. http://togogenome.org/gene/284811:AGOS_ACR144W ^@ http://purl.uniprot.org/uniprot/Q75BX7 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/284811:AGOS_ADL343C ^@ http://purl.uniprot.org/uniprot/Q75BB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2), composed of at least SUS1, SAC3, THP1, SEM1, and CDC31. TREX-2 contains 2 SUS1 chains. The TREX-2 complex interacts with the nucleoporin NUP1. Component of the 1.8 MDa SAGA transcription coactivator-HAT complex. SAGA is built of 5 distinct domains with specialized functions. Within the SAGA complex, SUS1, SGF11, SGF73 and UBP8 form an additional subcomplex of SAGA called the DUB module (deubiquitination module). Interacts directly with THP1, SAC3, SGF11, and with the RNA polymerase II.|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. At the promoters, SAGA is required for recruitment of the basal transcription machinery. It influences RNA polymerase II transcriptional activity through different activities such as TBP interaction and promoter selectivity, interaction with transcription activators, and chromatin modification through histone acetylation and deubiquitination. Within the SAGA complex, participates in a subcomplex required for deubiquitination of H2B and for the maintenance of steady-state H3 methylation levels. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery. May also be involved in cytoplasmic mRNA decay by interaction with components of P-bodies (By similarity).|||P-body|||nucleoplasm http://togogenome.org/gene/284811:AGOS_AFR628C ^@ http://purl.uniprot.org/uniprot/Q752E8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR070W ^@ http://purl.uniprot.org/uniprot/Q75C47 ^@ Similarity ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily. http://togogenome.org/gene/284811:AGOS_AER390W ^@ http://purl.uniprot.org/uniprot/Q755X8 ^@ Similarity ^@ Belongs to the pex2/pex10/pex12 family. http://togogenome.org/gene/284811:AGOS_AGR193C ^@ http://purl.uniprot.org/uniprot/Q74ZK7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/284811:AGOS_AFR703W ^@ http://purl.uniprot.org/uniprot/Q751X2 ^@ Similarity ^@ In the C-terminal section; belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AAR069W ^@ http://purl.uniprot.org/uniprot/Q75EL0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/284811:AGOS_ADR060C ^@ http://purl.uniprot.org/uniprot/Q75A59 ^@ Function|||Subcellular Location Annotation ^@ Involved in transcriptional activation. Also required for ubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation, telomeric silencing, and is also a prerequisite for H3K4me and H3K79me formation. Its precise role in H2BK123ub1 formation however is unclear (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL152C ^@ http://purl.uniprot.org/uniprot/Q750U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STB3 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADR389C ^@ http://purl.uniprot.org/uniprot/Q758Y8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/284811:AGOS_AGR279C ^@ http://purl.uniprot.org/uniprot/Q74ZC0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER396W ^@ http://purl.uniprot.org/uniprot/Q755X2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG8 family.|||The C-terminal 5 residues are removed by ATG4 to expose Gly-115 at the C-terminus. The C-terminal Gly is then amidated with phosphatidylethanolamine by an activating system similar to that for ubiquitin.|||Ubiquitin-like modifier involved in autophagosomes formation. With ATG4, mediates the delivery of the autophagosomes to the vacuole via the microtubule cytoskeleton. Required for selective autophagic degradation of the nucleus (nucleophagy) as well as for mitophagy which contributes to regulate mitochondrial quantity and quality by eliminating the mitochondria to a basal level to fulfill cellular energy requirements and preventing excess ROS production. Participates also in membrane fusion events that take place in the early secretory pathway. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. The ATG8-PE conjugate mediates tethering between adjacent membranes and stimulates membrane hemifusion, leading to expansion of the autophagosomal membrane during autophagy.|||Vacuole membrane|||autophagosome membrane http://togogenome.org/gene/284811:AGOS_AGL040C ^@ http://purl.uniprot.org/uniprot/Q750J1 ^@ Function|||Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||NAD(+)-dependent glutamate dehydrogenase which degrades glutamate to ammonia and alpha-ketoglutarate. http://togogenome.org/gene/284811:AGOS_AGR374C ^@ http://purl.uniprot.org/uniprot/Q74Z32 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH3 family.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).|||The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. http://togogenome.org/gene/284811:AGOS_AFL141C ^@ http://purl.uniprot.org/uniprot/Q755G4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1) (By similarity). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c'' (By similarity).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ADL352C ^@ http://purl.uniprot.org/uniprot/Q75BB9 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/284811:AGOS_AFR693C ^@ http://purl.uniprot.org/uniprot/Q751Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL276C ^@ http://purl.uniprot.org/uniprot/Q758N1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/284811:AGOS_AFR520W ^@ http://purl.uniprot.org/uniprot/Q752Q3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enhancer of polycomb family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in gene silencing by neighboring heterochromatin, blockage of the silencing spreading along the chromosome, and required for cell cycle progression through G2/M (By similarity).|||Component of the NuA4 histone acetyltransferase complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL058W ^@ http://purl.uniprot.org/uniprot/Q75AI5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Has a role in mitochondrial fission. Has a role in outer membrane fission but not matrix separation (By similarity).|||Mitochondrion outer membrane|||The C-terminus is required for mitochondrial localization, while the N-terminus is necessary for mitochondrial fission. http://togogenome.org/gene/284811:AGOS_AFR285C ^@ http://purl.uniprot.org/uniprot/Q753M7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Component of the 60S subunit of the ribosome.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL183C ^@ http://purl.uniprot.org/uniprot/Q750X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR191C ^@ http://purl.uniprot.org/uniprot/Q759T2 ^@ Similarity ^@ Belongs to the proteasome subunit S11 family. http://togogenome.org/gene/284811:AGOS_AFL155C ^@ http://purl.uniprot.org/uniprot/Q755H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Golgi apparatus membrane|||Probable serine protease.|||cis-Golgi network membrane http://togogenome.org/gene/284811:AGOS_ADR036C ^@ http://purl.uniprot.org/uniprot/Q75A82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adenine nucleotide transporter involved in the uniport of ATP and adenine nucleotide hetero-exchange transport between the cytosol and the peroxisomal lumen. This transport is accompanied by a proton transport from the peroxisomal lumen to the cytosol. Transport of ATP into the peroxisome is required for beta-oxidation of medium-chain fatty acids (By similarity).|||Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Peroxisome membrane http://togogenome.org/gene/284811:AGOS_AGR355C ^@ http://purl.uniprot.org/uniprot/Q74Z51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DAD4 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AFR098W ^@ http://purl.uniprot.org/uniprot/Q754H4 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/284811:AGOS_ACL165C ^@ http://purl.uniprot.org/uniprot/P62583 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Homotetramer.|||Phosphatidylinositol-4-phosphate-binding protein that links Golgi membranes to the cytoskeleton and may participate in the tensile force required for vesicle budding from the Golgi. Thereby, may play a role in Golgi membrane trafficking and could indirectly give its flattened shape to the Golgi apparatus. May also bind to the coatomer to regulate Golgi membrane trafficking. May play a role in anterograde transport from the Golgi to the plasma membrane and regulate secretion. Mediates the cis and medial Golgi localization of mannosyltransferases through direct binding of their cytosolic domains. Involved in vacuolar protein sorting (By similarity). http://togogenome.org/gene/284811:AGOS_ADL076W ^@ http://purl.uniprot.org/uniprot/Q75AK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AEL117C ^@ http://purl.uniprot.org/uniprot/Q757X7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR068C ^@ http://purl.uniprot.org/uniprot/Q75DF8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/284811:AGOS_AAL137W ^@ http://purl.uniprot.org/uniprot/Q75F65 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the THI4 family.|||Binds 1 Fe cation per subunit.|||Cytoplasm|||During the catalytic reaction, a sulfide is transferred from Cys-210 to a reaction intermediate, generating a dehydroalanine residue.|||Homooctamer.|||Involved in biosynthesis of the thiamine precursor thiazole. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylic acid (ADT), an adenylated thiazole intermediate. The reaction includes an iron-dependent sulfide transfer from a conserved cysteine residue of the protein to a thiazole intermediate. The enzyme can only undergo a single turnover, which suggests it is a suicide enzyme. May have additional roles in adaptation to various stress conditions and in DNA damage tolerance.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER345W ^@ http://purl.uniprot.org/uniprot/Q756C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an inhibitor of cap-dependent translation. Competes with eIF4G1 and EAP1 for binding to eIF4E and interferes with the formation of the eIF4F complex, inhibiting translation and stabilizing mRNA (By similarity).|||Belongs to the CAF20 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADR071W ^@ http://purl.uniprot.org/uniprot/Q75A48 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG9 family.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Forms a homotrimer with a solvated central pore, which is connected laterally to the cytosol through the cavity within each protomer. Acts as a lipid scramblase that uses its central pore to function: the central pore opens laterally to accommodate lipid headgroups, thereby enabling lipid flipping and redistribution of lipids added to the outer leaflet of ATG9-containing vesicles, thereby enabling growth into autophagosomes.|||Golgi apparatus membrane|||Homotrimer; forms a homotrimer with a central pore that forms a path between the two membrane leaflets.|||Phospholipid scramblase involved in autophagy and cytoplasm to vacuole transport (Cvt) vesicle formation. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion. Required for mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Different machineries are required for anterograde trafficking to the PAS during either the Cvt pathway or bulk autophagy and for retrograde trafficking.|||Phosphorylated by ATG1. ATG1 phosphorylation is required for preautophagosome elongation.|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_ACR155W ^@ http://purl.uniprot.org/uniprot/Q75BW6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/284811:AGOS_AER369C ^@ http://purl.uniprot.org/uniprot/Q755Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL144C ^@ http://purl.uniprot.org/uniprot/Q75F72 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small Tim family.|||Heterohexamer; composed of 3 copies of TIM8 and 3 copies of TIM13, named soluble 70 kDa complex. Associates with the TIM22 complex, whose core is composed of TIM22 and TIM54. Interacts with the transmembrane regions of multi-pass transmembrane proteins in transit (By similarity).|||Mitochondrial intermembrane chaperone that participates in the import and insertion of some multi-pass transmembrane proteins into the mitochondrial inner membrane. Also required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. The TIM8-TIM13 complex is non essential and only mediates the import of few proteins, while the predominant TIM9-TIM10 70 kDa complex is crucial and mediates the import of much more proteins (By similarity).|||Mitochondrion inner membrane|||The twin CX3C motif contains 4 conserved Cys residues that form 2 disulfide bonds in the mitochondrial intermembrane space. However, during the transit of TIM13 from cytoplasm into mitochondrion, the Cys residues probably coordinate zinc, thereby preventing folding and allowing its transfer across mitochondrial outer membrane (By similarity). http://togogenome.org/gene/284811:AGOS_AAR020W ^@ http://purl.uniprot.org/uniprot/Q75EQ9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR112W ^@ http://purl.uniprot.org/uniprot/Q754F8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR393W ^@ http://purl.uniprot.org/uniprot/Q753C3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHE9 family.|||Homooligomer.|||Mitochondrion inner membrane|||Required for the maintenance of the structure of the mitochondrial inner membrane. Involved in mitochondrial morphology. Causes growth arrest when highly overexpressed (By similarity). http://togogenome.org/gene/284811:AGOS_AFR534W ^@ http://purl.uniprot.org/uniprot/Q752N9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADR137W ^@ http://purl.uniprot.org/uniprot/Q759Y6 ^@ Function|||Subcellular Location Annotation ^@ Component of the cleavage factor IA (CFIA) complex, which is involved in the endonucleolytic cleavage during polyadenylation-dependent pre-mRNA 3'-end formation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AER233C ^@ http://purl.uniprot.org/uniprot/Q756M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 5' to 3' DNA replicative helicase recruited to paused replisomes to promote fork progression throughout nonhistone protein-DNA complexes, naturally occurring impediments that are encountered in each S phase where replication forks pauses. Required for timely replication of the telomere and subtelomeric DNA and for wild-type levels of telomeric silencing. Involved in DNA repair during stalled replication fork, regulation of fragile sites expression and essential for genome stability. Plays also a role in mtDNA replication. Has G-quadruplex (G4) unwinding activity and can suppress G4-induced genome instability when PIF1 levels are low.|||Belongs to the helicase family. PIF1 subfamily.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_AER171W ^@ http://purl.uniprot.org/uniprot/Q756T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OS-9 family.|||Endoplasmic reticulum membrane|||Interacts with missfolded ER lumenal proteins.|||Lectin involved in the quality control of the secretory pathway. As a member of the endoplasmic reticulum-associated degradation lumenal (ERAD-L) surveillance system, targets misfolded endoplasmic reticulum lumenal glycoproteins for degradation (By similarity). http://togogenome.org/gene/284811:AGOS_AGR351W ^@ http://purl.uniprot.org/uniprot/Q74Z55 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/284811:AGOS_ABR075C ^@ http://purl.uniprot.org/uniprot/Q75DF1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTP family.|||Involved in protein synthesis. Involved in microtubule stabilization.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AEL157W ^@ http://purl.uniprot.org/uniprot/Q758A9 ^@ Similarity ^@ Belongs to the PAF1 family. http://togogenome.org/gene/284811:AGOS_AFL114W ^@ http://purl.uniprot.org/uniprot/Q755D7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. SAR1 family.|||COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity). http://togogenome.org/gene/284811:AGOS_AFR306C ^@ http://purl.uniprot.org/uniprot/Q753K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/284811:AGOS_AGR092W ^@ http://purl.uniprot.org/uniprot/Q74ZV7 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/284811:AGOS_ADR367C ^@ http://purl.uniprot.org/uniprot/Q759B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/284811:AGOS_AAL012C ^@ http://purl.uniprot.org/uniprot/O60027 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284811:AGOS_ABL078C ^@ http://purl.uniprot.org/uniprot/Q75DV1 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/284811:AGOS_AGR010C ^@ http://purl.uniprot.org/uniprot/Q750E5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR192W ^@ http://purl.uniprot.org/uniprot/Q753Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OCA5 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR667C ^@ http://purl.uniprot.org/uniprot/Q752A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL243W ^@ http://purl.uniprot.org/uniprot/Q758K5 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/284811:AGOS_AFR440C ^@ http://purl.uniprot.org/uniprot/Q752Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxygen-dependent FAD-linked oxidoreductase family.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ABL072C ^@ http://purl.uniprot.org/uniprot/Q75DU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RIX1/PELP1 family.|||Component of the RIX1 complex required for processing of ITS2 sequences from 35S pre-rRNA and the nucleoplasmic transit of the pre-60S ribosomal subunits. Regulates pre-60S association of the critical remodeling factor MDN1.|||Component of the RIX1 complex, composed of IPI1, RIX1/IPI2 and IPI3 in a 1:2:2 stoichiometry. The complex interacts (via RIX1) with MDN1 (via its hexameric AAA ATPase ring) and the pre-60S ribosome particles.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL072W ^@ http://purl.uniprot.org/uniprot/Q750M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP18 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking. http://togogenome.org/gene/284811:AGOS_AGR364C ^@ http://purl.uniprot.org/uniprot/Q74Z42 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL192W ^@ http://purl.uniprot.org/uniprot/Q75AW2 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/284811:AGOS_ABR124C ^@ http://purl.uniprot.org/uniprot/Q75DA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFL121W ^@ http://purl.uniprot.org/uniprot/Q755E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent serine protease that mediates the selective degradation of misfolded and unassembled polypeptides in the peroxisomal matrix. Necessary for type 2 peroxisome targeting signal (PTS2)-containing protein processing and facilitates peroxisome matrix protein import.|||Belongs to the peptidase S16 family.|||Peroxisome matrix http://togogenome.org/gene/284811:AGOS_AGR233W ^@ http://purl.uniprot.org/uniprot/Q74ZH4 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/284811:AGOS_AGR232C ^@ http://purl.uniprot.org/uniprot/Q74ZH5 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/284811:AGOS_AEL318W ^@ http://purl.uniprot.org/uniprot/Q758S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom20 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AER313C ^@ http://purl.uniprot.org/uniprot/Q756F2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endopolyphosphatase PPN1 family.|||Catalyzes the hydrolysis of inorganic polyphosphate (polyP) chains of many hundreds of phosphate residues into shorter lengths.|||Processing by proteases in the vacuole may be required for activation.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ADR208W ^@ http://purl.uniprot.org/uniprot/Q759R5 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER005C ^@ http://purl.uniprot.org/uniprot/Q757K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the second mannose to the glycosylphosphatidylinositol during GPI precursor assembly (By similarity). http://togogenome.org/gene/284811:AGOS_ACL162C ^@ http://purl.uniprot.org/uniprot/Q75CT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR371W ^@ http://purl.uniprot.org/uniprot/Q753E5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGL117C ^@ http://purl.uniprot.org/uniprot/Q750Q9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Heterodimers with GPN1 or GPN2. Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284811:AGOS_AFL227C ^@ http://purl.uniprot.org/uniprot/Q755P0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YAF9 family.|||Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised (By similarity).|||Cytoplasm|||Nucleus|||The coiled-coil domain is required for assembly into the NuA4 complex. http://togogenome.org/gene/284811:AGOS_ACL146C ^@ http://purl.uniprot.org/uniprot/Q75CR5 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/284811:AGOS_AGR072W ^@ http://purl.uniprot.org/uniprot/Q74ZY6 ^@ Function|||Similarity ^@ Belongs to the LCL2 family.|||Probable component of the endoplasmic reticulum-associated degradation (ERAD) pathway. http://togogenome.org/gene/284811:AGOS_ACL200W ^@ http://purl.uniprot.org/uniprot/Q75CW6 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/284811:AGOS_AGL357W ^@ http://purl.uniprot.org/uniprot/Q751P6 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_AAR166C ^@ http://purl.uniprot.org/uniprot/Q75EB1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL165C ^@ http://purl.uniprot.org/uniprot/Q75E35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RTT106 family.|||Chromosome|||Histones H3 and H4 chaperone involved in the nucleosome formation and heterochromatin silencing. Required for the deposition of H3K56ac-carrying H3-H4 complex onto newly-replicated DNA. Plays a role in the transcriptional regulation of the cell-cycle dependent histone genes by creating a repressive structure at the core histone gene promoter (By similarity).|||Interacts with histones H3 and H4.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR395C ^@ http://purl.uniprot.org/uniprot/Q758Y3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/284811:AGOS_AGL346W ^@ http://purl.uniprot.org/uniprot/Q751N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR004C ^@ http://purl.uniprot.org/uniprot/Q75DL4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL053C ^@ http://purl.uniprot.org/uniprot/Q75AI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ABL005C ^@ http://purl.uniprot.org/uniprot/Q75DM2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AEL303C ^@ http://purl.uniprot.org/uniprot/Q758Q6 ^@ Function|||Similarity ^@ Belongs to the SPG4 family.|||Stationary phase-essential protein not required for growth on nonfermentable carbon sources. http://togogenome.org/gene/284811:AGOS_ADR018C ^@ http://purl.uniprot.org/uniprot/Q75AA0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PAN1 family.|||Cell membrane|||Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).|||Component of the PAN1 actin cytoskeleton-regulatory complex.|||Endosome membrane|||actin patch http://togogenome.org/gene/284811:AGOS_AGR082C ^@ http://purl.uniprot.org/uniprot/Q74ZX6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GEP5 family.|||Essential for respiratory growth and required for maintenance of mtDNA. Required for cell survival in the absence of prohibitins (By similarity).|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ABR084W ^@ http://purl.uniprot.org/uniprot/Q75DE3 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/284811:AGOS_AFL081W ^@ http://purl.uniprot.org/uniprot/Q755A6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR253W ^@ http://purl.uniprot.org/uniprot/Q753S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ACL197W ^@ http://purl.uniprot.org/uniprot/Q75CW3 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/284811:AGOS_AER376W ^@ http://purl.uniprot.org/uniprot/Q755Z1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRT14 family.|||Involved in ribosome biogenesis, probably through modulation of rDNA transcription.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAR059C ^@ http://purl.uniprot.org/uniprot/Q00063 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/284811:AGOS_AFR386C ^@ http://purl.uniprot.org/uniprot/Q753D0 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/284811:AGOS_AAR165W ^@ http://purl.uniprot.org/uniprot/Q75EB2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FIT family. Fungal FIT2B/SCS3 subfamily.|||Endoplasmic reticulum membrane|||Fatty acyl-coenzyme A (CoA) diphosphatase that hydrolyzes fatty acyl-CoA to yield acyl-4'-phosphopantetheine and adenosine 3',5'-bisphosphate. Preferentially hydrolyzes unsaturated long-chain acyl-CoA substrates in the endoplasmic reticulum (ER) lumen. This catalytic activity is required for maintaining ER structure and for lipid droplets (LDs) biogenesis, which are lipid storage organelles involved in maintaining lipid and energy homeostasis. May directly bind to diacylglycerol (DAGs) and triacylglycerol, which is also important for LD biogenesis. May support directional budding of nacent LDs from the ER into the cytosol by reducing DAG levels at sites of LD formation. May play a role in the regulation of cell morphology and cytoskeletal organization. Involved in phospholipid biosynthesis.|||Membrane http://togogenome.org/gene/284811:AGOS_ABL171W ^@ http://purl.uniprot.org/uniprot/Q75E41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE4 family.|||May be involved in intracellular vesicle transport.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR662C ^@ http://purl.uniprot.org/uniprot/Q752B3 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/284811:AGOS_ADR168C ^@ http://purl.uniprot.org/uniprot/Q759V4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MSH3 subfamily.|||Component of the post-replicative DNA mismatch repair system (MMR). Heterodimerizes with MSH2 to form MutS beta, which binds to DNA mismatches thereby initiating DNA repair. MSH3 provides substrate-binding and substrate specificity to the complex. When bound, the MutS beta heterodimer bends the DNA helix and shields approximately 20 base pairs. Acts mainly to repair insertion-deletion loops (IDLs) from 2 to 13 nucleotides in size, but can also repair base-base and single insertion-deletion mismatches that occur during replication. After mismatch binding, forms a ternary complex with the MutL alpha heterodimer, which is thought to be responsible for directing the downstream MMR events, including strand discrimination, excision, and resynthesis. ATP binding and hydrolysis play a pivotal role in mismatch repair functions (By similarity).|||Heterodimer consisting of MSH2-MSH3 (MutS beta). Forms a ternary complex with MutL alpha (MLH1-PMS1) (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR110C ^@ http://purl.uniprot.org/uniprot/Q75A17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. TRM10 family.|||Cytoplasm|||Monomer.|||Nucleus|||S-adenosyl-L-methionine-dependent guanine N(1)-methyltransferase that catalyzes the formation of N(1)-methylguanine at position 9 (m1G9) in cytoplasmic tRNA. http://togogenome.org/gene/284811:AGOS_AGR153C ^@ http://purl.uniprot.org/uniprot/Q74ZP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking. http://togogenome.org/gene/284811:AGOS_AFR478W ^@ http://purl.uniprot.org/uniprot/Q752U5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/284811:AGOS_AAR013W ^@ http://purl.uniprot.org/uniprot/P62512 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MIM1 family.|||Mitochondrion outer membrane|||Required for the assembly of the TOM (translocase of outer membrane) receptor complex, which is responsible for the recognition and translocation of cytosolically synthesized mitochondrial preproteins. http://togogenome.org/gene/284811:AGOS_AEL119W ^@ http://purl.uniprot.org/uniprot/Q757X9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/284811:AGOS_ADL348W ^@ http://purl.uniprot.org/uniprot/Q75BB5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane|||Essential oxidoreductase that oxidizes proteins in the endoplasmic reticulum to produce disulfide bonds. Acts by oxidizing directly PDI1 isomerase through a direct disulfide exchange. Does not act as a direct oxidant of folding substrate, but relies on PDI1 to transfer oxidizing equivalent. Does not oxidize all pdi related proteins, suggesting that it can discriminate between PDI1 and related proteins. Its reoxidation probably involves electron transfer to molecular oxygen via FAD. Acts independently of glutathione. May be responsible for a significant proportion of reactive oxygen species (ROS) in the cell, thereby being a source of oxidative stress (By similarity).|||May function both as a monomer and a homodimer. http://togogenome.org/gene/284811:AGOS_AFR033C ^@ http://purl.uniprot.org/uniprot/Q754N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHS7 family.|||Chaperone required for the export of the chitin synthase CHS3 from the endoplasmic reticulum.|||Endoplasmic reticulum membrane|||Interacts with CHS3. http://togogenome.org/gene/284811:AGOS_ADL114C ^@ http://purl.uniprot.org/uniprot/Q75AN6 ^@ Similarity ^@ Belongs to the TPA1 family. http://togogenome.org/gene/284811:AGOS_ACR219W ^@ http://purl.uniprot.org/uniprot/Q75BQ2 ^@ Similarity|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284811:AGOS_AGL133W ^@ http://purl.uniprot.org/uniprot/Q750S2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus|||Plays a structural role in chromatin. Probably involved in sister chromatid cohesion, possibly by interacting with the cohesin complex (By similarity). http://togogenome.org/gene/284811:AGOS_AEL336W ^@ http://purl.uniprot.org/uniprot/Q758T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SWC3 family.|||Component of the SWR1 chromatin remodeling complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. Involved in chromosome stability (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL074W ^@ http://purl.uniprot.org/uniprot/Q750N0 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/284811:AGOS_ACL117W ^@ http://purl.uniprot.org/uniprot/Q75CN6 ^@ Similarity ^@ Belongs to the IlvD/Edd family. http://togogenome.org/gene/284811:AGOS_AEL321C ^@ http://purl.uniprot.org/uniprot/Q758S3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Component of the mitochondrial large ribosomal subunit. Mature mitochondrial ribosomes consist of a small (37S) and a large (54S) subunit. The 37S subunit contains at least 33 different proteins and 1 molecule of RNA (15S). The 54S subunit contains at least 45 different proteins and 1 molecule of RNA (21S) (By similarity).|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR023W ^@ http://purl.uniprot.org/uniprot/Q754P9 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/284811:AGOS_ADL264C ^@ http://purl.uniprot.org/uniprot/Q75B41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR334W ^@ http://purl.uniprot.org/uniprot/Q759E3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR040C ^@ http://purl.uniprot.org/uniprot/Q750B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAR191C ^@ http://purl.uniprot.org/uniprot/Q75E89 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/284811:AGOS_AFR353W ^@ http://purl.uniprot.org/uniprot/Q753G1 ^@ Similarity ^@ Belongs to the Cdt1 family. http://togogenome.org/gene/284811:AGOS_ADR331C ^@ http://purl.uniprot.org/uniprot/Q759E6 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/284811:AGOS_AEL202C ^@ http://purl.uniprot.org/uniprot/Q758G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the palH/RIM21 family.|||Cell membrane|||Required for the proteolytic cleavage of the transcription factor RIM101 in response to alkaline ambient pH. http://togogenome.org/gene/284811:AGOS_ABR226W ^@ http://purl.uniprot.org/uniprot/Q75CZ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FYV7 family.|||Involved in the processing of the 20S pre-rRNA.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR189C ^@ http://purl.uniprot.org/uniprot/Q753Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Clp1 family. NOL9/GRC3 subfamily.|||Polynucleotide 5'-kinase involved in rRNA processing.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL232W ^@ http://purl.uniprot.org/uniprot/Q75B09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER330W ^@ http://purl.uniprot.org/uniprot/Q756D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADL211C ^@ http://purl.uniprot.org/uniprot/Q75AY1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS23 family.|||Component of the mitochondrial small ribosomal subunit.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL125C ^@ http://purl.uniprot.org/uniprot/Q750R7 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autopalmitoylated.|||Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Endoplasmic reticulum membrane|||Interacts with ERF4.|||The DHHC domain is required for palmitoyltransferase activity.|||The ERF2-ERF4 complex is a palmitoyltransferase specific for Ras proteins. http://togogenome.org/gene/284811:AGOS_ADR106W ^@ http://purl.uniprot.org/uniprot/Q75AG7 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/284811:AGOS_AGR276W ^@ http://purl.uniprot.org/uniprot/Q74ZC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL145W ^@ http://purl.uniprot.org/uniprot/Q755G8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/284811:AGOS_ADL125C ^@ http://purl.uniprot.org/uniprot/Q75AP5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/284811:AGOS_AAL100C ^@ http://purl.uniprot.org/uniprot/Q75F28 ^@ Similarity ^@ Belongs to the TMA16 family. http://togogenome.org/gene/284811:AGOS_AEL191C ^@ http://purl.uniprot.org/uniprot/Q758F3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL344W ^@ http://purl.uniprot.org/uniprot/Q758U6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR229W ^@ http://purl.uniprot.org/uniprot/Q75BP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit J family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADR113W ^@ http://purl.uniprot.org/uniprot/Q75A11 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/284811:AGOS_ACR286C ^@ http://purl.uniprot.org/uniprot/Q75BI5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER100C ^@ http://purl.uniprot.org/uniprot/Q757B3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR258W ^@ http://purl.uniprot.org/uniprot/Q9C1M7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dynein heavy chain family.|||Consists of at least two heavy chains and a number of intermediate and light chains.|||Cytoplasmic dynein acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP. Required to maintain uniform nuclear distribution in hyphae. May play an important role in the proper orientation of the mitotic spindle into the budding daughter cell yeast. Probably required for normal progression of the cell cycle.|||Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AAL150W ^@ http://purl.uniprot.org/uniprot/Q75F78 ^@ Similarity ^@ Belongs to the HGH1 family. http://togogenome.org/gene/284811:AGOS_ACR187W ^@ http://purl.uniprot.org/uniprot/Q75BT4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AER169C ^@ http://purl.uniprot.org/uniprot/Q756T4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/284811:AGOS_AER299C ^@ http://purl.uniprot.org/uniprot/Q756G7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR166C ^@ http://purl.uniprot.org/uniprot/Q754A6 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284811:AGOS_AGL242C ^@ http://purl.uniprot.org/uniprot/Q751E8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Interacts with a number of cyclins.|||When phosphate concentrations are high it phosphorylates the PHO4 transcription factor thus establishing repression. http://togogenome.org/gene/284811:AGOS_ADL325C ^@ http://purl.uniprot.org/uniprot/Q75B95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRR1 family.|||Involved in mRNA splicing. Required for snRNA accumulation and manufacture of snRNPs (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ABL116C ^@ http://purl.uniprot.org/uniprot/Q75DY9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL072C ^@ http://purl.uniprot.org/uniprot/Q75AJ9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/284811:AGOS_ACL150W ^@ http://purl.uniprot.org/uniprot/Q75CR9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR087C ^@ http://purl.uniprot.org/uniprot/Q75A33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family. PPIase D subfamily.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/284811:AGOS_ABL026W ^@ http://purl.uniprot.org/uniprot/Q75DP3 ^@ Similarity ^@ Belongs to the SSH4 family. http://togogenome.org/gene/284811:AGOS_AAL104C ^@ http://purl.uniprot.org/uniprot/Q75F32 ^@ Similarity ^@ Belongs to the NXF family. http://togogenome.org/gene/284811:AGOS_AFR173W ^@ http://purl.uniprot.org/uniprot/Q753Z9 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/284811:AGOS_AGR079W ^@ http://purl.uniprot.org/uniprot/Q74ZX9 ^@ Similarity ^@ Belongs to the eIF2D family. http://togogenome.org/gene/284811:AGOS_ADR184W ^@ http://purl.uniprot.org/uniprot/Q759T9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family. PreP subfamily.|||Binds 1 zinc ion per subunit.|||Degrades mitochondrial transit peptides after their cleavage in the intermembrane space or in the matrix, and presequence peptides; clearance of these peptides is required to keep the presequence processing machinery running (By similarity). Preferentially cleaves the N-terminal side of paired basic amino acid residues (By similarity). Also degrades other unstructured peptides (By similarity). May function as an ATP-dependent peptidase as opposed to a metalloendopeptidase (By similarity).|||Mitochondrion intermembrane space|||Mitochondrion matrix|||Monomer and homodimer; homodimerization is induced by binding of the substrate. http://togogenome.org/gene/284811:AGOS_AFL102W ^@ http://purl.uniprot.org/uniprot/Q755C5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in mitochondrial RNA metabolism. Required for maintenance of mitochondrial DNA (By similarity).|||Belongs to the DEAD box helicase family. MRH4 subfamily.|||Mitochondrion|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AFR668W ^@ http://purl.uniprot.org/uniprot/Q752A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR075W ^@ http://purl.uniprot.org/uniprot/Q75A44 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB17 family.|||Cytoplasm|||May be involved in protein-linked oligosaccharide phosphorylation. http://togogenome.org/gene/284811:AGOS_AFL188C ^@ http://purl.uniprot.org/uniprot/Q755K5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CHEK2 subfamily. http://togogenome.org/gene/284811:AGOS_AFL089C ^@ http://purl.uniprot.org/uniprot/Q755B4 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/284811:AGOS_ACR129W ^@ http://purl.uniprot.org/uniprot/Q75BZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Mitochondrion|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of mitochondrial acyl-carrier-protein. http://togogenome.org/gene/284811:AGOS_AFR179C ^@ http://purl.uniprot.org/uniprot/Q753Z3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/284811:AGOS_ABL136C ^@ http://purl.uniprot.org/uniprot/Q75E09 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/284811:AGOS_AFL091W ^@ http://purl.uniprot.org/uniprot/Q755B6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_ABR053C ^@ http://purl.uniprot.org/uniprot/Q75DH3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/284811:AGOS_AAR099W ^@ http://purl.uniprot.org/uniprot/Q75EI0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_ADL266C ^@ http://purl.uniprot.org/uniprot/Q75B43 ^@ Function|||Similarity ^@ Belongs to the peptidase C14B family.|||Involved in cell death (apoptosis). http://togogenome.org/gene/284811:AGOS_AFL035C ^@ http://purl.uniprot.org/uniprot/Q754V6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/284811:AGOS_AAR108C ^@ http://purl.uniprot.org/uniprot/Q75EH1 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/284811:AGOS_ADL139W ^@ http://purl.uniprot.org/uniprot/Q75AQ9 ^@ Similarity ^@ Belongs to the KNR4/SMI1 family. http://togogenome.org/gene/284811:AGOS_AFR394W ^@ http://purl.uniprot.org/uniprot/Q753C2 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284811:AGOS_ACL066C ^@ http://purl.uniprot.org/uniprot/Q75CI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG10 family.|||E2-like enzyme required for the cytoplasm to vacuole transport (Cvt), autophagy and nucleophagy. Acts as an E2-like enzyme that catalyzes the conjugation of ATG12 to ATG5. ATG12 conjugation to ATG5 is required for proper localization of ATG8 to the preautophagosomal structure (PAS). Likely serves as an ATG5-recognition molecule (By similarity).|||Forms homooligomers.|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_AFL174C ^@ http://purl.uniprot.org/uniprot/Q755J7 ^@ Function|||Similarity ^@ Belongs to the cyclin family.|||G1/S-specific cyclin essential for the control of the cell cycle at the G1/S (start) transition. http://togogenome.org/gene/284811:AGOS_AGL201C ^@ http://purl.uniprot.org/uniprot/Q750Y8 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AFR719W ^@ http://purl.uniprot.org/uniprot/Q751V6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MGR1 family.|||Component of the mitochondrial inner membrane i-AAA protease complex required for mitochondrial inner membrane protein turnover.|||Component of the mitochondrial inner membrane i-AAA protease complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER112C ^@ http://purl.uniprot.org/uniprot/Q757A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AAL084W ^@ http://purl.uniprot.org/uniprot/Q75F12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR228W ^@ http://purl.uniprot.org/uniprot/Q753U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ACR198W ^@ http://purl.uniprot.org/uniprot/Q75BS3 ^@ Function|||Similarity ^@ Belongs to the PNP/MTAP phosphorylase family.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. http://togogenome.org/gene/284811:AGOS_AGR170C ^@ http://purl.uniprot.org/uniprot/Q74ZM8 ^@ Similarity ^@ Belongs to the SLA1 family. http://togogenome.org/gene/284811:AGOS_ACR228C ^@ http://purl.uniprot.org/uniprot/Q8J1G4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. BimC subfamily.|||Required for assembly of the mitotic spindle. Interacts with spindle microtubules to produce an outwardly directed force acting upon the poles. Following spindle assembly, CIN8 and KIP1 apparently act to oppose a force that draws separated poles back together. This force seems to be mediate by KAR3 (By similarity).|||spindle http://togogenome.org/gene/284811:AGOS_ADR162W ^@ http://purl.uniprot.org/uniprot/Q759W0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Catalyzes C14-demethylation of lanosterol which is critical for ergosterol biosynthesis. It transforms lanosterol into 4,4'-dimethyl cholesta-8,14,24-triene-3-beta-ol (By similarity).|||Membrane http://togogenome.org/gene/284811:AGOS_ABR022C ^@ http://purl.uniprot.org/uniprot/Q75DS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR217C ^@ http://purl.uniprot.org/uniprot/Q75BQ4 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/284811:AGOS_AAR126W ^@ http://purl.uniprot.org/uniprot/Q75EF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP17 family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR658W ^@ http://purl.uniprot.org/uniprot/Q752B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL088W ^@ http://purl.uniprot.org/uniprot/Q75AL5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the JHDM1 histone demethylase family.|||Binds 1 Fe(2+) ion per subunit.|||Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code.|||Nucleus|||The JmjC domain mediates the demethylation activity. http://togogenome.org/gene/284811:AGOS_ADR299W ^@ http://purl.uniprot.org/uniprot/Q759H9 ^@ Function|||Similarity ^@ Belongs to the peptidase C13 family.|||Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. http://togogenome.org/gene/284811:AGOS_AGL349C ^@ http://purl.uniprot.org/uniprot/Q751N9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL044W ^@ http://purl.uniprot.org/uniprot/Q75CG3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AEL249C ^@ http://purl.uniprot.org/uniprot/Q758L0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI family.|||Homodimer.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.|||cytosol http://togogenome.org/gene/284811:AGOS_ACL202W ^@ http://purl.uniprot.org/uniprot/Q75CW8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 76 family. http://togogenome.org/gene/284811:AGOS_ADR109W ^@ http://purl.uniprot.org/uniprot/Q75A18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase inhibitor family.|||Forms a one-to-one complex with ATPase to inhibit the enzyme activity completely.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL334W ^@ http://purl.uniprot.org/uniprot/Q751N1 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/284811:AGOS_AFR151C ^@ http://purl.uniprot.org/uniprot/Q754B9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sterol desaturase family.|||Catalyzes the introduction of a C-5 double bond in the B ring of ergosterol. May contribute to the regulation of ergosterol biosynthesis.|||Endoplasmic reticulum membrane|||The histidine box domains may contain the active site and/or be involved in metal ion binding. http://togogenome.org/gene/284811:AGOS_AFR635C ^@ http://purl.uniprot.org/uniprot/Q752E1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ACR126W ^@ http://purl.uniprot.org/uniprot/Q75BZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP53 family.|||May play a role in ribosome biogenesis.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_AFL205C ^@ http://purl.uniprot.org/uniprot/Q755L9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR257C ^@ http://purl.uniprot.org/uniprot/Q759L9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/284811:AGOS_AFR686C ^@ http://purl.uniprot.org/uniprot/Q751Y9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/284811:AGOS_AGR159C ^@ http://purl.uniprot.org/uniprot/Q74ZN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR192CA ^@ http://purl.uniprot.org/uniprot/Q75D30 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum membrane|||Interacts with GPI2, suggesting that it is a component of the GPI-GnT complex, probably composed of GPI1, GPI2, GPI3, GPI15, and ERI1.|||Probable component of the GPI-GlcNAc transferase (GPI-GnT) complex in the endoplasmic reticulum, a complex that catalyzes transfer of GlcNAc from UDP-GlcNAc to an acceptor phosphatidylinositol, the first step in the production of GPI-anchors for cell surface proteins. http://togogenome.org/gene/284811:AGOS_AFR377C ^@ http://purl.uniprot.org/uniprot/Q753D9 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Serine/threonine-protein kinase. http://togogenome.org/gene/284811:AGOS_AGL067W ^@ http://purl.uniprot.org/uniprot/Q750M4 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/284811:AGOS_ABR105C ^@ http://purl.uniprot.org/uniprot/Q75DC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AFR553C ^@ http://purl.uniprot.org/uniprot/Q752M1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL098W ^@ http://purl.uniprot.org/uniprot/Q750P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284811:AGOS_ADL212W ^@ http://purl.uniprot.org/uniprot/Q75AY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. METTL21 family. EFM6 subfamily.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha. http://togogenome.org/gene/284811:AGOS_AER413C ^@ http://purl.uniprot.org/uniprot/Q755V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR566C ^@ http://purl.uniprot.org/uniprot/Q752K8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284811:AGOS_AAL031W ^@ http://purl.uniprot.org/uniprot/Q75EV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FYV6 family.|||Involved in telomere length regulation and promotes fully efficient non-homologous end-joining (NHEJ) by a mechanism activated in postdiauxic/stationary phase.|||Nucleus|||telomere http://togogenome.org/gene/284811:AGOS_ACR054C ^@ http://purl.uniprot.org/uniprot/Q75C62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||May mediate the reduction of outer membrane cytochrome b5.|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_ADR187W ^@ http://purl.uniprot.org/uniprot/Q759T6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPT5 family.|||Component of the SPT4-SPT5 complex. Interacts with RNA polymerase II (By similarity).|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene (By similarity). http://togogenome.org/gene/284811:AGOS_AAR138C ^@ http://purl.uniprot.org/uniprot/Q75EE3 ^@ Similarity ^@ Belongs to the SGT1 family. http://togogenome.org/gene/284811:AGOS_AFL043C ^@ http://purl.uniprot.org/uniprot/Q754W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADR022W ^@ http://purl.uniprot.org/uniprot/Q75A96 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACL092C ^@ http://purl.uniprot.org/uniprot/Q75CL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARPC4 family.|||Functions as actin-binding component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks. Seems to contact the mother actin filament.|||actin patch http://togogenome.org/gene/284811:AGOS_ADL278C ^@ http://purl.uniprot.org/uniprot/Q75B55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. GEP3 subfamily.|||May be involved in the mitochondrial lipid metabolism.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR229C ^@ http://purl.uniprot.org/uniprot/Q753U6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR034W ^@ http://purl.uniprot.org/uniprot/Q75C82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly. Required for cell wall integrity (By similarity). http://togogenome.org/gene/284811:AGOS_ADL206W ^@ http://purl.uniprot.org/uniprot/Q75AX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL336W ^@ http://purl.uniprot.org/uniprot/Q751N3 ^@ Function|||Similarity ^@ Belongs to the peptidase T1A family.|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity. http://togogenome.org/gene/284811:AGOS_AER157C ^@ http://purl.uniprot.org/uniprot/Q756U5 ^@ Similarity ^@ Belongs to the peptidase M28 family. M28B subfamily. http://togogenome.org/gene/284811:AGOS_AEL190W ^@ http://purl.uniprot.org/uniprot/Q758F2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chitin synthase family.|||Cell membrane|||Membrane|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/284811:AGOS_AEL196W ^@ http://purl.uniprot.org/uniprot/Q758F8 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/284811:AGOS_ABR059W ^@ http://purl.uniprot.org/uniprot/Q75DG7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_AAL007C ^@ http://purl.uniprot.org/uniprot/Q75EU2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/284811:AGOS_AGR099C ^@ http://purl.uniprot.org/uniprot/Q74ZU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AAL173C ^@ http://purl.uniprot.org/uniprot/Q75F89 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER097C ^@ http://purl.uniprot.org/uniprot/Q757B6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster facilitates the reduction of the catalytic iron-sulfur cluster in the DPH1 subunit.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1 (By similarity). Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit (By similarity). http://togogenome.org/gene/284811:AGOS_AFR613C ^@ http://purl.uniprot.org/uniprot/Q752G3 ^@ Similarity ^@ Belongs to the SecY/SEC61-alpha family. http://togogenome.org/gene/284811:AGOS_ADL129W ^@ http://purl.uniprot.org/uniprot/Q75AP9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/284811:AGOS_AGR107C ^@ http://purl.uniprot.org/uniprot/Q74ZU1 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/284811:AGOS_AFR244C ^@ http://purl.uniprot.org/uniprot/Q753T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHE10 family.|||Component of the mitochondria-localized RNase mitochondrial RNA-processing (RNase MRP) composed of one single RNA encoded by the NME1 gene and at least 31 proteins. Absent in the nucleus-localized RNase MRP (NuMRP).|||Involved in spore wall assembly. May be a component of the mitochondrial RNase MRP (MtMRP), a ribonucleoprotein endoribonuclease involved in the cleaving RNA transcripts to generate primers for DNA replication in mitochondria.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADL086C ^@ http://purl.uniprot.org/uniprot/Q75AL3 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/284811:AGOS_AAL121C ^@ http://purl.uniprot.org/uniprot/Q75F49 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NADPH--cytochrome P450 reductase family.|||Binds 1 FAD per monomer.|||Binds 1 FMN per monomer.|||Cell membrane|||Endoplasmic reticulum membrane|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion outer membrane|||This enzyme is required for electron transfer from NADP to cytochrome P450 in microsomes. It can also provide electron transfer to heme oxygenase and cytochrome B5. Involved in ergosterol biosynthesis. http://togogenome.org/gene/284811:AGOS_ACR026W ^@ http://purl.uniprot.org/uniprot/Q75C90 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. http://togogenome.org/gene/284811:AGOS_ADL351W ^@ http://purl.uniprot.org/uniprot/Q75BB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AER347W ^@ http://purl.uniprot.org/uniprot/Q756C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_AFR417W ^@ http://purl.uniprot.org/uniprot/Q753A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR711C ^@ http://purl.uniprot.org/uniprot/Q751W4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR708W ^@ http://purl.uniprot.org/uniprot/Q751W7 ^@ Cofactor|||Similarity ^@ Belongs to the MsrB Met sulfoxide reductase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_ADL309W ^@ http://purl.uniprot.org/uniprot/Q75B81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/284811:AGOS_ADR390C ^@ http://purl.uniprot.org/uniprot/Q758Y7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasm|||Golgi apparatus membrane|||Prevacuolar compartment membrane|||Required for retention of late Golgi membrane proteins. Component of the retrieval machinery that functions by direct interaction with the cytosolic tails of certain TGN membrane proteins during the sorting/budding process at the prevacuolar compartment. Binds phosphatidylinositol 3-phosphate (PtdIns(P3)) (By similarity).|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. http://togogenome.org/gene/284811:AGOS_AFR351C ^@ http://purl.uniprot.org/uniprot/Q753R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGR387C ^@ http://purl.uniprot.org/uniprot/Q74Z19 ^@ Similarity ^@ Belongs to the frataxin family. http://togogenome.org/gene/284811:AGOS_AFR231W ^@ http://purl.uniprot.org/uniprot/Q753U4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC family.|||Cytoplasm|||mRNA-binding protein which stimulates mRNA decapping. http://togogenome.org/gene/284811:AGOS_AER093C ^@ http://purl.uniprot.org/uniprot/Q757C0 ^@ Similarity ^@ Belongs to the Mo25 family. http://togogenome.org/gene/284811:AGOS_ADR350W ^@ http://purl.uniprot.org/uniprot/Q759C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_AER242C ^@ http://purl.uniprot.org/uniprot/Q756L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BLOC1S4 family.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1), a complex that is involved in endosomal cargo sorting.|||Component of the biogenesis of lysosome-related organelles complex-1 (BLOC-1).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGR289C ^@ http://purl.uniprot.org/uniprot/Q74ZB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MEC3 family.|||Component of the checkpoint clamp complex composed of DDC1, MEC3 and RAD17.|||Component of the checkpoint clamp complex involved in the surveillance mechanism that allows the DNA repair pathways to act to restore the integrity of the DNA prior to DNA synthesis or separation of the replicated chromosomes.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR322C ^@ http://purl.uniprot.org/uniprot/Q753J0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACL168C ^@ http://purl.uniprot.org/uniprot/Q75CT7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the profilin family.|||Binds to actin and affects the structure of the cytoskeleton. At high concentrations, profilin prevents the polymerization of actin, whereas it enhances it at low concentrations.|||Occurs in many kinds of cells as a complex with monomeric actin in a 1:1 ratio. http://togogenome.org/gene/284811:AGOS_ADR054C ^@ http://purl.uniprot.org/uniprot/Q75A64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EXO5 family.|||Binds 1 [4Fe-4S] cluster.|||Mitochondrion|||Monomer.|||Single strand DNA specific 5' exonuclease involved in mitochondrial DNA replication and recombination. Releases dinucleotides as main products of catalysis. Has the capacity to slide across 5'double-stranded DNA or 5'RNA sequences and resumes cutting two nucleotides downstream of the double-stranded-to-single-stranded junction or RNA-to-DNA junction, respectively (By similarity). http://togogenome.org/gene/284811:AGOS_ADL041C ^@ http://purl.uniprot.org/uniprot/Q75AF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COX19 family.|||Cytoplasm|||Mitochondrion intermembrane space|||Required for the assembly of mitochondrial cytochrome c oxidase. http://togogenome.org/gene/284811:AGOS_AFL176C ^@ http://purl.uniprot.org/uniprot/Q755J9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS27 family.|||Both IUM domains are necessary for efficient binding to ubiquitin.|||Component of the ESCRT-0 complex composed of HSE1 and VPS27.|||Component of the ESCRT-0 complex which is the sorting receptor for ubiquitinated cargo proteins at the multivesicular body (MVB) and recruits ESCRT-I to the MVB outer membrane.|||Endosome membrane|||The FYVE domain is involved in the binding to phosphatidylinositol 3-phosphate (PtdIns(3)P) which is required for the association to endosomal membranes. http://togogenome.org/gene/284811:AGOS_AAR035C ^@ http://purl.uniprot.org/uniprot/Q75EP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase PH family.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL190W ^@ http://purl.uniprot.org/uniprot/Q750X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AGR199W ^@ http://purl.uniprot.org/uniprot/Q74ZK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR513C ^@ http://purl.uniprot.org/uniprot/Q752R0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL127W ^@ http://purl.uniprot.org/uniprot/Q75F55 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_AAL145W ^@ http://purl.uniprot.org/uniprot/Q75F73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCR10/QCR9 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein, 2 core protein subunits, and additional low-molecular weight protein subunits.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR296C ^@ http://purl.uniprot.org/uniprot/Q759H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-3 family.|||Involved in peroxisome biosynthesis.|||Peroxisome membrane http://togogenome.org/gene/284811:AGOS_AGR317C ^@ http://purl.uniprot.org/uniprot/Q74Z86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR010C ^@ http://purl.uniprot.org/uniprot/Q75AA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with ribosomal complexes.|||Belongs to the TMA20 family.|||Cytoplasm|||Involved in translation. http://togogenome.org/gene/284811:AGOS_AFR220W ^@ http://purl.uniprot.org/uniprot/Q753V5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Cytoplasm|||Nucleus|||Probable helicase, member of the UBC2/RAD6 epistasis group. Functions with DNA repair protein RAD18 in error-free postreplication DNA repair. Involved in the maintenance of wild-type rates of instability of simple repetitive sequences such as poly(GT) repeats. Seems to be involved in maintaining a balance which acts in favor of error-prone non-homologous joining during DNA double-strand breaks repairs (By similarity). http://togogenome.org/gene/284811:AGOS_AGL172W ^@ http://purl.uniprot.org/uniprot/Q750W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal Na(+)/H(+) exchanger family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER191W ^@ http://purl.uniprot.org/uniprot/Q756R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR092C ^@ http://purl.uniprot.org/uniprot/Q75DD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL264W ^@ http://purl.uniprot.org/uniprot/Q751H0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/284811:AGOS_AER027W ^@ http://purl.uniprot.org/uniprot/Q757I6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Belongs to the DEAD box helicase family. DDX24/MAK5 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER339C ^@ http://purl.uniprot.org/uniprot/Q756C8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABL056C ^@ http://purl.uniprot.org/uniprot/Q75DT2 ^@ Function|||Similarity ^@ Belongs to the glucose-6-phosphate 1-epimerase family.|||Catalyzes the interconversion between the alpha and beta anomers from at least three hexose 6-phosphate sugars (Glc6P, Gal6P, and Man6P). http://togogenome.org/gene/284811:AGOS_AER416C ^@ http://purl.uniprot.org/uniprot/Q755V2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the END3 family.|||Cell membrane|||Component of the PAN1 actin cytoskeleton-regulatory complex required for the internalization of endosomes during actin-coupled endocytosis. The complex links the site of endocytosis to the cell membrane-associated actin cytoskeleton. Mediates uptake of external molecules and vacuolar degradation of plasma membrane proteins. Plays a role in the proper organization of the cell membrane-associated actin cytoskeleton and promotes its destabilization (By similarity).|||Component of the PAN1 actin cytoskeleton-regulatory complex.|||Endosome membrane|||actin patch http://togogenome.org/gene/284811:AGOS_AFR190C ^@ http://purl.uniprot.org/uniprot/Q753Y2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by C-terminal proteolytic cleavage by signaling protease (probably RIM13) at neutral to alkaline ambient pH.|||Belongs to the pacC/RIM101 family.|||Binds to DNA. Interacts with RIM20, which binds to the two YPX[LI] motifs and is required for proteolytic processing (By similarity).|||Cytoplasm|||Nucleus|||Transcription factor that mediates regulation of both acid- and alkaline-expressed genes in response to ambient pH. At alkaline ambient pH, activates transcription of alkaline-expressed genes (including palB/RIM101 itself) and represses transcription of acid-expressed genes (By similarity). http://togogenome.org/gene/284811:AGOS_AEL081W ^@ http://purl.uniprot.org/uniprot/Q757U3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily.|||Catalyzes the NADPH-dependent reduction of trans-2-enoyl thioesters in mitochondrial fatty acid synthesis (fatty acid synthesis type II). Fatty acid chain elongation in mitochondria uses acyl carrier protein (ACP) as an acyl group carrier, but the enzyme accepts both ACP and CoA thioesters as substrates in vitro. Required for respiration and the maintenance of the mitochondrial compartment.|||Homodimer.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_AER312W ^@ http://purl.uniprot.org/uniprot/Q756F9 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/284811:AGOS_AAL119W ^@ http://purl.uniprot.org/uniprot/Q75F47 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PROPPIN family.|||Component of the PI(3,5)P2 regulatory complex.|||Endosome membrane|||Preautophagosomal structure membrane|||The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway, for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium, and for its recruitment to and dissociation from the PAS under starvation conditions.|||The N-terminus might form a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2), leading to the association of the protein to the membrane.|||The PI(3,5)P2 regulatory complex regulates both the synthesis and turnover of phosphatidylinositol 3,5-bisphosphate (PtdIns(3,5)P2). Necessary for proper vacuole morphology. Plays an important role in osmotically-induced vacuole fragmentation. Required for cytoplasm to vacuole transport (Cvt) vesicle formation, pexophagy and starvation-induced autophagy. Involved in correct ATG9 trafficking to the pre-autophagosomal structure. Might also be involved in premeiotic DNA replication (By similarity).|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AGL202W ^@ http://purl.uniprot.org/uniprot/Q750Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ALG14 family.|||Endoplasmic reticulum membrane|||Heterodimer with ALG13 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway. Anchors the catalytic subunit ALG13 to the ER (By similarity).|||Nucleus membrane http://togogenome.org/gene/284811:AGOS_ADR166W ^@ http://purl.uniprot.org/uniprot/Q759V6 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/284811:AGOS_ADR240C ^@ http://purl.uniprot.org/uniprot/Q759N5 ^@ Function|||Similarity ^@ Belongs to the cytochrome c oxidase subunit 6B family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. http://togogenome.org/gene/284811:AGOS_AFR175C ^@ http://purl.uniprot.org/uniprot/Q753Z7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RPAP2 family.|||Nucleus|||Putative RNA polymerase II subunit B1 C-terminal domain (CTD) phosphatase involved in RNA polymerase II transcription regulation. http://togogenome.org/gene/284811:AGOS_AER289W ^@ http://purl.uniprot.org/uniprot/Q756H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.|||Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates (By similarity). http://togogenome.org/gene/284811:AGOS_AFR477C ^@ http://purl.uniprot.org/uniprot/Q752U6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/284811:AGOS_AGR254C ^@ http://purl.uniprot.org/uniprot/Q74ZE5 ^@ Similarity ^@ Belongs to the taffazin family. http://togogenome.org/gene/284811:AGOS_AFR388W ^@ http://purl.uniprot.org/uniprot/Q753C8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR002C ^@ http://purl.uniprot.org/uniprot/Q754S0 ^@ Similarity ^@ Belongs to the VPS8 family. http://togogenome.org/gene/284811:AGOS_ADL268C ^@ http://purl.uniprot.org/uniprot/Q75B45 ^@ Similarity ^@ Belongs to the IPP isomerase type 1 family. http://togogenome.org/gene/284811:AGOS_AAR149W ^@ http://purl.uniprot.org/uniprot/Q75EC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER201C ^@ http://purl.uniprot.org/uniprot/Q756Q3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NPC2 family.|||Catalyzes the intermembrane transfer of phosphatidylglycerol and phosphatidylinositol.|||Monomer. http://togogenome.org/gene/284811:AGOS_AGR322W ^@ http://purl.uniprot.org/uniprot/Q74ZF6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfate adenylyltransferase family.|||Catalyzes the first intracellular reaction of sulfate assimilation, forming adenosine-5'-phosphosulfate (APS) from inorganic sulfate and ATP. Plays an important role in sulfate activation as a component of the biosynthesis pathway of sulfur-containing amino acids.|||Cytoplasm|||Homohexamer. Dimer of trimers.|||The oligomerization domain is distantly related to APS kinases, but it is not functional and does not bind APS. It is required for oligomerization of the enzyme, although the oligomerization state has no effect on the catalytic activity of the enzyme. http://togogenome.org/gene/284811:AGOS_AER009C ^@ http://purl.uniprot.org/uniprot/Q757K3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MAF1 family.|||Mediator of diverse signals that repress RNA polymerase III transcription. Inhibits the de novo assembly of TFIIIB onto DNA (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR234C ^@ http://purl.uniprot.org/uniprot/Q75BN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/284811:AGOS_AFL101C ^@ http://purl.uniprot.org/uniprot/Q755C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||Nucleus|||Required for high-fidelity chromosome segregation during the later part of each cell cycle. Acts in opposition to the phosphatase PP1. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension. Phosphorylates histone H3 to form H3S10ph during mitosis and meiosis (By similarity).|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AAR132C ^@ http://purl.uniprot.org/uniprot/Q75EE9 ^@ Similarity ^@ Belongs to the AFG1 ATPase family. http://togogenome.org/gene/284811:AGOS_AFR010C ^@ http://purl.uniprot.org/uniprot/Q754R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDI1 family.|||Binds ubiquitin and polyubiquitinated proteins.|||Cytoplasm|||Probable aspartic protease. May be involved in the regulation of exocytosis. Acts as a linker between the 19S proteasome and polyubiquitinated proteins via UBA domain interactions with ubiquitin for their subsequent degradation. Required for S-phase checkpoint control. http://togogenome.org/gene/284811:AGOS_ACL116W ^@ http://purl.uniprot.org/uniprot/Q75CN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ABR046C ^@ http://purl.uniprot.org/uniprot/Q75DH9 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/284811:AGOS_ACR184C ^@ http://purl.uniprot.org/uniprot/Q75BT7 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/284811:AGOS_AMI007W ^@ http://purl.uniprot.org/uniprot/Q75G38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. A homomeric c-ring of probably 10 subunits is part of the complex rotary element.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_ABR034W ^@ http://purl.uniprot.org/uniprot/Q75DJ0 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/284811:AGOS_ACR140C ^@ http://purl.uniprot.org/uniprot/Q75BY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Catalyzes the terminal and only committed step in triacylglycerol (TAG) synthesis by using diacylglycerol (DAG) and fatty acyl-CoA as substrates. Required for storage lipid synthesis. Major DAG esterifying enzyme in stationary phase when TAG production is particularly active. Involved in lipid particle synthesis from the endoplasmic reticulum, promoting localized TAG production at discrete ER subdomains.|||Endoplasmic reticulum membrane|||Lipid droplet http://togogenome.org/gene/284811:AGOS_ACR202W ^@ http://purl.uniprot.org/uniprot/Q75BR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AER319W ^@ http://purl.uniprot.org/uniprot/Q756E6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/284811:AGOS_AGL113C ^@ http://purl.uniprot.org/uniprot/Q750Q5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/284811:AGOS_AAL093C ^@ http://purl.uniprot.org/uniprot/Q75F21 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/284811:AGOS_ADL305C ^@ http://purl.uniprot.org/uniprot/Q75B77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/284811:AGOS_ABR186W ^@ http://purl.uniprot.org/uniprot/Q75D37 ^@ Function|||Similarity ^@ Belongs to the PanB family.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate. http://togogenome.org/gene/284811:AGOS_AER322C ^@ http://purl.uniprot.org/uniprot/Q756E3 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/284811:AGOS_ABR222W ^@ http://purl.uniprot.org/uniprot/Q75D00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AGL171W ^@ http://purl.uniprot.org/uniprot/Q750W0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACL126W ^@ http://purl.uniprot.org/uniprot/Q75CP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P).|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ACR115W ^@ http://purl.uniprot.org/uniprot/Q75C04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AER310W ^@ http://purl.uniprot.org/uniprot/Q756G1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the respiratory chain complex III/complex IV supercomplex.|||Belongs to the RCF1 family.|||Cytochrome c oxidase subunit which plays a role in assembly of respiratory supercomplexes.|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_AFR201C ^@ http://purl.uniprot.org/uniprot/Q753X1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion inner membrane|||Required for mitochondrial cytochrome c oxidase (COX) assembly and respiration. http://togogenome.org/gene/284811:AGOS_AER172C ^@ http://purl.uniprot.org/uniprot/Q756T1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR210C ^@ http://purl.uniprot.org/uniprot/Q75BR1 ^@ Similarity ^@ In the C-terminal section; belongs to the AIR carboxylase family. Class I subfamily. http://togogenome.org/gene/284811:AGOS_ADL200C ^@ http://purl.uniprot.org/uniprot/Q75AX0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ADR171C ^@ http://purl.uniprot.org/uniprot/Q759V1 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/284811:AGOS_ADL095W ^@ http://purl.uniprot.org/uniprot/Q75AL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACL072C ^@ http://purl.uniprot.org/uniprot/Q75CJ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER258C ^@ http://purl.uniprot.org/uniprot/Q756J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RTC5 family.|||Cytoplasm|||May be involved in a process influencing telomere capping. http://togogenome.org/gene/284811:AGOS_AGL093W ^@ http://purl.uniprot.org/uniprot/Q9HF56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Involved in development of cell polarity during the cell division cycle. Required for the establishment of actin polarization in germ cells. http://togogenome.org/gene/284811:AGOS_AEL331W ^@ http://purl.uniprot.org/uniprot/Q758T3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR026C ^@ http://purl.uniprot.org/uniprot/Q750C9 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Stimulates the activity of serine palmitoyltransferase (SPT). http://togogenome.org/gene/284811:AGOS_AFR354C ^@ http://purl.uniprot.org/uniprot/Q753G0 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily. http://togogenome.org/gene/284811:AGOS_ABR081C ^@ http://purl.uniprot.org/uniprot/Q75DE6 ^@ Similarity ^@ Belongs to the EIS1 family. http://togogenome.org/gene/284811:AGOS_ACR125W ^@ http://purl.uniprot.org/uniprot/Q75BZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/284811:AGOS_ACR051C ^@ http://purl.uniprot.org/uniprot/Q75C65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AEL128C ^@ http://purl.uniprot.org/uniprot/Q757Y8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. SET2 subfamily.|||Chromosome|||Histone methyltransferase that trimethylates histone H3 'Lys-36' forming H3K36me3. Involved in transcription elongation as well as in transcription repression.|||Nucleus|||The AWS and SET domains are necessary for transcription repression. http://togogenome.org/gene/284811:AGOS_ADR152C ^@ http://purl.uniprot.org/uniprot/Q759X1 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AFL029W ^@ http://purl.uniprot.org/uniprot/Q754V0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RMD9 family.|||Binds the 3'-UTR of mitochondrial mRNAs. Involved in the processing or stability of mitochondrial mRNAs.|||Mitochondrion inner membrane|||Monomer.|||Phosphorylated. Phosphorylation promotes binding to RNA. http://togogenome.org/gene/284811:AGOS_ADR243C ^@ http://purl.uniprot.org/uniprot/Q759N2 ^@ Similarity ^@ Belongs to the CCDC25 family. http://togogenome.org/gene/284811:AGOS_ADL220C ^@ http://purl.uniprot.org/uniprot/Q75AZ0 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/284811:AGOS_ABR155C ^@ http://purl.uniprot.org/uniprot/Q75D68 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/284811:AGOS_AGR327C ^@ http://purl.uniprot.org/uniprot/Q74Z79 ^@ Subcellular Location Annotation ^@ Membrane|||cell wall http://togogenome.org/gene/284811:AGOS_AEL166C ^@ http://purl.uniprot.org/uniprot/Q758B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI second mannose (By similarity). http://togogenome.org/gene/284811:AGOS_AFR400C ^@ http://purl.uniprot.org/uniprot/Q753Q9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/284811:AGOS_AGR068W ^@ http://purl.uniprot.org/uniprot/Q74ZZ0 ^@ Function|||Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. ERG27 subfamily.|||Responsible for the reduction of the keto group on the C-3 of sterols. http://togogenome.org/gene/284811:AGOS_AEL010W ^@ http://purl.uniprot.org/uniprot/Q757M1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/284811:AGOS_ADL380W ^@ http://purl.uniprot.org/uniprot/Q75BE4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/284811:AGOS_AER038C ^@ http://purl.uniprot.org/uniprot/Q757H5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPP381 family.|||Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome.|||Component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL182C ^@ http://purl.uniprot.org/uniprot/Q75AV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR696C ^@ http://purl.uniprot.org/uniprot/Q751X9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/284811:AGOS_AER068C ^@ http://purl.uniprot.org/uniprot/Q757E5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR055W ^@ http://purl.uniprot.org/uniprot/Q75C61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR595W ^@ http://purl.uniprot.org/uniprot/Q752I1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Probable transporter.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ACL014C ^@ http://purl.uniprot.org/uniprot/Q75CC3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasm|||Membrane|||Required for vacuolar protein sorting.|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization. http://togogenome.org/gene/284811:AGOS_ACR056W ^@ http://purl.uniprot.org/uniprot/Q75C60 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/284811:AGOS_ADL098C ^@ http://purl.uniprot.org/uniprot/Q75AM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACL181C ^@ http://purl.uniprot.org/uniprot/Q75CX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 48 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR095C ^@ http://purl.uniprot.org/uniprot/Q75DD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR091W ^@ http://purl.uniprot.org/uniprot/Q75A29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR043W ^@ http://purl.uniprot.org/uniprot/Q75A75 ^@ Function|||Similarity ^@ Belongs to the VPS28 family.|||Component of the ESCRT-I complex (endosomal sorting complex required for transport I), a regulator of vesicular trafficking process. http://togogenome.org/gene/284811:AGOS_AGR164C ^@ http://purl.uniprot.org/uniprot/Q74ZN4 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/284811:AGOS_ACL003C ^@ http://purl.uniprot.org/uniprot/Q75CB4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. PFA4 subfamily.|||Endoplasmic reticulum membrane|||Mediates the reversible addition of palmitate to target proteins, thereby regulating their membrane association and biological function.|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284811:AGOS_AGL082W ^@ http://purl.uniprot.org/uniprot/Q751A1 ^@ Function|||Similarity ^@ Belongs to the UDPGP type 1 family.|||Plays a central role as a glucosyl donor in cellular metabolic pathways. http://togogenome.org/gene/284811:AGOS_ADL364C ^@ http://purl.uniprot.org/uniprot/Q75BD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT2/3/5 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR130C ^@ http://purl.uniprot.org/uniprot/Q75EF1 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/284811:AGOS_AAR008W ^@ http://purl.uniprot.org/uniprot/Q75ES1 ^@ Function|||Similarity ^@ Belongs to the glycosyltransferase 3 family.|||Transfers the glycosyl residue from UDP-Glc to the non-reducing end of alpha-1,4-glucan. http://togogenome.org/gene/284811:AGOS_ACL118C ^@ http://purl.uniprot.org/uniprot/Q75CN7 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/284811:AGOS_AEL181C ^@ http://purl.uniprot.org/uniprot/Q758E3 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/284811:AGOS_ACR043W ^@ http://purl.uniprot.org/uniprot/Q75C73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAD2 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR029W ^@ http://purl.uniprot.org/uniprot/Q75EQ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DASH complex DAM1 family.|||Component of the DASH complex, a microtubule-binding subcomplex of the outer kinetochore that is essential for proper chromosome segregation. The DASH complex mediates the formation and maintenance of bipolar kinetochore-microtubule attachments by forming closed rings around spindle microtubules and establishing interactions with proteins from the central kinetochore (By similarity).|||Nucleus|||The DASH complex oligomerizes to form rings that encircle the microtubules.|||kinetochore|||spindle http://togogenome.org/gene/284811:AGOS_AFR146W ^@ http://purl.uniprot.org/uniprot/Q754C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABR009W ^@ http://purl.uniprot.org/uniprot/Q75DL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingosine N-acyltransferase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL338W ^@ http://purl.uniprot.org/uniprot/Q751N5 ^@ Similarity ^@ Belongs to the ELP6 family. http://togogenome.org/gene/284811:AGOS_ADR135W ^@ http://purl.uniprot.org/uniprot/Q759Y8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEN15 family.|||Non-catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5' and 3' splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body (By similarity).|||tRNA splicing endonuclease is a heterotetramer composed of SEN2, SEN15, SEN34 and SEN54. Interacts directly with SEN34 (By similarity). http://togogenome.org/gene/284811:AGOS_AFR537W ^@ http://purl.uniprot.org/uniprot/Q752N7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. ISWI subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AMI008W ^@ http://purl.uniprot.org/uniprot/P62513 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome b family.|||Binds 2 heme b groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Fungal cytochrome b-c1 complex contains 10 subunits; 3 respiratory subunits, 2 core proteins and 5 low-molecular weight proteins. Cytochrome b-c1 complex is a homodimer.|||Heme 1 (or BL or b562) is low-potential and absorbs at about 562 nm, and heme 2 (or BH or b566) is high-potential and absorbs at about 566 nm.|||Mitochondrion inner membrane|||The protein contains only eight transmembrane helices, not nine as predicted by bioinformatics tools. http://togogenome.org/gene/284811:AGOS_AAL117C ^@ http://purl.uniprot.org/uniprot/Q75F45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284811:AGOS_ACL050W ^@ http://purl.uniprot.org/uniprot/Q75CG9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle. Interacts with NOP7 and RRP1. Interacts with RSA4 (via WD repeats).|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR357C ^@ http://purl.uniprot.org/uniprot/Q759C0 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/284811:AGOS_ADR251W ^@ http://purl.uniprot.org/uniprot/Q759M5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/284811:AGOS_AFR677C ^@ http://purl.uniprot.org/uniprot/Q751Z8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR011W ^@ http://purl.uniprot.org/uniprot/Q754R1 ^@ Similarity ^@ Belongs to the alkylbase DNA glycosidase AlkA family. http://togogenome.org/gene/284811:AGOS_ADR169C ^@ http://purl.uniprot.org/uniprot/Q759V3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284811:AGOS_AFR549W ^@ http://purl.uniprot.org/uniprot/Q752M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S10 family.|||Protease with a carboxypeptidase B-like function involved in the C-terminal processing of the lysine and arginine residues from protein precursors. Promotes cell fusion and is involved in the programmed cell death (By similarity).|||trans-Golgi network membrane http://togogenome.org/gene/284811:AGOS_AER139C ^@ http://purl.uniprot.org/uniprot/Q756X5 ^@ Function|||Similarity ^@ Belongs to the dihydroxyacetone kinase (DAK) family.|||Catalyzes both the phosphorylation of dihydroxyacetone and of glyceraldehyde. http://togogenome.org/gene/284811:AGOS_AFR176W ^@ http://purl.uniprot.org/uniprot/Q753Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR120C ^@ http://purl.uniprot.org/uniprot/Q75DA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACR263C ^@ http://purl.uniprot.org/uniprot/Q75BK8 ^@ Similarity ^@ In the central section; belongs to the metallo-dependent hydrolases superfamily. DHOase family. CAD subfamily. http://togogenome.org/gene/284811:AGOS_ABR221C ^@ http://purl.uniprot.org/uniprot/Q75D01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ACR004W ^@ http://purl.uniprot.org/uniprot/Q75CA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_ADR344W ^@ http://purl.uniprot.org/uniprot/Q759D3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts in a DNA repair pathway for removal of UV-induced DNA damage that is distinct from classical nucleotide excision repair and in repair of ionizing radiation damage. Functions in homologous recombination repair of DNA double strand breaks and in recovery of stalled replication forks.|||Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL187W ^@ http://purl.uniprot.org/uniprot/Q750X6 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/284811:AGOS_ACL017C ^@ http://purl.uniprot.org/uniprot/Q75CC6 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated by ESA1 and/or GCN5 to form H2A.ZK3Ac, H2A.ZK8Ac, H2A.ZK10Ac and H2A.ZK14Ac once deposited into chromatin. Acetylation is required for function at telomeres. H2A.ZK14Ac is acetylated at the promoters of active genes (By similarity).|||Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. H2A or its variant H2A.Z forms a heterodimer with H2B. H2A.Z associates with the VPS72/SWC2 subunit of the SWR1 chromatin remodeling complex. Interacts also with RBP1/DNA-directed RNA polymerase II largest subunit (By similarity).|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2A.ZK3ac = acetylated Lys-4; H2A.ZK8ac = acetylated Lys-9; H2A.ZK10ac = acetylated Lys-11; H2A.ZK14ac = acetylated Lys-15.|||Variant histone H2A which can replace H2A in some nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. This variant is enriched at promoters, it may keep them in a repressed state until the appropriate activation signal is received. Near telomeres, it may counteract gene silencing caused by the spread of heterochromatin proteins. Required for the RNA polymerase II and SPT15/TBP recruitment to the target genes. Involved in chromosome stability (By similarity). http://togogenome.org/gene/284811:AGOS_AFL008W ^@ http://purl.uniprot.org/uniprot/Q754S9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR070C ^@ http://purl.uniprot.org/uniprot/Q75EK9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABR189W ^@ http://purl.uniprot.org/uniprot/Q75D34 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PROPPIN family.|||Contains a beta-propeller domain involved in specific binding to phosphatidylinositol 3,5-bisphosphate (PIP2).|||Cytoplasm|||Membrane|||Required for cytoplasm to vacuole transport (Cvt) vesicles formation and mitophagy. Involved in binding of phosphatidylethanolamine to ATG8 and in recruitment of ATG8 and ATG5 to the pre-autophagosomal structure. Protects ATG8 from ARG4-mediated cleavage (By similarity).|||The L/FRRG motif is essential for the cytoplasm to vacuole transport (Cvt) pathway and for the recruitment of ATG8 and ATG16 to the PAS in nutrient-rich medium and in both its recruitment to and dissociation from the PAS under starvation conditions.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_AFL023C ^@ http://purl.uniprot.org/uniprot/Q754U4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSA1 family.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_AER011C ^@ http://purl.uniprot.org/uniprot/Q757K1 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/284811:AGOS_AER187W ^@ http://purl.uniprot.org/uniprot/Q756R7 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/284811:AGOS_AGL277W ^@ http://purl.uniprot.org/uniprot/Q751I3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADL052W ^@ http://purl.uniprot.org/uniprot/Q75AH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MRG family.|||Component of the NuA4 histone acetyltransferase complex.|||Involved in deacetylation of histones, chromatin assembly and chromosome segregation. May act as a transcriptional oscillator, directing histone deacetylases to specific chromosomal domains. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL014C ^@ http://purl.uniprot.org/uniprot/Q750G7 ^@ Similarity ^@ Belongs to the RRP12 family. http://togogenome.org/gene/284811:AGOS_AGR039C ^@ http://purl.uniprot.org/uniprot/Q750B8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR069C ^@ http://purl.uniprot.org/uniprot/Q75A50 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/284811:AGOS_AGL314C ^@ http://purl.uniprot.org/uniprot/Q751L5 ^@ Similarity ^@ Belongs to the peptidase C12 family. http://togogenome.org/gene/284811:AGOS_ADR118C ^@ http://purl.uniprot.org/uniprot/Q75A12 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AEL319C ^@ http://purl.uniprot.org/uniprot/Q758S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLX9 family.|||Interacts with the 35S, 23S and 20S pre-rRNAs and with the U3 snoRNA.|||Involved in ribosome biogenesis. Required for normal pre-rRNA processing in internal transcribed spacer 1 (ITS1). May be involved in the movements of the replication forks (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AER304C ^@ http://purl.uniprot.org/uniprot/Q756G2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. TOM1/PTR1 subfamily.|||Probable ubiquitin ligase protein, which may be involved in mRNA export. E3 ubiquitin ligase proteins mediate ubiquitination and subsequent proteasomal degradation of target proteins. Participates in mRNA export from the nucleus by regulating the transport of hnRNP proteins.|||nucleolus http://togogenome.org/gene/284811:AGOS_AGL330W ^@ http://purl.uniprot.org/uniprot/Q751M7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABL185C ^@ http://purl.uniprot.org/uniprot/Q75E55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFL162C ^@ http://purl.uniprot.org/uniprot/Q755I5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/284811:AGOS_ADL301C ^@ http://purl.uniprot.org/uniprot/Q75B73 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/284811:AGOS_ADL293W ^@ http://purl.uniprot.org/uniprot/Q75B65 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Endosome membrane|||Preautophagosomal structure membrane|||Required for cytoplasm to vacuole transport (Cvt), pexophagy and mitophagy. Also involved in endoplasmic reticulum-specific autophagic process and is essential for the survival of cells subjected to severe ER stress. Functions in protein retrieval from the endocytic pathway (By similarity).|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization of ATG20 to the perivacuolar punctate structures. http://togogenome.org/gene/284811:AGOS_AEL265W ^@ http://purl.uniprot.org/uniprot/Q758U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER358C ^@ http://purl.uniprot.org/uniprot/Q756A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/284811:AGOS_AAR143W ^@ http://purl.uniprot.org/uniprot/Q75ED8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/284811:AGOS_AGL023W ^@ http://purl.uniprot.org/uniprot/Q750H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR366W ^@ http://purl.uniprot.org/uniprot/Q74Z40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL184W ^@ http://purl.uniprot.org/uniprot/Q750X3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the crooked-neck family.|||Involved in pre-mRNA splicing and cell cycle progression. Required for the spliceosome assembly and initiation of the DNA replication (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFL197C ^@ http://purl.uniprot.org/uniprot/Q755L1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Homodimer.|||Mitochondrion|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/284811:AGOS_ABR122C ^@ http://purl.uniprot.org/uniprot/Q75DA2 ^@ Similarity ^@ Belongs to the PdxS/SNZ family. http://togogenome.org/gene/284811:AGOS_AFR199C ^@ http://purl.uniprot.org/uniprot/Q753X3 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/284811:AGOS_AAR067W ^@ http://purl.uniprot.org/uniprot/Q75EL2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/284811:AGOS_AAL169C ^@ http://purl.uniprot.org/uniprot/Q75F85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC3 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR236C ^@ http://purl.uniprot.org/uniprot/Q753T9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen. http://togogenome.org/gene/284811:AGOS_ABR005C ^@ http://purl.uniprot.org/uniprot/Q75DL3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/284811:AGOS_AFR410W ^@ http://purl.uniprot.org/uniprot/Q753B4 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_AAR085W ^@ http://purl.uniprot.org/uniprot/Q75EJ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ABR178C ^@ http://purl.uniprot.org/uniprot/Q75D45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL056C ^@ http://purl.uniprot.org/uniprot/Q75EY4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/284811:AGOS_ADR072C ^@ http://purl.uniprot.org/uniprot/Q75A47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NOP14 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AGR145C ^@ http://purl.uniprot.org/uniprot/Q74ZQ3 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/284811:AGOS_ADL390W ^@ http://purl.uniprot.org/uniprot/Q75BF4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/284811:AGOS_ACR288W ^@ http://purl.uniprot.org/uniprot/Q75BI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).|||Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AER335W ^@ http://purl.uniprot.org/uniprot/Q756D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Cytoplasm|||Mevalonate kinase; part of the second module of ergosterol biosynthesis pathway that includes the middle steps of the pathway. The second module is carried out in the vacuole and involves the formation of farnesyl diphosphate, which is also an important intermediate in the biosynthesis of ubiquinone, dolichol, heme and prenylated proteins. http://togogenome.org/gene/284811:AGOS_ACL110W ^@ http://purl.uniprot.org/uniprot/Q75CM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 5A family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ABR232C ^@ http://purl.uniprot.org/uniprot/Q75CZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFU1 family.|||Endosome|||Inhibitor of the DOA4 deubiquitinase involved in the regulation of protein degradation by the proteasome and maintenance of a normal level of free ubiquitin. http://togogenome.org/gene/284811:AGOS_ABR198C ^@ http://purl.uniprot.org/uniprot/Q75D24 ^@ Similarity ^@ Belongs to the DODA-type extradiol aromatic ring-opening dioxygenase family. http://togogenome.org/gene/284811:AGOS_AFL182C ^@ http://purl.uniprot.org/uniprot/Q755Q2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 9 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL225C ^@ http://purl.uniprot.org/uniprot/Q751D1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits and is required for the normal formation of 25S and 5.8S rRNAs.|||Associated with pre-ribosomal particles.|||Belongs to the DEAD box helicase family. DDX51/DBP6 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL136C ^@ http://purl.uniprot.org/uniprot/Q75AQ6 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/284811:AGOS_AFR541W ^@ http://purl.uniprot.org/uniprot/Q752N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRG7 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADL373W ^@ http://purl.uniprot.org/uniprot/Q75BD7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_AFR159C ^@ http://purl.uniprot.org/uniprot/Q754H9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_ADR170C ^@ http://purl.uniprot.org/uniprot/Q759V2 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/284811:AGOS_AGR270W ^@ http://purl.uniprot.org/uniprot/Q74ZC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 4 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR354W ^@ http://purl.uniprot.org/uniprot/Q759C3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/284811:AGOS_ACL151C ^@ http://purl.uniprot.org/uniprot/Q75CS0 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/284811:AGOS_ADL298C ^@ http://purl.uniprot.org/uniprot/Q75B70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CLASP family.|||Interacts with microtubules.|||Microtubule binding protein that promotes the stabilization of dynamic microtubules. Required for mitotic spindle formation (By similarity).|||Nucleus|||cytoskeleton|||spindle http://togogenome.org/gene/284811:AGOS_AER357C ^@ http://purl.uniprot.org/uniprot/Q756B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/284811:AGOS_ACR030W ^@ http://purl.uniprot.org/uniprot/Q75C86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid/polyamine transporter 2 family.|||Vacuole membrane http://togogenome.org/gene/284811:AGOS_ABR184C ^@ http://purl.uniprot.org/uniprot/Q9HF53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS14 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ADR114C ^@ http://purl.uniprot.org/uniprot/Q75A10 ^@ Similarity ^@ Belongs to the VPS72/YL1 family. http://togogenome.org/gene/284811:AGOS_AGL112C ^@ http://purl.uniprot.org/uniprot/Q750Q4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase required for mitochondrial splicing of group I and II introns. Also required for efficient mitochondrial translation (By similarity).|||Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily.|||Mitochondrion matrix|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_ADL170C ^@ http://purl.uniprot.org/uniprot/Q75AU0 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/284811:AGOS_AAL141C ^@ http://purl.uniprot.org/uniprot/Q75F69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/284811:AGOS_AFR051W ^@ http://purl.uniprot.org/uniprot/Q754M1 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/284811:AGOS_AGR252C ^@ http://purl.uniprot.org/uniprot/Q74ZE7 ^@ Similarity ^@ Belongs to the RRP15 family. http://togogenome.org/gene/284811:AGOS_AEL277C ^@ http://purl.uniprot.org/uniprot/Q758N2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activates the ATG1 kinase in a nutritional condition dependent manner through the TOR pathway, leading to autophagy. Also involved in cytoplasm to vacuole transport (Cvt) and more specifically in Cvt vesicle formation. Seems to play a role in the switching machinery regulating the conversion between the Cvt pathway and autophagy. Finally, ATG13 is also required for glycogen storage during stationary phase (By similarity).|||Belongs to the ATG13 family. Fungi subfamily.|||Cytoplasm|||Interacts with ATG1 to form the ATG1-ATG13 kinase complex.|||Preautophagosomal structure http://togogenome.org/gene/284811:AGOS_ADL033W ^@ http://purl.uniprot.org/uniprot/Q75AF0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/284811:AGOS_AAL149C ^@ http://purl.uniprot.org/uniprot/Q75F77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF alpha subunit family.|||Nucleus|||TFIIF is a general transcription initiation factor that binds to RNA polymerase II and helps to recruit it to the initiation complex in collaboration with TFIIB. It promotes transcription elongation. http://togogenome.org/gene/284811:AGOS_ABR191C ^@ http://purl.uniprot.org/uniprot/Q75D32 ^@ Similarity ^@ Belongs to the MGR2 family. http://togogenome.org/gene/284811:AGOS_ADL092W ^@ http://purl.uniprot.org/uniprot/Q75B02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABL058C ^@ http://purl.uniprot.org/uniprot/Q75DT4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/284811:AGOS_AGR008W ^@ http://purl.uniprot.org/uniprot/Q750E7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/284811:AGOS_AER083C ^@ http://purl.uniprot.org/uniprot/Q757D0 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/284811:AGOS_AFL131W ^@ http://purl.uniprot.org/uniprot/Q755F4 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily. http://togogenome.org/gene/284811:AGOS_AGR016W ^@ http://purl.uniprot.org/uniprot/Q750D9 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/284811:AGOS_AFR501C ^@ http://purl.uniprot.org/uniprot/Q752S2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/284811:AGOS_AEL208W ^@ http://purl.uniprot.org/uniprot/Q758H0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP, AMP, or fructose 2,6-bisphosphate, and allosterically inhibited by ATP or citrate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade 'E' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Heterooctamer of 4 alpha and 4 beta chains.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284811:AGOS_AFR133C ^@ http://purl.uniprot.org/uniprot/Q754D7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR058W ^@ http://purl.uniprot.org/uniprot/Q75EM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTR86 family.|||Cytoplasm|||Essential protein which may be involved in threonine biosynthesis. http://togogenome.org/gene/284811:AGOS_AER210C ^@ http://purl.uniprot.org/uniprot/Q756P4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/284811:AGOS_ACL141C ^@ http://purl.uniprot.org/uniprot/Q75CR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_ACR130W ^@ http://purl.uniprot.org/uniprot/Q75BZ0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/284811:AGOS_AEL312C ^@ http://purl.uniprot.org/uniprot/Q758R5 ^@ Similarity ^@ Belongs to the SUN family. http://togogenome.org/gene/284811:AGOS_AGR156C ^@ http://purl.uniprot.org/uniprot/Q74ZP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AGL320C ^@ http://purl.uniprot.org/uniprot/Q751L7 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/284811:AGOS_ABL201W ^@ http://purl.uniprot.org/uniprot/Q75E71 ^@ Caution|||Similarity ^@ Belongs to the globin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284811:AGOS_AFR383C ^@ http://purl.uniprot.org/uniprot/Q753D3 ^@ Similarity ^@ Belongs to the AIM32 family. http://togogenome.org/gene/284811:AGOS_AFL228W ^@ http://purl.uniprot.org/uniprot/Q755P1 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/284811:AGOS_AFR293C ^@ http://purl.uniprot.org/uniprot/Q753L9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||Nucleus|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). http://togogenome.org/gene/284811:AGOS_AEL220C ^@ http://purl.uniprot.org/uniprot/Q758I2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 5 (cellulase A) family. http://togogenome.org/gene/284811:AGOS_AEL150W ^@ http://purl.uniprot.org/uniprot/Q758D8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL39 family.|||Interacts with YIH1. http://togogenome.org/gene/284811:AGOS_AGL027W ^@ http://purl.uniprot.org/uniprot/Q750H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oligopeptide OPT transporter family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL188W ^@ http://purl.uniprot.org/uniprot/Q758F0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Homotetramer.|||In eukaryotes there are two forms of the enzymes: a cytosolic one and a mitochondrial one.|||Interconversion of serine and glycine.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR405W ^@ http://purl.uniprot.org/uniprot/Q753B9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/284811:AGOS_AGL047C ^@ http://purl.uniprot.org/uniprot/Q750J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR161W ^@ http://purl.uniprot.org/uniprot/Q759W1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RMT2 methyltransferase family.|||Cytoplasm|||Monomer.|||Nucleus|||S-adenosyl-L-methionine-dependent protein-arginine N-methyltransferase that methylates the delta-nitrogen atom of arginine residues to form N5-methylarginine (type IV) in target proteins. Monomethylates ribosomal protein L12. http://togogenome.org/gene/284811:AGOS_AFL177W ^@ http://purl.uniprot.org/uniprot/Q755K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ACR274W ^@ http://purl.uniprot.org/uniprot/Q75BJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM RBM34 family.|||Involved in pre-25S rRNA processing.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR094C ^@ http://purl.uniprot.org/uniprot/Q754I2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/284811:AGOS_AGL241W ^@ http://purl.uniprot.org/uniprot/Q751E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM44 family.|||Cytoplasm|||Probable adenosyl-L-methionine (AdoMet)-dependent tRNA (uracil-O(2)-)-methyltransferase. http://togogenome.org/gene/284811:AGOS_AER218C ^@ http://purl.uniprot.org/uniprot/Q756N6 ^@ Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Allantoinase family.|||Homotetramer. http://togogenome.org/gene/284811:AGOS_ABR202C ^@ http://purl.uniprot.org/uniprot/Q75D20 ^@ Function|||Subcellular Location Annotation ^@ Acts as component of the general transcription and DNA repair factor IIH (TFIIH or factor B), which is essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA. TFIIH as CTD kinase activity and DNA-dependent ATPase activity, and is essential for polymerase II transcription (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL036W ^@ http://purl.uniprot.org/uniprot/Q75CF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GET2 family.|||Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET1, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. http://togogenome.org/gene/284811:AGOS_AFR328C ^@ http://purl.uniprot.org/uniprot/Q753I4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||Required for pre-18S rRNA processing. May bind microtubules (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR176W ^@ http://purl.uniprot.org/uniprot/Q759U7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. Plays a central role in positioning the mitotic spindle at the bud neck during cell division. Targets cytoplasmic dynein to microtubule plus ends, thereby promoting dynein-mediated microtubule sliding along the bud cortex and consequently the movement of the mitotic spindle to the bud neck.|||Self-associates. Interacts with NDL1 and dynein.|||cytoskeleton|||spindle pole http://togogenome.org/gene/284811:AGOS_AER130W ^@ http://purl.uniprot.org/uniprot/Q756Y4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFL189W ^@ http://purl.uniprot.org/uniprot/Q755K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR039C ^@ http://purl.uniprot.org/uniprot/Q754N3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/284811:AGOS_ACR007W ^@ http://purl.uniprot.org/uniprot/Q75CA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL315C ^@ http://purl.uniprot.org/uniprot/Q75B85 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AFR374C ^@ http://purl.uniprot.org/uniprot/Q753E2 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/284811:AGOS_ABL023W ^@ http://purl.uniprot.org/uniprot/Q75DP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR314C ^@ http://purl.uniprot.org/uniprot/Q759G2 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/284811:AGOS_AGL268C ^@ http://purl.uniprot.org/uniprot/Q751H4 ^@ Similarity ^@ Belongs to the TTC4 family. http://togogenome.org/gene/284811:AGOS_AGR323C ^@ http://purl.uniprot.org/uniprot/Q74Z83 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AEL270W ^@ http://purl.uniprot.org/uniprot/Q758V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HDA2/3 family. HDA3 subfamily.|||Nucleus|||Probable component of some histone deacetylase complex.|||Required for activity of histone deacetylase complexes that are responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events (By similarity). http://togogenome.org/gene/284811:AGOS_ADL222W ^@ http://purl.uniprot.org/uniprot/Q75AZ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FYV10 family.|||Cytoplasm|||Involved in the proteasome-dependent degradation of fructose-1,6-bisphosphatase.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAR036W ^@ http://purl.uniprot.org/uniprot/Q75EP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Mitochondrial transporter that mediates uptake of thiamine pyrophosphate (ThPP) into mitochondria.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AEL137W ^@ http://purl.uniprot.org/uniprot/Q757Z7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/284811:AGOS_AFR419C ^@ http://purl.uniprot.org/uniprot/Q753A5 ^@ Similarity ^@ Belongs to the actin family. ARP3 subfamily. http://togogenome.org/gene/284811:AGOS_ADR145C ^@ http://purl.uniprot.org/uniprot/Q759X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||cytoskeleton http://togogenome.org/gene/284811:AGOS_AGR001W ^@ http://purl.uniprot.org/uniprot/Q750F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LOC1 family.|||Component of the 66S pre-ribosomal particle.|||Required for efficient assembly and nuclear export of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR202C ^@ http://purl.uniprot.org/uniprot/Q759S1 ^@ Similarity ^@ Belongs to the putative lipase ROG1 family. http://togogenome.org/gene/284811:AGOS_AEL189W ^@ http://purl.uniprot.org/uniprot/Q758F1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR112W ^@ http://purl.uniprot.org/uniprot/Q75A02 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/284811:AGOS_AFR619W ^@ http://purl.uniprot.org/uniprot/Q752F7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SOP4 family.|||Endoplasmic reticulum membrane|||Involved in the export of PMA1, possibly through the monitoring or assisting of PMA1 folding and acquisition of competence to enter vesicles. http://togogenome.org/gene/284811:AGOS_ACL042W ^@ http://purl.uniprot.org/uniprot/Q75CG1 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/284811:AGOS_AGR359C ^@ http://purl.uniprot.org/uniprot/Q74Z47 ^@ Function|||Similarity ^@ Belongs to the AB hydrolase superfamily.|||Demethylates proteins that have been reversibly carboxymethylated. Demethylates the phosphatase PP2A catalytic subunit (By similarity). http://togogenome.org/gene/284811:AGOS_AFL191W ^@ http://purl.uniprot.org/uniprot/Q755K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_ACR074W ^@ http://purl.uniprot.org/uniprot/Q75C43 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Endosome membrane|||Preautophagosomal structure membrane|||Sorting nexin, involved in the separation or division of vacuoles throughout the entire life cycle of the cells. Involved in retrieval of late-Golgi SNAREs from post-Golgi endosomes to the trans-Golgi network, for cytoplasm to vacuole transport (Cvt), autophagy, mitophagy, and pexophagy.|||The PX domain binds phosphatidylinositol 3-phosphate which is necessary for peripheral membrane localization to the perivacuolar punctate structures.|||cytosol http://togogenome.org/gene/284811:AGOS_AGR144C ^@ http://purl.uniprot.org/uniprot/Q9HF75 ^@ Function ^@ GTPase-activating protein (GAP) for RHO proteins. Required for polarized growth and maintenance of cell polarity. http://togogenome.org/gene/284811:AGOS_AGL344C ^@ http://purl.uniprot.org/uniprot/Q751S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AEL030W ^@ http://purl.uniprot.org/uniprot/Q757P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. YAT (TC 2.A.3.10) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR195W ^@ http://purl.uniprot.org/uniprot/Q753X7 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/284811:AGOS_AGR126C ^@ http://purl.uniprot.org/uniprot/Q74ZS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGO subfamily.|||Endoplasmic reticulum membrane|||Involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the GPI third mannose which links the GPI-anchor to the C-terminus of the proteins by an amide bond. Involved in cell wall biosynthesis (By similarity). http://togogenome.org/gene/284811:AGOS_ACL005C ^@ http://purl.uniprot.org/uniprot/Q75CF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AAL011C ^@ http://purl.uniprot.org/uniprot/Q75ET5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL30 family.|||Involved in the biogenesis of the 60S ribosomal subunit. May act as a specificity factor that binds precursor rRNAs and tethers the enzymes that carry out the early 5' to 3' exonucleolytic reactions that generate the mature rRNAs (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ABL003C ^@ http://purl.uniprot.org/uniprot/Q75DM0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR090W ^@ http://purl.uniprot.org/uniprot/Q754Y4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AAR116W ^@ http://purl.uniprot.org/uniprot/Q75EU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Involved in pre-mRNA splicing. Binds and is required for the stability of snRNA U1, U2, U4 and U5 which contain a highly conserved structural motif called the Sm binding site. Involved in cap modification.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR081C ^@ http://purl.uniprot.org/uniprot/Q74ZX7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/284811:AGOS_ADR180C ^@ http://purl.uniprot.org/uniprot/Q759U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AFR036C ^@ http://purl.uniprot.org/uniprot/Q754N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR420W ^@ http://purl.uniprot.org/uniprot/Q753A4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. http://togogenome.org/gene/284811:AGOS_ADL289C ^@ http://purl.uniprot.org/uniprot/Q75B61 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AER020W ^@ http://purl.uniprot.org/uniprot/Q757J3 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/284811:AGOS_ABL208W ^@ http://purl.uniprot.org/uniprot/Q75E74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid transfer protein required for autophagosome completion and peroxisome degradation. Tethers the edge of the isolation membrane (IM) to the endoplasmic reticulum (ER) and mediates direct lipid transfer from ER to IM for IM expansion. ATG2 binds to the ER exit site (ERES), which is the membrane source for autophagosome formation, using basic residues in its N-terminal region (NR) and to the expanding edge of the IM through its C-terminal region. The latter binding is assisted by an ATG18-PtdIns3P interaction. ATG2 then extracts phospholipids from the membrane source using its NR and transfers them to ATG9 to the IM through its predicted beta-sheet-rich structure for membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/284811:AGOS_AEL275C ^@ http://purl.uniprot.org/uniprot/Q758N0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/284811:AGOS_AAL036W ^@ http://purl.uniprot.org/uniprot/Q75EW4 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/284811:AGOS_AFR358W ^@ http://purl.uniprot.org/uniprot/Q753F6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/284811:AGOS_ACL122W ^@ http://purl.uniprot.org/uniprot/Q75CP1 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/284811:AGOS_ACL173C ^@ http://purl.uniprot.org/uniprot/Q75CU2 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/284811:AGOS_AFR503W ^@ http://purl.uniprot.org/uniprot/Q752S0 ^@ Similarity ^@ Belongs to the PRP18 family. http://togogenome.org/gene/284811:AGOS_AFR026C ^@ http://purl.uniprot.org/uniprot/Q754P6 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/284811:AGOS_AGL265W ^@ http://purl.uniprot.org/uniprot/Q751H1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ODC antizyme family.|||Interacts with ODC and thereby sterically blocks ODC homodimerization.|||Ornithine decarboxylase (ODC) antizyme protein that negatively regulates ODC activity and intracellular polyamine biosynthesis in response to increased intracellular polyamine levels. Binds to ODC monomers, inhibiting the assembly of the functional ODC homodimer, and targets the monomers for ubiquitin-independent proteolytic destruction by the 26S proteasome. http://togogenome.org/gene/284811:AGOS_ABL210C ^@ http://purl.uniprot.org/uniprot/Q75E76 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL078C ^@ http://purl.uniprot.org/uniprot/Q757U0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/284811:AGOS_ACR072C ^@ http://purl.uniprot.org/uniprot/Q75C45 ^@ Function|||Similarity ^@ Acts as a regulatory subunit of the 26 proteasome which is involved in the ATP-dependent degradation of ubiquitinated proteins.|||Belongs to the proteasome subunit S2 family. http://togogenome.org/gene/284811:AGOS_AFR578C ^@ http://purl.uniprot.org/uniprot/Q752J6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL204W ^@ http://purl.uniprot.org/uniprot/Q75AX4 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/284811:AGOS_AER062C ^@ http://purl.uniprot.org/uniprot/Q757F1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase VIIc family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFR551W ^@ http://purl.uniprot.org/uniprot/Q752M3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284811:AGOS_AER284W ^@ http://purl.uniprot.org/uniprot/Q756X1 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/284811:AGOS_ACR078W ^@ http://purl.uniprot.org/uniprot/Q75C39 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase associated with the nuclear pore complex and essential for mRNA export from the nucleus. May participate in a terminal step of mRNA export through the removal of proteins that accompany mRNA through the nucleopore complex. May also be involved in early transcription (By similarity).|||Associates with the nuclear pore complex.|||Belongs to the DEAD box helicase family. DDX19/DBP5 subfamily.|||Cytoplasm|||Nucleus membrane|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AER448W ^@ http://purl.uniprot.org/uniprot/Q755S0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_AFR273W ^@ http://purl.uniprot.org/uniprot/Q753N9 ^@ Similarity ^@ Belongs to the XPO2/CSE1 family. http://togogenome.org/gene/284811:AGOS_ADR081C ^@ http://purl.uniprot.org/uniprot/Q75A38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Regulates the cell cycle in a nutrient dependent manner. http://togogenome.org/gene/284811:AGOS_ACR040W ^@ http://purl.uniprot.org/uniprot/Q75C76 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).|||Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.|||Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL395C ^@ http://purl.uniprot.org/uniprot/D8FGF0|||http://purl.uniprot.org/uniprot/Q755R1 ^@ Function|||Similarity ^@ Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.|||Belongs to the SUI1 family. http://togogenome.org/gene/284811:AGOS_ACR046W ^@ http://purl.uniprot.org/uniprot/Q75C70 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP9 family.|||RNA-binding nucleolar protein required for pre-rRNA processing. Involved in production of 18S rRNA and assembly of small ribosomal subunit (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ADL311W ^@ http://purl.uniprot.org/uniprot/Q75B83 ^@ Similarity ^@ Belongs to the small Tim family. http://togogenome.org/gene/284811:AGOS_AER202C ^@ http://purl.uniprot.org/uniprot/Q756Q2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284811:AGOS_ADR396W ^@ http://purl.uniprot.org/uniprot/Q758Y2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/284811:AGOS_ADR012C ^@ http://purl.uniprot.org/uniprot/Q75AA6 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/284811:AGOS_AGR055C ^@ http://purl.uniprot.org/uniprot/Q750A2 ^@ Similarity ^@ Belongs to the FMO family. http://togogenome.org/gene/284811:AGOS_ADL347C ^@ http://purl.uniprot.org/uniprot/Q75BB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_ABL038W ^@ http://purl.uniprot.org/uniprot/Q75DQ5 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/284811:AGOS_AFR418W ^@ http://purl.uniprot.org/uniprot/Q753A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL039C ^@ http://purl.uniprot.org/uniprot/Q75AF7 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/284811:AGOS_AFR500W ^@ http://purl.uniprot.org/uniprot/Q752S3 ^@ Subcellular Location Annotation ^@ Peroxisome membrane http://togogenome.org/gene/284811:AGOS_AAR192C ^@ http://purl.uniprot.org/uniprot/Q75E88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL070W ^@ http://purl.uniprot.org/uniprot/Q757T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery. In association with the spliceosomal U4/U6.U5 tri-snRNP particle, required for splicing of pre-mRNA. In association with box C/D snoRNPs, required for processing of pre-ribosomal RNA (rRNA) and site-specific 2'-O-methylation of substrate RNAs. Essential for the accumulation and stability of U4 snRNA, U6 snRNA, and box C/D snoRNAs (By similarity).|||Component of the U3 snoRNP particle. Binds to the C'/D and B/C motifs in U3 snoRNA. Component of the 25S U4/U6.U5 tri-snRNP particle, a subcomplex of the spliceosome. Binds to the 5' stem-loop of U4 snRNA (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_AAL013W ^@ http://purl.uniprot.org/uniprot/O60028 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters. Plays a role in both tRNA-processing and mitochondrial metabolism. Involved in the 2-thio-modification of both 5-carboxymethylaminomethyl-2-thiouridine in mitochondrial tRNAs and 5-methoxycarbonylmethyl-2-thiouridine (mcm5s2U) in cytoplasmic tRNAs.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFR675W ^@ http://purl.uniprot.org/uniprot/Q752A0 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADL127C ^@ http://purl.uniprot.org/uniprot/Q75AP7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/284811:AGOS_ADR253W ^@ http://purl.uniprot.org/uniprot/Q759M3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/284811:AGOS_ADL226C ^@ http://purl.uniprot.org/uniprot/Q75AZ6 ^@ Function|||Similarity ^@ Belongs to the beta-class carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/284811:AGOS_ADR127W ^@ http://purl.uniprot.org/uniprot/Q759Z6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL153C ^@ http://purl.uniprot.org/uniprot/Q75F81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ADIPOR-like receptor involved in zinc metabolism either by altering membrane sterol content or by directly altering cellular zinc levels.|||Belongs to the ADIPOR family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AAL136C ^@ http://purl.uniprot.org/uniprot/Q75F64 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/284811:AGOS_AFR586W ^@ http://purl.uniprot.org/uniprot/Q752I9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR123W ^@ http://purl.uniprot.org/uniprot/Q754E7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diphthine synthase family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/284811:AGOS_AER337W ^@ http://purl.uniprot.org/uniprot/Q756D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the NOP7 complex, composed of ERB1, NOP7 and YTM1. The complex is held together by ERB1, which interacts with NOP7 via its N-terminal domain and with YTM1 via a high-affinity interaction between the seven-bladed beta-propeller domains of the 2 proteins. The NOP7 complex associates with the 66S pre-ribosome. Interacts (via UBL domain) with MDN1 (via VWFA/MIDAS domain).|||Component of the NOP7 complex, which is required for maturation of the 25S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/284811:AGOS_ADR045W ^@ http://purl.uniprot.org/uniprot/Q75A73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21. Interacts with preproteins in transit (By similarity).|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane. Required to direct preproteins in transit and direct them to the channel protein TIM23, and possibly facilitates transfer of the translocating proteins from the TOM complex to the TIM23 complex (By similarity).|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGR176C ^@ http://purl.uniprot.org/uniprot/Q74ZM2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BUR kinase complex.|||Component of the BUR kinase complex involved in transcription regulation. This complex phosphorylates the UBC2/RAD6 ubiquitin-conjugating enzyme (E2), leading to monoubiquitination of histone H2B and the silencing of telomeric-associated genes. Also required for histone H3 methylation. Necessary for the recovery from pheromone-induced growth arrest in the cell cycle G1 phase. The kinase activity of the complex requires the presence of BUR2. Overexpression of BUR2 interferes with mitotic chromosome segregation (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ACR073C ^@ http://purl.uniprot.org/uniprot/Q75C44 ^@ Similarity ^@ Belongs to the peptidase S9B family. http://togogenome.org/gene/284811:AGOS_AFR727W ^@ http://purl.uniprot.org/uniprot/Q751U8 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/284811:AGOS_AFL118W ^@ http://purl.uniprot.org/uniprot/Q755E1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284811:AGOS_AFR480C ^@ http://purl.uniprot.org/uniprot/Q752U3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCM1 family.|||Mitochondrion|||RNA-binding protein involved in the specific removal of group I introns in mitochondrial encoded transcripts. Maintains the stability of the small subunit mitochondrial 15S rRNA and thus the expression of the mitochondrial genome (By similarity). http://togogenome.org/gene/284811:AGOS_AER152W ^@ http://purl.uniprot.org/uniprot/Q756V0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AGL050C ^@ http://purl.uniprot.org/uniprot/Q750K1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284811:AGOS_ACL187W ^@ http://purl.uniprot.org/uniprot/Q75CV3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ADL074W ^@ http://purl.uniprot.org/uniprot/Q75AK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AFR527W ^@ http://purl.uniprot.org/uniprot/Q752P6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL014W ^@ http://purl.uniprot.org/uniprot/Q75AD1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AFL067W ^@ http://purl.uniprot.org/uniprot/Q754Z3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AEL007W ^@ http://purl.uniprot.org/uniprot/Q757M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL102W ^@ http://purl.uniprot.org/uniprot/Q757W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFR529W ^@ http://purl.uniprot.org/uniprot/Q752P4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/284811:AGOS_AFR138W ^@ http://purl.uniprot.org/uniprot/Q754D2 ^@ Similarity|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer. http://togogenome.org/gene/284811:AGOS_AAL054W ^@ http://purl.uniprot.org/uniprot/Q75EY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS41 family.|||Involved in telomere length regulation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AER133C ^@ http://purl.uniprot.org/uniprot/Q756Y1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus|||ORC is composed of six subunits. http://togogenome.org/gene/284811:AGOS_AGL134C ^@ http://purl.uniprot.org/uniprot/Q750S3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pseudouridine synthase RluA family.|||Mitochondrion|||Pseudouridylate synthase responsible for the pseudouridine-2819 formation in mitochondrial 21S rRNA. May modulate the efficiency or the fidelity of the mitochondrial translation machinery. http://togogenome.org/gene/284811:AGOS_AFR280W ^@ http://purl.uniprot.org/uniprot/Q753N2 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/284811:AGOS_ADR358W ^@ http://purl.uniprot.org/uniprot/Q759B9 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/284811:AGOS_AFR568C ^@ http://purl.uniprot.org/uniprot/Q752K6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_ADR041W ^@ http://purl.uniprot.org/uniprot/Q75A77 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR020C ^@ http://purl.uniprot.org/uniprot/Q750D5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNU71 family.|||Component of the U1 snRNP particle, a subcomplex of the spliceosome.|||Component of the U1 snRNP particle, which recognizes and binds the 5'-splice site of pre-mRNA. Together with other non-snRNP factors, U1 snRNP forms the spliceosomal commitment complex, that targets pre-mRNA to the splicing pathway (By similarity).|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR044C ^@ http://purl.uniprot.org/uniprot/Q754M8 ^@ Function|||Similarity ^@ Belongs to the endosulfine family.|||Plays an essential role in initiation of the G0 program by preventing the degradation of specific nutrient-regulated mRNAs via the 5'-3' mRNA decay pathway. http://togogenome.org/gene/284811:AGOS_ACL130C ^@ http://purl.uniprot.org/uniprot/Q75CP9 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/284811:AGOS_AEL343C ^@ http://purl.uniprot.org/uniprot/Q758U5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/284811:AGOS_AAR122C ^@ http://purl.uniprot.org/uniprot/Q75EF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AAR057W ^@ http://purl.uniprot.org/uniprot/Q75EM2 ^@ Similarity ^@ Belongs to the WD repeat PWP2 family. http://togogenome.org/gene/284811:AGOS_ACR164C ^@ http://purl.uniprot.org/uniprot/Q75BV7 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/284811:AGOS_ABR071W ^@ http://purl.uniprot.org/uniprot/Q75DF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. http://togogenome.org/gene/284811:AGOS_ACL174W ^@ http://purl.uniprot.org/uniprot/Q75CU3 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/284811:AGOS_AER317W ^@ http://purl.uniprot.org/uniprot/Q756E8 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/284811:AGOS_AAR001C ^@ http://purl.uniprot.org/uniprot/Q75ES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Bud neck http://togogenome.org/gene/284811:AGOS_AFR718W ^@ http://purl.uniprot.org/uniprot/Q751V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/284811:AGOS_AEL338C ^@ http://purl.uniprot.org/uniprot/Q758U0 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/284811:AGOS_ADL261C ^@ http://purl.uniprot.org/uniprot/Q75B38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/284811:AGOS_AEL079W ^@ http://purl.uniprot.org/uniprot/Q757U1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR361W ^@ http://purl.uniprot.org/uniprot/Q759B6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SNW family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL075W ^@ http://purl.uniprot.org/uniprot/Q75AK2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AAL154C ^@ http://purl.uniprot.org/uniprot/Q75F96 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/284811:AGOS_AFR399W ^@ http://purl.uniprot.org/uniprot/Q753R0 ^@ Similarity ^@ Belongs to the IUNH family. http://togogenome.org/gene/284811:AGOS_AER457W ^@ http://purl.uniprot.org/uniprot/D8FGF0|||http://purl.uniprot.org/uniprot/Q755R1 ^@ Function|||Similarity ^@ Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.|||Belongs to the SUI1 family. http://togogenome.org/gene/284811:AGOS_ACR087C ^@ http://purl.uniprot.org/uniprot/Q75C30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284811:AGOS_AFR728W ^@ http://purl.uniprot.org/uniprot/Q751U7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KRE28 family.|||Nucleus membrane|||Required for kinetochore binding by a discrete subset of kMAPs and motors. Involved in kinetochore-microtubule binding and the spindle assembly checkpoint (By similarity).|||kinetochore|||spindle pole body http://togogenome.org/gene/284811:AGOS_AFL221C ^@ http://purl.uniprot.org/uniprot/Q755N4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.|||Associates with polysomes.|||Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||Cytoplasm|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284811:AGOS_AFR246C ^@ http://purl.uniprot.org/uniprot/Q753T0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADL169W ^@ http://purl.uniprot.org/uniprot/Q75AT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0220 family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAR133W ^@ http://purl.uniprot.org/uniprot/Q75EE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAK10 family.|||Cytoplasm http://togogenome.org/gene/284811:AGOS_AER225W ^@ http://purl.uniprot.org/uniprot/Q756M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OSBP family.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL145W ^@ http://purl.uniprot.org/uniprot/Q750T4 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/284811:AGOS_AGR143W ^@ http://purl.uniprot.org/uniprot/E7FHS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/284811:AGOS_AAL086W ^@ http://purl.uniprot.org/uniprot/Q75F14 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/284811:AGOS_AFR610W ^@ http://purl.uniprot.org/uniprot/Q752G6 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family. http://togogenome.org/gene/284811:AGOS_AGL101C ^@ http://purl.uniprot.org/uniprot/Q751B3 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/284811:AGOS_AGR011W ^@ http://purl.uniprot.org/uniprot/Q750E4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR214C ^@ http://purl.uniprot.org/uniprot/Q753V8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/284811:AGOS_ADR364W ^@ http://purl.uniprot.org/uniprot/Q759B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/284811:AGOS_AEL021C ^@ http://purl.uniprot.org/uniprot/Q757N3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284811:AGOS_ACL182C ^@ http://purl.uniprot.org/uniprot/Q75CX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 72 family.|||Cell membrane|||Membrane|||Splits internally a 1,3-beta-glucan molecule and transfers the newly generated reducing end (the donor) to the non-reducing end of another 1,3-beta-glucan molecule (the acceptor) forming a 1,3-beta linkage, resulting in the elongation of 1,3-beta-glucan chains in the cell wall. http://togogenome.org/gene/284811:AGOS_ADL228C ^@ http://purl.uniprot.org/uniprot/Q75AZ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the peripheral membrane COG complex that is involved in intra-Golgi protein trafficking. COG is located at the cis-Golgi, and regulates tethering of retrograde intra-Golgi vesicles and possibly a number of other membrane trafficking events (By similarity).|||Belongs to the COG6 family.|||Golgi apparatus membrane http://togogenome.org/gene/284811:AGOS_AGR134W ^@ http://purl.uniprot.org/uniprot/Q74ZR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL073C ^@ http://purl.uniprot.org/uniprot/Q757T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup85 family.|||Component of the nuclear pore complex (NPC).|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/284811:AGOS_AMI005W ^@ http://purl.uniprot.org/uniprot/Q75G40 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. In yeast, the dimeric form of ATP synthase consists of 18 polypeptides: alpha, beta, gamma, delta, epsilon, 4 (B), 5 (OSCP), 6 (A), 8, 9 (C), d, E (Tim11), f, g, h, i, j and k.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane (By similarity).|||Mitochondrion membrane http://togogenome.org/gene/284811:AGOS_AGR047W ^@ http://purl.uniprot.org/uniprot/Q750B0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AER265W ^@ http://purl.uniprot.org/uniprot/Q756X4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284811:AGOS_AFL031W ^@ http://purl.uniprot.org/uniprot/Q754V2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERT1/acuK family.|||Nucleus|||Transcription factor which regulates nonfermentable carbon utilization. Activator of gluconeogenetic genes (By similarity). http://togogenome.org/gene/284811:AGOS_ACL070C ^@ http://purl.uniprot.org/uniprot/Q75CI9 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/284811:AGOS_AFR084C ^@ http://purl.uniprot.org/uniprot/Q754J0 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/284811:AGOS_AER076C ^@ http://purl.uniprot.org/uniprot/Q757D7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/284811:AGOS_AER074W ^@ http://purl.uniprot.org/uniprot/Q757D9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||E3 ubiquitin-protein ligase that mediates monoubiquitination of histone H2B to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also a prerequisite for H3K4me and H3K79me formation.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL143C ^@ http://purl.uniprot.org/uniprot/Q750T2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR083C ^@ http://purl.uniprot.org/uniprot/Q75DE4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Component of centromeric nucleosomes, where DNA is wrapped around a histone octamer core. The octamer contains two molecules each of H2A, H2B, CSE4/CENPA and H4 assembled in one CSE4-H4 heterotetramer and two H2A-H2B heterodimers. Interacts with the inner kinetochore.|||Histone H3-like nucleosomal protein that is specifically found in centromeric nucleosomes. Replaces conventional H3 in the nucleosome core of centromeric chromatin that serves as an assembly site for the inner kinetochore. Required for recruitment and assembly of kinetochore proteins, mitotic progression and chromosome segregation. May serve as an epigenetic mark that propagates centromere identity through replication and cell division (By similarity).|||Nucleus|||Ubiquitinated. Is degraded through ubiquitin-mediated proteolysis when not protected by its association to the kinetochore.|||centromere http://togogenome.org/gene/284811:AGOS_AFR136C ^@ http://purl.uniprot.org/uniprot/Q754D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL103W ^@ http://purl.uniprot.org/uniprot/Q751B5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/284811:AGOS_ABR228C ^@ http://purl.uniprot.org/uniprot/Q75CZ4 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/284811:AGOS_ADL045W ^@ http://purl.uniprot.org/uniprot/Q75AG3 ^@ Subcellular Location Annotation ^@ Nucleus membrane http://togogenome.org/gene/284811:AGOS_AEL327W ^@ http://purl.uniprot.org/uniprot/Q758S9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AFR665C ^@ http://purl.uniprot.org/uniprot/Q752B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAM41 family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_ADR417W ^@ http://purl.uniprot.org/uniprot/Q758W1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/284811:AGOS_ADR374C ^@ http://purl.uniprot.org/uniprot/Q759A3 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284811:AGOS_AGR235W ^@ http://purl.uniprot.org/uniprot/Q74ZH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AGL041C ^@ http://purl.uniprot.org/uniprot/Q750J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane http://togogenome.org/gene/284811:AGOS_AGL080C ^@ http://purl.uniprot.org/uniprot/Q751A4 ^@ Function|||Similarity ^@ 5-phosphoribose 1-diphosphate synthase involved in nucleotide, histidine, and tryptophan biosynthesis. Active in heteromultimeric complexes with other 5-phosphoribose 1-diphosphate synthases (PRS2, PRS3, PRS4 and PRS5).|||Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/284811:AGOS_ACL129W ^@ http://purl.uniprot.org/uniprot/Q75CP8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF beta-subunit/FixA family.|||Binds 1 AMP per subunit.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/284811:AGOS_AFR265C ^@ http://purl.uniprot.org/uniprot/Q753P7 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/284811:AGOS_AGR363W ^@ http://purl.uniprot.org/uniprot/Q74Z43 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/284811:AGOS_AFR557C ^@ http://purl.uniprot.org/uniprot/Q752L7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway (By similarity).|||nucleolus http://togogenome.org/gene/284811:AGOS_ADR305C ^@ http://purl.uniprot.org/uniprot/Q759I3 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/284811:AGOS_AFL111W ^@ http://purl.uniprot.org/uniprot/Q755D4 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/284811:AGOS_AER437C ^@ http://purl.uniprot.org/uniprot/Q755T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/284811:AGOS_AEL325W ^@ http://purl.uniprot.org/uniprot/Q758S7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the large ribosomal subunit.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AER247W ^@ http://purl.uniprot.org/uniprot/Q756K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/284811:AGOS_AER033W ^@ http://purl.uniprot.org/uniprot/Q757I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS9 family.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AFL209W ^@ http://purl.uniprot.org/uniprot/Q755M3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ALB1 family.|||Component of the nucleoplasmic and cytoplasmic pre-60S ribosomal particles.|||Cytoplasm|||Involved in proper assembly of pre-ribosomal particles during the biogenesis of the 60S ribosomal subunit. Accompanies the pre-60S particles to the cytoplasm (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL128W ^@ http://purl.uniprot.org/uniprot/Q751A8 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/284811:AGOS_AGR028C ^@ http://purl.uniprot.org/uniprot/Q750C7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR085W ^@ http://purl.uniprot.org/uniprot/Q754I9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that mediates the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis. Not involved in the GTP-dependent ribosomal translocation step during translation elongation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGR106C ^@ http://purl.uniprot.org/uniprot/Q74ZU2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP15 family.|||Golgi apparatus membrane|||Golgi membrane protein involved in vesicular trafficking.|||Present with 4540 molecules/cell in log phase SD medium. http://togogenome.org/gene/284811:AGOS_AER199C ^@ http://purl.uniprot.org/uniprot/Q756Q5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrion-specific ribosomal protein mS37 family.|||Component of the mitochondrial small ribosomal subunit.|||Involved in mitochondrial genome encoded proteins translation.|||Mitochondrion http://togogenome.org/gene/284811:AGOS_AGL269W ^@ http://purl.uniprot.org/uniprot/Q751H5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/284811:AGOS_AEL198W ^@ http://purl.uniprot.org/uniprot/Q758G0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/284811:AGOS_ABR067C ^@ http://purl.uniprot.org/uniprot/Q75DF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Peroxisome membrane|||Required for protein import into peroxisomes. http://togogenome.org/gene/284811:AGOS_ACR225C ^@ http://purl.uniprot.org/uniprot/Q75BP6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/284811:AGOS_ABR224W ^@ http://purl.uniprot.org/uniprot/Q75CZ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS3 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284811:AGOS_AER184W ^@ http://purl.uniprot.org/uniprot/Q756S0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion inner membrane|||Monomer. http://togogenome.org/gene/284811:AGOS_ADL176W ^@ http://purl.uniprot.org/uniprot/Q75AU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 2 family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL295C ^@ http://purl.uniprot.org/uniprot/Q758P8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284811:AGOS_AAL016C ^@ http://purl.uniprot.org/uniprot/Q9HF61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD3 family.|||Cell septum|||Cell tip|||Required for proper septum positioning and septum construction during septation. Acts as a landmark to mark sites for future septation, and as part of a scaffold that recruits components of the contractile ring to the site of septation. Not required to determine the site of lateral branch formation. http://togogenome.org/gene/284811:AGOS_AFR592W ^@ http://purl.uniprot.org/uniprot/Q752I3 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/284811:AGOS_ADR179C ^@ http://purl.uniprot.org/uniprot/Q759U4 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/284811:AGOS_AGL363C ^@ http://purl.uniprot.org/uniprot/Q751Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/284811:AGOS_AEL224W ^@ http://purl.uniprot.org/uniprot/Q758I6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284811:AGOS_ABR229C ^@ http://purl.uniprot.org/uniprot/Q75CZ3 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/284811:AGOS_AFR426C ^@ http://purl.uniprot.org/uniprot/Q752Z8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR006C ^@ http://purl.uniprot.org/uniprot/Q754R6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WRB/GET1 family.|||Component of the Golgi to ER traffic (GET) complex, which is composed of GET1, GET2 and GET3. Within the complex, GET1 and GET2 form a heterotetramer which is stabilized by phosphatidylinositol binding and which binds to the GET3 homodimer.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Together with GET2, acts as a membrane receptor for soluble GET3, which recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. The GET complex cooperates with the HDEL receptor ERD2 to mediate the ATP-dependent retrieval of resident ER proteins that contain a C-terminal H-D-E-L retention signal from the Golgi to the ER. http://togogenome.org/gene/284811:AGOS_AEL115C ^@ http://purl.uniprot.org/uniprot/Q758E1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284811:AGOS_AER022W ^@ http://purl.uniprot.org/uniprot/Q757J1 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/284811:AGOS_ABL146C ^@ http://purl.uniprot.org/uniprot/Q75E19 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. CSN5 subfamily.|||Catalytic component of the COP9 signalosome (CSN) complex that acts as an regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunit of SCF-type E3 ubiquitin-protein ligase complexes. The CSN complex is involved in the regulation of the mating pheromone response.|||Component of the COP9 signalosome (CSN) complex.|||Cytoplasm|||Nucleus|||The JAMM motif is essential for the protease activity of the CSN complex resulting in deneddylation of cullins. It constitutes the catalytic center of the complex (By similarity). http://togogenome.org/gene/284811:AGOS_AFL046W ^@ http://purl.uniprot.org/uniprot/Q754W3 ^@ Function|||Similarity ^@ Belongs to the HisA/HisF family.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The glutaminase domain produces the ammonia necessary for the cyclase domain to produce IGP and AICAR from PRFAR. The ammonia is channeled to the active site of the cyclase domain.|||In the C-terminal section; belongs to the HisA/HisF family. http://togogenome.org/gene/284811:AGOS_AGL119C ^@ http://purl.uniprot.org/uniprot/Q750R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||May form heterododecamers with RVB2. Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL042W ^@ http://purl.uniprot.org/uniprot/Q750J3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 28 family.|||Endoplasmic reticulum|||Heterodimer with ALG14 to form a functional enzyme.|||Involved in protein N-glycosylation. Essential for the second step of the dolichol-linked oligosaccharide pathway (By similarity). http://togogenome.org/gene/284811:AGOS_ADL164C ^@ http://purl.uniprot.org/uniprot/Q75AT4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AGL149C ^@ http://purl.uniprot.org/uniprot/Q750T8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR439C ^@ http://purl.uniprot.org/uniprot/Q752Y4 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/284811:AGOS_AFR207C ^@ http://purl.uniprot.org/uniprot/Q753W5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b560 family.|||Membrane|||The heme is bound between the two transmembrane subunits. http://togogenome.org/gene/284811:AGOS_AAL164C ^@ http://purl.uniprot.org/uniprot/Q75F95 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in ribosome assembly.|||Associates with pre-ribosomal particles.|||Belongs to the DEAD box helicase family. DDX27/DRS1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_ACL137C ^@ http://purl.uniprot.org/uniprot/Q75CQ6 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/284811:AGOS_ADR412C ^@ http://purl.uniprot.org/uniprot/Q758W6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/284811:AGOS_AEL100W ^@ http://purl.uniprot.org/uniprot/Q757W2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histone H4 and H2A. The NuA4 complex is also involved in DNA repair. Involved in cell cycle progression and meiosis (By similarity).|||Interacts with H3K4me3 and to a lesser extent with H3K4me2. Component of the NuA4 histone acetyltransferase complex.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/284811:AGOS_AGL057W ^@ http://purl.uniprot.org/uniprot/Q750K8 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Isocitrate lyase family.|||Can also use Mn(2+) ion. http://togogenome.org/gene/284811:AGOS_ACL134C ^@ http://purl.uniprot.org/uniprot/Q75CQ3 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) per subunit. http://togogenome.org/gene/284811:AGOS_AGR101C ^@ http://purl.uniprot.org/uniprot/Q74ZU7 ^@ Similarity ^@ Belongs to the RecA family. DMC1 subfamily. http://togogenome.org/gene/284811:AGOS_ADR144C ^@ http://purl.uniprot.org/uniprot/Q759X9 ^@ Similarity ^@ Belongs to the DNA/RNA non-specific endonuclease family. http://togogenome.org/gene/284811:AGOS_AFR124W ^@ http://purl.uniprot.org/uniprot/Q754E6 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/284811:AGOS_AFL148C ^@ http://purl.uniprot.org/uniprot/Q8J2M3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Homodimer.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved for instance in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function (By similarity).|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins. http://togogenome.org/gene/284811:AGOS_AFL080W ^@ http://purl.uniprot.org/uniprot/Q755A5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase required for 60S ribosomal subunit synthesis. Involved in efficient pre-rRNA processing, predominantly at site A3, which is necessary for the normal formation of 25S and 5.8S rRNAs (By similarity).|||Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AAR188W ^@ http://purl.uniprot.org/uniprot/Q75E92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/284811:AGOS_AER359W ^@ http://purl.uniprot.org/uniprot/Q756A8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/284811:AGOS_ADL338C ^@ http://purl.uniprot.org/uniprot/Q75BA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Endoplasmic reticulum membrane|||Participates in the formation of the lipid-linked precursor oligosaccharide for N-glycosylation. Involved in assembling the dolichol-pyrophosphate-GlcNAc(2)-Man(5) intermediate on the cytoplasmic surface of the ER (By similarity). http://togogenome.org/gene/284811:AGOS_AFR219C ^@ http://purl.uniprot.org/uniprot/Q753V6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DLT1 family.|||Membrane|||Required for growth under high-pressure and low-temperature conditions. http://togogenome.org/gene/284811:AGOS_ABR148W ^@ http://purl.uniprot.org/uniprot/Q75D76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/284811:AGOS_AFL055W ^@ http://purl.uniprot.org/uniprot/Q754X1 ^@ Activity Regulation|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. PAN2 subfamily.|||Binds 2 metal cations per subunit in the catalytic exonuclease domain.|||Catalytic subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein PAB1. PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. May also be involved in post-transcriptional maturation of mRNA poly(A) tails.|||Contains a pseudo-UCH domain. This ubiquitin C-terminal hydrolase (UCH)-like or ubiquitin specific protease (USP)-like domain is predicted to be catalytically inactive because it lacks the active site catalytic triad characteristic of thiol proteases, with residues at the equivalent structural positions that are incompatible with catalysis, and it cannot bind ubiquitin. It functions as a structural scaffold for intra- and intermolecular interactions in the complex.|||Cytoplasm|||Forms a heterotrimer with an asymmetric homodimer of the regulatory subunit PAN3 to form the poly(A)-nuclease (PAN) deadenylation complex.|||Positively regulated by the regulatory subunit PAN3.|||The linker, or PAN3 interaction domain (PID), between the WD40 repeats and the pseudo-UCH domain mediates interaction with PAN3. http://togogenome.org/gene/284811:AGOS_AAR100C ^@ http://purl.uniprot.org/uniprot/Q75EH9 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284811:AGOS_AFR642C ^@ http://purl.uniprot.org/uniprot/D8FGF0|||http://purl.uniprot.org/uniprot/Q755R1 ^@ Function|||Similarity ^@ Additional factor that functions in concert with eIF-2 and the initiator tRNA in directing the ribosome to the proper start site of translation.|||Belongs to the SUI1 family. http://togogenome.org/gene/284811:AGOS_ABR150C ^@ http://purl.uniprot.org/uniprot/Q75D73 ^@ Subcellular Location Annotation ^@ Nucleus|||kinetochore http://togogenome.org/gene/284811:AGOS_AGL296W ^@ http://purl.uniprot.org/uniprot/Q751K2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR672C ^@ http://purl.uniprot.org/uniprot/Q752A3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the timeless family.|||Component of the fork protection complex (FPC) consisting of TOF1 and CSM3.|||Forms a fork protection complex (FPC) with CSM3 and which is required for chromosome segregation during meiosis and DNA damage repair. FPC coordinates leading and lagging strand synthesis and moves with the replication fork. FPC stabilizes replication forks in a configuration that is recognized by replication checkpoint sensors (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AEL335C ^@ http://purl.uniprot.org/uniprot/Q758T7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MDM10 family.|||Component of the ER-mitochondria encounter structure (ERMES) or MDM complex, composed of MMM1, MDM10, MDM12 and MDM34. Associates with the mitochondrial outer membrane sorting assembly machinery SAM(core) complex.|||Component of the ERMES/MDM complex, which serves as a molecular tether to connect the endoplasmic reticulum and mitochondria. Components of this complex are involved in the control of mitochondrial shape and protein biogenesis and may function in phospholipid exchange. MDM10 is involved in the late assembly steps of the general translocase of the mitochondrial outer membrane (TOM complex). Functions in the TOM40-specific route of the assembly of outer membrane beta-barrel proteins, including the association of TOM40 with the receptor TOM22 and small TOM proteins. Can associate with the SAM(core) complex as well as the MDM12-MMM1 complex, both involved in late steps of the major beta-barrel assembly pathway, that is responsible for biogenesis of all outer membrane beta-barrel proteins. May act as a switch that shuttles between both complexes and channels precursor proteins into the TOM40-specific pathway. Plays a role in mitochondrial morphology and in the inheritance of mitochondria.|||Lacks alpha-helical transmembrane segments, suggesting that it resides in the membrane via beta-sheet conformations similar to those predicted for other outer membrane proteins and porin.|||Mitochondrion outer membrane http://togogenome.org/gene/284811:AGOS_AGR360C ^@ http://purl.uniprot.org/uniprot/Q74Z46 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284811:AGOS_ABL105W ^@ http://purl.uniprot.org/uniprot/Q75DX8 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284811:AGOS_AER036W ^@ http://purl.uniprot.org/uniprot/Q757H7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 14, 12 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RPB5 is part of the lower jaw surrounding the central large cleft and thought to grab the incoming DNA template. Seems to be the major component in this process (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_ADL168C ^@ http://purl.uniprot.org/uniprot/Q75AT8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/284811:AGOS_AMI003W ^@ http://purl.uniprot.org/uniprot/Q75G34 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of a catalytic core of 3 subunits and several supernumerary subunits. The complex exists as a monomer or a dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII).|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AER060W ^@ http://purl.uniprot.org/uniprot/Q757F3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP10 family.|||Involved in assembly of the mitochondrial F1-F0 complex.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AGL328C ^@ http://purl.uniprot.org/uniprot/Q751M5 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/284811:AGOS_AEL258W ^@ http://purl.uniprot.org/uniprot/Q758L9 ^@ Similarity ^@ Belongs to the AAA ATPase family. PCH2 subfamily. http://togogenome.org/gene/284811:AGOS_ACL028W ^@ http://purl.uniprot.org/uniprot/Q75CD7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/284811:AGOS_AER274W ^@ http://purl.uniprot.org/uniprot/Q756I7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR346W ^@ http://purl.uniprot.org/uniprot/Q753G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/284811:AGOS_ABR165W ^@ http://purl.uniprot.org/uniprot/Q75D58 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 17 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGL115W ^@ http://purl.uniprot.org/uniprot/Q750Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes. Regulates also the sphingolipid metabolism (By similarity). http://togogenome.org/gene/284811:AGOS_AGR187W ^@ http://purl.uniprot.org/uniprot/Q74ZL1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK2 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism. Adenylate kinase activity is critical for regulation of the phosphate utilization and the AMP de novo biosynthesis pathways.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Mitochondrion intermembrane space|||Monomer.|||cytosol http://togogenome.org/gene/284811:AGOS_ACL002C ^@ http://purl.uniprot.org/uniprot/Q75CB3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_AFR657C ^@ http://purl.uniprot.org/uniprot/Q752B8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-B family.|||Binds 1 [4Fe-4S] cluster.|||DNA polymerase II participates in chromosomal DNA replication.|||Heterotetramer. Consists of 4 subunits: POL2, DPB2, DPB3 and DPB4 (By similarity).|||Nucleus|||The CysA-type zinc finger is required for PCNA-binding.|||The CysB motif binds 1 4Fe-4S cluster and is required for the formation of polymerase complexes. http://togogenome.org/gene/284811:AGOS_ABR173C ^@ http://purl.uniprot.org/uniprot/Q75D50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ACR012C ^@ http://purl.uniprot.org/uniprot/Q75CA0 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/284811:AGOS_ADR203C ^@ http://purl.uniprot.org/uniprot/Q759S0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLD7 family.|||Nucleus|||Required for the proper initiation of DNA replication. Required for mitochondrial morphology (By similarity).|||spindle pole http://togogenome.org/gene/284811:AGOS_AFL199C ^@ http://purl.uniprot.org/uniprot/Q755L3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR135W ^@ http://purl.uniprot.org/uniprot/Q754D5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus|||Probably involved in transcription regulation via its interaction with the INO80 complex, a chromatin remodeling complex. http://togogenome.org/gene/284811:AGOS_ADR252W ^@ http://purl.uniprot.org/uniprot/Q759M4 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/284811:AGOS_AER167W ^@ http://purl.uniprot.org/uniprot/Q756T6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/284811:AGOS_AGR036W ^@ http://purl.uniprot.org/uniprot/Q750C1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/284811:AGOS_AER414W ^@ http://purl.uniprot.org/uniprot/Q755V4 ^@ Similarity ^@ Belongs to the XPG/RAD2 endonuclease family. http://togogenome.org/gene/284811:AGOS_AEL049W ^@ http://purl.uniprot.org/uniprot/Q757R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EDC3 family.|||P-body http://togogenome.org/gene/284811:AGOS_AGR003W ^@ http://purl.uniprot.org/uniprot/Q750F2 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/284811:AGOS_AEL151C ^@ http://purl.uniprot.org/uniprot/Q752J5 ^@ Miscellaneous|||Similarity ^@ Belongs to the universal ribosomal protein uS8 family.|||There are two genes for S22 in A.gossypii. http://togogenome.org/gene/284811:AGOS_AGR243W ^@ http://purl.uniprot.org/uniprot/Q74ZG4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cut8/STS1 family.|||Binds the proteasome.|||Cytoplasm|||Involved in ubiquitin-mediated protein degradation. Regulatory factor in the ubiquitin/proteasome pathway that controls the turnover of proteasome substrates. Targets proteasomes to the nucleus and facilitates the degradation of nuclear proteins (By similarity).|||Nucleus http://togogenome.org/gene/284811:AGOS_AFR221C ^@ http://purl.uniprot.org/uniprot/Q753V4 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/284811:AGOS_ACR091W ^@ http://purl.uniprot.org/uniprot/Q75C26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat CIA1 family.|||Cytoplasm|||Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins.|||Interacts with NAR1.|||Nucleus http://togogenome.org/gene/284811:AGOS_ADR077C ^@ http://purl.uniprot.org/uniprot/Q75A42 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. http://togogenome.org/gene/284811:AGOS_AER408W ^@ http://purl.uniprot.org/uniprot/Q755W0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in 40S ribosomal subunit biogenesis. Required for the processing and cleavage of 35S pre-rRNA at sites A0, A1, and A2, leading to mature 18S rRNA (By similarity).|||Belongs to the DEAD box helicase family. DDX48/FAL1 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284811:AGOS_AFL117C ^@ http://purl.uniprot.org/uniprot/Q755E0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/284811:AGOS_AEL229W ^@ http://purl.uniprot.org/uniprot/Q758J1 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/284811:AGOS_AAL182W ^@ http://purl.uniprot.org/uniprot/Q75FB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Nucleus http://togogenome.org/gene/284811:AGOS_AGR396W ^@ http://purl.uniprot.org/uniprot/Q74Z11 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/284811:AGOS_ABL017C ^@ http://purl.uniprot.org/uniprot/Q75DN4 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/284811:AGOS_AFL099W ^@ http://purl.uniprot.org/uniprot/Q755C2 ^@ Similarity ^@ Belongs to the TYW1 family. http://togogenome.org/gene/284811:AGOS_ADL156C ^@ http://purl.uniprot.org/uniprot/Q75AS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284811:AGOS_ADR368W ^@ http://purl.uniprot.org/uniprot/Q759A9 ^@ Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Homotetramer. http://togogenome.org/gene/284811:AGOS_AAL014C ^@ http://purl.uniprot.org/uniprot/O60029 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Mitochondrion inner membrane http://togogenome.org/gene/284811:AGOS_AFL106C ^@ http://purl.uniprot.org/uniprot/Q755C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion