http://togogenome.org/gene/284813:ECU02_0920 ^@ http://purl.uniprot.org/uniprot/Q8SWC6 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/284813:ECU01_1130 ^@ http://purl.uniprot.org/uniprot/Q8SQJ3 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Expression is low in meronts, but becomes induced in sporonts and spores.|||May be involved in the degradation of proteins for nutrient acquisition or possess a regulatory function by proteolytic activation of proproteins.|||extracellular space http://togogenome.org/gene/284813:ECU11_2110 ^@ http://purl.uniprot.org/uniprot/Q8STZ0 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_1700i ^@ http://purl.uniprot.org/uniprot/Q8SR00 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/284813:ECU06_0100 ^@ http://purl.uniprot.org/uniprot/Q8SVF2 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU06_1510 ^@ http://purl.uniprot.org/uniprot/Q8SV69 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/284813:ECU02_1550 ^@ http://purl.uniprot.org/uniprot/Q8ST67 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_0820i ^@ http://purl.uniprot.org/uniprot/Q8SS99 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Expressed in late sporogonial stages.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/284813:ECU09_1330 ^@ http://purl.uniprot.org/uniprot/Q8SQM0 ^@ Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the activator 1 small subunits family.|||Component of ATP-dependent clamp loader (RFC and RFC-like) complexes for DNA clamps. During a clamp loading circle, the RFC:clamp complex binds to DNA and the recognition of the double-stranded/single-stranded junction stimulates ATP hydrolysis by RFC. The complex presumably provides bipartite ATP sites in which one subunit supplies a catalytic site for hydrolysis of ATP bound to the neighboring subunit. Dissociation of RFC from the clamp leaves the clamp encircling DNA. Component of the replication factor C (RFC or activator 1) complex which acts during elongation of primed DNA templates by DNA polymerase delta and epsilon. RFC has an essential but redundant activity in sister chromatid cohesion establishment (By similarity).|||Component of the replication factor C (RFC) complex.|||Expressed in late sporogonial stages.|||Nucleus|||Present with 2760 molecules/cell in log phase SD medium. http://togogenome.org/gene/284813:ECU07_0010 ^@ http://purl.uniprot.org/uniprot/P0CT03 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU06_1290 ^@ http://purl.uniprot.org/uniprot/Q8SV84 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU09_0020 ^@ http://purl.uniprot.org/uniprot/Q8STY8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU06_0260 ^@ http://purl.uniprot.org/uniprot/Q8SRS9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/284813:ECU11_1400 ^@ http://purl.uniprot.org/uniprot/Q8SQU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB9 is part of the upper jaw surrounding the central large cleft and thought to grab the incoming DNA template. Involved in the regulation of transcription elongation (By similarity).|||nucleolus http://togogenome.org/gene/284813:ECU08_0110 ^@ http://purl.uniprot.org/uniprot/Q8SRG1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU04_0310 ^@ http://purl.uniprot.org/uniprot/Q8SS65 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the proteasome subunit S2 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU04_1110 ^@ http://purl.uniprot.org/uniprot/Q8SVS9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TOP6A family.|||Nucleus|||Required for meiotic recombination. Mediates DNA cleavage that forms the double-strand breaks (DSB) that initiate meiotic recombination (By similarity). http://togogenome.org/gene/284813:ECU01_0120 ^@ http://purl.uniprot.org/uniprot/Q8STB3 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_0090 ^@ http://purl.uniprot.org/uniprot/Q8SW78 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0800 ^@ http://purl.uniprot.org/uniprot/Q8SRC3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Fungal signal recognition particle consists of a 7S RNA molecule (scR1) and at least six protein subunits: SRP72, SRP68, SRP54, SEC65, SRP21 and SRP14.|||Signal-recognition-particle assembly has a crucial role in targeting secretory proteins to the rough endoplasmic reticulum membrane. It must be involved intimately in the translocation of a wide variety of protein substrates (By similarity). http://togogenome.org/gene/284813:ECU06_0490 ^@ http://purl.uniprot.org/uniprot/Q8SRR7 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/284813:ECU11_0790 ^@ http://purl.uniprot.org/uniprot/Q8SQX2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the COPII coat.|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules (By similarity).|||Cytoplasm|||Endoplasmic reticulum membrane|||Expressed in late sporogonial stages.|||Golgi apparatus membrane http://togogenome.org/gene/284813:ECU04_0080 ^@ http://purl.uniprot.org/uniprot/Q8ST97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0660 ^@ http://purl.uniprot.org/uniprot/Q8SR51 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/284813:ECU08_0860 ^@ http://purl.uniprot.org/uniprot/Q8SRC0 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284813:ECU08_1300 ^@ http://purl.uniprot.org/uniprot/Q8SRA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.|||Belongs to the ADP/ATP translocase tlc family.|||Cell membrane http://togogenome.org/gene/284813:ECU11_0970 ^@ http://purl.uniprot.org/uniprot/Q8SU45 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/284813:ECU01_1350 ^@ http://purl.uniprot.org/uniprot/Q8SWI1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284813:ECU04_1630 ^@ http://purl.uniprot.org/uniprot/Q8SVP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU02_1270 ^@ http://purl.uniprot.org/uniprot/Q8SSE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Essential role in pre-mRNA splicing. Also essential for entry into mitosis (G2/M progression) as well as for chromosome segregation during mitosis.|||Nucleus http://togogenome.org/gene/284813:ECU07_0560 ^@ http://purl.uniprot.org/uniprot/Q8SRK7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU07_1280 ^@ http://purl.uniprot.org/uniprot/Q8SRI2 ^@ Developmental Stage|||Function ^@ Expressed in late sporogonial stages.|||Involved in amino sugar synthesis (formation of chitin, supplies the amino sugars of asparagine-linked oligosaccharides of glycoproteins). http://togogenome.org/gene/284813:ECU03_0010 ^@ http://purl.uniprot.org/uniprot/Q8SW85 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_1410 ^@ http://purl.uniprot.org/uniprot/Q8SUB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU08_1970 ^@ http://purl.uniprot.org/uniprot/Q8SQI9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the AAA ATPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU09_1970 ^@ http://purl.uniprot.org/uniprot/Q8SQJ4 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/284813:ECU08_1820 ^@ http://purl.uniprot.org/uniprot/Q8SUJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus http://togogenome.org/gene/284813:ECU02_1130 ^@ http://purl.uniprot.org/uniprot/Q8SSE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PI3/PI4-kinase family. ATM subfamily.|||Nucleus|||Serine/threonine protein kinase which activates checkpoint signaling upon genotoxic stresses such as ionizing radiation (IR), ultraviolet light (UV), or DNA replication stalling, thereby acting as a DNA damage sensor. Recognizes the substrate consensus sequence [ST]-Q. Recruited to DNA lesions in order to initiate the DNA repair by homologous recombination. Phosphorylates histone H2A to form H2AS128ph (gamma-H2A) at sites of DNA damage, also involved in the regulation of DNA damage response mechanism. Required for cell growth and meiotic recombination (By similarity). http://togogenome.org/gene/284813:ECU10_0070 ^@ http://purl.uniprot.org/uniprot/Q8ST62 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL29 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_0370 ^@ http://purl.uniprot.org/uniprot/Q8SV34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Membrane http://togogenome.org/gene/284813:ECU05_0270 ^@ http://purl.uniprot.org/uniprot/Q8SS04 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/284813:ECU08_1070 ^@ http://purl.uniprot.org/uniprot/Q8STD9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/284813:ECU10_1430 ^@ http://purl.uniprot.org/uniprot/Q8SR12 ^@ Similarity ^@ Belongs to the acetyltransferase family. GCN5 subfamily. http://togogenome.org/gene/284813:ECU02_0740i ^@ http://purl.uniprot.org/uniprot/Q8SWD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family.|||Cytoplasm|||Nucleus|||Ubiquitin exists either covalently attached to another protein, or free (unanchored). When covalently bound, it is conjugated to target proteins via an isopeptide bond either as a monomer (monoubiquitin), a polymer linked via different Lys residues of the ubiquitin (polyubiquitin chains) or a linear polymer linked via the initiator Met of the ubiquitin (linear polyubiquitin chains). Polyubiquitin chains, when attached to a target protein, have different functions depending on the Lys residue of the ubiquitin that is linked: Lys-6-linked may be involved in DNA repair; Lys-11-linked is involved in ERAD (endoplasmic reticulum-associated degradation) and in cell-cycle regulation; Lys-29-linked is involved in lysosomal degradation; Lys-33-linked is involved in kinase modification; Lys-48-linked is involved in protein degradation via the proteasome; Lys-63-linked is involved in endocytosis, and DNA-damage responses. Linear polymer chains formed via attachment by the initiator Met lead to cell signaling. Ubiquitin is usually conjugated to Lys residues of target proteins, however, in rare cases, conjugation to Cys or Ser residues has been observed. When polyubiquitin is free (unanchored-polyubiquitin), it also has distinct roles, such as in activation of protein kinases, and in signaling (By similarity). http://togogenome.org/gene/284813:ECU11_1600 ^@ http://purl.uniprot.org/uniprot/Q8SU14 ^@ Similarity ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family. http://togogenome.org/gene/284813:ECU06_0650 ^@ http://purl.uniprot.org/uniprot/Q8SVC2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Cytoplasm|||Expressed in late sporogonial stages.|||Monomer. http://togogenome.org/gene/284813:ECU08_0280 ^@ http://purl.uniprot.org/uniprot/Q8SRF1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU08_1500 ^@ http://purl.uniprot.org/uniprot/Q8SUL8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284813:ECU07_0540 ^@ http://purl.uniprot.org/uniprot/Q8SV24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284813:ECU10_1130 ^@ http://purl.uniprot.org/uniprot/Q8SR28 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC2 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Component of the origin recognition complex (ORC).|||Nucleus http://togogenome.org/gene/284813:ECU06_1670 ^@ http://purl.uniprot.org/uniprot/Q8SV58 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU02_0050 ^@ http://purl.uniprot.org/uniprot/Q8SWH7 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_0760 ^@ http://purl.uniprot.org/uniprot/Q8SRK0 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Expressed in late sporogonial stages.|||Homodimer.|||Probably involved in mitosomal protein import. http://togogenome.org/gene/284813:ECU03_1620 ^@ http://purl.uniprot.org/uniprot/Q8SVY8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0310 ^@ http://purl.uniprot.org/uniprot/Q8SR70 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/284813:ECU01_1370 ^@ http://purl.uniprot.org/uniprot/Q8SSI8 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Component of the septin complex.|||Expressed in late sporogonial stages.|||Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity). http://togogenome.org/gene/284813:ECU09_0330 ^@ http://purl.uniprot.org/uniprot/Q8SQP9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU11_1520 ^@ http://purl.uniprot.org/uniprot/Q8SU19 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Forms a complex with TRM82.|||Nucleus http://togogenome.org/gene/284813:ECU07_1320 ^@ http://purl.uniprot.org/uniprot/Q8SUX1 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/284813:ECU03_1330 ^@ http://purl.uniprot.org/uniprot/Q8SS82 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284813:ECU05_1640 ^@ http://purl.uniprot.org/uniprot/Q8STF1 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU01_1480 ^@ http://purl.uniprot.org/uniprot/Q8ST53 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_1050 ^@ http://purl.uniprot.org/uniprot/Q8SW25 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU01_0740i ^@ http://purl.uniprot.org/uniprot/O96720 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/284813:ECU03_1000 ^@ http://purl.uniprot.org/uniprot/Q8SW29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/284813:ECU07_1570 ^@ http://purl.uniprot.org/uniprot/Q8SRH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU02_0450 ^@ http://purl.uniprot.org/uniprot/Q8SSH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. TFIIA in a complex with TBP mediates transcriptional activity. http://togogenome.org/gene/284813:ECU01_1500 ^@ http://purl.uniprot.org/uniprot/Q8STB5 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_0080 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU06_1360 ^@ http://purl.uniprot.org/uniprot/Q8SRN6 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/284813:ECU03_1610 ^@ http://purl.uniprot.org/uniprot/Q8SVY9 ^@ Developmental Stage|||Similarity ^@ Belongs to the LEA type 1 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU11_2030 ^@ http://purl.uniprot.org/uniprot/Q8SQQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STE12 transcription factor family.|||Nucleus http://togogenome.org/gene/284813:ECU06_1230 ^@ http://purl.uniprot.org/uniprot/Q8SV88 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/284813:ECU02_0720 ^@ http://purl.uniprot.org/uniprot/Q8SSG3 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Expressed in late sporogonial stages.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/284813:ECU09_0100 ^@ http://purl.uniprot.org/uniprot/Q8STY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BRE1 family.|||Nucleus http://togogenome.org/gene/284813:ECU09_1310 ^@ http://purl.uniprot.org/uniprot/Q8SQM1 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/284813:ECU05_1270 ^@ http://purl.uniprot.org/uniprot/Q8SRV1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/284813:ECU09_1000 ^@ http://purl.uniprot.org/uniprot/Q8SQI3 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL3 family.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_1360 ^@ http://purl.uniprot.org/uniprot/Q8SW07 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/284813:ECU09_0940 ^@ http://purl.uniprot.org/uniprot/Q8SQN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Golgi apparatus membrane|||Membrane|||Nonessential protein required for the fusion of transport vesicles derived from the endocytic pathway with the Golgi complex. http://togogenome.org/gene/284813:ECU01_1420 ^@ http://purl.uniprot.org/uniprot/O62585 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Cytoplasm|||Homotetramer.|||Interconversion of serine and glycine. http://togogenome.org/gene/284813:ECU05_1650 ^@ http://purl.uniprot.org/uniprot/P0CT00 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_0840 ^@ http://purl.uniprot.org/uniprot/Q8SW39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/284813:ECU08_1120 ^@ http://purl.uniprot.org/uniprot/Q8SRA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU11_1260 ^@ http://purl.uniprot.org/uniprot/Q8SQV0 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/284813:ECU08_0350i ^@ http://purl.uniprot.org/uniprot/Q8SRE7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/284813:ECU05_1060 ^@ http://purl.uniprot.org/uniprot/Q8SRV8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU01_1470 ^@ http://purl.uniprot.org/uniprot/Q8SQI6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU02_0460 ^@ http://purl.uniprot.org/uniprot/Q8SWE7 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/284813:ECU06_0770 ^@ http://purl.uniprot.org/uniprot/Q8SRQ9 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/284813:ECU04_1020 ^@ http://purl.uniprot.org/uniprot/Q8SS33 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU08_2080 ^@ http://purl.uniprot.org/uniprot/Q8SUH8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU08_2070 ^@ http://purl.uniprot.org/uniprot/Q8SUH9 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU05_0590 ^@ http://purl.uniprot.org/uniprot/Q8SVK8 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU02_0530 ^@ http://purl.uniprot.org/uniprot/Q8SWE3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU03_0470 ^@ http://purl.uniprot.org/uniprot/Q8SSB5 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/284813:ECU10_0640 ^@ http://purl.uniprot.org/uniprot/Q8SR52 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/284813:ECU11_0840 ^@ http://purl.uniprot.org/uniprot/Q8SQW9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284813:ECU07_0880 ^@ http://purl.uniprot.org/uniprot/Q8SV04 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/284813:ECU11_0800 ^@ http://purl.uniprot.org/uniprot/Q8SQX1 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/284813:ECU09_0390 ^@ http://purl.uniprot.org/uniprot/Q8STV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/284813:ECU01_0920 ^@ http://purl.uniprot.org/uniprot/Q8SSK9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS12 family. http://togogenome.org/gene/284813:ECU05_1130 ^@ http://purl.uniprot.org/uniprot/Q8SVI2 ^@ Similarity ^@ Belongs to the Clp1 family. NOL9/GRC3 subfamily. http://togogenome.org/gene/284813:ECU08_0490 ^@ http://purl.uniprot.org/uniprot/Q8SRE0 ^@ Cofactor|||Developmental Stage|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_1250 ^@ http://purl.uniprot.org/uniprot/Q8SRA6 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/284813:ECU06_0320 ^@ http://purl.uniprot.org/uniprot/Q8SRS6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of 14, 12 and 17 subunits, respectively.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and a small RNAs, such as 5S rRNA and tRNAs, respectively. Pol II is the central component of the basal RNA polymerase II transcription machinery. Pols are composed of mobile elements that move relative to each other. In Pol II, RBP10 is part of the core element with the central large cleft (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU05_1660 ^@ http://purl.uniprot.org/uniprot/Q8STG4 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_0760 ^@ http://purl.uniprot.org/uniprot/Q8SQN6 ^@ Function ^@ Possesses 5'->3' exoribonuclease activity. Required for the processing of nuclear mRNA and rRNA precursors. May promote termination of transcription by RNA polymerase II. http://togogenome.org/gene/284813:ECU03_0710 ^@ http://purl.uniprot.org/uniprot/Q8SSA2 ^@ Developmental Stage|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0150 ^@ http://purl.uniprot.org/uniprot/Q8SSD1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TPT transporter family. SLC35D subfamily.|||Cytoplasmic vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homooligomer.|||Involved in the import of GDP-mannose from the cytoplasm into the Golgi lumen.|||Membrane http://togogenome.org/gene/284813:ECU04_1250 ^@ http://purl.uniprot.org/uniprot/Q8SS21 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/284813:ECU05_0990 ^@ http://purl.uniprot.org/uniprot/Q8SRW2 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/284813:ECU04_1660 ^@ http://purl.uniprot.org/uniprot/Q8SVP3 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_1860 ^@ http://purl.uniprot.org/uniprot/Q8ST89 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU06_1710 ^@ http://purl.uniprot.org/uniprot/Q8STE8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_0650 ^@ http://purl.uniprot.org/uniprot/Q8SV15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284813:ECU05_1430 ^@ http://purl.uniprot.org/uniprot/Q8SVG7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284813:ECU07_1090 ^@ http://purl.uniprot.org/uniprot/Q8SUY7 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_0590 ^@ http://purl.uniprot.org/uniprot/Q8SR56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PI3/PI4-kinase family.|||Component of the autophagy-specific VPS34 PI3-kinase complex I composed; and of the VPS34 PI3-kinase complex II.|||Endosome membrane|||Phosphatidylinositol 3-kinase required for cytoplasm to vacuole transport (Cvt) and autophagy as a part of the autophagy-specific VPS34 PI3-kinase complex I. Also involved in endosome-to-Golgi retrograde transport as part of the VPS34 PI3-kinase complex II (By similarity).|||trans-Golgi network membrane http://togogenome.org/gene/284813:ECU11_0270 ^@ http://purl.uniprot.org/uniprot/Q8SU83 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG9 family.|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Phospholipid scramblase involved in autophagy. Cycles between the preautophagosomal structure/phagophore assembly site (PAS) and the cytoplasmic vesicle pool and supplies membrane for the growing autophagosome. Lipid scramblase activity plays a key role in preautophagosomal structure/phagophore assembly by distributing the phospholipids that arrive through ATG2 from the cytoplasmic to the luminal leaflet of the bilayer, thereby driving autophagosomal membrane expansion.|||Preautophagosomal structure membrane http://togogenome.org/gene/284813:ECU01_1360 ^@ http://purl.uniprot.org/uniprot/O96722 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Non-catalytic component of the H/ACA small nucleolar ribonucleoprotein (H/ACA snoRNP), which catalyzes pseudouridylation of rRNA and is required for ribosome biogenesis. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ('psi') residues may serve to stabilize the conformation of rRNAs. The H/ACA snoRNP complex also mediates pseudouridylation of other types of RNAs. The H/ACA snoRNP complex mediates pseudouridylation at position 93 in U2 snRNA.|||nucleolus http://togogenome.org/gene/284813:ECU03_0390 ^@ http://purl.uniprot.org/uniprot/Q8SSB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU11_1390 ^@ http://purl.uniprot.org/uniprot/Q8SU23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/284813:ECU09_1690 ^@ http://purl.uniprot.org/uniprot/Q8SQK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NUF2 family.|||Component of the NDC80 complex, which consists of at least NDC80 and NUF2.|||Nucleus|||kinetochore http://togogenome.org/gene/284813:ECU08_0400 ^@ http://purl.uniprot.org/uniprot/Q8SRE3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/284813:ECU11_1240 ^@ http://purl.uniprot.org/uniprot/Q8SU29 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_1820 ^@ http://purl.uniprot.org/uniprot/Q8SU95 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU06_0480 ^@ http://purl.uniprot.org/uniprot/Q8SVD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/284813:ECU09_0480 ^@ http://purl.uniprot.org/uniprot/Q8SQP2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU05_1120i ^@ http://purl.uniprot.org/uniprot/Q8SRV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284813:ECU06_0400 ^@ http://purl.uniprot.org/uniprot/Q8SVD9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. BUD32 family.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. BUD32 has ATPase activity in the context of the EKC/KEOPS complex and likely plays a supporting role to the catalytic subunit KAE1. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus|||This protein is considered an atypical serine/threonine kinase, because it lacks the conventional structural elements necessary for the substrate recognition as well as a lysine residue that in all other serine/threonine kinases participates in the catalytic event (By similarity). BUD32 has protein kinase activity in vitro, but in the context of the EKC/KEOPS complex, the catalytic subunit KAE1 switches the activity of BUD32 from kinase into ATPase (By similarity).|||telomere http://togogenome.org/gene/284813:ECU06_1410 ^@ http://purl.uniprot.org/uniprot/Q8SV74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Component of the GINS complex which is a heterotetramer of SLD5, PSF1, PSF2 and PSF3.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/284813:ECU06_1445 ^@ http://purl.uniprot.org/uniprot/Q8SRN2 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS26 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_0180 ^@ http://purl.uniprot.org/uniprot/Q8SQJ1 ^@ Similarity ^@ Belongs to the histidine acid phosphatase family. http://togogenome.org/gene/284813:ECU08_0320 ^@ http://purl.uniprot.org/uniprot/Q8SRE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284813:ECU08_1380 ^@ http://purl.uniprot.org/uniprot/Q8SUM8 ^@ Caution|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutaredoxin family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins (By similarity).|||May be inactive since it lacks one cysteine involved the redox-active disulfide bond. http://togogenome.org/gene/284813:ECU07_1760 ^@ http://purl.uniprot.org/uniprot/Q8SRG4 ^@ Similarity ^@ Belongs to the acetyltransferase family. GNA1 subfamily. http://togogenome.org/gene/284813:ECU03_1600 ^@ http://purl.uniprot.org/uniprot/Q8SVZ0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YAF9 family.|||Component of the SWR1 chromatin-remodeling complex and of the NuA4 histone acetyltransferase complex.|||Component of the SWR1 complex which mediates the ATP-dependent exchange of histone H2A for an H2A variant leading to transcriptional regulation of selected genes by chromatin remodeling. Component of the NuA4 histone acetyltransferase complex which is involved in transcriptional activation of selected genes principally by acetylation of nucleosomal histones H4 and H2A. The NuA4 complex is also involved in DNA repair. Yaf9 may also be required for viability in conditions in which the structural integrity of the spindle is compromised.|||Cytoplasm|||Nucleus|||The coiled-coil domain is required for assembly into the NuA4 complex. http://togogenome.org/gene/284813:ECU10_0040 ^@ http://purl.uniprot.org/uniprot/Q8ST89 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_0600 ^@ http://purl.uniprot.org/uniprot/Q8SSL9 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU05_0600 ^@ http://purl.uniprot.org/uniprot/Q8SRY5 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU11_1210 ^@ http://purl.uniprot.org/uniprot/Q8SU32 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWP7 family.|||Expressed in late sporogonial stages.|||Spore wall http://togogenome.org/gene/284813:ECU09_0250 ^@ http://purl.uniprot.org/uniprot/Q8STX1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/284813:ECU11_1990 ^@ http://purl.uniprot.org/uniprot/Q8SQR1 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284813:ECU02_0580 ^@ http://purl.uniprot.org/uniprot/Q8SSH0 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||Thiolesterase that catalyzes the hydrolysis of S-D-lactoyl-glutathione to form glutathione and D-lactic acid. http://togogenome.org/gene/284813:ECU06_1690 ^@ http://purl.uniprot.org/uniprot/Q8STJ4 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_1380 ^@ http://purl.uniprot.org/uniprot/Q8SQL6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as an adapter for the XPO1/CRM1-mediated export of the 60S ribosomal subunit.|||Belongs to the NMD3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU04_0530 ^@ http://purl.uniprot.org/uniprot/Q8SVW0 ^@ Similarity ^@ Belongs to the HSF family. http://togogenome.org/gene/284813:ECU07_0490 ^@ http://purl.uniprot.org/uniprot/Q8SRK9 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/284813:ECU06_0500 ^@ http://purl.uniprot.org/uniprot/Q8SVD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU08_1870 ^@ http://purl.uniprot.org/uniprot/Q8SR88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU05_0860 ^@ http://purl.uniprot.org/uniprot/Q8SRX1 ^@ Similarity ^@ Belongs to the 6-phosphogluconate dehydrogenase family. http://togogenome.org/gene/284813:ECU04_1140 ^@ http://purl.uniprot.org/uniprot/Q8SS27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU11_0830 ^@ http://purl.uniprot.org/uniprot/Q8SU50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF10 family.|||Nucleus http://togogenome.org/gene/284813:ECU06_0270 ^@ http://purl.uniprot.org/uniprot/Q8SVE4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/284813:ECU06_1490 ^@ http://purl.uniprot.org/uniprot/Q8SV71 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU10_1120 ^@ http://purl.uniprot.org/uniprot/Q8SR29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF6 family.|||Nucleus http://togogenome.org/gene/284813:ECU11_0850 ^@ http://purl.uniprot.org/uniprot/Q8SQW8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/284813:ECU08_0600i ^@ http://purl.uniprot.org/uniprot/Q8SRD7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/284813:ECU03_0520 ^@ http://purl.uniprot.org/uniprot/Q8SSB1 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_1500 ^@ http://purl.uniprot.org/uniprot/Q8SVG2 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284813:ECU11_0180 ^@ http://purl.uniprot.org/uniprot/Q8SQZ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily.|||Cytoplasm|||Negative regulator of the cell cycle acting downstream of the cAMP-dependent protein kinase. Part of a glucose-sensing system involved in growth control in response to glucose availability (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU03_0610 ^@ http://purl.uniprot.org/uniprot/Q8SW50 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU11_0280 ^@ http://purl.uniprot.org/uniprot/Q8SU82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU11_1170 ^@ http://purl.uniprot.org/uniprot/Q8SU33 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284813:ECU09_1860 ^@ http://purl.uniprot.org/uniprot/Q8STL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU07_0380 ^@ http://purl.uniprot.org/uniprot/Q8SRL4 ^@ Similarity ^@ Belongs to the REXO1/REXO3 family. http://togogenome.org/gene/284813:ECU06_0010 ^@ http://purl.uniprot.org/uniprot/Q8STE8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU11_1280i ^@ http://purl.uniprot.org/uniprot/Q8SQU9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).|||Endomembrane system|||Expressed in late sporogonial stages.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||Vacuole membrane http://togogenome.org/gene/284813:ECU06_1620 ^@ http://purl.uniprot.org/uniprot/Q8SV63 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU04_1190 ^@ http://purl.uniprot.org/uniprot/Q8SVS6 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/284813:ECU05_1440 ^@ http://purl.uniprot.org/uniprot/Q8SRU2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the splicing factor SR family.|||Expressed in late sporogonial stages.|||Nucleus|||Plays a role in splicing. http://togogenome.org/gene/284813:ECU03_0110 ^@ http://purl.uniprot.org/uniprot/Q8SW76 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU04_1100 ^@ http://purl.uniprot.org/uniprot/Q8SS29 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Component of the eukaryotic elongation factor 1 complex (eEF1).|||Cytoplasm|||Expressed in late sporogonial stages.|||GTP-binding component of the eukaryotic elongation factor 1 complex (eEF1). In its active GTP-bound form, binds to and delivers aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. In the presence of a correct codon-anticodon match between the aminoacyl-tRNA and the A-site codon of the ribosome-bound mRNA, the ribosome acts as a GTPase activator and the GTP is hydrolyzed. The inactive GDP-bound form leaves the ribosome and must be recycled by its guanine nucleotide exchange factor (GEF) (eEF1B subcomplex) before binding another molecule of aminoacyl-tRNA. Required for nuclear export of aminoacyl-tRNAs. May also be involved in translational quality control by targeting cotranslationally damaged proteins to the proteasome (By similarity). http://togogenome.org/gene/284813:ECU06_0430 ^@ http://purl.uniprot.org/uniprot/Q8SRS0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dUTPase family.|||Homotrimer.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/284813:ECU02_0550 ^@ http://purl.uniprot.org/uniprot/Q8SSH1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/284813:ECU01_0140 ^@ http://purl.uniprot.org/uniprot/Q8SQI6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU05_1530 ^@ http://purl.uniprot.org/uniprot/Q8SRT8 ^@ Similarity ^@ Belongs to the activator 1 large subunit family. http://togogenome.org/gene/284813:ECU05_0080 ^@ http://purl.uniprot.org/uniprot/Q8SVN7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU07_1790 ^@ http://purl.uniprot.org/uniprot/Q8SUU4 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/284813:ECU06_1250 ^@ http://purl.uniprot.org/uniprot/Q8SRN8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX54/DBP10 subfamily.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284813:ECU09_0395 ^@ http://purl.uniprot.org/uniprot/Q8SQP8 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL39 family.|||Interacts with YIH1. http://togogenome.org/gene/284813:ECU09_0010 ^@ http://purl.uniprot.org/uniprot/Q8STY9 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_0300 ^@ http://purl.uniprot.org/uniprot/Q8SW66 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SKP1 family.|||Component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes.|||Essential component of the SCF (SKP1-CUL1-F-box protein) E3 ubiquitin ligase complexes, which mediate the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/284813:ECU07_0740 ^@ http://purl.uniprot.org/uniprot/Q8SRK2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins contain two tandem repeats each containing three membrane-spanning domains and a pore-forming loop with the signature motif Asn-Pro-Ala (NPA). In microsporidia, the second signature motif differs slightly and is Asn-Pro-Gly (NPG).|||Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Water channel required to facilitate the transport of water across membranes. Involved in osmotolerance. http://togogenome.org/gene/284813:ECU02_1160 ^@ http://purl.uniprot.org/uniprot/Q8SWB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/284813:ECU01_1080 ^@ http://purl.uniprot.org/uniprot/Q8SSK0 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/284813:ECU04_1700 ^@ http://purl.uniprot.org/uniprot/Q8ST35 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU04_1240 ^@ http://purl.uniprot.org/uniprot/Q8SVS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/284813:ECU10_1110 ^@ http://purl.uniprot.org/uniprot/Q8SR30 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA. Appears to be an important mediator of the multiple roles of the poly(A) tail in mRNA biogenesis, stability and translation.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus http://togogenome.org/gene/284813:ECU11_1430 ^@ http://purl.uniprot.org/uniprot/Q8SQT9 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/284813:ECU08_0850 ^@ http://purl.uniprot.org/uniprot/Q8SUQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/284813:ECU01_0200 ^@ http://purl.uniprot.org/uniprot/Q8SQI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Membrane http://togogenome.org/gene/284813:ECU04_0110 ^@ http://purl.uniprot.org/uniprot/Q8SVY5 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU06_0090 ^@ http://purl.uniprot.org/uniprot/Q8SVF3 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU06_0340 ^@ http://purl.uniprot.org/uniprot/Q8SRS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284813:ECU05_1510 ^@ http://purl.uniprot.org/uniprot/Q8SRU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CK2 subfamily.|||Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer composed of two alpha chains, one beta chain and one beta' chain. http://togogenome.org/gene/284813:ECU11_1970 ^@ http://purl.uniprot.org/uniprot/Q8STZ5 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/284813:ECU02_1250 ^@ http://purl.uniprot.org/uniprot/Q8SSE1 ^@ Similarity ^@ Belongs to the TAF11 family. http://togogenome.org/gene/284813:ECU10_1810 ^@ http://purl.uniprot.org/uniprot/Q8SU96 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU04_1220 ^@ http://purl.uniprot.org/uniprot/Q8SS22 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/284813:ECU09_1190 ^@ http://purl.uniprot.org/uniprot/Q8SQM6 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/284813:ECU07_0090 ^@ http://purl.uniprot.org/uniprot/Q8SRM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/284813:ECU07_0190 ^@ http://purl.uniprot.org/uniprot/Q8SRM0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284813:ECU11_0960 ^@ http://purl.uniprot.org/uniprot/Q8SQW2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Catalytic subunit of the CTDK-I complex, which hyperphosphorylates the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit. Involved in RNA polymerase II transcriptional elongation and pre-mRNA 3'-end processing (By similarity).|||Component of the CTDK-I complex.|||nucleolus http://togogenome.org/gene/284813:ECU07_1270 ^@ http://purl.uniprot.org/uniprot/Q8SRI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily.|||Cytoplasm|||May play a role in the initiation and completion of mitosis.|||Nucleus http://togogenome.org/gene/284813:ECU02_0810 ^@ http://purl.uniprot.org/uniprot/Q8SSF6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/284813:ECU08_1280 ^@ http://purl.uniprot.org/uniprot/Q8SUN2 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_0700 ^@ http://purl.uniprot.org/uniprot/O96719 ^@ Function|||Similarity|||Subunit ^@ As a subunit of eukaryotic initiation factor 2 (eIF-2), involved in the early steps of protein synthesis. In the presence of GTP, eIF-2 forms a ternary complex with initiator tRNA Met-tRNAi and then recruits the 40S ribosomal complex and initiation factors eIF-1, eIF-1A and eIF-3 to form the 43S pre-initiation complex (43S PIC), a step that determines the rate of protein translation. The 43S PIC binds to mRNA and scans downstream to the initiation codon, where it forms a 48S initiation complex by codon-anticodon base pairing. This leads to the displacement of eIF-1 to allow GTPase-activating protein (GAP) eIF-5-mediated hydrolysis of eIF2-bound GTP. Hydrolysis of GTP and release of Pi, which makes GTP hydrolysis irreversible, causes the release of the eIF-2-GDP binary complex from the 40S subunit, an event that is essential for the subsequent joining of the 60S ribosomal subunit to form an elongation-competent 80S ribosome. In order for eIF-2 to recycle and catalyze another round of initiation, the GDP bound to eIF-2 must be exchanged with GTP by way of a reaction catalyzed by GDP-GTP exchange factor (GEF) eIF-2B.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Eukaryotic translation initiation factor 2 (eIF-2) is a heterotrimeric G-protein composed of an alpha, a beta and a gamma subunit. The factors eIF-1, eIF-2, eIF-3, TIF5/eIF-5 and methionyl-tRNAi form a multifactor complex (MFC) that may bind to the 40S ribosome. http://togogenome.org/gene/284813:ECU04_1580 ^@ http://purl.uniprot.org/uniprot/Q8SVQ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU07_1660 ^@ http://purl.uniprot.org/uniprot/Q8SRG9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284813:ECU05_1140 ^@ http://purl.uniprot.org/uniprot/Q8SRV6 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284813:ECU11_1770 ^@ http://purl.uniprot.org/uniprot/Q8SQS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe-S) clusters in mitosomes.|||Mitosome http://togogenome.org/gene/284813:ECU08_0550 ^@ http://purl.uniprot.org/uniprot/Q8SRD8 ^@ Developmental Stage|||Similarity|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Expressed in late sporogonial stages.|||Monomer. http://togogenome.org/gene/284813:ECU09_0690 ^@ http://purl.uniprot.org/uniprot/Q8STT8 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/284813:ECU08_2060 ^@ http://purl.uniprot.org/uniprot/Q8SUI0 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU04_0350 ^@ http://purl.uniprot.org/uniprot/Q8SS63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/284813:ECU05_1320 ^@ http://purl.uniprot.org/uniprot/Q8SRU8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/284813:ECU07_0040 ^@ http://purl.uniprot.org/uniprot/P0CS98|||http://purl.uniprot.org/uniprot/P0CS99 ^@ Developmental Stage|||Similarity ^@ Belongs to the UPF0328 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU06_0530 ^@ http://purl.uniprot.org/uniprot/Q8SVD1 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/284813:ECU04_0170 ^@ http://purl.uniprot.org/uniprot/Q8SVY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane|||May function both as a monomer and a homodimer. http://togogenome.org/gene/284813:ECU06_1460 ^@ http://purl.uniprot.org/uniprot/Q8SRN0 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284813:ECU11_0890 ^@ http://purl.uniprot.org/uniprot/Q8SQW5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU06_1380 ^@ http://purl.uniprot.org/uniprot/Q8SRN5 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/284813:ECU04_1160 ^@ http://purl.uniprot.org/uniprot/Q8SS26 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/284813:ECU07_1010 ^@ http://purl.uniprot.org/uniprot/Q8SRJ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/284813:ECU08_1040 ^@ http://purl.uniprot.org/uniprot/Q8STD9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/284813:ECU09_1950 ^@ http://purl.uniprot.org/uniprot/Q8STK5 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU03_0170 ^@ http://purl.uniprot.org/uniprot/Q8SW72 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU10_0220 ^@ http://purl.uniprot.org/uniprot/Q8SR77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/284813:ECU05_0310 ^@ http://purl.uniprot.org/uniprot/Q8SRZ9 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/284813:ECU03_1070 ^@ http://purl.uniprot.org/uniprot/Q8SW23 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFIIA subunit 1 family.|||Expressed in late sporogonial stages.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation.|||TFIIA is a heterodimer of the large subunit and the small subunit gamma. http://togogenome.org/gene/284813:ECU08_1780 ^@ http://purl.uniprot.org/uniprot/Q8SR91 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/284813:ECU08_0410 ^@ http://purl.uniprot.org/uniprot/Q8SRE2 ^@ Caution|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Expressed in late sporogonial stages.|||Monoubiquitinated to form H2BK123ub1. H2BK123ub1 gives a specific tag for epigenetic transcriptional activation and is also prerequisite for H3K4me and H3K79me formation (By similarity).|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H2BK123ub1 = monoubiquitinated Lys-122. http://togogenome.org/gene/284813:ECU11_0870 ^@ http://purl.uniprot.org/uniprot/Q8SQW6 ^@ Developmental Stage|||Similarity ^@ Belongs to the cytidylyltransferase family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU09_1640 ^@ http://purl.uniprot.org/uniprot/Q8SQK9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent RNA helicase involved in mRNA turnover, and more specifically in mRNA decapping. Is involved in G1/S DNA-damage checkpoint recovery, probably through the regulation of the translational status of a subset of mRNAs. May also have a role in translation and mRNA nuclear export (By similarity).|||Belongs to the DEAD box helicase family. DDX6/DHH1 subfamily.|||P-body|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284813:ECU10_0320 ^@ http://purl.uniprot.org/uniprot/Q8SUH1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU07_0610i ^@ http://purl.uniprot.org/uniprot/Q8SRK6 ^@ Cofactor|||Developmental Stage|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Expressed in late sporogonial stages.|||Homodimer. Forms a complex with MRE11.|||Involved in DNA double-strand break repair (DSBR). The RAD50/MRE11 complex possesses single-strand endonuclease activity and ATP-dependent double-strand-specific exonuclease activity. RAD50 provides ATP-dependent control of MRE11 by unwinding and/or repositioning DNA ends into the MRE11 active site (By similarity).|||The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/284813:ECU10_1200i ^@ http://purl.uniprot.org/uniprot/Q8SR24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Regulatory subunit of casein kinase II/CK2 (By similarity). As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Regulatory subunit of casein kinase II/CK2. As part of the kinase complex regulates the basal catalytic activity of the alpha subunit a constitutively active serine/threonine-protein kinase that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284813:ECU02_1200 ^@ http://purl.uniprot.org/uniprot/Q8SWA6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU08_0770 ^@ http://purl.uniprot.org/uniprot/Q8SRC4 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/284813:ECU03_0270 ^@ http://purl.uniprot.org/uniprot/Q8SSC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284813:ECU10_0260 ^@ http://purl.uniprot.org/uniprot/Q8SR74 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/284813:ECU02_1300 ^@ http://purl.uniprot.org/uniprot/Q8SSD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/284813:ECU11_1980 ^@ http://purl.uniprot.org/uniprot/Q8SQR2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.|||Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU11_1760 ^@ http://purl.uniprot.org/uniprot/Q8SQS3 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/284813:ECU11_0470 ^@ http://purl.uniprot.org/uniprot/Q8SQY6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU04_0630 ^@ http://purl.uniprot.org/uniprot/Q8SS54 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284813:ECU09_0740 ^@ http://purl.uniprot.org/uniprot/Q8STT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU02_0200 ^@ http://purl.uniprot.org/uniprot/Q8SWG3 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/284813:ECU05_1020 ^@ http://purl.uniprot.org/uniprot/Q8SRW0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/284813:ECU03_1220 ^@ http://purl.uniprot.org/uniprot/Q8SQI3 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL3 family.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_0300 ^@ http://purl.uniprot.org/uniprot/Q8SR71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Sterol O-acyltransferase that catalyzes the formation of stery esters. http://togogenome.org/gene/284813:ECU10_1040 ^@ http://purl.uniprot.org/uniprot/Q8SR34 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Expressed in late sporogonial stages.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments (By similarity).|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1).|||Vacuole membrane http://togogenome.org/gene/284813:ECU05_1310 ^@ http://purl.uniprot.org/uniprot/Q8SRU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Component of the cytoplasmic LSM1-LSM7 complex which is involved in mRNA degradation.|||Component of the heptameric LSM1-LSM7 complex that forms a seven-membered ring structure with a donut shape.|||Cytoplasm|||P-body http://togogenome.org/gene/284813:ECU05_0250 ^@ http://purl.uniprot.org/uniprot/Q8SS05 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S).|||Cytoplasm http://togogenome.org/gene/284813:ECU01_0960 ^@ http://purl.uniprot.org/uniprot/Q8SSK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/284813:ECU09_1240 ^@ http://purl.uniprot.org/uniprot/Q8STQ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP40 family.|||Cytoplasm http://togogenome.org/gene/284813:ECU03_0950 ^@ http://purl.uniprot.org/uniprot/Q8SS93 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/284813:ECU01_0190 ^@ http://purl.uniprot.org/uniprot/O62585 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Cytoplasm|||Homotetramer.|||Interconversion of serine and glycine. http://togogenome.org/gene/284813:ECU11_1050 ^@ http://purl.uniprot.org/uniprot/Q8SQV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/284813:ECU11_1540 ^@ http://purl.uniprot.org/uniprot/Q8SU17 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/284813:ECU06_0840 ^@ http://purl.uniprot.org/uniprot/Q8SRQ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SSU72 phosphatase family.|||Component of the cleavage and polyadenylation factor (CPF) complex, which plays a key role in polyadenylation-dependent pre-mRNA 3'-end formation and cooperates with cleavage factors including the CFIA complex and NAB4/CFIB. SSU72 is required for 3'-end formation of snoRNAs.|||Component of the cleavage and polyadenylation factor (CPF) complex.|||Nucleus|||Processively dephosphorylates Ser-5 of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). http://togogenome.org/gene/284813:ECU10_1310i ^@ http://purl.uniprot.org/uniprot/Q8SR17 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/284813:ECU08_0060 ^@ http://purl.uniprot.org/uniprot/Q8ST53 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_1520 ^@ http://purl.uniprot.org/uniprot/Q8SR97 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments. This subunit is a non-integral membrane component of the membrane pore domain and is required for proper assembly of the V0 sector. Might be involved in the regulated assembly of V1 subunits onto the membrane sector or alternatively may prevent the passage of protons through V0 pores.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/284813:ECU04_0100 ^@ http://purl.uniprot.org/uniprot/Q8SVY6 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_1440 ^@ http://purl.uniprot.org/uniprot/Q8SQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/284813:ECU11_0810 ^@ http://purl.uniprot.org/uniprot/Q8SU51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/284813:ECU04_0950 ^@ http://purl.uniprot.org/uniprot/Q8SS37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU05_0920 ^@ http://purl.uniprot.org/uniprot/Q8SRW6 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages.|||Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/284813:ECU10_0630 ^@ http://purl.uniprot.org/uniprot/Q8SR53 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU11_1230 ^@ http://purl.uniprot.org/uniprot/Q8SU30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/284813:ECU06_1060 ^@ http://purl.uniprot.org/uniprot/Q8SV98 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the CWC24 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/284813:ECU02_1360 ^@ http://purl.uniprot.org/uniprot/Q8SSD7 ^@ Developmental Stage|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0980 ^@ http://purl.uniprot.org/uniprot/Q8SW31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.|||Cell membrane|||Cytoplasm|||Serine/threonine protein kinase involved in regulation of exocytosis. http://togogenome.org/gene/284813:ECU09_2030 ^@ http://purl.uniprot.org/uniprot/P0CS99 ^@ Developmental Stage|||Similarity ^@ Belongs to the UPF0328 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_0460 ^@ http://purl.uniprot.org/uniprot/Q8SRL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/284813:ECU10_1750 ^@ http://purl.uniprot.org/uniprot/Q8SU99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||microtubule organizing center http://togogenome.org/gene/284813:ECU04_0750 ^@ http://purl.uniprot.org/uniprot/Q8SS48 ^@ Developmental Stage|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also probably able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Expressed in late sporogonial stages.|||Homodimer. The tRNA molecule probably binds across the dimer (By similarity). http://togogenome.org/gene/284813:ECU10_1360 ^@ http://purl.uniprot.org/uniprot/Q8SUC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/284813:ECU01_0480 ^@ http://purl.uniprot.org/uniprot/Q8SWN7 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/284813:ECU11_1740 ^@ http://purl.uniprot.org/uniprot/Q8SU06 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/284813:ECU11_1470 ^@ http://purl.uniprot.org/uniprot/Q8SQT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_0600 ^@ http://purl.uniprot.org/uniprot/Q8SR55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the replication protein A (RPA/RP-A), a single-stranded DNA-binding heterotrimeric complex, may play an essential role in DNA replication, recombination and repair. Binds and stabilizes single-stranded DNA intermediates, preventing complementary DNA reannealing and recruiting different proteins involved in DNA metabolism.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||Nucleus http://togogenome.org/gene/284813:ECU07_0930 ^@ http://purl.uniprot.org/uniprot/Q8SUZ9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/284813:ECU01_0440 ^@ http://purl.uniprot.org/uniprot/Q8SWP0 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_1740 ^@ http://purl.uniprot.org/uniprot/Q8SUU7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_0760 ^@ http://purl.uniprot.org/uniprot/Q8SR44 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU03_0650 ^@ http://purl.uniprot.org/uniprot/Q8SSA6 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_1540 ^@ http://purl.uniprot.org/uniprot/Q8ST97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU08_0470 ^@ http://purl.uniprot.org/uniprot/Q8SRE1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclophilin-type PPIase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||PPIases accelerate the folding of proteins. They catalyze the cis-trans isomerization of proline imidic peptide bonds in oligopeptides (By similarity). http://togogenome.org/gene/284813:ECU07_0060 ^@ http://purl.uniprot.org/uniprot/Q8SV55 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0720 ^@ http://purl.uniprot.org/uniprot/Q8SR46 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284813:ECU04_1180 ^@ http://purl.uniprot.org/uniprot/Q8SS24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Nucleus|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/284813:ECU03_0930 ^@ http://purl.uniprot.org/uniprot/Q8SS94 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/284813:ECU11_1180 ^@ http://purl.uniprot.org/uniprot/Q8SQV3 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/284813:ECU06_1100i ^@ http://purl.uniprot.org/uniprot/Q8SRP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with TFIID-IIA (DA complex) to form TFIID-IIA-IIB (DAB-complex) which is then recognized by polymerase II.|||Belongs to the TFIIB family.|||General factor that plays a major role in the activation of eukaryotic genes transcribed by RNA polymerase II.|||Nucleus http://togogenome.org/gene/284813:ECU06_1110 ^@ http://purl.uniprot.org/uniprot/Q8SRP2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS13 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Located at the top of the head of the 40S subunit, it contacts several helices of the 18S rRNA. http://togogenome.org/gene/284813:ECU04_0460 ^@ http://purl.uniprot.org/uniprot/Q8SS59 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Specifically dimethylates two adjacent adenosines in the loop of a conserved hairpin near the 3'-end of 18S rRNA in the 40S particle. http://togogenome.org/gene/284813:ECU01_0240 ^@ http://purl.uniprot.org/uniprot/Q8SSM8 ^@ Developmental Stage|||Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_0900 ^@ http://purl.uniprot.org/uniprot/Q8SRW8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/284813:ECU11_0540 ^@ http://purl.uniprot.org/uniprot/O96772 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||May act as a chaperone.|||Nucleus http://togogenome.org/gene/284813:ECU02_1540 ^@ http://purl.uniprot.org/uniprot/Q8SW86 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_0560 ^@ http://purl.uniprot.org/uniprot/Q8SR58 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/284813:ECU11_0510 ^@ http://purl.uniprot.org/uniprot/Q8SU65 ^@ Caution|||Developmental Stage ^@ Although it contains a polysaccharide deacetylase domain, the protein does not display any chitin deacetylase activity.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_1510 ^@ http://purl.uniprot.org/uniprot/Q8ST94 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU09_0140 ^@ http://purl.uniprot.org/uniprot/Q8SQQ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex composed of at least BUD32, CGI121, GON7, KAE1 and PCC1; the whole complex dimerizes.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. KAE1 likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity. The EKC/KEOPS complex also promotes both telomere uncapping and telomere elongation. The complex is required for efficient recruitment of transcriptional coactivators.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU02_0240 ^@ http://purl.uniprot.org/uniprot/Q8SSI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/284813:ECU07_1260 ^@ http://purl.uniprot.org/uniprot/Q8SRI4 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/284813:ECU01_0310 ^@ http://purl.uniprot.org/uniprot/Q8SSM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL2 family.|||Cytoplasm http://togogenome.org/gene/284813:ECU04_0330 ^@ http://purl.uniprot.org/uniprot/Q8SS64 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/284813:ECU03_0200 ^@ http://purl.uniprot.org/uniprot/Q8SW70 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family.|||Binds 2 divalent metal cations per subunit.|||Nucleus|||Putative deoxyribonuclease. http://togogenome.org/gene/284813:ECU07_0130 ^@ http://purl.uniprot.org/uniprot/Q8SRM1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ASF1 family.|||Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly.|||Interacts with histone H3 and histone H4.|||Nucleus http://togogenome.org/gene/284813:ECU04_0510 ^@ http://purl.uniprot.org/uniprot/Q8SVW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KRR1 family.|||nucleolus http://togogenome.org/gene/284813:ECU08_1910 ^@ http://purl.uniprot.org/uniprot/Q8SR87 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/284813:ECU05_0290 ^@ http://purl.uniprot.org/uniprot/Q8SS01 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU10_1350 ^@ http://purl.uniprot.org/uniprot/Q8SUC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS11 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU03_0420 ^@ http://purl.uniprot.org/uniprot/Q8SW60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/284813:ECU04_1070 ^@ http://purl.uniprot.org/uniprot/Q8SS31 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/284813:ECU05_0400 ^@ http://purl.uniprot.org/uniprot/Q8SRZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||Nucleus http://togogenome.org/gene/284813:ECU04_1670 ^@ http://purl.uniprot.org/uniprot/Q8SVP2 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0670 ^@ http://purl.uniprot.org/uniprot/Q8SRD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly (By similarity).|||spindle pole body http://togogenome.org/gene/284813:ECU10_0440 ^@ http://purl.uniprot.org/uniprot/Q8SR63 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent rRNA helicase required for pre-ribosomal RNA processing. Involved in the maturation of the 35S-pre-rRNA and to its cleavage to mature 18S rRNA.|||Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily.|||Interacts with the SSU processome.|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284813:ECU06_1610 ^@ http://purl.uniprot.org/uniprot/Q8SV64 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU11_0240 ^@ http://purl.uniprot.org/uniprot/Q8SU86 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/284813:ECU02_1390 ^@ http://purl.uniprot.org/uniprot/Q8SW97 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/284813:ECU04_1380 ^@ http://purl.uniprot.org/uniprot/Q8SS16 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/284813:ECU06_0720 ^@ http://purl.uniprot.org/uniprot/Q8SVB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. Acts as a regulatory subunit for PP2A-like phosphatases modulating their activity or substrate specificity, probably by inducing a conformational change in the catalytic subunit, a direct target of the PPIase. Can reactivate inactive phosphatase PP2A-phosphatase methylesterase complexes (PP2Ai) in presence of ATP and Mg(2+) by dissociating the inactive form from the complex (By similarity). http://togogenome.org/gene/284813:ECU05_0110 ^@ http://purl.uniprot.org/uniprot/Q8SVN5 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0080 ^@ http://purl.uniprot.org/uniprot/Q8SW79 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_1410 ^@ http://purl.uniprot.org/uniprot/Q8SS79 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/284813:ECU05_1030 ^@ http://purl.uniprot.org/uniprot/Q8SRV9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/284813:ECU02_0150 ^@ http://purl.uniprot.org/uniprot/Q8SWG8 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Spore wall http://togogenome.org/gene/284813:ECU09_1650 ^@ http://purl.uniprot.org/uniprot/Q8STM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/284813:ECU07_0790 ^@ http://purl.uniprot.org/uniprot/Q8SV08 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/284813:ECU04_1290 ^@ http://purl.uniprot.org/uniprot/Q8SS19 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/284813:ECU10_0670 ^@ http://purl.uniprot.org/uniprot/Q8SUF5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/284813:ECU10_1600 ^@ http://purl.uniprot.org/uniprot/Q8SUA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/284813:ECU02_0090 ^@ http://purl.uniprot.org/uniprot/Q8SWH3 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU04_1000 ^@ http://purl.uniprot.org/uniprot/Q8SS35 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Cellular myosin that appears to play a role in cytokinesis, cell shape, and specialized functions such as secretion and capping.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU04_1560 ^@ http://purl.uniprot.org/uniprot/Q8SS11 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. Ran family.|||Expressed in late sporogonial stages.|||Found in a nuclear export complex with RanGTP, exportin and pre-miRNA (By similarity).|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU08_0260 ^@ http://purl.uniprot.org/uniprot/Q8SRF2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284813:ECU09_1870 ^@ http://purl.uniprot.org/uniprot/Q8SQJ8 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPP synthase family.|||Cis-prenyl transferase that adds multiple copies of isopentenyl pyrophosphate (IPP) to farnesyl pyrophosphate (FPP) to produce dehydrodolichyl diphosphate (Dedol-PP).|||Endoplasmic reticulum membrane|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU09_2010 ^@ http://purl.uniprot.org/uniprot/Q8STK1 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0820 ^@ http://purl.uniprot.org/uniprot/Q8SR42 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Component of box C/D small nucleolar ribonucleoprotein (snoRNP) particles.|||S-adenosyl-L-methionine-dependent methyltransferase that has the ability to methylate both RNAs and proteins. Involved in pre-rRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in pre-ribosomal RNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. Also acts as a protein methyltransferase by mediating methylation of 'Gln-105' of histone H2A (H2AQ105me), a modification that impairs binding of the FACT complex and is specifically present at 35S ribosomal DNA locus (By similarity).|||nucleolus http://togogenome.org/gene/284813:ECU03_0230 ^@ http://purl.uniprot.org/uniprot/Q8SSC8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/284813:ECU05_1460 ^@ http://purl.uniprot.org/uniprot/Q8SVG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU04_0700 ^@ http://purl.uniprot.org/uniprot/Q8SS50 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284813:ECU01_1230 ^@ http://purl.uniprot.org/uniprot/Q8SSJ5 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AAA ATPase family.|||Component of the ribosome quality control complex (RQC), composed of the E3 ubiquitin ligase LTN1, RQC1 and RQC2, as well as CDC48 and its ubiquitin-binding cofactors. RQC forms a stable complex with 60S ribosomal subunits.|||Endoplasmic reticulum|||Expressed in late sporogonial stages.|||Involved in spindle disassembly, degradation of ubiquitinated proteins and protein export from the endoplasmic reticulum to the cytoplasm. Acts as a chaperone that collects ubiquitinated substrates. Has a role in the endoplasmic reticulum-associated degradation (ERAD) pathway. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. CDC48 may provide the mechanical force that dislodges the polyubiquitinated nascent peptides from the exit channel. http://togogenome.org/gene/284813:ECU05_1400 ^@ http://purl.uniprot.org/uniprot/Q8SRU3 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU09_0440 ^@ http://purl.uniprot.org/uniprot/Q8SQP4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Glutarylation at Lys-94 (H4K91glu) destabilizes nucleosomes by promoting dissociation of the H2A-H2B dimers from nucleosomes.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/284813:ECU11_1750 ^@ http://purl.uniprot.org/uniprot/Q8SQS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat TAF5 family.|||Component of the TFIID and SAGA complexes. TFIID is composed of TATA binding protein (TBP) and a number of TBP-associated factors (TAFs) (By similarity).|||Nucleus|||TAFs are components of the transcription factor IID (TFIID) complex that are essential for mediating regulation of RNA polymerase transcription. Regulates the genes involved in ubiquitin-dependent proteolysis during the progression of M-phase of mitosis (By similarity). http://togogenome.org/gene/284813:ECU09_0230 ^@ http://purl.uniprot.org/uniprot/Q8STX3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284813:ECU03_1370 ^@ http://purl.uniprot.org/uniprot/Q8SS80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU05_0300 ^@ http://purl.uniprot.org/uniprot/Q8SS00 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/284813:ECU07_1780 ^@ http://purl.uniprot.org/uniprot/Q8SUU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Nucleus|||The GINS complex plays an essential role in the initiation of DNA replication. http://togogenome.org/gene/284813:ECU11_1330 ^@ http://purl.uniprot.org/uniprot/Q8SQU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU05_1280 ^@ http://purl.uniprot.org/uniprot/Q8SRV0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Forms a complex with RAD50.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU11_1270 ^@ http://purl.uniprot.org/uniprot/Q8SU27 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||Expressed in late sporogonial stages.|||Nucleus http://togogenome.org/gene/284813:ECU02_0340 ^@ http://purl.uniprot.org/uniprot/Q8SSI0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU02_0520 ^@ http://purl.uniprot.org/uniprot/Q8SSH3 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU08_1160i ^@ http://purl.uniprot.org/uniprot/Q8SRA7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/284813:ECU08_1100 ^@ http://purl.uniprot.org/uniprot/Q8SRB1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284813:ECU10_0130 ^@ http://purl.uniprot.org/uniprot/Q8SQI9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the AAA ATPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU09_1260 ^@ http://purl.uniprot.org/uniprot/Q8STQ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/284813:ECU03_0040 ^@ http://purl.uniprot.org/uniprot/Q8SW83 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU01_1210 ^@ http://purl.uniprot.org/uniprot/Q8SSJ7 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/284813:ECU11_0130 ^@ http://purl.uniprot.org/uniprot/Q8STJ2 ^@ Similarity ^@ To E.cuniculi ECU03_0120. http://togogenome.org/gene/284813:ECU04_1090 ^@ http://purl.uniprot.org/uniprot/Q8SS30 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/284813:ECU11_0560 ^@ http://purl.uniprot.org/uniprot/Q8SU63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/284813:ECU08_0300 ^@ http://purl.uniprot.org/uniprot/Q8SUT3 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/284813:ECU09_0130 ^@ http://purl.uniprot.org/uniprot/Q8SQQ4 ^@ Similarity ^@ Belongs to the SecY/SEC61-alpha family. http://togogenome.org/gene/284813:ECU02_0980 ^@ http://purl.uniprot.org/uniprot/Q8SWC1 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/284813:ECU01_0070 ^@ http://purl.uniprot.org/uniprot/Q8ST97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU06_0870 ^@ http://purl.uniprot.org/uniprot/Q8SRQ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU08_0680 ^@ http://purl.uniprot.org/uniprot/Q8SRD1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Expressed in late sporogonial stages.|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins (By similarity). The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex (By similarity). http://togogenome.org/gene/284813:ECU05_1690 ^@ http://purl.uniprot.org/uniprot/Q8ST65 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_1560 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0880 ^@ http://purl.uniprot.org/uniprot/Q8SRB8 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Expressed in late sporogonial stages.|||Mitochondrion|||Nucleus http://togogenome.org/gene/284813:ECU08_0970 ^@ http://purl.uniprot.org/uniprot/Q8SRB4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_0990 ^@ http://purl.uniprot.org/uniprot/O62581 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/284813:ECU11_0140 ^@ http://purl.uniprot.org/uniprot/Q8SQI1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA glycosylase MPG family.|||Expressed in late sporogonial stages.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.|||Nucleus http://togogenome.org/gene/284813:ECU03_0580 ^@ http://purl.uniprot.org/uniprot/Q8SSA9 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/284813:ECU04_0620 ^@ http://purl.uniprot.org/uniprot/Q8SVV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/284813:ECU06_1480 ^@ http://purl.uniprot.org/uniprot/Q8SRM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU11_1510 ^@ http://purl.uniprot.org/uniprot/Q8SQT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU01_1060 ^@ http://purl.uniprot.org/uniprot/Q8SSK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent 3'-5' DNA helicase, component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. The ATPase activity of XPB/SSL2, but not its helicase activity, is required for DNA opening. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. The ATP-dependent helicase activity of XPB/SSL2 is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Belongs to the helicase family. RAD25/XPB subfamily.|||Component of the 7-subunit TFIIH core complex composed of XPB/SSL2, XPD/RAD3, SSL1, TFB1, TFB2, TFB4 and TFB5, which is active in NER. The core complex associates with the 3-subunit CTD-kinase module TFIIK composed of CCL1, KIN28 and TFB3 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription.|||Nucleus http://togogenome.org/gene/284813:ECU11_2090 ^@ http://purl.uniprot.org/uniprot/Q8STZ1 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU11_0900 ^@ http://purl.uniprot.org/uniprot/Q8SU49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/284813:ECU04_0450 ^@ http://purl.uniprot.org/uniprot/Q8SS60 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S). Interacts with RPS21.|||Cytoplasm|||Expressed in late sporogonial stages.|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. http://togogenome.org/gene/284813:ECU11_1880 ^@ http://purl.uniprot.org/uniprot/Q8SQR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/284813:ECU05_0070 ^@ http://purl.uniprot.org/uniprot/Q8SVN8 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NTE family.|||Endoplasmic reticulum membrane|||Inhibited by organophosphorus esters.|||Intracellular phospholipase B that catalyzes the double deacylation of phosphatidylcholine (PC) to glycerophosphocholine (GroPCho). Plays an important role in membrane lipid homeostasis. Responsible for the rapid PC turnover in response to inositol, elevated temperatures, or when choline is present in the growth medium (By similarity). http://togogenome.org/gene/284813:ECU04_0140 ^@ http://purl.uniprot.org/uniprot/Q8SS72 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_0590 ^@ http://purl.uniprot.org/uniprot/Q8SV20 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/284813:ECU10_1180 ^@ http://purl.uniprot.org/uniprot/Q8SR25 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/284813:ECU02_0070 ^@ http://purl.uniprot.org/uniprot/Q8SWH5 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_1330 ^@ http://purl.uniprot.org/uniprot/Q8SR16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/284813:ECU02_0610 ^@ http://purl.uniprot.org/uniprot/Q8SSG9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Component of the large ribosomal subunit.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus http://togogenome.org/gene/284813:ECU08_1830 ^@ http://purl.uniprot.org/uniprot/Q8SUJ4 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/284813:ECU05_0670 ^@ http://purl.uniprot.org/uniprot/Q8SRY0 ^@ PTM|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family.|||Phosphorylated. http://togogenome.org/gene/284813:ECU10_0240 ^@ http://purl.uniprot.org/uniprot/Q8SR76 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU02_1450 ^@ http://purl.uniprot.org/uniprot/Q8SW92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Component of the TFIIH holo complex.|||Nucleus|||Protein kinase component of transcription factor IIH (TFIIH) which phosphorylates the C-terminal domain of RNA polymerase II during transition from transcription to elongation after preinitiation complex (PIC) formation, thereby positively regulating transcription. Essential for both basal and activated transcription, and is involved in nucleotide excision repair (NER) of damaged DNA (By similarity). http://togogenome.org/gene/284813:ECU08_1110 ^@ http://purl.uniprot.org/uniprot/Q8SRB0 ^@ Developmental Stage|||Similarity ^@ Belongs to the WD repeat G protein beta family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_0890 ^@ http://purl.uniprot.org/uniprot/Q8SRB7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU08_0440 ^@ http://purl.uniprot.org/uniprot/Q8SUS7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU09_1805 ^@ http://purl.uniprot.org/uniprot/Q8SQK1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Component of LSm protein complexes, which are involved in RNA processing and may function in a chaperone-like manner. LSM2 binds specifically to the 3'-terminal U-tract of U6 snRNA. Required for processing of pre-tRNAs, pre-rRNAs and U3 snoRNA (By similarity).|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/284813:ECU06_1280 ^@ http://purl.uniprot.org/uniprot/Q8SV85 ^@ Similarity ^@ Belongs to the SNAP family. http://togogenome.org/gene/284813:ECU06_1650 ^@ http://purl.uniprot.org/uniprot/Q8SV60 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_0770 ^@ http://purl.uniprot.org/uniprot/Q8SSF9 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS17 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_1130 ^@ http://purl.uniprot.org/uniprot/Q8SRI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU06_1570 ^@ http://purl.uniprot.org/uniprot/Q8SRM5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284813:ECU04_0125i ^@ http://purl.uniprot.org/uniprot/Q8SS73 ^@ Cofactor|||Similarity ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU09_1840 ^@ http://purl.uniprot.org/uniprot/Q8SQK0 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the AAA ATPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU07_0770 ^@ http://purl.uniprot.org/uniprot/Q8SRJ9 ^@ Subcellular Location Annotation ^@ Nucleus membrane|||perinuclear region http://togogenome.org/gene/284813:ECU04_0930 ^@ http://purl.uniprot.org/uniprot/Q8SS38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU10_1790 ^@ http://purl.uniprot.org/uniprot/Q8SQZ6 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the ATP-dependent ligation of glycine to the 3'-end of its cognate tRNA, via the formation of an aminoacyl-adenylate intermediate (Gly-AMP). Also produces diadenosine tetraphosphate (Ap4A), a universal pleiotropic signaling molecule needed for cell regulation pathways, by direct condensation of 2 ATPs. Thereby, may play a special role in Ap4A homeostasis.|||Expressed in late sporogonial stages.|||Homodimer. http://togogenome.org/gene/284813:ECU06_1420i ^@ http://purl.uniprot.org/uniprot/Q8SRN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU09_0850 ^@ http://purl.uniprot.org/uniprot/Q8STS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/284813:ECU06_0350 ^@ http://purl.uniprot.org/uniprot/Q8SRS3 ^@ Function ^@ Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/284813:ECU06_0990 ^@ http://purl.uniprot.org/uniprot/Q8SRP9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU02_0900 ^@ http://purl.uniprot.org/uniprot/Q8SSF3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/284813:ECU04_0910 ^@ http://purl.uniprot.org/uniprot/Q8SS39 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/284813:ECU07_0600 ^@ http://purl.uniprot.org/uniprot/Q8SV19 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adrenodoxin/putidaredoxin family.|||Binds 1 [2Fe-2S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions.|||Mitosome http://togogenome.org/gene/284813:ECU11_1670 ^@ http://purl.uniprot.org/uniprot/Q8SQS5 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU03_1180 ^@ http://purl.uniprot.org/uniprot/Q8SS86 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Expression is low in meronts, but becomes induced in sporonts and spores.|||May be involved in the degradation of proteins for nutrient acquisition or possess a regulatory function by proteolytic activation of proproteins.|||Membrane http://togogenome.org/gene/284813:ECU08_1440 ^@ http://purl.uniprot.org/uniprot/Q8SUM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/284813:ECU07_1730 ^@ http://purl.uniprot.org/uniprot/Q8SUU8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU02_0490 ^@ http://purl.uniprot.org/uniprot/Q8SWE5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex CFD1-NBP35. Electrons are transferred to DRE2 from NADPH via the FAD- and FMN-containing protein TAH18. TAH18-DRE2 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit RNR2.|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer. Interacts with TAH18. Interacts with MIA40.|||The C-terminal domain binds 1 Fe-S cluster but is otherwise mostly in an intrinsically disordered conformation.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/284813:ECU06_1450 ^@ http://purl.uniprot.org/uniprot/Q8SRN1 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/284813:ECU08_0080 ^@ http://purl.uniprot.org/uniprot/O62583 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). http://togogenome.org/gene/284813:ECU03_1010 ^@ http://purl.uniprot.org/uniprot/Q8SW28 ^@ Developmental Stage|||Similarity ^@ Belongs to the 14-3-3 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU02_0750i ^@ http://purl.uniprot.org/uniprot/Q8SSG1 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU06_1500 ^@ http://purl.uniprot.org/uniprot/Q8SV70 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU08_0650 ^@ http://purl.uniprot.org/uniprot/Q8SRD3 ^@ Similarity ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU04_1210 ^@ http://purl.uniprot.org/uniprot/Q8SS23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/284813:ECU06_0200 ^@ http://purl.uniprot.org/uniprot/Q8SRT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU01_1120 ^@ http://purl.uniprot.org/uniprot/Q8SWJ2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/284813:ECU05_0870 ^@ http://purl.uniprot.org/uniprot/Q8SRX0 ^@ Similarity ^@ Belongs to the HAM1 NTPase family. http://togogenome.org/gene/284813:ECU07_1050 ^@ http://purl.uniprot.org/uniprot/Q8SUZ0 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/284813:ECU01_0250 ^@ http://purl.uniprot.org/uniprot/Q8SWQ4 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU11_0010 ^@ http://purl.uniprot.org/uniprot/Q8STE8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU02_0800 ^@ http://purl.uniprot.org/uniprot/Q8SSF7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/284813:ECU09_0960 ^@ http://purl.uniprot.org/uniprot/Q8STR9 ^@ Similarity ^@ Belongs to the SPCS3 family. http://togogenome.org/gene/284813:ECU06_0280 ^@ http://purl.uniprot.org/uniprot/Q8SRS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU07_1420 ^@ http://purl.uniprot.org/uniprot/Q8SRH6 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Non-catalytic component of the proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity).|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU04_0640 ^@ http://purl.uniprot.org/uniprot/Q8SS53 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/284813:ECU11_1920 ^@ http://purl.uniprot.org/uniprot/Q8SQR4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/284813:ECU01_0910 ^@ http://purl.uniprot.org/uniprot/Q8SWK6 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU03_0910 ^@ http://purl.uniprot.org/uniprot/Q8SS96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily.|||Involved in DNA repair. May regulate the activity of protein(s) involved in double strand break repair caused by gamma rays (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU08_1660 ^@ http://purl.uniprot.org/uniprot/Q8SR92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus|||The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene.|||centromere http://togogenome.org/gene/284813:ECU04_0790 ^@ http://purl.uniprot.org/uniprot/Q8SS46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU01_1290 ^@ http://purl.uniprot.org/uniprot/Q8SSJ2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/284813:ECU03_0440 ^@ http://purl.uniprot.org/uniprot/Q8SSB7 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284813:ECU03_0120 ^@ http://purl.uniprot.org/uniprot/Q8SW75 ^@ Similarity ^@ To E.cuniculi ECU05_1600/ECU11_0130. http://togogenome.org/gene/284813:ECU10_1460 ^@ http://purl.uniprot.org/uniprot/Q8SR10 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/284813:ECU08_0330 ^@ http://purl.uniprot.org/uniprot/Q8SUT1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MMR1/HSR1 GTP-binding protein family.|||Expressed in late sporogonial stages.|||Required for normal processing of ribosomal pre-rRNA. Required for cell proliferation. Binds GTP (By similarity).|||nucleolus http://togogenome.org/gene/284813:ECU08_1930 ^@ http://purl.uniprot.org/uniprot/Q8SQH8 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Expressed in late sporogonial stages.|||GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/284813:ECU03_0030 ^@ http://purl.uniprot.org/uniprot/Q8STE8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU04_1130 ^@ http://purl.uniprot.org/uniprot/Q8SS28 ^@ Similarity ^@ Belongs to the glycosyltransferase 15 family. http://togogenome.org/gene/284813:ECU01_0955 ^@ http://purl.uniprot.org/uniprot/Q8SWK3 ^@ Similarity ^@ Belongs to the MBF1 family. http://togogenome.org/gene/284813:ECU11_0980 ^@ http://purl.uniprot.org/uniprot/Q8SQW1 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/284813:ECU04_1360 ^@ http://purl.uniprot.org/uniprot/Q8SVR6 ^@ Similarity|||Subunit ^@ Belongs to the CutA family.|||Homotrimer. http://togogenome.org/gene/284813:ECU10_0530 ^@ http://purl.uniprot.org/uniprot/Q8SR60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/284813:ECU04_1400 ^@ http://purl.uniprot.org/uniprot/Q8SS15 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284813:ECU11_0030 ^@ http://purl.uniprot.org/uniprot/Q8SU90 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU11_0020 ^@ http://purl.uniprot.org/uniprot/Q8STJ4 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0870 ^@ http://purl.uniprot.org/uniprot/Q8SR40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU01_1430 ^@ http://purl.uniprot.org/uniprot/O62584 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/284813:ECU02_0760 ^@ http://purl.uniprot.org/uniprot/Q8SSG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (By similarity). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids.|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11 and three accessory subunits SPC1, SPC2 and SPC3 (By similarity). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates. This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). SPC associates with the translocon complex.|||Endoplasmic reticulum membrane http://togogenome.org/gene/284813:ECU03_1170 ^@ http://purl.uniprot.org/uniprot/Q8SW18 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU04_0580 ^@ http://purl.uniprot.org/uniprot/Q8SS56 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284813:ECU07_0070 ^@ http://purl.uniprot.org/uniprot/Q8SV54 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU09_1820 ^@ http://purl.uniprot.org/uniprot/Q8STL3 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_0470 ^@ http://purl.uniprot.org/uniprot/Q8SVL8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/284813:ECU07_0700 ^@ http://purl.uniprot.org/uniprot/Q8SRK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284813:ECU05_1230 ^@ http://purl.uniprot.org/uniprot/Q8SRV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/284813:ECU02_0230 ^@ http://purl.uniprot.org/uniprot/Q8SSI5 ^@ Similarity ^@ Belongs to the IPP isomerase type 1 family. http://togogenome.org/gene/284813:ECU01_0650 ^@ http://purl.uniprot.org/uniprot/Q8SSL7 ^@ Cofactor|||Developmental Stage|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, which is a biosynthetic precursor of chitin and also supplies the amino sugars for N-linked oligosaccharides of glycoproteins.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_1250 ^@ http://purl.uniprot.org/uniprot/Q95ZE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/284813:ECU10_1575 ^@ http://purl.uniprot.org/uniprot/Q8SR05 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS30 family. http://togogenome.org/gene/284813:ECU05_0780 ^@ http://purl.uniprot.org/uniprot/Q8SRX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284813:ECU04_0570 ^@ http://purl.uniprot.org/uniprot/Q8SVV6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU01_1450 ^@ http://purl.uniprot.org/uniprot/O62583 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). http://togogenome.org/gene/284813:ECU05_1520 ^@ http://purl.uniprot.org/uniprot/Q8SRT9 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/284813:ECU09_1005 ^@ http://purl.uniprot.org/uniprot/Q8STR6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH3 family.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm|||Nucleus|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising KTI11/DPH3 and a NADH-dependent reductase, predominantly CBR1. Acts as an electron donor to reduce the Fe-S cluster in DPH1-DPH2 keeping the [4Fe-4S] clusters in the active and reduced state. Restores iron to DPH1-DPH2 iron-sulfur clusters which have degraded from [4Fe-4S] to [3Fe-4S] by donating an iron atom to reform [4Fe-4S] clusters, in a manner dependent on the presence of elongation factor 2 and SAM. Associates with the elongator complex and is required for tRNA Wobble base modifications mediated by the elongator complex. The elongator complex is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s 2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine).|||The DPH-type metal-binding (MB) domain can also bind zinc. However, iron is the physiological binding partner as zinc binding impairs the protein electron donor function. http://togogenome.org/gene/284813:ECU10_1440 ^@ http://purl.uniprot.org/uniprot/Q8SUB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/284813:ECU05_1390 ^@ http://purl.uniprot.org/uniprot/Q8SVH0 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU04_1340 ^@ http://purl.uniprot.org/uniprot/Q8SVR8 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/284813:ECU03_1350 ^@ http://purl.uniprot.org/uniprot/Q8SS81 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/284813:ECU11_2000 ^@ http://purl.uniprot.org/uniprot/Q8SQR0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU06_0460 ^@ http://purl.uniprot.org/uniprot/Q8SRR9 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/284813:ECU09_1500 ^@ http://purl.uniprot.org/uniprot/Q8STN5 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/284813:ECU11_0480 ^@ http://purl.uniprot.org/uniprot/Q8SQI7 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/284813:ECU11_1780 ^@ http://purl.uniprot.org/uniprot/Q8SQS1 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UDPGP type 1 family.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_0570 ^@ http://purl.uniprot.org/uniprot/Q8SUR8 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/284813:ECU07_0450 ^@ http://purl.uniprot.org/uniprot/Q8SV30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/284813:ECU10_0420 ^@ http://purl.uniprot.org/uniprot/Q8SUG7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.|||Belongs to the ADP/ATP translocase tlc family.|||Cell membrane http://togogenome.org/gene/284813:ECU07_1460 ^@ http://purl.uniprot.org/uniprot/Q8SRH5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/284813:ECU11_0230 ^@ http://purl.uniprot.org/uniprot/Q8SQZ1 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/284813:ECU09_0090 ^@ http://purl.uniprot.org/uniprot/Q8SQQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/284813:ECU03_0530 ^@ http://purl.uniprot.org/uniprot/Q8SW56 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/284813:ECU03_0590 ^@ http://purl.uniprot.org/uniprot/Q8SW52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/284813:ECU05_1600 ^@ http://purl.uniprot.org/uniprot/Q8STJ2 ^@ Similarity ^@ To E.cuniculi ECU03_0120. http://togogenome.org/gene/284813:ECU04_1015 ^@ http://purl.uniprot.org/uniprot/Q8SS34 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/284813:ECU07_0800 ^@ http://purl.uniprot.org/uniprot/Q8SRJ8 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/284813:ECU11_1080 ^@ http://purl.uniprot.org/uniprot/Q8SQV7 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/284813:ECU10_0400 ^@ http://purl.uniprot.org/uniprot/Q8SR65 ^@ Developmental Stage|||Similarity ^@ Belongs to the universal ribosomal protein uS12 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0305 ^@ http://purl.uniprot.org/uniprot/Q8SSC3 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/284813:ECU04_0260 ^@ http://purl.uniprot.org/uniprot/Q8SVX7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284813:ECU01_1170 ^@ http://purl.uniprot.org/uniprot/Q8SWI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/284813:ECU10_1850 ^@ http://purl.uniprot.org/uniprot/Q8SU92 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_0490 ^@ http://purl.uniprot.org/uniprot/Q8SSB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/284813:ECU07_0890 ^@ http://purl.uniprot.org/uniprot/Q8SV03 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Monomer.|||Nucleus|||Processively dephosphorylates 'Ser-2' and 'Ser-5' of the heptad repeats YSPTSPS in the C-terminal domain of the largest RNA polymerase II subunit (RPB1). This promotes the activity of RNA polymerase II. http://togogenome.org/gene/284813:ECU05_1680 ^@ http://purl.uniprot.org/uniprot/Q8STA9 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_1590 ^@ http://purl.uniprot.org/uniprot/Q8SR03 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/284813:ECU09_1200 ^@ http://purl.uniprot.org/uniprot/Q8SQM5 ^@ Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase which is a subunit of the eIF4F complex involved in cap recognition and is required for mRNA binding to ribosome. In the current model of translation initiation, eIF4A unwinds RNA secondary structures in the 5'-UTR of mRNAs which is necessary to allow efficient binding of the small ribosomal subunit, and subsequent scanning for the initiator codon (By similarity).|||Belongs to the DEAD box helicase family. eIF4A subfamily.|||Component of the eIF4F complex, which composition varies with external and internal environmental conditions. It is composed of at least eIF4A, eIF4E and eIF4G (By similarity).|||Cytoplasm|||Expressed in late sporogonial stages.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284813:ECU10_1420 ^@ http://purl.uniprot.org/uniprot/Q8SR13 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the AAA ATPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU04_1060 ^@ http://purl.uniprot.org/uniprot/Q8SS32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/284813:ECU05_0320 ^@ http://purl.uniprot.org/uniprot/Q8SRZ8 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/284813:ECU11_1340 ^@ http://purl.uniprot.org/uniprot/Q8SQU5 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU08_0210 ^@ http://purl.uniprot.org/uniprot/Q8SRF6 ^@ Function|||Similarity ^@ Belongs to the WD repeat SEC31 family.|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. http://togogenome.org/gene/284813:ECU04_0970 ^@ http://purl.uniprot.org/uniprot/Q8SVT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU08_1290 ^@ http://purl.uniprot.org/uniprot/Q8SRA3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/284813:ECU02_1240 ^@ http://purl.uniprot.org/uniprot/Q8SSE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus http://togogenome.org/gene/284813:ECU07_0400 ^@ http://purl.uniprot.org/uniprot/Q8SV33 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Golgi apparatus http://togogenome.org/gene/284813:ECU07_0530 ^@ http://purl.uniprot.org/uniprot/Q8SV25 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU05_1240 ^@ http://purl.uniprot.org/uniprot/Q8SRV2 ^@ Function ^@ Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates. http://togogenome.org/gene/284813:ECU02_0880 ^@ http://purl.uniprot.org/uniprot/Q8SWC9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/284813:ECU08_1960 ^@ http://purl.uniprot.org/uniprot/Q8SR85 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.|||Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis (By similarity). http://togogenome.org/gene/284813:ECU08_1550 ^@ http://purl.uniprot.org/uniprot/Q8SUL4 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU05_0030 ^@ http://purl.uniprot.org/uniprot/P0CS96 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_0860 ^@ http://purl.uniprot.org/uniprot/Q8STS6 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/284813:ECU06_0120 ^@ http://purl.uniprot.org/uniprot/Q8SVF0 ^@ Similarity ^@ Belongs to the transketolase family. http://togogenome.org/gene/284813:ECU03_1240 ^@ http://purl.uniprot.org/uniprot/Q8SW15 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. May also be involved in protein urmylation. http://togogenome.org/gene/284813:ECU08_0340 ^@ http://purl.uniprot.org/uniprot/Q8SRE8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/284813:ECU08_1060 ^@ http://purl.uniprot.org/uniprot/Q8SRB3 ^@ Developmental Stage|||Similarity ^@ Belongs to the universal ribosomal protein uS15 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_0090 ^@ http://purl.uniprot.org/uniprot/Q8SQH8 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||Expressed in late sporogonial stages.|||GTP-binding protein involved in protein trafficking; may modulate vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/284813:ECU08_0830 ^@ http://purl.uniprot.org/uniprot/Q8SRC2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/284813:ECU11_1860 ^@ http://purl.uniprot.org/uniprot/Q8SU01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU10_0340 ^@ http://purl.uniprot.org/uniprot/Q8SR69 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Involved in osmoadaptation. http://togogenome.org/gene/284813:ECU06_1520 ^@ http://purl.uniprot.org/uniprot/Q8SRM8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B-like family. http://togogenome.org/gene/284813:ECU06_1550 ^@ http://purl.uniprot.org/uniprot/Q8SRM6 ^@ Similarity ^@ Belongs to the WD repeat rae1 family. http://togogenome.org/gene/284813:ECU01_0820 ^@ http://purl.uniprot.org/uniprot/Q8SWL3 ^@ Developmental Stage|||Domain|||Function|||Subcellular Location Annotation ^@ Expressed during merogony and a large part of sporogony.|||Heparin-binding motifs (HBMs) are characterized by an XBBXBX or XBBBXXBX sequence, where X is any neutral amino acid and B is a positively charged basic amino acid, and are defined as the consensus sequence necessary for protein-heparin interactions. HBM1 motif is necessary for spore adherence to host cells.|||Spore wall|||Spore wall protein involved in the adhesion to host cells surface glycoaminoglycans (GAGs). Microsporidian spore adherence is an integral part of activation and host cell invasion which requires the extrusion at the spore apex of a very long and coiled structure, the polar tube, through which the sporoplasm is pushed to enter into the potential host cell.|||perispore http://togogenome.org/gene/284813:ECU08_0700 ^@ http://purl.uniprot.org/uniprot/Q8SRC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/284813:ECU04_0650 ^@ http://purl.uniprot.org/uniprot/Q8SVV2 ^@ Similarity ^@ Belongs to the SWI5/SAE3 family. http://togogenome.org/gene/284813:ECU11_0880 ^@ http://purl.uniprot.org/uniprot/Q8SQI7 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/284813:ECU10_0410 ^@ http://purl.uniprot.org/uniprot/Q8SR64 ^@ Similarity ^@ Belongs to the proteasome subunit S5A family. http://togogenome.org/gene/284813:ECU06_0740 ^@ http://purl.uniprot.org/uniprot/Q8SRR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/KNOX homeobox family.|||Nucleus http://togogenome.org/gene/284813:ECU09_1400 ^@ http://purl.uniprot.org/uniprot/Q8STP1 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU09_1290 ^@ http://purl.uniprot.org/uniprot/Q8STP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP11 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/284813:ECU04_1550 ^@ http://purl.uniprot.org/uniprot/Q8SVQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fungal TPase family.|||First step of mRNA capping. Converts the 5'-triphosphate end of a nascent mRNA chain into a diphosphate end.|||Heterodimer. The mRNA-capping enzyme is composed of two separate chains alpha and beta, respectively a mRNA guanylyltransferase and an mRNA 5'-triphosphate monophosphatase.|||Nucleus http://togogenome.org/gene/284813:ECU06_0510 ^@ http://purl.uniprot.org/uniprot/Q8SRR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU01_1390 ^@ http://purl.uniprot.org/uniprot/Q8SSI7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chitin synthase family. Class IV subfamily.|||Cell membrane|||Expression is low in meronts, but becomes induced when meronts start to differentiate into sporonts.|||Polymerizes chitin, a structural polymer of the cell wall and septum, by transferring the sugar moiety of UDP-GlcNAc to the non-reducing end of the growing chitin polymer. http://togogenome.org/gene/284813:ECU05_0580 ^@ http://purl.uniprot.org/uniprot/Q8SRY6 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/284813:ECU02_1480 ^@ http://purl.uniprot.org/uniprot/Q8SW89 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC24 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/284813:ECU11_1320 ^@ http://purl.uniprot.org/uniprot/Q8SU25 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Expressed in late sporogonial stages.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||cis-Golgi network http://togogenome.org/gene/284813:ECU11_1440 ^@ http://purl.uniprot.org/uniprot/Q8MTP3 ^@ Developmental Stage|||Function|||Subcellular Location Annotation|||Subunit ^@ Found in spores. Expression is high during polar tube formation.|||Interacts with PTP1 and PTP2.|||Involved in the sporoblast-to-spore polar tube biogenesis. Plays a role in the control of the polar tube extrusion as part of a specific response to ionic stimuli.|||Spore polar tube http://togogenome.org/gene/284813:ECU03_1380 ^@ http://purl.uniprot.org/uniprot/Q8SW06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm http://togogenome.org/gene/284813:ECU07_0920 ^@ http://purl.uniprot.org/uniprot/Q8SV00 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Secreted http://togogenome.org/gene/284813:ECU06_0940 ^@ http://purl.uniprot.org/uniprot/Q8SVA6 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. Thiolase family.|||Expressed in late sporogonial stages.|||Homodimer.|||Peroxisome http://togogenome.org/gene/284813:ECU02_0780 ^@ http://purl.uniprot.org/uniprot/Q8SSF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIF beta subunit family.|||Nucleus http://togogenome.org/gene/284813:ECU10_0210 ^@ http://purl.uniprot.org/uniprot/Q8SR78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/284813:ECU10_1450 ^@ http://purl.uniprot.org/uniprot/Q8SR11 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU11_0750 ^@ http://purl.uniprot.org/uniprot/Q8SU53 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PNO1 family.|||Component of the small ribosomal subunit, ribosomal RNA processing complex (SSU RRP complex).|||Required for small ribosomal subunit (SSU) synthesis. Has a role in the processing of early nucleolar and late cytoplasmic pre-RNA species.|||nucleolus http://togogenome.org/gene/284813:ECU06_0600 ^@ http://purl.uniprot.org/uniprot/Q8SRR5 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU01_1330 ^@ http://purl.uniprot.org/uniprot/Q8SSI9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TAF9 family.|||Component of the DNA-binding general transcription factor complex TFIID. Component of histone acetyl transferase (HAT) complexes such as SAGA (By similarity).|||Expressed in late sporogonial stages.|||Functions as a component of the DNA-binding general transcription factor complex TFIID. May also function as a component of transcription regulatory histone acetyl transferase (HAT) complexes such as SAGA. Binding of TFIID to a promoter (with or without TATA element) is the initial step in preinitiation complex (PIC) formation. TFIID plays a key role in the regulation of gene expression by RNA polymerase II through different activities such as transcription activator interaction, core promoter recognition and selectivity, TFIIA and TFIIB interaction, chromatin modification, facilitation of DNA opening and initiation of transcription (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU03_0250 ^@ http://purl.uniprot.org/uniprot/Q8SW68 ^@ Similarity ^@ Belongs to the CHS7 family. http://togogenome.org/gene/284813:ECU01_1560 ^@ http://purl.uniprot.org/uniprot/P0CT02|||http://purl.uniprot.org/uniprot/P0CT03 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU05_0950 ^@ http://purl.uniprot.org/uniprot/Q8SRW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU04_0710 ^@ http://purl.uniprot.org/uniprot/Q8SVU9 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/284813:ECU02_0140 ^@ http://purl.uniprot.org/uniprot/Q8SSI6 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RANBP1 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Important for the export of protein containing nuclear export signal (NES) out of the nucleus.|||Nucleus http://togogenome.org/gene/284813:ECU10_1280 ^@ http://purl.uniprot.org/uniprot/Q8SR19 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284813:ECU10_0010 ^@ http://purl.uniprot.org/uniprot/Q8ST30 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_1510 ^@ http://purl.uniprot.org/uniprot/Q8SVZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/284813:ECU05_0760 ^@ http://purl.uniprot.org/uniprot/Q8SVK1 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/284813:ECU11_1950 ^@ http://purl.uniprot.org/uniprot/Q8SQR3 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Component of the septin complex.|||Expressed in late sporogonial stages.|||Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity). http://togogenome.org/gene/284813:ECU08_1570 ^@ http://purl.uniprot.org/uniprot/Q8SR96 ^@ Developmental Stage|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (25S, 5.8S and 5S) (By similarity).|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_0250 ^@ http://purl.uniprot.org/uniprot/Q8SR75 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB2 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template (By similarity).|||Nucleus|||The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits (By similarity). http://togogenome.org/gene/284813:ECU09_0310 ^@ http://purl.uniprot.org/uniprot/Q8SQQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/284813:ECU10_0830 ^@ http://purl.uniprot.org/uniprot/Q8SR41 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/284813:ECU10_1020 ^@ http://purl.uniprot.org/uniprot/Q8SUD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU03_0920 ^@ http://purl.uniprot.org/uniprot/Q8SS95 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/284813:ECU06_0620 ^@ http://purl.uniprot.org/uniprot/Q8SRR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU07_0750 ^@ http://purl.uniprot.org/uniprot/Q8SRK1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat RBAP46/RBAP48/MSI1 family.|||Component of the HAT-B complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||Regulatory subunit of the histone acetylase B (HAT-B) complex. The complex acetylates histone H4 which is required for telomeric silencing (By similarity). http://togogenome.org/gene/284813:ECU11_1810 ^@ http://purl.uniprot.org/uniprot/Q8SQS0 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/284813:ECU09_0970 ^@ http://purl.uniprot.org/uniprot/Q8STR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU08_0270 ^@ http://purl.uniprot.org/uniprot/Q8SUT4 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_1920 ^@ http://purl.uniprot.org/uniprot/Q8SR86 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Cyclin-dependent kinase that acts as a master regulator of the mitotic and meiotic cell cycles.|||Nucleus http://togogenome.org/gene/284813:ECU11_0070 ^@ http://purl.uniprot.org/uniprot/Q8STG4 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_0930 ^@ http://purl.uniprot.org/uniprot/Q8SWC5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU03_0460 ^@ http://purl.uniprot.org/uniprot/Q8SSB6 ^@ Similarity ^@ Belongs to the sirtuin family. Class I subfamily. http://togogenome.org/gene/284813:ECU11_2020 ^@ http://purl.uniprot.org/uniprot/Q8SQQ9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU11_0400 ^@ http://purl.uniprot.org/uniprot/Q8SU73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SVP26 family.|||Membrane http://togogenome.org/gene/284813:ECU11_2100 ^@ http://purl.uniprot.org/uniprot/Q8ST89 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU11_0910 ^@ http://purl.uniprot.org/uniprot/Q8SU48 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/284813:ECU09_1170 ^@ http://purl.uniprot.org/uniprot/Q8STQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Endoplasmic reticulum membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/284813:ECU09_1275 ^@ http://purl.uniprot.org/uniprot/Q8SQM2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/284813:ECU07_0050 ^@ http://purl.uniprot.org/uniprot/Q8STE6 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_1610 ^@ http://purl.uniprot.org/uniprot/Q8SUV4 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/284813:ECU03_1460 ^@ http://purl.uniprot.org/uniprot/Q8SS77 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of histone H3 leads to transcriptional activation.|||Belongs to the histone H3 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Mono-, di- and trimethylated to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1. H3K36me represses gene expression (By similarity).|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K27ac = acetylated Lys-28; H3K27me1/2/3 = mono-, di- and trimethylated Lys-28; H3K36ac = acetylated Lys-39; H3K36me1/2/3 = mono-, di- and trimethylated Lys-39; H3K56ac = acetylated Lys-58. http://togogenome.org/gene/284813:ECU10_0750 ^@ http://purl.uniprot.org/uniprot/Q8SR45 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_0880 ^@ http://purl.uniprot.org/uniprot/Q8SUE5 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU09_0430 ^@ http://purl.uniprot.org/uniprot/Q8SQP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/284813:ECU09_0450 ^@ http://purl.uniprot.org/uniprot/Q8SQP3 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation of histone H3 leads to transcriptional activation.|||Belongs to the histone H3 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Mono-, di- and trimethylated to form H3K4me1/2/3. H3K4me activates gene expression by regulating transcription elongation and plays a role in telomere length maintenance. H3K4me enrichment correlates with transcription levels, and occurs in a 5' to 3' gradient with H3K4me3 enrichment at the 5'-end of genes, shifting to H3K4me2 and then H3K4me1 (By similarity).|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA.|||To ensure consistency between histone entries, we follow the 'Brno' nomenclature for histone modifications, with positions referring to those used in the literature for the 'closest' model organism. Due to slight variations in histone sequences between organisms and to the presence of initiator methionine in UniProtKB/Swiss-Prot sequences, the actual positions of modified amino acids in the sequence generally differ. In this entry the following conventions are used: H3K4me1/2/3 = mono-, di- and trimethylated Lys-5; H3K9ac = acetylated Lys-10; H3K9me1 = monomethylated Lys-10; H3K14ac = acetylated Lys-15; H3K14me2 = dimethylated Lys-15; H3K18ac = acetylated Lys-19; H3K18me1 = monomethylated Lys-19; H3K23ac = acetylated Lys-24; H3K23me1 = monomethylated Lys-24; H3K56ac = acetylated Lys-56; H3K64ac = acetylated Lys-64. http://togogenome.org/gene/284813:ECU03_1060 ^@ http://purl.uniprot.org/uniprot/Q8SW24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU09_0660 ^@ http://purl.uniprot.org/uniprot/Q8STT9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||Regulates also the sphingolipid metabolism. http://togogenome.org/gene/284813:ECU02_1400 ^@ http://purl.uniprot.org/uniprot/Q8SW96 ^@ Function ^@ Required for 3'-end cleavage and polyadenylation of pre-mRNAs. Also involved in chromosome segregation where it has a role in chromosome attachment to the mitotic spindle. http://togogenome.org/gene/284813:ECU04_1390 ^@ http://purl.uniprot.org/uniprot/Q8SVR4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU01_0970 ^@ http://purl.uniprot.org/uniprot/Q8SSK6 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldo/keto reductase family.|||Catalyzes the NADPH-dependent reduction of a wide variety of carbonyl-containing compounds to their corresponding alcohols with a broad range of catalytic efficiencies.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_1530 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU04_0400 ^@ http://purl.uniprot.org/uniprot/Q8SS62 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HSF family.|||DNA-binding transcription factor that specifically binds heat shock promoter elements (HSE) and activates transcription.|||Homotrimer (By similarity). Homotrimerization increases the affinity of HSF1 to DNA (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU02_0670 ^@ http://purl.uniprot.org/uniprot/Q8SSG7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/284813:ECU08_2120 ^@ http://purl.uniprot.org/uniprot/Q8STG8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU11_0780 ^@ http://purl.uniprot.org/uniprot/Q8SQX3 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS7 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU04_0060 ^@ http://purl.uniprot.org/uniprot/Q8STG8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_0710 ^@ http://purl.uniprot.org/uniprot/Q8STT6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lunapark family.|||Endoplasmic reticulum membrane|||Plays a role in determining ER morphology.|||The C4-type zinc finger motif is necessary both for its ER three-way tubular junction localization and formation. http://togogenome.org/gene/284813:ECU05_1210 ^@ http://purl.uniprot.org/uniprot/Q8SRV4 ^@ Similarity ^@ Belongs to the eukaryotic-type primase large subunit family. http://togogenome.org/gene/284813:ECU06_0250 ^@ http://purl.uniprot.org/uniprot/O76942 ^@ Developmental Stage|||Function|||Subcellular Location Annotation|||Subunit ^@ Found in spores. Expression is high during polar tube formation.|||Interacts with PTP2 and PTP3.|||Involved with PTP2 and PTP3 in the formation of the polar tube through which the infectious agent is passed on to the host cell. Accounts for at least 70 percent of the mass of the polar tube.|||Spore polar tube http://togogenome.org/gene/284813:ECU01_0510 ^@ http://purl.uniprot.org/uniprot/Q8SSM2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NifU family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Component of the core Fe-S cluster (ISC) assembly machinery.|||Mitosome matrix|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitosomes, which is required for maturation of both [2Fe-2S] and [4Fe-4S] proteins (PubMed:18311129). First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISU1. In a second step, the cluster is released from ISU1, transferred to a glutaredoxin, followed by the formation of [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. Cluster assembly on ISU1 depends on the function of the cysteine desulfurase complex NFS1-ISD11, which serves as the sulfur donor for cluster synthesis, the iron-binding protein frataxin as the putative iron donor, and the electron transfer chain comprised of ferredoxin reductase and ferredoxin, which receive their electrons from NADH (By similarity). http://togogenome.org/gene/284813:ECU02_1380 ^@ http://purl.uniprot.org/uniprot/Q8SSD6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/284813:ECU01_0050 ^@ http://purl.uniprot.org/uniprot/P0CT02|||http://purl.uniprot.org/uniprot/P0CT03 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_0130 ^@ http://purl.uniprot.org/uniprot/Q8SW74 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_1250 ^@ http://purl.uniprot.org/uniprot/Q8SW14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/284813:ECU02_1210 ^@ http://purl.uniprot.org/uniprot/Q8SSE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/284813:ECU10_1480 ^@ http://purl.uniprot.org/uniprot/Q8SR09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/KNOX homeobox family.|||Nucleus http://togogenome.org/gene/284813:ECU05_0390 ^@ http://purl.uniprot.org/uniprot/Q8SRZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU11_0760 ^@ http://purl.uniprot.org/uniprot/Q8SQX4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/284813:ECU07_0840 ^@ http://purl.uniprot.org/uniprot/Q8SRJ5 ^@ Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU06_0730 ^@ http://purl.uniprot.org/uniprot/Q8SRR2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Heterodimer of a large and a small subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). http://togogenome.org/gene/284813:ECU05_0690 ^@ http://purl.uniprot.org/uniprot/Q8SVK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Membrane http://togogenome.org/gene/284813:ECU09_1360 ^@ http://purl.uniprot.org/uniprot/Q8SQL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/284813:ECU06_0050 ^@ http://purl.uniprot.org/uniprot/Q8SVF7 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU02_1410 ^@ http://purl.uniprot.org/uniprot/Q8SSD5 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/284813:ECU08_0250 ^@ http://purl.uniprot.org/uniprot/Q8SRF3 ^@ Similarity ^@ Belongs to the V-ATPase H subunit family. http://togogenome.org/gene/284813:ECU10_0030 ^@ http://purl.uniprot.org/uniprot/Q8STJ1 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_0160 ^@ http://purl.uniprot.org/uniprot/Q8SR87 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/284813:ECU01_0460 ^@ http://purl.uniprot.org/uniprot/Q8SWN8 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Actins are highly conserved proteins that are involved in various types of cell motility and are ubiquitously expressed in all eukaryotic cells.|||Belongs to the actin family.|||Expressed in late sporogonial stages.|||cytoskeleton http://togogenome.org/gene/284813:ECU03_0220 ^@ http://purl.uniprot.org/uniprot/Q8SSC9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Component of the T-complex protein 1 (TCP1) complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. http://togogenome.org/gene/284813:ECU10_1680 ^@ http://purl.uniprot.org/uniprot/Q8SR01 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase required for ribosome biogenesis. Involved in the release of U14 snoRNA in pre-ribosomal complexes. Required for pre-rRNA cleavage at site A2 (By similarity).|||Belongs to the DEAD box helicase family. DDX10/DBP4 subfamily.|||Interacts with the U3 and U14 snoRNAs. Associates with pre-ribosomal complexes (By similarity).|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284813:ECU07_1890 ^@ http://purl.uniprot.org/uniprot/Q8ST30 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_1170 ^@ http://purl.uniprot.org/uniprot/Q8SUY1 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/284813:ECU10_1000 ^@ http://purl.uniprot.org/uniprot/Q8SR35 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU11_0770 ^@ http://purl.uniprot.org/uniprot/Q8SU52 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as catalytic component of the CCR4-NOT core complex, which in the nucleus seems to be a general transcription factor, and in the cytoplasm the major mRNA deadenylase involved in mRNA turnover (By similarity). Ccr4 has 3'-5' RNase activity with a strong preference for polyadenylated substrates and also low exonuclease activity towards single-stranded DNA (By similarity).|||Belongs to the CCR4/nocturin family.|||Component of the CCR4-NOT core complex.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU11_1150 ^@ http://purl.uniprot.org/uniprot/Q8SU34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU07_1750 ^@ http://purl.uniprot.org/uniprot/Q8SRG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284813:ECU04_1610 ^@ http://purl.uniprot.org/uniprot/Q8SVP8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic initiation factor 4G family.|||Component of the eIF4F complex, which composition varies with external and internal environmental conditions.|||Component of the protein complex eIF4F, which is involved in the recognition of the mRNA cap, ATP-dependent unwinding of 5'-terminal secondary structure and recruitment of mRNA to the ribosome.|||Cytoplasm http://togogenome.org/gene/284813:ECU06_1300 ^@ http://purl.uniprot.org/uniprot/Q8SV83 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284813:ECU10_1240 ^@ http://purl.uniprot.org/uniprot/Q8SR21 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/284813:ECU06_1080i ^@ http://purl.uniprot.org/uniprot/Q8SRP5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/284813:ECU09_1250 ^@ http://purl.uniprot.org/uniprot/Q8SQM3 ^@ Developmental Stage|||Similarity ^@ Belongs to the universal ribosomal protein uS3 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_0275 ^@ http://purl.uniprot.org/uniprot/Q8SS03 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU07_0110 ^@ http://purl.uniprot.org/uniprot/Q8SRM2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/284813:ECU02_1290 ^@ http://purl.uniprot.org/uniprot/Q8SWA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/284813:ECU10_1470 ^@ http://purl.uniprot.org/uniprot/Q8SUB7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU11_2060 ^@ http://purl.uniprot.org/uniprot/Q8SQQ7 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL29 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_1580 ^@ http://purl.uniprot.org/uniprot/Q8SR04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/284813:ECU11_0040 ^@ http://purl.uniprot.org/uniprot/Q8ST65 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_0520 ^@ http://purl.uniprot.org/uniprot/Q8STV2 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/284813:ECU07_1500 ^@ http://purl.uniprot.org/uniprot/Q8SRH4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284813:ECU01_0110 ^@ http://purl.uniprot.org/uniprot/Q8STB5 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0040 ^@ http://purl.uniprot.org/uniprot/Q8STB5 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_0130 ^@ http://purl.uniprot.org/uniprot/Q8ST53 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU06_0900i ^@ http://purl.uniprot.org/uniprot/Q8SRQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/284813:ECU02_0290 ^@ http://purl.uniprot.org/uniprot/Q8SSI2 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/284813:ECU05_1190 ^@ http://purl.uniprot.org/uniprot/Q8SRV5 ^@ Caution|||Similarity ^@ Belongs to the ABC transporter superfamily. ABCF family. EF3 subfamily.|||Lacks transmembrane domains and is probably not involved in transport. http://togogenome.org/gene/284813:ECU10_0050 ^@ http://purl.uniprot.org/uniprot/Q8ST44 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_1450 ^@ http://purl.uniprot.org/uniprot/Q8SR99 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of most tRNAs using S-adenosyl-L-methionine as donor of the methyl groups.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_1115 ^@ http://purl.uniprot.org/uniprot/Q8SWJ3 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/284813:ECU08_1610 ^@ http://purl.uniprot.org/uniprot/Q8SUL0 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the 60S ribosomal subunit.|||Belongs to the SDO1/SBDS family.|||Cytoplasm|||Expressed in late sporogonial stages.|||May be involved in the biogenesis of the 60S ribosomal subunit and translational activation of ribosomes. http://togogenome.org/gene/284813:ECU06_1700 ^@ http://purl.uniprot.org/uniprot/Q8ST81 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_1870 ^@ http://purl.uniprot.org/uniprot/P0CS97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU01_0870 ^@ http://purl.uniprot.org/uniprot/Q8SSL0 ^@ Developmental Stage|||Similarity ^@ Expressed in late sporogonial stages.|||In the C-terminal section; belongs to the trehalose phosphatase family.|||In the N-terminal section; belongs to the glycosyltransferase 20 family. http://togogenome.org/gene/284813:ECU02_0480 ^@ http://purl.uniprot.org/uniprot/Q8SSH5 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the proteasome subunit S1 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU11_0620 ^@ http://purl.uniprot.org/uniprot/Q95ZE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/284813:ECU03_0290 ^@ http://purl.uniprot.org/uniprot/Q8SSC4 ^@ Domain|||Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Largest and catalytic component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Forms the polymerase active center together with the second largest subunit. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB1 is part of the core element with the central large cleft, the clamp element that moves to open and close the cleft and the jaws that are thought to grab the incoming DNA template. At the start of transcription, a single-stranded DNA template strand of the promoter is positioned within the central active site cleft of Pol II. A bridging helix emanates from RPB1 and crosses the cleft near the catalytic site and is thought to promote translocation of Pol II by acting as a ratchet that moves the RNA-DNA hybrid through the active site by switching from straight to bent conformations at each step of nucleotide addition. During transcription elongation, Pol II moves on the template as the transcript elongates. Elongation is influenced by the phosphorylation status of the C-terminal domain (CTD) of Pol II largest subunit (RPB1), which serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing (By similarity).|||Nucleus|||The C-terminal domain (CTD) serves as a platform for assembly of factors that regulate transcription initiation, elongation, termination and mRNA processing.|||The binding of ribonucleoside triphosphate to the RNA polymerase II transcribing complex probably involves a two-step mechanism. The initial binding seems to occur at the entry (E) site and involves a magnesium ion temporarily coordinated by three conserved aspartate residues of the two largest RNA Pol II subunits. The ribonucleoside triphosphate is transferred by a rotation to the nucleotide addition (A) site for pairing with the template DNA. The catalytic A site involves three conserved aspartate residues of the RNA Pol II largest subunit which permanently coordinate a second magnesium ion.|||The tandem 7 residues repeats in the C-terminal domain (CTD) can be highly phosphorylated. The phosphorylation activates Pol II. Phosphorylation occurs mainly at residues 'Ser-2' and 'Ser-5' of the heptapeptide repeat. The phosphorylation state is believed to result from the balanced action of site-specific CTD kinases and phosphatase, and a 'CTD code' that specifies the position of Pol II within the transcription cycle has been proposed (By similarity). http://togogenome.org/gene/284813:ECU08_0630 ^@ http://purl.uniprot.org/uniprot/Q8SRD5 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/284813:ECU09_0060 ^@ http://purl.uniprot.org/uniprot/Q8STY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Membrane http://togogenome.org/gene/284813:ECU06_0930 ^@ http://purl.uniprot.org/uniprot/Q8SRQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU10_0140 ^@ http://purl.uniprot.org/uniprot/Q8SR82 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/284813:ECU01_0170 ^@ http://purl.uniprot.org/uniprot/O62583 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). http://togogenome.org/gene/284813:ECU07_0820 ^@ http://purl.uniprot.org/uniprot/Q8SRJ7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/284813:ECU10_1300 ^@ http://purl.uniprot.org/uniprot/Q8SR18 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL42 family. http://togogenome.org/gene/284813:ECU02_1430 ^@ http://purl.uniprot.org/uniprot/Q8SW94 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II.|||Cytoplasm|||Nucleus|||Small GTPase required for proper nuclear import of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/284813:ECU08_1200 ^@ http://purl.uniprot.org/uniprot/Q8SUN7 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/284813:ECU06_1680 ^@ http://purl.uniprot.org/uniprot/Q8SV57 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU02_0100 ^@ http://purl.uniprot.org/uniprot/Q8SWH2 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_1540 ^@ http://purl.uniprot.org/uniprot/Q8SVZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU09_1610 ^@ http://purl.uniprot.org/uniprot/Q8STM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/284813:ECU05_1040 ^@ http://purl.uniprot.org/uniprot/Q8SVI9 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0600 ^@ http://purl.uniprot.org/uniprot/Q8SW51 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU11_1460 ^@ http://purl.uniprot.org/uniprot/Q8SQT7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome (By similarity).|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU05_0040 ^@ http://purl.uniprot.org/uniprot/Q8STE8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_2100 ^@ http://purl.uniprot.org/uniprot/Q8ST97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU11_0820 ^@ http://purl.uniprot.org/uniprot/Q8SQX0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Nucleus|||Required both for recombination and for the repair of DNA damage caused by X-rays. http://togogenome.org/gene/284813:ECU06_0360 ^@ http://purl.uniprot.org/uniprot/Q8SRS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU01_0800 ^@ http://purl.uniprot.org/uniprot/Q8SSL2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 20 family.|||Component of the trehalose synthase complex.|||Cytoplasm|||Expressed in late sporogonial stages.|||Synthase catalytic subunit of the trehalose synthase complex that catalyzes the production of trehalose from glucose-6-phosphate and UDP-alpha-D-glucose in a two step process. Can function independently of the complex (By similarity). http://togogenome.org/gene/284813:ECU08_1430 ^@ http://purl.uniprot.org/uniprot/Q8SUM3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/284813:ECU03_0500 ^@ http://purl.uniprot.org/uniprot/Q8SSB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/284813:ECU01_0430 ^@ http://purl.uniprot.org/uniprot/Q8SSM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage factor I (CF I) involved in pre-mRNA 3'-end processing.|||Nucleus http://togogenome.org/gene/284813:ECU10_1170 ^@ http://purl.uniprot.org/uniprot/Q8SR26 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU04_0740 ^@ http://purl.uniprot.org/uniprot/Q8SS49 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL22 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU09_0770 ^@ http://purl.uniprot.org/uniprot/Q8SQN5 ^@ Similarity ^@ Belongs to the DNA polymerase delta/II small subunit family. http://togogenome.org/gene/284813:ECU06_0670 ^@ http://purl.uniprot.org/uniprot/Q8SVC0 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU02_1180 ^@ http://purl.uniprot.org/uniprot/Q8SWA8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU06_0030 ^@ http://purl.uniprot.org/uniprot/Q8STJ4 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU05_1590 ^@ http://purl.uniprot.org/uniprot/Q8SQI1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA glycosylase MPG family.|||Expressed in late sporogonial stages.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions.|||Nucleus http://togogenome.org/gene/284813:ECU05_0885 ^@ http://purl.uniprot.org/uniprot/Q8SRW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Heterotrimeric complex composed of SEC61-alpha, SEC61-beta and SEC61-gamma.|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/284813:ECU08_1190 ^@ http://purl.uniprot.org/uniprot/Q8SUN8 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/284813:ECU10_1080 ^@ http://purl.uniprot.org/uniprot/Q8SR32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/284813:ECU01_1240 ^@ http://purl.uniprot.org/uniprot/Q8SWI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/284813:ECU11_1830 ^@ http://purl.uniprot.org/uniprot/Q8SQR8 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Required for normal growth at various temperatures. http://togogenome.org/gene/284813:ECU04_0890 ^@ http://purl.uniprot.org/uniprot/Q8SS41 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/284813:ECU02_0310 ^@ http://purl.uniprot.org/uniprot/Q8SWF6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with pre-60S ribosomal particles; released from the pre-60S particle very early in the cytoplasm.|||Belongs to the ZNF593/BUD20 C2H2-type zinc-finger protein family.|||Cytoplasm|||Involved in pre-60S ribosomal particles maturation by promoting the nuclear export of the 60S ribosome.|||Nucleus http://togogenome.org/gene/284813:ECU11_2070 ^@ http://purl.uniprot.org/uniprot/Q8SQH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/284813:ECU08_1850 ^@ http://purl.uniprot.org/uniprot/Q8SR89 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the rate-limiting step of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis (By similarity).|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU10_1770i ^@ http://purl.uniprot.org/uniprot/Q8SQZ7 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M17 family.|||Binds 2 Zn(2+) ions per subunit.|||Cytoplasm|||Expressed in late sporogonial stages.|||Homohexamer.|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides (By similarity). http://togogenome.org/gene/284813:ECU04_0780 ^@ http://purl.uniprot.org/uniprot/Q8SS47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. Is also involved in ribosome biogenesis. Associates with pre-60S subunits in the nucleus and is involved in its nuclear export.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284813:ECU09_0670 ^@ http://purl.uniprot.org/uniprot/Q8SQN9 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 1 subfamily. http://togogenome.org/gene/284813:ECU03_0280 ^@ http://purl.uniprot.org/uniprot/Q8SSC5 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Expressed in late sporogonial stages.|||Homooctamer.|||Plays a central role as a glucosyl donor in cellular metabolic pathways. http://togogenome.org/gene/284813:ECU09_1520 ^@ http://purl.uniprot.org/uniprot/Q8STN3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine at position 1191 (Psi1191) in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi) conserved in eukaryotic 18S rRNA.|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/284813:ECU01_0360 ^@ http://purl.uniprot.org/uniprot/Q8SWP6 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/284813:ECU09_1800 ^@ http://purl.uniprot.org/uniprot/Q8SQK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Chromosome|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Nucleus http://togogenome.org/gene/284813:ECU09_0980 ^@ http://purl.uniprot.org/uniprot/Q8SQM9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284813:ECU06_0440 ^@ http://purl.uniprot.org/uniprot/Q8SVD6 ^@ Similarity ^@ Belongs to the RNase Z family. http://togogenome.org/gene/284813:ECU03_0340 ^@ http://purl.uniprot.org/uniprot/Q8SW65 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/284813:ECU11_0090 ^@ http://purl.uniprot.org/uniprot/Q8STF1 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU10_1570i ^@ http://purl.uniprot.org/uniprot/Q8SR06 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/284813:ECU10_0540 ^@ http://purl.uniprot.org/uniprot/Q8SUF9 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP transporter involved in the uptake of ATP from the host cell cytoplasm. Provides the microsporidian cell with host ATP in exchange for ADP. This is an obligate exchange system. This energy acquiring activity is an important component of microsporidian parasitism.|||Belongs to the ADP/ATP translocase tlc family.|||Cell membrane|||Expressed in all stages of development including spores. http://togogenome.org/gene/284813:ECU07_1630 ^@ http://purl.uniprot.org/uniprot/Q8SUV3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/284813:ECU09_2020 ^@ http://purl.uniprot.org/uniprot/Q8STE6 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_1390 ^@ http://purl.uniprot.org/uniprot/Q8SW05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Cytoplasm http://togogenome.org/gene/284813:ECU09_0820 ^@ http://purl.uniprot.org/uniprot/Q8STS8 ^@ Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Component of the septin complex.|||Expressed in late sporogonial stages.|||Septins are GTPases involved in cytokinesis. The septins localize to the site of cleavage and act as a structural scaffold that recruits different components involved in diverse processes at specific stages during the cell cycle. Septins are also involved in cell morphogenesis, chitin deposition, cell cycle regulation, cell compartmentalization and spore wall formation (By similarity). http://togogenome.org/gene/284813:ECU10_0900 ^@ http://purl.uniprot.org/uniprot/Q8SUE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/284813:ECU02_1080 ^@ http://purl.uniprot.org/uniprot/Q8SWB3 ^@ Similarity ^@ In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/284813:ECU05_0260 ^@ http://purl.uniprot.org/uniprot/Q8SVM5 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/284813:ECU03_0900 ^@ http://purl.uniprot.org/uniprot/Q8SS97 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the STXBP/unc-18/SEC1 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Expressed in late sporogonial stages.|||Golgi stack membrane|||Involved in vesicular transport between the endoplasmic reticulum and the Golgi. http://togogenome.org/gene/284813:ECU05_0520 ^@ http://purl.uniprot.org/uniprot/Q8SVL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/284813:ECU07_0100 ^@ http://purl.uniprot.org/uniprot/Q8SV52 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/284813:ECU09_1030 ^@ http://purl.uniprot.org/uniprot/Q8STR3 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/284813:ECU05_0360 ^@ http://purl.uniprot.org/uniprot/Q8SRZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm http://togogenome.org/gene/284813:ECU06_0080 ^@ http://purl.uniprot.org/uniprot/Q8SVF4 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0870 ^@ http://purl.uniprot.org/uniprot/Q8SRB9 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS4 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_1440 ^@ http://purl.uniprot.org/uniprot/Q8SS78 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/284813:ECU02_1100 ^@ http://purl.uniprot.org/uniprot/Q8SSE8 ^@ Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 90 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Homodimer.|||Molecular chaperone that promotes the maturation, structural maintenance and proper regulation of specific target proteins involved in cell cycle control and signal transduction. Undergoes a functional cycle that is linked to its ATPase activity. The nucleotide-free form of the dimer is found in an open conformation in which the N-termini are not dimerized and the complex is ready for client protein binding. Binding of ATP induces large conformational changes, resulting in the formation of a ring-like closed structure in which the N-terminal domains associate intramolecularly with the middle domain and also dimerize with each other, stimulating their intrinsic ATPase activity and acting as a clamp on the substrate. Finally, ATP hydrolysis results in the release of the substrate. This cycle probably induces conformational changes in the client proteins, thereby causing their activation. Interacts dynamically with various co-chaperones that modulate its substrate recognition, ATPase cycle and chaperone function. Required for growth at high temperatures (By similarity).|||The TPR repeat-binding motif mediates interaction with TPR repeat-containing proteins. http://togogenome.org/gene/284813:ECU08_2090 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU05_0340 ^@ http://purl.uniprot.org/uniprot/Q8SVM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BCAP29/BCAP31 family.|||Endoplasmic reticulum membrane|||May play a role in anterograde transport of membrane proteins from the endoplasmic reticulum to the Golgi.|||Membrane http://togogenome.org/gene/284813:ECU03_0800 ^@ http://purl.uniprot.org/uniprot/Q8SW42 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3 homolog UBA4. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Prior mcm(5) tRNA modification by the elongator complex is required for 2-thiolation. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins such as AHP1. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of UBA4, then thiocarboxylated (-COSH) via the rhodanese domain of UBA4.|||Cytoplasm http://togogenome.org/gene/284813:ECU06_0210 ^@ http://purl.uniprot.org/uniprot/Q8SRT3 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/284813:ECU08_0010 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU02_1590 ^@ http://purl.uniprot.org/uniprot/Q8STG8 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_1140 ^@ http://purl.uniprot.org/uniprot/Q8SSE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/284813:ECU07_1830 ^@ http://purl.uniprot.org/uniprot/Q8SQH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/284813:ECU10_1400 ^@ http://purl.uniprot.org/uniprot/Q8SUC0 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/284813:ECU08_0030 ^@ http://purl.uniprot.org/uniprot/Q8ST94 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU05_0090 ^@ http://purl.uniprot.org/uniprot/Q8SS09 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small GTPase superfamily. SAR1 family.|||COPII is composed of at least 5 proteins: the SEC23/24 complex, the SEC13/31 complex and SAR1.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Expressed in late sporogonial stages.|||Golgi apparatus membrane|||Small GTPase component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules. SAR1 controls the coat assembly in a stepwise manner. Activated SAR1-GTP binds to membranes first and recruits the SEC23/24 complex. These SEC23/24-SAR1 prebudding intermediates are then collected by the SEC13/31 complex as subunits polymerize to form coated transport vesicles. Conversion to SAR1-GDP triggers coat release and recycles COPII subunits (By similarity). http://togogenome.org/gene/284813:ECU06_1120 ^@ http://purl.uniprot.org/uniprot/Q8SRP1 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL36 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU02_1150 ^@ http://purl.uniprot.org/uniprot/Q8SSE5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284813:ECU02_0020 ^@ http://purl.uniprot.org/uniprot/Q8ST35 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU01_1010 ^@ http://purl.uniprot.org/uniprot/Q8SSK3 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family.|||Catalyzes the covalent attachment of ubiquitin to other proteins so as to signal them for selective protein degradation. Involved in the formation of multiubiquitin chains.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_1440 ^@ http://purl.uniprot.org/uniprot/Q8SUW6 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/284813:ECU10_0380 ^@ http://purl.uniprot.org/uniprot/Q8SR66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||Monomer.|||Nucleus|||mRNA-capping methyltransferase that methylates the N7 position of the added guanosine to the 5'-cap structure of mRNAs. Binds RNA containing 5'-terminal GpppC. http://togogenome.org/gene/284813:ECU07_1700 ^@ http://purl.uniprot.org/uniprot/Q8SRG6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/284813:ECU10_0800 ^@ http://purl.uniprot.org/uniprot/Q8SUF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the N(1) position of adenine in helix 25.1 in 25S rRNA. Required both for ribosomal 40S and 60S subunits biogenesis. Required for efficient pre-rRNA cleavage at site A2.|||nucleolus http://togogenome.org/gene/284813:ECU07_1870 ^@ http://purl.uniprot.org/uniprot/Q8STJ1 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU05_1540 ^@ http://purl.uniprot.org/uniprot/Q8SRT7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the proteasome subunit S3 family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU01_1270 ^@ http://purl.uniprot.org/uniprot/Q8SWI4 ^@ Developmental Stage|||Function|||Subcellular Location Annotation ^@ Cytoplasm|||Expressed during all sporogonic stages.|||Membrane|||Spore wall|||Spore wall component. http://togogenome.org/gene/284813:ECU05_0730 ^@ http://purl.uniprot.org/uniprot/Q8SRX7 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/284813:ECU07_0900 ^@ http://purl.uniprot.org/uniprot/Q8SV02 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/284813:ECU02_1060 ^@ http://purl.uniprot.org/uniprot/Q8SSF0 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/284813:ECU07_0690 ^@ http://purl.uniprot.org/uniprot/Q8SV13 ^@ Similarity ^@ Belongs to the iron/ascorbate-dependent oxidoreductase family. http://togogenome.org/gene/284813:ECU11_1410 ^@ http://purl.uniprot.org/uniprot/Q8SU22 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EST3 family.|||Component of the telomerase complex involved in telomere replication. Stimulates RNA/DNA heteroduplex unwinding which favors the telomere replication by the telomerase.|||Nucleus|||telomere http://togogenome.org/gene/284813:ECU10_1860 ^@ http://purl.uniprot.org/uniprot/Q8SU91 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_0100 ^@ http://purl.uniprot.org/uniprot/Q8ST94 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU09_0640 ^@ http://purl.uniprot.org/uniprot/Q8SQP0 ^@ Developmental Stage|||Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Expressed in late sporogonial stages.|||Homotetramer. http://togogenome.org/gene/284813:ECU11_1350 ^@ http://purl.uniprot.org/uniprot/Q8SQU4 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/284813:ECU06_0040 ^@ http://purl.uniprot.org/uniprot/Q8SVF8 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_0500 ^@ http://purl.uniprot.org/uniprot/Q8SWN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284813:ECU10_1210 ^@ http://purl.uniprot.org/uniprot/Q8SR23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||DNA polymerase II participates in chromosomal DNA replication.|||Nucleus http://togogenome.org/gene/284813:ECU09_1590 ^@ http://purl.uniprot.org/uniprot/Q8STM7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Has a role in transport between endoplasmic reticulum and Golgi.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/284813:ECU07_0980 ^@ http://purl.uniprot.org/uniprot/Q8SUZ5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Component of the 2-(3-amino-3-carboxypropyl)histidine synthase complex composed of DPH1, DPH2, DPH3 and a NADH-dependent reductase, predominantly CBR1.|||Cytoplasm http://togogenome.org/gene/284813:ECU11_0370 ^@ http://purl.uniprot.org/uniprot/Q8SQY8 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/284813:ECU09_0910 ^@ http://purl.uniprot.org/uniprot/Q8SQN2 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/284813:ECU11_0570 ^@ http://purl.uniprot.org/uniprot/Q8SQY3 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the peptidase M67A family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU05_1370 ^@ http://purl.uniprot.org/uniprot/Q8SRU4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU02_1370 ^@ http://purl.uniprot.org/uniprot/Q8SQJ2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 37 family. http://togogenome.org/gene/284813:ECU05_1070 ^@ http://purl.uniprot.org/uniprot/Q8SVI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family.|||Cytoplasm|||Required for the final endonucleolytic cleavage at site D converting 20S pre-rRNA into the mature 18S rRNA. Required for the final steps of cytoplasmic maturation of the 40S ribosomal subunit. Despite the protein kinase domain is proposed to act predominantly as an ATPase. Has a role in the cell cycle where it is required for entrance into S-phase and in the control of the onset of anaphase. Appears to also be involved in the maintenance of chromosome stability and correct mitotic segregation (By similarity). http://togogenome.org/gene/284813:ECU10_0580 ^@ http://purl.uniprot.org/uniprot/Q8SUF8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/284813:ECU11_1380i ^@ http://purl.uniprot.org/uniprot/Q8SQU2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/284813:ECU07_0520 ^@ http://purl.uniprot.org/uniprot/Q8SRK8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/284813:ECU11_0080 ^@ http://purl.uniprot.org/uniprot/P0CT00|||http://purl.uniprot.org/uniprot/P0CT01 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_0520 ^@ http://purl.uniprot.org/uniprot/Q8SUG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP transporter involved in the uptake of ATP from the parasite cell cytoplasm into the mitosome matrix. Equilibrates nucleotide pools across a concentration gradient between both sides of the mitosome membrane.|||Belongs to the ADP/ATP translocase tlc family.|||Mitosome membrane http://togogenome.org/gene/284813:ECU04_0830 ^@ http://purl.uniprot.org/uniprot/Q8SVU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP4 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU11_0450 ^@ http://purl.uniprot.org/uniprot/Q8SQY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts on phosphatidylinositol (PI) in the first committed step in the production of the second messenger inositol 1,4,5,-trisphosphate.|||Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily.|||Cytoplasm http://togogenome.org/gene/284813:ECU10_1290 ^@ http://purl.uniprot.org/uniprot/Q8SUC6 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/284813:ECU09_1890 ^@ http://purl.uniprot.org/uniprot/Q8SQJ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/284813:ECU07_1190 ^@ http://purl.uniprot.org/uniprot/Q8SRI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/284813:ECU10_1660 ^@ http://purl.uniprot.org/uniprot/Q9XZV1 ^@ Developmental Stage|||Function|||Miscellaneous|||Subcellular Location Annotation ^@ Preferentially synthesized during differentiation from meronts to sporonts in early sporogony.|||SWP1 is a major antigen recognized during host infection and might be a target for microsporidian infection diagnosis in the case of immunocompetent persons.|||Spore wall component.|||perispore http://togogenome.org/gene/284813:ECU10_0020 ^@ http://purl.uniprot.org/uniprot/Q8STD6 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU01_1490 ^@ http://purl.uniprot.org/uniprot/Q8STB3 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU05_0060 ^@ http://purl.uniprot.org/uniprot/Q8SS10 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/284813:ECU11_1550i ^@ http://purl.uniprot.org/uniprot/Q8SQT2 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/284813:ECU11_0190 ^@ http://purl.uniprot.org/uniprot/Q8SQZ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_1060 ^@ http://purl.uniprot.org/uniprot/Q8SR33 ^@ Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. http://togogenome.org/gene/284813:ECU05_0980 ^@ http://purl.uniprot.org/uniprot/Q8SVJ1 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/284813:ECU02_1220 ^@ http://purl.uniprot.org/uniprot/Q8SSE3 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/284813:ECU07_1340 ^@ http://purl.uniprot.org/uniprot/Q8SRI0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/284813:ECU10_1690 ^@ http://purl.uniprot.org/uniprot/Q8SUA4 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/284813:ECU06_1530 ^@ http://purl.uniprot.org/uniprot/Q8SRM7 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the NDK family.|||Expressed in late sporogonial stages.|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate (By similarity). http://togogenome.org/gene/284813:ECU08_1350 ^@ http://purl.uniprot.org/uniprot/Q8SRA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU10_1720 ^@ http://purl.uniprot.org/uniprot/Q8SQZ9 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/284813:ECU11_0200 ^@ http://purl.uniprot.org/uniprot/Q8SU88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus http://togogenome.org/gene/284813:ECU03_0700 ^@ http://purl.uniprot.org/uniprot/Q8SW47 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/284813:ECU10_1710 ^@ http://purl.uniprot.org/uniprot/Q8SUA2 ^@ Similarity ^@ Belongs to the HIT family. http://togogenome.org/gene/284813:ECU02_1050 ^@ http://purl.uniprot.org/uniprot/Q8SWB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAC-alpha family.|||Cytoplasm|||May be involved in mitochondrial protein import by enhancing productive ribosome interactions with the outer mitochondrial membrane and blocks the inappropriate interaction of ribosomes translating non-secretory nascent polypeptides with translocation sites in the membrane of the endoplasmic reticulum. EGD2 may also be involved in transcription regulation (By similarity).|||Nucleus http://togogenome.org/gene/284813:ECU01_1410 ^@ http://purl.uniprot.org/uniprot/Q8SQI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Membrane http://togogenome.org/gene/284813:ECU06_1390 ^@ http://purl.uniprot.org/uniprot/Q8SV76 ^@ Similarity ^@ Belongs to the NEMF family. http://togogenome.org/gene/284813:ECU04_0090 ^@ http://purl.uniprot.org/uniprot/Q8STE0 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU08_0540 ^@ http://purl.uniprot.org/uniprot/Q8SUS0 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU09_1600 ^@ http://purl.uniprot.org/uniprot/Q8SQL0 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/284813:ECU10_0690 ^@ http://purl.uniprot.org/uniprot/Q8SR49 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-binding RNA helicase involved in the biogenesis of 60S ribosomal subunits. Binds 90S pre-ribosomal particles and dissociates from pre-60S ribosomal particles after processing of 27SB pre-rRNA. Required for the normal formation of 18S rRNA through the processing of pre-rRNAs at sites A0, A1 and A2, and the normal formation of 25S and 5.8S rRNAs through the processing of pre-rRNAs at sites C1 and C2.|||Belongs to the DEAD box helicase family. DDX55/SPB4 subfamily.|||Component of pre-60S ribosomal complexes.|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis.|||nucleolus http://togogenome.org/gene/284813:ECU05_0050 ^@ http://purl.uniprot.org/uniprot/Q8SVN9 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU05_0800 ^@ http://purl.uniprot.org/uniprot/Q8SVJ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/284813:ECU11_1870 ^@ http://purl.uniprot.org/uniprot/Q8SQR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. MFSD6 family.|||Membrane http://togogenome.org/gene/284813:ECU10_0280 ^@ http://purl.uniprot.org/uniprot/Q8SUH2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Interacts with TAN1.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires the tRNA-binding adapter protein TAN1 for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/284813:ECU04_0820 ^@ http://purl.uniprot.org/uniprot/Q8SS43 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/284813:ECU02_0440 ^@ http://purl.uniprot.org/uniprot/Q8SSH7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutathione peroxidase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Protects cells and enzymes from oxidative damage, by catalyzing the reduction of hydrogen peroxide, lipid peroxides and organic hydroperoxide, by glutathione. http://togogenome.org/gene/284813:ECU11_1100 ^@ http://purl.uniprot.org/uniprot/Q8SQV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU07_0360 ^@ http://purl.uniprot.org/uniprot/Q8SRL5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||Nucleus|||Required for high-fidelity chromosome segregation during the later part of each cell cycle. Has a role in attaching the kinetochores to the microtubules and ensuring that sister kinetochores connect to opposite poles. The promotion of bi-orientation is achieved by selectively detaching kinetochore-microtubule attachments that are not under tension (By similarity).|||kinetochore|||spindle http://togogenome.org/gene/284813:ECU09_1070 ^@ http://purl.uniprot.org/uniprot/Q8SQM7 ^@ Function|||Similarity ^@ Belongs to the peptidase C13 family.|||Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. http://togogenome.org/gene/284813:ECU11_0360 ^@ http://purl.uniprot.org/uniprot/Q8SU76 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity).|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/284813:ECU10_0790 ^@ http://purl.uniprot.org/uniprot/Q8SUF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/284813:ECU08_1260 ^@ http://purl.uniprot.org/uniprot/Q8SRA5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_0610 ^@ http://purl.uniprot.org/uniprot/Q8SUF7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/284813:ECU01_1520 ^@ http://purl.uniprot.org/uniprot/Q8ST67 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_1570 ^@ http://purl.uniprot.org/uniprot/Q8ST97 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU02_0260 ^@ http://purl.uniprot.org/uniprot/Q8SSI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU09_0560 ^@ http://purl.uniprot.org/uniprot/Q8STU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/284813:ECU08_2010 ^@ http://purl.uniprot.org/uniprot/Q8SR84 ^@ Developmental Stage|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_0090 ^@ http://purl.uniprot.org/uniprot/Q8SRG2 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/284813:ECU09_0930 ^@ http://purl.uniprot.org/uniprot/Q8STS1 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/284813:ECU01_0630 ^@ http://purl.uniprot.org/uniprot/Q8SWM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC5/Polo subfamily.|||Protein kinase required for the cell cycle where it is involved in mitotic exit. Required to form a bipolar spindle, the actin ring and septum. Functions upstream of the whole septum formation pathway, including actin ring formation (regulated by late septation genes) and septal material deposition (regulated by early septation genes). Behaves as a 'septum-promoting factor', and could also be involved in inducing other late events of cell division (By similarity).|||spindle pole body http://togogenome.org/gene/284813:ECU06_0190 ^@ http://purl.uniprot.org/uniprot/Q8SRT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/284813:ECU11_0050 ^@ http://purl.uniprot.org/uniprot/Q8STA9 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_0180 ^@ http://purl.uniprot.org/uniprot/Q8SR79 ^@ Similarity ^@ Belongs to the ribose 5-phosphate isomerase family. http://togogenome.org/gene/284813:ECU08_0765 ^@ http://purl.uniprot.org/uniprot/Q8SRC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284813:ECU06_0070 ^@ http://purl.uniprot.org/uniprot/Q8SVF5 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU05_1610 ^@ http://purl.uniprot.org/uniprot/Q8ST42 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU04_1080 ^@ http://purl.uniprot.org/uniprot/Q8SVT0 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU02_1090 ^@ http://purl.uniprot.org/uniprot/Q8SSE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU10_0120 ^@ http://purl.uniprot.org/uniprot/Q8SR83 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDC7 subfamily.|||Serine/threonine-protein kinase. Needed for the initiation of DNA synthesis during mitosis as well as for synaptonemal complex formation and commitment to recombination during meiosis (By similarity). http://togogenome.org/gene/284813:ECU05_0140 ^@ http://purl.uniprot.org/uniprot/Q8SVN2 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU02_1490 ^@ http://purl.uniprot.org/uniprot/Q8SSD4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/284813:ECU04_0380 ^@ http://purl.uniprot.org/uniprot/Q8SVW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/284813:ECU09_0720 ^@ http://purl.uniprot.org/uniprot/Q8SQN7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU08_0050 ^@ http://purl.uniprot.org/uniprot/Q8STB3 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU04_0850 ^@ http://purl.uniprot.org/uniprot/Q8SS42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/284813:ECU10_0960 ^@ http://purl.uniprot.org/uniprot/Q8SUE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity. May be involved in rRNA maturation and transcription regulation.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/284813:ECU09_1470 ^@ http://purl.uniprot.org/uniprot/Q8STN7 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU08_1090 ^@ http://purl.uniprot.org/uniprot/Q8SUP3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalytic tRNA acetyltransferase subunit of the elongator complex, which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). In the elongator complex, acts as a tRNA uridine(34) acetyltransferase by mediating formation of carboxymethyluridine in the wobble base at position 34 in tRNAs. http://togogenome.org/gene/284813:ECU10_0510 ^@ http://purl.uniprot.org/uniprot/Q8SR61 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family. http://togogenome.org/gene/284813:ECU08_0070 ^@ http://purl.uniprot.org/uniprot/Q8SRG3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/284813:ECU04_1650 ^@ http://purl.uniprot.org/uniprot/Q8SVP4 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU09_1730 ^@ http://purl.uniprot.org/uniprot/Q8STL7 ^@ Similarity ^@ Belongs to the CDC73 family. http://togogenome.org/gene/284813:ECU10_0840 ^@ http://purl.uniprot.org/uniprot/Q8SUE8 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/284813:ECU11_0390 ^@ http://purl.uniprot.org/uniprot/Q8SU74 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/284813:ECU10_0920 ^@ http://purl.uniprot.org/uniprot/Q8SR37 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Heterodimer of a large and a small subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).|||Under complex allosteric control mediated by deoxynucleoside triphosphates and ATP binding to separate specificity and activation sites on the large subunit. The type of nucleotide bound at the specificity site determines substrate preference. It seems probable that ATP makes the enzyme reduce CDP and UDP, dGTP favors ADP reduction and dTTP favors GDP reduction. Stimulated by ATP and inhibited by dATP binding to the activity site (By similarity). http://togogenome.org/gene/284813:ECU02_0060 ^@ http://purl.uniprot.org/uniprot/Q8SWH6 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_0950 ^@ http://purl.uniprot.org/uniprot/Q8SUE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/284813:ECU01_0470 ^@ http://purl.uniprot.org/uniprot/Q8SSM3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU09_0920 ^@ http://purl.uniprot.org/uniprot/Q8SQN1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/284813:ECU01_1000 ^@ http://purl.uniprot.org/uniprot/Q8SSK4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/284813:ECU08_0290 ^@ http://purl.uniprot.org/uniprot/Q8SRF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/284813:ECU03_0670 ^@ http://purl.uniprot.org/uniprot/Q8SSA4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/284813:ECU11_1620i ^@ http://purl.uniprot.org/uniprot/Q8SQS8 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||Component of the small ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU06_0020 ^@ http://purl.uniprot.org/uniprot/Q8ST81 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU09_1880 ^@ http://purl.uniprot.org/uniprot/Q8STL0 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU04_1440 ^@ http://purl.uniprot.org/uniprot/Q8ST28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/284813:ECU03_0360 ^@ http://purl.uniprot.org/uniprot/Q8SSB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/284813:ECU07_1120 ^@ http://purl.uniprot.org/uniprot/Q8SUY5 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU11_0530 ^@ http://purl.uniprot.org/uniprot/O96771 ^@ Developmental Stage|||Similarity|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Expressed in late sporogonial stages.|||Homodimer. http://togogenome.org/gene/284813:ECU01_0330 ^@ http://purl.uniprot.org/uniprot/Q8SWP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||nucleolus http://togogenome.org/gene/284813:ECU03_0680 ^@ http://purl.uniprot.org/uniprot/Q8SSA3 ^@ Similarity ^@ Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Eukaryotic two domain clade "E" sub-subfamily. http://togogenome.org/gene/284813:ECU11_0220 ^@ http://purl.uniprot.org/uniprot/Q8SQZ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU08_0020 ^@ http://purl.uniprot.org/uniprot/Q8ST67 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU08_1400 ^@ http://purl.uniprot.org/uniprot/Q8SUM6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU01_0840 ^@ http://purl.uniprot.org/uniprot/Q8SWL2 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU11_0930i ^@ http://purl.uniprot.org/uniprot/Q8SQW4 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/284813:ECU02_1350 ^@ http://purl.uniprot.org/uniprot/Q8SSD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/284813:ECU01_0400 ^@ http://purl.uniprot.org/uniprot/Q8SWP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Membrane|||Probably involved in transport through the plasma membrane. http://togogenome.org/gene/284813:ECU01_1310 ^@ http://purl.uniprot.org/uniprot/Q8SWI3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the frataxin family.|||Mitosome|||Monomer.|||Promotes the assembly and repair of iron-sulfur clusters by delivering Fe(2+) to proteins involved in these pathways. http://togogenome.org/gene/284813:ECU09_0630 ^@ http://purl.uniprot.org/uniprot/Q8STU1 ^@ Function|||Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/284813:ECU10_1760 ^@ http://purl.uniprot.org/uniprot/Q8SQZ8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/284813:ECU03_1190 ^@ http://purl.uniprot.org/uniprot/Q8SS85 ^@ Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Expressed in late sporogonial stages.|||Homodimer; disulfide-linked, upon oxidation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this typical 2-Cys peroxiredoxin, C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides and as sensor of hydrogen peroxide-mediated signaling events. http://togogenome.org/gene/284813:ECU11_1290 ^@ http://purl.uniprot.org/uniprot/Q8SQU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||May play a role in the control of the eukaryotic cell cycle.|||Nucleus http://togogenome.org/gene/284813:ECU05_0510 ^@ http://purl.uniprot.org/uniprot/Q8SVL5 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU01_0090 ^@ http://purl.uniprot.org/uniprot/Q8ST67 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU11_1930 ^@ http://purl.uniprot.org/uniprot/Q8STZ8 ^@ Function ^@ The SPT4-SPT5 complex mediates both activation and inhibition of transcription elongation, and plays a role in pre-mRNA processing. This complex seems to be important for the stability of the RNA polymerase II elongation machinery on the chromatin template but not for the inherent ability of this machinery to translocate down the gene. http://togogenome.org/gene/284813:ECU08_1510 ^@ http://purl.uniprot.org/uniprot/Q8SUL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/284813:ECU07_0960 ^@ http://purl.uniprot.org/uniprot/Q8SRJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/284813:ECU11_1450 ^@ http://purl.uniprot.org/uniprot/Q8SQT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||nuclear pore complex http://togogenome.org/gene/284813:ECU11_1610 ^@ http://purl.uniprot.org/uniprot/Q8SQS9 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/284813:ECU04_1150 ^@ http://purl.uniprot.org/uniprot/Q8SVS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/284813:ECU05_1100 ^@ http://purl.uniprot.org/uniprot/Q8SVI4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation. http://togogenome.org/gene/284813:ECU04_0900 ^@ http://purl.uniprot.org/uniprot/Q8SS40 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/284813:ECU11_1090 ^@ http://purl.uniprot.org/uniprot/Q8SU38 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ERF4 family.|||Endoplasmic reticulum membrane|||Interacts with ERF2. http://togogenome.org/gene/284813:ECU04_1310 ^@ http://purl.uniprot.org/uniprot/Q8SS18 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/284813:ECU07_1380 ^@ http://purl.uniprot.org/uniprot/Q8SRH8 ^@ Function|||Similarity ^@ Component of the 60S subunit of the ribosome.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/284813:ECU01_0420 ^@ http://purl.uniprot.org/uniprot/Q8SWP1 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SWP12 family.|||Expressed in late sporogonial stages.|||Spore wall http://togogenome.org/gene/284813:ECU06_0240 ^@ http://purl.uniprot.org/uniprot/Q8SRT0 ^@ Developmental Stage|||Function|||Subcellular Location Annotation|||Subunit ^@ Expressed in late sporogonial stages.|||Interacts with PTP1 and PTP3.|||Involved in formation of a polar tube through which the infectious agent is passed on to the host cell.|||Spore polar tube http://togogenome.org/gene/284813:ECU10_0270 ^@ http://purl.uniprot.org/uniprot/Q8SR73 ^@ Similarity ^@ Belongs to the RNase PH family. http://togogenome.org/gene/284813:ECU09_0490 ^@ http://purl.uniprot.org/uniprot/Q8STV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||nuclear pore complex http://togogenome.org/gene/284813:ECU01_0670 ^@ http://purl.uniprot.org/uniprot/Q8SWM3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to TFIIK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module TFIIK controls the initiation of transcription.|||Nucleus http://togogenome.org/gene/284813:ECU05_0160 ^@ http://purl.uniprot.org/uniprot/Q8SS08 ^@ Similarity ^@ Belongs to the amino acid/polyamine transporter 2 family. http://togogenome.org/gene/284813:ECU08_1480 ^@ http://purl.uniprot.org/uniprot/Q8SR98 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/284813:ECU04_0980 ^@ http://purl.uniprot.org/uniprot/Q8SS36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Cytoplasm http://togogenome.org/gene/284813:ECU01_0180 ^@ http://purl.uniprot.org/uniprot/O62584 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/284813:ECU07_0860 ^@ http://purl.uniprot.org/uniprot/Q8SRJ4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/284813:ECU05_0560 ^@ http://purl.uniprot.org/uniprot/Q8SVL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/284813:ECU03_1270 ^@ http://purl.uniprot.org/uniprot/Q8SS83 ^@ Similarity ^@ Belongs to the cytidylate kinase family. Type 1 subfamily. http://togogenome.org/gene/284813:ECU05_1340 ^@ http://purl.uniprot.org/uniprot/Q8SRU7 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity).|||The proteasome degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. It has an ATP-dependent proteolytic activity (By similarity). http://togogenome.org/gene/284813:ECU11_0120 ^@ http://purl.uniprot.org/uniprot/Q8ST42 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU03_1490 ^@ http://purl.uniprot.org/uniprot/Q8SS76 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/284813:ECU08_1080 ^@ http://purl.uniprot.org/uniprot/Q8SRB2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent RNA helicase involved nonsense-mediated mRNA decay and ribosome biogenesis through rRNA processing.|||Associates with polysomes.|||Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily.|||Cytoplasm|||Nucleus|||The Q motif is unique to and characteristic of the DEAD box family of RNA helicases and controls ATP binding and hydrolysis. http://togogenome.org/gene/284813:ECU01_1320 ^@ http://purl.uniprot.org/uniprot/Q8SSJ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/284813:ECU07_1850 ^@ http://purl.uniprot.org/uniprot/Q8ST44 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU10_1090 ^@ http://purl.uniprot.org/uniprot/Q8SUD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ING family.|||Nucleus http://togogenome.org/gene/284813:ECU08_0900 ^@ http://purl.uniprot.org/uniprot/Q8SRB6 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/284813:ECU06_1040 ^@ http://purl.uniprot.org/uniprot/Q8SRP6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. Active with Co(2+), Fe(2+), Mn(2+) and Zn(2+).|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/284813:ECU10_1640 ^@ http://purl.uniprot.org/uniprot/Q8SR02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU02_0430 ^@ http://purl.uniprot.org/uniprot/Q8SSH8 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/284813:ECU10_0810 ^@ http://purl.uniprot.org/uniprot/Q8SUE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex, which consists of at least NDC80 and NUF2.|||Nucleus|||kinetochore http://togogenome.org/gene/284813:ECU10_1070 ^@ http://purl.uniprot.org/uniprot/Q8SUD4 ^@ Developmental Stage ^@ Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU02_0730 ^@ http://purl.uniprot.org/uniprot/Q8SSG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/284813:ECU09_1680 ^@ http://purl.uniprot.org/uniprot/Q8SQK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/284813:ECU04_0600 ^@ http://purl.uniprot.org/uniprot/Q8SS55 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/284813:ECU10_0620 ^@ http://purl.uniprot.org/uniprot/Q8SR54 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Active in protein import into the nucleus.|||Belongs to the importin beta family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus http://togogenome.org/gene/284813:ECU07_0320 ^@ http://purl.uniprot.org/uniprot/Q8SRL8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/284813:ECU08_0230 ^@ http://purl.uniprot.org/uniprot/Q8SRF5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||May play a role in the control of the eukaryotic cell cycle.|||Nucleus http://togogenome.org/gene/284813:ECU09_1790 ^@ http://purl.uniprot.org/uniprot/Q8SQK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/284813:ECU09_1390 ^@ http://purl.uniprot.org/uniprot/Q8STP2 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RuvB family.|||Component of the SWR1 chromatin remodeling complex, the INO80 chromatin remodeling complex, and of the R2TP complex.|||DNA helicase which participates in several chromatin remodeling complexes, including the SWR1 and the INO80 complexes. The SWR1 complex mediates the ATP-dependent exchange of histone H2A for the H2A variant HZT1 leading to transcriptional regulation of selected genes by chromatin remodeling. The INO80 complex remodels chromatin by shifting nucleosomes and is involved in DNA repair. Also involved in pre-rRNA processing (By similarity).|||Expressed in late sporogonial stages.|||Nucleus http://togogenome.org/gene/284813:ECU07_1350 ^@ http://purl.uniprot.org/uniprot/Q8SRH9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex (components: a, c, c', c'', d, e, f and VOA1). The decameric c-ring forms the proton-conducting pore, and is composed of eight proteolipid subunits c, one subunit c' and one subunit c''. http://togogenome.org/gene/284813:ECU11_1030 ^@ http://purl.uniprot.org/uniprot/Q8SQV9 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/284813:ECU02_1470 ^@ http://purl.uniprot.org/uniprot/Q8SW90 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Expressed in late sporogonial stages.|||Membrane http://togogenome.org/gene/284813:ECU04_1030 ^@ http://purl.uniprot.org/uniprot/Q8SVT3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/284813:ECU05_0970 ^@ http://purl.uniprot.org/uniprot/Q8SVJ2 ^@ Function|||Similarity ^@ Belongs to the NARF family.|||Component of the cytosolic Fe/S protein assembly machinery. May play a role in the transfer of pre-assembled Fe/S clusters to target apoproteins (By similarity). http://togogenome.org/gene/284813:ECU05_0650 ^@ http://purl.uniprot.org/uniprot/Q8SRY1 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GPI family.|||Expressed in late sporogonial stages.|||Homodimer.|||In the cytoplasm, catalyzes the conversion of glucose-6-phosphate to fructose-6-phosphate, the second step in glycolysis, and the reverse reaction during gluconeogenesis.|||cytosol http://togogenome.org/gene/284813:ECU06_0790 ^@ http://purl.uniprot.org/uniprot/Q8SRQ8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/284813:ECU03_0020 ^@ http://purl.uniprot.org/uniprot/Q8SW84 ^@ Similarity ^@ Belongs to the UPF0328 family. http://togogenome.org/gene/284813:ECU07_1410 ^@ http://purl.uniprot.org/uniprot/Q8SRH7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/284813:ECU06_1030 ^@ http://purl.uniprot.org/uniprot/Q8SRP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 2 subfamily.|||nucleolus http://togogenome.org/gene/284813:ECU02_0080 ^@ http://purl.uniprot.org/uniprot/Q8SWH4 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU03_0620 ^@ http://purl.uniprot.org/uniprot/Q8SSA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily.|||Nucleus|||Serine/threonine-protein kinase which is required for checkpoint-mediated cell cycle arrest and activation of DNA repair in response to the presence of DNA damage or unreplicated DNA. May also negatively regulate cell cycle progression during unperturbed cell cycles (By similarity). http://togogenome.org/gene/284813:ECU07_1880 ^@ http://purl.uniprot.org/uniprot/Q8STD6 ^@ Similarity ^@ Belongs to the UPF0329 family. http://togogenome.org/gene/284813:ECU07_1310 ^@ http://purl.uniprot.org/uniprot/Q8SUX2 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/284813:ECU11_0660 ^@ http://purl.uniprot.org/uniprot/Q8SQX8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/284813:ECU01_0610 ^@ http://purl.uniprot.org/uniprot/Q8SSL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ELP2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/284813:ECU11_0590 ^@ http://purl.uniprot.org/uniprot/Q8SQY2 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/284813:ECU02_0510 ^@ http://purl.uniprot.org/uniprot/Q8SSH4 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.|||Involved in the regulation of the onset of mitosis. Involved in a pathway that coordinates cell proliferation and differentiation. Implicated in spindle pole body (SPD) duplication. Dual specificity kinase that can phosphorylate serine, threonine and tyrosine residues (By similarity). http://togogenome.org/gene/284813:ECU05_0440 ^@ http://purl.uniprot.org/uniprot/Q8SRZ0 ^@ Cofactor|||Developmental Stage|||Similarity ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Binds 2 manganese ions per subunit.|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU03_0760 ^@ http://purl.uniprot.org/uniprot/Q8SW46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NCBP2 family.|||Nucleus http://togogenome.org/gene/284813:ECU08_1790 ^@ http://purl.uniprot.org/uniprot/Q8SR90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||May play a role in the control of the eukaryotic cell cycle.|||Nucleus http://togogenome.org/gene/284813:ECU09_1350 ^@ http://purl.uniprot.org/uniprot/Q8SQL9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/284813:ECU07_1005 ^@ http://purl.uniprot.org/uniprot/Q8SRJ2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL43 family. http://togogenome.org/gene/284813:ECU07_1820 ^@ http://purl.uniprot.org/uniprot/Q8ST62 ^@ Developmental Stage|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uL29 family.|||Component of the large ribosomal subunit.|||Cytoplasm|||Expressed in late sporogonial stages. http://togogenome.org/gene/284813:ECU07_1640 ^@ http://purl.uniprot.org/uniprot/Q8SRH0 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a regulatory subunit of the 26S proteasome which degrades poly-ubiquitinated proteins in the cytoplasm and in the nucleus. It is essential for the regulated turnover of proteins and for the removal of misfolded proteins. The proteasome is a multicatalytic proteinase complex that is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH (By similarity).|||Belongs to the AAA ATPase family.|||Cytoplasm|||Expressed in late sporogonial stages.|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. The 20S proteasome core is composed of 28 subunits that are arranged in four stacked rings, resulting in a barrel-shaped structure. The two end rings are each formed by seven alpha subunits, and the two central rings are each formed by seven beta subunits. The catalytic chamber with the active sites is on the inside of the barrel (By similarity). http://togogenome.org/gene/284813:ECU03_1080 ^@ http://purl.uniprot.org/uniprot/Q8SS91 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm