http://togogenome.org/gene/333146:FACI_RS05985 ^@ http://purl.uniprot.org/uniprot/S0AQF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/333146:FACI_RS05390 ^@ http://purl.uniprot.org/uniprot/S0AQ48 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/333146:FACI_RS02515 ^@ http://purl.uniprot.org/uniprot/S0AQX5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/333146:FACI_RS04825 ^@ http://purl.uniprot.org/uniprot/S0ASE7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/333146:FACI_RS02315 ^@ http://purl.uniprot.org/uniprot/S0AQJ5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS07890 ^@ http://purl.uniprot.org/uniprot/S0AQQ2 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/333146:FACI_RS06665 ^@ http://purl.uniprot.org/uniprot/S0AQW2 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/333146:FACI_RS02520 ^@ http://purl.uniprot.org/uniprot/S0ANJ6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/333146:FACI_RS05345 ^@ http://purl.uniprot.org/uniprot/S0AP53 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/333146:FACI_RS05680 ^@ http://purl.uniprot.org/uniprot/S0ASW1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS07785 ^@ http://purl.uniprot.org/uniprot/S0ARW4 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/333146:FACI_RS00045 ^@ http://purl.uniprot.org/uniprot/S0AP67 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/333146:FACI_RS01830 ^@ http://purl.uniprot.org/uniprot/S0AQ98 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS08620 ^@ http://purl.uniprot.org/uniprot/S0ARU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/333146:FACI_RS00565 ^@ http://purl.uniprot.org/uniprot/S0AMW4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/333146:FACI_RS03025 ^@ http://purl.uniprot.org/uniprot/S0ANV8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/333146:FACI_RS07650 ^@ http://purl.uniprot.org/uniprot/S0AQJ2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS01175 ^@ http://purl.uniprot.org/uniprot/S0APU5 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/333146:FACI_RS05110 ^@ http://purl.uniprot.org/uniprot/S0AQ02 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05650 ^@ http://purl.uniprot.org/uniprot/S0APB8 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/333146:FACI_RS06355 ^@ http://purl.uniprot.org/uniprot/S0AT57 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS01180 ^@ http://purl.uniprot.org/uniprot/S0AQA1 ^@ Similarity|||Subunit ^@ Belongs to the CarB family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/333146:FACI_RS04275 ^@ http://purl.uniprot.org/uniprot/S0APM9 ^@ Similarity ^@ Belongs to the BCKDHA family. http://togogenome.org/gene/333146:FACI_RS04745 ^@ http://purl.uniprot.org/uniprot/S0AS41 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/333146:FACI_RS05660 ^@ http://purl.uniprot.org/uniprot/S0ASQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS00755 ^@ http://purl.uniprot.org/uniprot/S0AM99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS00015 ^@ http://purl.uniprot.org/uniprot/S0AKU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/333146:FACI_RS07240 ^@ http://purl.uniprot.org/uniprot/S0AQB4 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/333146:FACI_RS03075 ^@ http://purl.uniprot.org/uniprot/S0ANX0 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/333146:FACI_RS07140 ^@ http://purl.uniprot.org/uniprot/S0AR40 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/333146:FACI_RS03670 ^@ http://purl.uniprot.org/uniprot/S0APP7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/333146:FACI_RS03325 ^@ http://purl.uniprot.org/uniprot/S0ARC7 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/333146:FACI_RS09145 ^@ http://purl.uniprot.org/uniprot/S0ASR0 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/333146:FACI_RS01395 ^@ http://purl.uniprot.org/uniprot/S0AND3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05395 ^@ http://purl.uniprot.org/uniprot/S0AQL7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family.|||Cytoplasm|||Specifically methylates the uridine in position 2552 of 23S rRNA at the 2'-O position of the ribose in the fully assembled 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS09805 ^@ http://purl.uniprot.org/uniprot/S0AQZ2 ^@ Caution|||Function|||Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS04935 ^@ http://purl.uniprot.org/uniprot/S0APX8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/333146:FACI_RS04575 ^@ http://purl.uniprot.org/uniprot/S0APT2 ^@ Function|||Similarity ^@ Belongs to the type-2 OGG1 family.|||Catalyzes the excision of an oxidatively damaged form of guanine (7,8-dihydro-8-oxoguanine = 8-oxoG) from DNA. Also cleaves the DNA backbone at apurinic/apyrimidinic sites (AP sites). http://togogenome.org/gene/333146:FACI_RS05460 ^@ http://purl.uniprot.org/uniprot/S0ASQ7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/333146:FACI_RS08280 ^@ http://purl.uniprot.org/uniprot/S0ATV5 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/333146:FACI_RS01735 ^@ http://purl.uniprot.org/uniprot/S0AQM2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/333146:FACI_RS09450 ^@ http://purl.uniprot.org/uniprot/S0AU47 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/333146:FACI_RS08995 ^@ http://purl.uniprot.org/uniprot/S0AS42 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/333146:FACI_RS08240 ^@ http://purl.uniprot.org/uniprot/S0ATT6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS00480 ^@ http://purl.uniprot.org/uniprot/S0APT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetate uptake transporter (AceTr) (TC 2.A.96) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS06105 ^@ http://purl.uniprot.org/uniprot/S0AT40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/333146:FACI_RS01585 ^@ http://purl.uniprot.org/uniprot/S0AQJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS01380 ^@ http://purl.uniprot.org/uniprot/S0APZ1 ^@ Similarity ^@ Belongs to the DMRL synthase family. http://togogenome.org/gene/333146:FACI_RS06245 ^@ http://purl.uniprot.org/uniprot/S0AR36 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/333146:FACI_RS04690 ^@ http://purl.uniprot.org/uniprot/S0ASC7 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/333146:FACI_RS05685 ^@ http://purl.uniprot.org/uniprot/S0ASR2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/333146:FACI_RS02685 ^@ http://purl.uniprot.org/uniprot/S0ANN2 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/333146:FACI_RS06370 ^@ http://purl.uniprot.org/uniprot/S0APR9 ^@ Similarity ^@ Belongs to the UPF0179 family. http://togogenome.org/gene/333146:FACI_RS03290 ^@ http://purl.uniprot.org/uniprot/S0AN02 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/333146:FACI_RS09385 ^@ http://purl.uniprot.org/uniprot/S0AU33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/333146:FACI_RS05045 ^@ http://purl.uniprot.org/uniprot/S0AP02 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/333146:FACI_RS05910 ^@ http://purl.uniprot.org/uniprot/S0AQX2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Membrane http://togogenome.org/gene/333146:FACI_RS06260 ^@ http://purl.uniprot.org/uniprot/S0AT37 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS01655 ^@ http://purl.uniprot.org/uniprot/S0AQ74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS01185 ^@ http://purl.uniprot.org/uniprot/S0AMJ3 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/333146:FACI_RS05415 ^@ http://purl.uniprot.org/uniprot/S0AQ53 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS05215 ^@ http://purl.uniprot.org/uniprot/S0AQ19 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/333146:FACI_RS02590 ^@ http://purl.uniprot.org/uniprot/S0ANL3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/333146:FACI_RS08145 ^@ http://purl.uniprot.org/uniprot/S0ARL3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS05355 ^@ http://purl.uniprot.org/uniprot/S0ASI5 ^@ Function ^@ The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/333146:FACI_RS07825 ^@ http://purl.uniprot.org/uniprot/S0ATQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/333146:FACI_RS02755 ^@ http://purl.uniprot.org/uniprot/S0ANP7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/333146:FACI_RS04425 ^@ http://purl.uniprot.org/uniprot/S0APQ1 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruD family.|||Could be responsible for synthesis of pseudouridine from uracil-13 in transfer RNAs. http://togogenome.org/gene/333146:FACI_RS05050 ^@ http://purl.uniprot.org/uniprot/S0ASI7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS06680 ^@ http://purl.uniprot.org/uniprot/S0ATE6 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/333146:FACI_RS08305 ^@ http://purl.uniprot.org/uniprot/S0ATV6 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/333146:FACI_RS01210 ^@ http://purl.uniprot.org/uniprot/S0AMK2 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/333146:FACI_RS07570 ^@ http://purl.uniprot.org/uniprot/S0ARA3 ^@ Similarity ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIIA subfamily. http://togogenome.org/gene/333146:FACI_RS04520 ^@ http://purl.uniprot.org/uniprot/S0AS01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS03890 ^@ http://purl.uniprot.org/uniprot/S0APF4 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/333146:FACI_RS00610 ^@ http://purl.uniprot.org/uniprot/S0AM68 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family.|||Binds 1 Mn(2+) ion per subunit.|||Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP), the rate-limiting step in the metabolic pathway that produces glucose from lactate and other precursors derived from the citric acid cycle.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS03655 ^@ http://purl.uniprot.org/uniprot/S0ARF7 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/333146:FACI_RS06310 ^@ http://purl.uniprot.org/uniprot/S0AT43 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/333146:FACI_RS08985 ^@ http://purl.uniprot.org/uniprot/S0AU10 ^@ Similarity ^@ Belongs to the SfsA family. http://togogenome.org/gene/333146:FACI_RS07515 ^@ http://purl.uniprot.org/uniprot/S0ATL8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/333146:FACI_RS01500 ^@ http://purl.uniprot.org/uniprot/S0ALX3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/333146:FACI_RS02205 ^@ http://purl.uniprot.org/uniprot/S0AQS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/333146:FACI_RS05240 ^@ http://purl.uniprot.org/uniprot/S0AQ21 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/333146:FACI_RS04405 ^@ http://purl.uniprot.org/uniprot/S0AQ50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic CoaD family.|||Cytoplasm|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/333146:FACI_RS07160 ^@ http://purl.uniprot.org/uniprot/S0ATK0 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/333146:FACI_RS01535 ^@ http://purl.uniprot.org/uniprot/S0AQI9 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/333146:FACI_RS02180 ^@ http://purl.uniprot.org/uniprot/S0AQS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/333146:FACI_RS08265 ^@ http://purl.uniprot.org/uniprot/S0ATT7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS01225 ^@ http://purl.uniprot.org/uniprot/S0APV4 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/333146:FACI_RS05500 ^@ http://purl.uniprot.org/uniprot/S0AQP4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/333146:FACI_RS05255 ^@ http://purl.uniprot.org/uniprot/S0ASM0 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/333146:FACI_RS04525 ^@ http://purl.uniprot.org/uniprot/S0APS3 ^@ Similarity ^@ Belongs to the UMP kinase family. http://togogenome.org/gene/333146:FACI_RS08425 ^@ http://purl.uniprot.org/uniprot/S0ATV4 ^@ Similarity ^@ Belongs to the site-specific recombinase resolvase family. http://togogenome.org/gene/333146:FACI_RS03570 ^@ http://purl.uniprot.org/uniprot/S0APM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/333146:FACI_RS03770 ^@ http://purl.uniprot.org/uniprot/S0AN93 ^@ Function|||Similarity ^@ Belongs to the NOP10 family.|||Involved in ribosome biogenesis; more specifically in 18S rRNA pseudouridylation and in cleavage of pre-rRNA. http://togogenome.org/gene/333146:FACI_RS07625 ^@ http://purl.uniprot.org/uniprot/S0AQI5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS04160 ^@ http://purl.uniprot.org/uniprot/S0ANJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate.|||Homodimer. http://togogenome.org/gene/333146:FACI_RS03495 ^@ http://purl.uniprot.org/uniprot/S0AN43 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/333146:FACI_RS06320 ^@ http://purl.uniprot.org/uniprot/S0AR47 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS08955 ^@ http://purl.uniprot.org/uniprot/S0AU08 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/333146:FACI_RS00150 ^@ http://purl.uniprot.org/uniprot/S0AMN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06545 ^@ http://purl.uniprot.org/uniprot/S0APW3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/333146:FACI_RS04110 ^@ http://purl.uniprot.org/uniprot/S0AS36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DNA polymerase II family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3'- to 5'-direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/333146:FACI_RS03650 ^@ http://purl.uniprot.org/uniprot/S0AN68 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05610 ^@ http://purl.uniprot.org/uniprot/S0ASP6 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 2 family. http://togogenome.org/gene/333146:FACI_RS08980 ^@ http://purl.uniprot.org/uniprot/S0ARH7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/333146:FACI_RS04630 ^@ http://purl.uniprot.org/uniprot/S0ANS5 ^@ Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family. http://togogenome.org/gene/333146:FACI_RS04495 ^@ http://purl.uniprot.org/uniprot/S0ARZ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05185 ^@ http://purl.uniprot.org/uniprot/S0ASE0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS05595 ^@ http://purl.uniprot.org/uniprot/S0AQR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Membrane http://togogenome.org/gene/333146:FACI_RS07360 ^@ http://purl.uniprot.org/uniprot/S0ARN9 ^@ Function|||Similarity ^@ Belongs to the GTP-dependent DPCK family.|||Catalyzes the GTP-dependent phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A (CoA). http://togogenome.org/gene/333146:FACI_RS06280 ^@ http://purl.uniprot.org/uniprot/S0AT72 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS09235 ^@ http://purl.uniprot.org/uniprot/S0AU28 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/333146:FACI_RS04600 ^@ http://purl.uniprot.org/uniprot/S0APT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/333146:FACI_RS08665 ^@ http://purl.uniprot.org/uniprot/S0ATX6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/333146:FACI_RS04940 ^@ http://purl.uniprot.org/uniprot/S0AQC9 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/333146:FACI_RS07480 ^@ http://purl.uniprot.org/uniprot/S0ATN3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/333146:FACI_RS08475 ^@ http://purl.uniprot.org/uniprot/S0ASB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS03295 ^@ http://purl.uniprot.org/uniprot/S0AR79 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/333146:FACI_RS09435 ^@ http://purl.uniprot.org/uniprot/S0ASC1 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/333146:FACI_RS03320 ^@ http://purl.uniprot.org/uniprot/S0AR84 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/333146:FACI_RS06140 ^@ http://purl.uniprot.org/uniprot/S0AQI8 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS05690 ^@ http://purl.uniprot.org/uniprot/S0AQA5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/333146:FACI_RS01605 ^@ http://purl.uniprot.org/uniprot/S0AQ67 ^@ Similarity ^@ Belongs to the HepT RNase toxin family. http://togogenome.org/gene/333146:FACI_RS00810 ^@ http://purl.uniprot.org/uniprot/S0ALC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/333146:FACI_RS06330 ^@ http://purl.uniprot.org/uniprot/S0AT78 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS00805 ^@ http://purl.uniprot.org/uniprot/S0AN18 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/333146:FACI_RS04540 ^@ http://purl.uniprot.org/uniprot/S0ASA2 ^@ Similarity ^@ Belongs to the AAA ATPase family. CDC48 subfamily. http://togogenome.org/gene/333146:FACI_RS06080 ^@ http://purl.uniprot.org/uniprot/S0ASZ7 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/333146:FACI_RS01965 ^@ http://purl.uniprot.org/uniprot/S0AM66 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/333146:FACI_RS04880 ^@ http://purl.uniprot.org/uniprot/S0AS75 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/333146:FACI_RS09275 ^@ http://purl.uniprot.org/uniprot/S0AST3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06025 ^@ http://purl.uniprot.org/uniprot/S0AT27 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/333146:FACI_RS03385 ^@ http://purl.uniprot.org/uniprot/S0APH8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/333146:FACI_RS05510 ^@ http://purl.uniprot.org/uniprot/S0ASR7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/333146:FACI_RS08885 ^@ http://purl.uniprot.org/uniprot/S0AU00 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/333146:FACI_RS06100 ^@ http://purl.uniprot.org/uniprot/S0APK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/333146:FACI_RS06795 ^@ http://purl.uniprot.org/uniprot/S0ARE2 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/333146:FACI_RS02075 ^@ http://purl.uniprot.org/uniprot/S0AQQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/333146:FACI_RS06420 ^@ http://purl.uniprot.org/uniprot/S0APT1 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/333146:FACI_RS05835 ^@ http://purl.uniprot.org/uniprot/S0ASV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS03450 ^@ http://purl.uniprot.org/uniprot/S0ARB7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/333146:FACI_RS03420 ^@ http://purl.uniprot.org/uniprot/S0ARA9 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/333146:FACI_RS05055 ^@ http://purl.uniprot.org/uniprot/S0ASB4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/333146:FACI_RS08180 ^@ http://purl.uniprot.org/uniprot/S0AQY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS03560 ^@ http://purl.uniprot.org/uniprot/S0ARI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/333146:FACI_RS02675 ^@ http://purl.uniprot.org/uniprot/S0AQS5 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/333146:FACI_RS03185 ^@ http://purl.uniprot.org/uniprot/S0ANZ2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/333146:FACI_RS00330 ^@ http://purl.uniprot.org/uniprot/S0APC7 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/333146:FACI_RS01635 ^@ http://purl.uniprot.org/uniprot/S0AQK6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS04120 ^@ http://purl.uniprot.org/uniprot/S0APL0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/333146:FACI_RS05340 ^@ http://purl.uniprot.org/uniprot/S0AQK9 ^@ Similarity ^@ Belongs to the anthranilate synthase component I family. http://togogenome.org/gene/333146:FACI_RS04800 ^@ http://purl.uniprot.org/uniprot/S0APW0 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/333146:FACI_RS00865 ^@ http://purl.uniprot.org/uniprot/S0AN28 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06035 ^@ http://purl.uniprot.org/uniprot/S0AQG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/333146:FACI_RS00315 ^@ http://purl.uniprot.org/uniprot/S0AM12 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/333146:FACI_RS05920 ^@ http://purl.uniprot.org/uniprot/S0ASW8 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/333146:FACI_RS02585 ^@ http://purl.uniprot.org/uniprot/S0AQY9 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/333146:FACI_RS03040 ^@ http://purl.uniprot.org/uniprot/S0AR13 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/333146:FACI_RS04610 ^@ http://purl.uniprot.org/uniprot/S0ASB3 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/333146:FACI_RS07940 ^@ http://purl.uniprot.org/uniprot/S0ATS7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS04295 ^@ http://purl.uniprot.org/uniprot/S0ARX0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/333146:FACI_RS01385 ^@ http://purl.uniprot.org/uniprot/S0AQE9 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/333146:FACI_RS03145 ^@ http://purl.uniprot.org/uniprot/S0APC2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/333146:FACI_RS06625 ^@ http://purl.uniprot.org/uniprot/S0APX9 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/333146:FACI_RS07025 ^@ http://purl.uniprot.org/uniprot/S0ATG4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS03330 ^@ http://purl.uniprot.org/uniprot/S0AP21 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/333146:FACI_RS04055 ^@ http://purl.uniprot.org/uniprot/S0APJ9 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/333146:FACI_RS02065 ^@ http://purl.uniprot.org/uniprot/S0AM87 ^@ Similarity ^@ Belongs to the carbamate kinase family. http://togogenome.org/gene/333146:FACI_RS09230 ^@ http://purl.uniprot.org/uniprot/S0ARL4 ^@ Similarity ^@ Belongs to the aspartate/glutamate racemases family. http://togogenome.org/gene/333146:FACI_RS01150 ^@ http://purl.uniprot.org/uniprot/S0ALK7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS03765 ^@ http://purl.uniprot.org/uniprot/S0APR6 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/333146:FACI_RS03575 ^@ http://purl.uniprot.org/uniprot/S0AN56 ^@ Similarity ^@ Belongs to the ComB family. http://togogenome.org/gene/333146:FACI_RS01775 ^@ http://purl.uniprot.org/uniprot/S0AM24 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/333146:FACI_RS04590 ^@ http://purl.uniprot.org/uniprot/S0ASB0 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/333146:FACI_RS01125 ^@ http://purl.uniprot.org/uniprot/S0ALK0 ^@ Similarity ^@ Belongs to the MoaD family. http://togogenome.org/gene/333146:FACI_RS00675 ^@ http://purl.uniprot.org/uniprot/S0APX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/333146:FACI_RS03730 ^@ http://purl.uniprot.org/uniprot/S0ARM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/333146:FACI_RS03945 ^@ http://purl.uniprot.org/uniprot/S0ANF5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/333146:FACI_RS02070 ^@ http://purl.uniprot.org/uniprot/S0AQF5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/333146:FACI_RS03490 ^@ http://purl.uniprot.org/uniprot/S0APK2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/333146:FACI_RS03615 ^@ http://purl.uniprot.org/uniprot/S0AP85 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/333146:FACI_RS00145 ^@ http://purl.uniprot.org/uniprot/S0ALX6 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS09440 ^@ http://purl.uniprot.org/uniprot/S0ASW0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07215 ^@ http://purl.uniprot.org/uniprot/S0ATJ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/333146:FACI_RS07395 ^@ http://purl.uniprot.org/uniprot/S0ATM8 ^@ Similarity ^@ Belongs to the ferrochelatase family. http://togogenome.org/gene/333146:FACI_RS07995 ^@ http://purl.uniprot.org/uniprot/S0ATR9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06340 ^@ http://purl.uniprot.org/uniprot/S0AR52 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/333146:FACI_RS07870 ^@ http://purl.uniprot.org/uniprot/S0ATS0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structurs that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA. http://togogenome.org/gene/333146:FACI_RS01710 ^@ http://purl.uniprot.org/uniprot/S0AQL8 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/333146:FACI_RS06495 ^@ http://purl.uniprot.org/uniprot/S0APV5 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/333146:FACI_RS07270 ^@ http://purl.uniprot.org/uniprot/S0AQB9 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/333146:FACI_RS03645 ^@ http://purl.uniprot.org/uniprot/S0APP1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06905 ^@ http://purl.uniprot.org/uniprot/S0ATE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/333146:FACI_RS02740 ^@ http://purl.uniprot.org/uniprot/S0AMN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/333146:FACI_RS05655 ^@ http://purl.uniprot.org/uniprot/S0ASV6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/333146:FACI_RS06235 ^@ http://purl.uniprot.org/uniprot/S0AT30 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/333146:FACI_RS08090 ^@ http://purl.uniprot.org/uniprot/S0ATS6 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/333146:FACI_RS05225 ^@ http://purl.uniprot.org/uniprot/S0AP30 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/333146:FACI_RS05780 ^@ http://purl.uniprot.org/uniprot/S0ASY4 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/333146:FACI_RS04530 ^@ http://purl.uniprot.org/uniprot/S0AQ68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Directs the termination of nascent peptide synthesis (translation) in response to the termination codons UAA, UAG and UGA.|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/333146:FACI_RS03485 ^@ http://purl.uniprot.org/uniprot/S0AP55 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS04640 ^@ http://purl.uniprot.org/uniprot/S0AS21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/333146:FACI_RS05505 ^@ http://purl.uniprot.org/uniprot/S0AP88 ^@ Similarity ^@ Belongs to the HAM1 NTPase family. http://togogenome.org/gene/333146:FACI_RS01115 ^@ http://purl.uniprot.org/uniprot/S0AMH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07935 ^@ http://purl.uniprot.org/uniprot/S0AQR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS03760 ^@ http://purl.uniprot.org/uniprot/S0APC0 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/333146:FACI_RS05735 ^@ http://purl.uniprot.org/uniprot/S0ASS3 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS05005 ^@ http://purl.uniprot.org/uniprot/S0ASA4 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/333146:FACI_RS01740 ^@ http://purl.uniprot.org/uniprot/S0AMZ7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS08595 ^@ http://purl.uniprot.org/uniprot/S0ARU5 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS03455 ^@ http://purl.uniprot.org/uniprot/S0ARG5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/333146:FACI_RS03620 ^@ http://purl.uniprot.org/uniprot/S0APN4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/333146:FACI_RS05630 ^@ http://purl.uniprot.org/uniprot/S0ASU8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/333146:FACI_RS00510 ^@ http://purl.uniprot.org/uniprot/S0AM46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/333146:FACI_RS08310 ^@ http://purl.uniprot.org/uniprot/S0ATU2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SUA5 family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/333146:FACI_RS00020 ^@ http://purl.uniprot.org/uniprot/S0AP60 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/333146:FACI_RS09480 ^@ http://purl.uniprot.org/uniprot/S0AU40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/333146:FACI_RS09510 ^@ http://purl.uniprot.org/uniprot/S0ASX1 ^@ Similarity ^@ In the C-terminal section; belongs to the prokaryotic molybdopterin-containing oxidoreductase family. http://togogenome.org/gene/333146:FACI_RS02395 ^@ http://purl.uniprot.org/uniprot/S0ANG5 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/333146:FACI_RS00800 ^@ http://purl.uniprot.org/uniprot/S0AMA9 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the geranylgeranyl reductase family. DGGGPL reductase subfamily.|||Binds 1 FAD per subunit.|||Is involved in the reduction of 2,3-digeranylgeranylglycerophospholipids (unsaturated archaeols) into 2,3-diphytanylglycerophospholipids (saturated archaeols) in the biosynthesis of archaeal membrane lipids. Catalyzes the formation of archaetidic acid (2,3-di-O-phytanyl-sn-glyceryl phosphate) from 2,3-di-O-geranylgeranylglyceryl phosphate (DGGGP) via the hydrogenation of each double bond of the isoprenoid chains.|||Reduction reaction proceeds via syn addition of hydrogen for double bonds. http://togogenome.org/gene/333146:FACI_RS05805 ^@ http://purl.uniprot.org/uniprot/S0ASY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05745 ^@ http://purl.uniprot.org/uniprot/S0AQT7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of alpha (SecY), beta (SecG) and gamma (SecE) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/333146:FACI_RS05840 ^@ http://purl.uniprot.org/uniprot/S0AQD2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/333146:FACI_RS05490 ^@ http://purl.uniprot.org/uniprot/S0ASL8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/333146:FACI_RS05135 ^@ http://purl.uniprot.org/uniprot/S0ASD0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS05080 ^@ http://purl.uniprot.org/uniprot/S0ASB9 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS01090 ^@ http://purl.uniprot.org/uniprot/S0AMH0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05860 ^@ http://purl.uniprot.org/uniprot/S0ASV9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/333146:FACI_RS07665 ^@ http://purl.uniprot.org/uniprot/S0ARC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IA subfamily.|||Cell membrane|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit is responsible for energy coupling to the transport system and for the release of the potassium ions to the cytoplasm.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/333146:FACI_RS02600 ^@ http://purl.uniprot.org/uniprot/S0AMJ5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/333146:FACI_RS08060 ^@ http://purl.uniprot.org/uniprot/S0ATT9 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/333146:FACI_RS01340 ^@ http://purl.uniprot.org/uniprot/S0AMM9 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/333146:FACI_RS09455 ^@ http://purl.uniprot.org/uniprot/S0AU38 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily.|||Catalyzes the conversion of GDP-D-mannose to GDP-4-dehydro-6-deoxy-D-mannose.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS05030 ^@ http://purl.uniprot.org/uniprot/S0ASA8 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/333146:FACI_RS07425 ^@ http://purl.uniprot.org/uniprot/S0ATL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05855 ^@ http://purl.uniprot.org/uniprot/S0ASZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta chain family.|||Cytoplasm|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/333146:FACI_RS08030 ^@ http://purl.uniprot.org/uniprot/S0AQU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/333146:FACI_RS07370 ^@ http://purl.uniprot.org/uniprot/S0ATM3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/333146:FACI_RS04820 ^@ http://purl.uniprot.org/uniprot/S0ANW6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/333146:FACI_RS05890 ^@ http://purl.uniprot.org/uniprot/S0AT04 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/333146:FACI_RS01670 ^@ http://purl.uniprot.org/uniprot/S0ANJ9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS09645 ^@ http://purl.uniprot.org/uniprot/S0ASG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/333146:FACI_RS06585 ^@ http://purl.uniprot.org/uniprot/S0AQV2 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS01450 ^@ http://purl.uniprot.org/uniprot/S0ALV6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/333146:FACI_RS06985 ^@ http://purl.uniprot.org/uniprot/S0ARH2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS02300 ^@ http://purl.uniprot.org/uniprot/S0ANE8 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS00025 ^@ http://purl.uniprot.org/uniprot/S0APJ8 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/333146:FACI_RS03725 ^@ http://purl.uniprot.org/uniprot/S0ARH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS08165 ^@ http://purl.uniprot.org/uniprot/S0ATT1 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/333146:FACI_RS09445 ^@ http://purl.uniprot.org/uniprot/S0ARP4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS00050 ^@ http://purl.uniprot.org/uniprot/S0APK4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/333146:FACI_RS00680 ^@ http://purl.uniprot.org/uniprot/S0AM82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/333146:FACI_RS05435 ^@ http://purl.uniprot.org/uniprot/S0ASK4 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/333146:FACI_RS00570 ^@ http://purl.uniprot.org/uniprot/S0AL56 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 2 family.|||Catalyzes the irreversible beta-carboxylation of phosphoenolpyruvate (PEP) to form oxaloacetate (OAA), a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/333146:FACI_RS03390 ^@ http://purl.uniprot.org/uniprot/S0AN25 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/333146:FACI_RS01490 ^@ http://purl.uniprot.org/uniprot/S0AMT8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate. http://togogenome.org/gene/333146:FACI_RS02255 ^@ http://purl.uniprot.org/uniprot/S0AQT1 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/333146:FACI_RS04235 ^@ http://purl.uniprot.org/uniprot/S0ANK6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS04620 ^@ http://purl.uniprot.org/uniprot/S0APT9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/333146:FACI_RS02405 ^@ http://purl.uniprot.org/uniprot/S0AMF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS08540 ^@ http://purl.uniprot.org/uniprot/S0ATW5 ^@ Similarity ^@ Belongs to the prokaryotic pantothenate kinase family. http://togogenome.org/gene/333146:FACI_RS08490 ^@ http://purl.uniprot.org/uniprot/S0ATW0 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/333146:FACI_RS04360 ^@ http://purl.uniprot.org/uniprot/S0ANM7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS04420 ^@ http://purl.uniprot.org/uniprot/S0ARY9 ^@ Caution|||Function|||Similarity ^@ Belongs to the TBP family.|||General factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Binds specifically to the TATA box promoter element which lies close to the position of transcription initiation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS05915 ^@ http://purl.uniprot.org/uniprot/S0APH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/333146:FACI_RS00775 ^@ http://purl.uniprot.org/uniprot/S0AQ00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS09140 ^@ http://purl.uniprot.org/uniprot/S0AS64 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/333146:FACI_RS07350 ^@ http://purl.uniprot.org/uniprot/S0ATK3 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS01575 ^@ http://purl.uniprot.org/uniprot/S0ALY6 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 5 (UDGb) family. http://togogenome.org/gene/333146:FACI_RS06390 ^@ http://purl.uniprot.org/uniprot/S0AR63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/333146:FACI_RS05670 ^@ http://purl.uniprot.org/uniprot/S0AQS3 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/333146:FACI_RS08525 ^@ http://purl.uniprot.org/uniprot/S0ASC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS07430 ^@ http://purl.uniprot.org/uniprot/S0AR83 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/333146:FACI_RS05765 ^@ http://purl.uniprot.org/uniprot/S0AQB7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 2 subfamily.|||Could be responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/333146:FACI_RS05035 ^@ http://purl.uniprot.org/uniprot/S0APY9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/333146:FACI_RS03070 ^@ http://purl.uniprot.org/uniprot/S0AR77 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/333146:FACI_RS02000 ^@ http://purl.uniprot.org/uniprot/S0AQD7 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/333146:FACI_RS06230 ^@ http://purl.uniprot.org/uniprot/S0AT64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/333146:FACI_RS05755 ^@ http://purl.uniprot.org/uniprot/S0ASY2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05495 ^@ http://purl.uniprot.org/uniprot/S0AQ66 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/333146:FACI_RS03120 ^@ http://purl.uniprot.org/uniprot/S0AMV6 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/333146:FACI_RS09500 ^@ http://purl.uniprot.org/uniprot/S0AU42 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FdhD family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Required for formate dehydrogenase (FDH) activity. Acts as a sulfur carrier protein that transfers sulfur from IscS to the molybdenum cofactor prior to its insertion into FDH. http://togogenome.org/gene/333146:FACI_RS07990 ^@ http://purl.uniprot.org/uniprot/S0ATT3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS02095 ^@ http://purl.uniprot.org/uniprot/S0AQF7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS08210 ^@ http://purl.uniprot.org/uniprot/S0ATV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/333146:FACI_RS04440 ^@ http://purl.uniprot.org/uniprot/S0AS85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Heterodimer of a large subunit and a small subunit.|||Possesses two activities: a DNA synthesis (polymerase) and an exonucleolytic activity that degrades single-stranded DNA in the 3' to 5' direction. Has a template-primer preference which is characteristic of a replicative DNA polymerase. http://togogenome.org/gene/333146:FACI_RS03820 ^@ http://purl.uniprot.org/uniprot/S0ANA2 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS01525 ^@ http://purl.uniprot.org/uniprot/S0ALX9 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family. http://togogenome.org/gene/333146:FACI_RS02490 ^@ http://purl.uniprot.org/uniprot/S0ANI9 ^@ Caution|||Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS02915 ^@ http://purl.uniprot.org/uniprot/S0ANT8 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/333146:FACI_RS05990 ^@ http://purl.uniprot.org/uniprot/S0AQY6 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/333146:FACI_RS08395 ^@ http://purl.uniprot.org/uniprot/S0AS93 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S41B family.|||Cytoplasm|||Degrades oligopeptides. http://togogenome.org/gene/333146:FACI_RS05850 ^@ http://purl.uniprot.org/uniprot/S0APG2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/333146:FACI_RS02050 ^@ http://purl.uniprot.org/uniprot/S0AQQ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS08835 ^@ http://purl.uniprot.org/uniprot/S0ATZ6 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/333146:FACI_RS04660 ^@ http://purl.uniprot.org/uniprot/S0ASC3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06655 ^@ http://purl.uniprot.org/uniprot/S0ATE2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/333146:FACI_RS05760 ^@ http://purl.uniprot.org/uniprot/S0AST1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05040 ^@ http://purl.uniprot.org/uniprot/S0AQE3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteropolymeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05260 ^@ http://purl.uniprot.org/uniprot/S0AQ27 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS06250 ^@ http://purl.uniprot.org/uniprot/S0APP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/333146:FACI_RS01105 ^@ http://purl.uniprot.org/uniprot/S0APT3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/333146:FACI_RS01255 ^@ http://purl.uniprot.org/uniprot/S0AQC2 ^@ Cofactor|||Similarity ^@ Belongs to the ELP3 family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/333146:FACI_RS04060 ^@ http://purl.uniprot.org/uniprot/S0ANH7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS05725 ^@ http://purl.uniprot.org/uniprot/S0APD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/333146:FACI_RS05640 ^@ http://purl.uniprot.org/uniprot/S0AQ96 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/333146:FACI_RS08080 ^@ http://purl.uniprot.org/uniprot/S0AQV5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/333146:FACI_RS08035 ^@ http://purl.uniprot.org/uniprot/S0ATT8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/333146:FACI_RS03580 ^@ http://purl.uniprot.org/uniprot/S0ARE5 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/333146:FACI_RS09425 ^@ http://purl.uniprot.org/uniprot/S0AU45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/333146:FACI_RS02555 ^@ http://purl.uniprot.org/uniprot/S0AQQ6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/333146:FACI_RS08670 ^@ http://purl.uniprot.org/uniprot/S0ARV9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/333146:FACI_RS09260 ^@ http://purl.uniprot.org/uniprot/S0AU30 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS03745 ^@ http://purl.uniprot.org/uniprot/S0AN87 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/333146:FACI_RS03055 ^@ http://purl.uniprot.org/uniprot/S0APA5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/333146:FACI_RS06865 ^@ http://purl.uniprot.org/uniprot/S0AQZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/333146:FACI_RS04695 ^@ http://purl.uniprot.org/uniprot/S0AS30 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/333146:FACI_RS04570 ^@ http://purl.uniprot.org/uniprot/S0AS08 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/333146:FACI_RS07775 ^@ http://purl.uniprot.org/uniprot/S0ATQ1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS07010 ^@ http://purl.uniprot.org/uniprot/S0ARH6 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/333146:FACI_RS08160 ^@ http://purl.uniprot.org/uniprot/S0ATU6 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/333146:FACI_RS04675 ^@ http://purl.uniprot.org/uniprot/S0APU3 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/333146:FACI_RS01020 ^@ http://purl.uniprot.org/uniprot/S0AN58 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/333146:FACI_RS08875 ^@ http://purl.uniprot.org/uniprot/S0ASK8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GmhB family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/333146:FACI_RS02090 ^@ http://purl.uniprot.org/uniprot/S0AM91 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/333146:FACI_RS08155 ^@ http://purl.uniprot.org/uniprot/S0AQX4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/333146:FACI_RS03195 ^@ http://purl.uniprot.org/uniprot/S0AMX6 ^@ Similarity ^@ Belongs to the ETF alpha-subunit/FixB family. http://togogenome.org/gene/333146:FACI_RS00815 ^@ http://purl.uniprot.org/uniprot/S0APM0 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/333146:FACI_RS06125 ^@ http://purl.uniprot.org/uniprot/S0APL2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/333146:FACI_RS06605 ^@ http://purl.uniprot.org/uniprot/S0ATD5 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/333146:FACI_RS00555 ^@ http://purl.uniprot.org/uniprot/S0APV3 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/333146:FACI_RS04780 ^@ http://purl.uniprot.org/uniprot/S0AQA6 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Binds 1 zinc ion.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/333146:FACI_RS06775 ^@ http://purl.uniprot.org/uniprot/S0AQ03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS01310 ^@ http://purl.uniprot.org/uniprot/S0AQD4 ^@ Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/333146:FACI_RS02115 ^@ http://purl.uniprot.org/uniprot/S0AM98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS03520 ^@ http://purl.uniprot.org/uniprot/S0AN48 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/333146:FACI_RS01440 ^@ http://purl.uniprot.org/uniprot/S0AMR0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07790 ^@ http://purl.uniprot.org/uniprot/S0AQM6 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS06910 ^@ http://purl.uniprot.org/uniprot/S0AR00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Belongs to the prefoldin subunit alpha family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/333146:FACI_RS09835 ^@ http://purl.uniprot.org/uniprot/S0AQ51 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/333146:FACI_RS08660 ^@ http://purl.uniprot.org/uniprot/S0ATY5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/333146:FACI_RS02720 ^@ http://purl.uniprot.org/uniprot/S0AQT4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/333146:FACI_RS01015 ^@ http://purl.uniprot.org/uniprot/S0AMF1 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/333146:FACI_RS07830 ^@ http://purl.uniprot.org/uniprot/S0ARF1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/333146:FACI_RS03370 ^@ http://purl.uniprot.org/uniprot/S0AR94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS01320 ^@ http://purl.uniprot.org/uniprot/S0ANB9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/333146:FACI_RS07945 ^@ http://purl.uniprot.org/uniprot/S0ATR5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Homodimer.|||Resistance to Hg(2+) in bacteria appears to be governed by a specialized system which includes mercuric reductase. MerA protein is responsible for volatilizing mercury as Hg(0). http://togogenome.org/gene/333146:FACI_RS05965 ^@ http://purl.uniprot.org/uniprot/S0AQY2 ^@ Cofactor|||Function|||Subunit ^@ Binds 2 [4Fe-4S] clusters. In this family the first cluster has a non-standard and varying [4Fe-4S] binding motif CX(2)CX(2)CX(4-5)CP.|||Catalyzes the ferredoxin-dependent oxidative decarboxylation of arylpyruvates.|||Heterodimer of the IorA and IorB subunits. http://togogenome.org/gene/333146:FACI_RS02830 ^@ http://purl.uniprot.org/uniprot/S0AMQ0 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. N(4) subfamily. http://togogenome.org/gene/333146:FACI_RS05635 ^@ http://purl.uniprot.org/uniprot/S0ASQ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS02045 ^@ http://purl.uniprot.org/uniprot/S0AM81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/333146:FACI_RS07635 ^@ http://purl.uniprot.org/uniprot/S0ATN6 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/333146:FACI_RS00760 ^@ http://purl.uniprot.org/uniprot/S0AN10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/333146:FACI_RS02485 ^@ http://purl.uniprot.org/uniprot/S0AQX1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/333146:FACI_RS07760 ^@ http://purl.uniprot.org/uniprot/S0ARV8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS08295 ^@ http://purl.uniprot.org/uniprot/S0AS67 ^@ Similarity ^@ Belongs to the SHMT family. http://togogenome.org/gene/333146:FACI_RS04875 ^@ http://purl.uniprot.org/uniprot/S0ASF6 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS03335 ^@ http://purl.uniprot.org/uniprot/S0APG7 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/333146:FACI_RS00575 ^@ http://purl.uniprot.org/uniprot/S0APH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/333146:FACI_RS04950 ^@ http://purl.uniprot.org/uniprot/S0ASH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/333146:FACI_RS02580 ^@ http://purl.uniprot.org/uniprot/S0AQR0 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/333146:FACI_RS05715 ^@ http://purl.uniprot.org/uniprot/S0AQA8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/333146:FACI_RS05870 ^@ http://purl.uniprot.org/uniprot/S0AQD8 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/333146:FACI_RS03755 ^@ http://purl.uniprot.org/uniprot/S0ARM7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS05775 ^@ http://purl.uniprot.org/uniprot/S0APE5 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/333146:FACI_RS02370 ^@ http://purl.uniprot.org/uniprot/S0ANG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05810 ^@ http://purl.uniprot.org/uniprot/S0ASU5 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/333146:FACI_RS05210 ^@ http://purl.uniprot.org/uniprot/S0ASE8 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/333146:FACI_RS07415 ^@ http://purl.uniprot.org/uniprot/S0AQF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS09370 ^@ http://purl.uniprot.org/uniprot/S0ASV0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family. http://togogenome.org/gene/333146:FACI_RS07835 ^@ http://purl.uniprot.org/uniprot/S0ARX2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/333146:FACI_RS03110 ^@ http://purl.uniprot.org/uniprot/S0ANX4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS01555 ^@ http://purl.uniprot.org/uniprot/S0AQ47 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/333146:FACI_RS02215 ^@ http://purl.uniprot.org/uniprot/S0ANU2 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/333146:FACI_RS07965 ^@ http://purl.uniprot.org/uniprot/S0ATT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/333146:FACI_RS02880 ^@ http://purl.uniprot.org/uniprot/S0AQY3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS01280 ^@ http://purl.uniprot.org/uniprot/S0APW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS00700 ^@ http://purl.uniprot.org/uniprot/S0APY2 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/333146:FACI_RS03515 ^@ http://purl.uniprot.org/uniprot/S0APK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Archaeal shikimate kinase subfamily.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS00835 ^@ http://purl.uniprot.org/uniprot/S0AN24 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS01470 ^@ http://purl.uniprot.org/uniprot/S0ANG2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer. http://togogenome.org/gene/333146:FACI_RS00085 ^@ http://purl.uniprot.org/uniprot/S0AP77 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/333146:FACI_RS01810 ^@ http://purl.uniprot.org/uniprot/S0AQM9 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/333146:FACI_RS02005 ^@ http://purl.uniprot.org/uniprot/S0AQQ1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Repair polymerase that plays a key role in base-excision repair. Has 5'-deoxyribose-5-phosphate lyase (dRP lyase) activity that removes the 5' sugar phosphate and also acts as a DNA polymerase that adds one nucleotide to the 3' end of the arising single-nucleotide gap. Conducts 'gap-filling' DNA synthesis in a stepwise distributive fashion rather than in a processive fashion as for other DNA polymerases. http://togogenome.org/gene/333146:FACI_RS06675 ^@ http://purl.uniprot.org/uniprot/S0APY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Degrades polypeptides processively.|||Belongs to the peptidase S16 family. Archaeal LonB subfamily.|||Cell membrane|||Homohexamer. Organized in a ring with a central cavity.|||Membrane http://togogenome.org/gene/333146:FACI_RS05320 ^@ http://purl.uniprot.org/uniprot/S0AP49 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/333146:FACI_RS00035 ^@ http://purl.uniprot.org/uniprot/S0AMK9 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/333146:FACI_RS03565 ^@ http://purl.uniprot.org/uniprot/S0AP73 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Probably involved in E site tRNA release (By similarity). Binds directly to 23S rRNA.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/333146:FACI_RS09105 ^@ http://purl.uniprot.org/uniprot/S0AU19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS08800 ^@ http://purl.uniprot.org/uniprot/S0ASJ0 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/333146:FACI_RS05090 ^@ http://purl.uniprot.org/uniprot/S0AQF3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/333146:FACI_RS05190 ^@ http://purl.uniprot.org/uniprot/S0AQ13 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS02260 ^@ http://purl.uniprot.org/uniprot/S0AND9 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/333146:FACI_RS01665 ^@ http://purl.uniprot.org/uniprot/S0AMX7 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/333146:FACI_RS05065 ^@ http://purl.uniprot.org/uniprot/S0AQE7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/333146:FACI_RS08590 ^@ http://purl.uniprot.org/uniprot/S0ATX1 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/333146:FACI_RS01530 ^@ http://purl.uniprot.org/uniprot/S0AQ40 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/333146:FACI_RS08130 ^@ http://purl.uniprot.org/uniprot/S0AQW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06915 ^@ http://purl.uniprot.org/uniprot/S0ARG1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/333146:FACI_RS03460 ^@ http://purl.uniprot.org/uniprot/S0AP50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/333146:FACI_RS04645 ^@ http://purl.uniprot.org/uniprot/S0APU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06000 ^@ http://purl.uniprot.org/uniprot/S0AT23 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07365 ^@ http://purl.uniprot.org/uniprot/S0AQE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/333146:FACI_RS05515 ^@ http://purl.uniprot.org/uniprot/S0ASM6 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily. http://togogenome.org/gene/333146:FACI_RS07170 ^@ http://purl.uniprot.org/uniprot/S0AR44 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/333146:FACI_RS07740 ^@ http://purl.uniprot.org/uniprot/S0AQL6 ^@ Function|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family. http://togogenome.org/gene/333146:FACI_RS05750 ^@ http://purl.uniprot.org/uniprot/S0APE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS00655 ^@ http://purl.uniprot.org/uniprot/S0AM79 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/333146:FACI_RS05700 ^@ http://purl.uniprot.org/uniprot/S0APC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; contacts the 5S rRNA and probably tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. May contact the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/333146:FACI_RS04750 ^@ http://purl.uniprot.org/uniprot/S0APV2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/333146:FACI_RS08215 ^@ http://purl.uniprot.org/uniprot/S0ATT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06305 ^@ http://purl.uniprot.org/uniprot/S0AT76 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/333146:FACI_RS06810 ^@ http://purl.uniprot.org/uniprot/S0ATD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS04385 ^@ http://purl.uniprot.org/uniprot/S0ANN0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/333146:FACI_RS07605 ^@ http://purl.uniprot.org/uniprot/S0ATP8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS03475 ^@ http://purl.uniprot.org/uniprot/S0ARC6 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/333146:FACI_RS08150 ^@ http://purl.uniprot.org/uniprot/S0AS32 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/333146:FACI_RS04885 ^@ http://purl.uniprot.org/uniprot/S0APX2 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/333146:FACI_RS04730 ^@ http://purl.uniprot.org/uniprot/S0AQA0 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/333146:FACI_RS07860 ^@ http://purl.uniprot.org/uniprot/S0ARX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS05060 ^@ http://purl.uniprot.org/uniprot/S0APZ3 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/333146:FACI_RS08200 ^@ http://purl.uniprot.org/uniprot/S0AS43 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS03165 ^@ http://purl.uniprot.org/uniprot/S0ANY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/333146:FACI_RS06650 ^@ http://purl.uniprot.org/uniprot/S0APY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/333146:FACI_RS05720 ^@ http://purl.uniprot.org/uniprot/S0AQT0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS00430 ^@ http://purl.uniprot.org/uniprot/S0APS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07615 ^@ http://purl.uniprot.org/uniprot/S0ARB2 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS04285 ^@ http://purl.uniprot.org/uniprot/S0ANL5 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS04005 ^@ http://purl.uniprot.org/uniprot/S0ARS9 ^@ Caution|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/333146:FACI_RS05250 ^@ http://purl.uniprot.org/uniprot/S0AP34 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobD/CbiB family.|||Cell membrane|||Converts cobyric acid to cobinamide by the addition of aminopropanol on the F carboxylic group.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/333146:FACI_RS09120 ^@ http://purl.uniprot.org/uniprot/S0ASQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07765 ^@ http://purl.uniprot.org/uniprot/S0AQM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS07020 ^@ http://purl.uniprot.org/uniprot/S0ATI4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/333146:FACI_RS05665 ^@ http://purl.uniprot.org/uniprot/S0AQ99 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/333146:FACI_RS02010 ^@ http://purl.uniprot.org/uniprot/S0AN88 ^@ Similarity ^@ Belongs to the peptidase S45 family. http://togogenome.org/gene/333146:FACI_RS02715 ^@ http://purl.uniprot.org/uniprot/S0AMN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS04835 ^@ http://purl.uniprot.org/uniprot/S0APW2 ^@ Similarity ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/333146:FACI_RS03535 ^@ http://purl.uniprot.org/uniprot/S0ARI2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/333146:FACI_RS05230 ^@ http://purl.uniprot.org/uniprot/S0ASL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/333146:FACI_RS07655 ^@ http://purl.uniprot.org/uniprot/S0ATQ3 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS00285 ^@ http://purl.uniprot.org/uniprot/S0APB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS04115 ^@ http://purl.uniprot.org/uniprot/S0ARU6 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/333146:FACI_RS01300 ^@ http://purl.uniprot.org/uniprot/S0ALQ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/333146:FACI_RS05995 ^@ http://purl.uniprot.org/uniprot/S0API3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/333146:FACI_RS09190 ^@ http://purl.uniprot.org/uniprot/S0ASR8 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/333146:FACI_RS04380 ^@ http://purl.uniprot.org/uniprot/S0AQ44 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/333146:FACI_RS04840 ^@ http://purl.uniprot.org/uniprot/S0AQB5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS07055 ^@ http://purl.uniprot.org/uniprot/S0AR25 ^@ Similarity ^@ Belongs to the HsdR family. http://togogenome.org/gene/333146:FACI_RS01855 ^@ http://purl.uniprot.org/uniprot/S0AQA3 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/333146:FACI_RS00895 ^@ http://purl.uniprot.org/uniprot/S0ALD9 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/333146:FACI_RS01930 ^@ http://purl.uniprot.org/uniprot/S0ANQ0 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/333146:FACI_RS05385 ^@ http://purl.uniprot.org/uniprot/S0ASJ2 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS05085 ^@ http://purl.uniprot.org/uniprot/S0APZ8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/333146:FACI_RS08940 ^@ http://purl.uniprot.org/uniprot/S0AS34 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/333146:FACI_RS04735 ^@ http://purl.uniprot.org/uniprot/S0ANU8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/333146:FACI_RS07245 ^@ http://purl.uniprot.org/uniprot/S0ATK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/333146:FACI_RS09840 ^@ http://purl.uniprot.org/uniprot/S0AR51 ^@ Similarity ^@ Belongs to the ice-binding protein family. http://togogenome.org/gene/333146:FACI_RS06460 ^@ http://purl.uniprot.org/uniprot/S0AQS9 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/333146:FACI_RS07340 ^@ http://purl.uniprot.org/uniprot/S0ARN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS06830 ^@ http://purl.uniprot.org/uniprot/S0ATG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS06410 ^@ http://purl.uniprot.org/uniprot/S0AQQ5 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/333146:FACI_RS08205 ^@ http://purl.uniprot.org/uniprot/S0AQY8 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/333146:FACI_RS02085 ^@ http://purl.uniprot.org/uniprot/S0ANS4 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/333146:FACI_RS08465 ^@ http://purl.uniprot.org/uniprot/S0ATW9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06380 ^@ http://purl.uniprot.org/uniprot/S0AT67 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS03210 ^@ http://purl.uniprot.org/uniprot/S0ANZ6 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/333146:FACI_RS05205 ^@ http://purl.uniprot.org/uniprot/S0ASL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS06510 ^@ http://purl.uniprot.org/uniprot/S0AQU0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/333146:FACI_RS07670 ^@ http://purl.uniprot.org/uniprot/S0ART7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KdpA family.|||Cell membrane|||Part of the high-affinity ATP-driven potassium transport (or Kdp) system, which catalyzes the hydrolysis of ATP coupled with the electrogenic transport of potassium into the cytoplasm. This subunit binds the extracellular potassium ions and delivers the ions to the membrane domain of KdpB through an intramembrane tunnel.|||The system is composed of three essential subunits: KdpA, KdpB and KdpC. http://togogenome.org/gene/333146:FACI_RS06465 ^@ http://purl.uniprot.org/uniprot/S0AR88 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/333146:FACI_RS05220 ^@ http://purl.uniprot.org/uniprot/S0AQH5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Belongs to the ribosomal protein L31e family. http://togogenome.org/gene/333146:FACI_RS02160 ^@ http://purl.uniprot.org/uniprot/S0ANC0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06220 ^@ http://purl.uniprot.org/uniprot/S0AR30 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/333146:FACI_RS03610 ^@ http://purl.uniprot.org/uniprot/S0ARJ7 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS00525 ^@ http://purl.uniprot.org/uniprot/S0APG4 ^@ Function|||Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Glucose 1-dehydrogenase subfamily.|||Catalyzes the NAD(P)(+)-dependent oxidation of D-glucose to D-gluconate via gluconolactone. Can utilize both NAD(+) and NADP(+) as electron acceptor. Is involved in the degradation of glucose through a non-phosphorylative variant of the Entner-Doudoroff pathway. http://togogenome.org/gene/333146:FACI_RS07380 ^@ http://purl.uniprot.org/uniprot/S0AR74 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06995 ^@ http://purl.uniprot.org/uniprot/S0ATI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/333146:FACI_RS06130 ^@ http://purl.uniprot.org/uniprot/S0AT45 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/333146:FACI_RS05330 ^@ http://purl.uniprot.org/uniprot/S0ASI1 ^@ Similarity ^@ Belongs to the TrpC family. http://togogenome.org/gene/333146:FACI_RS04655 ^@ http://purl.uniprot.org/uniprot/S0ANT2 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/333146:FACI_RS00915 ^@ http://purl.uniprot.org/uniprot/S0AN41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05470 ^@ http://purl.uniprot.org/uniprot/S0AQ62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteropolymeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/333146:FACI_RS05615 ^@ http://purl.uniprot.org/uniprot/S0AQ89 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||In the C-terminal section; belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Membrane http://togogenome.org/gene/333146:FACI_RS06240 ^@ http://purl.uniprot.org/uniprot/S0AQK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/333146:FACI_RS02535 ^@ http://purl.uniprot.org/uniprot/S0AQX9 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/333146:FACI_RS03555 ^@ http://purl.uniprot.org/uniprot/S0ARE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/333146:FACI_RS05875 ^@ http://purl.uniprot.org/uniprot/S0AQW5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/333146:FACI_RS01600 ^@ http://purl.uniprot.org/uniprot/S0ALZ3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/333146:FACI_RS04700 ^@ http://purl.uniprot.org/uniprot/S0APU7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/333146:FACI_RS01120 ^@ http://purl.uniprot.org/uniprot/S0AN79 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06470 ^@ http://purl.uniprot.org/uniprot/S0APU9 ^@ Cofactor|||Similarity ^@ Belongs to the PdaD family.|||Binds 1 pyruvoyl group covalently per subunit. http://togogenome.org/gene/333146:FACI_RS08655 ^@ http://purl.uniprot.org/uniprot/S0ARA0 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/333146:FACI_RS04435 ^@ http://purl.uniprot.org/uniprot/S0ANN8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/333146:FACI_RS04290 ^@ http://purl.uniprot.org/uniprot/S0AS62 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/333146:FACI_RS02640 ^@ http://purl.uniprot.org/uniprot/S0AP19 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/333146:FACI_RS00710 ^@ http://purl.uniprot.org/uniprot/S0AMZ5 ^@ Similarity ^@ Belongs to the 4HPPD family. http://togogenome.org/gene/333146:FACI_RS03065 ^@ http://purl.uniprot.org/uniprot/S0AR18 ^@ Similarity ^@ Belongs to the arsA ATPase family. http://togogenome.org/gene/333146:FACI_RS08005 ^@ http://purl.uniprot.org/uniprot/S0AS03 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. http://togogenome.org/gene/333146:FACI_RS07310 ^@ http://purl.uniprot.org/uniprot/S0AR64 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS02865 ^@ http://purl.uniprot.org/uniprot/S0ANS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/333146:FACI_RS05365 ^@ http://purl.uniprot.org/uniprot/S0AQL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS02495 ^@ http://purl.uniprot.org/uniprot/S0ANZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal dihydroneopterin aldolase family.|||Catalyzes the conversion of 7,8-dihydroneopterin (H2Neo) to 6-hydroxymethyl-7,8-dihydropterin (6-HMD).|||Homotetramer. http://togogenome.org/gene/333146:FACI_RS02615 ^@ http://purl.uniprot.org/uniprot/S0ANL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS06395 ^@ http://purl.uniprot.org/uniprot/S0APS4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/333146:FACI_RS07685 ^@ http://purl.uniprot.org/uniprot/S0ARC5 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/333146:FACI_RS02705 ^@ http://purl.uniprot.org/uniprot/S0ANN6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/333146:FACI_RS05730 ^@ http://purl.uniprot.org/uniprot/S0ASX0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Part of the 30S ribosomal subunit. Contacts protein S4.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/333146:FACI_RS08075 ^@ http://purl.uniprot.org/uniprot/S0AS15 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/333146:FACI_RS05645 ^@ http://purl.uniprot.org/uniprot/S0AQR8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/333146:FACI_RS06580 ^@ http://purl.uniprot.org/uniprot/S0ATB0 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/333146:FACI_RS02610 ^@ http://purl.uniprot.org/uniprot/S0AQZ4 ^@ Similarity ^@ Belongs to the histidinol dehydrogenase family. http://togogenome.org/gene/333146:FACI_RS05155 ^@ http://purl.uniprot.org/uniprot/S0ASK3 ^@ Similarity ^@ Belongs to the UPF0147 family. http://togogenome.org/gene/333146:FACI_RS02290 ^@ http://purl.uniprot.org/uniprot/S0AQJ0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS06060 ^@ http://purl.uniprot.org/uniprot/S0AQH2 ^@ Function|||Similarity ^@ Belongs to the CRISPR-associated protein Cas6/Cse3/CasE family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/333146:FACI_RS05830 ^@ http://purl.uniprot.org/uniprot/S0ASZ1 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/333146:FACI_RS07730 ^@ http://purl.uniprot.org/uniprot/S0ARD4 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/333146:FACI_RS04100 ^@ http://purl.uniprot.org/uniprot/S0AQ08 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/333146:FACI_RS08025 ^@ http://purl.uniprot.org/uniprot/S0ARJ0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/333146:FACI_RS04625 ^@ http://purl.uniprot.org/uniprot/S0AQ84 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/333146:FACI_RS02595 ^@ http://purl.uniprot.org/uniprot/S0AP10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/333146:FACI_RS09025 ^@ http://purl.uniprot.org/uniprot/S0ASP8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/333146:FACI_RS00105 ^@ http://purl.uniprot.org/uniprot/S0AKW6 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/333146:FACI_RS00905 ^@ http://purl.uniprot.org/uniprot/S0AQ31 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/333146:FACI_RS00660 ^@ http://purl.uniprot.org/uniprot/S0AMY6 ^@ Similarity ^@ Belongs to the transcriptional regulator TrmB family.