http://togogenome.org/gene/36329:PF3D7_1361000 ^@ http://purl.uniprot.org/uniprot/Q8ID96 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/36329:PF3D7_0208000 ^@ http://purl.uniprot.org/uniprot/O96167 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_0316700 ^@ http://purl.uniprot.org/uniprot/O77388 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1135600 ^@ http://purl.uniprot.org/uniprot/Q8II07 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome http://togogenome.org/gene/36329:PF3D7_1130100 ^@ http://purl.uniprot.org/uniprot/Q8II62 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL38 family. http://togogenome.org/gene/36329:PF3D7_0608500 ^@ http://purl.uniprot.org/uniprot/C6KST3 ^@ Similarity ^@ Belongs to the peptidase T1A family. http://togogenome.org/gene/36329:PF3D7_0613700 ^@ http://purl.uniprot.org/uniprot/C6KSX9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/36329:PF3D7_0307300 ^@ http://purl.uniprot.org/uniprot/O97251 ^@ Similarity ^@ Belongs to the MAPRE family. http://togogenome.org/gene/36329:PF3D7_0619500 ^@ http://purl.uniprot.org/uniprot/C6KT35 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/36329:PF3D7_0516500 ^@ http://purl.uniprot.org/uniprot/C0H4E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1445500 ^@ http://purl.uniprot.org/uniprot/Q8IL18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the C1D family.|||Cytoplasm|||Monomer and homodimer.|||Nucleus|||Plays a role in the recruitment of the exosome to pre-rRNA to mediate the 3'-5' end processing of the 5.8S rRNA.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1304000 ^@ http://purl.uniprot.org/uniprot/C0H598 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0409600 ^@ http://purl.uniprot.org/uniprot/Q9U0J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0104400 ^@ http://purl.uniprot.org/uniprot/Q8I295 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspH family.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.|||Interacts with Fd/ferredoxin.|||Was shown to bind 1 [3Fe-4S] cluster (PubMed:24188825). However, it initially contains a [4Fe-4S] cluster which easily degrades into a [3Fe-4S] form in the presence of oxygen (Probable).|||apicoplast http://togogenome.org/gene/36329:PF3D7_0603300 ^@ http://purl.uniprot.org/uniprot/Q08210 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Mitochondrion inner membrane|||Monomer. http://togogenome.org/gene/36329:PF3D7_0527200 ^@ http://purl.uniprot.org/uniprot/Q8I3J3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/36329:PF3D7_0624000 ^@ http://purl.uniprot.org/uniprot/C6KT76 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/36329:PF3D7_0627700 ^@ http://purl.uniprot.org/uniprot/C6KTB3 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_0528700 ^@ http://purl.uniprot.org/uniprot/Q8I3I0 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_0914700 ^@ http://purl.uniprot.org/uniprot/Q8I305 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1408000 ^@ http://purl.uniprot.org/uniprot/Q8I6V3 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987).|||During the asexual blood stage, participates in initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation (PubMed:29943906). May cleave preferentially denatured hemoglobin that has been cleaved by PMI (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).|||Expressed during the asexual blood stage including in trophozoites (at protein level).|||Inhibited by pepstatin A (PubMed:29943906). Inhibited by KNI derived compounds (KNI-10742, 10743, 10395, 10333, and 10343) (PubMed:29943906).|||Membrane|||Not N-glycosylated.|||Proteolytically cleaved into the soluble active mature form in the digestive vacuole by cysteine protease falcipains; the process begins at the early ring stage (PubMed:14709539, PubMed:18308731). Proteolysis requires an acidic environment (PubMed:14709539, PubMed:18308731). In absence of falcipains, autoprocessing may serve as an alternate activation system (PubMed:18308731).|||Slight decrease in proliferation and slight increase in doubling time during the asexual blood stage.|||Vacuole lumen|||Vacuole membrane http://togogenome.org/gene/36329:PF3D7_0617800 ^@ http://purl.uniprot.org/uniprot/C6KT18 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_0923500 ^@ http://purl.uniprot.org/uniprot/Q8I2S1 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/36329:PF3D7_0933500 ^@ http://purl.uniprot.org/uniprot/Q8I2I3 ^@ Similarity ^@ Belongs to the TUBGCP family. http://togogenome.org/gene/36329:PF3D7_0630900 ^@ http://purl.uniprot.org/uniprot/C6KTE4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX18/HAS1 subfamily. http://togogenome.org/gene/36329:PF3D7_0516400 ^@ http://purl.uniprot.org/uniprot/Q8I3U4 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/36329:PF3D7_1034900 ^@ http://purl.uniprot.org/uniprot/Q8IJ60 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1420400 ^@ http://purl.uniprot.org/uniprot/Q8ILP6 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0908000 ^@ http://purl.uniprot.org/uniprot/C0H524 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/36329:PF3D7_0413600 ^@ http://purl.uniprot.org/uniprot/Q8I1V1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_0927300 ^@ http://purl.uniprot.org/uniprot/Q8I2N6 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/36329:PF3D7_1323400 ^@ http://purl.uniprot.org/uniprot/Q8IE82 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/36329:PF3D7_1442100 ^@ http://purl.uniprot.org/uniprot/C6S3I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the replication factor A protein 3 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0209600 ^@ http://purl.uniprot.org/uniprot/O96181 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1469000 ^@ http://purl.uniprot.org/uniprot/Q8IKE7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/36329:PF3D7_0714500 ^@ http://purl.uniprot.org/uniprot/Q8IBV2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1123900 ^@ http://purl.uniprot.org/uniprot/Q8IIC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0806400 ^@ http://purl.uniprot.org/uniprot/Q8IAQ4 ^@ Similarity ^@ Belongs to the glycosyltransferase 28 family. http://togogenome.org/gene/36329:PF3D7_1364500 ^@ http://purl.uniprot.org/uniprot/Q8ID62 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1120100 ^@ http://purl.uniprot.org/uniprot/Q8IIG6 ^@ Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily. http://togogenome.org/gene/36329:PF3D7_1327700 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8T6 ^@ Similarity ^@ Belongs to the RENT3 family. http://togogenome.org/gene/36329:PF3D7_0820000 ^@ http://purl.uniprot.org/uniprot/C0H4W3 ^@ Biotechnology|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNF2/RAD54 helicase family. SWR1 subfamily.|||Catalytic component of a chromatin remodeling complex.|||Component of a chromatin-remodeling complex.|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0617000 ^@ http://purl.uniprot.org/uniprot/C6KT11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom40 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/36329:PF3D7_1426900 ^@ http://purl.uniprot.org/uniprot/Q8ILJ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRH/QCR6 family.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1357900 ^@ http://purl.uniprot.org/uniprot/Q8IDC6 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/36329:PF3D7_1223800 ^@ http://purl.uniprot.org/uniprot/Q8I5H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0917100 ^@ http://purl.uniprot.org/uniprot/Q8I2Y2 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/36329:PF3D7_0819500 ^@ http://purl.uniprot.org/uniprot/C0H4W0 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/36329:PF3D7_0909300 ^@ http://purl.uniprot.org/uniprot/Q8I359 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/36329:PF3D7_0920000 ^@ http://purl.uniprot.org/uniprot/C0H545 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0615100 ^@ http://purl.uniprot.org/uniprot/C6KSZ2 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. FabI subfamily. http://togogenome.org/gene/36329:PF3D7_1457200 ^@ http://purl.uniprot.org/uniprot/Q7KQL8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioredoxin family.|||Cytoplasm|||Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:11013257, PubMed:20673832). By modifying the redox status of targeted proteins, induces changes in their structure and activity (PubMed:19360125, PubMed:20673832). Reduces oxidized glutathione (GSSG), thereby acting as a backup for the glutathione redox system (PubMed:11013257). Reduces nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO) (PubMed:11013257). Also reduces oxidative stress by detoxifying hydrogen peroxide, tert-butyl hydroperoxide and cumene hydroperoxide (PubMed:14962358). Activates ornithine aminotransferase OAT by reducing a disulfide bond in the substrate binding loop, thereby enhancing the affinity of OAT for its substrates (PubMed:20673832). May reduce S-adenosyl-L-homocysteine hydrolase SAHH (PubMed:19360125).|||The disulfide bond between Cys-30 and Cys-33 acts as a redox-active center and is reduced by thioredoxin reductase TRXR. http://togogenome.org/gene/36329:PF3D7_0823300 ^@ http://purl.uniprot.org/uniprot/Q8IB67 ^@ Similarity ^@ Belongs to the acetyltransferase family. GCN5 subfamily. http://togogenome.org/gene/36329:PF3D7_1363400 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8W0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1323300 ^@ http://purl.uniprot.org/uniprot/Q8IE83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acetyltransferase family. NAA40 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1416100 ^@ http://purl.uniprot.org/uniprot/Q8ILT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. RHD3 subfamily.|||Endoplasmic reticulum membrane|||Probable GTP-binding protein involved in generating and maintaining the structure of the tubular endoplasmic reticulum network. http://togogenome.org/gene/36329:PF3D7_1206700 ^@ http://purl.uniprot.org/uniprot/Q8I5X8 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/36329:PF3D7_1210400 ^@ http://purl.uniprot.org/uniprot/Q8I5U5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0906500 ^@ http://purl.uniprot.org/uniprot/Q8I384 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||Similarity|||Subunit ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the hydrolysis of L-arginine into urea and L-ornithine, which is a precursor for polyamine biosynthesis (PubMed:15843155, PubMed:19456858, PubMed:20527960, PubMed:21728378). May play a role in parasite intra-hepatic development during the host liver stage (By similarity).|||Expressed during the asexual blood stage; expression is high in rings and young trophozoites, and low in mature trophozoites and schizonts.|||Feedback inhibition by product L-ornithine, (PubMed:15843155). Inhibited by 2(S)-amino-6-boronohexanoic acid (ABH); however, with less efficiency than human ARG1 (PubMed:20527960, PubMed:21728378).|||Homotrimer; oligomerization is dependent on Mn(2+) binding. http://togogenome.org/gene/36329:PF3D7_1243000 ^@ http://purl.uniprot.org/uniprot/Q8I4Z9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/36329:PF3D7_1243800 ^@ http://purl.uniprot.org/uniprot/Q8I4Z2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0217500 ^@ http://purl.uniprot.org/uniprot/P62344 ^@ Activity Regulation|||Caution|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by calcium (PubMed:29716996, PubMed:18768477, PubMed:23204525, PubMed:17123645, PubMed:32484216). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (Probable) (PubMed:23204525). This, in turn may facilitate the autophosphorylation of the activation loop at Thr-231, which leads to the kinase activation (PubMed:19307175). May be negatively regulated by PKA-mediated phosphorylation (PubMed:28680058). Inhibited by purfalcamine (PubMed:23204525, PubMed:29716996).|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.|||Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:18768477, PubMed:19307175, PubMed:28680058, PubMed:29716996). By phosphorylating various proteins, required for microneme secretion and thus merozoite egress from and invasion of host erythrocytes (PubMed:23204525, PubMed:28680058, PubMed:29716996). During gametogenesis, essential for the development of both male and female gametes (By similarity). Phosphorylates SERA5 p50 which enhances SERA5 p50 protease activity; however, SERA5 p50 protease activity has been shown in other studies to be controversial (PubMed:29716996). Probably by phosphorylating SERA5 p50, plays a role in merozoite egress from host erythrocytes (PubMed:29716996). Probably prior or during merozoite invasion of host erythrocytes, phosphorylates rhoptry protein RhopH3 which is required for RhopH3 localization to rhoptries and for its secretion (PubMed:33024030). Probably in late schizonts, phosphorylates myosin A tail domain-interacting protein MTIP and glideosome-associated protein 45 GAP45, both of which are components of the motor complex that generates the force required by the parasite to invade host cells (PubMed:18768477, PubMed:28680058, PubMed:22539638). In late schizonts, phosphorylates inner membrane complex protein IMC1g (PubMed:28680058). In late schizonts, phosphorylates PKA regulatory subunit PKAr in a calcium-dependent manner, which may contribute to the dissociation of regulatory PKAr and catalytic PKAc subunits and promote the activation of PKAc (PubMed:28680058). May phosphorylate raf kinase inhibitory protein RKIP which in turn may regulate CDPK1 catalytic activity (PubMed:17123645). May phosphorylate proteins of the host erythrocyte membranes (By similarity).|||Cell membrane|||Conditional knockdown at the ring stage produces the development of mature schizonts and the subsequent release of merozoites from the host erythrocytes; however, the invasion of new erythrocytes by these merozoites is severely reduced due to a severe defect in adhesion to the erythrocyte membrane (PubMed:28680058). In merozoites, release of host glycophorin A/GYPA ligand EBA-175 from micronemes is impaired but not AMA1 (PubMed:28680058). In late schizont, phosphorylation of several proteins including GAP45, IMC1g and PKAr is reduced (PubMed:28680058). Reduced PKA activity (PubMed:28680058). Rhoptry protein RhopH3 phosphorylation and secretion are reduced in merozoites (PubMed:33024030).|||Cytoplasm|||Expressed during parasite asexual blood stages, specifically at the ring and schizont stages, in free merozoites and to a lesser extent in trophozoites (at protein level).|||Host cell membrane|||Membrane|||Monomer (PubMed:26149123). Forms a high molecular weight (250 and 400 kDa) complex (PubMed:26149123). Forms a complex composed of CDPK1, PKA regulatory subunit PKAr and 14-3-3I; the complex is formed in merozoites in response to low extracellular level of K(+) and may play a role in microneme secretion (PubMed:32817103). Interacts (when phosphorylated) with 14-3-3I in a Ca(2+)-independent manner; the interaction does not regulate CDPK1 catalytic activity but is required for merozoite invasion of host erythrocytes (PubMed:32484216, PubMed:32817103). Interacts with PKA regulatory subunit PKAr; in a Ca(2+)-dependent manner (PubMed:28680058, PubMed:32817103). Interacts with SERA5 p50 in the late schizont stage (PubMed:29716996). Interacts with inner membrane complex protein IMC1g in late schizonts (PubMed:28680058). Interacts with rhoptry protein RhopH3 in merozoites (PubMed:33024030).|||Myristoylated (PubMed:15491359). Myristoylation, palmitoylation and the basic cluster motif are required for the localization to the parasitophorous vacuole membrane (PubMed:15491359).|||Palmitoylated (Probable) (PubMed:32003970). Palmitoylation increases in merozoites in response to low level of extracellular K(+) in the host blood (PubMed:32003970). Myristoylation, palmitoylation and the basic cluster motif are required for the localization to the parasitophorous vacuole membrane (PubMed:15491359).|||Parasitophorous vacuole membrane|||Phosphorylation at Ser-64 occurs at late schizont stage and regulates CDPK1 protein-protein interaction (PubMed:26149123). Phosphorylated at Ser-28, Ser-34 and Ser-64 in merozoites in response to low extracellular level of K(+) (PubMed:32817103). Phosphorylation at Thr-231 may regulate CDPK1 kinase activity (PubMed:26149123). Phosphorylation increases in response to an increase in intracellular Ca(2+) levels (PubMed:32484216). Autophosphorylated in vitro (PubMed:17123645, PubMed:22539638, PubMed:23204525, PubMed:26149123, PubMed:32484216). Autophosphorylation does not affect membrane localization in vitro (PubMed:15491359).|||The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (PubMed:19307175). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (PubMed:19307175, PubMed:23204525).|||Unlike P.berghei CDPK1, appears to be involved in the asexual blood stage and in male gamete exflagellation prior host erythrocyte membrane rupture.|||flagellum http://togogenome.org/gene/36329:PF3D7_0819000 ^@ http://purl.uniprot.org/uniprot/Q8IB25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0413900 ^@ http://purl.uniprot.org/uniprot/Q8I1U8 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/36329:PF3D7_0210400 ^@ http://purl.uniprot.org/uniprot/C6S3B5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/36329:PF3D7_0505300 ^@ http://purl.uniprot.org/uniprot/Q8I449 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1475000 ^@ http://purl.uniprot.org/uniprot/Q8IK88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 31 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1015800 ^@ http://purl.uniprot.org/uniprot/Q8IJN8 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/36329:PF3D7_0927900 ^@ http://purl.uniprot.org/uniprot/Q8I2N0 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Endoplasmic reticulum membrane|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase. http://togogenome.org/gene/36329:PF3D7_1145700 ^@ http://purl.uniprot.org/uniprot/Q8IHR1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. http://togogenome.org/gene/36329:PF3D7_1247800 ^@ http://purl.uniprot.org/uniprot/Q8I0V1 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/36329:PF3D7_1108500 ^@ http://purl.uniprot.org/uniprot/Q8IIR8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/36329:PF3D7_1144200 ^@ http://purl.uniprot.org/uniprot/Q8IHS4 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0319000 ^@ http://purl.uniprot.org/uniprot/O77368 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0811100 ^@ http://purl.uniprot.org/uniprot/Q8IAU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1467900 ^@ http://purl.uniprot.org/uniprot/Q8IKF8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1110500 ^@ http://purl.uniprot.org/uniprot/Q8IIQ6 ^@ Function|||Similarity ^@ Belongs to the VPS35 family.|||Plays a role in vesicular protein sorting. http://togogenome.org/gene/36329:PF3D7_1209800 ^@ http://purl.uniprot.org/uniprot/Q8I5V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP11 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1346200 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8D5 ^@ Similarity ^@ Belongs to the MOG1 family. http://togogenome.org/gene/36329:PF3D7_1030000 ^@ http://purl.uniprot.org/uniprot/Q8IJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1358500 ^@ http://purl.uniprot.org/uniprot/Q8IDC0 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/36329:PF3D7_0405600 ^@ http://purl.uniprot.org/uniprot/Q8I1X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1354500 ^@ http://purl.uniprot.org/uniprot/Q8IDF6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Parasitic protozoa lack the de novo purine biosynthesis pathway and rely exclusively on the salvage pathway for their purine nucleotide requirements.|||Plays an important role in the salvage pathway for purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP (By similarity). http://togogenome.org/gene/36329:PF3D7_0507500 ^@ http://purl.uniprot.org/uniprot/Q8I0V0 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S8 family.|||Binds 3 Ca(2+) ions per subunit.|||Blood stage parasites are not viable (PubMed:18083098, PubMed:29459732). Initial schizont development is normal but merozoite egress is abolished due to a failure to rupture the parasitophorous vacuole membrane (PubMed:29459732).|||Expressed during the parasite blood stage, specifically in schizonts (at protein level).|||Heterodimer between p54 form and propeptide p31; the interaction inhibits p54 catalytic activity.|||Parasitophorous vacuole lumen|||Secreted|||Serine protease which plays an essential role in merozoite invasion of and egress from host erythrocytes by processing and activating various merozoite surface and parasitophorous vacuole proteins (PubMed:18083098, PubMed:19214190, PubMed:21220481, PubMed:29459732). Mediates the proteolytic maturation of serine proteases SERA4, SERA5 and SERA6 just prior to merozoite egress (PubMed:18083098, PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves merozoite surface proteins MSP1, MSP6 and MSP7, which form the MSP1/6/7 complex, and thereby may prime the parasite cell surface for invasion of fresh erythrocytes (PubMed:19214190, PubMed:29459732). Prior to merozoite egress, cleaves MSRP2 converting it to MSRP2 p25 form, and RAP1 converting it to RAP1 p67 form (PubMed:21220481).|||The disulfide bond between Cys-521 and Cys-534 acts as a redox-sensitive disulfide switch. The oxidized form is required for catalytic activity.|||The propeptide (p31) is cleaved, probably by autocatalysis, during the transport to or in the Golgi apparatus, and remains non-covalently associated with the p54 form as an inhibitor. p54 is further cleaved into the p45 form (By similarity). This cleavage is likely occurring in the exoneme prior to egress and is mediated by PMX/plasmepsin X (PubMed:32109369).|||The relevance of the N-glycosylation is not clear. In an insect expression system, SUB1 glycosylation appears to affect its processing into the active mature form suggesting that SUB1 may not be N-glycosylated in parasites.|||p54 and probably p47 forms are inhibited by the non-covalent interaction with the cleaved propeptide (PubMed:19214190). Inhibited by subtilisin propeptide-like protein SUB1-ProM (PubMed:31942933). Inhibited by small molecule MRT12113 (PubMed:18083098). http://togogenome.org/gene/36329:PF3D7_1129000 ^@ http://purl.uniprot.org/uniprot/Q8II73 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/36329:PF3D7_1027800 ^@ http://purl.uniprot.org/uniprot/Q8IJC6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/36329:PF3D7_0729400 ^@ http://purl.uniprot.org/uniprot/Q8IBG5 ^@ Similarity ^@ Belongs to the BRX1 family. http://togogenome.org/gene/36329:PF3D7_0802000 ^@ http://purl.uniprot.org/uniprot/Q8IAM0 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/36329:PF3D7_1315900 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8Q1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/36329:PF3D7_0603000 ^@ http://purl.uniprot.org/uniprot/C6KSN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SDE2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0603200 ^@ http://purl.uniprot.org/uniprot/C6KSN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0715900 ^@ http://purl.uniprot.org/uniprot/Q8IBU1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1358100 ^@ http://purl.uniprot.org/uniprot/A0A5K1K911 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/36329:PF3D7_0621200 ^@ http://purl.uniprot.org/uniprot/C6KT50 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by Pdx2. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||Cytoplasm|||Homohexamer and homododecamer. In the presence of Pdx2, forms a dodecamer of heterodimers. http://togogenome.org/gene/36329:PF3D7_0608700 ^@ http://purl.uniprot.org/uniprot/C6KST5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0320700 ^@ http://purl.uniprot.org/uniprot/Q9NFA0 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SPCS2 family.|||Causes a severe growth defect in host erythrocytes (PubMed:30127496). Export of protein containing a PEXEL motif, including PIESP2, PTP3 and PTP2 is severely reduced at the ring and trophozoite stages (PubMed:30127496). Similarly, export of RESA is reduced at the schizont stage (PubMed:30127496).|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11/SPC21 and three accessory subunits SPC25, SPC3/SPC22, SPC1/SPC12 (PubMed:30127496). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). Within the complex, interacts with SEC11/SPC21 (PubMed:30127496). Component of a complex composed of SPC25 and PMV; the interaction is mediated via the transmembrane domains (PubMed:30127496). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the recognition and import of PEXEL motif-containing proteins into the ER for subsequent export (PubMed:30127496).|||Component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:30127496). Enhances the enzymatic activity of SPC and facilitates the interactions between different components of the translocation site (By similarity). Also, regulatory component of the CSP25-plasmepsin PMV complex which cleaves the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence of several proteins (PubMed:30127496).|||Endoplasmic reticulum membrane|||Expressed during the asexual blood stage; expression is low at the ring stage and then increases through the trophozoite and schizont stages (at protein level). http://togogenome.org/gene/36329:PF3D7_1435400 ^@ http://purl.uniprot.org/uniprot/Q8ILB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1456000 ^@ http://purl.uniprot.org/uniprot/Q8IKR9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0828200 ^@ http://purl.uniprot.org/uniprot/Q8IBB3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1225800 ^@ http://purl.uniprot.org/uniprot/Q8I5F9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/36329:PF3D7_0823900 ^@ http://purl.uniprot.org/uniprot/Q8IB73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1018200 ^@ http://purl.uniprot.org/uniprot/C6S3C9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_1344000 ^@ http://purl.uniprot.org/uniprot/C0H5G8 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/36329:PF3D7_0309200 ^@ http://purl.uniprot.org/uniprot/O77328 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/36329:PF3D7_1245300 ^@ http://purl.uniprot.org/uniprot/Q8I4X8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1118600 ^@ http://purl.uniprot.org/uniprot/Q8III2 ^@ Similarity ^@ Belongs to the MYST (SAS/MOZ) family. http://togogenome.org/gene/36329:PF3D7_1014200 ^@ http://purl.uniprot.org/uniprot/Q8IJQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAP2/GCS1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1403700 ^@ http://purl.uniprot.org/uniprot/Q8IM57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1338200 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8V8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/36329:PF3D7_1143200 ^@ http://purl.uniprot.org/uniprot/Q8IHT4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0722500 ^@ http://purl.uniprot.org/uniprot/Q8IBM8 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/36329:PF3D7_1474300 ^@ http://purl.uniprot.org/uniprot/Q8IK95 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0212800 ^@ http://purl.uniprot.org/uniprot/O96209 ^@ Similarity ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. http://togogenome.org/gene/36329:PF3D7_1333000 ^@ http://purl.uniprot.org/uniprot/Q8IDZ8 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/36329:PF3D7_0930500 ^@ http://purl.uniprot.org/uniprot/Q8I2K9 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/36329:PF3D7_0519400 ^@ http://purl.uniprot.org/uniprot/Q8I3R6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/36329:PF3D7_1407800 ^@ http://purl.uniprot.org/uniprot/Q8IM16 ^@ Activity Regulation|||Caution|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) (By similarity). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).|||Expressed during the asexual blood stage; expression begins in trophozoites and continues in schizonts (at protein level).|||Inhibited by KNI derived compounds KNI-10333 and to a lesser extent KNI-10743.|||It is unclear if PMIV is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.|||Membrane|||Proteolytically cleaved into the soluble active mature form by cysteine proteases in the digestive vacuole of trophozoites. Proteolysis requires an acidic environment. Autoprocessing or transprocessing by other plasmepsins such as PMII may serve as an alternate activation system.|||Quadruple knockout of PMI, PMII, PMIII and PMIV causes a decrease in proliferation, an impaired proliferation in an amino acid-limited medium, a reduced formation of haemozoin and an abnormal accumulation of endosomal vesicles inside the digestive vacuole.|||Vacuole lumen http://togogenome.org/gene/36329:PF3D7_1120500 ^@ http://purl.uniprot.org/uniprot/Q8IIG2 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/36329:PF3D7_0103100 ^@ http://purl.uniprot.org/uniprot/Q8I2A9 ^@ Similarity ^@ Belongs to the VPS51 family. http://togogenome.org/gene/36329:PF3D7_0306000 ^@ http://purl.uniprot.org/uniprot/Q9NLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UQCRQ/QCR8 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0907700 ^@ http://purl.uniprot.org/uniprot/Q8I374 ^@ Similarity ^@ Belongs to the PA28 family. http://togogenome.org/gene/36329:PF3D7_0309000 ^@ http://purl.uniprot.org/uniprot/O77334 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Binds 2 Zn(2+) ions.|||Cytoplasm|||Dual specificity protein phosphatase which dephosphorylates both phosphotyrosine and phosphoserine residues.|||Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expressed in gametocytes (at protein level) (PubMed:14698441).|||Interacts with PES.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1137500 ^@ http://purl.uniprot.org/uniprot/Q8IHZ0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/36329:PF3D7_1248100 ^@ http://purl.uniprot.org/uniprot/Q8I4V3 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METL family.|||S-adenosyl-L-methionine-dependent methyltransferase. http://togogenome.org/gene/36329:PF3D7_1201500 ^@ http://purl.uniprot.org/uniprot/Q8I630 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/36329:PF3D7_0610100 ^@ http://purl.uniprot.org/uniprot/C6KSU8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1323900 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8R6 ^@ Similarity ^@ Belongs to the BCP1 family. http://togogenome.org/gene/36329:PF3D7_1222000 ^@ http://purl.uniprot.org/uniprot/Q8I5J3 ^@ Cofactor|||Similarity ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/36329:PF3D7_1146700 ^@ http://purl.uniprot.org/uniprot/Q8IHQ1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0727000 ^@ http://purl.uniprot.org/uniprot/Q8IBI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS53 family.|||Endosome membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/36329:PF3D7_0829300 ^@ http://purl.uniprot.org/uniprot/C0H4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays role in pre-mRNA splicing as component of the U4/U6-U5 tri-snRNP complex that is involved in spliceosome assembly, and as component of the precatalytic spliceosome (spliceosome B complex). The heptameric LSM2-8 complex binds specifically to the 3'-terminal U-tract of U6 snRNA. http://togogenome.org/gene/36329:PF3D7_0817000 ^@ http://purl.uniprot.org/uniprot/C0H4V1 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/36329:PF3D7_0708900 ^@ http://purl.uniprot.org/uniprot/Q8IC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCO1/2 family.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1451400 ^@ http://purl.uniprot.org/uniprot/Q8IKW2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the sirtuin family. Class IV subfamily.|||Binds 1 zinc ion per subunit.|||Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis. Cooperates with Sir2A to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance. http://togogenome.org/gene/36329:PF3D7_0718400 ^@ http://purl.uniprot.org/uniprot/Q8IBR7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/36329:PF3D7_1429700 ^@ http://purl.uniprot.org/uniprot/Q8ILG7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/36329:PF3D7_1209000 ^@ http://purl.uniprot.org/uniprot/Q8I5V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pym family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1008000 ^@ http://purl.uniprot.org/uniprot/Q8IJW3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/36329:PF3D7_1326100 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8S8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1243200 ^@ http://purl.uniprot.org/uniprot/C6S3L2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/36329:PF3D7_0711400 ^@ http://purl.uniprot.org/uniprot/Q8IBX6 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/36329:PF3D7_1203300 ^@ http://purl.uniprot.org/uniprot/Q8I612 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/36329:PF3D7_1470400 ^@ http://purl.uniprot.org/uniprot/Q8IKD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1306600 ^@ http://purl.uniprot.org/uniprot/Q8IEP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/36329:PF3D7_1427500 ^@ http://purl.uniprot.org/uniprot/Q8ILI9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1354400 ^@ http://purl.uniprot.org/uniprot/Q8IDF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1032600 ^@ http://purl.uniprot.org/uniprot/Q8IJ81 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/36329:PF3D7_1408200 ^@ http://purl.uniprot.org/uniprot/Q8IM14 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0110600 ^@ http://purl.uniprot.org/uniprot/Q8I239 ^@ Activity Regulation|||Developmental Stage|||Function ^@ Catalytic activity is increase by myristoylated ARF1 (PubMed:19171150). Phosphatidic acid has no effect on catalytic activity (PubMed:19171150).|||Catalyzes the phosphorylation of phosphatidylinositol 4-phosphate (PtdIns(4)P/PI4P) to form phosphatidylinositol 4,5-bisphosphate (PtdIns(4,5)P2/PIP2), a lipid second messenger that regulates several cellular processes.|||Expressed during the asexual blood stage (at protein level) (PubMed:19171150). Expressed in gametocytes (at protein level) (PubMed:19171150). http://togogenome.org/gene/36329:PF3D7_0419800 ^@ http://purl.uniprot.org/uniprot/Q8I1P0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family. http://togogenome.org/gene/36329:PF3D7_0903900 ^@ http://purl.uniprot.org/uniprot/Q8I3B0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/36329:PF3D7_0506100 ^@ http://purl.uniprot.org/uniprot/Q8I441 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/36329:PF3D7_1013900 ^@ http://purl.uniprot.org/uniprot/Q8IJQ6 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/36329:PF3D7_0922200 ^@ http://purl.uniprot.org/uniprot/Q7K6A4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/36329:PF3D7_1228800 ^@ http://purl.uniprot.org/uniprot/Q8I5D0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1353500 ^@ http://purl.uniprot.org/uniprot/Q8IDG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB4 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1323100 ^@ http://purl.uniprot.org/uniprot/Q8IE85 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/36329:PF3D7_0621000 ^@ http://purl.uniprot.org/uniprot/C6KT48 ^@ Similarity ^@ Belongs to the sigma-70 factor family. http://togogenome.org/gene/36329:PF3D7_1357000 ^@ http://purl.uniprot.org/uniprot/Q8I0P6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/36329:PF3D7_0314000 ^@ http://purl.uniprot.org/uniprot/C0H473 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/36329:PF3D7_1223700 ^@ http://purl.uniprot.org/uniprot/Q8I5I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCC1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0829100 ^@ http://purl.uniprot.org/uniprot/C0H4Y8 ^@ Similarity ^@ Belongs to the CCDC124 family. http://togogenome.org/gene/36329:PF3D7_1115500 ^@ http://purl.uniprot.org/uniprot/Q8IIK9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1203600 ^@ http://purl.uniprot.org/uniprot/Q8I609 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0605600 ^@ http://purl.uniprot.org/uniprot/C6KSQ4 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/36329:PF3D7_1116600 ^@ http://purl.uniprot.org/uniprot/Q8IIK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1032500 ^@ http://purl.uniprot.org/uniprot/Q8IJ82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/36329:PF3D7_0517800 ^@ http://purl.uniprot.org/uniprot/C0H4E4 ^@ Biotechnology|||Developmental Stage|||Domain|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and free merozoites (at protein level).|||Human microRNA candidate miR-197 and to a lesser extent miR150 causes the down-regulation of apicortin and thus may be a possible candidate for nucleotide-based antimalarial treatment.|||Interacts with alpha-tubulin 1 and beta-tubulin; the interaction stabilizes microtubule assembly.|||Involved in the stabilization of microtubules (PubMed:33633135). Probably by controlling microtubules stabilization, plays a role in invasion, microneme secretion and parasite growth in host erythrocytes (PubMed:32493727).|||Tamoxifen used to treat breast cancer blocks the interaction between DCX/apicortin and, alpha-tubulin 1 and beta-tubulin resulting in microtubule destabilization.|||The doublecortin is involved in the binding to microtubules; however, it is not sufficient by itself and requires the partial p25alpha domain.|||The partial p25 alpha domain binds to microtubules.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0933600 ^@ http://purl.uniprot.org/uniprot/Q8I2I2 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/36329:PF3D7_1023100 ^@ http://purl.uniprot.org/uniprot/Q8IJH4 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/36329:PF3D7_1234300 ^@ http://purl.uniprot.org/uniprot/Q8I579 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase epsilon subunit B family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0714000 ^@ http://purl.uniprot.org/uniprot/Q8IBV7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_1333800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8U1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1405200 ^@ http://purl.uniprot.org/uniprot/Q8IM42 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/36329:PF3D7_0802100 ^@ http://purl.uniprot.org/uniprot/Q8IAM1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1029600 ^@ http://purl.uniprot.org/uniprot/Q8IJA9 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of adenosine to produce inosine (PubMed:19728741, PubMed:31002765). Unlike mammalian adenosine deaminases, also catalyzes the deamination of 5'-methylthioadenosine (MTA), a by-product of polyamine biosynthesis, to produce 5'-methylthioinosine (MTI) (PubMed:19728741, PubMed:31002765). Plays an essential role in the purine salvage pathway which allows the parasite to use host cell purines for the synthesis of nucleic acids (Probable).|||Inhibited by coformycin and methylthiocoformycin (MT-coformycin). http://togogenome.org/gene/36329:PF3D7_0103000 ^@ http://purl.uniprot.org/uniprot/B9ZSH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTA1 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1130400 ^@ http://purl.uniprot.org/uniprot/Q8II60 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_0520300 ^@ http://purl.uniprot.org/uniprot/Q8I3Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1128600 ^@ http://purl.uniprot.org/uniprot/Q8II77 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/36329:PF3D7_0802800 ^@ http://purl.uniprot.org/uniprot/Q8IAM8 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/36329:PF3D7_0620500 ^@ http://purl.uniprot.org/uniprot/C6KT45 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1250600 ^@ http://purl.uniprot.org/uniprot/Q8I4S8 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/36329:PF3D7_0524700 ^@ http://purl.uniprot.org/uniprot/Q8I3L8 ^@ Similarity ^@ Belongs to the Tom22 family. http://togogenome.org/gene/36329:PF3D7_0726800 ^@ http://purl.uniprot.org/uniprot/C0H4P5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DAD/OST2 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/36329:PF3D7_1463400 ^@ http://purl.uniprot.org/uniprot/Q8IKK2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0520700 ^@ http://purl.uniprot.org/uniprot/Q8I3Q4 ^@ Similarity ^@ Belongs to the CDC73 family. http://togogenome.org/gene/36329:PF3D7_0808100 ^@ http://purl.uniprot.org/uniprot/C0H4T0 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/36329:PF3D7_1311000 ^@ http://purl.uniprot.org/uniprot/Q8IEK7 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/36329:PF3D7_0932200 ^@ http://purl.uniprot.org/uniprot/Q8I2J4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the profilin family.|||Binds actin.|||Essential for the invasive blood stages of the parasite. Binds to proline rich sequences in various regulatory formin-like proteins and also to membrane phospholipids. Binds to actin and affects the structure of the cytoskeleton. Weakly sequesters actin monomers (By similarity).|||The actin binding residues are poorly conserved between Plasmodium and other organisms. The Plasmodium-specific profilin mini-domain may have a role in binding to membrane phospholipids.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0213700 ^@ http://purl.uniprot.org/uniprot/O96217 ^@ Similarity ^@ Belongs to the FAM136 family. http://togogenome.org/gene/36329:PF3D7_1360500 ^@ http://purl.uniprot.org/uniprot/Q8IDA0 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Basal guanylate activity of the recombinant guanylate cyclase domains 1 and 2 is not modulated by an increase in Ca(2+) levels or by the gametogenesis inducer xanthurenic acid.|||Binds 2 magnesium ions per subunit (By similarity). Is also active with manganese (in vitro) (Probable).|||Catalyzes the synthesis of the second messenger cGMP from GTP (PubMed:10747978, PubMed:11703675, PubMed:18452584). Regulates cGMP production in gametocytes; however, is dispensable for the initiation of gametogenesis (PubMed:18452584). Does not have adenylate cyclase activity (PubMed:10747978).|||During the blood stage, specifically expressed in gametocytes.|||In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||In the N-terminal section; belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane|||The N-terminus contains a P-type ATPase-like domain which is required for guanylate cyclase activity. http://togogenome.org/gene/36329:PF3D7_0622500 ^@ http://purl.uniprot.org/uniprot/C6KT62 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/36329:PF3D7_0932300 ^@ http://purl.uniprot.org/uniprot/Q8I2J3 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/36329:PF3D7_1317900 ^@ http://purl.uniprot.org/uniprot/Q8IED7 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/36329:PF3D7_1219900 ^@ http://purl.uniprot.org/uniprot/Q8I5L3 ^@ Cofactor|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/36329:PF3D7_1402100 ^@ http://purl.uniprot.org/uniprot/Q8IM68 ^@ Similarity ^@ Belongs to the pseudouridine synthase Pus10 family. http://togogenome.org/gene/36329:PF3D7_0627800 ^@ http://purl.uniprot.org/uniprot/C6KTB4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/36329:PF3D7_1415400 ^@ http://purl.uniprot.org/uniprot/Q8ILU2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CASC3 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1113300 ^@ http://purl.uniprot.org/uniprot/Q8IIM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1428600 ^@ http://purl.uniprot.org/uniprot/Q8ILH8 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/36329:PF3D7_1112200 ^@ http://purl.uniprot.org/uniprot/Q8IIP1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/36329:PF3D7_1027100 ^@ http://purl.uniprot.org/uniprot/Q8IJD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MPP10 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1415000 ^@ http://purl.uniprot.org/uniprot/Q8ILU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/36329:PF3D7_0818400 ^@ http://purl.uniprot.org/uniprot/C0H4V7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0306900 ^@ http://purl.uniprot.org/uniprot/O97248 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/36329:PF3D7_0314100.1 ^@ http://purl.uniprot.org/uniprot/A0A143ZX23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0902800 ^@ http://purl.uniprot.org/uniprot/Q8I3C0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_0518300 ^@ http://purl.uniprot.org/uniprot/A0A5K1K7U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1431000 ^@ http://purl.uniprot.org/uniprot/Q8ILF5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/36329:PF3D7_1369700 ^@ http://purl.uniprot.org/uniprot/C0H5L8 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/36329:PF3D7_0105300 ^@ http://purl.uniprot.org/uniprot/Q8I288 ^@ Similarity ^@ Belongs to the CAP family. http://togogenome.org/gene/36329:PF3D7_0919600 ^@ http://purl.uniprot.org/uniprot/Q8I2V7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/36329:PF3D7_1113900 ^@ http://purl.uniprot.org/uniprot/Q7KQK7 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/36329:PF3D7_1409200.1 ^@ http://purl.uniprot.org/uniprot/Q8IM04 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1303500 ^@ http://purl.uniprot.org/uniprot/Q8IET0 ^@ Similarity ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family. http://togogenome.org/gene/36329:PF3D7_1143900 ^@ http://purl.uniprot.org/uniprot/Q8IHS6 ^@ Function|||Similarity ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ATP, which is converted to ADP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. http://togogenome.org/gene/36329:PF3D7_1022700 ^@ http://purl.uniprot.org/uniprot/Q8IJH8 ^@ Similarity ^@ Belongs to the phospholipid scramblase family. http://togogenome.org/gene/36329:PF3D7_1007000 ^@ http://purl.uniprot.org/uniprot/Q8IJX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0916000 ^@ http://purl.uniprot.org/uniprot/Q8I2Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1015900 ^@ http://purl.uniprot.org/uniprot/Q8IJN7 ^@ Cofactor|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the enolase family.|||Binds 2 Mg(2+) ions per subunit (PubMed:25787157). Mg(2+) is required for catalysis and for stabilizing the dimer (PubMed:25787157). Unlike for mammalian and yeast enolases, Mg(2+) is dispensable to form an active closed conformation (PubMed:25787157). Inhibited by high levels of Mg(2+) (By similarity).|||Cell membrane|||Cell surface|||Cytoplasm|||During the asexual blood stage, expressed in rings, trophozoites, schizonts and merozoites (at protein level).|||Glycolytic enzyme that catalyzes the conversion of 2-phosphoglycerate to phosphoenolpyruvate (PubMed:19268421, PubMed:25787157). In addition to glycolysis, involved in various processes such as parasite development and invasion (By similarity). Plays an essential role during ookinete invasion of the mosquito vector midgut by mediating the interaction of the ookinete with the midgut epithelium and, further, by binding to mammalian host plasminogen in the blood meal, whose conversion to active plasmin promotes the invasion process (By similarity).|||Homodimer (PubMed:19268421, PubMed:25787157). Forms a complex at least composed of DegP, ENO and HSP70 (PubMed:24494818). Interacts with G-actin (PubMed:19642995). Interacts (via the DKSLVK motif) with mammalian host PLG/plasminogen (present in the mosquito blood meal); the interaction occurs at the ookinete cell surface and is required for ookinete invasion of the mosquito midgut (PubMed:19642995). Interacts with A.gambiae EBP; depending on the Plasmodium species, the interaction is either involved in ookinete invasion of the mosquito midgut (P.berghei) or is dispensable (P.falciparum) (By similarity).|||Nucleus|||The DKSLVK motif binds to the lysine-binding Kringle domains of plasminogen from various mammalian species (By similarity). This motif is present only in enolases of plant and several microbial pathogens including Plasmodium species (By similarity).|||The pentapeptide insert motif is required for the stabilization of the apo-enzyme in an active closed conformation, independently of Mg(2+) binding (PubMed:19268421, PubMed:25787157). The motif is also required for homodimerization (PubMed:19268421, PubMed:25787157). This motif is only present in Apicomplexa and plant enolases (Probable).|||Vacuole|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0911000 ^@ http://purl.uniprot.org/uniprot/C0H532 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGC family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1232000 ^@ http://purl.uniprot.org/uniprot/Q8I5A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/36329:PF3D7_0406100 ^@ http://purl.uniprot.org/uniprot/Q6ZMA8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/36329:PF3D7_0708500 ^@ http://purl.uniprot.org/uniprot/Q8IC04 ^@ Similarity ^@ Belongs to the NKAP family. http://togogenome.org/gene/36329:PF3D7_0614500 ^@ http://purl.uniprot.org/uniprot/C6KSY6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL19 family. http://togogenome.org/gene/36329:PF3D7_0811200 ^@ http://purl.uniprot.org/uniprot/Q8IAU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0316100 ^@ http://purl.uniprot.org/uniprot/Q9NDU6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/36329:PF3D7_1034000 ^@ http://purl.uniprot.org/uniprot/Q8IJ69 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/36329:PF3D7_0212300 ^@ http://purl.uniprot.org/uniprot/O96203 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family.|||Cytoplasm|||Heterodimer of two subunits, one of which binds GTP. http://togogenome.org/gene/36329:PF3D7_0821800 ^@ http://purl.uniprot.org/uniprot/C0H4W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Endoplasmic reticulum membrane|||Membrane|||Necessary for protein translocation in the endoplasmic reticulum. http://togogenome.org/gene/36329:PF3D7_1468200 ^@ http://purl.uniprot.org/uniprot/Q8IKF5 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/36329:PF3D7_1216300 ^@ http://purl.uniprot.org/uniprot/Q8I5P4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1427600 ^@ http://purl.uniprot.org/uniprot/Q8ILI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1021600 ^@ http://purl.uniprot.org/uniprot/Q8IJI7 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. http://togogenome.org/gene/36329:PF3D7_1441400 ^@ http://purl.uniprot.org/uniprot/Q8IL56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1323500 ^@ http://purl.uniprot.org/uniprot/Q8I6Z5 ^@ Activity Regulation|||Caution|||Developmental Stage|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Component of a complex composed of SPC25 and PMV; the interaction is mediated via the transmembrane domains (PubMed:30127496). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the recognition and import of PEXEL motif-containing proteins into the ER for subsequent export (PubMed:30127496).|||During the asexual blood stage, plays an essential role in the export of several proteins into the host erythrocytes by cleaving the pentameric localization motif RxLxE/Q/D (termed Plasmodium export element (PEXEL)) located downstream of the N-terminal secretory signal sequence (PubMed:20130643, PubMed:20130644, PubMed:24983235, PubMed:30127496, PubMed:30517136). Specifically, cleaves after the leucine residue in the RxLxE/Q/D (or RxLxxE) motif of exported proteins including RESA, EMP2, EMP3, KAHRP, RIF/Rifin and STEVOR (PubMed:20130643, PubMed:20130644, PubMed:23387285, PubMed:25447707, PubMed:25986559, PubMed:24983235). Also, by regulating protein export, plays an essential role in gametocyte development and thus, parasite transmission to the mosquito vector (By similarity).|||Endoplasmic reticulum membrane|||Expressed during the asexual blood stage; expression is low at the ring stage and then increases through the trophozoite and schizont stages (at protein level).|||Inhibited by peptidomimetic inhibitor WEHI-842 (PubMed:26214367). Inhibited by Cu(2+) and Hg(2+) (PubMed:25447707).|||It is not clear if the zymogen has a cleavable propeptide (PubMed:25447707). In vitro, appears to be cleaved between Asn-80 and Ala-81 (PubMed:25447707). Cleavage of the putative propeptide is dispensable for catalytic activity (PubMed:25447707, PubMed:25986559).|||It is unclear if PMV is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.|||The transmembrane domain is essential for localization to the endoplasmic reticulum. http://togogenome.org/gene/36329:PF3D7_1124900 ^@ http://purl.uniprot.org/uniprot/Q8IIB4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/36329:PF3D7_1432900 ^@ http://purl.uniprot.org/uniprot/Q8ILD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF-assemblin family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0607700 ^@ http://purl.uniprot.org/uniprot/C6KSS5 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1409500 ^@ http://purl.uniprot.org/uniprot/Q8IM00 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1349800 ^@ http://purl.uniprot.org/uniprot/Q8IDK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/36329:PF3D7_0317000 ^@ http://purl.uniprot.org/uniprot/O77396 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0522800 ^@ http://purl.uniprot.org/uniprot/Q8I3N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0618700 ^@ http://purl.uniprot.org/uniprot/C6KT27 ^@ Similarity ^@ Belongs to the TRAPP small subunits family. BET3 subfamily. http://togogenome.org/gene/36329:PF3D7_0912800 ^@ http://purl.uniprot.org/uniprot/Q8I324 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRM6/GCD10 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1309600 ^@ http://purl.uniprot.org/uniprot/Q8IEL9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/36329:PF3D7_0904400 ^@ http://purl.uniprot.org/uniprot/Q8I3A5 ^@ Similarity ^@ Belongs to the SPCS3 family. http://togogenome.org/gene/36329:PF3D7_0730100 ^@ http://purl.uniprot.org/uniprot/Q8IBF9 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/36329:PF3D7_1357800 ^@ http://purl.uniprot.org/uniprot/C0H5I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1457000 ^@ http://purl.uniprot.org/uniprot/Q8IKQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1404000 ^@ http://purl.uniprot.org/uniprot/Q8IM54 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1322500 ^@ http://purl.uniprot.org/uniprot/Q8IE90 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_1431500 ^@ http://purl.uniprot.org/uniprot/Q8ILF0 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/36329:PF3D7_1010800 ^@ http://purl.uniprot.org/uniprot/Q8IJT7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/36329:PF3D7_1103100 ^@ http://purl.uniprot.org/uniprot/Q8IIX0 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family. http://togogenome.org/gene/36329:PF3D7_1454100 ^@ http://purl.uniprot.org/uniprot/Q8I718 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/36329:PF3D7_1003500 ^@ http://purl.uniprot.org/uniprot/Q8IK02 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/36329:PF3D7_1214300 ^@ http://purl.uniprot.org/uniprot/C6S3K4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/36329:PF3D7_0626700 ^@ http://purl.uniprot.org/uniprot/C6KTA3 ^@ Similarity ^@ Belongs to the MYG1 family. http://togogenome.org/gene/36329:PF3D7_0829200 ^@ http://purl.uniprot.org/uniprot/Q8IBC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0303700 ^@ http://purl.uniprot.org/uniprot/O97227 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1309700 ^@ http://purl.uniprot.org/uniprot/Q8IEL8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0215900 ^@ http://purl.uniprot.org/uniprot/O96238 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_0728000 ^@ http://purl.uniprot.org/uniprot/Q8IBH7 ^@ Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Expressed during the asexual blood stage, including rings, trophozoites, schizonts (at protein level) (PubMed:22355110, PubMed:29241041). Expressed in male and female gametocytes (at protein level) (PubMed:22355110).|||Functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA (By similarity). May regulate protein translation in response to amino acid starvation (Probable). May regulate protein at various stages of parasite development (Probable).|||Phosphorylated at Ser-59 by eIK1 in response to amino acid starvation (PubMed:19435497). Phosphorylates at Ser-59 in schizonts and gametocytes but not in rings and young trophozoites (PubMed:22355110, PubMed:29241041). Phosphorylates at Ser-59 by eIK2 in salivary gland sporozoites but not in midgut and hemocoel sporozoites (By similarity). Dephosphorylated at Ser-59 by UIS2 (PubMed:26735921). Phosphorylation of eIF2alpha subunit of the pre-initiation complex eIF2 inhibits recycling of inactive eIF2-GDP to active eIF2-GTP by limiting the activity of the guanine nucleotide exchange factor eIF2B and thus, inhibits protein translation (PubMed:19435497).|||Stress granule http://togogenome.org/gene/36329:PF3D7_0509100 ^@ http://purl.uniprot.org/uniprot/Q8I413 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0307200 ^@ http://purl.uniprot.org/uniprot/O97250 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/36329:PF3D7_0508300 ^@ http://purl.uniprot.org/uniprot/Q8I420 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1211300 ^@ http://purl.uniprot.org/uniprot/Q8I5T7 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/36329:PF3D7_0627400 ^@ http://purl.uniprot.org/uniprot/C6KTB0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM22 complex.|||Essential core component of the TIM22 complex, a complex that mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. In the TIM22 complex, it constitutes the voltage-activated and signal-gated channel. Forms a twin-pore translocase that uses the membrane potential as external driving force in 2 voltage-dependent steps.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0422400 ^@ http://purl.uniprot.org/uniprot/Q8IFP2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS19 family. http://togogenome.org/gene/36329:PF3D7_0611000 ^@ http://purl.uniprot.org/uniprot/C6KSV5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1145100 ^@ http://purl.uniprot.org/uniprot/Q8IHR6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/36329:PF3D7_1355500 ^@ http://purl.uniprot.org/uniprot/Q8IDE7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-5 (PP-T) subfamily. http://togogenome.org/gene/36329:PF3D7_1009000 ^@ http://purl.uniprot.org/uniprot/Q8IJV5 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/36329:PF3D7_0528100 ^@ http://purl.uniprot.org/uniprot/Q8I3I6 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/36329:PF3D7_0524800 ^@ http://purl.uniprot.org/uniprot/Q8I3L7 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/36329:PF3D7_0318200 ^@ http://purl.uniprot.org/uniprot/O77375 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1431900 ^@ http://purl.uniprot.org/uniprot/Q8ILE6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/36329:PF3D7_0207600 ^@ http://purl.uniprot.org/uniprot/Q9TY95 ^@ Caution|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Cell membrane|||Conditional knockout at the merozoite stage, does not cause any defect in schizont morphology, merozoite number and maturation initially. During the subsequent invasive cycle in host erythrocytes, merozoite replication is severely impaired due to a premature rupture of the parasitophorous vacuole and erythrocyte membranes resulting in an inefficient dispersal of released merozoites.|||Expressed during parasite asexual blood stages, specifically in late trophozoite and schizont stages (at protein level).|||In contrast to other serine-repeat antigen proteins (SERA) of the peptidase C1 family, contains a serine residue at the position of the canonical catalytic cysteine and has been shown to lack protease activity. However, other studies show that it has protease activity towards synthetic peptides in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996).|||Interacts (via C-terminus) with human VTN (via hemopexin repeat 2); may form heterotetramers of two VTN and SERA5 P47 heterodimers; the interaction may protect merozoites from phagocytosis by host monocytes; VTN glycosylation appears to be dispensable for the interaction.|||Just prior to merozoite egress from host erythrocytes, proteolytically cleaved into multiple fragments (PubMed:18083098, PubMed:25599609, PubMed:24769454). Cleaved by SUB1 into p47 and p73, p73 is further cleaved by SUB1 into p56 and p18 and p56 is further processed into p50 by an unidentified protease (PubMed:25599609, PubMed:18083098). p47 remains covalently associated with p18 via disulfide bond (PubMed:25599609). p47 can be processed into p25n and p25c by SUB1 (PubMed:25599609, PubMed:18083098). p25c and p25n remain associated with p18 (PubMed:25599609). Proteolytic processing is essential for merozoite egress from host erythrocytes (PubMed:28683142). The cleavage of the propeptide to produce p50 is necessary for protease activity and to promote merozoite egress (PubMed:24769454).|||May interact (via C-terminus) with PTKL (via SAM domain).|||May prevent merozoite phagocytosis by host monocytes via interaction with host VTN at the merozoite surface (By similarity). Plays a role in parasite growth (By similarity).|||Monomer (PubMed:13679369, PubMed:25599609). Interacts with kinase CPK1/CDPK1 at the schizont stage (PubMed:29716996).|||Parasitophorous vacuole|||Phosphorylation by CPK1/CDPK1 increases SERA5 protease activity towards a synthetic peptide in vitro.|||Plays an essential role during the asexual blood stage development by controlling the kinetics of merozoite egress from host erythrocytes (PubMed:25599609, PubMed:28683142). Specifically, prevents premature rupture of the parasitophorous vacuole and host erythrocyte membranes (PubMed:28683142).|||Produced during parasite asexual blood stages, specifically at the merozoite stage just prior to egress (at protein level).|||Protease activity is controversial (PubMed:25599609). Has been shown in a number of studies to have protease activity towards a synthetic peptide in vitro (PubMed:13679369, PubMed:24769454, PubMed:29716996). Has also been shown to lack protease activity towards a synthetic peptide in vitro (PubMed:25599609).|||Secreted http://togogenome.org/gene/36329:PF3D7_1474800 ^@ http://purl.uniprot.org/uniprot/Q8IK90 ^@ Similarity ^@ Belongs to the peptidase T1A family. http://togogenome.org/gene/36329:PF3D7_1453700 ^@ http://purl.uniprot.org/uniprot/Q8IKU1 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/36329:PF3D7_0422700 ^@ http://purl.uniprot.org/uniprot/Q8IFN9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_0612800 ^@ http://purl.uniprot.org/uniprot/C6KSX1 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cell surface http://togogenome.org/gene/36329:PF3D7_1412600 ^@ http://purl.uniprot.org/uniprot/Q8ILW8 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/36329:PF3D7_1206500 ^@ http://purl.uniprot.org/uniprot/Q8I5Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0827500 ^@ http://purl.uniprot.org/uniprot/C0H4Y5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL21 family. http://togogenome.org/gene/36329:PF3D7_1030100 ^@ http://purl.uniprot.org/uniprot/Q8IJA4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0623500 ^@ http://purl.uniprot.org/uniprot/C6KT71 ^@ Similarity|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1427900 ^@ http://purl.uniprot.org/uniprot/Q8ILI6 ^@ Similarity ^@ Belongs to the ANP32 family. http://togogenome.org/gene/36329:PF3D7_0606100 ^@ http://purl.uniprot.org/uniprot/C6KSQ9 ^@ Similarity ^@ Belongs to the RRM NELF-E family. http://togogenome.org/gene/36329:PF3D7_1005700 ^@ http://purl.uniprot.org/uniprot/Q8IJY3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/36329:PF3D7_1404400 ^@ http://purl.uniprot.org/uniprot/Q8IM50 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/36329:PF3D7_1341300 ^@ http://purl.uniprot.org/uniprot/C0H5G3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/36329:PF3D7_0627900 ^@ http://purl.uniprot.org/uniprot/C6KTB5 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family. http://togogenome.org/gene/36329:PF3D7_0515800 ^@ http://purl.uniprot.org/uniprot/Q8I3V0 ^@ Similarity ^@ Belongs to the BolA/IbaG family. http://togogenome.org/gene/36329:PF3D7_0318800 ^@ http://purl.uniprot.org/uniprot/O77370 ^@ Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_0934100 ^@ http://purl.uniprot.org/uniprot/Q8I2H7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RAD3/XPD subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0319300 ^@ http://purl.uniprot.org/uniprot/O77397 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1407000 ^@ http://purl.uniprot.org/uniprot/Q8IM24 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0828400 ^@ http://purl.uniprot.org/uniprot/Q8IBB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1368700 ^@ http://purl.uniprot.org/uniprot/Q8ID23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0411900 ^@ http://purl.uniprot.org/uniprot/Q9U0H1 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/36329:PF3D7_1451100 ^@ http://purl.uniprot.org/uniprot/Q8IKW5 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/36329:PF3D7_1415700 ^@ http://purl.uniprot.org/uniprot/Q8ILT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1114800 ^@ http://purl.uniprot.org/uniprot/Q8IIL4 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1366600 ^@ http://purl.uniprot.org/uniprot/Q8ID42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding SRP family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/36329:PF3D7_1435000 ^@ http://purl.uniprot.org/uniprot/Q8ILB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX15/CtaA family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1329000 ^@ http://purl.uniprot.org/uniprot/Q8IE49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1353800 ^@ http://purl.uniprot.org/uniprot/Q8IDG3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/36329:PF3D7_0803200 ^@ http://purl.uniprot.org/uniprot/Q8IAN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF-assemblin family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1471500 ^@ http://purl.uniprot.org/uniprot/Q8IKC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0918900 ^@ http://purl.uniprot.org/uniprot/Q8I2W4 ^@ Similarity ^@ Belongs to the glutamate--cysteine ligase type 3 family. http://togogenome.org/gene/36329:PF3D7_1305300 ^@ http://purl.uniprot.org/uniprot/C0H5A0 ^@ Similarity ^@ Belongs to the GCN1 family. http://togogenome.org/gene/36329:PF3D7_0704200 ^@ http://purl.uniprot.org/uniprot/Q8IC28 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_1135900 ^@ http://purl.uniprot.org/uniprot/Q8II05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0207500 ^@ http://purl.uniprot.org/uniprot/Q9TY96 ^@ Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C1 family.|||Cysteine protease which plays an essential role in merozoite egress from host erythrocytes. May cleave host SPTB/beta spectrin and ANK1/ankyrin-1 which disrupts host erythrocyte actin cytoskeleton and leads to host erythrocyte cell membrane rupture.|||Expressed during parasite asexual blood stages, specifically at the schizont stage (at protein level).|||Just prior to merozoite egress from host erythrocytes, proteolytically cleaved by SUB1 to generate the active 75kDa form.|||Parasitophorous vacuole lumen|||Parasitophorous vacuole membrane http://togogenome.org/gene/36329:PF3D7_1331700 ^@ http://purl.uniprot.org/uniprot/Q8IE10 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1464000 ^@ http://purl.uniprot.org/uniprot/Q8IKJ7 ^@ Similarity ^@ Belongs to the VPS72/YL1 family. http://togogenome.org/gene/36329:PF3D7_1349200 ^@ http://purl.uniprot.org/uniprot/Q8IDK7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1342800 ^@ http://purl.uniprot.org/uniprot/Q8IDR1 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family. http://togogenome.org/gene/36329:PF3D7_0715100 ^@ http://purl.uniprot.org/uniprot/Q8IBU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AMY1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1229500 ^@ http://purl.uniprot.org/uniprot/Q8I5C4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1243600 ^@ http://purl.uniprot.org/uniprot/Q8I4Z4 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/36329:PF3D7_1014700 ^@ http://purl.uniprot.org/uniprot/Q8IJP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prohibitin family.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1224300 ^@ http://purl.uniprot.org/uniprot/Q8I5H4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0207700 ^@ http://purl.uniprot.org/uniprot/O96164 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_1311700 ^@ http://purl.uniprot.org/uniprot/Q8I6T6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Mitochondrion intermembrane space http://togogenome.org/gene/36329:PF3D7_0613500 ^@ http://purl.uniprot.org/uniprot/C6KSX7 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/36329:PF3D7_0420300 ^@ http://purl.uniprot.org/uniprot/Q8I1N6 ^@ Biotechnology|||Subcellular Location Annotation ^@ Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1216200 ^@ http://purl.uniprot.org/uniprot/Q8I5P5 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1223100 ^@ http://purl.uniprot.org/uniprot/Q7KQK0 ^@ Similarity ^@ Belongs to the cAMP-dependent kinase regulatory chain family. http://togogenome.org/gene/36329:PF3D7_0818000 ^@ http://purl.uniprot.org/uniprot/C0H4V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SNUT3 family.|||May play a role in mRNA splicing.|||Nucleus|||Part of a tri-snRNP complex. http://togogenome.org/gene/36329:PF3D7_0709300 ^@ http://purl.uniprot.org/uniprot/Q8IBZ6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 14 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0208600 ^@ http://purl.uniprot.org/uniprot/O96173 ^@ Similarity ^@ Belongs to the RRF family. http://togogenome.org/gene/36329:PF3D7_0317400 ^@ http://purl.uniprot.org/uniprot/O77383 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS2/PSF2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0508200 ^@ http://purl.uniprot.org/uniprot/C0H4D2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1211000 ^@ http://purl.uniprot.org/uniprot/Q8I5U0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0204500 ^@ http://purl.uniprot.org/uniprot/O96142 ^@ Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/36329:PF3D7_0822300 ^@ http://purl.uniprot.org/uniprot/Q8IB57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0820200 ^@ http://purl.uniprot.org/uniprot/Q8IB37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-II family.|||Functions in the biosynthesis of the anionic phospholipids phosphatidylglycerol and cardiolipin.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_0529500 ^@ http://purl.uniprot.org/uniprot/Q8I3H2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1460400 ^@ http://purl.uniprot.org/uniprot/Q8IKM8 ^@ Developmental Stage|||Function|||Similarity ^@ Belongs to the peptidase C12 family.|||Expressed during the parasite blood stage, in schizonts (at protein level).|||Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8 (PubMed:17371404, PubMed:31658303, PubMed:20042598). Essential for parasite blood stage survival (PubMed:20042598). http://togogenome.org/gene/36329:PF3D7_0718000 ^@ http://purl.uniprot.org/uniprot/C0H4N5 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/36329:PF3D7_0729100 ^@ http://purl.uniprot.org/uniprot/C0H4Q1 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/36329:PF3D7_1432500 ^@ http://purl.uniprot.org/uniprot/Q8ILD7 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. http://togogenome.org/gene/36329:PF3D7_0715800 ^@ http://purl.uniprot.org/uniprot/Q8IBU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0801700 ^@ http://purl.uniprot.org/uniprot/C0H4Y4 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/36329:PF3D7_0704900 ^@ http://purl.uniprot.org/uniprot/Q8IC21 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/36329:PF3D7_0216800 ^@ http://purl.uniprot.org/uniprot/O96246 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/36329:PF3D7_1330700 ^@ http://purl.uniprot.org/uniprot/A0A5K1K957 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGU family.|||Component of the GPI transamidase complex. May be involved in the recognition of either the GPI attachment signal or the lipid portion of GPI.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0935300 ^@ http://purl.uniprot.org/uniprot/Q8I2G7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/36329:PF3D7_1311300 ^@ http://purl.uniprot.org/uniprot/Q8I6T7 ^@ Similarity|||Subunit ^@ Belongs to the ATPase gamma chain family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/36329:PF3D7_1341900 ^@ http://purl.uniprot.org/uniprot/Q8IDS0 ^@ Similarity ^@ Belongs to the V-ATPase D subunit family. http://togogenome.org/gene/36329:PF3D7_1466300 ^@ http://purl.uniprot.org/uniprot/Q8IKH3 ^@ Similarity ^@ Belongs to the proteasome subunit S1 family. http://togogenome.org/gene/36329:PF3D7_0103800 ^@ http://purl.uniprot.org/uniprot/Q8I2A2 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_0407500 ^@ http://purl.uniprot.org/uniprot/C0H498 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1011400 ^@ http://purl.uniprot.org/uniprot/Q8IJT1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1003700 ^@ http://purl.uniprot.org/uniprot/Q8IK00 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0718700 ^@ http://purl.uniprot.org/uniprot/Q8IBR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1439000 ^@ http://purl.uniprot.org/uniprot/Q8IL79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/36329:PF3D7_1346700 ^@ http://purl.uniprot.org/uniprot/Q8I6T1 ^@ Biotechnology|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell surface|||Gametocyte surface protein required for male fertility.|||Heterodimer; heterodimerizes with PF230.|||Promising transmission-blocking vaccine candidate: targeting the protein would prevent transmission of the parasite decreasing the malaria burden. However, efforts to produce full length recombinant protein in a functional conformation is difficult. Different approaches have been tested to produce a recombinant protein with display of its transmission-blocking epitopes. http://togogenome.org/gene/36329:PF3D7_0725000 ^@ http://purl.uniprot.org/uniprot/Q8IBK1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1323800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8G8 ^@ Similarity ^@ Belongs to the VPS52 family. http://togogenome.org/gene/36329:PF3D7_1412000 ^@ http://purl.uniprot.org/uniprot/Q8ILX4 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/36329:PF3D7_0317500 ^@ http://purl.uniprot.org/uniprot/O77382 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0613400 ^@ http://purl.uniprot.org/uniprot/Q6LFD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1130500 ^@ http://purl.uniprot.org/uniprot/Q8II59 ^@ Similarity ^@ Belongs to the COG2 family. http://togogenome.org/gene/36329:PF3D7_1420700 ^@ http://purl.uniprot.org/uniprot/Q8ILP3 ^@ Developmental Stage|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).|||Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186). Within the complex, interacts with RH5 (via N-terminus); the interaction tethers RH5 to the merozoite membrane (PubMed:28186186).|||Membrane receptor which tethers secreted RH5 to the merozoite membrane during merozoite invasion of host erythocytes. http://togogenome.org/gene/36329:PF3D7_0605300 ^@ http://purl.uniprot.org/uniprot/C6KSQ1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily. http://togogenome.org/gene/36329:PF3D7_0920800 ^@ http://purl.uniprot.org/uniprot/Q8I2U5 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/36329:PF3D7_1109400 ^@ http://purl.uniprot.org/uniprot/Q8IIR2 ^@ Similarity ^@ Belongs to the bystin family. http://togogenome.org/gene/36329:PF3D7_0320100 ^@ http://purl.uniprot.org/uniprot/O97323 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0408500 ^@ http://purl.uniprot.org/uniprot/Q7K734 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA1 and PCNA2 (PubMed:26251451). Three molecules of FEN1 bind to one PCNA trimer with each molecule binding to one PCNA monomer. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Mitochondrion|||Phosphorylated. Phosphorylation upon DNA damage induces relocalization to the nuclear plasma.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. It enters the flap from the 5'-end and then tracks to cleave the flap base, leaving a nick for ligation. Also involved in the long patch base excision repair (LP-BER) pathway, by cleaving within the apurinic/apyrimidinic (AP) site-terminated flap. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA, and exhibits RNase H activity. Also involved in replication and repair of rDNA and in repairing mitochondrial DNA.|||nucleolus|||nucleoplasm http://togogenome.org/gene/36329:PF3D7_1115900 ^@ http://purl.uniprot.org/uniprot/Q8IIK6 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_0207800 ^@ http://purl.uniprot.org/uniprot/O96165 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_0415400 ^@ http://purl.uniprot.org/uniprot/Q8I1T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes small subunit family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The zeta subunit may be involved in regulating the coat assembly and, hence, the rate of biosynthetic protein transport due to its association-dissociation properties with the coatomer complex. http://togogenome.org/gene/36329:PF3D7_1419300 ^@ http://purl.uniprot.org/uniprot/Q8ILQ7 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Belongs to the GST superfamily.|||Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. May also function as a storage protein or ligandin for parasitotoxic ferriprotoporphyrin IX (hemin).|||Homodimer. In the absence of ligands two homodimers may interact to form a tetramer.|||Inhibited by chloroquine, cibacron blue, ferriprotoporphyrin IX (hemin) and S-hexylglutathione. http://togogenome.org/gene/36329:PF3D7_1457300 ^@ http://purl.uniprot.org/uniprot/Q8IKQ7 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/36329:PF3D7_1350200 ^@ http://purl.uniprot.org/uniprot/Q8IDJ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/36329:PF3D7_0931900 ^@ http://purl.uniprot.org/uniprot/C0H582 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Although it belongs to the adenylate kinase family, lacks several residues involved in ATP and AMP binding and has no adenylate kinase activity.|||Belongs to the adenylate kinase family.|||Cytoplasm|||Lacks adenylate kinase activity. http://togogenome.org/gene/36329:PF3D7_0516100 ^@ http://purl.uniprot.org/uniprot/Q8I3U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/36329:PF3D7_1242400 ^@ http://purl.uniprot.org/uniprot/Q8I505 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1215300 ^@ http://purl.uniprot.org/uniprot/Q8I5Q3 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/36329:PF3D7_1447000 ^@ http://purl.uniprot.org/uniprot/Q8IL02 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS5 family. http://togogenome.org/gene/36329:PF3D7_1364100 ^@ http://purl.uniprot.org/uniprot/Q8ID66 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell surface|||During the asexual blood stage, recruits host complement factor H CFH to the surface of merozoites resulting in the down-regulation of the host complement alternative pathway and thus, protecting merozoites from complement-mediated lysis.|||Expressed during the parasite blood stage, specifically in schizonts (at protein level).|||In strain D10, causes a loss of binding of human CFH to the merozoite surface resulting in a 7-fold increase in host complement-mediated merozoite lysis.|||Interacts with host complement factor CFH isoform 1 (via sushi 4-6 domains) and CFH isoform FHL-1 (via sushi 4-6 domains); this interaction recruits CFH onto the merozoite surface preventing complement-mediated cell lysis (PubMed:26700768). The interaction does not affect CFH activity (PubMed:26700768). http://togogenome.org/gene/36329:PF3D7_0614900 ^@ http://purl.uniprot.org/uniprot/C6KSZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1212600.1 ^@ http://purl.uniprot.org/uniprot/C6S3K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM208 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1134800 ^@ http://purl.uniprot.org/uniprot/Q8II16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/36329:PF3D7_1309100 ^@ http://purl.uniprot.org/uniprot/Q8IEM3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/36329:PF3D7_1322000 ^@ http://purl.uniprot.org/uniprot/Q8IE96 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/36329:PF3D7_1362200 ^@ http://purl.uniprot.org/uniprot/Q8ID85 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/36329:PF3D7_1208300 ^@ http://purl.uniprot.org/uniprot/Q8I0V5 ^@ Similarity ^@ Belongs to the acyl carrier protein (ACP) family. http://togogenome.org/gene/36329:PF3D7_0614200 ^@ http://purl.uniprot.org/uniprot/C6KSY3 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/36329:PF3D7_1026800 ^@ http://purl.uniprot.org/uniprot/Q8IJD4 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the universal ribosomal protein uS2 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable). Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits (By similarity).|||Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_1331300 ^@ http://purl.uniprot.org/uniprot/Q8IE14 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Catalytic component of the signal peptidase complex (SPC) which catalyzes the cleavage of N-terminal signal sequences from nascent proteins as they are translocated into the lumen of the endoplasmic reticulum (PubMed:18054093, PubMed:30127496). Specifically cleaves N-terminal signal peptides that contain a hydrophobic alpha-helix (h-region) shorter than 18-20 amino acids (By similarity).|||Causes a reduction in parasite growth in the host erythrocyte (PubMed:30127496, PubMed:18054093). Reduces levels of the mature form of SERA5 but not of PEXEL-containing proteins (PubMed:30127496).|||Component of the signal peptidase complex (SPC) composed of a catalytic subunit SEC11/SPC21 and three accessory subunits SPC25, SPC3/SPC22, SPC1/SPC12 (PubMed:30127496). Within the complex, interacts with SPC25 (PubMed:30127496). The complex induces a local thinning of the ER membrane which is used to measure the length of the signal peptide (SP) h-region of protein substrates (By similarity). This ensures the selectivity of the complex towards h-regions shorter than 18-20 amino acids (By similarity). The complex interacts with the SEC61 channel-forming translocon complex and is involved in the import of classical signal sequence-containing proteins (PubMed:30127496).|||Endoplasmic reticulum membrane|||Expressed during the asexual blood stage, including ring, trophozoite and schizont stages (at protein level).|||Phosphorylated (PubMed:18054093). Phosphorylation increases catalytic activity (PubMed:18054093).|||Phosphorylation increases catalytic activity (PubMed:18054093). Ca(2+) slightly increases catalytic activity in vitro (PubMed:18054093).|||The C-terminal short (CTS) helix is essential for catalytic activity (By similarity). It may be accommodated as a transmembrane helix in the thinned membrane environment of the complex, similarly to the signal peptide in the complex substrates (By similarity). http://togogenome.org/gene/36329:PF3D7_0405200 ^@ http://purl.uniprot.org/uniprot/Q8I1X7 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Function|||Polymorphism|||Subcellular Location Annotation ^@ Antibodies against CERLI2 severely reduces parasitemia, suggesting that CERLI2 is a potential vaccine candidate.|||Cell membrane|||During parasite asexual blood stages, expressed in trophozoites and at the schizont stage (at protein level).|||Host cell membrane|||Impairs merozoite invasion of host erythrocytes at, or prior to, the formation of the tight junction (PubMed:35140336). Merozoite development and egress following schizont rupture are not affected (PubMed:35140336). Inhibits rhoptry bulb RAP1 processing but not secretion of rhoptry neck proteins RH4 and RON4 (PubMed:35140336). Causes defects in rhoptry morphology which are narrower and more elongated (PubMed:35140336). No defect in microneme secretion (PubMed:35140336).|||Plays an important role in rhoptry physiology and thus is essential for merozoite invasion of host erythrocytes.|||The number of deca-peptide repeats in the C-terminus varies across P.falciparum strains (PubMed:19777263). Strain 3D7 has 12 copies; Dd2 has 14 copies; Hondura-1, FCC1, FCC2, and T996 have 17 copies; and strain D10 and FCR3 have 19 copies (PubMed:19777263).|||rhoptry membrane http://togogenome.org/gene/36329:PF3D7_0420200 ^@ http://purl.uniprot.org/uniprot/Q8I1N7 ^@ Similarity ^@ Belongs to the endoribonuclease YbeY family. http://togogenome.org/gene/36329:PF3D7_0416400 ^@ http://purl.uniprot.org/uniprot/C0H4A7 ^@ Similarity ^@ Belongs to the HAT1 family. http://togogenome.org/gene/36329:PF3D7_1105700 ^@ http://purl.uniprot.org/uniprot/Q8IIU6 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/36329:PF3D7_1363300 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8K5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/36329:PF3D7_0413800 ^@ http://purl.uniprot.org/uniprot/Q8I1U9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/36329:PF3D7_1249500 ^@ http://purl.uniprot.org/uniprot/Q8I4T9 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/36329:PF3D7_1361400 ^@ http://purl.uniprot.org/uniprot/Q8ID92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin-binding proteins ADF family.|||Cytoplasm|||Interacts with monomeric actin, does not bind to actin polymers.|||Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1342400 ^@ http://purl.uniprot.org/uniprot/Q8IDR5 ^@ Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/36329:PF3D7_0308600 ^@ http://purl.uniprot.org/uniprot/O77325 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/36329:PF3D7_0828700 ^@ http://purl.uniprot.org/uniprot/Q8IBB8 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0504400 ^@ http://purl.uniprot.org/uniprot/Q8I457 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX21/DDX50 subfamily. http://togogenome.org/gene/36329:PF3D7_0703800 ^@ http://purl.uniprot.org/uniprot/Q8IC32 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0810400 ^@ http://purl.uniprot.org/uniprot/C0H4T7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0322100 ^@ http://purl.uniprot.org/uniprot/C0H484 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fungal TPase family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0506200 ^@ http://purl.uniprot.org/uniprot/Q8I440 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0208200 ^@ http://purl.uniprot.org/uniprot/O96169 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KRR1 family.|||Component of the ribosomal small subunit (SSU) processome.|||Required for 40S ribosome biogenesis. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1314600 ^@ http://purl.uniprot.org/uniprot/Q8IEG9 ^@ Activity Regulation|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LplA family.|||Catalyzes both the ATP-dependent activation of exogenously supplied lipoate to lipoyl-AMP and the transfer of the activated lipoyl onto the lipoyl domains of lipoate-dependent enzymes (PubMed:17244193, PubMed:25116855, PubMed:28543853). In the mitochondrion, functions as a redox switch between two lipoylation routes (PubMed:25116855). Senses the oxidation state of lipoate and determines which downstream enzymes will be lipoylated (PubMed:25116855). In low reducing conditions, uses lipoate in its oxidized ring form to lipoylate glycine cleavage system H-protein GCVH (PubMed:17244193, PubMed:25116855, PubMed:28543853). In high reducing conditions and together with LipL2, uses reduced lipoate (dihydrolipoate) to lipoylate the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha-ketoglutarate dehydrogenase complex KDH. LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction (PubMed:17244193, PubMed:25116855).|||Expressed during the asexual blood stage, predominantly at the ring and schizont stages (at protein level).|||Inhibited by the lipoate analog 8-bromo-octanoate (BrO) (PubMed:17244193). Catalytic activity is increased in the presence of Mg(2+) (PubMed:17244193).|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1233900 ^@ http://purl.uniprot.org/uniprot/Q8I583 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/36329:PF3D7_0516300 ^@ http://purl.uniprot.org/uniprot/Q8I3U5 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/36329:PF3D7_0923600 ^@ http://purl.uniprot.org/uniprot/Q8I2S0 ^@ Caution|||Function|||Subcellular Location Annotation ^@ In the mitochondrion and together with LipL1, involved in the lipoylation of the E2 component of the branched chain alpha-ketoacid dehydrogenase complex BCKDH-E2/BCDH and the E2 component of the alpha -ketoglutarate dehydrogenase complex KDH (PubMed:25116855). LipL1 is responsible for catalysing the activation of lipoate, forming lipoyl-AMP while LipL2 is required but is not capable of catalyzing this reaction (PubMed:25116855). Although its role is unclear, it may catalyze the transfer of lipoyl groups from lipoyl-AMP to BCDH and KDH or act as an effector protein (PubMed:25116855).|||Lacks lipoate-protein ligase activity, probably due the loss of the lysine residue involved in the formation of the lipoyl-AMP reaction intermediate (PubMed:25116855). However, in some studies appears to be able to partially rescue ligase activity in E.coli lacking ligases lplA and lipB (PubMed:17244193, PubMed:18069893).|||Mitochondrion|||apicoplast http://togogenome.org/gene/36329:PF3D7_0217800 ^@ http://purl.uniprot.org/uniprot/O96258 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS26 family. http://togogenome.org/gene/36329:PF3D7_0931600 ^@ http://purl.uniprot.org/uniprot/Q8I2J9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in spermatogenesis.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1126900 ^@ http://purl.uniprot.org/uniprot/Q8II94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0212700 ^@ http://purl.uniprot.org/uniprot/O96208 ^@ Similarity ^@ Belongs to the SRR1 family. http://togogenome.org/gene/36329:PF3D7_0306400 ^@ http://purl.uniprot.org/uniprot/O97245 ^@ Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1459300 ^@ http://purl.uniprot.org/uniprot/Q8IKN8 ^@ Similarity ^@ Belongs to the OPA3 family. http://togogenome.org/gene/36329:PF3D7_1351600 ^@ http://purl.uniprot.org/uniprot/Q8IDI4 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/36329:PF3D7_1444800 ^@ http://purl.uniprot.org/uniprot/Q7KQL9 ^@ Activity Regulation|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I fructose-bisphosphate aldolase family.|||Cytoplasm|||Expressed during parasite asexual blood stages, including in schizonts (at protein level).|||Homotetramer (PubMed:26289816). Interacts with TRAP (via cytoplasmic domain); the interaction prevents substrate binding and thereby inhibits aldolase activity (PubMed:26289816, PubMed:16321976) (Probable). Interacts with MTRAP (via cytoplasmic domain); MTRAP phosphorylation may increase the binding to FBPA (PubMed:16321976). Interact with RH1 (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with RH2b (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with RH4 (via cytoplasmic domain) (PubMed:22991428, PubMed:27607074). Interacts with AMA1 (via cytoplasmic domain); the interaction is weak, however it may be increased upon AMA1 phosphorylation (PubMed:27607074). Interacts with EBA140 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with EBA175 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with EBA181 (via cytoplasmic domain); the interaction is weak (PubMed:27607074). Interacts with G-actin and F-actin (PubMed:25261592). May interact with ACT2/actin II; the interaction inhibits FBPA catalytic activity (By similarity). Interacts with human SLC4A1/band 3 (via N-terminus); the interaction inhibits FBPA catalytic activity (By similarity).|||Host cell membrane|||Membrane|||Plays a key role in glycolysis by catalyzing the cleavage of fructose 1,6-bisphosphate into dihydroxyacetone phosphate and glyceraldehyde 3-phosphate (PubMed:26289816). Independently of its catalytic activity, connects the actin filaments, and thus the actomyosin motor, to cell surface adhesins of the thrombospondin-related anonymous protein (TRAP), the erythrocyte binding ligand (EBL) and reticulocyte binding homolog (RH) protein families; this interaction is probably involved in transducing the motor force across the parasite surface required for sporozoite and ookinete gliding motility and merozoite invasion (PubMed:22991428, PubMed:25261592) (Probable). Stimulates actin polymerisation (PubMed:25261592).|||The cytoplasmic tail of TRAP and probably other adhesins acts as a competitive inhibitor as the binding sites of the glycolytic substrate fructose 1,6-bisphosphate and TRAP partially overlap. http://togogenome.org/gene/36329:PF3D7_1310000 ^@ http://purl.uniprot.org/uniprot/Q8IEL5 ^@ Similarity ^@ Belongs to the ATPase delta chain family. http://togogenome.org/gene/36329:PF3D7_0316600 ^@ http://purl.uniprot.org/uniprot/O77389 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1248000 ^@ http://purl.uniprot.org/uniprot/A0A144A1E9 ^@ Similarity ^@ Belongs to the tRNA-intron endonuclease family. http://togogenome.org/gene/36329:PF3D7_1426500 ^@ http://purl.uniprot.org/uniprot/Q8ILJ9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1248200 ^@ http://purl.uniprot.org/uniprot/Q8I4V2 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SLT11 family.|||Involved in pre-mRNA splicing (By similarity). Binds RNA (By similarity).|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Probable component of the spliceosome C complex.|||The C-terminal RRM domain and the zinc finger motif are necessary for RNA-binding. http://togogenome.org/gene/36329:PF3D7_1422800 ^@ http://purl.uniprot.org/uniprot/Q8ILM5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1430400 ^@ http://purl.uniprot.org/uniprot/Q8ILG0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation.|||Preautophagosomal structure membrane http://togogenome.org/gene/36329:PF3D7_1111500 ^@ http://purl.uniprot.org/uniprot/C6S3F0 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/36329:PF3D7_1207100 ^@ http://purl.uniprot.org/uniprot/Q8I5X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1218300 ^@ http://purl.uniprot.org/uniprot/Q8I5M5 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/36329:PF3D7_1020700 ^@ http://purl.uniprot.org/uniprot/Q8IJJ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA cytidine acetyltransferase family. NAT10 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||RNA cytidine acetyltransferase with specificity toward both 18S rRNA and tRNAs. Catalyzes the formation of N(4)-acetylcytidine (ac4C) in 18S rRNA. Required for early nucleolar cleavages of precursor rRNA at sites A0, A1 and A2 during 18S rRNA synthesis. Catalyzes the formation of ac4C in serine and leucine tRNAs. Requires a tRNA-binding adapter protein for full tRNA acetyltransferase activity but not for 18S rRNA acetylation.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1008400 ^@ http://purl.uniprot.org/uniprot/Q8IJW0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_1468800 ^@ http://purl.uniprot.org/uniprot/Q8IKE9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1333200 ^@ http://purl.uniprot.org/uniprot/Q8IDZ6 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/36329:PF3D7_1433300 ^@ http://purl.uniprot.org/uniprot/Q8ILD0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0805400 ^@ http://purl.uniprot.org/uniprot/C0H4R5 ^@ Similarity ^@ Belongs to the acetyltransferase family. MAK3 subfamily. http://togogenome.org/gene/36329:PF3D7_1248500 ^@ http://purl.uniprot.org/uniprot/Q8I4U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0908600 ^@ http://purl.uniprot.org/uniprot/Q8I365 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. TRM7 subfamily.|||Cytoplasm|||Methylates the 2'-O-ribose of nucleotides at positions 32 and 34 of the tRNA anticodon loop of substrate tRNAs. http://togogenome.org/gene/36329:PF3D7_0412100 ^@ http://purl.uniprot.org/uniprot/Q9U0G9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS12 family. http://togogenome.org/gene/36329:PF3D7_0218000 ^@ http://purl.uniprot.org/uniprot/O96260 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/36329:PF3D7_0810800 ^@ http://purl.uniprot.org/uniprot/Q8IAU3 ^@ Similarity ^@ In the C-terminal section; belongs to the DHPS family. http://togogenome.org/gene/36329:PF3D7_0716800 ^@ http://purl.uniprot.org/uniprot/Q8IBT2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1230400 ^@ http://purl.uniprot.org/uniprot/Q8I5B6 ^@ Similarity ^@ Belongs to the peptidase T1B family. HslV subfamily. http://togogenome.org/gene/36329:PF3D7_1468500.1 ^@ http://purl.uniprot.org/uniprot/Q8IKF2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/36329:PF3D7_0511700 ^@ http://purl.uniprot.org/uniprot/Q8I3Y9 ^@ Similarity ^@ Belongs to the CGI121/TPRKB family. http://togogenome.org/gene/36329:PF3D7_1251200 ^@ http://purl.uniprot.org/uniprot/Q8I4S2 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/36329:PF3D7_0503200 ^@ http://purl.uniprot.org/uniprot/Q8I469 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) that binds origins of replication. DNA-binding is ATP-dependent, however specific DNA sequences that define origins of replication have not been identified so far. ORC is required to assemble the pre-replication complex necessary to initiate DNA replication.|||Nucleus|||ORC is composed of six subunits. http://togogenome.org/gene/36329:PF3D7_1004000 ^@ http://purl.uniprot.org/uniprot/Q8IJZ7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/36329:PF3D7_1224000 ^@ http://purl.uniprot.org/uniprot/Q8I5H7 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I family. http://togogenome.org/gene/36329:PF3D7_0807500 ^@ http://purl.uniprot.org/uniprot/Q8IAR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1035000 ^@ http://purl.uniprot.org/uniprot/Q8IJ59 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/36329:PF3D7_1475300 ^@ http://purl.uniprot.org/uniprot/Q8IK85 ^@ Subcellular Location Annotation ^@ Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1444500 ^@ http://purl.uniprot.org/uniprot/Q8IL26 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Induction|||PTM|||Similarity ^@ Auto-phosphorylated.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.|||Down-regulated at the ring stage by melatonin.|||Expressed during the asexual blood stage, including rings, trophozoites and schizonts.|||In blood stage parasites, phosphorylates translation factor eIF2alpha in response to amino acid starvation (PubMed:19435497, PubMed:29241041). During the asexual blood stage, involved in the response to the host hormone melatonin which is used by the parasite to modulate its cell cycle (PubMed:32702775).|||No defect in erythrocyte asexual growth and gametocytogenesis (PubMed:19435497). No defect in the production of sporozoites in the mosquito vector (PubMed:19435497). In blood stage parasites, phosphorylation of eIF2alpha in response to amino-acid starvation is impaired (PubMed:19435497). During the asexual blood stage, increased in parasitemia induced by host melatonin is impaired (PubMed:32702775). http://togogenome.org/gene/36329:PF3D7_1247600 ^@ http://purl.uniprot.org/uniprot/A0A144A0S1 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/36329:PF3D7_1231500 ^@ http://purl.uniprot.org/uniprot/Q8I5A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1414900 ^@ http://purl.uniprot.org/uniprot/Q8ILU7 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/36329:PF3D7_0218500 ^@ http://purl.uniprot.org/uniprot/O96265 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/36329:PF3D7_1321600 ^@ http://purl.uniprot.org/uniprot/B3FEM7 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/36329:PF3D7_0519200 ^@ http://purl.uniprot.org/uniprot/Q8I3R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Vacuole membrane http://togogenome.org/gene/36329:PF3D7_0914200 ^@ http://purl.uniprot.org/uniprot/Q8I310 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/36329:PF3D7_0307100 ^@ http://purl.uniprot.org/uniprot/O97249 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS12 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).|||Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_1034700 ^@ http://purl.uniprot.org/uniprot/Q8IJ63 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/36329:PF3D7_0908300.1 ^@ http://purl.uniprot.org/uniprot/C0H526 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the plant tobamovirus multiplication TOM1 protein family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1345100 ^@ http://purl.uniprot.org/uniprot/Q8IDP4 ^@ Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thioredoxin family.|||Expressed during the parasite blood stage, including in rings, trophozoites, schizonts and merozoites (at protein level).|||Monomer (PubMed:25475729). Component of the Plasmodium translocon of exported proteins (PTEX) complex composed of HSP101, EXP2, PTEX150, PTEX88 and TRX2 (PubMed:19536257).|||Parasitophorous vacuole membrane|||Participates in various redox reactions through the reversible oxidation of its active center dithiol to a disulfide and catalyzes dithiol-disulfide exchange reactions (PubMed:16910770, PubMed:22355694). As part of the translocon PTEX complex, plays a role in the export of parasite proteins into the host erythrocyte (By similarity). The translocon PTEX complex is a multi-protein machinery resident in the parasite parasitophorous vacuolar membrane, responsible for protein secretion into host cells (PubMed:19536257). May contribute to the unfolding of proteins containing the PEXEL localization motif before their passage through the translocon or regulate the PTEX complex function (PubMed:19536257).|||The disulfide bond between Cys-82 and Cys-85 acts as a redox-active center and is reduced by thioredoxin reductase TRXR. http://togogenome.org/gene/36329:PF3D7_1234800 ^@ http://purl.uniprot.org/uniprot/Q8I574 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1302600 ^@ http://purl.uniprot.org/uniprot/Q8I701 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the deoxyhypusine hydroxylase family.|||Binds 2 Fe(2+) ions per subunit.|||Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor. http://togogenome.org/gene/36329:PF3D7_1145300 ^@ http://purl.uniprot.org/uniprot/C6S3G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRIPT family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1457700 ^@ http://purl.uniprot.org/uniprot/Q8IKQ3 ^@ Similarity ^@ Belongs to the CBF/MAK21 family. http://togogenome.org/gene/36329:PF3D7_0824600 ^@ http://purl.uniprot.org/uniprot/C0H4X5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the cytosolic Fe-S scaffold complex. Electrons are transferred from NADPH via a FAD- and FMN-containing diflavin oxidoreductase. Together with the diflavin oxidoreductase, also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit.|||Cytoplasm|||Mitochondrion intermembrane space|||Monomer.|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial MIA40-ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/36329:PF3D7_0629700 ^@ http://purl.uniprot.org/uniprot/C6KTD2 ^@ Biotechnology|||Developmental Stage|||Function|||Similarity ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Probable histone methyltransferase.|||constitutive pattern of expression. http://togogenome.org/gene/36329:PF3D7_0109300 ^@ http://purl.uniprot.org/uniprot/Q8I251 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1133300 ^@ http://purl.uniprot.org/uniprot/Q8II31 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/36329:PF3D7_1406100 ^@ http://purl.uniprot.org/uniprot/Q8IM33 ^@ Similarity ^@ Belongs to the TUB family. http://togogenome.org/gene/36329:PF3D7_1003300 ^@ http://purl.uniprot.org/uniprot/Q8IK04 ^@ Similarity ^@ Belongs to the acetyltransferase family. ARD1 subfamily. http://togogenome.org/gene/36329:PF3D7_0111900 ^@ http://purl.uniprot.org/uniprot/Q8I227 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/36329:PF3D7_0417200 ^@ http://purl.uniprot.org/uniprot/Q8I1R6 ^@ Function|||Similarity|||Subunit ^@ Bifunctional enzyme. Involved in de novo dTMP biosynthesis. Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, DNA precursor synthesis, and for the conversion of dUMP to dTMP.|||Homodimer.|||In the C-terminal section; belongs to the thymidylate synthase family.|||In the N-terminal section; belongs to the dihydrofolate reductase family. http://togogenome.org/gene/36329:PF3D7_1472100 ^@ http://purl.uniprot.org/uniprot/Q8IKB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0923000 ^@ http://purl.uniprot.org/uniprot/Q8I2S6 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_1317800 ^@ http://purl.uniprot.org/uniprot/C0H5C2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS19 family. http://togogenome.org/gene/36329:PF3D7_0520900 ^@ http://purl.uniprot.org/uniprot/P50250 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Adenosylhomocysteine is a competitive inhibitor of S-adenosyl-L-methionine-dependent methyl transferase reactions; therefore adenosylhomocysteinase may play a key role in the control of methylations via regulation of the intracellular concentration of adenosylhomocysteine.|||Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Homotetramer. http://togogenome.org/gene/36329:PF3D7_0322300 ^@ http://purl.uniprot.org/uniprot/O97295 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1430700 ^@ http://purl.uniprot.org/uniprot/Q8ILF7 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/36329:PF3D7_1441900 ^@ http://purl.uniprot.org/uniprot/Q8IL51 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1449400 ^@ http://purl.uniprot.org/uniprot/Q8IKY1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XPF family.|||Interacts with EME1 to form a DNA structure-specific endonuclease with substrate preference for branched DNA structures with a 5'-end at the branch nick. Typical substrates include 3'-flap structures, D-loops, replication forks and nicked Holliday junctions. May be required in mitosis for the processing of stalled or collapsed replication fork intermediates. May be required in meiosis for the repair of meiosis-specific double strand breaks subsequent to single-end invasion (SEI).|||Interacts with EME1.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0418500 ^@ http://purl.uniprot.org/uniprot/Q8I1Q2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/36329:PF3D7_1455900 ^@ http://purl.uniprot.org/uniprot/C6S3J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family. Polyprenol reductase subfamily.|||Endoplasmic reticulum membrane|||Membrane|||Plays a key role in early steps of protein N-linked glycosylation by being required for the conversion of polyprenol into dolichol. Dolichols are required for the synthesis of dolichol-linked monosaccharides and the oligosaccharide precursor used for N-glycosylation. Acts as a polyprenol reductase that promotes the reduction of the alpha-isoprene unit of polyprenols into dolichols in a NADP-dependent mechanism. http://togogenome.org/gene/36329:PF3D7_1439900 ^@ http://purl.uniprot.org/uniprot/Q7KQM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Catalyzes the interconversion of glyceraldehyde 3-phosphate and dihydroxyacetone phosphate in the glycolytic and gluconeogenic pathways.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_0107700 ^@ http://purl.uniprot.org/uniprot/B9ZSI6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1146000 ^@ http://purl.uniprot.org/uniprot/Q8IHQ8 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_1431600 ^@ http://purl.uniprot.org/uniprot/Q8ILE9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of ATP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/36329:PF3D7_1022300 ^@ http://purl.uniprot.org/uniprot/Q8IJI1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1340500 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8Z6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Nucleus|||spindle http://togogenome.org/gene/36329:PF3D7_0625000.1 ^@ http://purl.uniprot.org/uniprot/C6KT86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1126400 ^@ http://purl.uniprot.org/uniprot/Q8IIA0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1311100 ^@ http://purl.uniprot.org/uniprot/Q8IEK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MNS1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0919700 ^@ http://purl.uniprot.org/uniprot/Q8I2V6 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which may be involved in intracellular homeostatic regulation of pyridoxal 5'-phosphate (PLP), the active form of vitamin B6. http://togogenome.org/gene/36329:PF3D7_1115700 ^@ http://purl.uniprot.org/uniprot/Q8I6U4 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_1249900 ^@ http://purl.uniprot.org/uniprot/A0A144A0V8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0806600 ^@ http://purl.uniprot.org/uniprot/C0H4S3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0103400 ^@ http://purl.uniprot.org/uniprot/Q8I2A6 ^@ Biotechnology|||Cofactor|||Developmental Stage|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||Binds 1 zinc ion per subunit.|||Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1404100 ^@ http://purl.uniprot.org/uniprot/Q8IM53 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/36329:PF3D7_1445900 ^@ http://purl.uniprot.org/uniprot/Q8IL13 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_1012500 ^@ http://purl.uniprot.org/uniprot/Q8IJS0 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/36329:PF3D7_0813600 ^@ http://purl.uniprot.org/uniprot/Q8IAX2 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/36329:PF3D7_1405600 ^@ http://purl.uniprot.org/uniprot/Q8IM38 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/36329:PF3D7_1331600 ^@ http://purl.uniprot.org/uniprot/C0H5F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1402400 ^@ http://purl.uniprot.org/uniprot/Q8IM65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0903700 ^@ http://purl.uniprot.org/uniprot/Q6ZLZ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/36329:PF3D7_0316800 ^@ http://purl.uniprot.org/uniprot/O77395 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS8 family. http://togogenome.org/gene/36329:PF3D7_0828600 ^@ http://purl.uniprot.org/uniprot/Q8IBB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0718500 ^@ http://purl.uniprot.org/uniprot/Q8IBR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit alpha family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/36329:PF3D7_1235700 ^@ http://purl.uniprot.org/uniprot/Q8I0V2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/36329:PF3D7_1020900 ^@ http://purl.uniprot.org/uniprot/Q7KQL3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive GDP-bound form and an active GTP-bound form (PubMed:32144363). Intrinsic GTPase activity is almost undetectable in vitro (By similarity). Activated by a guanine nucleotide-exchange factor (GEF) and inactivated by GTPase-activating protein ARFGAP1 (PubMed:32144363).|||Belongs to the small GTPase superfamily. Arf family.|||Golgi apparatus membrane|||May interact with GTPase RAB5b.|||Small GTPase involved in protein trafficking between different compartments (PubMed:21045287). Modulates vesicle budding and uncoating within the Golgi complex (By similarity). In its GTP-bound form, triggers the recruitment of coatomer proteins to the Golgi membrane (By similarity). The hydrolysis of ARF1-bound GTP, which is mediated by ARFGAPs proteins, is required for dissociation of coat proteins from Golgi membranes and vesicles (By similarity). Regulates the transport of N-acylated AK2 to the parasitophorous vacuole membrane (PubMed:33604307). May be involved in the activation of lipid kinase PIP5K (PubMed:19171150). http://togogenome.org/gene/36329:PF3D7_1367700 ^@ http://purl.uniprot.org/uniprot/Q8ID31 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm|||Mitochondrion|||Monomer. http://togogenome.org/gene/36329:PF3D7_0302900 ^@ http://purl.uniprot.org/uniprot/O77312 ^@ Similarity ^@ Belongs to the exportin family. http://togogenome.org/gene/36329:PF3D7_0103200 ^@ http://purl.uniprot.org/uniprot/Q8I2A8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0720000 ^@ http://purl.uniprot.org/uniprot/Q8IBQ2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_0306200 ^@ http://purl.uniprot.org/uniprot/O97244 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/36329:PF3D7_1458900 ^@ http://purl.uniprot.org/uniprot/Q8IKP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0423800 ^@ http://purl.uniprot.org/uniprot/Q8IFM8 ^@ Biotechnology|||Caution|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:25583518, PubMed:27374406, PubMed:30542156). Following the establishment of the junction between the merozoite and the erythrocyte, CyRPA dissociates from the complex (PubMed:30542156). Within the complex, interacts with RH5 and RIPR (PubMed:28195530, PubMed:30542156). CyRPA recruits RIPR to RH5-P113-BSG complex; the formation of the PfRH5 adhesion complex increases the affinity of RH5 for BSG and probably leads to the release of RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186, PubMed:30542156).|||Conditional knockdown causes loss of cell growth and severely impairs merozoite invasion of erythrocytes. Attachment to and deformation of erythrocyte membrane is normal, however the subsequent step, which triggers an increase in Ca(2+) from the attached merozoite into the erythrocyte, is impaired.|||CyRPA shares structural homology with sialidases, however the 3 conserved arginine residues involved in substrate binding and the nucleophilic tyrosine residue are not conserved. Does not have sialidase/neuraminidase activity in vitro.|||CyRPA was thought to be GPI-anchored to the merozoite membrane (PubMed:25583518). However, a subsequent report shows that this was not the case (PubMed:27374406).|||Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:22593616, PubMed:25583518, PubMed:27374406, PubMed:28195530, PubMed:28195038). Required for the assembly of the PfRH5 adhesion complex (or invasion complex) composed of CyRPA, RH5 and RIPR at the interface between the merozoite and the host erythrocyte membranes (PubMed:25583518, PubMed:28186186, PubMed:28195530, PubMed:28195038, PubMed:30542156). This facilitates the binding of RH5 to host receptor BSG/basigin, which leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes and allows Ca(2+) release into the erythrocyte (PubMed:27374406, PubMed:28186186, PubMed:30542156).|||Expressed during parasite asexual blood stages, specifically at the schizont stage, in free merozoites, and at the very early ring stage but not in late ring and early trophozoite stages (at protein level).|||Host cell membrane|||N-glycosylated.|||Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.|||Secreted|||microneme lumen http://togogenome.org/gene/36329:PF3D7_1345700 ^@ http://purl.uniprot.org/uniprot/Q8I6T2 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/36329:PF3D7_1008700 ^@ http://purl.uniprot.org/uniprot/Q7KQL5 ^@ Developmental Stage|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains (Probable). A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells (Probable). Interacts with DCX/apicortin; the interaction stabilizes microtubule assembly (PubMed:33633135).|||Expressed during the parasite blood stage, including in trophozoites, schizonts and free merozoites (at protein level).|||Tamoxifen used to treat breast cancer blocks the interaction between apicortin and, alpha-tubulin 1 and beta-tubulin resulting in microtubule destabilization.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers (PubMed:33633135). Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1138600 ^@ http://purl.uniprot.org/uniprot/Q8IHX9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0512200 ^@ http://purl.uniprot.org/uniprot/Q8I3Y4 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic GSH synthase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/36329:PF3D7_1011700 ^@ http://purl.uniprot.org/uniprot/Q8IJS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD23 family.|||Cytoplasm|||Multiubiquitin chain receptor involved in modulation of proteasomal degradation. Involved in nucleotide excision repair.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1108700 ^@ http://purl.uniprot.org/uniprot/Q8IIR6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1105100 ^@ http://purl.uniprot.org/uniprot/Q8IIV1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_1366800 ^@ http://purl.uniprot.org/uniprot/C0H5K9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1203500 ^@ http://purl.uniprot.org/uniprot/Q8I610 ^@ Similarity ^@ Belongs to the SUA5 family. http://togogenome.org/gene/36329:PF3D7_1139300 ^@ http://purl.uniprot.org/uniprot/Q8IHX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1461500 ^@ http://purl.uniprot.org/uniprot/C6S3J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MND1 family.|||Nucleus|||Required for proper homologous chromosome pairing and efficient cross-over and intragenic recombination during meiosis. http://togogenome.org/gene/36329:PF3D7_0619900 ^@ http://purl.uniprot.org/uniprot/C6KT39 ^@ Similarity ^@ Belongs to the SF3A2 family. http://togogenome.org/gene/36329:PF3D7_1222400 ^@ http://purl.uniprot.org/uniprot/Q8I5J1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0930300 ^@ http://purl.uniprot.org/uniprot/Q8I0U8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0511500 ^@ http://purl.uniprot.org/uniprot/Q8I3Z1 ^@ Biotechnology|||Developmental Stage|||Subcellular Location Annotation ^@ Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0519000 ^@ http://purl.uniprot.org/uniprot/Q8I3R9 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/36329:PF3D7_0418100 ^@ http://purl.uniprot.org/uniprot/Q8I1Q6 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/36329:PF3D7_1242600 ^@ http://purl.uniprot.org/uniprot/Q8I503 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family. http://togogenome.org/gene/36329:PF3D7_0408300 ^@ http://purl.uniprot.org/uniprot/Q9U0K3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1429100 ^@ http://purl.uniprot.org/uniprot/Q8ILH3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/36329:PF3D7_1358700 ^@ http://purl.uniprot.org/uniprot/Q8IDB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1367600 ^@ http://purl.uniprot.org/uniprot/Q8ID32 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL10 family. http://togogenome.org/gene/36329:PF3D7_0812700 ^@ http://purl.uniprot.org/uniprot/Q8IAW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the U1 small nuclear ribonucleoprotein C family.|||Component of the spliceosomal U1 snRNP, which is essential for recognition of the pre-mRNA 5' splice-site and the subsequent assembly of the spliceosome. U1-C is directly involved in initial 5' splice-site recognition for both constitutive and regulated alternative splicing. The interaction with the 5' splice-site seems to precede base-pairing between the pre-mRNA and the U1 snRNA. Stimulates commitment or early (E) complex formation by stabilizing the base pairing of the 5' end of the U1 snRNA and the 5' splice-site region.|||Nucleus|||U1 snRNP is composed of the 7 core Sm proteins B/B', D1, D2, D3, E, F and G that assemble in a heptameric protein ring on the Sm site of the small nuclear RNA to form the core snRNP, and at least 3 U1 snRNP-specific proteins U1-70K, U1-A and U1-C. U1-C interacts with U1 snRNA and the 5' splice-site region of the pre-mRNA. http://togogenome.org/gene/36329:PF3D7_0515100 ^@ http://purl.uniprot.org/uniprot/Q8I3V7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0207100 ^@ http://purl.uniprot.org/uniprot/O96160 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1007900 ^@ http://purl.uniprot.org/uniprot/Q8IJW4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/36329:PF3D7_1434600 ^@ http://purl.uniprot.org/uniprot/Q8ILB8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1119500 ^@ http://purl.uniprot.org/uniprot/Q8IIH2 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/36329:PF3D7_0526500 ^@ http://purl.uniprot.org/uniprot/Q8I3K0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1321500.1 ^@ http://purl.uniprot.org/uniprot/Q8I6Z7 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.|||Cell membrane|||Endoplasmic reticulum membrane|||Expressed during the asexual blood stage, with highest levels in the late schizont stage.|||Plays a role in signal transduction by regulating the intracellular concentration of cyclic nucleotides cAMP and cGMP (PubMed:30794532). Catalyzes the hydrolysis of both cAMP and cGMP to 5'-AMP and 5'-GMP, respectively (PubMed:30794532). By regulating cAMP levels during the asexual blood stage and, thus PKA activation, required for merozoite invasion of erythrocytes and for the parasite development immediately following invasion (PubMed:30794532). http://togogenome.org/gene/36329:PF3D7_1132400 ^@ http://purl.uniprot.org/uniprot/Q8II41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1205900 ^@ http://purl.uniprot.org/uniprot/Q8I5Y6 ^@ Similarity ^@ Belongs to the TMCO4 family. http://togogenome.org/gene/36329:PF3D7_0205500 ^@ http://purl.uniprot.org/uniprot/O96150 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1107900 ^@ http://purl.uniprot.org/uniprot/Q8IIS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0404500 ^@ http://purl.uniprot.org/uniprot/Q8I1Y4 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Attenuated parasites that cannot commit to infection, even when they encounter with hepatocytes, resulting in continuous traversal of hepatocytes.|||Cell membrane|||Cell surface|||Involved in sporozoite infection of hepatocytes and replication therein. http://togogenome.org/gene/36329:PF3D7_0826700 ^@ http://purl.uniprot.org/uniprot/Q8IBA0 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. Ribosomal protein RACK1 subfamily. http://togogenome.org/gene/36329:PF3D7_1217600 ^@ http://purl.uniprot.org/uniprot/Q8I5N2 ^@ Similarity ^@ Belongs to the APC10 family. http://togogenome.org/gene/36329:PF3D7_1107400 ^@ http://purl.uniprot.org/uniprot/Q8IIS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Binds to single and double-stranded DNA and exhibits DNA-dependent ATPase activity. Underwinds duplex DNA.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0214200 ^@ http://purl.uniprot.org/uniprot/O96222 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/36329:PF3D7_1132500 ^@ http://purl.uniprot.org/uniprot/Q8II40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0514000 ^@ http://purl.uniprot.org/uniprot/C0H4D8 ^@ Similarity ^@ Belongs to the tubulin--tyrosine ligase family. http://togogenome.org/gene/36329:PF3D7_0708000 ^@ http://purl.uniprot.org/uniprot/C0H4M2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1460900.1 ^@ http://purl.uniprot.org/uniprot/Q8IKM3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS10 family. http://togogenome.org/gene/36329:PF3D7_0909400 ^@ http://purl.uniprot.org/uniprot/Q8I358 ^@ Similarity ^@ Belongs to the 5'-3' exonuclease family. XRN2/RAT1 subfamily. http://togogenome.org/gene/36329:PF3D7_1339800 ^@ http://purl.uniprot.org/uniprot/Q8IDT7 ^@ Similarity ^@ Belongs to the MOZART1 family. http://togogenome.org/gene/36329:PF3D7_0519100 ^@ http://purl.uniprot.org/uniprot/C0H4F0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/36329:PF3D7_1342000 ^@ http://purl.uniprot.org/uniprot/Q8IDR9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/36329:PF3D7_1470500 ^@ http://purl.uniprot.org/uniprot/Q8IKD3 ^@ Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions.|||Expressed during the asexual blood stage, probably in gametocytes.|||Impaired gametogenesis (PubMed:18452584). Gametocytes are morphologically normal up to and including stage V of development; however, gametocytes fail to round up upon stimulation of gametogenesis with xanthurenic acid and levels of exflagellation are severely reduced (PubMed:18452584). Higher levels of intracellular cGMP in stages III to V gametocytes (PubMed:18452584).|||Membrane|||Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes (PubMed:18452584). Probably by regulating cGMP levels, required for activation of gametogenesis (PubMed:18452584). http://togogenome.org/gene/36329:PF3D7_1407500 ^@ http://purl.uniprot.org/uniprot/Q8IM19 ^@ Similarity ^@ Belongs to the TRM112 family. http://togogenome.org/gene/36329:PF3D7_0209300 ^@ http://purl.uniprot.org/uniprot/P62368 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IspF family.|||Binds 1 divalent metal cation per subunit.|||Homotrimer.|||In the mevalonate-independent isoprenoid biosynthetic pathway, converts 4-diphosphocytidyl-2C-methyl-D-erythritol 2-phosphate into 2C-methyl-D-erythritol 2,4-cyclodiphosphate and CMP.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1306300 ^@ http://purl.uniprot.org/uniprot/C0H5A2 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/36329:PF3D7_1309500 ^@ http://purl.uniprot.org/uniprot/Q8I700 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GAR1 family.|||Component of the small nucleolar ribonucleoprotein particles containing H/ACA-type snoRNAs (H/ACA snoRNPs).|||Required for ribosome biogenesis. Part of a complex which catalyzes pseudouridylation of rRNA. This involves the isomerization of uridine such that the ribose is subsequently attached to C5, instead of the normal N1. Pseudouridine ("psi") residues may serve to stabilize the conformation of rRNAs.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0624700 ^@ http://purl.uniprot.org/uniprot/C6KT83 ^@ Function|||Similarity ^@ Belongs to the PIGL family.|||Involved in the second step of GPI biosynthesis. De-N-acetylation of N-acetylglucosaminyl-phosphatidylinositol. http://togogenome.org/gene/36329:PF3D7_1004800 ^@ http://purl.uniprot.org/uniprot/Q8IJY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1456900 ^@ http://purl.uniprot.org/uniprot/Q8IKR0 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/36329:PF3D7_1345200 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8X1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0603700 ^@ http://purl.uniprot.org/uniprot/C6KSN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/36329:PF3D7_1138500 ^@ http://purl.uniprot.org/uniprot/Q8IHY0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Enzyme with a broad specificity.|||Membrane http://togogenome.org/gene/36329:PF3D7_1135000.1 ^@ http://purl.uniprot.org/uniprot/Q8II14 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0802200 ^@ http://purl.uniprot.org/uniprot/Q8IAM2 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/36329:PF3D7_1225100 ^@ http://purl.uniprot.org/uniprot/Q8I5G6 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1202700 ^@ http://purl.uniprot.org/uniprot/Q8I618 ^@ Similarity ^@ Belongs to the AATF family. http://togogenome.org/gene/36329:PF3D7_1033900 ^@ http://purl.uniprot.org/uniprot/Q8IJ70 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1407900 ^@ http://purl.uniprot.org/uniprot/Q7KQM4 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||During the asexual blood stage, catalyzes the initial cleavage of native host hemoglobin (Hb) resulting in Hb denaturation; specifically cleaves between Phe-33 and Leu-34 of Hb alpha-chain. Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity.|||Expressed during the asexual blood stage including in trophozoites (at protein level).|||Inhibited by KNI derived compounds KNI-10333 and to a lesser extent KNI-10743.|||Membrane|||No growth defect (PubMed:15513918). However, slight decrease in proliferation and slight increase in doubling time during the asexual blood stage in an amino acid-limited medium (PubMed:15513918).|||Not N-glycosylated.|||Proteolytically cleaved into the soluble active mature form in the digestive vacuole by cysteine protease falcipains; the process begins at the early ring stage (PubMed:14709539). Proteolysis requires an acidic environment (By similarity).|||Vacuole lumen|||Vacuole membrane http://togogenome.org/gene/36329:PF3D7_0719300 ^@ http://purl.uniprot.org/uniprot/Q8IBQ9 ^@ Similarity ^@ Belongs to the actin family. ARP6 subfamily. http://togogenome.org/gene/36329:PF3D7_0925400 ^@ http://purl.uniprot.org/uniprot/Q8I2Q4 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_0210600 ^@ http://purl.uniprot.org/uniprot/O96188 ^@ Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Subcellular Location Annotation ^@ Conditional knockout at the ring stage has no effect on parasite development during the first cycle and merozoites egress normally from host erythrocytes. However, these merozoites are unable to reinvade new erythrocytes (PubMed:31492901, PubMed:32179747). Impaired rhoptry secretion during merozoite invasion of host erythrocytes (PubMed:31492901, PubMed:32179747). Increases the spatial segregation between rhoptry neck protein RON4 and bulb protein RAP1, and impairs RAP1 processing (PubMed:32179747). No effect on rhoptry morphology (PubMed:31492901, PubMed:32179747). Microneme secretion is not affected (PubMed:31492901).|||During parasite asexual blood stages, expressed at the late schizont stage and in free merozoites (at protein level).|||Essential for merozoite invasion of host cells by controlling rhoptry secretion (PubMed:31492901, PubMed:32179747). Binds to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2) lipids and thus, likely contributes to the assembly of the machinery that docks or primes the rhoptry to the parasite cell membrane prior to the fusion with the host cell membrane (PubMed:31492901).|||The C2 domain is a non-calcium binding domain (By similarity). Cooperates with the PH domain in the binding to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2) (By similarity).|||The PH domain cooperates with the C2 domain in the binding to phosphatidic acid (PA) and phosphatidylinositol 4,5-bisphosphate (PIP2).|||rhoptry membrane http://togogenome.org/gene/36329:PF3D7_0919200 ^@ http://purl.uniprot.org/uniprot/Q8I2W1 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/36329:PF3D7_1446700 ^@ http://purl.uniprot.org/uniprot/Q8IL06 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0809700 ^@ http://purl.uniprot.org/uniprot/Q8IAT2 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/36329:PF3D7_0715500 ^@ http://purl.uniprot.org/uniprot/Q8IBU5 ^@ Similarity ^@ Belongs to the eukaryotic ATPase epsilon family. http://togogenome.org/gene/36329:PF3D7_0934400 ^@ http://purl.uniprot.org/uniprot/Q8I2H4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0603400 ^@ http://purl.uniprot.org/uniprot/Q6LFN2 ^@ Biotechnology|||Developmental Stage ^@ Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1037100 ^@ http://purl.uniprot.org/uniprot/Q8IJ37 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/36329:PF3D7_0611200 ^@ http://purl.uniprot.org/uniprot/C6KSV7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1142600 ^@ http://purl.uniprot.org/uniprot/Q8IHT9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/36329:PF3D7_1109900 ^@ http://purl.uniprot.org/uniprot/Q8I713 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/36329:PF3D7_1357100 ^@ http://purl.uniprot.org/uniprot/Q8I0P6 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/36329:PF3D7_0409100 ^@ http://purl.uniprot.org/uniprot/C0H4A0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP31 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0925700 ^@ http://purl.uniprot.org/uniprot/Q7K6A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0211500 ^@ http://purl.uniprot.org/uniprot/O96195 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0420400 ^@ http://purl.uniprot.org/uniprot/Q8IFQ7 ^@ Similarity ^@ Belongs to the RRF family. http://togogenome.org/gene/36329:PF3D7_0628300.1 ^@ http://purl.uniprot.org/uniprot/C6KTB9 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/36329:PF3D7_1438900 ^@ http://purl.uniprot.org/uniprot/Q8IL80 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/36329:PF3D7_1435500 ^@ http://purl.uniprot.org/uniprot/Q8ILA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/36329:PF3D7_0308000 ^@ http://purl.uniprot.org/uniprot/O77321 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase delta/II small subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1464700 ^@ http://purl.uniprot.org/uniprot/Q8IKJ0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/36329:PF3D7_1462800 ^@ http://purl.uniprot.org/uniprot/Q8IKK7 ^@ Similarity|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/36329:PF3D7_0520000 ^@ http://purl.uniprot.org/uniprot/Q8I3R0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS4 family. http://togogenome.org/gene/36329:PF3D7_1341200 ^@ http://purl.uniprot.org/uniprot/Q8IDS6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/36329:PF3D7_0415900 ^@ http://purl.uniprot.org/uniprot/C0H4A6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/36329:PF3D7_0423600 ^@ http://purl.uniprot.org/uniprot/Q8IFN0 ^@ Biotechnology|||Developmental Stage|||Subcellular Location Annotation ^@ Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1426000 ^@ http://purl.uniprot.org/uniprot/Q8ILK3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/36329:PF3D7_0921000.1 ^@ http://purl.uniprot.org/uniprot/Q8I2U3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1342700 ^@ http://purl.uniprot.org/uniprot/Q8IDR2 ^@ Similarity ^@ Belongs to the archaeal Rpo12/eukaryotic RPC10 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_1431800 ^@ http://purl.uniprot.org/uniprot/Q8ILE7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/36329:PF3D7_1446800 ^@ http://purl.uniprot.org/uniprot/Q8IL04 ^@ Developmental Stage|||Function|||Miscellaneous|||Subcellular Location Annotation|||Subunit ^@ Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987). Interacts with falcipain 2; the interaction is direct and enhances HDP catalytic activity (PubMed:23471987). Interacts with host hemoglobin (PubMed:28949547).|||Expressed during the asexual blood stage including in trophozoites (at protein level).|||HDP is critical for survival, suggesting it could be a potential malaria drug target.|||Heme detoxifying enzyme that converts heme to crystalline hemozoin (beta-hematin) to protect the organism from the toxic effects of heme (PubMed:18437218, PubMed:23471987, PubMed:25138161, PubMed:28949547). During its development, P.falciparum proteolyzes vast amounts of host hemoglobin, leading to heme release (PubMed:18437218).|||Vacuole|||host cytosol http://togogenome.org/gene/36329:PF3D7_1147700 ^@ http://purl.uniprot.org/uniprot/Q8IHP4 ^@ Similarity ^@ Belongs to the ATPase epsilon chain family. http://togogenome.org/gene/36329:PF3D7_1460700 ^@ http://purl.uniprot.org/uniprot/Q8IKM5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL27 family. http://togogenome.org/gene/36329:PF3D7_1324800 ^@ http://purl.uniprot.org/uniprot/Q8IE69 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/36329:PF3D7_0708400 ^@ http://purl.uniprot.org/uniprot/Q8IC05 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/36329:PF3D7_1417600 ^@ http://purl.uniprot.org/uniprot/Q8ILR9 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0708300 ^@ http://purl.uniprot.org/uniprot/Q8IC06 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/36329:PF3D7_1141400 ^@ http://purl.uniprot.org/uniprot/Q8IHV1 ^@ Similarity ^@ Belongs to the PIGH family. http://togogenome.org/gene/36329:PF3D7_1016300 ^@ http://purl.uniprot.org/uniprot/Q8I6U8 ^@ Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ Cell surface|||Host cytoplasm|||Interacts with host glycophorin.|||Involved in merozoite invasion of host erythrocytes.|||Secreted|||The PEXEL motif is involved in the protein translocation through the parasitophorous vacuole membrane and into the host erythrocyte cytoplasm. http://togogenome.org/gene/36329:PF3D7_1128700 ^@ http://purl.uniprot.org/uniprot/Q8II76 ^@ Function|||Similarity ^@ Belongs to the peptidase C13 family.|||Mediates GPI anchoring in the endoplasmic reticulum, by replacing a protein's C-terminal GPI attachment signal peptide with a pre-assembled GPI. During this transamidation reaction, the GPI transamidase forms a carbonyl intermediate with the substrate protein. http://togogenome.org/gene/36329:PF3D7_1438000 ^@ http://purl.uniprot.org/uniprot/Q8IL87 ^@ Function|||Similarity ^@ Belongs to the WD repeat EIF2A family.|||Functions in the early steps of protein synthesis of a small number of specific mRNAs. Acts by directing the binding of methionyl-tRNAi to 40S ribosomal subunits. In contrast to the eIF-2 complex, it binds methionyl-tRNAi to 40S subunits in a codon-dependent manner, whereas the eIF-2 complex binds methionyl-tRNAi to 40S subunits in a GTP-dependent manner. http://togogenome.org/gene/36329:PF3D7_1223600 ^@ http://purl.uniprot.org/uniprot/Q8I5I1 ^@ Biotechnology|||Developmental Stage|||Subcellular Location Annotation ^@ Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0518400 ^@ http://purl.uniprot.org/uniprot/Q7K6A7 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/36329:PF3D7_0915400 ^@ http://purl.uniprot.org/uniprot/Q8I2Z8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphofructokinase type A (PFKA) family. PPi-dependent PFK group II subfamily. Clade 'Long' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Tetramer of two alpha (regulatory) and two beta (catalytic) chains. http://togogenome.org/gene/36329:PF3D7_0924000 ^@ http://purl.uniprot.org/uniprot/Q8I2R7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_1315600 ^@ http://purl.uniprot.org/uniprot/C0H5B7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1472900 ^@ http://purl.uniprot.org/uniprot/Q8IKA9 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class II DHOase subfamily. http://togogenome.org/gene/36329:PF3D7_1205700 ^@ http://purl.uniprot.org/uniprot/Q8I5Y8 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/36329:PF3D7_1407100 ^@ http://purl.uniprot.org/uniprot/Q8IM23 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Fibrillarin family. http://togogenome.org/gene/36329:PF3D7_1355800 ^@ http://purl.uniprot.org/uniprot/C0H5I5 ^@ Similarity ^@ Belongs to the SF3B5 family. http://togogenome.org/gene/36329:PF3D7_1440200 ^@ http://purl.uniprot.org/uniprot/Q8IL68 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ALAD family.|||Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen.|||Homooctamer. http://togogenome.org/gene/36329:PF3D7_1461900 ^@ http://purl.uniprot.org/uniprot/Q8IKL5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0911400 ^@ http://purl.uniprot.org/uniprot/Q8I338 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAK10 family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1124000 ^@ http://purl.uniprot.org/uniprot/Q8IIC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/36329:PF3D7_1209500.1 ^@ http://purl.uniprot.org/uniprot/Q8I5V4 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 1 Mg(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium (By similarity). Binds magnesium less tightly than zinc (By similarity).|||Binds 1 Zn(2+) ion per subunit. Binds 2 divalent metal cations per subunit: site 1 preferentially binds zinc, while site 2 has a preference for magnesium (By similarity). Tightly binds zinc (By similarity).|||Expressed at the ring stage during the asexual blood stage.|||Knockouts at the asexual blood stage are viable and have normal merozoite formation in the host erythrocytes (PubMed:18590734). cGMP hydrolysis is reduced by about 20% with no effect on cAMP hydrolysis (PubMed:18590734).|||Membrane|||Not inhibited by cAMP (PubMed:18590734). Inhibited by zaprinast (PubMed:16038615, PubMed:18590734).|||Specifically hydrolyzes the second messenger cGMP, which is a key regulator of many important physiological processes. http://togogenome.org/gene/36329:PF3D7_1466100 ^@ http://purl.uniprot.org/uniprot/Q8IKH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. BSU subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1328800 ^@ http://purl.uniprot.org/uniprot/Q8IE47 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level) (PubMed:18397290, PubMed:22379140). Not detected at the ring stage (PubMed:18397290).|||Homotrimer. Dissociates into monomers on binding NAD.|||Inhibited by nicotinamide. Inhibited by surfactin, which is a competitive inhibitor of NAD and an uncompetitive inhibitor of acetylated peptide.|||Loss of binding to telomers and subtelomeric repeat regions (TAREs) and promoters of var genes.|||NAD-dependent protein deacylase (PubMed:21992006). Catalyzes the NAD-dependent hydrolysis of medium and long chain fatty acyl groups from lysine residues (PubMed:21992006). Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo (PubMed:17827348, PubMed:18729382, PubMed:18397290, PubMed:18221799, PubMed:20601220, PubMed:21992006). Regulates the expression of the surface antigen-coding var genes central to the malaria pathogenesis (PubMed:15820676, PubMed:22379140). Cooperates with Sir2B to mediate silencing and mutual exclusive expression of only 1 of the 60 subtelomeric var genes at a time, coding for functionally different but epitopically variant versions of the erythrocyte membrane protein 1 (PfEMP1) molecule, to evade the detection by host immune surveillance (PubMed:19402747). Involved in recruiting ORC1 to the telomers and subtelomeric repeat regions (TAREs) and promoters of var genes (PubMed:22379140). Can ADP-ribosylate both histones and itself (PubMed:17827348). May also have a role in telomeric end protection (PubMed:18525026).|||Nucleus|||The reported ADP-ribosyltransferase activity of sirtuins is likely to be some inefficient side reaction of the deacetylase activity and may not be physiologically relevant.|||nucleolus|||telomere http://togogenome.org/gene/36329:PF3D7_0807900 ^@ http://purl.uniprot.org/uniprot/Q8IAR7 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0219500 ^@ http://purl.uniprot.org/uniprot/O96270 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/36329:PF3D7_0727500 ^@ http://purl.uniprot.org/uniprot/Q8IBI2 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/36329:PF3D7_1146600 ^@ http://purl.uniprot.org/uniprot/Q8IHQ2 ^@ Similarity ^@ Belongs to the NFYB/HAP3 subunit family. http://togogenome.org/gene/36329:PF3D7_1342100 ^@ http://purl.uniprot.org/uniprot/Q8IDR8 ^@ Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/36329:PF3D7_0721600 ^@ http://purl.uniprot.org/uniprot/Q8IBN5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/36329:PF3D7_1315700 ^@ http://purl.uniprot.org/uniprot/Q8IEF7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family. http://togogenome.org/gene/36329:PF3D7_0610400 ^@ http://purl.uniprot.org/uniprot/C6KSV0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_1347100 ^@ http://purl.uniprot.org/uniprot/Q8IDM7 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/36329:PF3D7_0628200 ^@ http://purl.uniprot.org/uniprot/C6KTB8 ^@ Activity Regulation|||Caution|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auto-phosphorylated.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. GCN2 subfamily.|||Dissociation from BIP and oligomerization, may results autophosphorylation and kinase activity induction.|||During the asexual blood stage, phosphorylates translation factor eIF2alpha in late schizonts resulting in protein translation inhibition (PubMed:22355110, PubMed:29241041). Plays a role in trophozoite differentiation into schizonts (PubMed:29241041).|||Endoplasmic reticulum membrane|||Expressed during the asexual blood stage (at protein level).|||May form oligomers in response to stress; oligomerization may result in catalytic activity (PubMed:29241041). Interacts with BIP; the interaction is disrupted in response to stress (By similarity).|||Smaller forms of 80-90kDa appear to be present in the asexual blood stage suggesting that the protein may be proteolytically cleaved (By similarity). They localize to the cytoplasm in schizonts, to organelles in all blood stages and to the host erythrocyte membrane during schizont segmentation (By similarity). http://togogenome.org/gene/36329:PF3D7_0604200 ^@ http://purl.uniprot.org/uniprot/C6KSP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_0612900 ^@ http://purl.uniprot.org/uniprot/C6KSX2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. NOG subfamily.|||Involved in the biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1223300 ^@ http://purl.uniprot.org/uniprot/Q8I0X3 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/36329:PF3D7_0203300 ^@ http://purl.uniprot.org/uniprot/O96136 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERCC1/RAD10/SWI10 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1423300 ^@ http://purl.uniprot.org/uniprot/Q8ILL9 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_1332800 ^@ http://purl.uniprot.org/uniprot/Q8IE00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-6 family.|||Binds to the 60S ribosomal subunit and prevents its association with the 40S ribosomal subunit to form the 80S initiation complex in the cytoplasm. May also be involved in ribosome biogenesis.|||Cytoplasm|||Monomer. Associates with the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1438600 ^@ http://purl.uniprot.org/uniprot/Q8IL82 ^@ Similarity ^@ Belongs to the GET4 family. http://togogenome.org/gene/36329:PF3D7_0905900 ^@ http://purl.uniprot.org/uniprot/Q8I390 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/36329:PF3D7_0606700 ^@ http://purl.uniprot.org/uniprot/C6KSR5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1425700 ^@ http://purl.uniprot.org/uniprot/Q8ILK6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0525100 ^@ http://purl.uniprot.org/uniprot/Q8I3L4 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/36329:PF3D7_1224500 ^@ http://purl.uniprot.org/uniprot/Q8I5H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1307600 ^@ http://purl.uniprot.org/uniprot/Q8IEN9 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/36329:PF3D7_1125300 ^@ http://purl.uniprot.org/uniprot/Q8IIB0 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/36329:PF3D7_1032800 ^@ http://purl.uniprot.org/uniprot/C6S3E1 ^@ Similarity ^@ Belongs to the SDS22 family. http://togogenome.org/gene/36329:PF3D7_1206600 ^@ http://purl.uniprot.org/uniprot/Q8I5X9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||apicoplast http://togogenome.org/gene/36329:PF3D7_0907400 ^@ http://purl.uniprot.org/uniprot/Q8I377 ^@ Similarity ^@ Belongs to the ClpX chaperone family. HslU subfamily. http://togogenome.org/gene/36329:PF3D7_1008900 ^@ http://purl.uniprot.org/uniprot/Q8IJV6 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:15478799). Has very low activity with CTP, GTP, ITP and UTP and no activity with GMP, CMP, UMP or IMP in vitro (PubMed:15478799).|||Cytoplasm|||Inhibited by the dinucleoside pentaphosphate compound P1,P5-di(adenosine-5') pentaphosphate (AP5A). http://togogenome.org/gene/36329:PF3D7_0507400 ^@ http://purl.uniprot.org/uniprot/C0H4D0 ^@ Developmental Stage|||Function|||Subcellular Location Annotation ^@ Acts as a specific inhibitor of subtilisin-like protease SUB1.|||Cell membrane|||Expressed during the parasite blood stage, specifically in schizonts (at protein level).|||Parasitophorous vacuole lumen|||Secreted http://togogenome.org/gene/36329:PF3D7_1139700 ^@ http://purl.uniprot.org/uniprot/Q8IHW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1235000 ^@ http://purl.uniprot.org/uniprot/Q8I572 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/36329:PF3D7_1213800 ^@ http://purl.uniprot.org/uniprot/Q8I5R7 ^@ Activity Regulation|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro) (PubMed:25817387, PubMed:27798837). Functions in trans to edit the amino acid moiety from incorrectly charged Ala-tRNA(Pro) (PubMed:14663147). Has no activity on correctly charged Pro-tRNA(Pro) or Ala-tRNA(Ala) (PubMed:14663147).|||Consists of four domains: the N-terminal editing domain, the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension (Probable). The first domain (about residues 1-163) is required for editing of incorrectly charged tRNA (PubMed:14663147). When it is deleted the enzyme shows pronounced misacylation of tRNA(Pro) with alanine (PubMed:14663147).|||Cytoplasm|||Expressed during the asexual blood stage including at the ring stage and in trophozoites and schizonts (at protein level).|||Homodimer.|||Inhibited by the quinazolinone-based compound febrifugine from the Chinese plant Dichroa febrifuga which is used to treat malaria-associated fever (PubMed:25817387, PubMed:27798837). Also inhibited by febrifugine derivatives such as halofuginone (PubMed:25817387, PubMed:27798837). http://togogenome.org/gene/36329:PF3D7_1115400 ^@ http://purl.uniprot.org/uniprot/Q8IIL0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_0203000 ^@ http://purl.uniprot.org/uniprot/O96133 ^@ Biotechnology|||Developmental Stage|||Subcellular Location Annotation ^@ Expressed during the asexual blood stage.|||Host cell membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0509500 ^@ http://purl.uniprot.org/uniprot/Q8I409 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/36329:PF3D7_0322000 ^@ http://purl.uniprot.org/uniprot/Q76NN7 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_1110900 ^@ http://purl.uniprot.org/uniprot/Q8IIQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1366500 ^@ http://purl.uniprot.org/uniprot/Q8ID43 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/36329:PF3D7_1422000 ^@ http://purl.uniprot.org/uniprot/C6S3H9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0932400 ^@ http://purl.uniprot.org/uniprot/Q8I2J2 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/36329:PF3D7_1353600 ^@ http://purl.uniprot.org/uniprot/Q76NM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Required for the retention of luminal endoplasmic reticulum proteins. Determines the specificity of the luminal ER protein retention system. Also required for normal vesicular traffic through the Golgi (By similarity). http://togogenome.org/gene/36329:PF3D7_0921400 ^@ http://purl.uniprot.org/uniprot/Q8I2T9 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/36329:PF3D7_0615300 ^@ http://purl.uniprot.org/uniprot/C6KSZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0113300 ^@ http://purl.uniprot.org/uniprot/Q9U0M8 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0529000 ^@ http://purl.uniprot.org/uniprot/Q8I3H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TIP family.|||May protect the parasite against attack by the host immune system by immunomodulation.|||Membrane http://togogenome.org/gene/36329:PF3D7_0308200 ^@ http://purl.uniprot.org/uniprot/O77323 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm|||Heterooligomeric complex of about 850 to 900 kDa that forms two stacked rings, 12 to 16 nm in diameter.|||Molecular chaperone; assists the folding of proteins upon ATP hydrolysis. Known to play a role, in vitro, in the folding of actin and tubulin (By similarity). http://togogenome.org/gene/36329:PF3D7_1026400 ^@ http://purl.uniprot.org/uniprot/Q8IJD7 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/36329:PF3D7_0809500 ^@ http://purl.uniprot.org/uniprot/C0H4T2 ^@ Similarity ^@ Belongs to the EAF6 family. http://togogenome.org/gene/36329:PF3D7_0204400 ^@ http://purl.uniprot.org/uniprot/C6S3A9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1140500 ^@ http://purl.uniprot.org/uniprot/Q8IHW0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/36329:PF3D7_0626300 ^@ http://purl.uniprot.org/uniprot/C6KT99 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/36329:PF3D7_0923800.1 ^@ http://purl.uniprot.org/uniprot/P61076 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Catalyzes the transfer of electrons from NADPH to thioredoxins TRX1, TRX2 and TRX3, which in turn act as reductants of disulfide containing proteins (PubMed:9368022, PubMed:11013257, PubMed:16910770, PubMed:23845423). Able to reduce nitroglutathione (GSNO), a compound involved in the transport of nitric oxide (NO); however, TRX1 is more efficient in reducing GSNO (PubMed:11013257). Has no catalytic activity towards oxidized glutathione (GSSG) (PubMed:11013257).|||Cytoplasm|||Homodimer.|||In Plasmodium, the C-terminal redox center, which acts as the active site, is formed by two cysteines while in mammalian TRXR this redox center is composed of a cysteine-selenocysteine active site.|||Mitochondrion|||Produced by alternative initiation at Met-77 of isoform 1. http://togogenome.org/gene/36329:PF3D7_1037300 ^@ http://purl.uniprot.org/uniprot/Q8IJ34 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Catalyzes the exchange of ADP and ATP across the membrane.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. http://togogenome.org/gene/36329:PF3D7_0935200 ^@ http://purl.uniprot.org/uniprot/Q8I2G8 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/36329:PF3D7_1224600 ^@ http://purl.uniprot.org/uniprot/Q8I5H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1133800 ^@ http://purl.uniprot.org/uniprot/Q8II27 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0309600 ^@ http://purl.uniprot.org/uniprot/O00806 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||P1 and P2 exist as dimers at the large ribosomal subunit.|||Phosphorylated.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/36329:PF3D7_1235800 ^@ http://purl.uniprot.org/uniprot/Q8I565 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/36329:PF3D7_1310600 ^@ http://purl.uniprot.org/uniprot/Q76NM7 ^@ Activity Regulation|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Alternates between an inactive GDP-bound form and an active GTP-bound form (By similarity). Activated by guanine nucleotide-exchange factors (GEFs) and inactivated by GTPase-activating proteins (GAPs) (By similarity).|||Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Expressed during the asexual blood stage, including the trophozoite and schizont stages (at protein level).|||Interacts with CK1 (PubMed:22188458). May interact with ARF1 (PubMed:33604307).|||Lacks the C-terminal cysteine motifs subject to isoprenylation present in mammalian RAB5B homolog.|||May be palmitoylated on Cys-3.|||Myristoylation is required for cell membrane and food vacuole membrane localization.|||Small GTPase which regulates vesicle trafficking between organelles (Probable). May be involved in the trafficking of the N-myristoylated AK2 from the endoplasmic reticulum to the parasitophorous vacuole membrane (PubMed:27316546).|||Vacuole membrane|||Vesicle http://togogenome.org/gene/36329:PF3D7_1327800 ^@ http://purl.uniprot.org/uniprot/Q8IE40 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/36329:PF3D7_0910600 ^@ http://purl.uniprot.org/uniprot/Q8I346 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/36329:PF3D7_1453300 ^@ http://purl.uniprot.org/uniprot/C6S3J4 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/36329:PF3D7_0209400 ^@ http://purl.uniprot.org/uniprot/C6S3B4 ^@ Domain|||Function|||Similarity ^@ Belongs to the damage-control phosphatase family. Sugar phosphate phosphatase III subfamily.|||Metal-dependent phosphatase that shows phosphatase activity against several substrates, including fructose-1-phosphate and fructose-6-phosphate. Its preference for fructose-1-phosphate, a strong glycating agent that causes DNA damage rather than a canonical yeast metabolite, suggests a damage-control function in hexose phosphate metabolism.|||Subfamily III proteins have a conserved RTxK motif about 40-50 residues from the C-terminus; the threonine may be replaced by serine or cysteine. http://togogenome.org/gene/36329:PF3D7_1130000 ^@ http://purl.uniprot.org/uniprot/Q8II63 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/36329:PF3D7_0527300 ^@ http://purl.uniprot.org/uniprot/Q8I3J2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/36329:PF3D7_0705100 ^@ http://purl.uniprot.org/uniprot/Q8IC19 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1203000 ^@ http://purl.uniprot.org/uniprot/Q8I615 ^@ Biotechnology|||Developmental Stage|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC1 family.|||Component of the origin recognition complex (ORC) (By similarity). Interacts (via PIP-box) with PCNA1; the interaction occurs during DNA replication in trophozoites (PubMed:18554328, PubMed:19633266).|||Component of the origin recognition complex (ORC) that binds origins of replication and thus may regulate the initiation of DNA replication (Probable). DNA-binding may not be ATP-dependent (PubMed:19633266). In a SIR2A/Sir2-dependent manner, binds to and silences telomers and subtelomeric repeat regions (TAREs) (PubMed:18525026, PubMed:22379140, PubMed:24018145). In a SIR2A/Sir2-dependent manner, binds to promoters of var genes localized next to TAREs resulting in their silencing (PubMed:22379140).|||Expressed during the asexual blood stage, specifically during the late trophozoite and early schizont stages (at protein level) (PubMed:16216221, PubMed:18525026, PubMed:18554328, PubMed:19633266, PubMed:22379140, PubMed:26094711). Some expression has been found also at the ring stage (at protein level) (PubMed:18525026, PubMed:18554328, PubMed:22379140, PubMed:26094711). Highly expressed during the sexual blood stage (PubMed:12543146).|||In schizonts, may be phosphorylated by PK5; phosphorylation leads to ORC1 dissociation from the telomeres and var gene promoters, translocation to the cytoplasm, where it is degraded by the proteasome.|||Leucine heptad repeats are essential for the binding to telomeric DNA.|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||The C-terminal domain binds ATP and is required for the binding to DNA replication origin sites.|||The N-terminal domain binds telomeric DNA and is required for the silencing of telomers and var genes.|||nucleolus|||telomere http://togogenome.org/gene/36329:PF3D7_1356200 ^@ http://purl.uniprot.org/uniprot/Q8IDE0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1438400 ^@ http://purl.uniprot.org/uniprot/Q8IL84 ^@ Activity Regulation|||Caution|||Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C14B family.|||Ca(2+) does not appear to affect catalytic activity.|||Cytoplasm|||Expressed during the parasite blood stage, specifically in schizonts, and gametocytes (at protein level).|||In contrast to other metacaspases of the peptidase C14B family, the catalytic histidine and cysteine residues do not appear to be conserved.|||Protease that cleaves specifically after arginine or lysine residues (PubMed:29317266, PubMed:32202613). May play a role in parasite growth and/or development (PubMed:29317266, PubMed:32202613).|||Up-regulated by oxidative stress. http://togogenome.org/gene/36329:PF3D7_0320900 ^@ http://purl.uniprot.org/uniprot/O97320 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_0310000 ^@ http://purl.uniprot.org/uniprot/Q9NLA7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family. http://togogenome.org/gene/36329:PF3D7_0513400 ^@ http://purl.uniprot.org/uniprot/C0H4D6 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/36329:PF3D7_1125400 ^@ http://purl.uniprot.org/uniprot/Q8IIA9 ^@ Similarity ^@ Belongs to the Tim44 family. http://togogenome.org/gene/36329:PF3D7_0918100 ^@ http://purl.uniprot.org/uniprot/C0H542 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/36329:PF3D7_0802300 ^@ http://purl.uniprot.org/uniprot/Q8IAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1203700 ^@ http://purl.uniprot.org/uniprot/Q8I608 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/36329:PF3D7_0307500 ^@ http://purl.uniprot.org/uniprot/O97253 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/36329:PF3D7_1345900 ^@ http://purl.uniprot.org/uniprot/A0A5K1K999 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/36329:PF3D7_1139500.1 ^@ http://purl.uniprot.org/uniprot/Q8IHX1 ^@ Similarity ^@ Belongs to the AAA ATPase family. PCH2 subfamily. http://togogenome.org/gene/36329:PF3D7_1463300 ^@ http://purl.uniprot.org/uniprot/Q8IKK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase alpha subunit B family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1432700 ^@ http://purl.uniprot.org/uniprot/A0A144A3E6 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/36329:PF3D7_1219600 ^@ http://purl.uniprot.org/uniprot/Q8I5L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/36329:PF3D7_1225500 ^@ http://purl.uniprot.org/uniprot/Q8I5G2 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/36329:PF3D7_0613300 ^@ http://purl.uniprot.org/uniprot/C6KSX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lipase maturation factor family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0815900 ^@ http://purl.uniprot.org/uniprot/Q8IAZ6 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/36329:PF3D7_1340800 ^@ http://purl.uniprot.org/uniprot/Q8IDS8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial pyruvate carrier (MPC) (TC 2.A.105) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the uptake of pyruvate into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0528500 ^@ http://purl.uniprot.org/uniprot/Q8I3I2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/36329:PF3D7_0919000 ^@ http://purl.uniprot.org/uniprot/Q8I2W3 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/36329:PF3D7_1439700 ^@ http://purl.uniprot.org/uniprot/Q8IL72 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. LCMT family.|||Methylates the carboxyl group of the C-terminal leucine residue of protein phosphatase 2A catalytic subunits to form alpha-leucine ester residues. http://togogenome.org/gene/36329:PF3D7_1315100 ^@ http://purl.uniprot.org/uniprot/Q8IEG4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_1239500 ^@ http://purl.uniprot.org/uniprot/Q8I528 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_0828000 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8S0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/36329:PF3D7_1132600 ^@ http://purl.uniprot.org/uniprot/Q8II38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus|||Required for pre-mRNA splicing. http://togogenome.org/gene/36329:PF3D7_0318100 ^@ http://purl.uniprot.org/uniprot/O77376 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/36329:PF3D7_0315100 ^@ http://purl.uniprot.org/uniprot/O97266 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/36329:PF3D7_1362100 ^@ http://purl.uniprot.org/uniprot/A0A5K1K948 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/36329:PF3D7_0602500 ^@ http://purl.uniprot.org/uniprot/C6KSM5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit beta family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a geranylgeranyl moiety from geranylgeranyl diphosphate to both cysteines of proteins with the C-terminal sequence -XXCC, -XCXC and -CCXX. http://togogenome.org/gene/36329:PF3D7_1420000 ^@ http://purl.uniprot.org/uniprot/Q8ILQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B4 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0320800 ^@ http://purl.uniprot.org/uniprot/O97285 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_0113900 ^@ http://purl.uniprot.org/uniprot/Q8I2D9 ^@ Biotechnology|||Developmental Stage|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ By binding to host chemokine CX3CL1, mediates the cytoadherence of host erythrocytes infected with parasite mature forms (late trophozoite and schizont) to endothelial cells, which sequesters them away from the circulation and thus prevents their elimination by the host spleen.|||Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:32184257). Expressed in gametocytes from stages I to IV (at protein level) (PubMed:27653778, PubMed:20332084).|||Host cell membrane|||Host cytoplasmic vesicle membrane|||Monomer (PubMed:27653778). May form homodimers or homotrimers (PubMed:27653778). Interacts with MAHRP1 (PubMed:32184257). Interacts (via extracellular domain) with human chemokine CX3CL1; the interaction mediates the adhesion of infected erythrocytes with endothelial cells (PubMed:27653778).|||Potential vaccine candidate as CBP1-based peptides or antibodies against CBP1 prevents adhesion of infected erythrocytes to endothelial cells.|||The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (PubMed:20332084). http://togogenome.org/gene/36329:PF3D7_0625600 ^@ http://purl.uniprot.org/uniprot/C6KT92 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/36329:PF3D7_0821700 ^@ http://purl.uniprot.org/uniprot/Q8IB51 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL22 family. http://togogenome.org/gene/36329:PF3D7_1232400 ^@ http://purl.uniprot.org/uniprot/Q8I598 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/36329:PF3D7_1202200 ^@ http://purl.uniprot.org/uniprot/Q8I623 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0908800 ^@ http://purl.uniprot.org/uniprot/Q8I364 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1446400 ^@ http://purl.uniprot.org/uniprot/Q8IL09 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO2. http://togogenome.org/gene/36329:PF3D7_1317100 ^@ http://purl.uniprot.org/uniprot/Q8IEE5 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/36329:PF3D7_1465900 ^@ http://purl.uniprot.org/uniprot/Q8IKH8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS3 family. http://togogenome.org/gene/36329:PF3D7_0207400 ^@ http://purl.uniprot.org/uniprot/O96163 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_1318400 ^@ http://purl.uniprot.org/uniprot/Q8IED2 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||May play a role in the conversion of interphase chromatin into condensed chromosomes.|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||The SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterodimerization with smc4 forming a V-shaped heterodimer. http://togogenome.org/gene/36329:PF3D7_0418700 ^@ http://purl.uniprot.org/uniprot/Q8I1Q0 ^@ Similarity ^@ Belongs to the NOB1 family. http://togogenome.org/gene/36329:PF3D7_1416500 ^@ http://purl.uniprot.org/uniprot/Q8ILT0 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/36329:PF3D7_1315800 ^@ http://purl.uniprot.org/uniprot/Q8IEF6 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Expressed throughout the erythrocytic development of the infected host, low expression in rings and schizonts, high levels in trophozoites.|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Transcriptional activator. Has a role in the parasite erythrocytic cycle where it directly regulates key genes involved in cell cycle regulation and progression. Binds directly to Myb regulatory elements.|||dsRNA causes reduced expression, alters parasite growth and trophozoite to schizont transition during the erythrocytic cycle. http://togogenome.org/gene/36329:PF3D7_0616000 ^@ http://purl.uniprot.org/uniprot/C6KT01 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/36329:PF3D7_1141600 ^@ http://purl.uniprot.org/uniprot/Q8IHU9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins. http://togogenome.org/gene/36329:PF3D7_1114700 ^@ http://purl.uniprot.org/uniprot/Q8IIL5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. http://togogenome.org/gene/36329:PF3D7_0933800 ^@ http://purl.uniprot.org/uniprot/Q8I2I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin family.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/36329:PF3D7_0402300 ^@ http://purl.uniprot.org/uniprot/P86148 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||During the asexual blood stage, binds to a sialic acid containing receptor on the surface of the host erythrocyte and thus is involved in merozoite invasion (PubMed:18617995). Binds erythrocytes via a neuraminidase sensitive and trypsin-, chymotrypsin-resistant receptor (PubMed:11733572, PubMed:18617995). After merozoite attachment and reorientation, RH1 binding to its erythrocyte receptor triggers an increase in intracellular Ca(2+) within the parasite resulting in the release of microneme proteins such as EBA175 which in turn leads to the formation of the tight junction between parasite and host cell (PubMed:24280897).|||Expressed during parasite asexual blood stages, specifically at the late schizont stage prior to merozoite release and in free merozoites (at protein level) (PubMed:11733572, PubMed:12228308, PubMed:15612925). Expression levels are low in isolate 3D7 when compared to other isolates (at protein level) (PubMed:12228308, PubMed:15612925, PubMed:18617995).|||May in part interact with AMA1 in the moving tight junction between the parasite and the erythrocyte membranes; the interaction may facilitate junction formation and active invasion.|||No difference in the ability to invade neuraminidase-, trypsin or chymotrypsin-treated host erythrocytes compared with wild-type.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera (PubMed:17653272). Antibodies against the erythrocyte binding domain (EBD) prevent merozoite invasion of host erythrocytes (PubMed:18617995, PubMed:24280897). However, inhibition efficiency varies across isolates due to the variation in RH1 expression levels and can also be affected by the expression levels of RH2a and/or RH2b, two other erythrocyte binding receptors (PubMed:18617995). Isolates 3D7 or HB3 are insensitive to antibodies against EBD while isolates W2mef, T994, FCR3 and Dd2 are sensitive (PubMed:18617995, PubMed:24280897).|||Proteolytically processed into multiple fragments following schizont rupture (PubMed:19614665, PubMed:32452132). In the mature schizont stage prior to merozoite release, full length RH1 is processed post-Golgi into a 240 kDa N-terminal form and a 120 kDa C-terminal form containing the transmembrane region (PubMed:12228308, PubMed:15612925, PubMed:19614665, PubMed:32452132). Both forms appear not to form a complex (PubMed:19614665). However, they appear to remain in close proximity in late schizonts (PubMed:32452132). Following merozoite invasion of host erythrocytes, the 240 kDa form is further processed into a 140 kDa form which may be involved in the disengagement of the ligand-receptor complex required during the invasion process (PubMed:19614665, PubMed:32452132). Also, the 120 kDa is further cleaved into a 110 kDa form and a transmembrane 9 kDa form probably by ROM4 (PubMed:17040128, PubMed:19614665, PubMed:32452132).|||RH1 expression levels greatly vary between isolates in part due to multiple RH1 gene copies; levels are high in isolates W2mef, FCR3, FCB1 and T994, and low in isolates 3D7, HB3, K1, 7G8, T996 and Dd2 (PubMed:12228308, PubMed:15612925, PubMed:18617995). A similar variation in expression affects other reticulocyte-binding proteins such as RH2a and RH2b (PubMed:12228308). The expression pattern of RH1 and RH2 allows the strain to use different invasion pathways to enter erythrocytes (Probable). This provides a mechanism of phenotypic variation to evade host immune responses and to adapt to the polymorphic nature of the erythrocyte receptors in human populations (Probable).|||Secreted|||rhoptry|||tight junction http://togogenome.org/gene/36329:PF3D7_1353400 ^@ http://purl.uniprot.org/uniprot/Q8IDG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1137100 ^@ http://purl.uniprot.org/uniprot/Q8IHZ4 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/36329:PF3D7_0607400 ^@ http://purl.uniprot.org/uniprot/C6KSS2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYG1 (TC 2.A.94) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0216400 ^@ http://purl.uniprot.org/uniprot/O96243 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/36329:PF3D7_1203900 ^@ http://purl.uniprot.org/uniprot/Q8I607 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1336900 ^@ http://purl.uniprot.org/uniprot/Q8IDW3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1430200 ^@ http://purl.uniprot.org/uniprot/Q8ILG2 ^@ Activity Regulation|||Caution|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autocleaved into a p55 mature form.|||Belongs to the peptidase A1 family.|||During the asexual blood stage, initiates the proteolytic maturation of several rhoptry proteins and thus, is required for merozoite invasion of host erythrocytes and probably the subsequent development of the ring-stage (PubMed:29074775, PubMed:32109369). Cleaves rhoptry associated protein 1 RAP1 and apical sushi protein ASP during schizont maturation (PubMed:29074775, PubMed:32109369). Also cleaves rhoptry protein RON3 (PubMed:32109369).|||Expressed during the asexual blood stage, in schizonts and free merozoites (at protein level).|||Inhibited by small molecule 49c (PubMed:29074775). Inhibited by small molecule WM382 (PubMed:32109369).|||It is unclear if PMIX is glycosylated as other members of the same enzyme family, i.e. PMI and PMII, are not.|||Membrane|||Normal asexual development in host erythrocytes (PubMed:29074775). Egress from erythrocytes is normal; however, subsequent erythrocyte invasion by newly released merozoites is severely impaired (PubMed:29074775). Accumulation of RAP1 p86 precursor resulting from impaired processing (PubMed:29074775). Impaired ASP processing (PubMed:29074775). Impaired secretion of CyRPA during merozoite egress from erythrocytes (PubMed:29074775).|||rhoptry http://togogenome.org/gene/36329:PF3D7_1346100 ^@ http://purl.uniprot.org/uniprot/Q8IDN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1330600 ^@ http://purl.uniprot.org/uniprot/Q8IE20 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/36329:PF3D7_0934500 ^@ http://purl.uniprot.org/uniprot/Q8I2H3 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/36329:PF3D7_1036800 ^@ http://purl.uniprot.org/uniprot/Q8IJ40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0920100 ^@ http://purl.uniprot.org/uniprot/C0H546 ^@ Similarity ^@ Belongs to the HscB family. http://togogenome.org/gene/36329:PF3D7_1408600 ^@ http://purl.uniprot.org/uniprot/Q8IM10 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/36329:PF3D7_0729200 ^@ http://purl.uniprot.org/uniprot/Q5MYR6 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family. Prx5 subfamily.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/36329:PF3D7_0219200 ^@ http://purl.uniprot.org/uniprot/O96269 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS30 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).|||Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_1010000 ^@ http://purl.uniprot.org/uniprot/Q8IJU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1120000 ^@ http://purl.uniprot.org/uniprot/Q8IIG7 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1365700 ^@ http://purl.uniprot.org/uniprot/Q8ID52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1419800.1 ^@ http://purl.uniprot.org/uniprot/O15770 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Cytoplasm|||Homodimer.|||Maintains high levels of reduced glutathione in the cytosol.|||Produced by alternative initiation at Met-47 of isoform 2.|||The active site is a redox-active disulfide bond.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1450900 ^@ http://purl.uniprot.org/uniprot/Q8IKW7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/36329:PF3D7_1247900 ^@ http://purl.uniprot.org/uniprot/Q8I4V5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UTP11 family.|||Component of the ribosomal small subunit (SSU) processome.|||Involved in nucleolar processing of pre-18S ribosomal RNA.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1324500 ^@ http://purl.uniprot.org/uniprot/Q8IE72 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. DDX11/CHL1 sub-subfamily. http://togogenome.org/gene/36329:PF3D7_1018800 ^@ http://purl.uniprot.org/uniprot/Q8IJL4 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/36329:PF3D7_1246200 ^@ http://purl.uniprot.org/uniprot/Q8I4X0 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A potassium ion appears to reside in the active site during hydrolysis and leaves together with the inorganic phosphate Pi. K(+) does not activate Pi release; however, it may be relevant for ATP hydrolysis.|||ACT1 and ACT2 differ in their polymerization, filament stability and helical structure (PubMed:24743229). Unlike mammalian actin, Apicomplexa actins do not form long and stable filaments (PubMed:24743229).|||ATP hydrolysis occurs in the polymeric state (PubMed:24743229). Unlike for mammalian actin, ATP hydrolysis occurs also in the monomeric form and the release of inorganic phosphate (Pi) is more efficient (PubMed:24743229).|||Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm (PubMed:24743229, PubMed:28923924, PubMed:31199804). Polymerizes into shorter and less stable actin filaments compared to ACT2/actin-2; this is thought to facilitate gliding motility and host cell invasion (PubMed:24743229, PubMed:28923924). Has ATPase activity (PubMed:24743229, PubMed:31199804). ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi (Probable). ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin (Probable). Plays an essential role during the asexual blood stage (PubMed:28810863). At the segmented schizont stage, required for apicoplast migration and segregation into individual daughter merozoites (PubMed:28810863). Also, required for the separation of daughter merozoites in the final stages of cytokinesis (PubMed:28810863). Essential for merozoite invasion of, but not adhesion to or reorientation towards, host erythrocytes (PubMed:28810863).|||Belongs to the actin family.|||Conditional knockout at the ring stage results in the production of merozoites; however, these merozoites fail to start a new infection cycle due to a failure to invade new host erythrocytes (PubMed:28810863). During schizogony, daughter merozoite development and segmentation is abnormal and is characterized by the presence of aberrant membranous pockets adjacent to the food vacuole (PubMed:28810863). Apicoplasts have few branches and collapse close to the food vacuole failing to migrate to individual daughter cells (PubMed:28810863). No defect in secretory organelles or mitochondria and the formation of Maurer's clefts in the host cytoplasm is normal (PubMed:28810863). Egress from host erythrocytes is normal; however, some merozoites stayed conjoined, remaining connected to each other and to the central food vacuole (PubMed:28810863). No defect in microneme secretion (PubMed:28810863). Merozoite attachment to the host erythrocyte, reorientation and secretion of RON proteins are normal (PubMed:28810863). However, the formation of the circular junction between the parasite and host cell membranes is impaired and merozoites are incapable of deforming and invading host erythrocytes (PubMed:28810863). Production of gametocytes is normal (PubMed:28810863).|||Cytoplasm|||Expressed during the asexual blood stage, including in trophozoites, schizonts and merozoites (at protein level) (PubMed:28810863). Expression increases at the late trophozoite stage (at protein level) (PubMed:28810863).|||Monomer (G-actin) (PubMed:24743229). Oligomer (F-actin) (PubMed:24743229, PubMed:28923924). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix (PubMed:24743229, PubMed:28923924). Unlike for mammalian monomeric actin, parasite monomeric actin is able to induce oligomerization in the presence of ATP or ADP (PubMed:24743229). Mg(2+), which is used to coordinate ATP, is required for polymerization (PubMed:24743229). Interacts with MyoA (PubMed:33767187). Interacts with DNase I with low affinity (By similarity).|||Nucleus|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0730300 ^@ http://purl.uniprot.org/uniprot/Q8IBF6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0922500 ^@ http://purl.uniprot.org/uniprot/P27362 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/36329:PF3D7_1235200 ^@ http://purl.uniprot.org/uniprot/Q8I570 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1423600 ^@ http://purl.uniprot.org/uniprot/Q8ILL6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_0827900 ^@ http://purl.uniprot.org/uniprot/C0H4Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/36329:PF3D7_0517400 ^@ http://purl.uniprot.org/uniprot/Q8I3T4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24 family. SPT16 subfamily.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Component of the FACT complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0810300 ^@ http://purl.uniprot.org/uniprot/C0H4T6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Enzyme with a broad specificity.|||Membrane http://togogenome.org/gene/36329:PF3D7_0508000 ^@ http://purl.uniprot.org/uniprot/Q8I423 ^@ Developmental Stage|||Subcellular Location Annotation ^@ Cell membrane|||Cell surface|||Localizes to the merozoite surface. Mostly concentrated in secretory organelles at the apical end of the parasite, exclusively at an early stage of schizont development. Probably localizes in the rhoptry organelles. http://togogenome.org/gene/36329:PF3D7_1223400 ^@ http://purl.uniprot.org/uniprot/Q8I5I3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1465800 ^@ http://purl.uniprot.org/uniprot/Q8IKH9 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/36329:PF3D7_1440800 ^@ http://purl.uniprot.org/uniprot/Q8IL62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1446200 ^@ http://purl.uniprot.org/uniprot/Q8IL11 ^@ Similarity ^@ Belongs to the peptidase M17 family. http://togogenome.org/gene/36329:PF3D7_0711000 ^@ http://purl.uniprot.org/uniprot/P46468 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_0316300.1 ^@ http://purl.uniprot.org/uniprot/C0H477|||http://purl.uniprot.org/uniprot/O77392 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/36329:PF3D7_0214100 ^@ http://purl.uniprot.org/uniprot/O96221 ^@ Similarity ^@ Belongs to the WD repeat SEC31 family. http://togogenome.org/gene/36329:PF3D7_1009200 ^@ http://purl.uniprot.org/uniprot/Q8IJV3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1213500 ^@ http://purl.uniprot.org/uniprot/Q8I5S0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0822000 ^@ http://purl.uniprot.org/uniprot/Q8IB54 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/36329:PF3D7_0722600 ^@ http://purl.uniprot.org/uniprot/Q8IBM7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_0923700 ^@ http://purl.uniprot.org/uniprot/C0H554 ^@ Similarity ^@ Belongs to the CFAP298 family. http://togogenome.org/gene/36329:PF3D7_1364800 ^@ http://purl.uniprot.org/uniprot/Q8ID59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0303300 ^@ http://purl.uniprot.org/uniprot/O77315 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1302800 ^@ http://purl.uniprot.org/uniprot/Q8IET7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/36329:PF3D7_1311500 ^@ http://purl.uniprot.org/uniprot/Q8IEK3 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_0409900 ^@ http://purl.uniprot.org/uniprot/Q8I1V9 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1237000 ^@ http://purl.uniprot.org/uniprot/Q8I553 ^@ Similarity|||Subunit ^@ Belongs to the ubiquitin-activating E1 family.|||Heterodimer. http://togogenome.org/gene/36329:PF3D7_0503000 ^@ http://purl.uniprot.org/uniprot/C0H4C3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/36329:PF3D7_1365900 ^@ http://purl.uniprot.org/uniprot/Q8ID50 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Component of the 60S subunit of the ribosome.|||Cytoplasm|||In the C-terminal section; belongs to the eukaryotic ribosomal protein eL40 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0605000 ^@ http://purl.uniprot.org/uniprot/C6KSP8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/36329:PF3D7_1301700 ^@ http://purl.uniprot.org/uniprot/Q8IEJ0 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ At the asexual blood stage, causes Maurer's cleft swelling and fragmentation, aberrant knob formation, with fewer and enlarged knobs, defective PfEMP1 trafficking characterized by impaired EMP1 surface expression and EMP1 accumulation at Maurer's clefts and a loss of adhesion of host infected erythrocytes to endothelial cell ligands (PubMed:32184257). Infected erythrocytes have decreased cellular rigidity and increased osmotic fragility (PubMed:32184257). Parasite growth is faster (PubMed:32184257).|||During the asexual blood stage and probably at the ring/trophozoite stages, plays a role in Maurer's cleft formation and/or morphology (PubMed:32184257). Also, involved in the loading of the virulence factor EMP1 into the Maurer's cleft membrane (PubMed:32184257). By binding to host chemokine CX3CL1, mediates the cytoadherence of host erythrocytes infected with parasite mature forms (late trophozoite and schizont) to endothelial cells, which sequesters them away from the circulation and thus prevents their elimination by the host spleen (PubMed:27653778).|||Expressed during the asexual blood stage in late rings, trophozoites and schizonts (at protein level) (PubMed:27653778, PubMed:24983235, PubMed:32184257). Expressed in gametocytes (at protein level) (PubMed:27653778).|||Host cell membrane|||Monomer (PubMed:27653778, PubMed:31356937). May form (via the first cytoplasmic domain) homodimers or homotrimers; disulfide-linked (PubMed:27653778, PubMed:31356937). Interacts with MAHRP1 (PubMed:32184257). May interact (via first cytoplasmic domain) with SBP1; the interaction is likely to occur at the ring stage in the Maurer's clefts and is weaken by ATP (PubMed:31356937). Interacts (via extracellular domain) with human chemokine CX3CL1; the interaction mediates the adhesion of infected erythrocytes with endothelial cells (PubMed:27653778).|||Potential vaccine candidate as CBP2-based peptides or antibodies against CBP2 prevent adhesion of infected erythrocytes to endothelial cells.|||The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (By similarity).|||The first cytoplasmic domain binds ATP and nucleic acids such as RNA and DNA in vitro. http://togogenome.org/gene/36329:PF3D7_0503800 ^@ http://purl.uniprot.org/uniprot/Q8I463 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/36329:PF3D7_0215800 ^@ http://purl.uniprot.org/uniprot/O96237 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC5 family.|||Component of the origin recognition complex (ORC) (By similarity). Interacts with PCNA1; the interaction occurs during the trophozoite stage but not at the late schizont stage (PubMed:18554328).|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level).|||Nucleus http://togogenome.org/gene/36329:PF3D7_1115300 ^@ http://purl.uniprot.org/uniprot/Q8I6U5 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_0517700 ^@ http://purl.uniprot.org/uniprot/Q8I3T1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit B family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/36329:PF3D7_0315500 ^@ http://purl.uniprot.org/uniprot/O97270 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL29 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_0705900 ^@ http://purl.uniprot.org/uniprot/C0H4L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0319400 ^@ http://purl.uniprot.org/uniprot/O97277 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0905200 ^@ http://purl.uniprot.org/uniprot/Q8I397 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0605900 ^@ http://purl.uniprot.org/uniprot/C6KSQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0530200 ^@ http://purl.uniprot.org/uniprot/Q8I0U9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1325000 ^@ http://purl.uniprot.org/uniprot/Q8IE68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family. SmF/LSm6 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1421900 ^@ http://purl.uniprot.org/uniprot/Q8ILN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/36329:PF3D7_0927600 ^@ http://purl.uniprot.org/uniprot/Q8I2N3 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/36329:PF3D7_1019400 ^@ http://purl.uniprot.org/uniprot/Q8IJK8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/36329:PF3D7_0404700 ^@ http://purl.uniprot.org/uniprot/Q8I1Y2 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/36329:PF3D7_0710600 ^@ http://purl.uniprot.org/uniprot/Q8IBY4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/36329:PF3D7_1107800 ^@ http://purl.uniprot.org/uniprot/Q8IIS4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1356300 ^@ http://purl.uniprot.org/uniprot/Q8IDD9 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1212800 ^@ http://purl.uniprot.org/uniprot/Q8I5S5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster.|||Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1205100 ^@ http://purl.uniprot.org/uniprot/Q8I5Z4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SepSecS family.|||Converts O-phosphoseryl-tRNA(Sec) to selenocysteinyl-tRNA(Sec) required for selenoprotein biosynthesis.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0322900 ^@ http://purl.uniprot.org/uniprot/O97313 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS1 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (Probable). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).|||Component of the small ribosomal subunit (PubMed:24913268, PubMed:26432834). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_1443300 ^@ http://purl.uniprot.org/uniprot/Q8IL38 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus|||Plays a role in U6 snRNP assembly and function. Binds to the 3' end of U6 snRNA. http://togogenome.org/gene/36329:PF3D7_0925600 ^@ http://purl.uniprot.org/uniprot/Q8I2Q2 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/36329:PF3D7_0607300 ^@ http://purl.uniprot.org/uniprot/C6KSS1 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1203200 ^@ http://purl.uniprot.org/uniprot/Q8I613 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP14 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm|||Heterodimer with SRP9; binds RNA as heterodimer. Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9. http://togogenome.org/gene/36329:PF3D7_0511000 ^@ http://purl.uniprot.org/uniprot/Q8I3Z5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TCTP family.|||Cytoplasm|||Involved in calcium binding and microtubule stabilization. http://togogenome.org/gene/36329:PF3D7_1357300 ^@ http://purl.uniprot.org/uniprot/Q8IDD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1230700 ^@ http://purl.uniprot.org/uniprot/Q8I5B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||nuclear pore complex http://togogenome.org/gene/36329:PF3D7_0303000 ^@ http://purl.uniprot.org/uniprot/O77313 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/36329:PF3D7_1221600 ^@ http://purl.uniprot.org/uniprot/Q8I5J7 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/36329:PF3D7_0803700 ^@ http://purl.uniprot.org/uniprot/Q8IAN7 ^@ Function|||Similarity ^@ Belongs to the tubulin family.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome, suggesting that it is involved in the minus-end nucleation of microtubule assembly. http://togogenome.org/gene/36329:PF3D7_0605800 ^@ http://purl.uniprot.org/uniprot/C6KSQ6 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Essential component of the MRN complex, a complex that possesses single-stranded DNA endonuclease and 3' to 5' exonuclease activities, and plays a central role in double-strand break (DSB) repair, chromosome morphogenesis, DNA repair and meiosis. In the complex, it mediates the ATP-binding and is probably required to bind DNA ends and hold them in close proximity (By similarity).|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Probable component of the MRN complex with MRE11.|||The zinc-hook, which separates the large intramolecular coiled coil regions, contains 2 Cys residues that coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another RAD50 molecule, thereby forming a V-shaped homodimer. The two heads of the homodimer, which constitute the ATP-binding domain, interact with the MRE11 homodimer (By similarity).|||telomere http://togogenome.org/gene/36329:PF3D7_1451800 ^@ http://purl.uniprot.org/uniprot/Q8IKV8 ^@ Similarity ^@ Belongs to the VPS10-related sortilin family. http://togogenome.org/gene/36329:PF3D7_0321900 ^@ http://purl.uniprot.org/uniprot/C0H483 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAPT1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1003800 ^@ http://purl.uniprot.org/uniprot/Q8IJZ9 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/36329:PF3D7_1465100 ^@ http://purl.uniprot.org/uniprot/Q8IKI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COG6 family.|||Component of the conserved oligomeric Golgi complex.|||Golgi apparatus membrane|||Membrane|||Required for normal Golgi function. http://togogenome.org/gene/36329:PF3D7_1452300 ^@ http://purl.uniprot.org/uniprot/Q8IKV3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/36329:PF3D7_0928900 ^@ http://purl.uniprot.org/uniprot/Q8I2M1 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/36329:PF3D7_0312400 ^@ http://purl.uniprot.org/uniprot/O77344 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. GSK-3 subfamily. http://togogenome.org/gene/36329:PF3D7_0913200 ^@ http://purl.uniprot.org/uniprot/Q8I320 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/36329:PF3D7_0305500 ^@ http://purl.uniprot.org/uniprot/O97239 ^@ Biotechnology|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dopey family.|||Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||May be involved in protein traffic between late Golgi and early endosomes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1475700 ^@ http://purl.uniprot.org/uniprot/Q8IK81 ^@ Similarity ^@ Belongs to the tubulin family. http://togogenome.org/gene/36329:PF3D7_0216600 ^@ http://purl.uniprot.org/uniprot/O96245 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SWEET sugar transporter family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1106100 ^@ http://purl.uniprot.org/uniprot/Q8IIU2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/36329:PF3D7_0613800 ^@ http://purl.uniprot.org/uniprot/C6KSY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0914600 ^@ http://purl.uniprot.org/uniprot/Q8I306 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELOF1 family.|||Nucleus|||Transcription elongation factor implicated in the maintenance of proper chromatin structure in actively transcribed regions. http://togogenome.org/gene/36329:PF3D7_1333300 ^@ http://purl.uniprot.org/uniprot/Q8IDZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0323400 ^@ http://purl.uniprot.org/uniprot/O97302 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:21909261, PubMed:25583518, PubMed:27374406, PubMed:28186186, PubMed:30542156). Within the complex, interacts with CyRPA (PubMed:28186186, PubMed:30542156). CyRPA recruitment of RIPR to RH5-P113-BSG leads to the formation of the PfRH5 adhesion complex which probably in turn releases RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186).|||Conditional knockdown causes loss of cell growth and severely impairs merozoite invasion of erythrocytes. Attachment to and deformation of erythrocyte membrane is normal, however the subsequent step, which triggers an increase in Ca(2+) from the attached merozoite into the erythrocyte, is impaired.|||Contains disulfide bonds.|||Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:21909261, PubMed:25583518, PubMed:27374406, PubMed:27692771). As part of the PfRH5 adhesion complex, facilitates the interaction of RH5 and human BSG required for the Ca(2+) release into the erythrocyte (PubMed:27374406).|||Expressed in late throphozoide to schizonts and in merozoites (at protein level).|||Host cell membrane|||Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.|||Proteolytically cleaved into two chains of 125kDa and 65kDa which remain associated. The cleavage occurs at the schizont stage prior to the release of merozoites.|||Secreted|||microneme lumen http://togogenome.org/gene/36329:PF3D7_1332900 ^@ http://purl.uniprot.org/uniprot/Q8IDZ9 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1233000 ^@ http://purl.uniprot.org/uniprot/Q8I592 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1005000 ^@ http://purl.uniprot.org/uniprot/Q8I716 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1421200 ^@ http://purl.uniprot.org/uniprot/Q8ILN8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/36329:PF3D7_1325200 ^@ http://purl.uniprot.org/uniprot/Q8IE66 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/36329:PF3D7_1304100 ^@ http://purl.uniprot.org/uniprot/Q8IES4 ^@ Similarity ^@ Belongs to the ATP-dependent DNA ligase family. http://togogenome.org/gene/36329:PF3D7_0626800 ^@ http://purl.uniprot.org/uniprot/C6KTA4 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/36329:PF3D7_1465500 ^@ http://purl.uniprot.org/uniprot/Q8IKI3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0522500 ^@ http://purl.uniprot.org/uniprot/C0H4F9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL17 family. http://togogenome.org/gene/36329:PF3D7_0505200 ^@ http://purl.uniprot.org/uniprot/Q8I450 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1244700 ^@ http://purl.uniprot.org/uniprot/Q8I4Y4 ^@ Similarity ^@ Belongs to the FAM133 family. http://togogenome.org/gene/36329:PF3D7_0720800 ^@ http://purl.uniprot.org/uniprot/Q8IBP3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Cytoplasm|||Homodimer.|||Pyrophosphatase that hydrolyzes non-canonical purine nucleotides such as inosine triphosphate (ITP), deoxyinosine triphosphate (dITP) or xanthosine 5'-triphosphate (XTP) to their respective monophosphate derivatives. The enzyme does not distinguish between the deoxy- and ribose forms. Probably excludes non-canonical purines from RNA and DNA precursor pools, thus preventing their incorporation into RNA and DNA and avoiding chromosomal lesions. http://togogenome.org/gene/36329:PF3D7_1138100 ^@ http://purl.uniprot.org/uniprot/Q8IHY3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a sulfur carrier required for 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of cytosolic tRNA(Lys), tRNA(Glu) and tRNA(Gln). Serves as sulfur donor in tRNA 2-thiolation reaction by being thiocarboxylated (-COSH) at its C-terminus by the MOCS3/UBA4 homolog. The sulfur is then transferred to tRNA to form 2-thiolation of mcm(5)S(2)U. Also acts as a ubiquitin-like protein (UBL) that is covalently conjugated via an isopeptide bond to lysine residues of target proteins. The thiocarboxylated form serves as substrate for conjugation and oxidative stress specifically induces the formation of UBL-protein conjugates.|||Belongs to the URM1 family.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of the MOCS3/UBA4 homolog, then thiocarboxylated (-COSH) via the rhodanese domain of the MOCS3/UBA4 homolog.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0528200 ^@ http://purl.uniprot.org/uniprot/Q8I3I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1359300 ^@ http://purl.uniprot.org/uniprot/Q8IDB6 ^@ Similarity ^@ Belongs to the RNR ribonuclease family. http://togogenome.org/gene/36329:PF3D7_1433600 ^@ http://purl.uniprot.org/uniprot/Q8ILC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1132700 ^@ http://purl.uniprot.org/uniprot/Q8II37 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/36329:PF3D7_1420900 ^@ http://purl.uniprot.org/uniprot/Q8ILP1 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/36329:PF3D7_0614400 ^@ http://purl.uniprot.org/uniprot/C6KSY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1212700 ^@ http://purl.uniprot.org/uniprot/Q8I5S6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit A family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm|||RNA-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. http://togogenome.org/gene/36329:PF3D7_1428800.1 ^@ http://purl.uniprot.org/uniprot/Q8ILH6 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/36329:PF3D7_0710400 ^@ http://purl.uniprot.org/uniprot/A0A143ZWE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0517600 ^@ http://purl.uniprot.org/uniprot/Q8I3T2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the F-actin-capping protein beta subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0825600 ^@ http://purl.uniprot.org/uniprot/Q8IB89 ^@ Similarity ^@ Belongs to the PET191 family. http://togogenome.org/gene/36329:PF3D7_0703200 ^@ http://purl.uniprot.org/uniprot/Q8IC38 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0305200 ^@ http://purl.uniprot.org/uniprot/O97237 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1105000 ^@ http://purl.uniprot.org/uniprot/Q8IIV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_1411200 ^@ http://purl.uniprot.org/uniprot/Q8ILY3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/36329:PF3D7_1450100 ^@ http://purl.uniprot.org/uniprot/Q8IKX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits. http://togogenome.org/gene/36329:PF3D7_1337000 ^@ http://purl.uniprot.org/uniprot/A0A5K1K885 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/36329:PF3D7_1442500 ^@ http://purl.uniprot.org/uniprot/Q8IL46 ^@ Function|||Similarity ^@ Belongs to the protein prenyltransferase subunit alpha family.|||Catalyzes the transfer of a geranyl-geranyl moiety from geranyl-geranyl pyrophosphate to cysteines occuring in specific C-terminal amino acid sequences. http://togogenome.org/gene/36329:PF3D7_1403100 ^@ http://purl.uniprot.org/uniprot/C6S3H2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1114100.1 ^@ http://purl.uniprot.org/uniprot/Q8IIM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1117100 ^@ http://purl.uniprot.org/uniprot/Q8IIJ6 ^@ Developmental Stage|||Domain|||Function|||Similarity ^@ Belongs to the peptidase C12 family.|||Expressed during the parasite blood stage, in schizonts (at protein level).|||The Asn-rich domain is dispensable for deubiquitinating and deneddylating activities.|||Thiol protease that recognizes and hydrolyzes a peptide bond at the C-terminal glycine of either ubiquitin or NEDD8. http://togogenome.org/gene/36329:PF3D7_1130200 ^@ http://purl.uniprot.org/uniprot/Q8II61 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/36329:PF3D7_0218700 ^@ http://purl.uniprot.org/uniprot/O96267 ^@ Similarity ^@ Belongs to the SNW family. http://togogenome.org/gene/36329:PF3D7_1459700 ^@ http://purl.uniprot.org/uniprot/Q8IKN4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NnrE/AIBP family.|||Binds 1 potassium ion per subunit.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX. http://togogenome.org/gene/36329:PF3D7_1215200 ^@ http://purl.uniprot.org/uniprot/Q8I5Q4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_1358800 ^@ http://purl.uniprot.org/uniprot/Q8IDB0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/36329:PF3D7_1337100 ^@ http://purl.uniprot.org/uniprot/Q8IDW1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_1030600 ^@ http://purl.uniprot.org/uniprot/Q8IJ99 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Component of the EKC/KEOPS complex that is required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. The complex is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Likely plays a direct catalytic role in this reaction, but requires other protein(s) of the complex to fulfill this activity.|||Component of the EKC/KEOPS complex; the whole complex dimerizes.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0820700 ^@ http://purl.uniprot.org/uniprot/Q8I6S5 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_0721900 ^@ http://purl.uniprot.org/uniprot/C0H4P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1408100 ^@ http://purl.uniprot.org/uniprot/Q8IM15 ^@ Activity Regulation|||Caution|||Developmental Stage|||Disruption Phenotype|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A1 family.|||Dimerization causes loss of catalytic activity (PubMed:20435072). Inhibited by pepstatin A (PubMed:16624575). Inhibited by Zn(2+) (PubMed:20435072).|||During the asexual blood stage, catalyzes the cleavage of denatured host hemoglobin (Hb) or globins (PubMed:16624575). Digestion of host Hb is an essential step which provides the parasite with amino acids for protein synthesis, and regulates osmolarity (Probable).|||Expressed during the asexual blood stage; expression begins in trophozoites and continues in schizonts (at protein level).|||It is unclear if PMIII is glycosylated as other members of the same enzyme family, ie. PMI and PMII, are not.|||Membrane|||No growth defect (PubMed:15513918). However, slight decrease in proliferation and slight increase in doubling time during the asexual blood stage in an amino acid-limited medium (PubMed:15513918). Triple knockout of PMI, PMII and PMIII causes a slight decrease in proliferation during the asexual blood stage in an amino acid-limited medium (PubMed:17581121). Quadruple knockout of PMI, PMII, PMIII and PMIV causes a decrease in proliferation, an impaired proliferation in an amino acid-limited medium, a reduced formation of haemozoin and an abnormal accumulation of endosomal vesicles inside the digestive vacuole (PubMed:17581121).|||Probable homodimer; in the zymogen form (Probable). Monomer; in the active form (PubMed:20435072). Acidification disrupts homodimerization (By similarity). Component of the hemozoin formation complex (HFC) composed of falcipain 2, plasmepsins PMII, PMIII/HAP and PMIV, heme detoxifying protein HDP and falcilysin FLN (PubMed:23471987). The HFC complex is involved in hemoglobin degradation and detoxification of heme in the food vacuole during the asexual blood stage (PubMed:23471987).|||Proteolytically cleaved into the soluble active mature form by cysteine proteases in the digestive vacuole of trophozoites (By similarity). Proteolysis requires an acidic environment (By similarity). Transprocessing may serve as an alternate activation system (PubMed:18312598).|||Unlike other plasmepsins, one of the two catalytic aspartates, Asp-157, is replaced with histidine; however, the protein is catalytic active (PubMed:16624575). Unlikely to act as a serine protease (PubMed:18312598). His-157 may stabilizes the catalysis and Asp-337 may act as both an acid and a base during catalysis.|||Vacuole lumen http://togogenome.org/gene/36329:PF3D7_1306800 ^@ http://purl.uniprot.org/uniprot/Q8IEP7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0528400 ^@ http://purl.uniprot.org/uniprot/Q8I3I3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_1212000 ^@ http://purl.uniprot.org/uniprot/Q8I5T2 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/36329:PF3D7_1417500 ^@ http://purl.uniprot.org/uniprot/Q8ILS0 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/36329:PF3D7_1116500 ^@ http://purl.uniprot.org/uniprot/Q8IIK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0503600 ^@ http://purl.uniprot.org/uniprot/Q8I465 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/36329:PF3D7_1228600 ^@ http://purl.uniprot.org/uniprot/Q8I5D2 ^@ Caution|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A truncated form of MSP9 has serine protease activity in vitro; however, it is not clear if this is physiologically relevant (PubMed:10699251). Also, the putative residues forming the catalytic triad (His-55, Asp-94, and Ser-190) are not conserved in P.vivax, P.knowlesi, and P.cynomolgi orthologs casting a doubt on the physiological relevance of the protease activity (PubMed:14630931).|||Belongs to the plasmodium ABRA family.|||Cell membrane|||During the asexual blood stage, involved in the sialic acid-independent (SAID) merozoite invasion of host erythrocytes by binding to host SLC4A1/Band 3 protein on the surface of the host erythrocyte.|||Expressed during the asexual blood stage, including in merozoites (at protein level).|||Interacts with MSP1 19kDa (MSP1p19) and 42kDa (MSP1p42) proteolytic products; the interaction is direct (PubMed:14630931, PubMed:16289042). Interacts with host SLC4A1/Band 3 protein (via the 5ABC region) (PubMed:14630931). MSP1p19 or MSP1p42 and MSP9 form a co-ligand complex that interacts with host SLC4A1/Band 3 protein (PubMed:14630931, PubMed:16289042).|||Not glycosylated.|||Parasitophorous vacuole lumen|||Secreted http://togogenome.org/gene/36329:PF3D7_1466400 ^@ http://purl.uniprot.org/uniprot/Q8IKH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0610800 ^@ http://purl.uniprot.org/uniprot/C6KSV3 ^@ Similarity|||Subunit ^@ Belongs to the transketolase family.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1460800 ^@ http://purl.uniprot.org/uniprot/Q8IKM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAPC3/SRD2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0314300 ^@ http://purl.uniprot.org/uniprot/O97275 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in the degradation of misfolded endoplasmic reticulum (ER) luminal proteins.|||Membrane http://togogenome.org/gene/36329:PF3D7_1025600 ^@ http://purl.uniprot.org/uniprot/Q8IJE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/36329:PF3D7_1217300 ^@ http://purl.uniprot.org/uniprot/A0A144A297 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family. http://togogenome.org/gene/36329:PF3D7_1226800 ^@ http://purl.uniprot.org/uniprot/Q8I5F0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1117500 ^@ http://purl.uniprot.org/uniprot/Q8IIJ2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0826500 ^@ http://purl.uniprot.org/uniprot/C0H4Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0707900 ^@ http://purl.uniprot.org/uniprot/Q8IC10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1459800 ^@ http://purl.uniprot.org/uniprot/Q8IKN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1118100 ^@ http://purl.uniprot.org/uniprot/Q8III7 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/36329:PF3D7_1128100 ^@ http://purl.uniprot.org/uniprot/Q8II82 ^@ Similarity ^@ Belongs to the prefoldin subunit alpha family. http://togogenome.org/gene/36329:PF3D7_1012300 ^@ http://purl.uniprot.org/uniprot/Q8IJS2 ^@ Similarity ^@ Belongs to the UQCRB/QCR7 family. http://togogenome.org/gene/36329:PF3D7_0612700 ^@ http://purl.uniprot.org/uniprot/C6KSX0 ^@ Developmental Stage|||Disruption Phenotype|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell surface|||Does not have erythrocyte-receptor-binding ability.|||Heterodimer; heterodimerizes with PF41. May form an antiparallel heterodimer with PF41.|||No visible phenotype. Parasites grow at normal rates in vitro.|||Processed into a soluble form.|||Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI. http://togogenome.org/gene/36329:PF3D7_0527000 ^@ http://purl.uniprot.org/uniprot/Q8I3J5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1117700 ^@ http://purl.uniprot.org/uniprot/Q7KQK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1454700 ^@ http://purl.uniprot.org/uniprot/Q8IKT2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_0214400 ^@ http://purl.uniprot.org/uniprot/O96224 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/36329:PF3D7_0111500 ^@ http://purl.uniprot.org/uniprot/Q8I231 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/36329:PF3D7_1353900 ^@ http://purl.uniprot.org/uniprot/Q8IDG2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/36329:PF3D7_1428700 ^@ http://purl.uniprot.org/uniprot/Q8ILH7 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/36329:PF3D7_1239700 ^@ http://purl.uniprot.org/uniprot/Q8I526 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_0211600 ^@ http://purl.uniprot.org/uniprot/O96196 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/36329:PF3D7_1119600 ^@ http://purl.uniprot.org/uniprot/Q8IIH1 ^@ Similarity ^@ In the C-terminal section; belongs to the peptidase M41 family.|||In the N-terminal section; belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_1037700 ^@ http://purl.uniprot.org/uniprot/Q8IJ30 ^@ Function|||Similarity ^@ Belongs to the E(R) family.|||May have a role in the cell cycle. http://togogenome.org/gene/36329:PF3D7_0211400 ^@ http://purl.uniprot.org/uniprot/Q7KWI9 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. FabH family. http://togogenome.org/gene/36329:PF3D7_1416200 ^@ http://purl.uniprot.org/uniprot/Q8ILT4 ^@ Caution|||Developmental Stage|||Function|||Similarity ^@ Belongs to the peptidase C14B family.|||Expressed during all parasite blood stages (at protein level).|||In contrast to other metacaspases of the peptidase C14B family, the catalytic histidine and cysteine residues do not appear to be conserved. Contains a serine residue at the position of the canonical catalytic cysteine which may constitute the active site.|||Protease that cleaves specifically after arginine or lysine residues. http://togogenome.org/gene/36329:PF3D7_0817500 ^@ http://purl.uniprot.org/uniprot/Q7K6B1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0825200 ^@ http://purl.uniprot.org/uniprot/Q8IB86 ^@ Similarity ^@ Belongs to the IF-3 family. http://togogenome.org/gene/36329:PF3D7_1437200 ^@ http://purl.uniprot.org/uniprot/Q8IL94 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/36329:PF3D7_1216000 ^@ http://purl.uniprot.org/uniprot/Q8I5P7 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec) (By similarity).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer (By similarity).|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0511800 ^@ http://purl.uniprot.org/uniprot/Q8I3Y8 ^@ Function|||Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family.|||Key enzyme in myo-inositol biosynthesis pathway that catalyzes the conversion of glucose 6-phosphate to 1-myo-inositol 1-phosphate in a NAD-dependent manner (By similarity). Rate-limiting enzyme in the synthesis of all inositol-containing compounds (By similarity). De novo-synthesized myo-inositol is essential for incorporation into GPI (glycosylphosphatidylinositol) glycolipids during intra-erythrocytic development (PubMed:24350823). http://togogenome.org/gene/36329:PF3D7_1116700 ^@ http://purl.uniprot.org/uniprot/Q8IIJ9 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C1 family.|||Binds 1 Cl(-) ion per heavy chain.|||Expressed during the asexual blood stage including in trophozoites and schizonts (at protein level).|||Monomer.|||Parasitophorous vacuole lumen|||Thiol protease that cleaves dipeptides from the N-terminus of protein substrates (PubMed:15304495, PubMed:20833209). Active against a broad range of dipeptide substrates composed of both polar and hydrophobic amino acids (PubMed:20833209). Proline cannot occupy the P1 position and arginine or lysine cannot occupy the P2 position of the substrate (PubMed:20833209). Involved in host hemoglobin degradation by generating dipeptides from hemoglobin-derived oligopeptides (PubMed:15304495).|||Vacuole lumen http://togogenome.org/gene/36329:PF3D7_0303400 ^@ http://purl.uniprot.org/uniprot/O97224 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_1469400 ^@ http://purl.uniprot.org/uniprot/Q8IKE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0617900 ^@ http://purl.uniprot.org/uniprot/C6KT19 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H3 family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/36329:PF3D7_1230800 ^@ http://purl.uniprot.org/uniprot/Q8I5B2 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/36329:PF3D7_1354800 ^@ http://purl.uniprot.org/uniprot/Q8IDF3 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Activated by Ca(2+).|||Belongs to the peptidase C14B family.|||Cysteine protease that cleaves specifically after arginine or lysine residues (PubMed:21858231). May play a role in apoptosis (PubMed:21858231).|||Monomer. http://togogenome.org/gene/36329:PF3D7_1360200 ^@ http://purl.uniprot.org/uniprot/Q8IDA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC3 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1247400 ^@ http://purl.uniprot.org/uniprot/Q8I4V8 ^@ Activity Regulation|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FKBP-type PPIase family.|||Cytoplasm|||Expressed during all parasite blood stages (at protein level).|||Has peptidylprolyl isomerase (PPIase) and co-chaperone activities (PubMed:15664653, PubMed:15850699). Assists protein folding by catalyzing the peptidyl conversion of cis and trans rotamers of the prolyl amide bond of protein substrates (PubMed:15664653, PubMed:15850699, PubMed:23974147). Inhibits calcineurin phosphatase activity in vitro (PubMed:15850699, PubMed:17289400, PubMed:23974147). Plays an essential role in merozoite egress from host erythrocytes (PubMed:15664653, PubMed:23974147).|||Homodimer (PubMed:17289400). Interacts (via TPR repeats) with HSP90 (probably via MEEVD motif) (PubMed:15850699, PubMed:19691130).|||Inhibited by FK506 and its derivates, such as ascomycin, and rapamycin (PubMed:15664653, PubMed:15850699). FK506 and rapamycin inhibit peptidylprolyl isomerase activity but not chaperone activity (PubMed:15664653). Inhibited by N-(2-ethyl-phenyl)-2-(3H-imidazao [4, 5-b] pyridin-2-yl-sulfanyl)-acetamide (D44) (PubMed:23974147). Not inhibited by cyclosporin A (PubMed:15664653, PubMed:15850699). Inhibition of calcineurin phosphatase activity is enhanced by FK506 (PubMed:15850699).|||Nucleus|||The PPIase FKBP-type domain contributes to the chaperone activity (PubMed:15664653). Required for the inhibition of calcineurin phosphatase activity (PubMed:15850699).|||The TPR repeats are important for the chaperone activity (PubMed:15664653). In another study, these repeats appear to be dispensable for chaperone activity (PubMed:15850699). Dispensable for PPIase activity (PubMed:15850699). Dispensable for the inhibition of calcineurin phosphatase activity (PubMed:15850699). http://togogenome.org/gene/36329:PF3D7_1033100 ^@ http://purl.uniprot.org/uniprot/Q8IJ77 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family.|||Belongs to the eukaryotic AdoMetDC family. http://togogenome.org/gene/36329:PF3D7_0920200 ^@ http://purl.uniprot.org/uniprot/Q8I2V1 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0312500 ^@ http://purl.uniprot.org/uniprot/O77343 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1311400 ^@ http://purl.uniprot.org/uniprot/Q8IEK4 ^@ Similarity ^@ Belongs to the adaptor complexes medium subunit family. http://togogenome.org/gene/36329:PF3D7_1324700 ^@ http://purl.uniprot.org/uniprot/C0H5D3 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/36329:PF3D7_0814900 ^@ http://purl.uniprot.org/uniprot/Q8IAY6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the iron/manganese superoxide dismutase family.|||Binds 1 Fe cation per subunit.|||Cytoplasm|||Destroys superoxide anion radicals which are normally produced within the cells and which are toxic to biological systems.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1116200.1 ^@ http://purl.uniprot.org/uniprot/Q8IIK4 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of Pdx1.|||Cytoplasm|||Expressed throughout development. Highest expression in segmenters stage followed by schizonts stage.|||In the presence of Pdx1, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/36329:PF3D7_0806800 ^@ http://purl.uniprot.org/uniprot/Q8IAQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1469300 ^@ http://purl.uniprot.org/uniprot/Q8IKE4 ^@ Similarity ^@ Belongs to the PNO1 family. http://togogenome.org/gene/36329:PF3D7_0904700 ^@ http://purl.uniprot.org/uniprot/Q8I3A2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/36329:PF3D7_1127100 ^@ http://purl.uniprot.org/uniprot/Q8II92 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/36329:PF3D7_0219600 ^@ http://purl.uniprot.org/uniprot/O96271 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the activator 1 large subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0621900 ^@ http://purl.uniprot.org/uniprot/C6KT56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/36329:PF3D7_0507100 ^@ http://purl.uniprot.org/uniprot/Q8I431 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL4 family. http://togogenome.org/gene/36329:PF3D7_0727400 ^@ http://purl.uniprot.org/uniprot/Q8IBI3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/36329:PF3D7_1224400 ^@ http://purl.uniprot.org/uniprot/Q8I5H3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_1329200 ^@ http://purl.uniprot.org/uniprot/Q8IE51 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0822600 ^@ http://purl.uniprot.org/uniprot/Q8IB60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1209400 ^@ http://purl.uniprot.org/uniprot/Q8I5V5 ^@ Function|||Similarity ^@ Belongs to the WD repeat CIA1 family.|||Essential component of the cytosolic iron-sulfur (Fe/S) protein assembly machinery. Required for the maturation of extramitochondrial Fe/S proteins. http://togogenome.org/gene/36329:PF3D7_1429500 ^@ http://purl.uniprot.org/uniprot/Q8ILG9 ^@ Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily. http://togogenome.org/gene/36329:PF3D7_1103600 ^@ http://purl.uniprot.org/uniprot/Q8IIW6 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1406700 ^@ http://purl.uniprot.org/uniprot/Q8IM27 ^@ Similarity ^@ Belongs to the VPS29 family. http://togogenome.org/gene/36329:PF3D7_1210900 ^@ http://purl.uniprot.org/uniprot/Q8I5U1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGM family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers the first alpha-1,4-mannose to GlcN-acyl-PI during GPI precursor assembly.|||Membrane http://togogenome.org/gene/36329:PF3D7_1311200 ^@ http://purl.uniprot.org/uniprot/Q8IEK5 ^@ Similarity ^@ Belongs to the WD repeat SMU1 family. http://togogenome.org/gene/36329:PF3D7_1441800 ^@ http://purl.uniprot.org/uniprot/Q8IL52 ^@ Biotechnology|||Similarity ^@ Belongs to the SNF7 family.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1430300 ^@ http://purl.uniprot.org/uniprot/Q8ILG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||cytosol http://togogenome.org/gene/36329:PF3D7_1441700 ^@ http://purl.uniprot.org/uniprot/Q8IL53 ^@ Similarity ^@ Belongs to the peptidase M76 family. http://togogenome.org/gene/36329:PF3D7_0824400 ^@ http://purl.uniprot.org/uniprot/Q8IB78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1303200.1 ^@ http://purl.uniprot.org/uniprot/Q8IET3 ^@ Similarity ^@ Belongs to the synaptobrevin family. http://togogenome.org/gene/36329:PF3D7_0502800 ^@ http://purl.uniprot.org/uniprot/Q8I473 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/36329:PF3D7_1122900 ^@ http://purl.uniprot.org/uniprot/Q8IID4 ^@ Biotechnology|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules. Dynein has ATPase activity; the force-producing power stroke is thought to occur on release of ADP (By similarity).|||Belongs to the dynein heavy chain family.|||Consists of at least two heavy chains and a number of intermediate and light chains.|||Dynein heavy chains probably consist of an N-terminal stem (which binds cargo and interacts with other dynein components), and the head or motor domain. The motor contains six tandemly-linked AAA domains in the head, which form a ring. A stalk-like structure (formed by two of the coiled coil domains) protrudes between AAA 4 and AAA 5 and terminates in a microtubule-binding site. A seventh domain may also contribute to this ring; it is not clear whether the N-terminus or the C-terminus forms this extra domain. There are four well-conserved and two non-conserved ATPase sites, one per AAA domain. Probably only one of these (within AAA 1) actually hydrolyzes ATP, the others may serve a regulatory function.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0417500.1 ^@ http://purl.uniprot.org/uniprot/C0H4B1 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/36329:PF3D7_0109700 ^@ http://purl.uniprot.org/uniprot/Q8I247 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with 90S and pre-40S pre-ribosomal particles.|||Belongs to the RRP36 family.|||Component of the 90S pre-ribosome involved in the maturation of rRNAs. Required for early cleavages of the pre-RNAs in the 40S ribosomal subunit maturation pathway.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0311600 ^@ http://purl.uniprot.org/uniprot/O77351 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/36329:PF3D7_1245400 ^@ http://purl.uniprot.org/uniprot/Q8I4X7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/36329:PF3D7_1229400 ^@ http://purl.uniprot.org/uniprot/Q8I5C5 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/36329:PF3D7_1341600 ^@ http://purl.uniprot.org/uniprot/Q8IDS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0521700 ^@ http://purl.uniprot.org/uniprot/Q8I3P6 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX1 subfamily. http://togogenome.org/gene/36329:PF3D7_0705400 ^@ http://purl.uniprot.org/uniprot/Q8IC16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1128400 ^@ http://purl.uniprot.org/uniprot/Q8II79 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/36329:PF3D7_1467300 ^@ http://purl.uniprot.org/uniprot/Q8IKG4 ^@ Activity Regulation|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DXR family.|||Binds 1 divalent cation per subunit. Mg(2+) or Mn(2+).|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Homodimer.|||Inhibited by fosmidomycin and its derivatives.|||apicoplast http://togogenome.org/gene/36329:PF3D7_0406200 ^@ http://purl.uniprot.org/uniprot/Q6ZMA7 ^@ Developmental Stage|||Function|||Subcellular Location Annotation ^@ Expressed in gametocytes; expression starts in young gametocytes (30-40h post-invasion of host erythrocytes) (at protein level).|||Involved in male gametogenesis (PubMed:14698439). Required for exflagellation of male gametocytes (PubMed:14698439). May play a role in parasite transmission in the mosquito (By similarity). Binds to the mosquito vector midgut (By similarity).|||Parasitophorous vacuole membrane|||Vacuole http://togogenome.org/gene/36329:PF3D7_1035200 ^@ http://purl.uniprot.org/uniprot/Q03400 ^@ Function|||Polymorphism|||Subcellular Location Annotation ^@ Diversity in S-antigen is mainly due to polymorphism in the repetitive regions.|||Parasitophorous vacuole|||S antigens are soluble heat-stable proteins present in the sera of some infected individuals. http://togogenome.org/gene/36329:PF3D7_0303500 ^@ http://purl.uniprot.org/uniprot/O97225 ^@ Similarity ^@ Belongs to the TUBGCP family. http://togogenome.org/gene/36329:PF3D7_0904500 ^@ http://purl.uniprot.org/uniprot/Q8I3A4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins.|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits. http://togogenome.org/gene/36329:PF3D7_0810200 ^@ http://purl.uniprot.org/uniprot/Q8IAT7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family. http://togogenome.org/gene/36329:PF3D7_1461300 ^@ http://purl.uniprot.org/uniprot/Q8IKL9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/36329:PF3D7_1017000 ^@ http://purl.uniprot.org/uniprot/Q7KQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0623900 ^@ http://purl.uniprot.org/uniprot/C6KT75 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family. Eukaryotic subfamily.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/36329:PF3D7_0406400 ^@ http://purl.uniprot.org/uniprot/C0H490 ^@ Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family. http://togogenome.org/gene/36329:PF3D7_0916600 ^@ http://purl.uniprot.org/uniprot/Q8I2Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM4 family.|||Cytoplasm|||S-adenosyl-L-methionine-dependent protein-lysine N-methyltransferase that methylates elongation factor 1-alpha. http://togogenome.org/gene/36329:PF3D7_0723000 ^@ http://purl.uniprot.org/uniprot/Q8IBM3 ^@ Cofactor|||Function|||Similarity ^@ Adds a GMP to the 5'-end of tRNA(His) after transcription and RNase P cleavage.|||Belongs to the tRNA(His) guanylyltransferase family.|||Binds 2 magnesium ions per subunit. http://togogenome.org/gene/36329:PF3D7_1205500 ^@ http://purl.uniprot.org/uniprot/Q8I5Z0 ^@ Similarity ^@ Belongs to the CHFR family. http://togogenome.org/gene/36329:PF3D7_1403000 ^@ http://purl.uniprot.org/uniprot/Q8IM61 ^@ Similarity ^@ Belongs to the flagellar radial spoke RSP3 family. http://togogenome.org/gene/36329:PF3D7_0729500 ^@ http://purl.uniprot.org/uniprot/Q8I6Z2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/36329:PF3D7_1429000 ^@ http://purl.uniprot.org/uniprot/Q8ILH4 ^@ Similarity ^@ Belongs to the archease family. http://togogenome.org/gene/36329:PF3D7_1406900 ^@ http://purl.uniprot.org/uniprot/Q8IM25 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_0524600 ^@ http://purl.uniprot.org/uniprot/Q8I3L9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL12 family. http://togogenome.org/gene/36329:PF3D7_1445300 ^@ http://purl.uniprot.org/uniprot/Q8IL20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_0628000 ^@ http://purl.uniprot.org/uniprot/C6KTB6 ^@ Similarity ^@ Belongs to the PTPS family. http://togogenome.org/gene/36329:PF3D7_0930900 ^@ http://purl.uniprot.org/uniprot/C0H578 ^@ Similarity ^@ Belongs to the NifU family. http://togogenome.org/gene/36329:PF3D7_1453800 ^@ http://purl.uniprot.org/uniprot/Q8IKU0 ^@ Activity Regulation|||Function|||Similarity|||Subunit ^@ Bifunctional enzyme which catalyzes the first two steps of the oxidative pentose-phosphate pathway, which represents a route for the dissimilation of carbohydrates besides glycolysis. The main function of this enzyme is to provide reducing power (NADPH) and pentose phosphates for fatty acid and nucleic acid synthesis.|||G6PD activity is inhibited by glucosamine-6-phosphate, NADPH, and 4-(4-bromophenyl)-7-(3,4-dimethoxyphenyl)-4,6,7,8-tetrahydroquinoline-2,5(1 H,3H)-dione. G6PD and 6PGL activities can be reversibly inhibited by S-glutathionylation (in vitro).|||Homotetramer.|||In the C-terminal section; belongs to the glucose-6-phosphate dehydrogenase family.|||In the N-terminal section; belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily. http://togogenome.org/gene/36329:PF3D7_1433500 ^@ http://purl.uniprot.org/uniprot/Q8ILC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II topoisomerase family.|||Control of topological states of DNA by transient breakage and subsequent rejoining of DNA strands. Topoisomerase II makes double-strand breaks.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1032100 ^@ http://purl.uniprot.org/uniprot/Q8IJ85 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/36329:PF3D7_1010600 ^@ http://purl.uniprot.org/uniprot/Q8IJT9 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/36329:PF3D7_1236800 ^@ http://purl.uniprot.org/uniprot/Q8I555 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. Isoprenylcysteine carboxyl methyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1319300 ^@ http://purl.uniprot.org/uniprot/Q8IEC3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family. http://togogenome.org/gene/36329:PF3D7_0717500 ^@ http://purl.uniprot.org/uniprot/Q8IBS5 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Induction|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by calcium (PubMed:19307175, PubMed:19666141). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (PubMed:19307175). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-234, which leads to the kinase activation (PubMed:19307175). Intracellular calcium increase is triggered by xanthurenic acid (XA), a small mosquito molecule that induces the differentiation of specialized transmission stages, the gametocytes, into male and female gametes (Probable). Activated by a decrease in temperature (20 degrees Celsius) and an increase in pH (7.6) occurring when the parasite is ingested by in the mosquito (PubMed:19666141).|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.|||Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:19307175, PubMed:19666141). Plays a central role in the host erythrocytes and hepatocytes infection cycles, sexual reproduction and mosquito transmission of the parasite. During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK5. Involved in merosome egress from host hepatocytes, probably together with CDPK5. During the asexual blood stage, involved in merozoite invasion of host erythrocytes and motility by stabilizing the inner membrane complex, a structure below the plasma membrane which acts as an anchor for the glidosome, an acto-myosin motor. Required for cell cycle progression in the male gametocyte. During male gametogenesis in the mosquito gut, required to initiate the first round of DNA replication, probably by facilitating the assembly of the pre-replicative MCM complex, to assemble the first mitotic spindle and, at the end of gametogenesis, to initiate axoneme motility, cytokinesis and subsequent exflagellation. For each of these steps, may phosphorylate SOC1, SOC2 and SOC3, respectively. Together with CDPK1, regulates ookinete gliding in the mosquito host midgut (By similarity).|||Cell membrane|||Cytoplasm|||Expressed in gametocytes (at protein level).|||Induced by xanthurenic acid (XA) and human serum.|||May be autophosphorylated on Thr-234 in vitro.|||May interact with the pre-replication MCM complex prior male gametogenesis activation.|||Myristoylated; myristoylation may target it to different subcellular compartments. During male gametogenesis, myristoylation is required to initiate DNA replication but not for mitotic spindle assembly or axoneme activation.|||Not palmitoylated.|||Replication in host erythrocytes is normal.|||The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (PubMed:19307175). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (PubMed:19307175). http://togogenome.org/gene/36329:PF3D7_1236600 ^@ http://purl.uniprot.org/uniprot/Q8I557 ^@ Similarity ^@ Belongs to the TPPP family. http://togogenome.org/gene/36329:PF3D7_0728200 ^@ http://purl.uniprot.org/uniprot/Q8IBH5 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1123700 ^@ http://purl.uniprot.org/uniprot/Q8IIC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL54 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1033600 ^@ http://purl.uniprot.org/uniprot/Q7KQL1 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/36329:PF3D7_1146900 ^@ http://purl.uniprot.org/uniprot/C6S3G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1458100 ^@ http://purl.uniprot.org/uniprot/Q8IKQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PET117 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1111300 ^@ http://purl.uniprot.org/uniprot/Q8IIP9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1434100 ^@ http://purl.uniprot.org/uniprot/Q8ILC2 ^@ Similarity ^@ Belongs to the queuine tRNA-ribosyltransferase family. http://togogenome.org/gene/36329:PF3D7_0318300 ^@ http://purl.uniprot.org/uniprot/O77374 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1317000 ^@ http://purl.uniprot.org/uniprot/Q8I6Z8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1429900 ^@ http://purl.uniprot.org/uniprot/Q8ILG5 ^@ Similarity ^@ Belongs to the helicase family. RecQ subfamily. http://togogenome.org/gene/36329:PF3D7_0422100 ^@ http://purl.uniprot.org/uniprot/Q8IFP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0803000 ^@ http://purl.uniprot.org/uniprot/Q8IAN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYF2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1213900 ^@ http://purl.uniprot.org/uniprot/A0A144A0U7 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/36329:PF3D7_1214400 ^@ http://purl.uniprot.org/uniprot/Q8I5R2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMC6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0407900 ^@ http://purl.uniprot.org/uniprot/Q9U0K7 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_1108200 ^@ http://purl.uniprot.org/uniprot/Q8IIS0 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids (PubMed:24302572, PubMed:27224426).|||Belongs to the DTD family.|||Cytoplasm|||D-aminoacyl-tRNA deacylase, with no observable activity on tRNAs charged with their cognate L-amino acid (PubMed:20007323, PubMed:24302572, PubMed:27224426). Probably acts by rejecting L-amino acids from its binding site rather than specific recognition of D-amino acids (PubMed:27224426). Catalyzes the hydrolysis of D-tyrosyl-tRNA(Tyr), has no activity on correctly charged L-tyrosyl-tRNA(Tyr) (PubMed:20007323, PubMed:24302572, PubMed:27224426). Hydrolyzes correctly charged, achiral, glycyl-tRNA(Gly) (PubMed:27224426). Deacylates mischarged D.melanogaster and E.coli glycyl-tRNA(Ala) (PubMed:28362257). Probably acts via tRNA-based rather than protein-based catalysis (PubMed:24302572, PubMed:27224426). Acts on tRNAs only when the D-amino acid is either attached to the ribose 3'-OH or transferred to the 3'-OH from the 2'-OH through rapid transesterification (PubMed:24302572). Binds a number of other D-amino acids (D-Arg, D-Glu, D-His, D-Lys, D-Ser), suggesting it may also deacylate other mischarged tRNAs (PubMed:20007323).|||Homodimer (PubMed:20007323, PubMed:24302572).|||In the crystal structures with bound ADP (PDB 3KO4, 3KO5), the adenosine moiety is thought to represent the authentic C-terminal adenosine of charged tRNA and is annotated as such in this entry (PubMed:20007323).|||Initially the conserved reside Thr-90 was thought to be a nucleophile; mutagenesis in this organism and E.coli indicates it is not. http://togogenome.org/gene/36329:PF3D7_1107200 ^@ http://purl.uniprot.org/uniprot/Q8IIT1 ^@ Similarity ^@ Belongs to the CCZ1 family. http://togogenome.org/gene/36329:PF3D7_0317700 ^@ http://purl.uniprot.org/uniprot/O77380 ^@ Similarity ^@ Belongs to the DDB1 family. http://togogenome.org/gene/36329:PF3D7_0703600 ^@ http://purl.uniprot.org/uniprot/C0H4K2 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0725200 ^@ http://purl.uniprot.org/uniprot/Q8IBJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0418200 ^@ http://purl.uniprot.org/uniprot/Q8I1Q5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Belongs to the eIF-3 subunit M family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1463200 ^@ http://purl.uniprot.org/uniprot/Q8IKK4 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/36329:PF3D7_0614300 ^@ http://purl.uniprot.org/uniprot/C6KSY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0210000 ^@ http://purl.uniprot.org/uniprot/O96183 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecE/SEC61-gamma family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1365100 ^@ http://purl.uniprot.org/uniprot/Q8ID56 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/36329:PF3D7_0903100 ^@ http://purl.uniprot.org/uniprot/Q8I3B7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/36329:PF3D7_1454500 ^@ http://purl.uniprot.org/uniprot/Q8IKT4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NifU family.|||Mitochondrion matrix|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/36329:PF3D7_0807700 ^@ http://purl.uniprot.org/uniprot/Q8IAR5 ^@ Developmental Stage|||Domain|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S1C family.|||By heat and oxidative stresses in trophozoites and schizonts (at protein level).|||Cytoplasm|||During the asexual blood stage, expressed in trophozoites, schizonts and free merozoites (at protein level).|||Host cell membrane|||Host cytoplasm|||Oligomer; may form trimers or hexamers (PubMed:24494818). Forms a complex at least composed of DegP, ENO and HSP70 (PubMed:24494818).|||Parasitophorous vacuole|||Serine protease which also acts as a protein chaperone (PubMed:24494818). Plays a role in the parasite development in host erythrocytes possibly by protecting it against thermal and oxidative stresses (PubMed:24494818).|||The PDZ domain is dispensable for protease and chaperone activities. http://togogenome.org/gene/36329:PF3D7_1348200 ^@ http://purl.uniprot.org/uniprot/Q8IDL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0414000 ^@ http://purl.uniprot.org/uniprot/Q8I1U7 ^@ Biotechnology|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylation at Lys-101 by ESCO1 is important for genome stability and S phase sister chromatid cohesion.|||Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement (By similarity).|||Component of the cohesin complex.|||Nucleus|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||The flexible SMC hinge domain, which separates the large intramolecular coiled coil regions, allows the heterotypic interaction with the corresponding domain of SMC1A or SMC1B, forming a V-shaped heterodimer. The two heads of the heterodimer are then connected by different ends of the cleavable RAD21 protein, forming a ring structure (By similarity). http://togogenome.org/gene/36329:PF3D7_1104700.1 ^@ http://purl.uniprot.org/uniprot/Q8IIV5 ^@ Similarity ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_1246800 ^@ http://purl.uniprot.org/uniprot/Q8I4W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0302000 ^@ http://purl.uniprot.org/uniprot/O97334 ^@ Similarity ^@ Belongs to the WD repeat PRL1/PRL2 family. http://togogenome.org/gene/36329:PF3D7_1115600 ^@ http://purl.uniprot.org/uniprot/Q8IIK8 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_0810100 ^@ http://purl.uniprot.org/uniprot/C0H4T5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/36329:PF3D7_0612300 ^@ http://purl.uniprot.org/uniprot/C6KSW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM234 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1430900 ^@ http://purl.uniprot.org/uniprot/Q8I6V2 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 2 family. http://togogenome.org/gene/36329:PF3D7_1366900 ^@ http://purl.uniprot.org/uniprot/Q8ID39 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0611700 ^@ http://purl.uniprot.org/uniprot/C0H4H3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/36329:PF3D7_0909800 ^@ http://purl.uniprot.org/uniprot/C0H529 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/36329:PF3D7_1244200 ^@ http://purl.uniprot.org/uniprot/Q8I4Y8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB2 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1472000 ^@ http://purl.uniprot.org/uniprot/Q8IKB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1037600 ^@ http://purl.uniprot.org/uniprot/Q8IJ31 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/36329:PF3D7_1454600 ^@ http://purl.uniprot.org/uniprot/Q8IKT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS11 family.|||chloroplast http://togogenome.org/gene/36329:PF3D7_1350100 ^@ http://purl.uniprot.org/uniprot/Q8IDJ8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0905300 ^@ http://purl.uniprot.org/uniprot/Q8I396 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/36329:PF3D7_0811000 ^@ http://purl.uniprot.org/uniprot/Q8IAU5 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/36329:PF3D7_1412100 ^@ http://purl.uniprot.org/uniprot/Q8ILX3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1460300 ^@ http://purl.uniprot.org/uniprot/C6S3J6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL29 family. http://togogenome.org/gene/36329:PF3D7_0934800 ^@ http://purl.uniprot.org/uniprot/Q7K6A0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_1338400 ^@ http://purl.uniprot.org/uniprot/Q8IDU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1008800 ^@ http://purl.uniprot.org/uniprot/Q8IJV7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1414300 ^@ http://purl.uniprot.org/uniprot/Q8ILV2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/36329:PF3D7_0816500 ^@ http://purl.uniprot.org/uniprot/Q8IB02 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/36329:PF3D7_1316100 ^@ http://purl.uniprot.org/uniprot/Q8IEF3 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/36329:PF3D7_0502000 ^@ http://purl.uniprot.org/uniprot/Q8I480 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1470000 ^@ http://purl.uniprot.org/uniprot/C6S3K2 ^@ Similarity|||Subunit ^@ Belongs to the ATG12 family.|||Forms a conjugate with ATG5. http://togogenome.org/gene/36329:PF3D7_1246100 ^@ http://purl.uniprot.org/uniprot/Q8I4X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1418000 ^@ http://purl.uniprot.org/uniprot/Q8ILR6 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/36329:PF3D7_1019900 ^@ http://purl.uniprot.org/uniprot/Q8IJK2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/36329:PF3D7_0319600 ^@ http://purl.uniprot.org/uniprot/O97319 ^@ Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family. http://togogenome.org/gene/36329:PF3D7_1145400 ^@ http://purl.uniprot.org/uniprot/Q8IHR4 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/36329:PF3D7_0813900 ^@ http://purl.uniprot.org/uniprot/Q8IAX5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/36329:PF3D7_0507200 ^@ http://purl.uniprot.org/uniprot/Q8I430 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Expressed during the parasite blood stage, specifically in schizonts (at protein level).|||Secreted|||Serine protease which may cleave PFN/profilin. http://togogenome.org/gene/36329:PF3D7_1241600 ^@ http://purl.uniprot.org/uniprot/Q8I513 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1239100 ^@ http://purl.uniprot.org/uniprot/Q8I532 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/36329:PF3D7_1010100 ^@ http://purl.uniprot.org/uniprot/Q8IJU4 ^@ Similarity ^@ Belongs to the proteasome inhibitor PI31 family. http://togogenome.org/gene/36329:PF3D7_1232100 ^@ http://purl.uniprot.org/uniprot/Q8I0V3 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/36329:PF3D7_1361200 ^@ http://purl.uniprot.org/uniprot/Q8ID94 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1218400 ^@ http://purl.uniprot.org/uniprot/Q8I5M4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0912900 ^@ http://purl.uniprot.org/uniprot/Q8I323 ^@ Similarity ^@ Belongs to the peptidase M67A family. http://togogenome.org/gene/36329:PF3D7_1247200 ^@ http://purl.uniprot.org/uniprot/Q8I4W0 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/36329:PF3D7_1367000 ^@ http://purl.uniprot.org/uniprot/Q8ID38 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/36329:PF3D7_1356900 ^@ http://purl.uniprot.org/uniprot/P61075 ^@ Activity Regulation|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Autophosphorylates in presence of cyclin cyc-1 but not in presence of cyclin cyc-3.|||Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily.|||Cytoplasm|||Expressed during the asexual blood stage; expression is low at the ring stage and peaks in trophozoites and schizonts (at protein level).|||May form a complex composed of at least the catalytic subunit CRK2 and a cyclin.|||Phosphorylation at Thr-14 or Tyr-15 inactivates the enzyme, while phosphorylation at Thr-158 activates it (By similarity). Activated by cyclin cyc-1 in vitro (PubMed:10722743, PubMed:12869562). Activated by cyclin cyc-3 in vitro (PubMed:12869562).|||Serine/threonine-protein kinase (PubMed:10722743, PubMed:12869562, PubMed:26094711). Involved in the control of the cell cycle (By similarity). Required for entry into S-phase and mitosis (By similarity). Probable component of the kinase complex that phosphorylates the repetitive C-terminus of RNA polymerase II (PubMed:12869562). In schizonts, phosphorylates ORC1 resulting in its dissociation from DNA, relocalization to the cytoplasm and likely its degradation (PubMed:26094711). http://togogenome.org/gene/36329:PF3D7_0623200 ^@ http://purl.uniprot.org/uniprot/C6KT68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 1 family.|||May play a role in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis.|||Monomer (PubMed:17258767). Homodimer; disulfide linked (PubMed:17258767, PubMed:19736991). NADP binding accelerates formation of an inactive, disulfide-linked homodimer when the protein is exposed to air for 24 h or more (in vitro); the physiological relevance of this is uncertain (PubMed:17258767).|||apicoplast http://togogenome.org/gene/36329:PF3D7_0918200.1 ^@ http://purl.uniprot.org/uniprot/C0H543 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit. http://togogenome.org/gene/36329:PF3D7_1454400 ^@ http://purl.uniprot.org/uniprot/A0A144A2H0 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/36329:PF3D7_1022200 ^@ http://purl.uniprot.org/uniprot/Q8IJI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Folate-biopterin transporter (TC 2.A.71) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1449500 ^@ http://purl.uniprot.org/uniprot/Q8IKY0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0311300 ^@ http://purl.uniprot.org/uniprot/O77353 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type II PI4K subfamily. http://togogenome.org/gene/36329:PF3D7_0422300 ^@ http://purl.uniprot.org/uniprot/Q8IFP3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin. http://togogenome.org/gene/36329:PF3D7_0515000 ^@ http://purl.uniprot.org/uniprot/Q8I3V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM CWC2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1410200 ^@ http://purl.uniprot.org/uniprot/Q8ILZ3 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/36329:PF3D7_1215900 ^@ http://purl.uniprot.org/uniprot/Q8I5P8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1134500 ^@ http://purl.uniprot.org/uniprot/Q8II19 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI inositol-deacylase family.|||Endoplasmic reticulum membrane|||Involved in inositol deacylation of GPI-anchored proteins which plays important roles in the quality control and ER-associated degradation of GPI-anchored proteins.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_1143400 ^@ http://purl.uniprot.org/uniprot/Q8IHT2 ^@ Function|||Similarity ^@ Belongs to the eIF-1A family.|||Seems to be required for maximal rate of protein biosynthesis. Enhances ribosome dissociation into subunits and stabilizes the binding of the initiator Met-tRNA(I) to 40 S ribosomal subunits. http://togogenome.org/gene/36329:PF3D7_1428200 ^@ http://purl.uniprot.org/uniprot/Q8ILI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1305600 ^@ http://purl.uniprot.org/uniprot/Q8IEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Cell membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0812600 ^@ http://purl.uniprot.org/uniprot/Q8IAW2 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1448500 ^@ http://purl.uniprot.org/uniprot/Q8IKY8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0419200 ^@ http://purl.uniprot.org/uniprot/Q8I1P5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1429800 ^@ http://purl.uniprot.org/uniprot/Q8ILG6 ^@ Subcellular Location Annotation ^@ COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1120900 ^@ http://purl.uniprot.org/uniprot/Q8IIF8 ^@ Similarity ^@ Belongs to the HSBP1 family. http://togogenome.org/gene/36329:PF3D7_0208500 ^@ http://purl.uniprot.org/uniprot/Q7KWJ1 ^@ Function|||Similarity ^@ Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis. http://togogenome.org/gene/36329:PF3D7_0705300 ^@ http://purl.uniprot.org/uniprot/Q8IC17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1218600 ^@ http://purl.uniprot.org/uniprot/Q8I5M2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0304200 ^@ http://purl.uniprot.org/uniprot/Q9NLB8 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/36329:PF3D7_1230600 ^@ http://purl.uniprot.org/uniprot/Q8I5B4 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_1251500 ^@ http://purl.uniprot.org/uniprot/A0A144A382 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_1034400 ^@ http://purl.uniprot.org/uniprot/Q8IJ66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1468700 ^@ http://purl.uniprot.org/uniprot/Q8IKF0 ^@ Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/36329:PF3D7_1017400 ^@ http://purl.uniprot.org/uniprot/Q8IJM5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/36329:PF3D7_0932100 ^@ http://purl.uniprot.org/uniprot/C0H584 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1107500 ^@ http://purl.uniprot.org/uniprot/Q8IIS7 ^@ Similarity ^@ Belongs to the UXT family. http://togogenome.org/gene/36329:PF3D7_1405800 ^@ http://purl.uniprot.org/uniprot/Q8IM36 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat BOP1/ERB1 family.|||Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.|||nucleolus|||nucleoplasm http://togogenome.org/gene/36329:PF3D7_0709000 ^@ http://purl.uniprot.org/uniprot/Q8IBZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CRT-like transporter family.|||May regulate endogenous transporter.|||Vacuole membrane http://togogenome.org/gene/36329:PF3D7_1438700 ^@ http://purl.uniprot.org/uniprot/Q7KQM1 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex - primosome/replisome) which play an essential role in the initiation of DNA synthesis (By similarity). The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands (By similarity).|||Heterodimer of a catalytic subunit and a regulatory subunit, also known as the DNA primase complex.|||The bound zinc ion is not a cofactor. It is bound to a zinc knuckle motif that may be involved in sequence recognition and the binding of ssDNA (By similarity).|||The presence of the regulatory subunit accelerates the kinetics of initiation and primer extension. http://togogenome.org/gene/36329:PF3D7_0206700 ^@ http://purl.uniprot.org/uniprot/Q7KWJ4 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/36329:PF3D7_0907800 ^@ http://purl.uniprot.org/uniprot/Q8I373 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/36329:PF3D7_0719600 ^@ http://purl.uniprot.org/uniprot/Q8IBQ6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/36329:PF3D7_1143300 ^@ http://purl.uniprot.org/uniprot/Q8IHT3 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_0719700 ^@ http://purl.uniprot.org/uniprot/Q8IBQ5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS10 family. http://togogenome.org/gene/36329:PF3D7_1430600 ^@ http://purl.uniprot.org/uniprot/Q8ILF8 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/36329:PF3D7_1207600 ^@ http://purl.uniprot.org/uniprot/Q8I0X4 ^@ Similarity ^@ Belongs to the IPP transferase family. http://togogenome.org/gene/36329:PF3D7_1440500 ^@ http://purl.uniprot.org/uniprot/Q8IL65 ^@ Similarity ^@ Belongs to the allantoicase family. http://togogenome.org/gene/36329:PF3D7_1439400 ^@ http://purl.uniprot.org/uniprot/Q8IL75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0311200 ^@ http://purl.uniprot.org/uniprot/O77354 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0816800 ^@ http://purl.uniprot.org/uniprot/Q8IB05 ^@ Similarity ^@ Belongs to the RecA family. DMC1 subfamily. http://togogenome.org/gene/36329:PF3D7_0516200 ^@ http://purl.uniprot.org/uniprot/A0A5K1K925 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS11 family.|||chloroplast http://togogenome.org/gene/36329:PF3D7_1111000 ^@ http://purl.uniprot.org/uniprot/Q8IIQ2 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0510500 ^@ http://purl.uniprot.org/uniprot/Q8I3Z9 ^@ Similarity ^@ Belongs to the type IB topoisomerase family. http://togogenome.org/gene/36329:PF3D7_0611900 ^@ http://purl.uniprot.org/uniprot/C6KSW3 ^@ Similarity ^@ Belongs to the LSM12 family. http://togogenome.org/gene/36329:PF3D7_0931700 ^@ http://purl.uniprot.org/uniprot/C0H581 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/36329:PF3D7_0922600 ^@ http://purl.uniprot.org/uniprot/C0H551 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/36329:PF3D7_0910700 ^@ http://purl.uniprot.org/uniprot/Q8I345 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/36329:PF3D7_1416900 ^@ http://purl.uniprot.org/uniprot/Q8ILS7 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/36329:PF3D7_1316800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K9E7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1107000 ^@ http://purl.uniprot.org/uniprot/Q8IIT3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1364900 ^@ http://purl.uniprot.org/uniprot/Q8ID58 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Catalyzes the ferrous insertion into protoporphyrin IX.|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1125500 ^@ http://purl.uniprot.org/uniprot/Q8IIA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Essential for pre-mRNA splicing. Implicated in the formation of stable, biologically active snRNP structures.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1219100 ^@ http://purl.uniprot.org/uniprot/Q8I5L6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin heavy chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||Membrane|||coated pit http://togogenome.org/gene/36329:PF3D7_1417300 ^@ http://purl.uniprot.org/uniprot/Q8ILS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1117800 ^@ http://purl.uniprot.org/uniprot/Q8IIJ0 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/36329:PF3D7_1144700 ^@ http://purl.uniprot.org/uniprot/Q8IHS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tic20 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1132200 ^@ http://purl.uniprot.org/uniprot/Q8II43 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/36329:PF3D7_1132800 ^@ http://purl.uniprot.org/uniprot/Q8II36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1414400 ^@ http://purl.uniprot.org/uniprot/Q8ILV1 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_0109200 ^@ http://purl.uniprot.org/uniprot/Q8I0V9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1219700 ^@ http://purl.uniprot.org/uniprot/Q7KQK1 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/36329:PF3D7_0808200 ^@ http://purl.uniprot.org/uniprot/Q8IAS0 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Autocleaved into a p16 prodomain form and two mature forms p44 and p51.|||Belongs to the peptidase A1 family.|||During the asexual blood stage, processes key proteins essential for merozoite egress and invasion of host erythrocytes (PubMed:29074775, PubMed:32109369). Cleaves and activates proteases SUB1 and SUB2 (PubMed:29074775, PubMed:32109369). May process members of the EBL and Rh protein families (PubMed:32109369). Also cleaves apical membrane protein AMA1 (PubMed:29074775). During the mosquito vector stage and probably in ookinetes, cleaves CelTOS (PubMed:29074775).|||Inhibited by small molecule 49c (PubMed:29074775). Inhibited by small molecules WM382, WM4, and WM5 (PubMed:32109369).|||secretory vesicle http://togogenome.org/gene/36329:PF3D7_1423000 ^@ http://purl.uniprot.org/uniprot/Q8ILM2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0512300 ^@ http://purl.uniprot.org/uniprot/Q8I3Y3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1415200 ^@ http://purl.uniprot.org/uniprot/Q8ILU4 ^@ Similarity ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_1472700 ^@ http://purl.uniprot.org/uniprot/Q8IKB1 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/36329:PF3D7_0806200 ^@ http://purl.uniprot.org/uniprot/C0H4S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1034200 ^@ http://purl.uniprot.org/uniprot/Q8IJ68 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/36329:PF3D7_0916500 ^@ http://purl.uniprot.org/uniprot/C0H540 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/36329:PF3D7_0424100 ^@ http://purl.uniprot.org/uniprot/Q8IFM5 ^@ Biotechnology|||Developmental Stage|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cleaved into a 45kDa form during merozoite invasion of host erythrocyte.|||Essential for the invasion of host erythrocytes by blood stage merozoites (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:18827878, PubMed:19000690, PubMed:31204103, PubMed:28186186, PubMed:28409866). By binding P113 at the surface of the merozoite and human BSG/basigin on the erythrocyte membrane, leads to the establishment of a tight junction between the merozoite and host erythrocyte membranes (PubMed:25583518, PubMed:27374406, PubMed:25296023, PubMed:22080952, PubMed:28186186). In addition, the interaction with BSG results in BSG dimerization which triggers an increase in intracellular Ca(2+) in the erythrocyte (PubMed:27374406, PubMed:28409866). This essential step leads to a rearrangement of the erythrocyte cytoskeleton required for the merozoite invasion (PubMed:28409866).|||Expressed during parasite asexual blood stages, specifically at the schizont stage and in free merozoites (at protein level).|||Forms a complex composed of RH5, P113 and human BSG/basigin; the complex bridges the merozoite and host erythrocyte membranes (PubMed:28186186). Within the complex, interacts (via C-terminus) with human BSG/basigin isoform 2 (via the extracellular domain); the interaction is independent of BSG glycosylation status (PubMed:22080952, PubMed:25296023, PubMed:28186186, PubMed:24297912, PubMed:30542156, PubMed:28096331). Weakly interacts with P.troglodytes BSG but not with G.gorilla BSG (PubMed:24297912). Also, interacts (via N-terminus) with P113; the interaction tethers RH5 to the merozoite membrane (PubMed:28186186). Component of the PfRH5 adhesion complex composed of 1 copy of CyRPA, RH5 and RIPR; the complex is formed during merozoite invasion of host erythrocytes specifically at the interface between the parasite and host membranes (PubMed:25583518, PubMed:27374406, PubMed:28186186, PubMed:21909261, PubMed:30542156). Within the complex, interacts with CyRPA (PubMed:28186186, PubMed:30542156). CyRPA recruits RIPR to the RH5-P113-BSG complex; the formation of the PfRH5 adhesion complex increases the affinity of RH5 for BSG and probably leads to the release of RH5 from P113 while maintaining the interaction of the PfRH5 adhesion complex with BSG (PubMed:28186186, PubMed:30542156).|||Host cell membrane|||Potential candidate for the development of parasite blood stage vaccines. In vitro and in vivo, induces neutralizing antibodies capable of inhibiting merozoite invasion of host erythrocytes.|||Secreted|||rhoptry lumen http://togogenome.org/gene/36329:PF3D7_0929000 ^@ http://purl.uniprot.org/uniprot/Q8I2M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF7 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1222300 ^@ http://purl.uniprot.org/uniprot/Q8I0V4 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/36329:PF3D7_1220500 ^@ http://purl.uniprot.org/uniprot/Q8I5K8 ^@ Function|||Similarity ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine in 18S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family. http://togogenome.org/gene/36329:PF3D7_0724900 ^@ http://purl.uniprot.org/uniprot/Q8IBK2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_1402500 ^@ http://purl.uniprot.org/uniprot/Q8IM64 ^@ Similarity ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family. http://togogenome.org/gene/36329:PF3D7_0308900 ^@ http://purl.uniprot.org/uniprot/O77327 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0218400 ^@ http://purl.uniprot.org/uniprot/O96264 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_1235600 ^@ http://purl.uniprot.org/uniprot/Q8I566 ^@ Activity Regulation|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the interconversion of serine to glycine accompanied with the production of 5,10-methylenetetrahydrofolate, a source of one-carbon units used by thymidylate synthase to convert dUMP to dTMP for DNA synthesis (PubMed:11071283, PubMed:19591883, PubMed:24914963). Binds to its own mRNA and to the mRNA of bifunctional dihydrofolate reductase-thymidylate synthase (DHFR-TS) in vitro; the physiological relevance of this interaction is not clear (PubMed:19591883).|||Cytoplasm|||Expressed during the parasite erythrocyte stages, namely in trophozoites and schizonts.|||Homodimer.|||Mitochondrion matrix|||Nucleus|||Redox regulation; active in reducing conditions, inactive in oxidizing conditions. The reduction of the cysteine pairs allows the access binding of the tetrahydrofolate substrate to its binding site. This mechanism appears to be unique to Plasmodium species.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1310900 ^@ http://purl.uniprot.org/uniprot/Q8I6T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS15 family. http://togogenome.org/gene/36329:PF3D7_0603100 ^@ http://purl.uniprot.org/uniprot/C6KSN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF-assemblin family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1433000 ^@ http://purl.uniprot.org/uniprot/C6S3I4 ^@ Similarity ^@ Belongs to the NOP10 family. http://togogenome.org/gene/36329:PF3D7_1337800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8H0 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Activated by calcium (PubMed:20466936). Upon calcium binding to the EF-hand domains, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (By similarity). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-285, which leads to the kinase activation (By similarity).|||Autophosphorylated in vitro.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.|||Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (PubMed:20466936, PubMed:31915223). Plays a central role in host erythrocytes and hepatocytes infection cycles (PubMed:20466936, PubMed:29487234). During the liver stage, involved in sporozoite motility and thus in sporozoite invasion of host hepatocytes, probably together with CDPK1 and CDPK4 (By similarity). Involved in merosome egress from host hepatocytes, probably together with CDPK4 (By similarity). Required for the release of hepatic merozoites from merosomes in the host blood stream (By similarity). During the asexual blood stage, required for merozoite egress from host erythrocytes by triggering microneme secretion (PubMed:20466936, PubMed:29487234). Phosphorylates transporter NPT1 at late schizont stage (PubMed:31915223).|||Cell membrane|||Cytoplasm|||Expressed at the blood stage in schizonts (at protein level).|||Impaired replication in host erythrocytes (PubMed:20466936). Parasite development is arrested at the late schizont stage before the rupture of the parasitophorous vacuole membrane rupture, however, the daughter merozoites are fully mature and their number per schizont is not affected (PubMed:20466936, PubMed:29487234). Loss of secretion of AMA1-containing and EBA175-containing micronemes (PubMed:29487234). SUB1-mediated processing of AMA1 and SERA5, which is part of the protease cascade involved in parasite egress, is reduced (PubMed:29487234). At the late schizont stage, phosphorylation of several transmembrane- and membrane-associated proteins and proteins associated with transport activity is reduced (PubMed:31915223).|||May be palmitoylated.|||The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive (By similarity). The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains (By similarity).|||microneme membrane http://togogenome.org/gene/36329:PF3D7_1450000 ^@ http://purl.uniprot.org/uniprot/Q8IKX5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_1138400 ^@ http://purl.uniprot.org/uniprot/Q8IHY1 ^@ Caution|||Cofactor|||Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Binds 2 magnesium ions per subunit (By similarity). Is also active with manganese (in vitro) (By similarity).|||Catalyzes the synthesis of the second messenger cGMP from GTP (Probable). In asexual blood stage schizonts, required for cGMP production which is essential for PKG activation, PKG-dependent Ca(2+) release, and ultimately merozoite egress from host erythrocytes (PubMed:33500341).|||Cell membrane|||Cytoplasmic vesicle membrane|||During the parasite blood stage, highly expressed in mature schizonts and in gametocytes.|||In the C-terminal section; belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||In the N-terminal section; belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Knockout at the asexual blood stage causes growth arrest (PubMed:33500341). Mature schizonts accumulate in host erythrocytes due to a defect in merozoite egress (PubMed:33500341). Lack of swelling or rupture of the parasitophorous vacuole membrane and, no Ca(2+) release from intracellular stores and no secretion of protease SERA5 (PubMed:33500341). Mature schizonts fail to synthesize cGMP; no defect in cAMP levels (PubMed:33500341).|||The N-terminus contains a P-type ATPase-like domain which may be important for guanylate cyclase activity.|||Unlike the two guanylate cyclase domains of GCbeta, the guanylate cyclase domains 1 and 2 of GCalpha lack catalytic activity when expressed on their own or in combination. http://togogenome.org/gene/36329:PF3D7_0307400 ^@ http://purl.uniprot.org/uniprot/O97252 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/36329:PF3D7_1224900 ^@ http://purl.uniprot.org/uniprot/Q8I5G8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1314200 ^@ http://purl.uniprot.org/uniprot/Q8IEH2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the reverse transcriptase family. Telomerase subfamily.|||Nucleus|||Telomerase is a ribonucleoprotein enzyme essential for the replication of chromosome termini in most eukaryotes. It elongates telomeres. It is a reverse transcriptase that adds simple sequence repeats to chromosome ends by copying a template sequence within the RNA component of the enzyme.|||telomere http://togogenome.org/gene/36329:PF3D7_1474100 ^@ http://purl.uniprot.org/uniprot/Q8IK97 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family. http://togogenome.org/gene/36329:PF3D7_1108400 ^@ http://purl.uniprot.org/uniprot/Q8IIR9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_0511200 ^@ http://purl.uniprot.org/uniprot/Q8I0W9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/36329:PF3D7_0110400 ^@ http://purl.uniprot.org/uniprot/Q8I241 ^@ Similarity ^@ Belongs to the archaeal RpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/36329:PF3D7_0915000 ^@ http://purl.uniprot.org/uniprot/Q8I302 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1015300 ^@ http://purl.uniprot.org/uniprot/Q8IJP2 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Cotranslationally removes the N-terminal methionine from nascent proteins (PubMed:16983082, PubMed:27023914). The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (By similarity). May play an important role in parasite growth during the blood asexual stage (PubMed:16983082).|||Highest activity with zinc and cobalt ions, and low activity with manganese or divalent iron ions (PubMed:27023914). Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with zinc, cobalt, manganese or divalent iron ions. Has high activity with zinc; zinc cofactor is transferred into the active site region by the ZNG1 zinc chaperone (By similarity).|||Inhibited by pyrimidine derivative XC11. http://togogenome.org/gene/36329:PF3D7_0505500 ^@ http://purl.uniprot.org/uniprot/Q8I447 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/36329:PF3D7_1351400 ^@ http://purl.uniprot.org/uniprot/Q8IDI5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/36329:PF3D7_0219400.1 ^@ http://purl.uniprot.org/uniprot/Q8I655 ^@ Similarity ^@ Belongs to the RAMP4 family. http://togogenome.org/gene/36329:PF3D7_0933900 ^@ http://purl.uniprot.org/uniprot/Q8I2H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0518000 ^@ http://purl.uniprot.org/uniprot/C0H4E6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOSIP family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0211300 ^@ http://purl.uniprot.org/uniprot/Q8I661 ^@ Similarity ^@ Belongs to the CBP3 family. http://togogenome.org/gene/36329:PF3D7_1442200 ^@ http://purl.uniprot.org/uniprot/Q8IL49 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. http://togogenome.org/gene/36329:PF3D7_1126000 ^@ http://purl.uniprot.org/uniprot/Q8IIA4 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_1215000 ^@ http://purl.uniprot.org/uniprot/Q8I5Q6 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/36329:PF3D7_0915100 ^@ http://purl.uniprot.org/uniprot/Q8I301 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_0317600 ^@ http://purl.uniprot.org/uniprot/O77381 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/36329:PF3D7_0914300 ^@ http://purl.uniprot.org/uniprot/C0H537 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM5/TYW2 family.|||Cytoplasm|||Mitochondrion matrix|||Monomer.|||Nucleus|||Specifically methylates the N1 position of guanosine-37 in various cytoplasmic and mitochondrial tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. http://togogenome.org/gene/36329:PF3D7_1463700 ^@ http://purl.uniprot.org/uniprot/Q8IKK0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/36329:PF3D7_0216700.1 ^@ http://purl.uniprot.org/uniprot/Q8I659 ^@ Biotechnology|||Function|||Similarity ^@ Belongs to the ATG11 family.|||Involved in cytoplasm to vacuole transport (Cvt), pexophagy, mitophagy and nucleophagy. Works as scaffold proteins that recruit ATG proteins to the pre-autophagosome (PAS), the site of vesicle/autophagosome formation.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1342900 ^@ http://purl.uniprot.org/uniprot/C0H5G5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1470900 ^@ http://purl.uniprot.org/uniprot/Q8IKC9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0917900 ^@ http://purl.uniprot.org/uniprot/Q8I2X4 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/36329:PF3D7_0610000 ^@ http://purl.uniprot.org/uniprot/C6KSU7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/36329:PF3D7_0622800 ^@ http://purl.uniprot.org/uniprot/C6KT64 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0213900 ^@ http://purl.uniprot.org/uniprot/O96219 ^@ Similarity ^@ Belongs to the RPAP2 family. http://togogenome.org/gene/36329:PF3D7_1250700 ^@ http://purl.uniprot.org/uniprot/Q8I4S7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0703100 ^@ http://purl.uniprot.org/uniprot/Q8IC39 ^@ Similarity ^@ Belongs to the MIP18 family. http://togogenome.org/gene/36329:PF3D7_0107000.1 ^@ http://purl.uniprot.org/uniprot/Q8I272 ^@ Similarity ^@ Belongs to the centrin family. http://togogenome.org/gene/36329:PF3D7_0305000 ^@ http://purl.uniprot.org/uniprot/O97235 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Mitochondrion|||This protein may be expected to contain an N-terminal transit peptide but none has been predicted. http://togogenome.org/gene/36329:PF3D7_1232200 ^@ http://purl.uniprot.org/uniprot/Q8I5A0 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/36329:PF3D7_1451300 ^@ http://purl.uniprot.org/uniprot/Q8IKW3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1446600 ^@ http://purl.uniprot.org/uniprot/Q8IL07 ^@ Function|||Similarity ^@ Belongs to the centrin family.|||Plays a fundamental role in microtubule organizing center structure and function. Component of the infraciliary lattice (ICL) and the ciliary basal bodies. http://togogenome.org/gene/36329:PF3D7_0516800 ^@ http://purl.uniprot.org/uniprot/Q8I3U0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0506800 ^@ http://purl.uniprot.org/uniprot/Q8I434 ^@ Similarity ^@ Belongs to the TCF25 family. http://togogenome.org/gene/36329:PF3D7_1023200 ^@ http://purl.uniprot.org/uniprot/Q8IJH3 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/36329:PF3D7_1467500 ^@ http://purl.uniprot.org/uniprot/Q8IKG2 ^@ Similarity ^@ Belongs to the KIN17 family. http://togogenome.org/gene/36329:PF3D7_1129400 ^@ http://purl.uniprot.org/uniprot/Q8II69 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/36329:PF3D7_0422800 ^@ http://purl.uniprot.org/uniprot/C0H4C0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0417800 ^@ http://purl.uniprot.org/uniprot/Q8I1Q9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/36329:PF3D7_1338100 ^@ http://purl.uniprot.org/uniprot/A0A5K1K9F3 ^@ Similarity ^@ Belongs to the proteasome subunit S3 family. http://togogenome.org/gene/36329:PF3D7_1104800 ^@ http://purl.uniprot.org/uniprot/Q8IIV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0420100 ^@ http://purl.uniprot.org/uniprot/Q8I1N8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/36329:PF3D7_0629600 ^@ http://purl.uniprot.org/uniprot/C6KTD1 ^@ Similarity ^@ Belongs to the RRP7 family. http://togogenome.org/gene/36329:PF3D7_1360800 ^@ http://purl.uniprot.org/uniprot/Q76NL8 ^@ Cofactor|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M16 family.|||Binds 1 zinc ion per subunit.|||Does not require processing for targeting to the food vacuole or maturation.|||Expressed during the asexual blood stage; expression begins at the late ring, early trophozoite stage, increases in the mid-trophozoite stage, and persists throughout the schizont stage (at protein level).|||In the food vacuole, acts downstream of proteases plasmepsins PMI and PMII and falcipains during the catabolism of host hemoglobin by cleaving peptide fragments of alpha and beta hemoglobin subunits generated by PMI and PMII and falcipains (PubMed:17074076). In the apicoplast, degrades apicoplast transit peptides after their cleavage (PubMed:17074076). Prefers bulky hydrophobic amino acids in the P1' position at both acidic and neutral pH (By similarity). At P2', prefers hydrophobic residues at acidic pH; at neutral pH, these same residues are abundant but prefers Arg (By similarity). At P3', prefers hydrophobic residues, especially Met, at both pH conditions. At P4' and P5', prefers acidic residues at acidic pH, however, at neutral pH, the enzyme is less selective at these positions (By similarity). The optimal site cleavage at acidic pH is YNEHS-|-FFMEE and, at neutral pH, MKRHS-|-FRMRG (By similarity).|||Monomer.|||Vacuole membrane|||Vesicle|||apicoplast http://togogenome.org/gene/36329:PF3D7_0409200 ^@ http://purl.uniprot.org/uniprot/Q9U0J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1474500 ^@ http://purl.uniprot.org/uniprot/Q8IK93 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1018000 ^@ http://purl.uniprot.org/uniprot/Q8I715 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruB family. http://togogenome.org/gene/36329:PF3D7_1330400.1 ^@ http://purl.uniprot.org/uniprot/Q8IE22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1328100 ^@ http://purl.uniprot.org/uniprot/Q8I6T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_1424400 ^@ http://purl.uniprot.org/uniprot/Q8ILL2 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Component of the ribosome. http://togogenome.org/gene/36329:PF3D7_1442000 ^@ http://purl.uniprot.org/uniprot/Q8IL50 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/36329:PF3D7_1331800 ^@ http://purl.uniprot.org/uniprot/Q8IE09 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/36329:PF3D7_1132900 ^@ http://purl.uniprot.org/uniprot/Q8II35 ^@ Similarity ^@ Belongs to the GcvH family. http://togogenome.org/gene/36329:PF3D7_0214000 ^@ http://purl.uniprot.org/uniprot/O96220 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0210300 ^@ http://purl.uniprot.org/uniprot/O96186 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1333700 ^@ http://purl.uniprot.org/uniprot/Q8IDZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H3 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0904800 ^@ http://purl.uniprot.org/uniprot/Q8I3A1 ^@ Similarity ^@ Belongs to the replication factor A protein 1 family. http://togogenome.org/gene/36329:PF3D7_0108800 ^@ http://purl.uniprot.org/uniprot/Q8I254 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0613900 ^@ http://purl.uniprot.org/uniprot/C6KSY1 ^@ Caution|||Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_1408900 ^@ http://purl.uniprot.org/uniprot/Q8IM07 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/36329:PF3D7_0519300 ^@ http://purl.uniprot.org/uniprot/Q8I0W6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/36329:PF3D7_1226600 ^@ http://purl.uniprot.org/uniprot/Q7KQJ9 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PCNA family.|||Chromosome|||Cytoplasm|||Expressed during the asexual blood stage; expression is low at the ring stage, increases in trophozoites and early schizonts and sharply decreases in late schizonts (at protein level) (PubMed:12413950, PubMed:12464414, PubMed:26251451). Expressed during the sexual blood stage (PubMed:12464414).|||Homotrimer (PubMed:12413950, PubMed:12464414, PubMed:26251451). Oligomer (PubMed:12413950). Interacts with ORC1 (via PIP-box motif) (PubMed:26251451). Interacts with FEN1 (PubMed:26251451).|||Induced by DNA damage (at protein level).|||May be involved in DNA damage response (PubMed:26251451). Appears not to be involved in DNA replication in trophozoites (PubMed:26251451).|||Nucleus http://togogenome.org/gene/36329:PF3D7_1410000 ^@ http://purl.uniprot.org/uniprot/Q8ILZ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/36329:PF3D7_1469100 ^@ http://purl.uniprot.org/uniprot/Q8IKE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOSR1 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0616200 ^@ http://purl.uniprot.org/uniprot/C6KT03 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/36329:PF3D7_1458000 ^@ http://purl.uniprot.org/uniprot/Q8I6V0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_1213600 ^@ http://purl.uniprot.org/uniprot/Q8I5R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1127300 ^@ http://purl.uniprot.org/uniprot/Q8II90 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TrmB family.|||Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0624900 ^@ http://purl.uniprot.org/uniprot/C6KT85 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1462700 ^@ http://purl.uniprot.org/uniprot/Q8I6U9 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1020800 ^@ http://purl.uniprot.org/uniprot/Q8IJJ4 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1426100 ^@ http://purl.uniprot.org/uniprot/Q8ILK2 ^@ Similarity|||Subunit ^@ Belongs to the NAC-beta family.|||Part of the nascent polypeptide-associated complex (NAC). http://togogenome.org/gene/36329:PF3D7_1104000 ^@ http://purl.uniprot.org/uniprot/Q8IIW2 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/36329:PF3D7_0514600 ^@ http://purl.uniprot.org/uniprot/Q8I3W2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose 5-phosphate isomerase family.|||Homodimer.|||Involved in the first step of the non-oxidative branch of the pentose phosphate pathway. It catalyzes the reversible conversion of ribose-5-phosphate to ribulose 5-phosphate. http://togogenome.org/gene/36329:PF3D7_0714300 ^@ http://purl.uniprot.org/uniprot/Q8IBV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0109400 ^@ http://purl.uniprot.org/uniprot/Q8I250 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TBCA family.|||Supercomplex made of cofactors A to E. Cofactors A and D function by capturing and stabilizing tubulin in a quasi-native conformation. Cofactor E binds to the cofactor D-tubulin complex; interaction with cofactor C then causes the release of tubulin polypeptides that are committed to the native state.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1318800 ^@ http://purl.uniprot.org/uniprot/Q8IEC8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0423100 ^@ http://purl.uniprot.org/uniprot/Q8IFN5 ^@ Similarity ^@ Belongs to the adaptor complexes small subunit family. http://togogenome.org/gene/36329:PF3D7_0311700 ^@ http://purl.uniprot.org/uniprot/O77350 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/36329:PF3D7_1357200 ^@ http://purl.uniprot.org/uniprot/Q8IDD3 ^@ Function|||Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu). http://togogenome.org/gene/36329:PF3D7_1217900 ^@ http://purl.uniprot.org/uniprot/Q8I5M9 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/36329:PF3D7_1320800 ^@ http://purl.uniprot.org/uniprot/Q8IEA6 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/36329:PF3D7_1316600 ^@ http://purl.uniprot.org/uniprot/Q8IEE9 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/36329:PF3D7_1335400 ^@ http://purl.uniprot.org/uniprot/Q8IDX6 ^@ Biotechnology|||Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Does not affect merozoite invasion of host erythrocytes, either untreated or treated with neuraminidase, trypsin or chymotrypsin.|||During the asexual blood stage, binds to a chymotrypsin sensitive, neuraminidase and trypsin resistant receptor on the surface of the host erythrocyte (PubMed:21628513). Despite its binding capacity, appears to be dispensable for merozoite invasion of host erythrocytes (PubMed:12606570, PubMed:21698217).|||During the asexual blood stage, binds to a trypsin-resistant and chymotrypsin and neuraminidase sensitive receptor on the surface of the host erythrocyte.|||Expressed during parasite asexual blood stages, specifically at the late schizont stage prior to merozoite release and in free merozoites (at protein level).|||Forms a heterodimer composed of the 285 kDa and the 85 kDa forms.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Proteolytically processed into multiple fragments following schizont rupture (PubMed:21628513, PubMed:12228308, PubMed:21698217). In the mature schizont stage prior to merozoite release, full length RH2b is processed post-Golgi into C-terminal 285 kDa and N-terminal 85 kDa forms (PubMed:21628513, PubMed:21698217). During merozoite invasion of host erythrocytes, further processing occurs generating a 140 kDa C-terminal form (PubMed:21628513). At the same time, the C-terminal transmembrane region is probably cleaved, probably by a rhomboid protease, to shed all the different processed protein forms from the membrane leaving a transmembrane 7 kDa form on the merozoite surface (PubMed:21628513, PubMed:21698217).|||RH2a expression levels greatly vary between isolates; levels are high in isolates 3D7, T996, HB3, D10, 7G8, K1, Pf120 and W2mef, and undetectable in isolates MCAMP, FCB1, T994 and FCR3 (PubMed:12228308, PubMed:12606570). A similar variation in expression affects other reticulocyte-binding proteins such as RH2b and RH1 (PubMed:12228308, PubMed:12606570). The expression pattern of RH1, RH2a and RH2b allows the strain to use different invasion pathways to enter erythrocytes (Probable). This provides a mechanism of phenotypic variation to evade host immune responses and to adapt to the polymorphic nature of the erythrocyte receptors in human populations (Probable).|||Secreted|||rhoptry|||tight junction http://togogenome.org/gene/36329:PF3D7_1304200.1 ^@ http://purl.uniprot.org/uniprot/C0H599 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1107700 ^@ http://purl.uniprot.org/uniprot/Q8IIS5 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the pescadillo family.|||Expressed during the parasite blood stage, including in rings, trophozoites and schizonts (at protein level) (PubMed:14698441). Expression increases in trophozoites and schizonts (PubMed:14698441).|||Interacts with dual specificity protein phosphatase YVH1.|||Nucleus|||Required for maturation of ribosomal RNAs and formation of the large ribosomal subunit.|||nucleolus|||nucleoplasm http://togogenome.org/gene/36329:PF3D7_1344600 ^@ http://purl.uniprot.org/uniprot/Q8IDQ0 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Expressed maximally in the early stages and late stages of the parasite erythrocytic development.|||apicoplast http://togogenome.org/gene/36329:PF3D7_0814000 ^@ http://purl.uniprot.org/uniprot/Q8IAX6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/36329:PF3D7_1020500 ^@ http://purl.uniprot.org/uniprot/Q8IJJ7 ^@ Similarity ^@ Belongs to the Iojap/RsfS family. http://togogenome.org/gene/36329:PF3D7_1361900 ^@ http://purl.uniprot.org/uniprot/P61074 ^@ Developmental Stage|||Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Auxiliary protein of DNA polymerase delta and is involved in the control of DNA replication by increasing the polymerase processibility during elongation of the leading strand (By similarity). Involved in DNA damage response (PubMed:26251451).|||Belongs to the PCNA family.|||Chromosome|||Cytoplasm|||Expressed during the asexual blood stage, specifically during the trophozoite and schizont stages (at protein level).|||Homotrimer (PubMed:26251451, PubMed:30052905). Interacts with ORC1 (via PIP-box motif); the interaction occurs during DNA replication in trophozoites (PubMed:18554328, PubMed:26251451). Interacts with ORC5; the interaction occurs during the trophozoite stage but not at the late schizont stage (PubMed:18554328, PubMed:19633266, PubMed:26251451). Interacts with FEN1 (PubMed:26251451).|||Induced by DNA damage (at protein level).|||Nucleus http://togogenome.org/gene/36329:PF3D7_1353700 ^@ http://purl.uniprot.org/uniprot/Q8IDG4 ^@ Similarity ^@ Belongs to the MGR2 family. http://togogenome.org/gene/36329:PF3D7_0209100 ^@ http://purl.uniprot.org/uniprot/O96176 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0215700 ^@ http://purl.uniprot.org/uniprot/O96236 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1407300 ^@ http://purl.uniprot.org/uniprot/Q8IM21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1030500 ^@ http://purl.uniprot.org/uniprot/Q8IJA0 ^@ Similarity ^@ Belongs to the proteasome subunit S11 family. http://togogenome.org/gene/36329:PF3D7_1116800 ^@ http://purl.uniprot.org/uniprot/Q8IIJ8 ^@ Similarity ^@ Belongs to the ClpA/ClpB family. http://togogenome.org/gene/36329:PF3D7_1340900 ^@ http://purl.uniprot.org/uniprot/Q8IDS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/36329:PF3D7_1123800 ^@ http://purl.uniprot.org/uniprot/Q8IIC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1436000 ^@ http://purl.uniprot.org/uniprot/Q8ILA4 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/36329:PF3D7_1017900 ^@ http://purl.uniprot.org/uniprot/Q8IJM0 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/36329:PF3D7_1123100 ^@ http://purl.uniprot.org/uniprot/Q8IID2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. http://togogenome.org/gene/36329:PF3D7_1248600 ^@ http://purl.uniprot.org/uniprot/Q8I4U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGS family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1230900 ^@ http://purl.uniprot.org/uniprot/A0A144A2N6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/36329:PF3D7_1013600 ^@ http://purl.uniprot.org/uniprot/Q8IJQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0618300 ^@ http://purl.uniprot.org/uniprot/C6KT23 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/36329:PF3D7_0813800 ^@ http://purl.uniprot.org/uniprot/Q8IAX4 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/36329:PF3D7_0706400 ^@ http://purl.uniprot.org/uniprot/C0H4L5 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/36329:PF3D7_0722100 ^@ http://purl.uniprot.org/uniprot/Q8I6Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes and triggering endonucleolytic cleavage of the mRNA, a mechanism to release non-functional ribosomes and degrade damaged mRNAs.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1236700 ^@ http://purl.uniprot.org/uniprot/Q8I556 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. RsmH family. http://togogenome.org/gene/36329:PF3D7_1124400 ^@ http://purl.uniprot.org/uniprot/Q8IIB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Cytoplasm|||LSm subunits form a heteromer with a donut shape.|||P-body|||Probably involved with other LSm subunits in the general process of degradation of mRNAs. http://togogenome.org/gene/36329:PF3D7_1143100 ^@ http://purl.uniprot.org/uniprot/Q8IHT5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0512000 ^@ http://purl.uniprot.org/uniprot/Q8I3Y6 ^@ Biotechnology|||Function|||Similarity|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Binds specifically to cytosolic chaperonin (c-CPN) and transfers target proteins to it. Binds to nascent polypeptide chain and promotes folding in an environment in which there are many competing pathways for nonnative proteins (By similarity).|||Heterohexamer of two PFD-alpha type and four PFD-beta type subunits.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1105400 ^@ http://purl.uniprot.org/uniprot/Q8IIU8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/36329:PF3D7_1303900 ^@ http://purl.uniprot.org/uniprot/C0H597 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1358300 ^@ http://purl.uniprot.org/uniprot/A0A5K1K991 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1330000.1 ^@ http://purl.uniprot.org/uniprot/Q8IE26 ^@ Similarity ^@ Belongs to the PITHD1 family. http://togogenome.org/gene/36329:PF3D7_1120300 ^@ http://purl.uniprot.org/uniprot/Q8IIG4 ^@ Biotechnology|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Mitochondrial inner membrane magnesium transporter required for mitochondrial magnesium homeostasis (By similarity). Involved in the development of the sporozoite in the mosquito vector midgut (By similarity).|||Mitochondrion inner membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0609800 ^@ http://purl.uniprot.org/uniprot/C6KSU5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_0509200 ^@ http://purl.uniprot.org/uniprot/Q8I412 ^@ Similarity ^@ Belongs to the DNAAF1 family. http://togogenome.org/gene/36329:PF3D7_1434200 ^@ http://purl.uniprot.org/uniprot/P62203 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calmodulin family.|||Calmodulin is not involved in the mechanism of chloroquine resistance.|||Calmodulin mediates the control of a large number of enzymes, ion channels and other proteins by Ca(2+) (PubMed:32821880). Among the enzymes to be stimulated by the calmodulin-Ca(2+) complex are a number of protein kinases and phosphatases (PubMed:32821880).|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1430100 ^@ http://purl.uniprot.org/uniprot/Q8ILG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_0513300 ^@ http://purl.uniprot.org/uniprot/Q8I3X4 ^@ Activity Regulation|||Developmental Stage|||Disruption Phenotype|||Function|||Similarity|||Subunit ^@ As part of the purine salvage pathway, catalyzes the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate (PubMed:18957439, PubMed:14982926, PubMed:16131758, PubMed:19575810, PubMed:24416224, PubMed:29440412). Preferentially acts on inosine and guanosine, and to a lesser extent on 2'-deoxyguanosine and guanosine (PubMed:14982926, PubMed:16131758, PubMed:19575810). Also catalyzes the phosphorylation of S-methyl-5'-thioinosine (MTI) to hypoxanthine; MTI is produced by adenosine deaminase (ADA)-mediated breakdown of S-methyl-5'-thioadenosine (MTA), a major by-product of polyamine biosynthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Generates hypoxanthine from both the purine salvage pathway and from polyamine metabolism which is required for nucleic acids synthesis (PubMed:18957439, PubMed:14982926, PubMed:24416224). Has no activity towards adenosine (By similarity).|||Belongs to the PNP/MTAP phosphorylase family.|||Expressed during the parasite blood stage, including in trophozoites (at protein level).|||Homohexamer; trimer of homodimers.|||Inhibited by Immucillin-H and 5'-methylthio-Immucillin-H (PubMed:14982926, PubMed:24416224). Inhibited by 5'-deaza-1'-aza-2c-deoxy-1'-(9-methylene)-Immucilin-G (DADMe-ImmG) (PubMed:29440412).|||Severe growth defect in host erythrocytes which is rescued by the addition of exogenous purines (PubMed:18957439). Loss of purine nucleoside phosphorylase activity (PubMed:18957439). http://togogenome.org/gene/36329:PF3D7_0816900 ^@ http://purl.uniprot.org/uniprot/Q8IB06 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP (PubMed:18973776). Has very low activity with CTP, GTP, ITP and UTP and no activity with GMP, UMP or IMP in vitro (PubMed:18973776).|||May be palmitoylated at Cys-4 which stabilizes cell membrane localization of the myristoylated protein.|||Monomer (PubMed:18973776). Oligomer (PubMed:18973776). Heterodimer composed of NMT and AK2; AK2 myristoylation stabilizes the complex (PubMed:18973776).|||Myristoylation is required for cell membrane localization.|||Parasitophorous vacuole membrane http://togogenome.org/gene/36329:PF3D7_0935100 ^@ http://purl.uniprot.org/uniprot/C0H590 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KISH family.|||Golgi apparatus membrane|||Involved in the early part of the secretory pathway.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/36329:PF3D7_1411900 ^@ http://purl.uniprot.org/uniprot/Q8ILX6 ^@ Similarity ^@ Belongs to the nuclease type I family. http://togogenome.org/gene/36329:PF3D7_1443900 ^@ http://purl.uniprot.org/uniprot/Q8IL32 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/36329:PF3D7_1323000 ^@ http://purl.uniprot.org/uniprot/Q8I6T4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/36329:PF3D7_0110900 ^@ http://purl.uniprot.org/uniprot/Q8I236 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Has also ATPase activity.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1209200 ^@ http://purl.uniprot.org/uniprot/Q8I5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP Sm proteins family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0304400.1 ^@ http://purl.uniprot.org/uniprot/O97231 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Component of the large ribosomal subunit (PubMed:24913268, PubMed:26432834, PubMed:28288098). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28288098). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_0318900 ^@ http://purl.uniprot.org/uniprot/O77369 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1354300 ^@ http://purl.uniprot.org/uniprot/Q8IDF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. SPB1 subfamily.|||Probable methyltransferase involved in the maturation of rRNA and in the biogenesis of ribosomal subunits.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1337200 ^@ http://purl.uniprot.org/uniprot/Q8IDW0 ^@ Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1144000 ^@ http://purl.uniprot.org/uniprot/Q8IHS5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS21 family. http://togogenome.org/gene/36329:PF3D7_1126200 ^@ http://purl.uniprot.org/uniprot/Q8IIA2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS13 family. http://togogenome.org/gene/36329:PF3D7_1244000 ^@ http://purl.uniprot.org/uniprot/Q8I4Z0 ^@ Function ^@ Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/36329:PF3D7_1130600 ^@ http://purl.uniprot.org/uniprot/Q8II58 ^@ Function|||Similarity ^@ Belongs to the methyltransferase TRM13 family.|||tRNA methylase which 2'-O-methylates cytidine(4) in tRNA(Pro) and tRNA(Gly)(GCC), and adenosine(4) in tRNA(His). http://togogenome.org/gene/36329:PF3D7_1237200 ^@ http://purl.uniprot.org/uniprot/Q8I551 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP38 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1308900 ^@ http://purl.uniprot.org/uniprot/Q8IEM5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. DCP2 subfamily. http://togogenome.org/gene/36329:PF3D7_0822100 ^@ http://purl.uniprot.org/uniprot/Q8IB55 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0105800 ^@ http://purl.uniprot.org/uniprot/Q8I283 ^@ Function|||Similarity ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function. http://togogenome.org/gene/36329:PF3D7_0206600 ^@ http://purl.uniprot.org/uniprot/O96159 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0605200 ^@ http://purl.uniprot.org/uniprot/C6KSQ0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0415000 ^@ http://purl.uniprot.org/uniprot/Q8I1T8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase required for the post-translational delivery of tail-anchored (TA) proteins to the endoplasmic reticulum. Recognizes and selectively binds the transmembrane domain of TA proteins in the cytosol. This complex then targets to the endoplasmic reticulum by membrane-bound receptors, where the tail-anchored protein is released for insertion. This process is regulated by ATP binding and hydrolysis. ATP binding drives the homodimer towards the closed dimer state, facilitating recognition of newly synthesized TA membrane proteins. ATP hydrolysis is required for insertion. Subsequently, the homodimer reverts towards the open dimer state, lowering its affinity for the membrane-bound receptor, and returning it to the cytosol to initiate a new round of targeting.|||Belongs to the arsA ATPase family.|||Cytoplasm|||Endoplasmic reticulum|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1347700 ^@ http://purl.uniprot.org/uniprot/Q8IDM2 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/36329:PF3D7_0705700 ^@ http://purl.uniprot.org/uniprot/C0H4K8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/36329:PF3D7_0630500 ^@ http://purl.uniprot.org/uniprot/C6KTE0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_0907900 ^@ http://purl.uniprot.org/uniprot/Q8I372 ^@ Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. http://togogenome.org/gene/36329:PF3D7_0526900 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8K6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1020400 ^@ http://purl.uniprot.org/uniprot/Q8IJJ8 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0310100 ^@ http://purl.uniprot.org/uniprot/Q9NJU9 ^@ Activity Regulation|||Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Activated by calcium (Probable). Upon calcium binding to the EF-hand domain 2, the C-terminus of the junction domain (J domain) undergoes a conformational change which results in the dissociation of the pseudo-substrate inhibitory motif from the catalytic domain (Probable). This, in turn, may facilitate the autophosphorylation of the activation loop at Thr-279, which leads to the kinase activation (By similarity).|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily.|||Calcium-dependent protein kinase which acts as a sensor and effector of intracellular Ca(2+) levels probably in part downstream of cGMP-activated PKG kinase (By similarity). In the mosquito midgut, regulates the gliding motility of the ookinete which is essential for the ookinete to invade the midgut epithelium (By similarity). However, another study showed that while required for ookinete invasion of the midgut epithelium, is not required for ookinete gliding motility (By similarity).|||Cytoplasm|||Expressed in sexual stages, but not in asexual stages.|||The EF-hand domain 1 cannot bind calcium due to the presence of a Lys instead of an Asp at position 435 and a Gln instead of a Glu at position 442 preventing calcium binding (PubMed:28746405, PubMed:21287613). The EF-hand domains 3 and 4 probably bind calcium constitutively when calcium levels are low, while the EF-hand domain 2 binds calcium following an increase in calcium levels (PubMed:21287613).|||The junction domain (J domain) is composed of 2 motifs that maintain the kinase inactive. The N-terminal autoinhibitory motif acts as a pseudosubstrate inhibiting the catalytic domain while the C-terminal motif binds the EF-hand domains. http://togogenome.org/gene/36329:PF3D7_1250300 ^@ http://purl.uniprot.org/uniprot/Q8I4T1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the VPS26 family.|||Component of the retromer complex, composed of VPS26, VPS29 and VPS35 (PubMed:29654975). As part of the retromer complex, interacts with the sorting receptor SORTLR/sortilin (PubMed:29654975). Interacts with GTPase RAB7 (PubMed:32512169).|||Plays a role in vesicular protein sorting (By similarity). Component of the membrane-associated retromer complex which is essential in endosome-to-Golgi retrograde transport (By similarity). http://togogenome.org/gene/36329:PF3D7_1038100 ^@ http://purl.uniprot.org/uniprot/Q8IJ27 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/36329:PF3D7_1436800 ^@ http://purl.uniprot.org/uniprot/Q8IL98 ^@ Similarity ^@ Belongs to the peptidase S14 family. http://togogenome.org/gene/36329:PF3D7_1443600 ^@ http://purl.uniprot.org/uniprot/Q8IL35 ^@ Similarity ^@ Belongs to the TUBGCP family. http://togogenome.org/gene/36329:PF3D7_1436600 ^@ http://purl.uniprot.org/uniprot/Q8I719 ^@ Activity Regulation|||Developmental Stage|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by cGMP (PubMed:12068803, PubMed:12817987, PubMed:26149123, PubMed:29251493, PubMed:25646845, PubMed:31239348). Not activated by cAMP (PubMed:12068803, PubMed:12817987). cGMP binding allosterically triggers a conformational change at the alpha C-helix of cGMP-binding domain 4, which bridges the regulatory and catalytic domains, causing the capping triad, composed of Arg-484, Gln-532 and Asp-533, to form and stabilize the active conformation (PubMed:29251493, PubMed:25646845). The cGMP-binding domains acts cooperatively to activate PKG (PubMed:29251493, PubMed:12817987).|||Autophosphorylated.|||Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily.|||Cytoplasm|||Endoplasmic reticulum membrane|||Expressed during the parasite blood stage, expression is low at the ring stage and in early trophozoites, then increases during the parasite maturation to peak at the late schizont stage (at protein level) (PubMed:31239348, PubMed:19915077, PubMed:23139764, PubMed:12068803). Expression is low in gametocytes (at protein level) (PubMed:23139764).|||Monomer.|||Serine/threonine protein kinase which acts as a downstream effector of the second messenger cGMP (PubMed:12068803, PubMed:12817987, PubMed:26149123). Controls the release of Ca(2+) from intracellular stores by regulating phosphoinositide biosynthesis (PubMed:24594931). Ca(2+) signals are essential for merozoite and sporozoite invasion and egress from host hepatocytes and erythrocytes, and, in the mosquito vector, for gametocyte activation, and ookinete and sporozoite motility (PubMed:24594931). During the host liver stage, regulates the initial invasion of host hepatocytes by sporozoites by regulating sporozoite motility and microneme exocytosis (By similarity). Following parasite development in the hepatocytes, required for the release of merosomes, a vesicle containing the mature merozoites (By similarity). During the asexual blood stage, required for the progression from schizont to the ring stage following merozoite invasion of host erythrocytes and for merozoite egress (PubMed:19915077, PubMed:26149123, PubMed:25646845). Regulates merozoite egress by promoting the release of exonemes and micronemes which contain proteins essential for egress (PubMed:23675297). Phosphorylates CDPK1 predominantly at the late schizont stage; phosphorylation at 'Ser-64' regulates CDPK1 protein-protein interaction and phosphorylation at 'Thr-231' may regulate CDPK1 kinase activity (PubMed:26149123). Phosphorylates MyoA at 'Ser-19' (PubMed:26149123). In the mosquito vector, required for the initiation of gametogenesis induced by xanthurenic acid, specifically the gametocyte differentiation from the crescent-shaped form to the spherical form (PubMed:18532880). Required for the gliding motility of ookinetes to reach and penetrate the midgut epithelium by promoting Ca(2+)-mediated activation of CDPK1 and CDPK4 (By similarity). Also required for microneme secretion in ookinete by promoting Ca(2+)-mediated activation of CDPK3 (By similarity).|||The autoinhibitory segment (AIS) interacts with the active site and inhibits catalytic activity.|||The cNMP-binding domains 1, 2 and 4 bind preferentially cGMP (PubMed:25646845). The cNMP-binding domain 4 binds cGMP with the highest affinity and is highly selective for cGMP (PubMed:29251493, PubMed:25646845, PubMed:31239348). The cNMP-binding domain 3 does not bind cGMP but is required for cGMP-dependent catalytic activity (PubMed:12817987). The cNMP-binding domains 1, 2 and 4 can bind cAMP but with less affinity (PubMed:25646845). http://togogenome.org/gene/36329:PF3D7_0407700 ^@ http://purl.uniprot.org/uniprot/Q9U0K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0821500 ^@ http://purl.uniprot.org/uniprot/Q8IB49 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family. http://togogenome.org/gene/36329:PF3D7_0612100 ^@ http://purl.uniprot.org/uniprot/C6KSW5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1133400 ^@ http://purl.uniprot.org/uniprot/Q7KQK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the apicomplexan parasites AMA1 family.|||Involved in parasite invasion of erythrocytes.|||Membrane http://togogenome.org/gene/36329:PF3D7_1314900 ^@ http://purl.uniprot.org/uniprot/Q8IEG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0310700 ^@ http://purl.uniprot.org/uniprot/O77358 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/36329:PF3D7_1457500 ^@ http://purl.uniprot.org/uniprot/Q8IKQ5 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_1227200 ^@ http://purl.uniprot.org/uniprot/Q8I5E6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0317300 ^@ http://purl.uniprot.org/uniprot/O77384 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0503400 ^@ http://purl.uniprot.org/uniprot/Q8I467 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin-binding proteins ADF family.|||Cytoplasm|||Interacts with monomeric actin, does not bind to actin polymers.|||Not involved in actin polymerisation, instead functions to stimulate nucleotide exchange on monomeric actin and influence turnover of the small amount of cytosolic actin microfilaments. Essential for erythrocytic schizogony (By similarity).|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0719200 ^@ http://purl.uniprot.org/uniprot/C0H4N8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_0527100 ^@ http://purl.uniprot.org/uniprot/Q8I3J4 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/36329:PF3D7_1233300 ^@ http://purl.uniprot.org/uniprot/Q8I589 ^@ Biotechnology|||Similarity ^@ Belongs to the PPR family.|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1120600 ^@ http://purl.uniprot.org/uniprot/Q8IIG1 ^@ Biotechnology|||Developmental Stage|||Subcellular Location Annotation ^@ Expressed during the asexual cell-cycle on the cell surface of the host erythrocytes.|||Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0323700 ^@ http://purl.uniprot.org/uniprot/O97303 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNU66/SART1 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0506900 ^@ http://purl.uniprot.org/uniprot/Q8I433 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S54 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/36329:PF3D7_0913900 ^@ http://purl.uniprot.org/uniprot/Q8I313 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/36329:PF3D7_0922700 ^@ http://purl.uniprot.org/uniprot/Q8I2S9 ^@ Similarity ^@ Belongs to the PRP18 family. http://togogenome.org/gene/36329:PF3D7_1140100 ^@ http://purl.uniprot.org/uniprot/Q8IHW4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase F subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/36329:PF3D7_1412500 ^@ http://purl.uniprot.org/uniprot/Q8ILW9 ^@ Activity Regulation|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ACT1 and ACT2 differ in their polymerization, filament stability and helical structure. Unlike mammalian actin, Apicomplexa actins do not form long and stable filaments.|||ATP hydrolysis occurs in the polymeric state. Unlike for mammalian actin, ATP hydrolysis occurs also in the monomeric form and the release of inorganic phosphate (Pi) is more efficient.|||Actin is a highly conserved protein that polymerizes to produce filaments that form cross-linked networks in the cytoplasm. Polymerizes into longer and more stable actin filaments compared to ACT1/actin-1. Has ATPase activity. ATP hydrolysis leads to the formation of a stable intermediate ADP-inorganic phosphate (Pi) actin, which is followed by the release of Pi. ATP hydrolysis affects filament stability; ADP-bound actin depolymerizes much faster than ATP- or ADP-Pi-bound actin. Plays an essential role in male gametocyte development in the mosquito midgut, functioning in several processes including male gametocyte egress from host erythrocytes, formation of a beating flagellum and relocalization of ACT1/actin-1 to the cytoplasm. On the basal side of the mosquito midgut epithelium, required for the development of ookinetes into sporogonic oocysts.|||Belongs to the actin family.|||Cytoplasm|||Monomer (G-actin). Oligomer (F-actin). Polymerization of globular actin (G-actin) leads to a structural filament (F-actin) in the form of a two-stranded helix. Unlike for mammalian monomeric actin, monomeric actin is able to induce oligomerization with ATP or ADP. Mg(2+), which is used to coordinate ATP, is required for polymerization.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0629100 ^@ http://purl.uniprot.org/uniprot/C6KTC6 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/36329:PF3D7_1007700 ^@ http://purl.uniprot.org/uniprot/Q8IJW6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1365500 ^@ http://purl.uniprot.org/uniprot/Q8I6T0 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/36329:PF3D7_0827700 ^@ http://purl.uniprot.org/uniprot/Q8IBA9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0106900 ^@ http://purl.uniprot.org/uniprot/Q8I273 ^@ Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily. http://togogenome.org/gene/36329:PF3D7_1106800 ^@ http://purl.uniprot.org/uniprot/Q8IIT5 ^@ Caution|||Domain|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Although it belongs to the kinase superfamily, contains an asparagine residue at the position of the canonical catalytic aspartic acid and does not have kinase activity (PubMed:31148576). However, can bind ATP (PubMed:31148576).|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family.|||Host cell membrane|||Host cytoplasm|||Interacts (via RVxF motif 1 and/or 2) with phosphatase PP1C (PubMed:31148576). May interact (via SAM domain) with SERA5 (via C-terminus) (PubMed:31148576).|||Parasitophorous vacuole|||The protein kinase domain is predicted to be catalytically inactive (By similarity). There is a second N-terminal lobe-like kinase domain at residues 830-1095 that contains functional ATP binding sites (PubMed:31148576).|||host cytoskeleton http://togogenome.org/gene/36329:PF3D7_1332600 ^@ http://purl.uniprot.org/uniprot/Q8IE02 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Apurinic/apyrimidinic (AP) endonuclease activity is enhanced with increasing concentrations of Mn(2+), while Zn(2+) initially enhances activity but subsequently inhibits activity in a concentration-dependent manner (PubMed:31386260). Co(2+) inhibits apurinic/apyrimidinic (AP) endonuclease activity at concentrations greater than 2.5 mM (PubMed:31386260).|||Belongs to the AP endonuclease 2 family.|||Binds 2 Zn(2+) and 1 Mn(2+) ions.|||Expressed during the asexual blood stage (at protein level).|||May be proteolytically cleaved into a 59 kDa form.|||Mitochondrion|||Plays a role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress (PubMed:31386260). Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) with a preference for C as opposite base (PubMed:31386260). Has 3'-phosphatase activity; removes 3'-phosphate from blunt-end, recessed, and gapped DNA templates and thus, removes 3'-blocks for DNA polymerase activity during BER (PubMed:31386260). Lacks 3'-5' exonuclease activity and does not cleave damaged bases by nucleotide incision repair (NIR) (PubMed:31386260). http://togogenome.org/gene/36329:PF3D7_0320500 ^@ http://purl.uniprot.org/uniprot/O97284 ^@ Similarity ^@ Belongs to the isochorismatase family. http://togogenome.org/gene/36329:PF3D7_1251300 ^@ http://purl.uniprot.org/uniprot/Q8I4S1 ^@ Activity Regulation|||Biotechnology|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate kinase family.|||Catalyzes the phosphorylation of thymidine monophosphate (dTMP) to thymidine diphosphate (dTDP), the immediate precursor for the DNA building block dTTP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can also phosphorylate dGMP and to a lesser extent GMP, dUMP and dIMP (PubMed:18477629, PubMed:19126267, PubMed:31934749, PubMed:20353400). Can use either ATP or dATP as phosphate donors in presence of Mg(2+) (PubMed:18477629).|||Homodimer (PubMed:18477629, PubMed:19126267, PubMed:31934749). Binds two dTMP molecules per dimer (PubMed:31934749). Binds only one dTGP molecule per dimer (PubMed:31934749).|||Inhibited by deoxyguanosine (dG), deoxythymidine (dT) and azidothymidine (AZT).|||Phosphorylates AZT monophosphate (AZT-MP) more efficiently than human DTYMK/TMPK. The conversion of AZT MP into AZT diphosphate (AZT-DP) by the human enzyme is a crucial step in the production of the active anti-HIV drug AZT triphosphate (AZT-TP). http://togogenome.org/gene/36329:PF3D7_0625100 ^@ http://purl.uniprot.org/uniprot/C6KT87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1412800 ^@ http://purl.uniprot.org/uniprot/Q8ILW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins (By similarity). Myristoylates adenylate kinase AK2 (By similarity). During the asexual blood stage, may myristoylate proteins such as ARO, CDPK1 and GAP45 (PubMed:34695132). Probably by mediating protein myristoylation, plays a role in the assembly of the inner membrane complex during the early stages of schizogony and in the formation of rhoptries in the late stages and thus merozoite egress (PubMed:34695132).|||Belongs to the NMT family.|||Cytoplasm|||Heterodimer composed of NMT and AK2; AK2 myristoylation stabilizes the complex. http://togogenome.org/gene/36329:PF3D7_1209600 ^@ http://purl.uniprot.org/uniprot/Q8I5V3 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/36329:PF3D7_0522300 ^@ http://purl.uniprot.org/uniprot/C0H4F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. BUD23/WBSCR22 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0206200 ^@ http://purl.uniprot.org/uniprot/O96156 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1471400 ^@ http://purl.uniprot.org/uniprot/Q8IKC5 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/36329:PF3D7_1458700 ^@ http://purl.uniprot.org/uniprot/Q8IKP4 ^@ Similarity ^@ Belongs to the EXO5 family. http://togogenome.org/gene/36329:PF3D7_0404900 ^@ http://purl.uniprot.org/uniprot/Q8I1Y0 ^@ Developmental Stage|||Disruption Phenotype|||Miscellaneous|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell surface|||Does not have erythrocyte-receptor-binding ability.|||Heterodimer; heterodimerizes with PF12. May form an antiparallel heterodimer with PF12.|||No visible phenotype. Parasites grow at normal rates in vitro.|||Processed into a soluble form.|||Specifically present in asexual blood stage parasites. First detected in the trophozoite stage, 30-40 hours post-invasion (HPI) and the proteins reaches peak expression in schizont stage, 40-48 HPI. http://togogenome.org/gene/36329:PF3D7_1242800 ^@ http://purl.uniprot.org/uniprot/Q8I501 ^@ Similarity ^@ Belongs to the Rab GDI family. http://togogenome.org/gene/36329:PF3D7_0926400 ^@ http://purl.uniprot.org/uniprot/C0H564 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1452700 ^@ http://purl.uniprot.org/uniprot/Q8IKU9 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/36329:PF3D7_1311900 ^@ http://purl.uniprot.org/uniprot/Q76NM6 ^@ Activity Regulation|||Biotechnology|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP hydrolysis occurs at the interface between the nucleotide-binding domains of subunits A and B (By similarity). ATP hydrolysis triggers a conformational change in the subunits D and F, which induces a shift of subunit d (By similarity). The c-ring is subsequently rotated and results in a continuous proton translocation across the membrane (By similarity).|||Belongs to the ATPase alpha/beta chains family.|||Catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (PubMed:10915784). During the trophozoite stage, involved in the acidification of the extracellular space next to the cell membrane (PubMed:10915784).|||Cell membrane|||Expressed during the asexual blood stage, including in trophozoites (at protein level).|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex (By similarity). The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H (By similarity). The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d and subunit e (By similarity).|||Vacuole|||Vesicle http://togogenome.org/gene/36329:PF3D7_1321800 ^@ http://purl.uniprot.org/uniprot/Q8IE98 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SFT2 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May be involved in fusion of retrograde transport vesicles derived from an endocytic compartment with the Golgi complex.|||Membrane http://togogenome.org/gene/36329:PF3D7_0320300 ^@ http://purl.uniprot.org/uniprot/O97282 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1347800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K981 ^@ Similarity ^@ Belongs to the DNAAF1 family. http://togogenome.org/gene/36329:PF3D7_0321200 ^@ http://purl.uniprot.org/uniprot/O97321 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0603500 ^@ http://purl.uniprot.org/uniprot/C6KSN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1467400 ^@ http://purl.uniprot.org/uniprot/Q8IKG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/36329:PF3D7_0623300 ^@ http://purl.uniprot.org/uniprot/C6KT69 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/36329:PF3D7_0531200 ^@ http://purl.uniprot.org/uniprot/Q8I3F6 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/36329:PF3D7_0726900 ^@ http://purl.uniprot.org/uniprot/Q8IBI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TIM50 family.|||Component of the TIM23 complex.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_0804800 ^@ http://purl.uniprot.org/uniprot/Q8I6S4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_1012000 ^@ http://purl.uniprot.org/uniprot/Q8IJS5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1456800 ^@ http://purl.uniprot.org/uniprot/Q8IKR1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1469700 ^@ http://purl.uniprot.org/uniprot/Q8IKE0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 6 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1342600 ^@ http://purl.uniprot.org/uniprot/Q8IDR3 ^@ Developmental Stage|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||Cell membrane|||Expressed during the parasite blood stage (at protein level).|||Interacts with ACT1.|||Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments (By similarity).|||This protein differs from the typical myosin heavy chain structure in having head and tail domains but no discernible neck domain. http://togogenome.org/gene/36329:PF3D7_0204900 ^@ http://purl.uniprot.org/uniprot/O96145 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/36329:PF3D7_1142400 ^@ http://purl.uniprot.org/uniprot/Q8IHU1 ^@ Similarity|||Subunit ^@ Belongs to the aerobic coproporphyrinogen-III oxidase family.|||Homodimer. http://togogenome.org/gene/36329:PF3D7_1340300 ^@ http://purl.uniprot.org/uniprot/Q8IDT3 ^@ Similarity ^@ Belongs to the NOC2 family. http://togogenome.org/gene/36329:PF3D7_0316500 ^@ http://purl.uniprot.org/uniprot/O77390 ^@ Similarity ^@ Belongs to the NUF2 family. http://togogenome.org/gene/36329:PF3D7_0910100 ^@ http://purl.uniprot.org/uniprot/C0H530 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1465700 ^@ http://purl.uniprot.org/uniprot/Q8IKI0 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/36329:PF3D7_1136900 ^@ http://purl.uniprot.org/uniprot/Q8IHZ5 ^@ Activity Regulation|||Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Activation may be calcium-dependent (PubMed:16879884). Inhibited by the non-covalent interaction with the cleaved propeptide (PubMed:16879884, PubMed:19214190).|||Belongs to the peptidase S8 family.|||Cell membrane|||Proteolytically cleaved at the N-terminus to generate a 74kDa intermediate which is further processed into a 72kDa form (PubMed:23834729). The first maturation cleavage is autocatalytic, occurs in the ER and is necessary for the subsequent SUB2 trafficking to the microneme (PubMed:23834729). The second cleavage may be mediated by PMX/plasmepsin X (PubMed:32109369).|||Serine protease which plays an essential role in the shedding of AMA1, MSP1 and MSP7 from the surface of the invading merozoite; this step is essential for productive invasion and the release of the adhesion between the erythrocyte and the merozoite (PubMed:16879884, PubMed:19214190). May cleave TRAMP/PTTRAMP, thereby shedding TRAMP from the merozoite surface during erythrocyte invasion (PubMed:16879884).|||The cytoplasmic domain is required for the correct redistribution at the merozoite surface and posterior capping but is dispensable for its progression through the secretory pathway.|||The propeptide domain acts as an intramolecular chaperone for the folding of the catalytic domain (By similarity). Also acts as an inhibitor of the catalytic domain thereby regulating SUB2 activity during secretion (PubMed:16879884, PubMed:19214190).|||The transmembrane domain is required for SUB2 progression through the secretory pathway.|||microneme membrane http://togogenome.org/gene/36329:PF3D7_1417800 ^@ http://purl.uniprot.org/uniprot/Q8ILR7 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/36329:PF3D7_1347200 ^@ http://purl.uniprot.org/uniprot/Q8IDM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1147500 ^@ http://purl.uniprot.org/uniprot/Q8IHP6 ^@ Similarity ^@ Belongs to the protein prenyltransferase subunit beta family. http://togogenome.org/gene/36329:PF3D7_0618600 ^@ http://purl.uniprot.org/uniprot/C6KT26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_0825500 ^@ http://purl.uniprot.org/uniprot/Q8IB88 ^@ Similarity ^@ Belongs to the KRI1 family. http://togogenome.org/gene/36329:PF3D7_0808400 ^@ http://purl.uniprot.org/uniprot/C0H4T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COPE family.|||Cytoplasm|||Membrane http://togogenome.org/gene/36329:PF3D7_0727200 ^@ http://purl.uniprot.org/uniprot/Q8IBI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0106700 ^@ http://purl.uniprot.org/uniprot/Q8I275 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_0618500 ^@ http://purl.uniprot.org/uniprot/C6KT25 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/36329:PF3D7_1335500 ^@ http://purl.uniprot.org/uniprot/C0H5F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS2/PSF2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0416300 ^@ http://purl.uniprot.org/uniprot/Q8I1S4 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/36329:PF3D7_0614800 ^@ http://purl.uniprot.org/uniprot/C6KSY9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nth/MutY family.|||Bifunctional DNA N-glycosylase with associated apurinic/apyrimidinic (AP) lyase function that catalyzes the first step in base excision repair (BER), the primary repair pathway for the repair of oxidative DNA damage. The DNA N-glycosylase activity releases the damaged DNA base from DNA by cleaving the N-glycosidic bond, leaving an AP site. The AP lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination. Primarily recognizes and repairs oxidative base damage of pyrimidines.|||Binds 1 [4Fe-4S] cluster. The cluster does not appear to play a role in catalysis, but is probably involved in the proper positioning of the enzyme along the DNA strand.|||Mitochondrion|||Nucleus http://togogenome.org/gene/36329:PF3D7_1329100 ^@ http://purl.uniprot.org/uniprot/Q8IE50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_1134700 ^@ http://purl.uniprot.org/uniprot/Q8II17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||In plastids the minimal PEP RNA polymerase catalytic core is composed of four subunits: alpha, beta, beta', and beta''. When a (nuclear-encoded) sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||apicoplast http://togogenome.org/gene/36329:PF3D7_1431700 ^@ http://purl.uniprot.org/uniprot/Q8ILE8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/36329:PF3D7_0217100 ^@ http://purl.uniprot.org/uniprot/O96252 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/36329:PF3D7_1412300 ^@ http://purl.uniprot.org/uniprot/Q8ILX1 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0612600 ^@ http://purl.uniprot.org/uniprot/C6KSW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TtcA family. CTU1/NCS6/ATPBD3 subfamily.|||Cytoplasm|||Plays a central role in 2-thiolation of mcm(5)S(2)U at tRNA wobble positions of tRNA(Lys), tRNA(Glu) and tRNA(Gln). Directly binds tRNAs and probably acts by catalyzing adenylation of tRNAs, an intermediate required for 2-thiolation. It is unclear whether it acts as a sulfurtransferase that transfers sulfur from thiocarboxylated URM1 onto the uridine of tRNAs at wobble position. http://togogenome.org/gene/36329:PF3D7_0818200 ^@ http://purl.uniprot.org/uniprot/C0H4V6 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adapter protein which binds to its partners, usually via a phosphoserine or phosphothreonine motif (PubMed:23308157, PubMed:32484216, PubMed:32817103). Binding generally results in the modulation of the activity and/or cellular localization of the binding partner (Probable). Via its interaction with CDPK1 and PKAr, involved in merozoite microneme secretion and thus in merozoite invasion of host erythrocytes (PubMed:32817103).|||Belongs to the 14-3-3 family.|||Cell membrane|||Cytoplasm|||Expressed during parasite asexual blood stages, at the ring, trophozoite and schizont stages and in free merozoites (at protein level).|||Homodimer (Probable). Forms a complex composed of CDPK1, PKA regulatory subunit PKAr and 14-3-3I; the complex is formed in merozoites in response to low extracellular level of K(+) and may play a role in microneme secretion (PubMed:32817103). Interacts with CDPK1 (when phosphorylated) in a Ca(2+)-independent manner; the interaction does not regulate CDPK1 catalytic activity but is required for merozoite invasion of host erythrocytes (PubMed:32484216, PubMed:32817103). Interacts with PKA regulatory subunit PKAr (when phosphorylated) in a Ca(2+)-dependent manner (PubMed:32817103). Interacts with histone H3 (when phosphorylated at 'Ser-28' or when phosphorylated at 'Ser-28' and 'Ser-32') (PubMed:23308157).|||Nucleus http://togogenome.org/gene/36329:PF3D7_1239900 ^@ http://purl.uniprot.org/uniprot/Q8I524 ^@ Similarity ^@ Belongs to the VPS16 family. http://togogenome.org/gene/36329:PF3D7_1144300 ^@ http://purl.uniprot.org/uniprot/C6S3G4 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL41 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/36329:PF3D7_0106100 ^@ http://purl.uniprot.org/uniprot/Q8I280 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme composed of a peripheral catalytic V1 complex (components A to H) attached to an integral membrane V0 proton pore complex. http://togogenome.org/gene/36329:PF3D7_0623600 ^@ http://purl.uniprot.org/uniprot/C6KT72 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BBP/SF1 family.|||Necessary for the splicing of pre-mRNA. Has a role in the recognition of the branch site (5'-UACUAAC-3'), the pyrimidine tract and the 3'-splice site at the 3'-end of introns.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0310600.1 ^@ http://purl.uniprot.org/uniprot/Q9NFE6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit K family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0908700 ^@ http://purl.uniprot.org/uniprot/Q8I0W4 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/36329:PF3D7_0924700 ^@ http://purl.uniprot.org/uniprot/Q8I2R0 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/36329:PF3D7_1124700 ^@ http://purl.uniprot.org/uniprot/Q8IIB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GrpE family.|||Essential component of the PAM complex, a complex required for the translocation of transit peptide-containing proteins from the inner membrane into the mitochondrial matrix in an ATP-dependent manner.|||Mitochondrion matrix http://togogenome.org/gene/36329:PF3D7_0629800 ^@ http://purl.uniprot.org/uniprot/C6KTD3 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/36329:PF3D7_0932600 ^@ http://purl.uniprot.org/uniprot/Q8I2J0 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/36329:PF3D7_1362300 ^@ http://purl.uniprot.org/uniprot/Q8ID84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0206800 ^@ http://purl.uniprot.org/uniprot/P50498 ^@ Biotechnology|||Developmental Stage|||Domain|||Function|||Polymorphism|||Subcellular Location Annotation ^@ Cell membrane|||Expressed during the asexual blood stage, including at the schizont stage and in free merozoites (at protein level).|||May play a role in the merozoite attachment to the erythrocyte.|||Potential candidate for the development of parasite blood stage vaccines (PubMed:19428875, PubMed:28189425). In vivo, induces antibodies capable of inhibiting parasite growth in the host (PubMed:19428875). In vitro, antibodies to MSP2 do not appear to inhibit invasion directly but may function to opsonize merozoites and promote antibody-dependent cellular inhibition mediated by host monocytes (PubMed:19428875, PubMed:24218484). The ability of merozoites to carry antibodies bound to MSP2 into the invaded host erythrocyte without apparent disruption of invasion or growth may represent an adaption of the parasite to render antibodies to the merozoite surface non-functional, thereby contributing to immune evasion (PubMed:24218484).|||The N-terminal region appears to be involved in lipid binding.|||The sequence varies across Plasmodium strains (PubMed:2181307). All variants share conserved N- and C-terminal regions; however, they belong to two allelic families, represented by 3D7 strain and FC27 strain sequences respectively, distinguished by tandem repeats and dimorphic flanking sequences within the central region of the protein (PubMed:2181307). http://togogenome.org/gene/36329:PF3D7_1137300 ^@ http://purl.uniprot.org/uniprot/Q8IHZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0714100 ^@ http://purl.uniprot.org/uniprot/Q8IBV6 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/36329:PF3D7_1007100 ^@ http://purl.uniprot.org/uniprot/C6S3C4 ^@ Similarity ^@ Belongs to the GAMAD family. http://togogenome.org/gene/36329:PF3D7_1223900 ^@ http://purl.uniprot.org/uniprot/Q8I5H8 ^@ Function|||Subunit ^@ One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/36329:PF3D7_1353300 ^@ http://purl.uniprot.org/uniprot/Q8IDG7 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0416800 ^@ http://purl.uniprot.org/uniprot/Q8I1S0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/36329:PF3D7_0109850 ^@ http://purl.uniprot.org/uniprot/B9ZSI8 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/36329:PF3D7_0910900 ^@ http://purl.uniprot.org/uniprot/C0H531 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||DNA primase is the polymerase that synthesizes small RNA primers for the Okazaki fragments made during discontinuous DNA replication. http://togogenome.org/gene/36329:PF3D7_1463800 ^@ http://purl.uniprot.org/uniprot/Q8IKJ9 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/36329:PF3D7_1441200 ^@ http://purl.uniprot.org/uniprot/Q8IL58 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL1 family. http://togogenome.org/gene/36329:PF3D7_0909500 ^@ http://purl.uniprot.org/uniprot/Q8I357 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/36329:PF3D7_1012700 ^@ http://purl.uniprot.org/uniprot/Q8IJR8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0415600 ^@ http://purl.uniprot.org/uniprot/Q8I1T1 ^@ Activity Regulation|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between GTP and AMP (PubMed:15478799). Has very low activity with UTP, ITP, CTP and IMP and no activity with ATP, GMP, CMP and UMP in vitro (PubMed:15478799).|||Inhibited by the dinucleoside pentaphosphate compound P1,P5-di(guanosine-5') pentaphosphate (GP5A).|||Mitochondrion|||There is a putative zinc finger domain which may bind to iron. http://togogenome.org/gene/36329:PF3D7_1344800 ^@ http://purl.uniprot.org/uniprot/A0A5K1K910 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. http://togogenome.org/gene/36329:PF3D7_0411300 ^@ http://purl.uniprot.org/uniprot/Q9U0H5 ^@ Similarity ^@ Belongs to the GOLGA6 family. http://togogenome.org/gene/36329:PF3D7_1015700.1 ^@ http://purl.uniprot.org/uniprot/C6S3C6 ^@ Similarity ^@ Belongs to the TBCC family. http://togogenome.org/gene/36329:PF3D7_0910500 ^@ http://purl.uniprot.org/uniprot/Q8I347 ^@ Similarity ^@ Belongs to the DNA polymerase type-Y family. http://togogenome.org/gene/36329:PF3D7_0208900 ^@ http://purl.uniprot.org/uniprot/O96175 ^@ Developmental Stage|||Function|||Miscellaneous|||Subcellular Location Annotation ^@ Cell membrane|||Cell surface|||In P.berghei, dispensable for male gamete attachment to erythrocytes and the formation of exflagellation centers.|||Plays an essential role in male gamete fertility (By similarity). Required for the binding to erythrocytes and thus, for the formation of exflagellation centers (By similarity).|||Specifically presents on the surface of stage V male gametocytes (at protein level) (PubMed:12106866, PubMed:30297725). Not expressed in gametes or asexual parasites (PubMed:12106866). Expression peaks in stage III/IV gametocytes, then sharply declines in gametes (PubMed:12106866). http://togogenome.org/gene/36329:PF3D7_0630300 ^@ http://purl.uniprot.org/uniprot/C6KTD8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/36329:PF3D7_1429200 ^@ http://purl.uniprot.org/uniprot/Q8ILH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1245100 ^@ http://purl.uniprot.org/uniprot/Q8I4Y0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_0301700 ^@ http://purl.uniprot.org/uniprot/O97336 ^@ Developmental Stage|||Disruption Phenotype|||Domain|||Function|||Subcellular Location Annotation|||Subunit ^@ At the asexual blood stage, causes an accumulation of vesicles at the Maurer's clefts (PubMed:35930605). Aberrant knob morphology and distribution; knobs are fewer and larger (PubMed:35930605). EMP1 delivery to the Maurer's clefts is normal; however, EMP1 delivery to the host erythrocyte cell surface is abolished (PubMed:35930605).|||During the asexual blood stage, plays an essential role in the recruitment and/or formation of EMP1-containing vesicles at the Maurer's clefts and their subsequent transfer to the host erythrocyte cell membrane.|||Expressed during the asexual blood stage, including rings and trophozoites (at protein level).|||Host cytoplasm|||May interact with MESA (PubMed:35930605). May interact with J-dot compartment protein PF3D7_0801000 (PubMed:35930605).|||Membrane|||The P.falciparum Export Element (PEXEL) motif, also known as the vacuolar transport signal (VTS), is a pentameric sequence (RxLxE/Q/D) required for the translocation of proteins across the parasitophorous vacuole membrane (Probable). In the endoplasmic reticulum, the motif is cleaved after the leucine residue and the N-terminus is N-acetylated (By similarity).|||Vesicle http://togogenome.org/gene/36329:PF3D7_0308500 ^@ http://purl.uniprot.org/uniprot/O97256 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/36329:PF3D7_0209000 ^@ http://purl.uniprot.org/uniprot/P68874 ^@ Biotechnology|||Developmental Stage|||Function|||PTM|||Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Cell surface|||Gametocyte surface protein required for male/female gamete fusion. Also required for male gamete exflagellation and interaction with host erythrocytes.|||Heterodimer; heterodimerizes with PF45/48.|||May be processed into a 310 kDa form as the parasite emerges from the host erythrocytes.|||Promising transmission-blocking vaccine candidate: targeting the protein would prevents transmission of the parasite decreasing the malaria burden (PubMed:32709983, PubMed:33741942). The LMIV230-01 transmission-blocking antibody against the 6-Cys domain 1 also binds to the heterologous P.falciparum Malian isolate 20-2217-0 which carries a 'Ser-605' polymorphism and to the heterologous St Lucia strain which carries 'Ser-605' and 'Asn-661' polymorphisms (PubMed:33741942).|||Specifically expressed in gametocytes and gametes (at protein level). http://togogenome.org/gene/36329:PF3D7_1422900 ^@ http://purl.uniprot.org/uniprot/Q8ILM3 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/36329:PF3D7_0217300 ^@ http://purl.uniprot.org/uniprot/O96254 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cell membrane|||coated pit http://togogenome.org/gene/36329:PF3D7_1213700 ^@ http://purl.uniprot.org/uniprot/Q8I5R8 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/36329:PF3D7_1402300 ^@ http://purl.uniprot.org/uniprot/Q8IM66 ^@ Similarity ^@ Belongs to the proteasome subunit S9 family. http://togogenome.org/gene/36329:PF3D7_1247300 ^@ http://purl.uniprot.org/uniprot/Q8I4V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGV family.|||Endoplasmic reticulum membrane|||Mannosyltransferase involved in glycosylphosphatidylinositol-anchor biosynthesis.|||Membrane http://togogenome.org/gene/36329:PF3D7_0628100 ^@ http://purl.uniprot.org/uniprot/C6KTB7 ^@ Biotechnology|||Function|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera.|||Putative E3 ubiquitin-protein ligase. http://togogenome.org/gene/36329:PF3D7_0905800 ^@ http://purl.uniprot.org/uniprot/Q8I391 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0509000 ^@ http://purl.uniprot.org/uniprot/Q8I0X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/36329:PF3D7_1242700 ^@ http://purl.uniprot.org/uniprot/Q8I502 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/36329:PF3D7_1455400 ^@ http://purl.uniprot.org/uniprot/Q8IKS4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1311800 ^@ http://purl.uniprot.org/uniprot/Q8IEK1 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/36329:PF3D7_1246600 ^@ http://purl.uniprot.org/uniprot/Q8I4W6 ^@ Similarity ^@ Belongs to the CWC26 family. http://togogenome.org/gene/36329:PF3D7_0204700 ^@ http://purl.uniprot.org/uniprot/Q7KWJ5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/36329:PF3D7_1015100 ^@ http://purl.uniprot.org/uniprot/Q8IJP4 ^@ Similarity ^@ Belongs to the CWC16 family. http://togogenome.org/gene/36329:PF3D7_1406400 ^@ http://purl.uniprot.org/uniprot/Q8IM30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPR family. P subfamily.|||Binds to apicoplast RNA transcripts, preferentially to the motif UUAU, and protects RNA transcripts from degradation by ribonuclease.|||Homodimer.|||apicoplast http://togogenome.org/gene/36329:PF3D7_0106400 ^@ http://purl.uniprot.org/uniprot/Q8I278 ^@ Similarity ^@ Belongs to the TSR2 family. http://togogenome.org/gene/36329:PF3D7_0911700 ^@ http://purl.uniprot.org/uniprot/Q8I335 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner (By similarity). http://togogenome.org/gene/36329:PF3D7_1322100 ^@ http://purl.uniprot.org/uniprot/Q8IE95 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Chromosome|||Highly expressed in early trophozoite stages. Expression is then reduced in late trophozoites and elevated again in schizonts.|||Histone methyltransferase that specifically represses expression of the surface antigen-coding var genes by mediating trimethylation of 'Lys-36' of histone H3 (H3K36me3) on var genes. SETVS-dependent H3K36me3 is specifically involved in var genes silencing, a central step malaria pathogenesis: each parasite contains 60 distinct var genes that each code for a different PfEMP1 protein. During infection, the clonal parasite population expresses only 1 gene at a time, while the 59 other var genes are silenced. The parasite then switches to the expression of a new variant antigen as an immune-evasion mechanism to avoid the host antibody response. Represses expression of both var mRNA and antisense long non-coding RNA.|||Leads to expression of all var genes in the ring stage.|||Nucleus|||Parasites lacking SETVS could be used as an antimalarial vaccine because of its ability to express all PfEMP1 proteins, to which the antibody would provide efficient protective immunity against malaria. http://togogenome.org/gene/36329:PF3D7_0722400 ^@ http://purl.uniprot.org/uniprot/Q8IBM9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer. http://togogenome.org/gene/36329:PF3D7_1413800 ^@ http://purl.uniprot.org/uniprot/Q8ILV7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. http://togogenome.org/gene/36329:PF3D7_1204300 ^@ http://purl.uniprot.org/uniprot/Q8I603 ^@ Function|||PTM|||Similarity ^@ Belongs to the eIF-5A family.|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/36329:PF3D7_1404800 ^@ http://purl.uniprot.org/uniprot/Q8IM46 ^@ Biotechnology ^@ Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_0706700 ^@ http://purl.uniprot.org/uniprot/C0H4L8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1318100 ^@ http://purl.uniprot.org/uniprot/Q8IED5 ^@ Cofactor|||Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 2Fe2S plant-type ferredoxin family.|||Binds 1 2Fe-2S cluster.|||Detected in trophozoite and schizont stages (at protein level).|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions (PubMed:16289098). By transferring electrons to 4-hydroxy-3-methylbut-2-enyl diphosphate reductase LytB/IspH, plays a role in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis (PubMed:16289098).|||apicoplast http://togogenome.org/gene/36329:PF3D7_1443500 ^@ http://purl.uniprot.org/uniprot/Q8IL36 ^@ Similarity ^@ Belongs to the CAF1 family. http://togogenome.org/gene/36329:PF3D7_0205900 ^@ http://purl.uniprot.org/uniprot/O96153 ^@ Similarity ^@ Belongs to the proteasome subunit S2 family. http://togogenome.org/gene/36329:PF3D7_1456100 ^@ http://purl.uniprot.org/uniprot/Q8IKR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SHMT family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0621500 ^@ http://purl.uniprot.org/uniprot/C6KT53 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/36329:PF3D7_0310400 ^@ http://purl.uniprot.org/uniprot/O77361 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1437800 ^@ http://purl.uniprot.org/uniprot/Q7KQM2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Blood stage antigen transported to the erythrocyte surface.|||Cell membrane|||Endoplasmic reticulum|||Host membrane|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||Part of the multisubunit TRAPP (transport protein particle) complex.|||cis-Golgi network http://togogenome.org/gene/36329:PF3D7_1134000 ^@ http://purl.uniprot.org/uniprot/Q8II24 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/36329:PF3D7_1312600 ^@ http://purl.uniprot.org/uniprot/Q8IEJ6 ^@ Function|||Similarity ^@ Belongs to the BCKDHA family.|||The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains multiple copies of three enzymatic components: branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). http://togogenome.org/gene/36329:PF3D7_1006900 ^@ http://purl.uniprot.org/uniprot/Q8IJX2 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/36329:PF3D7_0102900 ^@ http://purl.uniprot.org/uniprot/Q8I2B1 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily. http://togogenome.org/gene/36329:PF3D7_0816000 ^@ http://purl.uniprot.org/uniprot/Q8IAZ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0404400 ^@ http://purl.uniprot.org/uniprot/Q8I1Y5 ^@ Disruption Phenotype|||Function|||Subcellular Location Annotation ^@ Attenuated parasites that cannot commit to infection, even when they encounter with hepatocytes, resulting in continuous traversal of hepatocytes.|||Cell membrane|||Cell surface|||Involved in sporozoite infection of hepatocytes and replication therein. http://togogenome.org/gene/36329:PF3D7_0815200 ^@ http://purl.uniprot.org/uniprot/Q8IAY9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1314500 ^@ http://purl.uniprot.org/uniprot/Q8I6T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1451700 ^@ http://purl.uniprot.org/uniprot/Q8IKV9 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/36329:PF3D7_1324900 ^@ http://purl.uniprot.org/uniprot/Q76NM3 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/36329:PF3D7_0501800 ^@ http://purl.uniprot.org/uniprot/Q8I482 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat HIR1 family.|||Nucleus|||Required for replication-independent chromatin assembly and for the periodic repression of histone gene transcription during the cell cycle. http://togogenome.org/gene/36329:PF3D7_1027400 ^@ http://purl.uniprot.org/uniprot/Q8IJC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0812400 ^@ http://purl.uniprot.org/uniprot/Q8IAW0 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/36329:PF3D7_0304600 ^@ http://purl.uniprot.org/uniprot/Q7K740 ^@ Biotechnology|||Domain|||Function|||PTM|||Polymorphism|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plasmodium circumsporozoite protein family.|||CSP immunodominant B cell epitopes are primarily located in the central repeats (PubMed:29554084). Antibodies against CSP and particularly against the central repeats can neutralize infection at the pre-liver stage and thus makes CSP an attractive candidate for the development of vaccines (PubMed:29554084, PubMed:32150583).|||Cell membrane|||Cytoplasm|||During host cell invasion, proteolytically cleaved at the cell membrane in the region I by a papain-like cysteine protease of parasite origin (By similarity). Cleavage is triggered by the sporozoite contact with highly sulfated heparan sulfate proteoglycans (HSPGs) present on the host hepatocyte cell surface (By similarity). Cleavage exposes the TSP type-1 (TSR) domain and is required for productive invasion of host hepatocytes but not for adhesion to the host cell membrane (By similarity). Cleavage is dispensable for sporozoite development in the oocyst, motility and for traversal of host and vector cells (By similarity).|||Essential sporozoite protein (PubMed:29554084, PubMed:32150583). In the mosquito vector, required for sporozoite development in the oocyst, migration through the vector hemolymph and entry into the vector salivary glands (By similarity). In the vertebrate host, required for sporozoite migration through the host dermis and infection of host hepatocytes (PubMed:29554084, PubMed:32150583). Binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (By similarity).|||In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.|||O-glycosylated; maybe by POFUT2.|||The GPI-anchor is essential for cell membrane localization and for sporozoite formation inside the oocyst.|||The N-terminus is involved in the initial binding to heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes (PubMed:27560376). The N-terminus masks the TSP type-1 (TSR) domain which maintains the sporozoites in a migratory state, enabling them to complete their journey to the salivary gland in the mosquito vector and then to the host liver. The unmasking of the TSP type-1 (TSR) domain when the sporozoite interacts with the host hepatocyte also protects sporozoites from host antibodies (By similarity).|||The TSP type-1 (TSR) domain is required for sporozoite development and invasion. CSP has two conformational states, an adhesive conformation in which the TSP type-1 (TSR) domain is exposed and a nonadhesive conformation in which the TSR is masked by the N-terminus. TSR-exposed conformation occurs during sporozoite development in the oocyst in the mosquito vector and during host hepatocyte invasion. TSR-masked conformation occurs during sporozoite migration through the hemolymph to salivary glands in the mosquito vector and in the host dermis.|||The sequence of the repeats varies across Plasmodium species and strains. http://togogenome.org/gene/36329:PF3D7_1415800 ^@ http://purl.uniprot.org/uniprot/Q8ILT8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/36329:PF3D7_1106000 ^@ http://purl.uniprot.org/uniprot/Q8IIU3 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/36329:PF3D7_1346800 ^@ http://purl.uniprot.org/uniprot/Q8IDN0 ^@ Developmental Stage|||Disruption Phenotype|||Function|||Miscellaneous|||Subcellular Location Annotation ^@ Cell membrane|||Cell surface|||Exhibits a high rate of non-synonymous polymorphism is different strains, suggesting that it adapts to different Anopheles vector species.|||Expressed only in female gametocytes following emergence from red blood cells.|||Mediates evasion of the mosquito innate immune response by suppressing midgut nitration responses that are critical to activate the mosquito complement system. It is unclear whether the protein has a role in passive evasion by making the parasite invisible to the mosquito immune system, acts as a decoy to prevent recognition of another surface protein or anchors the decoy protein. Not required for female fertility.|||Reduced parasite survival in the mosquito. Parasites produce normal numbers of oocysts when included in the blood meal of the mosquito vector. http://togogenome.org/gene/36329:PF3D7_0730200 ^@ http://purl.uniprot.org/uniprot/Q8IBF8 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/36329:PF3D7_0925200 ^@ http://purl.uniprot.org/uniprot/Q8I2Q6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RRP8 family.|||Probable methyltransferase required to silence rDNA.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1018500 ^@ http://purl.uniprot.org/uniprot/C6S3D1 ^@ Similarity ^@ Belongs to the PHF5 family. http://togogenome.org/gene/36329:PF3D7_0524900 ^@ http://purl.uniprot.org/uniprot/Q8I3L6 ^@ Similarity ^@ Belongs to the TYW1 family. http://togogenome.org/gene/36329:PF3D7_1202100.1 ^@ http://purl.uniprot.org/uniprot/Q8I624 ^@ Similarity ^@ Belongs to the SOS response-associated peptidase family. http://togogenome.org/gene/36329:PF3D7_1015600 ^@ http://purl.uniprot.org/uniprot/Q8IJN9 ^@ Similarity ^@ Belongs to the chaperonin (HSP60) family. http://togogenome.org/gene/36329:PF3D7_1205000 ^@ http://purl.uniprot.org/uniprot/Q8I5Z5 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1325600 ^@ http://purl.uniprot.org/uniprot/Q8IE63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIS1 family.|||Mitochondrion outer membrane http://togogenome.org/gene/36329:PF3D7_0414300 ^@ http://purl.uniprot.org/uniprot/C0H4A3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1239200 ^@ http://purl.uniprot.org/uniprot/Q8I531 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1124800 ^@ http://purl.uniprot.org/uniprot/Q8IIB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRS1 family.|||Involved in ribosomal large subunit assembly.|||Nucleus http://togogenome.org/gene/36329:PF3D7_1012400 ^@ http://purl.uniprot.org/uniprot/Q8IJS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1409900 ^@ http://purl.uniprot.org/uniprot/Q8ILZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0927700 ^@ http://purl.uniprot.org/uniprot/Q8I2N2 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_1467100 ^@ http://purl.uniprot.org/uniprot/Q8IKG6 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/36329:PF3D7_1108000 ^@ http://purl.uniprot.org/uniprot/Q8IIS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0514800 ^@ http://purl.uniprot.org/uniprot/Q8I3W0 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/36329:PF3D7_1121000 ^@ http://purl.uniprot.org/uniprot/Q8IIF7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_0516900 ^@ http://purl.uniprot.org/uniprot/Q8I3T9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/36329:PF3D7_1401100 ^@ http://purl.uniprot.org/uniprot/Q8IM77 ^@ Biotechnology|||Subcellular Location Annotation ^@ Membrane|||Possible candidate for an effective malaria vaccine as determined by epitope response in sera. http://togogenome.org/gene/36329:PF3D7_1211100 ^@ http://purl.uniprot.org/uniprot/Q8I5T9 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/36329:PF3D7_0109800 ^@ http://purl.uniprot.org/uniprot/Q8I246 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily. http://togogenome.org/gene/36329:PF3D7_1304900 ^@ http://purl.uniprot.org/uniprot/Q8IER7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Component of the RNA polymerase II (Pol II) complex consisting of 12 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft (By similarity).|||Nucleus http://togogenome.org/gene/36329:PF3D7_0803100 ^@ http://purl.uniprot.org/uniprot/Q8IAN1 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/36329:PF3D7_1029400 ^@ http://purl.uniprot.org/uniprot/Q8IJB1 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/36329:PF3D7_0816300 ^@ http://purl.uniprot.org/uniprot/C0H4U8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAP2/GCS1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1248900 ^@ http://purl.uniprot.org/uniprot/Q8I4U5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0502200 ^@ http://purl.uniprot.org/uniprot/Q8I478 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0726300 ^@ http://purl.uniprot.org/uniprot/Q8IBJ3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/36329:PF3D7_0305600 ^@ http://purl.uniprot.org/uniprot/O97240 ^@ Activity Regulation|||Cofactor|||Developmental Stage|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Apurinic/apyrimidinic (AP) endonuclease activity is maximal at low Mg(2+) (0.5-2 mM) with no activity seen at high concentrations (more than 10 mM) (PubMed:33743509). 3'-5' exonuclease activity is maximal in the range of 0.5-2 mM Mg(2+) with activity seen up to 10 mM Mg(2+) (PubMed:33743509).|||Belongs to the DNA repair enzymes AP/ExoA family.|||Expressed during the asexual blood stage, including trophozoites (at protein level).|||May be proteolytically cleaved into a 64 kDa form.|||Mitochondrion|||Multifunctional protein that plays a central role in mitochondrial DNA base excision repair (BER) pathway induced by oxidative stress. Has apurinic/apyrimidinic (AP) endonuclease activity towards double-stranded DNA (dsDNA) (PubMed:33743509). Has nucleotide incision repair (NIR) activity; acts on dsDNA with oxidized bases thymine glycol and 5,6-dihydro-2'-deoxyuridine (PubMed:33743509). Has 3'-5' exonuclease; can use dsDNA templates with 3'-OH termini including blunt-end, gapped and mismatched 3'-recessed (PubMed:33743509). Has 3'-phosphatase activity; cleaves 3'-phosphate from blunt, recessed and gapped dsDNA templates, followed by 3'-5' exonuclease activity (PubMed:33743509). Has RNase H-like activity; cleaves RNA on 3'-recessed RNA-DNA duplex (PubMed:33743509). Plays a role in merosome infection of host erythrocytes (By similarity).|||Probably binds two magnesium or manganese ions per subunit. http://togogenome.org/gene/36329:PF3D7_1325100 ^@ http://purl.uniprot.org/uniprot/Q8IE67 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/36329:PF3D7_1434300 ^@ http://purl.uniprot.org/uniprot/Q8ILC1 ^@ Caution|||Developmental Stage|||Domain|||Function|||Induction|||Subcellular Location Annotation|||Subunit ^@ Acts as a co-chaperone and mediates the association of the chaperones HSP70 and HSP90 probably facilitating substrate transfer from HSP70 to HSP90 (PubMed:22005844, PubMed:26267894). Stimulates HSP70 ATPase activity and, in contrast, inhibits HSP90 ATPase activity (PubMed:31525467).|||By heat stress (at protein level).|||Cytoplasm|||Expressed during the parasite blood stage, in trophozoites (at protein level).|||Monomer (PubMed:32343703). Homodimer (PubMed:26267894, PubMed:31525467). Forms a complex composed of HOP and chaperones HSP70 and HSP90; the interaction is stronger in the absence of ATP (PubMed:22005844). Interacts (via TPR 1, 2, 3, 7, 8 and 9 repeats) with HSP70 (via C-terminus); the interaction is direct and is stronger in the absence of ATP (PubMed:26267894). Interacts (via TPR 4, 5 and 6 repeats) with HSP90 (via C-terminus); the interaction is direct (PubMed:26267894).|||Showed to form heterodimers (PubMed:26267894, PubMed:31525467). However in a later study, showed to exist predominantly as a monomer (PubMed:32343703).|||The TPR repeats form 3 domains; the TPR 1 domain is composed of TPR 1, 2 and 3 repeats, the TPR2A domain of TPR 4, 5 and 6 repeats and TPR2B domain of TPR 7, 8 and 9 repeats. http://togogenome.org/gene/36329:PF3D7_0906910 ^@ http://purl.uniprot.org/uniprot/Q8I381 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCB family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1424100 ^@ http://purl.uniprot.org/uniprot/Q8ILL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_1116300 ^@ http://purl.uniprot.org/uniprot/Q8IIK3 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_1308300 ^@ http://purl.uniprot.org/uniprot/Q8IEN2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family. http://togogenome.org/gene/36329:PF3D7_1323200 ^@ http://purl.uniprot.org/uniprot/Q8IE84 ^@ Similarity ^@ Belongs to the V-ATPase G subunit family. http://togogenome.org/gene/36329:PF3D7_1456600 ^@ http://purl.uniprot.org/uniprot/Q8IKR3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/36329:PF3D7_0210100.1 ^@ http://purl.uniprot.org/uniprot/O96184 ^@ Developmental Stage|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family.|||Component of the large ribosomal subunit (PubMed:24913268, PubMed:26432834, PubMed:28288098). Mature ribosomes consist of a small (40S) and a large (60S) subunit (PubMed:24913268, PubMed:26432834). The 40S subunit contains about 32 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 42 different proteins and 3 molecules of RNA (28S, 5.8S and 5S) (PubMed:24913268, PubMed:26432834).|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell (PubMed:28288098). The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules (Probable). The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain (Probable). The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel (Probable).|||Cytoplasm|||Expressed during the asexual blood stage (at protein level). http://togogenome.org/gene/36329:PF3D7_1438500 ^@ http://purl.uniprot.org/uniprot/Q8IL83 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1235500 ^@ http://purl.uniprot.org/uniprot/Q8I567 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/36329:PF3D7_1245600 ^@ http://purl.uniprot.org/uniprot/Q8I4X5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/36329:PF3D7_1227100 ^@ http://purl.uniprot.org/uniprot/Q8I5E7 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/36329:PF3D7_1435300 ^@ http://purl.uniprot.org/uniprot/Q8ILB1 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/36329:PF3D7_0415500 ^@ http://purl.uniprot.org/uniprot/Q8I1T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM NCBP2 family.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0826400 ^@ http://purl.uniprot.org/uniprot/Q8IB97 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/36329:PF3D7_1205600 ^@ http://purl.uniprot.org/uniprot/Q8I5Y9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1339500 ^@ http://purl.uniprot.org/uniprot/A0A5K1K9F4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL49 family.|||Mitochondrion http://togogenome.org/gene/36329:PF3D7_1028300 ^@ http://purl.uniprot.org/uniprot/Q8IJC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EBP2 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0610900 ^@ http://purl.uniprot.org/uniprot/C6KSV4 ^@ Similarity ^@ Belongs to the SPT5 family. http://togogenome.org/gene/36329:PF3D7_1031300 ^@ http://purl.uniprot.org/uniprot/Q8IJ92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0525900 ^@ http://purl.uniprot.org/uniprot/C0H4G2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/36329:PF3D7_1355100 ^@ http://purl.uniprot.org/uniprot/Q8IDF0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0716600 ^@ http://purl.uniprot.org/uniprot/Q8IBT4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_0728900 ^@ http://purl.uniprot.org/uniprot/C0H4P9 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/36329:PF3D7_0517000 ^@ http://purl.uniprot.org/uniprot/Q8I3T8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/36329:PF3D7_1118500 ^@ http://purl.uniprot.org/uniprot/Q8III3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0820500 ^@ http://purl.uniprot.org/uniprot/Q8IB40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIF1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_1202400 ^@ http://purl.uniprot.org/uniprot/Q8I621 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/36329:PF3D7_0705000 ^@ http://purl.uniprot.org/uniprot/Q8IC20 ^@ Similarity ^@ In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family. http://togogenome.org/gene/36329:PF3D7_1217100.1 ^@ http://purl.uniprot.org/uniprot/Q8I5N7 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/36329:PF3D7_1340600 ^@ http://purl.uniprot.org/uniprot/A0A5K1K8J0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1406000 ^@ http://purl.uniprot.org/uniprot/Q8IM34 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/36329:PF3D7_1438100 ^@ http://purl.uniprot.org/uniprot/Q8IL86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/36329:PF3D7_0729300 ^@ http://purl.uniprot.org/uniprot/Q8IBG6 ^@ Similarity ^@ Belongs to the NMD3 family. http://togogenome.org/gene/36329:PF3D7_0409700 ^@ http://purl.uniprot.org/uniprot/Q8I1W0 ^@ Similarity ^@ Belongs to the prokaryotic/mitochondrial release factor family. http://togogenome.org/gene/36329:PF3D7_0207900 ^@ http://purl.uniprot.org/uniprot/O96166 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/36329:PF3D7_1122800 ^@ http://purl.uniprot.org/uniprot/Q8IID5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. CDPK subfamily. http://togogenome.org/gene/36329:PF3D7_1317200 ^@ http://purl.uniprot.org/uniprot/Q8IEE4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1321400 ^@ http://purl.uniprot.org/uniprot/Q8IEA0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/36329:PF3D7_1455500 ^@ http://purl.uniprot.org/uniprot/Q8IKS3 ^@ Subcellular Location Annotation ^@ coated pit http://togogenome.org/gene/36329:PF3D7_0607500 ^@ http://purl.uniprot.org/uniprot/C6KSS3 ^@ Similarity ^@ Belongs to the UbiA prenyltransferase family. http://togogenome.org/gene/36329:PF3D7_1211700 ^@ http://purl.uniprot.org/uniprot/Q8I5T4 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/36329:PF3D7_1206200 ^@ http://purl.uniprot.org/uniprot/Q8I5Y3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit C family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex.|||Cytoplasm http://togogenome.org/gene/36329:PF3D7_0108400.1 ^@ http://purl.uniprot.org/uniprot/B9ZSI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/36329:PF3D7_1005100 ^@ http://purl.uniprot.org/uniprot/Q8IJY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1110600 ^@ http://purl.uniprot.org/uniprot/Q8IIQ5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL11 family. http://togogenome.org/gene/36329:PF3D7_1108300 ^@ http://purl.uniprot.org/uniprot/C6S3E6 ^@ Similarity ^@ Belongs to the pterin-4-alpha-carbinolamine dehydratase family. http://togogenome.org/gene/36329:PF3D7_1011300 ^@ http://purl.uniprot.org/uniprot/Q8IJT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARV1 family.|||Endoplasmic reticulum membrane|||Mediator of sterol homeostasis involved in sterol uptake, trafficking and distribution into membranes.|||Membrane|||Regulates also the sphingolipid metabolism. http://togogenome.org/gene/36329:PF3D7_0819900 ^@ http://purl.uniprot.org/uniprot/C0H4W2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0917700 ^@ http://purl.uniprot.org/uniprot/Q8I2X6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/36329:PF3D7_1027600 ^@ http://purl.uniprot.org/uniprot/C6S3D8 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/36329:PF3D7_0828500 ^@ http://purl.uniprot.org/uniprot/Q8IBB6 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/36329:PF3D7_1466700 ^@ http://purl.uniprot.org/uniprot/Q8IKH0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NIP7 family.|||Interacts with pre-ribosome complex.|||Required for proper 27S pre-rRNA processing and 60S ribosome subunit assembly.|||nucleolus http://togogenome.org/gene/36329:PF3D7_1022500 ^@ http://purl.uniprot.org/uniprot/Q8I6U7 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/36329:PF3D7_0417300 ^@ http://purl.uniprot.org/uniprot/Q8I1R5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1238100 ^@ http://purl.uniprot.org/uniprot/Q8I542 ^@ Function ^@ May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1). http://togogenome.org/gene/36329:PF3D7_0501900 ^@ http://purl.uniprot.org/uniprot/Q8I481 ^@ Similarity ^@ Belongs to the TRAPPC13 family. http://togogenome.org/gene/36329:PF3D7_1355700 ^@ http://purl.uniprot.org/uniprot/Q8IDE5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_0524000 ^@ http://purl.uniprot.org/uniprot/Q8I3M5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0708100 ^@ http://purl.uniprot.org/uniprot/Q8IC08 ^@ Similarity ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family. http://togogenome.org/gene/36329:PF3D7_1118200 ^@ http://purl.uniprot.org/uniprot/Q8III6 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/36329:PF3D7_1103700 ^@ http://purl.uniprot.org/uniprot/Q8IIW5 ^@ Similarity|||Subunit ^@ Belongs to the casein kinase 2 subunit beta family.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/36329:PF3D7_0628600 ^@ http://purl.uniprot.org/uniprot/C6KTC1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/36329:PF3D7_1409300 ^@ http://purl.uniprot.org/uniprot/Q8IM03 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/36329:PF3D7_1306400 ^@ http://purl.uniprot.org/uniprot/Q8IEQ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/36329:PF3D7_1028400 ^@ http://purl.uniprot.org/uniprot/Q8IJC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/36329:PF3D7_0608800 ^@ http://purl.uniprot.org/uniprot/Q6LFH8 ^@ Activity Regulation|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Cytoplasm|||Homodimer.|||The disulfide bond between Cys-154 and Cys-163 is reduced by TRX1 which increases OAT catalytic activity.|||The enzyme has a very narrow substrate specificity and can only catalyze the transamination of alpha-ketoglutarate with ornithine or N-acetylornithine and, to a lesser extent, of glutamate-5-semialdehyde with glutamate and alanine.|||Unlike for mammalian OATs, activity is increased by TRX1-mediated reduction of the disulfide bond between Cys-154 and Cys-163 (PubMed:20673832). Binding to TRX1 may also induce conformational changes that facilitate substrate binding (PubMed:20673832). http://togogenome.org/gene/36329:PF3D7_0314400 ^@ http://purl.uniprot.org/uniprot/O97259 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/36329:PF3D7_1304500 ^@ http://purl.uniprot.org/uniprot/Q8IES0 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/36329:PF3D7_0803800 ^@ http://purl.uniprot.org/uniprot/Q7K6A9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1B family.|||Cytoplasm|||Non-catalytic component of the proteasome.|||Nucleus http://togogenome.org/gene/36329:PF3D7_0522600 ^@ http://purl.uniprot.org/uniprot/Q8I3N7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/36329:PF3D7_1225700 ^@ http://purl.uniprot.org/uniprot/Q8I5G0 ^@ Similarity ^@ Belongs to the VAC14 family. http://togogenome.org/gene/36329:PF3D7_0411800 ^@ http://purl.uniprot.org/uniprot/Q9U0H2 ^@ Similarity ^@ Belongs to the GOLGA6 family. http://togogenome.org/gene/36329:PF3D7_1131100 ^@ http://purl.uniprot.org/uniprot/Q8II53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/36329:PF3D7_0804600 ^@ http://purl.uniprot.org/uniprot/C0H4R3 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/36329:PF3D7_1414000 ^@ http://purl.uniprot.org/uniprot/Q8ILV5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/36329:PF3D7_0818900 ^@ http://purl.uniprot.org/uniprot/Q8IB24 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/36329:PF3D7_1020100 ^@ http://purl.uniprot.org/uniprot/C6S3D2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function. Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules.|||Belongs to the GAMAD family.|||cytoskeleton http://togogenome.org/gene/36329:PF3D7_0602400 ^@ http://purl.uniprot.org/uniprot/C6KSM4 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.