http://togogenome.org/gene/415426:HBUT_RS08175 ^@ http://purl.uniprot.org/uniprot/A2BN21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS00575 ^@ http://purl.uniprot.org/uniprot/A2BJ25 ^@ Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS06770 ^@ http://purl.uniprot.org/uniprot/A2BMB2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/415426:HBUT_RS07855 ^@ http://purl.uniprot.org/uniprot/A2BMW0 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/415426:HBUT_RS00500 ^@ http://purl.uniprot.org/uniprot/A2BJ10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08585 ^@ http://purl.uniprot.org/uniprot/A2BN95 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS08345 ^@ http://purl.uniprot.org/uniprot/A2BN53 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS08675 ^@ http://purl.uniprot.org/uniprot/A2BNB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. This subunit is less well bound than the others.|||Part of the RNA polymerase complex. Forms a stalk with Rpo7 that extends from the main structure. http://togogenome.org/gene/415426:HBUT_RS04655 ^@ http://purl.uniprot.org/uniprot/A2BL73 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase archaeal type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/415426:HBUT_RS07420 ^@ http://purl.uniprot.org/uniprot/A2BMN3 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/415426:HBUT_RS02395 ^@ http://purl.uniprot.org/uniprot/A2BK15 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/415426:HBUT_RS00550 ^@ http://purl.uniprot.org/uniprot/A2BJ20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/415426:HBUT_RS08665 ^@ http://purl.uniprot.org/uniprot/A2BNB0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/415426:HBUT_RS04345 ^@ http://purl.uniprot.org/uniprot/A2BL19 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/415426:HBUT_RS03970 ^@ http://purl.uniprot.org/uniprot/A2BKU8 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/415426:HBUT_RS04370 ^@ http://purl.uniprot.org/uniprot/A2BL23 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/415426:HBUT_RS00855 ^@ http://purl.uniprot.org/uniprot/A2BJ77 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M32 family.|||Binds 1 zinc ion per subunit.|||Broad specificity carboxypetidase that releases amino acids sequentially from the C-terminus, including neutral, aromatic, polar and basic residues. http://togogenome.org/gene/415426:HBUT_RS00835 ^@ http://purl.uniprot.org/uniprot/A2BJ73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08410 ^@ http://purl.uniprot.org/uniprot/A2BN65 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS05610 ^@ http://purl.uniprot.org/uniprot/A2BLQ6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the decarboxylation of S-adenosylmethionine to S-adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine.|||Heterotetramer of two alpha and two beta chains arranged as a dimer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain. http://togogenome.org/gene/415426:HBUT_RS00115 ^@ http://purl.uniprot.org/uniprot/A2BIU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/415426:HBUT_RS01595 ^@ http://purl.uniprot.org/uniprot/A2BJL3 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/415426:HBUT_RS02565 ^@ http://purl.uniprot.org/uniprot/A2BK43 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/415426:HBUT_RS04945 ^@ http://purl.uniprot.org/uniprot/A2BLD1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/415426:HBUT_RS08645 ^@ http://purl.uniprot.org/uniprot/A2BNA6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/415426:HBUT_RS02620 ^@ http://purl.uniprot.org/uniprot/A2BK54 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Because the Archaea possessing a type III RuBisCO are all anaerobic, it is most likely that only the carboxylase activity of RuBisCO, and not the competitive oxygenase activity (by which RuBP reacts with O(2) to form one molecule of 3-phosphoglycerate and one molecule of 2-phosphoglycolate), is biologically relevant in these strains.|||Belongs to the RuBisCO large chain family. Type III subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the addition of molecular CO(2) and H(2)O to ribulose 1,5-bisphosphate (RuBP), generating two molecules of 3-phosphoglycerate (3-PGA). Functions in an archaeal AMP degradation pathway, together with AMP phosphorylase and R15P isomerase.|||Homodimer or homodecamer. In contrast to form I RuBisCO, the form III RuBisCO is composed solely of large subunits. http://togogenome.org/gene/415426:HBUT_RS06050 ^@ http://purl.uniprot.org/uniprot/A2BLY6 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/415426:HBUT_RS00205 ^@ http://purl.uniprot.org/uniprot/A2BIV7 ^@ Similarity ^@ Belongs to the deoxyhypusine synthase family. http://togogenome.org/gene/415426:HBUT_RS00630 ^@ http://purl.uniprot.org/uniprot/A2BJ36 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/415426:HBUT_RS01990 ^@ http://purl.uniprot.org/uniprot/A2BJU0 ^@ Function|||Similarity ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family. Type 2 subfamily.|||Catalyzes the conversion of AMP and phosphate to adenine and ribose 1,5-bisphosphate (R15P). Exhibits phosphorylase activity toward CMP and UMP in addition to AMP. Functions in an archaeal AMP degradation pathway, together with R15P isomerase and RubisCO. http://togogenome.org/gene/415426:HBUT_RS08165 ^@ http://purl.uniprot.org/uniprot/A2BN19 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/415426:HBUT_RS06210 ^@ http://purl.uniprot.org/uniprot/A2BM14 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/415426:HBUT_RS04990 ^@ http://purl.uniprot.org/uniprot/A2BLE0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/415426:HBUT_RS04030 ^@ http://purl.uniprot.org/uniprot/A2BKV9 ^@ Similarity ^@ Belongs to the UPF0252 family. http://togogenome.org/gene/415426:HBUT_RS04980 ^@ http://purl.uniprot.org/uniprot/A2BLD8 ^@ Function|||Similarity ^@ Belongs to the archaeal 6-HMPDK family.|||Catalyzes the transfer of diphosphate from ATP to 6-hydroxymethyl-7,8-dihydropterin (6-HMD), leading to 6-hydroxymethyl-7,8-dihydropterin diphosphate (6-HMDP). http://togogenome.org/gene/415426:HBUT_RS01190 ^@ http://purl.uniprot.org/uniprot/A2BJD9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/415426:HBUT_RS00570 ^@ http://purl.uniprot.org/uniprot/A2BJ24 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/415426:HBUT_RS06935 ^@ http://purl.uniprot.org/uniprot/A2BME5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/415426:HBUT_RS04025 ^@ http://purl.uniprot.org/uniprot/A2BKV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTH2 family.|||Cytoplasm|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/415426:HBUT_RS01755 ^@ http://purl.uniprot.org/uniprot/A2BJP4 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/415426:HBUT_RS00975 ^@ http://purl.uniprot.org/uniprot/A2BJA1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS02840 ^@ http://purl.uniprot.org/uniprot/A2BK96 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL24 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L14. http://togogenome.org/gene/415426:HBUT_RS07510 ^@ http://purl.uniprot.org/uniprot/A2BMQ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06275 ^@ http://purl.uniprot.org/uniprot/A2BM26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm|||Reversibly catalyzes the transfer of the carbamoyl group from carbamoyl phosphate (CP) to the N(epsilon) atom of ornithine (ORN) to produce L-citrulline. http://togogenome.org/gene/415426:HBUT_RS03380 ^@ http://purl.uniprot.org/uniprot/A2BKJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/415426:HBUT_RS04750 ^@ http://purl.uniprot.org/uniprot/A2BL92 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/415426:HBUT_RS06545 ^@ http://purl.uniprot.org/uniprot/A2BM73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS08280 ^@ http://purl.uniprot.org/uniprot/A2BN42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS06320 ^@ http://purl.uniprot.org/uniprot/A2BM34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS03180 ^@ http://purl.uniprot.org/uniprot/A2BKG0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/415426:HBUT_RS02000 ^@ http://purl.uniprot.org/uniprot/A2BJU2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Cytoplasm|||Homodimer or homotetramer.|||Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to 1,3-diaminopropane to yield sym-norspermidine (bis(3-aminopropyl)amine). It can also synthesize thermospermine from spermidine with a very low activity. http://togogenome.org/gene/415426:HBUT_RS02505 ^@ http://purl.uniprot.org/uniprot/A2BK32 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/415426:HBUT_RS02835 ^@ http://purl.uniprot.org/uniprot/A2BK95 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS28 family. http://togogenome.org/gene/415426:HBUT_RS02850 ^@ http://purl.uniprot.org/uniprot/A2BK98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||Cytoplasm|||Major role in the synthesis of nucleoside triphosphates other than ATP. The ATP gamma phosphate is transferred to the NDP beta phosphate via a ping-pong mechanism, using a phosphorylated active-site intermediate. http://togogenome.org/gene/415426:HBUT_RS06825 ^@ http://purl.uniprot.org/uniprot/A2BMC3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/415426:HBUT_RS04355 ^@ http://purl.uniprot.org/uniprot/A2BL20 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/415426:HBUT_RS05230 ^@ http://purl.uniprot.org/uniprot/A2BLI7 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/415426:HBUT_RS05275 ^@ http://purl.uniprot.org/uniprot/A2BLJ5 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/415426:HBUT_RS05385 ^@ http://purl.uniprot.org/uniprot/A2BLL4 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/415426:HBUT_RS02985 ^@ http://purl.uniprot.org/uniprot/A2BKC4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/415426:HBUT_RS06860 ^@ http://purl.uniprot.org/uniprot/A2BMD0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS08130 ^@ http://purl.uniprot.org/uniprot/A2BN13 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/415426:HBUT_RS05825 ^@ http://purl.uniprot.org/uniprot/A2BLU7 ^@ Function ^@ Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/415426:HBUT_RS01840 ^@ http://purl.uniprot.org/uniprot/A2BJR2 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/415426:HBUT_RS02305 ^@ http://purl.uniprot.org/uniprot/A2BJZ8 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/415426:HBUT_RS08370 ^@ http://purl.uniprot.org/uniprot/A2BN58 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL20 family.|||Part of the 50S ribosomal subunit. Binds 23S rRNA. http://togogenome.org/gene/415426:HBUT_RS06690 ^@ http://purl.uniprot.org/uniprot/A2BM98 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS03965 ^@ http://purl.uniprot.org/uniprot/A2BKU7 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/415426:HBUT_RS05205 ^@ http://purl.uniprot.org/uniprot/A2BLI2 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/415426:HBUT_RS02775 ^@ http://purl.uniprot.org/uniprot/A2BK83 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo10/eukaryotic RPB10 RNA polymerase subunit family.|||Binds 1 zinc ion.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS05060 ^@ http://purl.uniprot.org/uniprot/A2BLF3 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of threonine to tRNA(Thr) in a two-step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).|||Cytoplasm|||Homodimer.|||The N-terminal domain is an archaea-specific tRNA-editing domain that hydrolyzes incorrectly charged L-seryl-tRNA(Thr). Catalysis of tRNA editing is performed by the charged tRNA itself. http://togogenome.org/gene/415426:HBUT_RS07485 ^@ http://purl.uniprot.org/uniprot/A2BMP5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS04880 ^@ http://purl.uniprot.org/uniprot/A2BLB7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/415426:HBUT_RS06580 ^@ http://purl.uniprot.org/uniprot/A2BM80 ^@ Similarity ^@ Belongs to the ZPR1 family. http://togogenome.org/gene/415426:HBUT_RS00095 ^@ http://purl.uniprot.org/uniprot/A2BIU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/415426:HBUT_RS06725 ^@ http://purl.uniprot.org/uniprot/A2BMA5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/415426:HBUT_RS01100 ^@ http://purl.uniprot.org/uniprot/A2BJC3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS07785 ^@ http://purl.uniprot.org/uniprot/A2BMU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS05140 ^@ http://purl.uniprot.org/uniprot/A2BLG9 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/415426:HBUT_RS04670 ^@ http://purl.uniprot.org/uniprot/A2BL76 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/415426:HBUT_RS02300 ^@ http://purl.uniprot.org/uniprot/A2BJZ7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/415426:HBUT_RS05320 ^@ http://purl.uniprot.org/uniprot/A2BLK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS05855 ^@ http://purl.uniprot.org/uniprot/A2BLV2 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/415426:HBUT_RS04530 ^@ http://purl.uniprot.org/uniprot/A2BL51 ^@ Similarity|||Subunit ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family.|||Homohexamer. http://togogenome.org/gene/415426:HBUT_RS04190 ^@ http://purl.uniprot.org/uniprot/A2BKZ1 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/415426:HBUT_RS02330 ^@ http://purl.uniprot.org/uniprot/A2BK03 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/415426:HBUT_RS08330 ^@ http://purl.uniprot.org/uniprot/A2BN50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/415426:HBUT_RS03865 ^@ http://purl.uniprot.org/uniprot/A2BKS9 ^@ Similarity ^@ Belongs to the tRNA methyltransferase O family. http://togogenome.org/gene/415426:HBUT_RS03765 ^@ http://purl.uniprot.org/uniprot/A2BKR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS06575 ^@ http://purl.uniprot.org/uniprot/A2BM79 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/415426:HBUT_RS00655 ^@ http://purl.uniprot.org/uniprot/A2BJ42 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the diphthine synthase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes the trimethylation of the amino group of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine. The three successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/415426:HBUT_RS03300 ^@ http://purl.uniprot.org/uniprot/A2BKI1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/415426:HBUT_RS04790 ^@ http://purl.uniprot.org/uniprot/A2BL99 ^@ Function ^@ Part of a potassium transport system. http://togogenome.org/gene/415426:HBUT_RS03485 ^@ http://purl.uniprot.org/uniprot/A2BKL6 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the UPF0165 family. http://togogenome.org/gene/415426:HBUT_RS08050 ^@ http://purl.uniprot.org/uniprot/A2BMZ8 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/415426:HBUT_RS04160 ^@ http://purl.uniprot.org/uniprot/A2BKY5 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/415426:HBUT_RS05415 ^@ http://purl.uniprot.org/uniprot/A2BLM0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/415426:HBUT_RS02960 ^@ http://purl.uniprot.org/uniprot/A2BKC0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp41 subfamily.|||Catalytic component of the exosome, which is a complex involved in RNA degradation. Has 3'->5' exoribonuclease activity. Can also synthesize heteromeric RNA-tails.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS06980 ^@ http://purl.uniprot.org/uniprot/A2BMF3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/415426:HBUT_RS02870 ^@ http://purl.uniprot.org/uniprot/A2BKA2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family. http://togogenome.org/gene/415426:HBUT_RS02765 ^@ http://purl.uniprot.org/uniprot/A2BK81 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/415426:HBUT_RS08640 ^@ http://purl.uniprot.org/uniprot/A2BNA5 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/415426:HBUT_RS03815 ^@ http://purl.uniprot.org/uniprot/A2BKS2 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/415426:HBUT_RS05755 ^@ http://purl.uniprot.org/uniprot/A2BLT6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/415426:HBUT_RS06845 ^@ http://purl.uniprot.org/uniprot/A2BMC7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/415426:HBUT_RS00670 ^@ http://purl.uniprot.org/uniprot/A2BJ45 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/415426:HBUT_RS02445 ^@ http://purl.uniprot.org/uniprot/A2BK22 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the archaeosine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Exchanges the guanine residue with 7-cyano-7-deazaguanine (preQ0) at position 15 in the dihydrouridine loop (D-loop) of archaeal tRNAs.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS06880 ^@ http://purl.uniprot.org/uniprot/A2BMD4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS07805 ^@ http://purl.uniprot.org/uniprot/A2BMV1 ^@ Similarity ^@ Belongs to the UPF0215 family. http://togogenome.org/gene/415426:HBUT_RS01120 ^@ http://purl.uniprot.org/uniprot/A2BJC7 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/415426:HBUT_RS03870 ^@ http://purl.uniprot.org/uniprot/A2BKT0 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/415426:HBUT_RS03905 ^@ http://purl.uniprot.org/uniprot/A2BKT7 ^@ Similarity ^@ Belongs to the archaeal ATPase family. http://togogenome.org/gene/415426:HBUT_RS06855 ^@ http://purl.uniprot.org/uniprot/A2BMC9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/415426:HBUT_RS01180 ^@ http://purl.uniprot.org/uniprot/A2BJD7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS02750 ^@ http://purl.uniprot.org/uniprot/A2BK78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS01660 ^@ http://purl.uniprot.org/uniprot/A2BJM6 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/415426:HBUT_RS06895 ^@ http://purl.uniprot.org/uniprot/A2BMD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS02545 ^@ http://purl.uniprot.org/uniprot/A2BK39 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/415426:HBUT_RS07975 ^@ http://purl.uniprot.org/uniprot/A2BMY4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/415426:HBUT_RS08335 ^@ http://purl.uniprot.org/uniprot/A2BN51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 4 family.|||Binds 1 zinc ion per subunit.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/415426:HBUT_RS00820 ^@ http://purl.uniprot.org/uniprot/A2BJ70 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/415426:HBUT_RS01125 ^@ http://purl.uniprot.org/uniprot/A2BJC8 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/415426:HBUT_RS02755 ^@ http://purl.uniprot.org/uniprot/A2BK79 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS07980 ^@ http://purl.uniprot.org/uniprot/A2BMY5 ^@ Function|||Similarity ^@ Belongs to the ketopantoate reductase family.|||Catalyzes the NADPH-dependent reduction of ketopantoate into pantoic acid. http://togogenome.org/gene/415426:HBUT_RS06890 ^@ http://purl.uniprot.org/uniprot/A2BMD6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/415426:HBUT_RS02965 ^@ http://purl.uniprot.org/uniprot/A2BKC1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/415426:HBUT_RS03540 ^@ http://purl.uniprot.org/uniprot/A2BKM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/415426:HBUT_RS08580 ^@ http://purl.uniprot.org/uniprot/A2BN94 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/415426:HBUT_RS02250 ^@ http://purl.uniprot.org/uniprot/A2BJY7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/415426:HBUT_RS07995 ^@ http://purl.uniprot.org/uniprot/A2BMY8 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/415426:HBUT_RS04560 ^@ http://purl.uniprot.org/uniprot/A2BL57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/415426:HBUT_RS02295 ^@ http://purl.uniprot.org/uniprot/A2BJZ6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/415426:HBUT_RS03755 ^@ http://purl.uniprot.org/uniprot/A2BKR1 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||S-adenosyl-L-methionine-dependent methyltransferase that specifically methylates the C5 position of cytosine 72 in several tRNAs. http://togogenome.org/gene/415426:HBUT_RS08380 ^@ http://purl.uniprot.org/uniprot/A2BN60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/415426:HBUT_RS02880 ^@ http://purl.uniprot.org/uniprot/A2BKA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/415426:HBUT_RS08390 ^@ http://purl.uniprot.org/uniprot/A2BN62 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SPT5 family.|||Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/415426:HBUT_RS02975 ^@ http://purl.uniprot.org/uniprot/A2BKC3 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/415426:HBUT_RS01870 ^@ http://purl.uniprot.org/uniprot/A2BJR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS05925 ^@ http://purl.uniprot.org/uniprot/A2BLW2 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the TFE family.|||Monomer. Interaction with RNA polymerase subunits RpoF and RpoE is necessary for Tfe stimulatory transcription activity. Able to interact with Tbp and RNA polymerase in the absence of DNA promoter. Interacts both with the preinitiation and elongation complexes.|||The winged helix domain is involved in binding to DNA in the preinitiation complex.|||Transcription factor that plays a role in the activation of archaeal genes transcribed by RNA polymerase. Facilitates transcription initiation by enhancing TATA-box recognition by TATA-box-binding protein (Tbp), and transcription factor B (Tfb) and RNA polymerase recruitment. Not absolutely required for transcription in vitro, but particularly important in cases where Tbp or Tfb function is not optimal. It dynamically alters the nucleic acid-binding properties of RNA polymerases by stabilizing the initiation complex and destabilizing elongation complexes. Seems to translocate with the RNA polymerase following initiation and acts by binding to the non template strand of the transcription bubble in elongation complexes. http://togogenome.org/gene/415426:HBUT_RS00045 ^@ http://purl.uniprot.org/uniprot/A2BIT1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS04240 ^@ http://purl.uniprot.org/uniprot/A2BL01 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS05785 ^@ http://purl.uniprot.org/uniprot/A2BLU2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/415426:HBUT_RS03960 ^@ http://purl.uniprot.org/uniprot/A2BKU6 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/415426:HBUT_RS05840 ^@ http://purl.uniprot.org/uniprot/A2BLU9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/415426:HBUT_RS05735 ^@ http://purl.uniprot.org/uniprot/A2BLT2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS02740 ^@ http://purl.uniprot.org/uniprot/A2BK76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/415426:HBUT_RS03315 ^@ http://purl.uniprot.org/uniprot/A2BKI4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS05745 ^@ http://purl.uniprot.org/uniprot/A2BLT4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/415426:HBUT_RS03820 ^@ http://purl.uniprot.org/uniprot/A2BKS3 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/415426:HBUT_RS02235 ^@ http://purl.uniprot.org/uniprot/A2BJY4 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/415426:HBUT_RS00155 ^@ http://purl.uniprot.org/uniprot/A2BIV2 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/415426:HBUT_RS05390 ^@ http://purl.uniprot.org/uniprot/A2BLL5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/415426:HBUT_RS08195 ^@ http://purl.uniprot.org/uniprot/A2BN25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/415426:HBUT_RS04995 ^@ http://purl.uniprot.org/uniprot/A2BLE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS08400 ^@ http://purl.uniprot.org/uniprot/A2BN64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. Probably involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of its operon by binding to its mRNA. http://togogenome.org/gene/415426:HBUT_RS00185 ^@ http://purl.uniprot.org/uniprot/A2BIS3 ^@ Similarity ^@ Belongs to the Ahb/Nir family. http://togogenome.org/gene/415426:HBUT_RS01645 ^@ http://purl.uniprot.org/uniprot/A2BJM3 ^@ Similarity ^@ Belongs to the LDH2/MDH2 oxidoreductase family. http://togogenome.org/gene/415426:HBUT_RS00330 ^@ http://purl.uniprot.org/uniprot/A2BIY1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08375 ^@ http://purl.uniprot.org/uniprot/A2BN59 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin alpha subunit family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/415426:HBUT_RS08230 ^@ http://purl.uniprot.org/uniprot/A2BN32 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo5/eukaryotic RPB5 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS01050 ^@ http://purl.uniprot.org/uniprot/A2BJB3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/415426:HBUT_RS07845 ^@ http://purl.uniprot.org/uniprot/A2BMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS07470 ^@ http://purl.uniprot.org/uniprot/A2BMP3 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/415426:HBUT_RS03230 ^@ http://purl.uniprot.org/uniprot/A2BKG9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS04120 ^@ http://purl.uniprot.org/uniprot/A2BKX7 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/415426:HBUT_RS08105 ^@ http://purl.uniprot.org/uniprot/A2BN08 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/415426:HBUT_RS00980 ^@ http://purl.uniprot.org/uniprot/A2BJA2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS01965 ^@ http://purl.uniprot.org/uniprot/A2BJT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS07155 ^@ http://purl.uniprot.org/uniprot/A2BMI2 ^@ Similarity ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase large subunit family. http://togogenome.org/gene/415426:HBUT_RS00230 ^@ http://purl.uniprot.org/uniprot/A2BIW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tRNA-intron endonuclease family. Archaeal short subfamily.|||Endonuclease that removes tRNA introns. Cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3' cyclic phosphate and 5'-OH termini. Recognizes a pseudosymmetric substrate in which 2 bulged loops of 3 bases are separated by a stem of 4 bp.|||Homotetramer; although the tetramer contains four active sites, only two participate in the cleavage. Therefore, it should be considered as a dimer of dimers. http://togogenome.org/gene/415426:HBUT_RS03020 ^@ http://purl.uniprot.org/uniprot/A2BKD1 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/415426:HBUT_RS06165 ^@ http://purl.uniprot.org/uniprot/A2BM05 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/415426:HBUT_RS06525 ^@ http://purl.uniprot.org/uniprot/A2BM70 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/415426:HBUT_RS07905 ^@ http://purl.uniprot.org/uniprot/A2BMX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Forms a complex with TatC.|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system. http://togogenome.org/gene/415426:HBUT_RS00365 ^@ http://purl.uniprot.org/uniprot/A2BIY8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/415426:HBUT_RS08095 ^@ http://purl.uniprot.org/uniprot/A2BN06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the 'phage' integrase family. XerA subfamily.|||Cytoplasm|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. http://togogenome.org/gene/415426:HBUT_RS04820 ^@ http://purl.uniprot.org/uniprot/A2BLA5 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/415426:HBUT_RS06830 ^@ http://purl.uniprot.org/uniprot/A2BMC4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/415426:HBUT_RS08260 ^@ http://purl.uniprot.org/uniprot/A2BN38 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/415426:HBUT_RS05395 ^@ http://purl.uniprot.org/uniprot/A2BLL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/415426:HBUT_RS07425 ^@ http://purl.uniprot.org/uniprot/A2BMN4 ^@ Similarity ^@ Belongs to the MEMO1 family. http://togogenome.org/gene/415426:HBUT_RS08015 ^@ http://purl.uniprot.org/uniprot/A2BMZ2 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/415426:HBUT_RS08510 ^@ http://purl.uniprot.org/uniprot/A2BN82 ^@ Function|||Similarity ^@ Belongs to the FAU-1 family.|||Probable RNase involved in rRNA stability through maturation and/or degradation of precursor rRNAs. Binds to RNA in loop regions with AU-rich sequences. http://togogenome.org/gene/415426:HBUT_RS06150 ^@ http://purl.uniprot.org/uniprot/A2BM02 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/415426:HBUT_RS06480 ^@ http://purl.uniprot.org/uniprot/A2BM61 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/415426:HBUT_RS04410 ^@ http://purl.uniprot.org/uniprot/A2BL30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS08355 ^@ http://purl.uniprot.org/uniprot/A2BN55 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL39 family. http://togogenome.org/gene/415426:HBUT_RS08690 ^@ http://purl.uniprot.org/uniprot/A2BNB5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/415426:HBUT_RS02475 ^@ http://purl.uniprot.org/uniprot/A2BK27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/415426:HBUT_RS00925 ^@ http://purl.uniprot.org/uniprot/A2BJ92 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/415426:HBUT_RS04390 ^@ http://purl.uniprot.org/uniprot/A2BL26 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/415426:HBUT_RS07655 ^@ http://purl.uniprot.org/uniprot/A2BMS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS07795 ^@ http://purl.uniprot.org/uniprot/A2BMV0 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/415426:HBUT_RS05055 ^@ http://purl.uniprot.org/uniprot/A2BLF2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS07515 ^@ http://purl.uniprot.org/uniprot/A2BMQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS04105 ^@ http://purl.uniprot.org/uniprot/A2BKX4 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/415426:HBUT_RS04810 ^@ http://purl.uniprot.org/uniprot/A2BLA3 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/415426:HBUT_RS08385 ^@ http://purl.uniprot.org/uniprot/A2BN61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS02805 ^@ http://purl.uniprot.org/uniprot/A2BK89 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/415426:HBUT_RS03275 ^@ http://purl.uniprot.org/uniprot/A2BKH6 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/415426:HBUT_RS08600 ^@ http://purl.uniprot.org/uniprot/A2BN98 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/415426:HBUT_RS04395 ^@ http://purl.uniprot.org/uniprot/A2BL27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS00780 ^@ http://purl.uniprot.org/uniprot/A2BJ62 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/415426:HBUT_RS08655 ^@ http://purl.uniprot.org/uniprot/A2BNA8 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/415426:HBUT_RS04380 ^@ http://purl.uniprot.org/uniprot/A2BL24 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/415426:HBUT_RS05740 ^@ http://purl.uniprot.org/uniprot/A2BLT3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS02230 ^@ http://purl.uniprot.org/uniprot/A2BJY3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/415426:HBUT_RS00795 ^@ http://purl.uniprot.org/uniprot/A2BJ65 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/415426:HBUT_RS08190 ^@ http://purl.uniprot.org/uniprot/A2BN24 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/415426:HBUT_RS07505 ^@ http://purl.uniprot.org/uniprot/A2BMP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/415426:HBUT_RS05845 ^@ http://purl.uniprot.org/uniprot/A2BLV0 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/415426:HBUT_RS01670 ^@ http://purl.uniprot.org/uniprot/A2BJM8 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/415426:HBUT_RS00160 ^@ http://purl.uniprot.org/uniprot/A2BIV3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/415426:HBUT_RS02070 ^@ http://purl.uniprot.org/uniprot/A2BJV3 ^@ Caution|||Similarity ^@ Belongs to the thymidylate kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS00790 ^@ http://purl.uniprot.org/uniprot/A2BJ64 ^@ Similarity ^@ Belongs to the malic enzymes family. http://togogenome.org/gene/415426:HBUT_RS02745 ^@ http://purl.uniprot.org/uniprot/A2BK77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/415426:HBUT_RS00040 ^@ http://purl.uniprot.org/uniprot/A2BIT0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC61-beta family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS08870 ^@ http://purl.uniprot.org/uniprot/A2BKM9 ^@ Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. http://togogenome.org/gene/415426:HBUT_RS05620 ^@ http://purl.uniprot.org/uniprot/A2BLQ8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SurE nucleotidase family.|||Binds 1 divalent metal cation per subunit.|||Cytoplasm|||Nucleotidase that shows phosphatase activity on nucleoside 5'-monophosphates. http://togogenome.org/gene/415426:HBUT_RS02635 ^@ http://purl.uniprot.org/uniprot/A2BK57 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/415426:HBUT_RS05885 ^@ http://purl.uniprot.org/uniprot/A2BLV6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/415426:HBUT_RS03480 ^@ http://purl.uniprot.org/uniprot/A2BKL5 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/415426:HBUT_RS02935 ^@ http://purl.uniprot.org/uniprot/A2BKB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS06865 ^@ http://purl.uniprot.org/uniprot/A2BMD1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/415426:HBUT_RS02245 ^@ http://purl.uniprot.org/uniprot/A2BJY6 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS04710 ^@ http://purl.uniprot.org/uniprot/A2BL84 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/415426:HBUT_RS05935 ^@ http://purl.uniprot.org/uniprot/A2BLW4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS08395 ^@ http://purl.uniprot.org/uniprot/A2BN63 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/415426:HBUT_RS02970 ^@ http://purl.uniprot.org/uniprot/A2BKC2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS02215 ^@ http://purl.uniprot.org/uniprot/A2BJY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS01275 ^@ http://purl.uniprot.org/uniprot/A2BJF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS09105 ^@ http://purl.uniprot.org/uniprot/A2BN17 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/415426:HBUT_RS04865 ^@ http://purl.uniprot.org/uniprot/A2BLB4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/415426:HBUT_RS01725 ^@ http://purl.uniprot.org/uniprot/A2BJN8 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/415426:HBUT_RS03155 ^@ http://purl.uniprot.org/uniprot/A2BKF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS06290 ^@ http://purl.uniprot.org/uniprot/A2BM28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS04960 ^@ http://purl.uniprot.org/uniprot/A2BLD4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS00590 ^@ http://purl.uniprot.org/uniprot/A2BJ28 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS00505 ^@ http://purl.uniprot.org/uniprot/A2BJ11 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08350 ^@ http://purl.uniprot.org/uniprot/A2BN54 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/415426:HBUT_RS01170 ^@ http://purl.uniprot.org/uniprot/A2BJD5 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/415426:HBUT_RS06900 ^@ http://purl.uniprot.org/uniprot/A2BMD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/415426:HBUT_RS04490 ^@ http://purl.uniprot.org/uniprot/A2BL44 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase class-2 family.|||Catalyzes the reduction of ribonucleotides to deoxyribonucleotides. May function to provide a pool of deoxyribonucleotide precursors for DNA repair during oxygen limitation and/or for immediate growth after restoration of oxygen. http://togogenome.org/gene/415426:HBUT_RS08620 ^@ http://purl.uniprot.org/uniprot/A2BNA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS07285 ^@ http://purl.uniprot.org/uniprot/A2BMK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS02630 ^@ http://purl.uniprot.org/uniprot/A2BK56 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/415426:HBUT_RS07170 ^@ http://purl.uniprot.org/uniprot/A2BMI5 ^@ Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Heterodimer of a large and a small subunit. http://togogenome.org/gene/415426:HBUT_RS05695 ^@ http://purl.uniprot.org/uniprot/A2BLS4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/415426:HBUT_RS06360 ^@ http://purl.uniprot.org/uniprot/A2BM41 ^@ Caution|||Function|||Similarity ^@ Belongs to the Nre family.|||Involved in DNA damage repair.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS02600 ^@ http://purl.uniprot.org/uniprot/A2BK50 ^@ Similarity ^@ Belongs to the eIF-2B alpha/beta/delta subunits family. http://togogenome.org/gene/415426:HBUT_RS01835 ^@ http://purl.uniprot.org/uniprot/A2BJR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS04720 ^@ http://purl.uniprot.org/uniprot/A2BL86 ^@ Function|||Similarity ^@ Belongs to the THEP1 NTPase family.|||Has nucleotide phosphatase activity towards ATP, GTP, CTP, TTP and UTP. May hydrolyze nucleoside diphosphates with lower efficiency. http://togogenome.org/gene/415426:HBUT_RS08060 ^@ http://purl.uniprot.org/uniprot/A2BN00 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/415426:HBUT_RS07095 ^@ http://purl.uniprot.org/uniprot/A2BMH3 ^@ Function|||Similarity ^@ Belongs to the EF-1-beta/EF-1-delta family.|||Promotes the exchange of GDP for GTP in EF-1-alpha/GDP, thus allowing the regeneration of EF-1-alpha/GTP that could then be used to form the ternary complex EF-1-alpha/GTP/AAtRNA. http://togogenome.org/gene/415426:HBUT_RS07580 ^@ http://purl.uniprot.org/uniprot/A2BMR3 ^@ Similarity ^@ Belongs to the UbiD family. http://togogenome.org/gene/415426:HBUT_RS07400 ^@ http://purl.uniprot.org/uniprot/A2BMM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS03215 ^@ http://purl.uniprot.org/uniprot/A2BKG5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/415426:HBUT_RS04680 ^@ http://purl.uniprot.org/uniprot/A2BL78 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/415426:HBUT_RS07665 ^@ http://purl.uniprot.org/uniprot/A2BMS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS05545 ^@ http://purl.uniprot.org/uniprot/A2BLP3 ^@ Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/415426:HBUT_RS08240 ^@ http://purl.uniprot.org/uniprot/A2BN34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS08250 ^@ http://purl.uniprot.org/uniprot/A2BN36 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/415426:HBUT_RS01630 ^@ http://purl.uniprot.org/uniprot/A2BJM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS07490 ^@ http://purl.uniprot.org/uniprot/A2BMP6 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/415426:HBUT_RS00290 ^@ http://purl.uniprot.org/uniprot/A2BIX4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Cytoplasm|||Homodimer or homotetramer.|||Involved in the biosynthesis of polyamines which are thought to support the growth of thermophilic microorganisms under high-temperature conditions. It seems that long-chain and branched-chain of polyamines effectively stabilize DNA and RNA, respectively. Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to norspermidine, spermidine and norspermine to yield norspermine, thermospermine and caldopentamine, respectively. It can also synthesize sym-norspermidine (bis(3-aminopropyl)amine) from 1,3-diaminopropane with a very low activity. The biosynthesis of caldohexamine and caldoheptamine from caldopentamine has been also observed. http://togogenome.org/gene/415426:HBUT_RS07900 ^@ http://purl.uniprot.org/uniprot/A2BMW9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/415426:HBUT_RS03285 ^@ http://purl.uniprot.org/uniprot/A2BKH8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS02715 ^@ http://purl.uniprot.org/uniprot/A2BK73 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/415426:HBUT_RS02500 ^@ http://purl.uniprot.org/uniprot/A2BK31 ^@ Function|||Similarity ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. http://togogenome.org/gene/415426:HBUT_RS01260 ^@ http://purl.uniprot.org/uniprot/A2BJF0 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/415426:HBUT_RS05435 ^@ http://purl.uniprot.org/uniprot/A2BLM3 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/415426:HBUT_RS05115 ^@ http://purl.uniprot.org/uniprot/A2BLG5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06145 ^@ http://purl.uniprot.org/uniprot/A2BM01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS00335 ^@ http://purl.uniprot.org/uniprot/A2BIY2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS03720 ^@ http://purl.uniprot.org/uniprot/A2BKQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRISPR system Cmr5 family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS08995 ^@ http://purl.uniprot.org/uniprot/A2BM15 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the MRE11/RAD32 family.|||Binds 2 manganese ions per subunit.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nuclease activity is regulated by Rad50.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Mre11 binds to DSB ends and has both double-stranded 3'-5' exonuclease activity and single-stranded endonuclease activity. http://togogenome.org/gene/415426:HBUT_RS01710 ^@ http://purl.uniprot.org/uniprot/A2BJN5 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/415426:HBUT_RS08200 ^@ http://purl.uniprot.org/uniprot/A2BN26 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycerol-1-phosphate dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the NAD(P)H-dependent reduction of dihydroxyacetonephosphate (DHAP or glycerone phosphate) to glycerol 1-phosphate (G1P). The G1P thus generated is used as the glycerophosphate backbone of phospholipids in the cellular membranes of Archaea.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS00860 ^@ http://purl.uniprot.org/uniprot/A2BJ78 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/415426:HBUT_RS04675 ^@ http://purl.uniprot.org/uniprot/A2BL77 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 4 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS06265 ^@ http://purl.uniprot.org/uniprot/A2BM25 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group. http://togogenome.org/gene/415426:HBUT_RS00220 ^@ http://purl.uniprot.org/uniprot/A2BIW0 ^@ Caution|||Function|||Similarity ^@ Belongs to the UbiX/PAD1 family.|||Flavin prenyltransferase that catalyzes the synthesis of the prenylated FMN cofactor (prenyl-FMN) for 4-hydroxy-3-polyprenylbenzoic acid decarboxylase UbiD. The prenyltransferase is metal-independent and links a dimethylallyl moiety from dimethylallyl monophosphate (DMAP) to the flavin N5 and C6 atoms of FMN.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS06040 ^@ http://purl.uniprot.org/uniprot/A2BLY5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/415426:HBUT_RS05775 ^@ http://purl.uniprot.org/uniprot/A2BLU0 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/415426:HBUT_RS05945 ^@ http://purl.uniprot.org/uniprot/A2BLW6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase which is responsible for recognizing, binding, unfolding and translocation of substrate proteins into the archaeal 20S proteasome core particle. Is essential for opening the gate of the 20S proteasome via an interaction with its C-terminus, thereby allowing substrate entry and access to the site of proteolysis. Thus, the C-termini of the proteasomal ATPase function like a 'key in a lock' to induce gate opening and therefore regulate proteolysis. Unfolding activity requires energy from ATP hydrolysis, whereas ATP binding alone promotes ATPase-20S proteasome association which triggers gate opening, and supports translocation of unfolded substrates.|||Belongs to the AAA ATPase family.|||Consists of three main regions, an N-terminal coiled-coil domain that may assist in substrate recognition, an interdomain involved in PAN hexamerization, and a C-terminal ATPase domain of the AAA type.|||Cytoplasm|||Homohexamer. The hexameric complex has a two-ring architecture resembling a top hat that caps the 20S proteasome core at one or both ends. Upon ATP-binding, the C-terminus of PAN interacts with the alpha-rings of the proteasome core by binding to the intersubunit pockets. http://togogenome.org/gene/415426:HBUT_RS04745 ^@ http://purl.uniprot.org/uniprot/A2BL91 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/415426:HBUT_RS04665 ^@ http://purl.uniprot.org/uniprot/A2BL75 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 2 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/415426:HBUT_RS03590 ^@ http://purl.uniprot.org/uniprot/A2BKN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS00815 ^@ http://purl.uniprot.org/uniprot/A2BJ69 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/415426:HBUT_RS01745 ^@ http://purl.uniprot.org/uniprot/A2BJP2 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/415426:HBUT_RS02955 ^@ http://purl.uniprot.org/uniprot/A2BKB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRP4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Confers strong poly(A) specificity to the exosome. http://togogenome.org/gene/415426:HBUT_RS04430 ^@ http://purl.uniprot.org/uniprot/A2BL34 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/415426:HBUT_RS01940 ^@ http://purl.uniprot.org/uniprot/A2BJT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS03085 ^@ http://purl.uniprot.org/uniprot/A2BKE3 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/415426:HBUT_RS07560 ^@ http://purl.uniprot.org/uniprot/A2BMR0 ^@ Similarity ^@ Belongs to the PGI/PMI family. http://togogenome.org/gene/415426:HBUT_RS02280 ^@ http://purl.uniprot.org/uniprot/A2BJZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/415426:HBUT_RS07930 ^@ http://purl.uniprot.org/uniprot/A2BMX5 ^@ Similarity ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. http://togogenome.org/gene/415426:HBUT_RS06835 ^@ http://purl.uniprot.org/uniprot/A2BMC5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS07180 ^@ http://purl.uniprot.org/uniprot/A2BMI7 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/415426:HBUT_RS07105 ^@ http://purl.uniprot.org/uniprot/A2BMH5 ^@ Function|||Similarity ^@ Belongs to the PINc/VapC protein family.|||Toxic component of a toxin-antitoxin (TA) system. An RNase. http://togogenome.org/gene/415426:HBUT_RS01055 ^@ http://purl.uniprot.org/uniprot/A2BJB4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/415426:HBUT_RS08170 ^@ http://purl.uniprot.org/uniprot/A2BN20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS04265 ^@ http://purl.uniprot.org/uniprot/A2BL06 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06775 ^@ http://purl.uniprot.org/uniprot/A2BMB3 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/415426:HBUT_RS02435 ^@ http://purl.uniprot.org/uniprot/A2BK20 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS02800 ^@ http://purl.uniprot.org/uniprot/A2BK88 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/415426:HBUT_RS04660 ^@ http://purl.uniprot.org/uniprot/A2BL74 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/415426:HBUT_RS05930 ^@ http://purl.uniprot.org/uniprot/A2BLW3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/415426:HBUT_RS04100 ^@ http://purl.uniprot.org/uniprot/A2BKX3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/415426:HBUT_RS00235 ^@ http://purl.uniprot.org/uniprot/A2BIW3 ^@ Similarity ^@ Belongs to the UPF0111 family. http://togogenome.org/gene/415426:HBUT_RS01610 ^@ http://purl.uniprot.org/uniprot/A2BJL6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/415426:HBUT_RS06715 ^@ http://purl.uniprot.org/uniprot/A2BMA3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS07765 ^@ http://purl.uniprot.org/uniprot/A2BMU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08435 ^@ http://purl.uniprot.org/uniprot/A2BN71 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/415426:HBUT_RS08565 ^@ http://purl.uniprot.org/uniprot/A2BN92 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS04615 ^@ http://purl.uniprot.org/uniprot/A2BL67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of (R)-mevalonate (MVA) to (R)-mevalonate 5-phosphate (MVAP). Functions in the mevalonate (MVA) pathway leading to isopentenyl diphosphate (IPP), a key precursor for the biosynthesis of isoprenoid compounds such as archaeal membrane lipids.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS08685 ^@ http://purl.uniprot.org/uniprot/A2BNB4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/415426:HBUT_RS03110 ^@ http://purl.uniprot.org/uniprot/A2BKE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06885 ^@ http://purl.uniprot.org/uniprot/A2BMD5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/415426:HBUT_RS00030 ^@ http://purl.uniprot.org/uniprot/A2BIS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GGGP/HepGP synthase family. Group II subfamily.|||Cytoplasm|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C3 hydroxyl of sn-glycerol-1-phosphate (G1P). This reaction is the first ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/415426:HBUT_RS01625 ^@ http://purl.uniprot.org/uniprot/A2BJL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08205 ^@ http://purl.uniprot.org/uniprot/A2BN27 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/415426:HBUT_RS05640 ^@ http://purl.uniprot.org/uniprot/A2BLR3 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/415426:HBUT_RS01265 ^@ http://purl.uniprot.org/uniprot/A2BJF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS03580 ^@ http://purl.uniprot.org/uniprot/A2BKN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS03160 ^@ http://purl.uniprot.org/uniprot/A2BKF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS02535 ^@ http://purl.uniprot.org/uniprot/A2BK38 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/415426:HBUT_RS04930 ^@ http://purl.uniprot.org/uniprot/A2BLC7 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/415426:HBUT_RS01070 ^@ http://purl.uniprot.org/uniprot/A2BJB7 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/415426:HBUT_RS00260 ^@ http://purl.uniprot.org/uniprot/A2BIW8 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/415426:HBUT_RS03345 ^@ http://purl.uniprot.org/uniprot/A2BKJ0 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/415426:HBUT_RS00075 ^@ http://purl.uniprot.org/uniprot/A2BIT6 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/415426:HBUT_RS06745 ^@ http://purl.uniprot.org/uniprot/A2BMA8 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/415426:HBUT_RS05670 ^@ http://purl.uniprot.org/uniprot/A2BLR9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with geranylgeranyl diphosphate (GGPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30E,34E,38E)-undecaprenyl diphosphate (tritrans,heptacis-UPP). It is probably the precursor of glycosyl carrier lipids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS04700 ^@ http://purl.uniprot.org/uniprot/A2BL82 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/415426:HBUT_RS05035 ^@ http://purl.uniprot.org/uniprot/A2BLE9 ^@ Similarity ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily. http://togogenome.org/gene/415426:HBUT_RS05030 ^@ http://purl.uniprot.org/uniprot/A2BLE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6A family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/415426:HBUT_RS02575 ^@ http://purl.uniprot.org/uniprot/A2BK45 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/415426:HBUT_RS04775 ^@ http://purl.uniprot.org/uniprot/A2BL96 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/415426:HBUT_RS01760 ^@ http://purl.uniprot.org/uniprot/A2BJP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS08360 ^@ http://purl.uniprot.org/uniprot/A2BN56 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/415426:HBUT_RS03800 ^@ http://purl.uniprot.org/uniprot/A2BKR9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/415426:HBUT_RS08680 ^@ http://purl.uniprot.org/uniprot/A2BNB3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/415426:HBUT_RS02095 ^@ http://purl.uniprot.org/uniprot/A2BJV8 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/415426:HBUT_RS06240 ^@ http://purl.uniprot.org/uniprot/A2BM20 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/415426:HBUT_RS06925 ^@ http://purl.uniprot.org/uniprot/A2BME3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal adenylate kinase family.|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS00565 ^@ http://purl.uniprot.org/uniprot/A2BJ23 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/415426:HBUT_RS04715 ^@ http://purl.uniprot.org/uniprot/A2BL85 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/415426:HBUT_RS04870 ^@ http://purl.uniprot.org/uniprot/A2BLB5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the asparaginase 1 family. GatD subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/415426:HBUT_RS03295 ^@ http://purl.uniprot.org/uniprot/A2BKI0 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/415426:HBUT_RS02180 ^@ http://purl.uniprot.org/uniprot/A2BJX3 ^@ Similarity ^@ Belongs to the UPF0273 family. http://togogenome.org/gene/415426:HBUT_RS05065 ^@ http://purl.uniprot.org/uniprot/A2BLF4 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/415426:HBUT_RS01060 ^@ http://purl.uniprot.org/uniprot/A2BJB5 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/415426:HBUT_RS04740 ^@ http://purl.uniprot.org/uniprot/A2BL90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS08220 ^@ http://purl.uniprot.org/uniprot/A2BN30 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/415426:HBUT_RS05715 ^@ http://purl.uniprot.org/uniprot/A2BLS8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS02950 ^@ http://purl.uniprot.org/uniprot/A2BKB8 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/415426:HBUT_RS00055 ^@ http://purl.uniprot.org/uniprot/A2BIT3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aminocarboxypropyltransferase that catalyzes the aminocarboxypropyl transfer on pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. It constitutes the last step in biosynthesis of the hypermodified N1-methyl-N3-(3-amino-3-carboxypropyl) pseudouridine (m1acp3-Psi).|||Belongs to the TDD superfamily. TSR3 family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS02675 ^@ http://purl.uniprot.org/uniprot/A2BK65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS00255 ^@ http://purl.uniprot.org/uniprot/A2BIW7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm http://togogenome.org/gene/415426:HBUT_RS02820 ^@ http://purl.uniprot.org/uniprot/A2BK92 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/415426:HBUT_RS06095 ^@ http://purl.uniprot.org/uniprot/A2BLZ3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS00275 ^@ http://purl.uniprot.org/uniprot/A2BIX1 ^@ Caution|||Function|||Similarity ^@ Belongs to the TFIIB family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/415426:HBUT_RS08695 ^@ http://purl.uniprot.org/uniprot/A2BNB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/415426:HBUT_RS06920 ^@ http://purl.uniprot.org/uniprot/A2BME2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SecY/SEC61-alpha family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS01405 ^@ http://purl.uniprot.org/uniprot/A2BJH7 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/415426:HBUT_RS02360 ^@ http://purl.uniprot.org/uniprot/A2BK09 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the YjjX NTPase family.|||Binds 1 divalent metal cation per subunit; can use either Mg(2+) or Mn(2+).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Phosphatase that hydrolyzes non-canonical purine nucleotides such as XTP and ITP to their respective diphosphate derivatives. Probably excludes non-canonical purines from DNA/RNA precursor pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/415426:HBUT_RS07250 ^@ http://purl.uniprot.org/uniprot/A2BMK0 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/415426:HBUT_RS05665 ^@ http://purl.uniprot.org/uniprot/A2BLR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/415426:HBUT_RS02585 ^@ http://purl.uniprot.org/uniprot/A2BK47 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/415426:HBUT_RS08365 ^@ http://purl.uniprot.org/uniprot/A2BN57 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/415426:HBUT_RS01130 ^@ http://purl.uniprot.org/uniprot/A2BJC9 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/415426:HBUT_RS07145 ^@ http://purl.uniprot.org/uniprot/A2BMI0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/415426:HBUT_RS04130 ^@ http://purl.uniprot.org/uniprot/A2BKX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/415426:HBUT_RS08610 ^@ http://purl.uniprot.org/uniprot/A2BN99 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/415426:HBUT_RS06915 ^@ http://purl.uniprot.org/uniprot/A2BME1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS07445 ^@ http://purl.uniprot.org/uniprot/A2BMN8 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/415426:HBUT_RS06910 ^@ http://purl.uniprot.org/uniprot/A2BME0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS04135 ^@ http://purl.uniprot.org/uniprot/A2BKY0 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/415426:HBUT_RS02385 ^@ http://purl.uniprot.org/uniprot/A2BK13 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/415426:HBUT_RS08725 ^@ http://purl.uniprot.org/uniprot/A2BNC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 4-toluene sulfonate uptake permease (TSUP) (TC 2.A.102) family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS02355 ^@ http://purl.uniprot.org/uniprot/A2BK08 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS00435 ^@ http://purl.uniprot.org/uniprot/A2BIZ8 ^@ Function|||Similarity ^@ Belongs to the AdoMet synthase 2 family.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/415426:HBUT_RS02265 ^@ http://purl.uniprot.org/uniprot/A2BJZ0 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS02285 ^@ http://purl.uniprot.org/uniprot/A2BJZ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/415426:HBUT_RS08255 ^@ http://purl.uniprot.org/uniprot/A2BN37 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/415426:HBUT_RS00090 ^@ http://purl.uniprot.org/uniprot/A2BIT9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/415426:HBUT_RS05305 ^@ http://purl.uniprot.org/uniprot/A2BLK1 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/415426:HBUT_RS04785 ^@ http://purl.uniprot.org/uniprot/A2BL98 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/415426:HBUT_RS02780 ^@ http://purl.uniprot.org/uniprot/A2BK84 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/415426:HBUT_RS03390 ^@ http://purl.uniprot.org/uniprot/A2BKJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/415426:HBUT_RS07525 ^@ http://purl.uniprot.org/uniprot/A2BMQ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS00010 ^@ http://purl.uniprot.org/uniprot/A2BIS6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06945 ^@ http://purl.uniprot.org/uniprot/A2BME7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/415426:HBUT_RS02795 ^@ http://purl.uniprot.org/uniprot/A2BK87 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/415426:HBUT_RS05560 ^@ http://purl.uniprot.org/uniprot/A2BLP5 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/415426:HBUT_RS00175 ^@ http://purl.uniprot.org/uniprot/A2BIS1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS03475 ^@ http://purl.uniprot.org/uniprot/A2BKL4 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/415426:HBUT_RS05410 ^@ http://purl.uniprot.org/uniprot/A2BLL9 ^@ Similarity ^@ In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family. http://togogenome.org/gene/415426:HBUT_RS00270 ^@ http://purl.uniprot.org/uniprot/A2BIX0 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/415426:HBUT_RS03305 ^@ http://purl.uniprot.org/uniprot/A2BKI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/415426:HBUT_RS00885 ^@ http://purl.uniprot.org/uniprot/A2BJ83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/415426:HBUT_RS02680 ^@ http://purl.uniprot.org/uniprot/A2BK66 ^@ Function|||Similarity ^@ Belongs to the peptidase S9C family.|||This enzyme catalyzes the hydrolysis of the N-terminal peptide bond of an N-acetylated peptide to generate an N-acetylated amino acid and a peptide with a free N-terminus. It preferentially cleaves off Ac-Ala, Ac-Met and Ac-Ser. http://togogenome.org/gene/415426:HBUT_RS04125 ^@ http://purl.uniprot.org/uniprot/A2BKX8 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/415426:HBUT_RS06220 ^@ http://purl.uniprot.org/uniprot/A2BM16 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the SMC family. RAD50 subfamily.|||Binds 1 zinc ion per homodimer.|||Homodimer. Forms a heterotetramer composed of two Mre11 subunits and two Rad50 subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the Rad50/Mre11 complex, which is involved in the early steps of DNA double-strand break (DSB) repair. The complex may facilitate opening of the processed DNA ends to aid in the recruitment of HerA and NurA. Rad50 controls the balance between DNA end bridging and DNA resection via ATP-dependent structural rearrangements of the Rad50/Mre11 complex.|||The two conserved Cys that bind zinc constitute the zinc-hook, which separates the large intramolecular coiled coil regions. The 2 Cys residues coordinate one molecule of zinc with the help of the 2 Cys residues of the zinc-hook of another Rad50 molecule, thereby forming a V-shaped homodimer. http://togogenome.org/gene/415426:HBUT_RS08575 ^@ http://purl.uniprot.org/uniprot/A2BN93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2-alpha family.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/415426:HBUT_RS08275 ^@ http://purl.uniprot.org/uniprot/A2BN41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/415426:HBUT_RS05495 ^@ http://purl.uniprot.org/uniprot/A2BLN4 ^@ Cofactor ^@ Binds 4 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/415426:HBUT_RS08245 ^@ http://purl.uniprot.org/uniprot/A2BN35 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms part of the jaw domain.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS06700 ^@ http://purl.uniprot.org/uniprot/A2BMA0 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/415426:HBUT_RS08270 ^@ http://purl.uniprot.org/uniprot/A2BN40 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS01095 ^@ http://purl.uniprot.org/uniprot/A2BJC2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS04760 ^@ http://purl.uniprot.org/uniprot/A2BL93 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/415426:HBUT_RS04600 ^@ http://purl.uniprot.org/uniprot/A2BL64 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/415426:HBUT_RS02695 ^@ http://purl.uniprot.org/uniprot/A2BK69 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/415426:HBUT_RS06995 ^@ http://purl.uniprot.org/uniprot/A2BMF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/415426:HBUT_RS06620 ^@ http://purl.uniprot.org/uniprot/A2BM88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell membrane|||Membrane http://togogenome.org/gene/415426:HBUT_RS00560 ^@ http://purl.uniprot.org/uniprot/A2BJ22 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/415426:HBUT_RS05110 ^@ http://purl.uniprot.org/uniprot/A2BLG4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/415426:HBUT_RS04485 ^@ http://purl.uniprot.org/uniprot/A2BL43 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/415426:HBUT_RS04815 ^@ http://purl.uniprot.org/uniprot/A2BLA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/415426:HBUT_RS06850 ^@ http://purl.uniprot.org/uniprot/A2BMC8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/415426:HBUT_RS04385 ^@ http://purl.uniprot.org/uniprot/A2BL25 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/415426:HBUT_RS02025 ^@ http://purl.uniprot.org/uniprot/A2BJU4 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/415426:HBUT_RS02195 ^@ http://purl.uniprot.org/uniprot/A2BJX6 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. Can use ATP, ADP and GTP, but not CTP, TTP or NAD(+). http://togogenome.org/gene/415426:HBUT_RS05430 ^@ http://purl.uniprot.org/uniprot/A2BLM2 ^@ Similarity ^@ Belongs to the AP endonuclease 2 family. http://togogenome.org/gene/415426:HBUT_RS04620 ^@ http://purl.uniprot.org/uniprot/A2BL68 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/415426:HBUT_RS01685 ^@ http://purl.uniprot.org/uniprot/A2BJN0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/415426:HBUT_RS08225 ^@ http://purl.uniprot.org/uniprot/A2BN31 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/415426:HBUT_RS00475 ^@ http://purl.uniprot.org/uniprot/A2BJ05 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/415426:HBUT_RS01665 ^@ http://purl.uniprot.org/uniprot/A2BJM7 ^@ Similarity ^@ Belongs to the transcriptional regulatory CopG/NikR family. http://togogenome.org/gene/415426:HBUT_RS04895 ^@ http://purl.uniprot.org/uniprot/A2BLC0 ^@ Cofactor|||Function|||Similarity ^@ Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration (By similarity).|||Binds 1 potassium ion per subunit.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.