http://togogenome.org/gene/453591:IGNI_RS05645 ^@ http://purl.uniprot.org/uniprot/A8ABH2 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/453591:IGNI_RS00555 ^@ http://purl.uniprot.org/uniprot/A8A8N6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ThiC family.|||Binds 1 [4Fe-4S] cluster per subunit. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the synthesis of the hydroxymethylpyrimidine phosphate (HMP-P) moiety of thiamine from aminoimidazole ribotide (AIR) in a radical S-adenosyl-L-methionine (SAM)-dependent reaction. http://togogenome.org/gene/453591:IGNI_RS02075 ^@ http://purl.uniprot.org/uniprot/A8A9I2 ^@ Similarity ^@ Belongs to the CutA family. http://togogenome.org/gene/453591:IGNI_RS01945 ^@ http://purl.uniprot.org/uniprot/A8A9F7 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. UPF0219 family. http://togogenome.org/gene/453591:IGNI_RS04105 ^@ http://purl.uniprot.org/uniprot/A8AAM6 ^@ Similarity ^@ Belongs to the GPN-loop GTPase family. http://togogenome.org/gene/453591:IGNI_RS02945 ^@ http://purl.uniprot.org/uniprot/A8A9Z6 ^@ Similarity ^@ Belongs to the isopentenyl phosphate kinase family. http://togogenome.org/gene/453591:IGNI_RS04620 ^@ http://purl.uniprot.org/uniprot/A8AAX5 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/453591:IGNI_RS04540 ^@ http://purl.uniprot.org/uniprot/A8AAW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/453591:IGNI_RS03320 ^@ http://purl.uniprot.org/uniprot/A8AA67 ^@ Function ^@ Catalyzes the synthesis of GMP from XMP. http://togogenome.org/gene/453591:IGNI_RS04865 ^@ http://purl.uniprot.org/uniprot/A8AB24 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/453591:IGNI_RS03635 ^@ http://purl.uniprot.org/uniprot/A8AAD2 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/453591:IGNI_RS01260 ^@ http://purl.uniprot.org/uniprot/A8A925 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds at least 2 Zn(2+) per subunit.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Forms the clamp head domain.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/453591:IGNI_RS04740 ^@ http://purl.uniprot.org/uniprot/A8AAZ9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell inner membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity. http://togogenome.org/gene/453591:IGNI_RS05710 ^@ http://purl.uniprot.org/uniprot/A8ABI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 2 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS01640 ^@ http://purl.uniprot.org/uniprot/A8A998 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. PoK subfamily.|||Phosphorylates (R)-pantoate to form (R)-4-phosphopantoate in the CoA biosynthesis pathway. http://togogenome.org/gene/453591:IGNI_RS03230 ^@ http://purl.uniprot.org/uniprot/A8AA51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. LysZ subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. Phosphorylates the LysW-bound precursors glutamate (for arginine biosynthesis), respectively alpha-aminoadipate (for lysine biosynthesis). http://togogenome.org/gene/453591:IGNI_RS04940 ^@ http://purl.uniprot.org/uniprot/A8AB39 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS04100 ^@ http://purl.uniprot.org/uniprot/A8AAM5 ^@ Similarity ^@ Belongs to the CTAG/PCC1 family. http://togogenome.org/gene/453591:IGNI_RS07350 ^@ http://purl.uniprot.org/uniprot/A8ACE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Homodimer.|||Involved in the de novo purine biosynthesis. Catalyzes the transfer of formate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR). Formate is provided by PurU via hydrolysis of 10-formyl-tetrahydrofolate. http://togogenome.org/gene/453591:IGNI_RS06530 ^@ http://purl.uniprot.org/uniprot/A8ABZ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS03525 ^@ http://purl.uniprot.org/uniprot/A8AAA9 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal beta chain is a regulatory subunit. http://togogenome.org/gene/453591:IGNI_RS03000 ^@ http://purl.uniprot.org/uniprot/A8AA07 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CSL4 family.|||Component of the archaeal exosome complex. Forms a trimer of Rrp4 and/or Csl4 subunits. The trimer associates with an hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. Interacts with DnaG.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Increases the RNA binding and the efficiency of RNA degradation. Helpful for the interaction of the exosome with A-poor RNAs. http://togogenome.org/gene/453591:IGNI_RS04990 ^@ http://purl.uniprot.org/uniprot/A8AB48 ^@ Similarity ^@ Belongs to the sulfate adenylyltransferase family. http://togogenome.org/gene/453591:IGNI_RS06925 ^@ http://purl.uniprot.org/uniprot/A8AC64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/453591:IGNI_RS03945 ^@ http://purl.uniprot.org/uniprot/A8AAJ5 ^@ Similarity ^@ Belongs to the eIF-2-alpha family. http://togogenome.org/gene/453591:IGNI_RS03895 ^@ http://purl.uniprot.org/uniprot/A8AAI4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/453591:IGNI_RS05100 ^@ http://purl.uniprot.org/uniprot/A8AB68 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS06585 ^@ http://purl.uniprot.org/uniprot/A8AC04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/453591:IGNI_RS00965 ^@ http://purl.uniprot.org/uniprot/A8A8W6 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL18 family. http://togogenome.org/gene/453591:IGNI_RS06555 ^@ http://purl.uniprot.org/uniprot/A8ABZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS06975 ^@ http://purl.uniprot.org/uniprot/A8AC73 ^@ Function|||Miscellaneous|||Similarity ^@ Belongs to the L-aspartate dehydrogenase family.|||Specifically catalyzes the NAD or NADP-dependent dehydrogenation of L-aspartate to iminoaspartate.|||The iminoaspartate product is unstable in aqueous solution and can decompose to oxaloacetate and ammonia. http://togogenome.org/gene/453591:IGNI_RS02875 ^@ http://purl.uniprot.org/uniprot/A8A9Y4 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS04495 ^@ http://purl.uniprot.org/uniprot/A8AAV1 ^@ Similarity ^@ Belongs to the myo-inositol 1-phosphate synthase family. http://togogenome.org/gene/453591:IGNI_RS07775 ^@ http://purl.uniprot.org/uniprot/A8AAU4 ^@ Similarity ^@ Belongs to the Nth/MutY family. http://togogenome.org/gene/453591:IGNI_RS06065 ^@ http://purl.uniprot.org/uniprot/A8ABQ4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt5 family.|||Heterodimer composed of Spt4 and Spt5. Interacts with RNA polymerase (RNAP).|||Stimulates transcription elongation. http://togogenome.org/gene/453591:IGNI_RS07100 ^@ http://purl.uniprot.org/uniprot/A8AC95 ^@ Similarity ^@ Belongs to the arginase family. http://togogenome.org/gene/453591:IGNI_RS02110 ^@ http://purl.uniprot.org/uniprot/A8A9I9 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/453591:IGNI_RS04385 ^@ http://purl.uniprot.org/uniprot/A8AAS9 ^@ Function|||Miscellaneous|||Similarity|||Subunit ^@ A single active site specifically recognizes both ATP and CTP and is responsible for their addition.|||Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. Archaeal CCA-adding enzyme subfamily.|||Catalyzes the addition and repair of the essential 3'-terminal CCA sequence in tRNAs without using a nucleic acid template. Adds these three nucleotides in the order of C, C, and A to the tRNA nucleotide-73, using CTP and ATP as substrates and producing inorganic pyrophosphate.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS02640 ^@ http://purl.uniprot.org/uniprot/A8A9U2 ^@ Similarity ^@ Belongs to the UPF0282 family. http://togogenome.org/gene/453591:IGNI_RS05780 ^@ http://purl.uniprot.org/uniprot/A8ABJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the aTrm56 family.|||Cytoplasm|||Homodimer.|||Specifically catalyzes the AdoMet-dependent 2'-O-ribose methylation of cytidine at position 56 in tRNAs. http://togogenome.org/gene/453591:IGNI_RS02930 ^@ http://purl.uniprot.org/uniprot/A8A9Z3 ^@ Cofactor ^@ Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/453591:IGNI_RS00935 ^@ http://purl.uniprot.org/uniprot/A8A8W0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. BUD32 family. http://togogenome.org/gene/453591:IGNI_RS04095 ^@ http://purl.uniprot.org/uniprot/A8AAM4 ^@ Function ^@ Probably involved in the biogenesis of the ribosome. http://togogenome.org/gene/453591:IGNI_RS07095 ^@ http://purl.uniprot.org/uniprot/A8AC94 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M54 family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic, whereas the other seems to have a structural role.|||Monomer.|||Probable zinc metalloprotease whose natural substrate is unknown. http://togogenome.org/gene/453591:IGNI_RS04715 ^@ http://purl.uniprot.org/uniprot/A8AAZ4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/453591:IGNI_RS00455 ^@ http://purl.uniprot.org/uniprot/A8A8L6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Forms 2 domains with an elongated structure; Rpo4 packs into the hinge region between the 2 domains.|||Nucleus|||Part of the RNA polymerase complex. Forms a stalk with Rpo4 that extends from the main structure. http://togogenome.org/gene/453591:IGNI_RS05555 ^@ http://purl.uniprot.org/uniprot/A8ABF5 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/453591:IGNI_RS01040 ^@ http://purl.uniprot.org/uniprot/A8A8Y1 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/453591:IGNI_RS05805 ^@ http://purl.uniprot.org/uniprot/A8ABK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Cytoplasm|||Functions by promoting the formation of the first peptide bond. http://togogenome.org/gene/453591:IGNI_RS06695 ^@ http://purl.uniprot.org/uniprot/A8AC23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcS subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/453591:IGNI_RS07370 ^@ http://purl.uniprot.org/uniprot/A8ACE3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine. http://togogenome.org/gene/453591:IGNI_RS05340 ^@ http://purl.uniprot.org/uniprot/A8ABB4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNase Z family.|||Binds 2 Zn(2+) ions.|||Homodimer.|||Zinc phosphodiesterase, which displays some tRNA 3'-processing endonuclease activity. Probably involved in tRNA maturation, by removing a 3'-trailer from precursor tRNA. http://togogenome.org/gene/453591:IGNI_RS02350 ^@ http://purl.uniprot.org/uniprot/A8A9N4 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/453591:IGNI_RS05925 ^@ http://purl.uniprot.org/uniprot/A8ABM7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DtdA deacylase family.|||Binds 2 Zn(2+) ions per subunit.|||D-aminoacyl-tRNA deacylase with broad substrate specificity. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS01770 ^@ http://purl.uniprot.org/uniprot/A8A9C3 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase Pus10 family.|||Responsible for synthesis of pseudouridine from uracil-54 and uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/453591:IGNI_RS05450 ^@ http://purl.uniprot.org/uniprot/A8ABD5 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/453591:IGNI_RS06950 ^@ http://purl.uniprot.org/uniprot/A8AC69 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Heterodimer composed of a glutamine amidotransferase subunit (A) and a GMP-binding subunit (B). http://togogenome.org/gene/453591:IGNI_RS00240 ^@ http://purl.uniprot.org/uniprot/A8A8H5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/453591:IGNI_RS05560 ^@ http://purl.uniprot.org/uniprot/A8ABF6 ^@ Similarity ^@ Belongs to the V-ATPase F subunit family. http://togogenome.org/gene/453591:IGNI_RS07320 ^@ http://purl.uniprot.org/uniprot/A8ACD3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||Located at the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS06300 ^@ http://purl.uniprot.org/uniprot/A8ABU6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS00230 ^@ http://purl.uniprot.org/uniprot/A8A8H3 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/453591:IGNI_RS00945 ^@ http://purl.uniprot.org/uniprot/A8A8W2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/453591:IGNI_RS07120 ^@ http://purl.uniprot.org/uniprot/A8AC98 ^@ Function|||Similarity ^@ Belongs to the BPG-independent phosphoglycerate mutase family. A-PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/453591:IGNI_RS00305 ^@ http://purl.uniprot.org/uniprot/A8A8I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS00570 ^@ http://purl.uniprot.org/uniprot/A8A8N9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/453591:IGNI_RS04515 ^@ http://purl.uniprot.org/uniprot/A8AAV5 ^@ Caution|||Function|||Similarity ^@ Belongs to the MqnA/MqnD family. MqnD subfamily.|||Catalyzes the conversion of cyclic dehypoxanthine futalosine (cyclic DHFL) into 1,4-dihydroxy-6-naphthoate, a step in the biosynthesis of menaquinone (MK, vitamin K2).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS00340 ^@ http://purl.uniprot.org/uniprot/A8A8J4 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/453591:IGNI_RS03575 ^@ http://purl.uniprot.org/uniprot/A8AAC0 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/453591:IGNI_RS03985 ^@ http://purl.uniprot.org/uniprot/A8AAK3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/453591:IGNI_RS04390 ^@ http://purl.uniprot.org/uniprot/A8AAT0 ^@ Function|||Similarity ^@ Belongs to the 2H phosphoesterase superfamily. ThpR family.|||Hydrolyzes RNA 2',3'-cyclic phosphodiester to an RNA 2'-phosphomonoester. http://togogenome.org/gene/453591:IGNI_RS06480 ^@ http://purl.uniprot.org/uniprot/A8ABY3 ^@ Subunit ^@ Heterodimer composed of an alpha and a beta subunit. http://togogenome.org/gene/453591:IGNI_RS00170 ^@ http://purl.uniprot.org/uniprot/A8A8G2 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/453591:IGNI_RS03210 ^@ http://purl.uniprot.org/uniprot/A8AA47 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the ferredoxin--NADP reductase type 2 family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS02680 ^@ http://purl.uniprot.org/uniprot/A8A9U9 ^@ Function|||Similarity ^@ Belongs to the EIF-2B alpha/beta/delta subunits family. MtnA subfamily.|||Catalyzes the interconversion of methylthioribose-1-phosphate (MTR-1-P) into methylthioribulose-1-phosphate (MTRu-1-P). http://togogenome.org/gene/453591:IGNI_RS05950 ^@ http://purl.uniprot.org/uniprot/A8ABN0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation. http://togogenome.org/gene/453591:IGNI_RS00955 ^@ http://purl.uniprot.org/uniprot/A8A8W4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS02775 ^@ http://purl.uniprot.org/uniprot/A8A9W6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS03860 ^@ http://purl.uniprot.org/uniprot/A8AAH7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal MetE family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group to L-homocysteine resulting in methionine formation. The physiological methyl donor is unknown. http://togogenome.org/gene/453591:IGNI_RS04355 ^@ http://purl.uniprot.org/uniprot/A8AAS3 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/453591:IGNI_RS03415 ^@ http://purl.uniprot.org/uniprot/A8AA87 ^@ Similarity ^@ Belongs to the diphthine synthase family. http://togogenome.org/gene/453591:IGNI_RS00310 ^@ http://purl.uniprot.org/uniprot/A8A8I9 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/453591:IGNI_RS00960 ^@ http://purl.uniprot.org/uniprot/A8A8W5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the RNA polymerase complex. http://togogenome.org/gene/453591:IGNI_RS05590 ^@ http://purl.uniprot.org/uniprot/A8ABG2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/453591:IGNI_RS03905 ^@ http://purl.uniprot.org/uniprot/A8AAI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 2 subfamily.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS04440 ^@ http://purl.uniprot.org/uniprot/A8AAU0 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS05205 ^@ http://purl.uniprot.org/uniprot/A8AB88 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS07455 ^@ http://purl.uniprot.org/uniprot/A8ACF9 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Aspartyl-tRNA synthetase with relaxed tRNA specificity since it is able to aspartylate not only its cognate tRNA(Asp) but also tRNA(Asn). Reaction proceeds in two steps: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp/Asn).|||Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Binds 3 Mg(2+) cations per subunit. The strongest magnesium site (Mg1) is bound to the beta- and gamma-phosphates of ATP and four water molecules complete its coordination sphere.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS07260 ^@ http://purl.uniprot.org/uniprot/A8ACC3 ^@ Subunit ^@ Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/453591:IGNI_RS01095 ^@ http://purl.uniprot.org/uniprot/A8A8Z1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase PH family. Rrp42 subfamily.|||Component of the archaeal exosome complex. Forms a hexameric ring-like arrangement composed of 3 Rrp41-Rrp42 heterodimers. The hexameric ring associates with a trimer of Rrp4 and/or Csl4 subunits.|||Cytoplasm|||Non-catalytic component of the exosome, which is a complex involved in RNA degradation. Contributes to the structuring of the Rrp41 active site. http://togogenome.org/gene/453591:IGNI_RS03580 ^@ http://purl.uniprot.org/uniprot/A8AAC1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the XPG/RAD2 endonuclease family. FEN1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Interacts with PCNA. PCNA stimulates the nuclease activity without altering cleavage specificity.|||Structure-specific nuclease with 5'-flap endonuclease and 5'-3' exonuclease activities involved in DNA replication and repair. During DNA replication, cleaves the 5'-overhanging flap structure that is generated by displacement synthesis when DNA polymerase encounters the 5'-end of a downstream Okazaki fragment. Binds the unpaired 3'-DNA end and kinks the DNA to facilitate 5' cleavage specificity. Cleaves one nucleotide into the double-stranded DNA from the junction in flap DNA, leaving a nick for ligation. Also involved in the base excision repair (BER) pathway. Acts as a genome stabilization factor that prevents flaps from equilibrating into structures that lead to duplications and deletions. Also possesses 5'-3' exonuclease activity on nicked or gapped double-stranded DNA (By similarity). http://togogenome.org/gene/453591:IGNI_RS00235 ^@ http://purl.uniprot.org/uniprot/A8A8H4 ^@ Cofactor ^@ Binds 1 [2Fe-2S] cluster per subunit. http://togogenome.org/gene/453591:IGNI_RS02150 ^@ http://purl.uniprot.org/uniprot/A8A9J6 ^@ Similarity ^@ Belongs to the archaeal-type GPI family. http://togogenome.org/gene/453591:IGNI_RS01400 ^@ http://purl.uniprot.org/uniprot/A8A953 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS24 family. http://togogenome.org/gene/453591:IGNI_RS06315 ^@ http://purl.uniprot.org/uniprot/A8ABV0 ^@ Similarity ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 2 subfamily. http://togogenome.org/gene/453591:IGNI_RS00165 ^@ http://purl.uniprot.org/uniprot/A8A8G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS03610 ^@ http://purl.uniprot.org/uniprot/A8AAC7 ^@ Similarity ^@ Belongs to the SDO1/SBDS family. http://togogenome.org/gene/453591:IGNI_RS07280 ^@ http://purl.uniprot.org/uniprot/A8ACC7 ^@ Similarity ^@ Belongs to the RimK family. LysX subfamily. http://togogenome.org/gene/453591:IGNI_RS07355 ^@ http://purl.uniprot.org/uniprot/A8ACE1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the methyltransferase superfamily. Fibrillarin family.|||Interacts with nop5. Component of box C/D small ribonucleoprotein (sRNP) particles that contain rpl7ae, FlpA and nop5, plus a guide RNA.|||Involved in pre-rRNA and tRNA processing. Utilizes the methyl donor S-adenosyl-L-methionine to catalyze the site-specific 2'-hydroxyl methylation of ribose moieties in rRNA and tRNA. Site specificity is provided by a guide RNA that base pairs with the substrate. Methylation occurs at a characteristic distance from the sequence involved in base pairing with the guide RNA. http://togogenome.org/gene/453591:IGNI_RS05135 ^@ http://purl.uniprot.org/uniprot/A8AB75 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family.|||Catalyzes the first step of diphthamide biosynthesis, i.e. the transfer of the 3-amino-3-carboxypropyl group from S-adenosyl-L-methionine (SAM) to the C2 position of the imidazole ring of the target histidine residue in translation elongation factor 2 (EF-2). http://togogenome.org/gene/453591:IGNI_RS06590 ^@ http://purl.uniprot.org/uniprot/A8AC05 ^@ Similarity ^@ Belongs to the SUI1 family. http://togogenome.org/gene/453591:IGNI_RS00055 ^@ http://purl.uniprot.org/uniprot/A8A8D9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/453591:IGNI_RS05405 ^@ http://purl.uniprot.org/uniprot/A8ABC6 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/453591:IGNI_RS06290 ^@ http://purl.uniprot.org/uniprot/A8ABU4 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/453591:IGNI_RS03555 ^@ http://purl.uniprot.org/uniprot/A8AAB6 ^@ Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the prokaryotic AdoMetDC family. Type 1 subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Heterooctamer of four alpha and four beta chains arranged as a tetramer of alpha/beta heterodimers.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The post-translation cleavage follows an unusual pathway, termed non-hydrolytic serinolysis, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl group blocking the N-terminus of the alpha chain.|||Specifically catalyzes the decarboxylation of L-arginine to agmatine. Has no S-adenosylmethionine decarboxylase (AdoMetDC) activity. http://togogenome.org/gene/453591:IGNI_RS04405 ^@ http://purl.uniprot.org/uniprot/A8AAT4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication.|||Sliding clamp subunit. Responsible for tethering the catalytic subunit of DNA polymerase to DNA during high-speed replication. http://togogenome.org/gene/453591:IGNI_RS01880 ^@ http://purl.uniprot.org/uniprot/A8A9E4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the FBP aldolase/phosphatase family.|||Catalyzes two subsequent steps in gluconeogenesis: the aldol condensation of dihydroxyacetone phosphate (DHAP) and glyceraldehyde-3-phosphate (GA3P) to fructose-1,6-bisphosphate (FBP), and the dephosphorylation of FBP to fructose-6-phosphate (F6P).|||Consists of a single catalytic domain, but remodels its active-site architecture via a large structural change to exhibit dual activities.|||Homooctamer; dimer of tetramers. http://togogenome.org/gene/453591:IGNI_RS04285 ^@ http://purl.uniprot.org/uniprot/A8AAQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CitM (TC 2.A.11) transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/453591:IGNI_RS01755 ^@ http://purl.uniprot.org/uniprot/A8A9B9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/453591:IGNI_RS05725 ^@ http://purl.uniprot.org/uniprot/A8ABI8 ^@ Function|||Similarity ^@ Belongs to the PEP-utilizing enzyme family.|||Catalyzes the phosphorylation of pyruvate to phosphoenolpyruvate. http://togogenome.org/gene/453591:IGNI_RS02155 ^@ http://purl.uniprot.org/uniprot/A8A9J7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. DGGGP synthase subfamily.|||Cell membrane|||Prenyltransferase that catalyzes the transfer of the geranylgeranyl moiety of geranylgeranyl diphosphate (GGPP) to the C2 hydroxyl of (S)-3-O-geranylgeranylglyceryl phosphate (GGGP). This reaction is the second ether-bond-formation step in the biosynthesis of archaeal membrane lipids. http://togogenome.org/gene/453591:IGNI_RS02295 ^@ http://purl.uniprot.org/uniprot/A8A9M3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the ATP- and formate-dependent formylation of 5-aminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (AICAR) to 5-formaminoimidazole-4-carboxamide-1-beta-d-ribofuranosyl 5'-monophosphate (FAICAR) in the absence of folates. http://togogenome.org/gene/453591:IGNI_RS02480 ^@ http://purl.uniprot.org/uniprot/A8A9R0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS00370 ^@ http://purl.uniprot.org/uniprot/A8A8J9 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/453591:IGNI_RS02805 ^@ http://purl.uniprot.org/uniprot/A8A9X2 ^@ Similarity ^@ In the C-terminal section; belongs to the complex I 49 kDa subunit family. http://togogenome.org/gene/453591:IGNI_RS00795 ^@ http://purl.uniprot.org/uniprot/A8A8T5 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/453591:IGNI_RS06685 ^@ http://purl.uniprot.org/uniprot/A8AC21 ^@ Similarity ^@ Belongs to the MCM family. http://togogenome.org/gene/453591:IGNI_RS06905 ^@ http://purl.uniprot.org/uniprot/A8AC61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/453591:IGNI_RS02380 ^@ http://purl.uniprot.org/uniprot/A8A9P0 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. Prx6 subfamily.|||Cytoplasm|||Homodecamer. Pentamer of dimers that assemble into a ring structure.|||The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. Although the primary sequence of this enzyme is similar to those of the 1-Cys Prx6 enzymes, its catalytic properties resemble those of the typical 2-Cys Prxs and C(R) is provided by the other dimeric subunit to form an intersubunit disulfide. The disulfide is subsequently reduced by thioredoxin.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/453591:IGNI_RS03120 ^@ http://purl.uniprot.org/uniprot/A8AA30 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/453591:IGNI_RS04945 ^@ http://purl.uniprot.org/uniprot/A8AB40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS01375 ^@ http://purl.uniprot.org/uniprot/A8A948 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. http://togogenome.org/gene/453591:IGNI_RS00015 ^@ http://purl.uniprot.org/uniprot/A8A8D3 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Function in general translation initiation by promoting the binding of the formylmethionine-tRNA to ribosomes. Seems to function along with eIF-2. http://togogenome.org/gene/453591:IGNI_RS01010 ^@ http://purl.uniprot.org/uniprot/A8A8X5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS25 family. http://togogenome.org/gene/453591:IGNI_RS03060 ^@ http://purl.uniprot.org/uniprot/A8AA18 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/453591:IGNI_RS02140 ^@ http://purl.uniprot.org/uniprot/A8A9J4 ^@ Similarity ^@ Belongs to the HypD family. http://togogenome.org/gene/453591:IGNI_RS05015 ^@ http://purl.uniprot.org/uniprot/A8AB53 ^@ Similarity ^@ Belongs to the PstS family. http://togogenome.org/gene/453591:IGNI_RS05145 ^@ http://purl.uniprot.org/uniprot/A8AB77 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wyosine derivatives biosynthesis pathway. Probably methylates N-4 position of wybutosine-86 to produce wybutosine-72. http://togogenome.org/gene/453591:IGNI_RS04980 ^@ http://purl.uniprot.org/uniprot/A8AB46 ^@ Function|||Similarity ^@ Belongs to the APS kinase family.|||Catalyzes the synthesis of activated sulfate. http://togogenome.org/gene/453591:IGNI_RS05150 ^@ http://purl.uniprot.org/uniprot/A8AB78 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/453591:IGNI_RS04410 ^@ http://purl.uniprot.org/uniprot/A8AAT5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase small subunit family.|||Catalytic subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. The small subunit contains the primase catalytic core and has DNA synthesis activity on its own. Binding to the large subunit stabilizes and modulates the activity, increasing the rate of DNA synthesis while decreasing the length of the DNA fragments, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/453591:IGNI_RS05295 ^@ http://purl.uniprot.org/uniprot/A8ABA5 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/453591:IGNI_RS05355 ^@ http://purl.uniprot.org/uniprot/A8ABB6 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal FAD synthase family.|||Catalyzes the transfer of the AMP portion of ATP to flavin mononucleotide (FMN) to produce flavin adenine dinucleotide (FAD) coenzyme.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS06605 ^@ http://purl.uniprot.org/uniprot/A8AC08 ^@ Function|||Similarity ^@ Belongs to the archaeal SPP-like hydrolase family.|||Catalyzes the dephosphorylation of 2-phosphoglycolate. http://togogenome.org/gene/453591:IGNI_RS00220 ^@ http://purl.uniprot.org/uniprot/A8A8H1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable chromatin protein, binds double-strand DNA without sequence specificity. Constrains negative DNA supercoils.|||Belongs to the Cren7 family.|||Cytoplasm|||Methylated at multiple sites, to varying extents.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS02750 ^@ http://purl.uniprot.org/uniprot/A8A9W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS04735 ^@ http://purl.uniprot.org/uniprot/A8AAZ8 ^@ Similarity ^@ Belongs to the gamma-glutamylcyclotransferase family. http://togogenome.org/gene/453591:IGNI_RS03690 ^@ http://purl.uniprot.org/uniprot/A8AAE3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PCNA family.|||Homotrimer. The subunits circularize to form a toroid; DNA passes through its center. Replication factor C (RFC) is required to load the toroid on the DNA.|||Sliding clamp subunit that acts as a moving platform for DNA processing. Responsible for tethering the catalytic subunit of DNA polymerase and other proteins to DNA during high-speed replication. http://togogenome.org/gene/453591:IGNI_RS01600 ^@ http://purl.uniprot.org/uniprot/A8A990 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent agmatine transferase that catalyzes the formation of 2-agmatinylcytidine (agm2C) at the wobble position (C34) of tRNA(Ile2), converting the codon specificity from AUG to AUA.|||Belongs to the TiaS family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS02040 ^@ http://purl.uniprot.org/uniprot/A8A9H6 ^@ Similarity ^@ Belongs to the peptidase C56 family. http://togogenome.org/gene/453591:IGNI_RS00975 ^@ http://purl.uniprot.org/uniprot/A8A8W8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/453591:IGNI_RS04955 ^@ http://purl.uniprot.org/uniprot/A8AB42 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L24e. http://togogenome.org/gene/453591:IGNI_RS06955 ^@ http://purl.uniprot.org/uniprot/A8AC70 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/453591:IGNI_RS00950 ^@ http://purl.uniprot.org/uniprot/A8A8W3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/453591:IGNI_RS06700 ^@ http://purl.uniprot.org/uniprot/A8AC24 ^@ Function|||Similarity|||Subunit ^@ Belongs to the activator 1 small subunits family. RfcL subfamily.|||Heteromultimer composed of small subunits (RfcS) and large subunits (RfcL).|||Part of the RFC clamp loader complex which loads the PCNA sliding clamp onto DNA. http://togogenome.org/gene/453591:IGNI_RS04185 ^@ http://purl.uniprot.org/uniprot/A8AAP3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the prefoldin subunit beta family.|||Cytoplasm|||Heterohexamer of two alpha and four beta subunits.|||Molecular chaperone capable of stabilizing a range of proteins. Seems to fulfill an ATP-independent, HSP70-like function in archaeal de novo protein folding. http://togogenome.org/gene/453591:IGNI_RS06485 ^@ http://purl.uniprot.org/uniprot/A8ABY4 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/453591:IGNI_RS02955 ^@ http://purl.uniprot.org/uniprot/A8A9Z8 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/453591:IGNI_RS03205 ^@ http://purl.uniprot.org/uniprot/A8AA46 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/453591:IGNI_RS02030 ^@ http://purl.uniprot.org/uniprot/A8A9H4 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS04765 ^@ http://purl.uniprot.org/uniprot/A8AB04 ^@ Similarity ^@ Belongs to the TrpF family. http://togogenome.org/gene/453591:IGNI_RS04060 ^@ http://purl.uniprot.org/uniprot/A8AAL8 ^@ Similarity ^@ Belongs to the SIS family. PHI subfamily. http://togogenome.org/gene/453591:IGNI_RS03080 ^@ http://purl.uniprot.org/uniprot/A8AA22 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/453591:IGNI_RS01470 ^@ http://purl.uniprot.org/uniprot/A8A966 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/453591:IGNI_RS04845 ^@ http://purl.uniprot.org/uniprot/A8AB20 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent DNA ligase family.|||DNA ligase that seals nicks in double-stranded DNA during DNA replication, DNA recombination and DNA repair. http://togogenome.org/gene/453591:IGNI_RS01980 ^@ http://purl.uniprot.org/uniprot/A8A9G4 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/453591:IGNI_RS03940 ^@ http://purl.uniprot.org/uniprot/A8AAJ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-archaeol synthase family.|||Catalyzes the formation of CDP-2,3-bis-(O-geranylgeranyl)-sn-glycerol (CDP-archaeol) from 2,3-bis-(O-geranylgeranyl)-sn-glycerol 1-phosphate (DGGGP) and CTP. This reaction is the third ether-bond-formation step in the biosynthesis of archaeal membrane lipids.|||Cell membrane http://togogenome.org/gene/453591:IGNI_RS04140 ^@ http://purl.uniprot.org/uniprot/A8AAN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS04360 ^@ http://purl.uniprot.org/uniprot/A8AAS4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PurS family.|||Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/453591:IGNI_RS00080 ^@ http://purl.uniprot.org/uniprot/A8A8E4 ^@ Function|||Similarity ^@ Activates the tRNA-splicing ligase complex by facilitating the enzymatic turnover of catalytic subunit RtcB. Acts by promoting the guanylylation of RtcB, a key intermediate step in tRNA ligation. Can also alter the NTP specificity of RtcB such that ATP, dGTP or ITP is used efficiently.|||Belongs to the archease family. http://togogenome.org/gene/453591:IGNI_RS06070 ^@ http://purl.uniprot.org/uniprot/A8ABQ5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/453591:IGNI_RS05605 ^@ http://purl.uniprot.org/uniprot/A8ABG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TOP6B family.|||Homodimer. Heterotetramer of two Top6A and two Top6B chains.|||Relaxes both positive and negative superturns and exhibits a strong decatenase activity. http://togogenome.org/gene/453591:IGNI_RS05040 ^@ http://purl.uniprot.org/uniprot/A8AB57 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL37 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA. http://togogenome.org/gene/453591:IGNI_RS01290 ^@ http://purl.uniprot.org/uniprot/A8A931 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS04875 ^@ http://purl.uniprot.org/uniprot/A8AB26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal NMN adenylyltransferase family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS07880 ^@ http://purl.uniprot.org/uniprot/A8AAA8 ^@ Similarity ^@ Belongs to the class-I fumarase family. http://togogenome.org/gene/453591:IGNI_RS04535 ^@ http://purl.uniprot.org/uniprot/A8AAV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS06205 ^@ http://purl.uniprot.org/uniprot/A8ABS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/453591:IGNI_RS05235 ^@ http://purl.uniprot.org/uniprot/A8AB94 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/453591:IGNI_RS01270 ^@ http://purl.uniprot.org/uniprot/A8A927 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/453591:IGNI_RS05610 ^@ http://purl.uniprot.org/uniprot/A8ABG6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with a modified folate serving as the one-carbon carrier. Also exhibits a pteridine-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS00915 ^@ http://purl.uniprot.org/uniprot/A8A8V6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase may regulate its activity.|||Belongs to the histone-like Alba family.|||Binds double-stranded DNA tightly but without sequence specificity. It is distributed uniformly and abundantly on the chromosome, suggesting a role in chromatin architecture. However, it does not significantly compact DNA. Binds rRNA and mRNA in vivo. May play a role in maintaining the structural and functional stability of RNA, and, perhaps, ribosomes.|||Chromosome|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/453591:IGNI_RS03540 ^@ http://purl.uniprot.org/uniprot/A8AAB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS02820 ^@ http://purl.uniprot.org/uniprot/A8A9X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS02340 ^@ http://purl.uniprot.org/uniprot/A8A9N2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the 50S ribosomal subunit. Homodimer, it forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Forms a heptameric L10(L12)2(L12)2(L12)2 complex, where L10 forms an elongated spine to which the L12 dimers bind in a sequential fashion. http://togogenome.org/gene/453591:IGNI_RS01275 ^@ http://purl.uniprot.org/uniprot/A8A928 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NusA family.|||Cytoplasm|||Participates in transcription termination. http://togogenome.org/gene/453591:IGNI_RS06650 ^@ http://purl.uniprot.org/uniprot/A8AC17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/453591:IGNI_RS03605 ^@ http://purl.uniprot.org/uniprot/A8AAC6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homotetramer; dimer of dimers.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS00515 ^@ http://purl.uniprot.org/uniprot/A8A8M8 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/453591:IGNI_RS03195 ^@ http://purl.uniprot.org/uniprot/A8AA44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS06060 ^@ http://purl.uniprot.org/uniprot/A8ABQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY (alpha), SecG (beta) and SecE (gamma) subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. May interact with SecDF, and other proteins may be involved.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation.|||Membrane http://togogenome.org/gene/453591:IGNI_RS02165 ^@ http://purl.uniprot.org/uniprot/A8A9J9 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/453591:IGNI_RS05885 ^@ http://purl.uniprot.org/uniprot/A8ABL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS00225 ^@ http://purl.uniprot.org/uniprot/A8A8H2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/453591:IGNI_RS04455 ^@ http://purl.uniprot.org/uniprot/A8AAU3 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS1 family. http://togogenome.org/gene/453591:IGNI_RS00870 ^@ http://purl.uniprot.org/uniprot/A8A8U9 ^@ Similarity ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily. http://togogenome.org/gene/453591:IGNI_RS00985 ^@ http://purl.uniprot.org/uniprot/A8A8X0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/453591:IGNI_RS01675 ^@ http://purl.uniprot.org/uniprot/A8A9A5 ^@ Similarity|||Subunit ^@ Belongs to the ALAD family.|||Homooctamer. http://togogenome.org/gene/453591:IGNI_RS05620 ^@ http://purl.uniprot.org/uniprot/A8ABG8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL33 family. http://togogenome.org/gene/453591:IGNI_RS00940 ^@ http://purl.uniprot.org/uniprot/A8A8W1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/453591:IGNI_RS05520 ^@ http://purl.uniprot.org/uniprot/A8ABE8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/453591:IGNI_RS01725 ^@ http://purl.uniprot.org/uniprot/A8A9B3 ^@ Similarity ^@ Belongs to the radical SAM superfamily. Anaerobic sulfatase-maturating enzyme family. http://togogenome.org/gene/453591:IGNI_RS06575 ^@ http://purl.uniprot.org/uniprot/A8AC02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL19 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS05995 ^@ http://purl.uniprot.org/uniprot/A8ABP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo8 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/453591:IGNI_RS03140 ^@ http://purl.uniprot.org/uniprot/A8AA33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAC-alpha family.|||Contacts the emerging nascent chain on the ribosome.|||Homodimer. Interacts with the ribosome. Binds ribosomal RNA. http://togogenome.org/gene/453591:IGNI_RS01570 ^@ http://purl.uniprot.org/uniprot/A8A984 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/453591:IGNI_RS02355 ^@ http://purl.uniprot.org/uniprot/A8A9N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS07335 ^@ http://purl.uniprot.org/uniprot/A8ACD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS02285 ^@ http://purl.uniprot.org/uniprot/A8A9M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS00120 ^@ http://purl.uniprot.org/uniprot/A8A8F2 ^@ Similarity ^@ Belongs to the UPF0047 family. http://togogenome.org/gene/453591:IGNI_RS02665 ^@ http://purl.uniprot.org/uniprot/A8A9U6 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Both the DNA unwinding and positive supercoiling activities require the cooperation of both domains. The cooperative action between the helicase-like and the topoisomerase domains is specific. The helicase-like domain probably does not directly unwind DNA but acts more likely by driving ATP-dependent conformational changes within the whole enzyme, functioning more like a protein motor. The 'latch' region of the N-terminal domain plays a regulatory role in the enzyme, repressing topoisomerase activity in the absence of ATP and therefore preventing the enzyme from acting as an ATP-independent relaxing enzyme; it also helps to coordinate nucleotide hydrolysis by the ATPase domain with the supercoiling activity of the topoisomerase domain.|||In the C-terminal section; belongs to the prokaryotic type I/III topoisomerase family.|||In the N-terminal section; belongs to the DEAD box helicase family. DDVD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modifies the topological state of DNA by introducing positive supercoils in an ATP-dependent process. It cleaves transiently a single DNA strand and remains covalently bound to the 5' DNA end through a tyrosine residue. May be involved in rewinding the DNA strands in the regions of the chromosome that have opened up to allow transcription or replication.|||Monomer.|||This enzyme is the only unique feature of hyperthermophilic bacteria/archaea discovered so far. It appears to be essential for adaptation to life at high temperatures. http://togogenome.org/gene/453591:IGNI_RS01560 ^@ http://purl.uniprot.org/uniprot/A8A982 ^@ Similarity ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. Type 4 (UDGa) family. http://togogenome.org/gene/453591:IGNI_RS06500 ^@ http://purl.uniprot.org/uniprot/A8ABY7 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. http://togogenome.org/gene/453591:IGNI_RS02420 ^@ http://purl.uniprot.org/uniprot/A8A9P8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/453591:IGNI_RS01910 ^@ http://purl.uniprot.org/uniprot/A8A9F0 ^@ Function ^@ Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of both single-stranded RNA (ssRNA) and single-stranded DNA (ssDNA). Exhibits a strong preference for ssRNA. http://togogenome.org/gene/453591:IGNI_RS01750 ^@ http://purl.uniprot.org/uniprot/A8A9B8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endonuclease V family.|||Cytoplasm|||DNA repair enzyme involved in the repair of deaminated bases. Selectively cleaves double-stranded DNA at the second phosphodiester bond 3' to a deoxyinosine leaving behind the intact lesion on the nicked DNA. http://togogenome.org/gene/453591:IGNI_RS06170 ^@ http://purl.uniprot.org/uniprot/A8ABS1 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/453591:IGNI_RS02915 ^@ http://purl.uniprot.org/uniprot/A8A9Z0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the THI4 family.|||Homooctamer; tetramer of dimers.|||Involved in the biosynthesis of the thiazole moiety of thiamine. Catalyzes the conversion of NAD and glycine to adenosine diphosphate 5-(2-hydroxyethyl)-4-methylthiazole-2-carboxylate (ADT), an adenylated thiazole intermediate, using free sulfide as a source of sulfur.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS00785 ^@ http://purl.uniprot.org/uniprot/A8A8T3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Cytoplasm|||DNA-dependent RNA polymerase (RNAP) catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Part of the RNA polymerase complex. http://togogenome.org/gene/453591:IGNI_RS05155 ^@ http://purl.uniprot.org/uniprot/A8AB79 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS05060 ^@ http://purl.uniprot.org/uniprot/A8AB61 ^@ Function|||Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate). http://togogenome.org/gene/453591:IGNI_RS01485 ^@ http://purl.uniprot.org/uniprot/A8A969 ^@ Function|||Similarity ^@ Belongs to the eIF-6 family.|||Binds to the 50S ribosomal subunit and prevents its association with the 30S ribosomal subunit to form the 70S initiation complex. http://togogenome.org/gene/453591:IGNI_RS00970 ^@ http://purl.uniprot.org/uniprot/A8A8W7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/453591:IGNI_RS05915 ^@ http://purl.uniprot.org/uniprot/A8ABM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/453591:IGNI_RS07075 ^@ http://purl.uniprot.org/uniprot/A8AC90 ^@ Similarity|||Subunit ^@ Belongs to the [NiFe]/[NiFeSe] hydrogenase small subunit family.|||Heterodimer of a large and a small subunit. http://togogenome.org/gene/453591:IGNI_RS07270 ^@ http://purl.uniprot.org/uniprot/A8ACC5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/453591:IGNI_RS00575 ^@ http://purl.uniprot.org/uniprot/A8A8P0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/453591:IGNI_RS02730 ^@ http://purl.uniprot.org/uniprot/A8A9V8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NrfD family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS03295 ^@ http://purl.uniprot.org/uniprot/A8AA62 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/453591:IGNI_RS04775 ^@ http://purl.uniprot.org/uniprot/A8AB06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS07325 ^@ http://purl.uniprot.org/uniprot/A8ACD4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS4 family. http://togogenome.org/gene/453591:IGNI_RS07435 ^@ http://purl.uniprot.org/uniprot/A8ACF7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TYW1 family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Component of the wyosine derivatives biosynthesis pathway that catalyzes the condensation of N-methylguanine with 2 carbon atoms from pyruvate to form the tricyclic 4-demethylwyosine (imG-14) on guanosine-37 of tRNA(Phe).|||Cytoplasm|||Monomer. http://togogenome.org/gene/453591:IGNI_RS06970 ^@ http://purl.uniprot.org/uniprot/A8AC72 ^@ Similarity ^@ Belongs to the desulfoferrodoxin family. http://togogenome.org/gene/453591:IGNI_RS06980 ^@ http://purl.uniprot.org/uniprot/A8AC74 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NadC/ModD family.|||Hexamer formed by 3 homodimers.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/453591:IGNI_RS02830 ^@ http://purl.uniprot.org/uniprot/A8A9X7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the archaeal riboflavin kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the CTP-dependent phosphorylation of riboflavin (vitamin B2) to form flavin mononucleotide (FMN). http://togogenome.org/gene/453591:IGNI_RS00670 ^@ http://purl.uniprot.org/uniprot/A8A8R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0056 (MarC) family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/453591:IGNI_RS00765 ^@ http://purl.uniprot.org/uniprot/A8A8S9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS06825 ^@ http://purl.uniprot.org/uniprot/A8AC48 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS04120 ^@ http://purl.uniprot.org/uniprot/A8AAM9 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Membrane http://togogenome.org/gene/453591:IGNI_RS06725 ^@ http://purl.uniprot.org/uniprot/A8AC29 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The archaeal alpha chain is a catalytic subunit. http://togogenome.org/gene/453591:IGNI_RS06425 ^@ http://purl.uniprot.org/uniprot/A8ABX2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 2 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/453591:IGNI_RS06675 ^@ http://purl.uniprot.org/uniprot/A8AC19 ^@ Function|||Similarity ^@ Belongs to the CDC6/cdc18 family.|||Involved in regulation of DNA replication. http://togogenome.org/gene/453591:IGNI_RS02645 ^@ http://purl.uniprot.org/uniprot/A8A9U3 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/453591:IGNI_RS04965 ^@ http://purl.uniprot.org/uniprot/A8AB44 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||Binds to 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29. http://togogenome.org/gene/453591:IGNI_RS07400 ^@ http://purl.uniprot.org/uniprot/A8ACE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Consists of a catalytic RNA component and at least 4-5 protein subunits.|||Cytoplasm|||Part of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends. http://togogenome.org/gene/453591:IGNI_RS03615 ^@ http://purl.uniprot.org/uniprot/A8AAC8 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the radical SAM superfamily. MoaA family.|||Binds 2 [4Fe-4S] clusters. Binds 1 [4Fe-4S] cluster coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine and 1 [4Fe-4S] cluster coordinated with 3 cysteines and the GTP-derived substrate.|||Catalyzes the cyclization of GTP to (8S)-3',8-cyclo-7,8-dihydroguanosine 5'-triphosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS00335 ^@ http://purl.uniprot.org/uniprot/A8A8J3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the archaeal DnaG primase family.|||Binds two Mg(2+) per subunit.|||Forms a ternary complex with MCM helicase and DNA. Component of the archaeal exosome complex.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Also part of the exosome, which is a complex involved in RNA degradation. Acts as a poly(A)-binding protein that enhances the interaction between heteromeric, adenine-rich transcripts and the exosome. http://togogenome.org/gene/453591:IGNI_RS00780 ^@ http://purl.uniprot.org/uniprot/A8A8T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS00145 ^@ http://purl.uniprot.org/uniprot/A8A8F7 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/453591:IGNI_RS05660 ^@ http://purl.uniprot.org/uniprot/A8ABH5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/453591:IGNI_RS06055 ^@ http://purl.uniprot.org/uniprot/A8ABQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cell membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/453591:IGNI_RS00550 ^@ http://purl.uniprot.org/uniprot/A8A8N5 ^@ Cofactor|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eS27 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/453591:IGNI_RS02505 ^@ http://purl.uniprot.org/uniprot/A8A9R5 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/453591:IGNI_RS01465 ^@ http://purl.uniprot.org/uniprot/A8A965 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS19 family.|||May be involved in maturation of the 30S ribosomal subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS02025 ^@ http://purl.uniprot.org/uniprot/A8A9H3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/453591:IGNI_RS06020 ^@ http://purl.uniprot.org/uniprot/A8ABP5 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/453591:IGNI_RS01150 ^@ http://purl.uniprot.org/uniprot/A8A903 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/453591:IGNI_RS00100 ^@ http://purl.uniprot.org/uniprot/A8A8E8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/453591:IGNI_RS03765 ^@ http://purl.uniprot.org/uniprot/A8AAF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily. LysY sub-subfamily.|||Cytoplasm|||Involved in both the arginine and lysine biosynthetic pathways. http://togogenome.org/gene/453591:IGNI_RS00665 ^@ http://purl.uniprot.org/uniprot/A8A8Q9 ^@ Similarity ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase TrmH family. http://togogenome.org/gene/453591:IGNI_RS04570 ^@ http://purl.uniprot.org/uniprot/A8AAW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS03070 ^@ http://purl.uniprot.org/uniprot/A8AA20 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS04815 ^@ http://purl.uniprot.org/uniprot/A8AB14 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/453591:IGNI_RS06570 ^@ http://purl.uniprot.org/uniprot/A8AC01 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/453591:IGNI_RS00460 ^@ http://purl.uniprot.org/uniprot/A8A8L7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/453591:IGNI_RS05830 ^@ http://purl.uniprot.org/uniprot/A8ABK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/453591:IGNI_RS00285 ^@ http://purl.uniprot.org/uniprot/A8A8I4 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/453591:IGNI_RS00245 ^@ http://purl.uniprot.org/uniprot/A8A8H6 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.|||Heterooligomer of catalytic and regulatory chains. http://togogenome.org/gene/453591:IGNI_RS00425 ^@ http://purl.uniprot.org/uniprot/A8A8L0 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Heterodimer of a small subunit (PriS) and a large subunit (PriL).|||Regulatory subunit of DNA primase, an RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. Stabilizes and modulates the activity of the small subunit, increasing the rate of DNA synthesis, and conferring RNA synthesis capability. The DNA polymerase activity may enable DNA primase to also catalyze primer extension after primer synthesis. May also play a role in DNA repair. http://togogenome.org/gene/453591:IGNI_RS06230 ^@ http://purl.uniprot.org/uniprot/A8ABT2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS00675 ^@ http://purl.uniprot.org/uniprot/A8A8R1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TmcA family.|||Catalyzes the formation of N(4)-acetylcytidine (ac(4)C) at the wobble position of tRNA(Met), by using acetyl-CoA as an acetyl donor and ATP (or GTP).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus http://togogenome.org/gene/453591:IGNI_RS03065 ^@ http://purl.uniprot.org/uniprot/A8AA19 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/453591:IGNI_RS01165 ^@ http://purl.uniprot.org/uniprot/A8A906 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Catalyzes the deamination of dCTP to dUTP.|||Homotrimer. http://togogenome.org/gene/453591:IGNI_RS02535 ^@ http://purl.uniprot.org/uniprot/A8A9S1 ^@ Similarity ^@ Belongs to the HypE family. http://togogenome.org/gene/453591:IGNI_RS03360 ^@ http://purl.uniprot.org/uniprot/A8AA75 ^@ Similarity ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. http://togogenome.org/gene/453591:IGNI_RS01670 ^@ http://purl.uniprot.org/uniprot/A8A9A4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EIF2G subfamily.|||Heterotrimer composed of an alpha, a beta and a gamma chain.|||eIF-2 functions in the early steps of protein synthesis by forming a ternary complex with GTP and initiator tRNA. http://togogenome.org/gene/453591:IGNI_RS01405 ^@ http://purl.uniprot.org/uniprot/A8A954 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS17 family. http://togogenome.org/gene/453591:IGNI_RS05690 ^@ http://purl.uniprot.org/uniprot/A8ABI1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL42 family.|||Binds 1 zinc ion per subunit.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS01625 ^@ http://purl.uniprot.org/uniprot/A8A995 ^@ Similarity ^@ Belongs to the CcmF/CycK/Ccl1/NrfE/CcsA family. http://togogenome.org/gene/453591:IGNI_RS04090 ^@ http://purl.uniprot.org/uniprot/A8AAM3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL43 family. Putative zinc-binding subfamily.|||Binds to the 23S rRNA.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS01125 ^@ http://purl.uniprot.org/uniprot/A8A8Z7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA). http://togogenome.org/gene/453591:IGNI_RS07165 ^@ http://purl.uniprot.org/uniprot/A8ACA7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS05045 ^@ http://purl.uniprot.org/uniprot/A8AB58 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome core, a large protease complex with broad specificity involved in protein degradation.|||Cytoplasm|||The 20S proteasome core is composed of 14 alpha and 14 beta subunits that assemble into four stacked heptameric rings, resulting in a barrel-shaped structure. The two inner rings, each composed of seven catalytic beta subunits, are sandwiched by two outer rings, each composed of seven alpha subunits. The catalytic chamber with the active sites is on the inside of the barrel. Has a gated structure, the ends of the cylinder being occluded by the N-termini of the alpha-subunits. Is capped at one or both ends by the proteasome regulatory ATPase, PAN.|||The formation of the proteasomal ATPase PAN-20S proteasome complex, via the docking of the C-termini of PAN into the intersubunit pockets in the alpha-rings, triggers opening of the gate for substrate entry. Interconversion between the open-gate and close-gate conformations leads to a dynamic regulation of the 20S proteasome proteolysis activity. http://togogenome.org/gene/453591:IGNI_RS04665 ^@ http://purl.uniprot.org/uniprot/A8AAY4 ^@ Similarity ^@ Belongs to the glutaredoxin family. http://togogenome.org/gene/453591:IGNI_RS00990 ^@ http://purl.uniprot.org/uniprot/A8A8X1 ^@ Function ^@ Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/453591:IGNI_RS06490 ^@ http://purl.uniprot.org/uniprot/A8ABY5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL14 family. http://togogenome.org/gene/453591:IGNI_RS05115 ^@ http://purl.uniprot.org/uniprot/A8AB71 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/453591:IGNI_RS06580 ^@ http://purl.uniprot.org/uniprot/A8AC03 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/453591:IGNI_RS03445 ^@ http://purl.uniprot.org/uniprot/A8AA94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family. LysK subfamily.|||Binds 2 Zn(2+) or Co(2+) ions per subunit.|||Catalyzes the release of L-lysine from [LysW]-gamma-L-lysine and the release of L-ornithine from [LysW]-L-ornithine.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS05075 ^@ http://purl.uniprot.org/uniprot/A8AB65 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/453591:IGNI_RS01415 ^@ http://purl.uniprot.org/uniprot/A8A956 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS04730 ^@ http://purl.uniprot.org/uniprot/A8AAZ7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the class IV-like SAM-binding methyltransferase superfamily. RNA methyltransferase NEP1 family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase involved in ribosomal biogenesis. Specifically catalyzes the N1-methylation of the pseudouridine corresponding to position 914 in M.jannaschii 16S rRNA. http://togogenome.org/gene/453591:IGNI_RS06985 ^@ http://purl.uniprot.org/uniprot/A8AC75 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS00810 ^@ http://purl.uniprot.org/uniprot/A8A8T8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/453591:IGNI_RS04145 ^@ http://purl.uniprot.org/uniprot/A8AAN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP). http://togogenome.org/gene/453591:IGNI_RS00450 ^@ http://purl.uniprot.org/uniprot/A8A8L5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal Spt4 family.|||Heterodimer composed of Spt4 and Spt5.|||Stimulates transcription elongation. http://togogenome.org/gene/453591:IGNI_RS02815 ^@ http://purl.uniprot.org/uniprot/A8A9X4 ^@ Similarity ^@ Belongs to the complex I subunit 3 family. http://togogenome.org/gene/453591:IGNI_RS01005 ^@ http://purl.uniprot.org/uniprot/A8A8X4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS07265 ^@ http://purl.uniprot.org/uniprot/A8ACC4 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/453591:IGNI_RS01790 ^@ http://purl.uniprot.org/uniprot/A8A9C7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/453591:IGNI_RS07315 ^@ http://purl.uniprot.org/uniprot/A8ACD2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L24e, part of which may contact the 16S rRNA in 2 intersubunit bridges. http://togogenome.org/gene/453591:IGNI_RS00315 ^@ http://purl.uniprot.org/uniprot/A8A8J0 ^@ Similarity ^@ Belongs to the FKBP-type PPIase family. http://togogenome.org/gene/453591:IGNI_RS04565 ^@ http://purl.uniprot.org/uniprot/A8AAW5 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/453591:IGNI_RS01310 ^@ http://purl.uniprot.org/uniprot/A8A935 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic release factor 1 family. Pelota subfamily.|||Cytoplasm|||May function in recognizing stalled ribosomes, interact with stem-loop structures in stalled mRNA molecules, and effect endonucleolytic cleavage of the mRNA. May play a role in the release non-functional ribosomes and degradation of damaged mRNAs. Has endoribonuclease activity.|||Monomer.|||The N-terminal domain has the RNA-binding Sm fold. It harbors the endoribonuclease activity. http://togogenome.org/gene/453591:IGNI_RS05900 ^@ http://purl.uniprot.org/uniprot/A8ABM2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS07105 ^@ http://purl.uniprot.org/uniprot/A8AC96 ^@ Function|||Similarity ^@ Belongs to the TFIIB family.|||Stabilizes TBP binding to an archaeal box-A promoter. Also responsible for recruiting RNA polymerase II to the pre-initiation complex (DNA-TBP-TFIIB). http://togogenome.org/gene/453591:IGNI_RS05675 ^@ http://purl.uniprot.org/uniprot/A8ABH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family. MTAP subfamily.|||Catalyzes the reversible phosphorylation of S-methyl-5'-thioadenosine (MTA) to adenine and 5-methylthioribose-1-phosphate. Involved in the breakdown of MTA, a major by-product of polyamine biosynthesis. Responsible for the first step in the methionine salvage pathway after MTA has been generated from S-adenosylmethionine. Has broad substrate specificity with 6-aminopurine nucleosides as preferred substrates.|||Homohexamer. Dimer of a homotrimer. http://togogenome.org/gene/453591:IGNI_RS07220 ^@ http://purl.uniprot.org/uniprot/A8ACB5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses ammonia as a nitrogen source.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS03545 ^@ http://purl.uniprot.org/uniprot/A8AAB4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/453591:IGNI_RS03500 ^@ http://purl.uniprot.org/uniprot/A8AAA4 ^@ Similarity ^@ Belongs to the carbamoyltransferase HypF family. http://togogenome.org/gene/453591:IGNI_RS05200 ^@ http://purl.uniprot.org/uniprot/A8AB87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS00805 ^@ http://purl.uniprot.org/uniprot/A8A8T7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/453591:IGNI_RS03530 ^@ http://purl.uniprot.org/uniprot/A8AAB0 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/453591:IGNI_RS03790 ^@ http://purl.uniprot.org/uniprot/A8AAG3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP. http://togogenome.org/gene/453591:IGNI_RS00385 ^@ http://purl.uniprot.org/uniprot/A8A8K2 ^@ Similarity ^@ Belongs to the NOP5/NOP56 family. http://togogenome.org/gene/453591:IGNI_RS06690 ^@ http://purl.uniprot.org/uniprot/A8AC22 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/453591:IGNI_RS01480 ^@ http://purl.uniprot.org/uniprot/A8A968 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL31 family. http://togogenome.org/gene/453591:IGNI_RS01190 ^@ http://purl.uniprot.org/uniprot/A8A911 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. 7-carboxy-7-deazaguanine synthase family.|||Binds 1 S-adenosyl-L-methionine per subunit.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the complex heterocyclic radical-mediated conversion of 6-carboxy-5,6,7,8-tetrahydropterin (CPH4) to 7-carboxy-7-deazaguanine (CDG), a step common to the biosynthetic pathways of all 7-deazapurine-containing compounds.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS02745 ^@ http://purl.uniprot.org/uniprot/A8A9W1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/453591:IGNI_RS05035 ^@ http://purl.uniprot.org/uniprot/A8AB56 ^@ Similarity ^@ Belongs to the snRNP Sm proteins family. http://togogenome.org/gene/453591:IGNI_RS06275 ^@ http://purl.uniprot.org/uniprot/A8ABU1 ^@ Similarity ^@ Belongs to the UPF0166 family. http://togogenome.org/gene/453591:IGNI_RS03290 ^@ http://purl.uniprot.org/uniprot/A8AA61 ^@ Function|||Similarity ^@ Belongs to the deoxyhypusine synthase family.|||Catalyzes the NAD-dependent oxidative cleavage of spermidine and the subsequent transfer of the butylamine moiety of spermidine to the epsilon-amino group of a specific lysine residue of the eIF-5A precursor protein to form the intermediate deoxyhypusine residue. http://togogenome.org/gene/453591:IGNI_RS05055 ^@ http://purl.uniprot.org/uniprot/A8AB60 ^@ Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. http://togogenome.org/gene/453591:IGNI_RS06620 ^@ http://purl.uniprot.org/uniprot/A8AC11 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. Hel308 subfamily.|||DNA-dependent ATPase and 3'-5' DNA helicase that may be involved in repair of stalled replication forks.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS03770 ^@ http://purl.uniprot.org/uniprot/A8AAF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS04265 ^@ http://purl.uniprot.org/uniprot/A8AAQ5 ^@ Function|||Similarity ^@ Belongs to the HypA/HybF family.|||Involved in the maturation of [NiFe] hydrogenases. Required for nickel insertion into the metal center of the hydrogenase. http://togogenome.org/gene/453591:IGNI_RS04925 ^@ http://purl.uniprot.org/uniprot/A8AB36 ^@ Similarity ^@ Belongs to the UPF0201 family. http://togogenome.org/gene/453591:IGNI_RS05085 ^@ http://purl.uniprot.org/uniprot/A8AB67 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/453591:IGNI_RS06445 ^@ http://purl.uniprot.org/uniprot/A8ABX6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/453591:IGNI_RS00085 ^@ http://purl.uniprot.org/uniprot/A8A8E5 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/453591:IGNI_RS04330 ^@ http://purl.uniprot.org/uniprot/A8AAR8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL40 family. http://togogenome.org/gene/453591:IGNI_RS06090 ^@ http://purl.uniprot.org/uniprot/A8ABQ9 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Trm1 family.|||Dimethylates a single guanine residue at position 26 of a number of tRNAs using S-adenosyl-L-methionine as donor of the methyl groups. http://togogenome.org/gene/453591:IGNI_RS05790 ^@ http://purl.uniprot.org/uniprot/A8ABK0 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/453591:IGNI_RS05180 ^@ http://purl.uniprot.org/uniprot/A8AB83 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RecA-like protein family.|||Involved in DNA repair and in homologous recombination. Binds and assemble on single-stranded DNA to form a nucleoprotein filament. Hydrolyzes ATP in a ssDNA-dependent manner and promotes DNA strand exchange between homologous DNA molecules. http://togogenome.org/gene/453591:IGNI_RS06625 ^@ http://purl.uniprot.org/uniprot/A8AC12 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/453591:IGNI_RS05140 ^@ http://purl.uniprot.org/uniprot/A8AB76 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL16 family. http://togogenome.org/gene/453591:IGNI_RS06455 ^@ http://purl.uniprot.org/uniprot/A8ABX8 ^@ Similarity ^@ Belongs to the UPF0173 family. http://togogenome.org/gene/453591:IGNI_RS05575 ^@ http://purl.uniprot.org/uniprot/A8ABF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/453591:IGNI_RS01505 ^@ http://purl.uniprot.org/uniprot/A8A972 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the methyltransferase superfamily. TrmY family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically catalyzes the N1-methylation of pseudouridine at position 54 (Psi54) in tRNAs. http://togogenome.org/gene/453591:IGNI_RS04475 ^@ http://purl.uniprot.org/uniprot/A8AAU7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the QueC family.|||Binds 1 zinc ion per subunit.|||Catalyzes the ATP-dependent conversion of 7-carboxy-7-deazaguanine (CDG) to 7-cyano-7-deazaguanine (preQ(0)). http://togogenome.org/gene/453591:IGNI_RS04240 ^@ http://purl.uniprot.org/uniprot/A8AAQ2 ^@ Similarity ^@ Belongs to the BtpA family. http://togogenome.org/gene/453591:IGNI_RS00355 ^@ http://purl.uniprot.org/uniprot/A8A8J7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS03640 ^@ http://purl.uniprot.org/uniprot/A8AAD3 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/453591:IGNI_RS04870 ^@ http://purl.uniprot.org/uniprot/A8AB25 ^@ Similarity ^@ Belongs to the SAM hydrolase / SAM-dependent halogenase family. http://togogenome.org/gene/453591:IGNI_RS03800 ^@ http://purl.uniprot.org/uniprot/A8AAG5 ^@ Similarity ^@ Belongs to the HerA family. http://togogenome.org/gene/453591:IGNI_RS01025 ^@ http://purl.uniprot.org/uniprot/A8A8X8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS00420 ^@ http://purl.uniprot.org/uniprot/A8A8K9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln). The GatDE system is specific for glutamate and does not act on aspartate.|||Belongs to the GatB/GatE family. GatE subfamily.|||Heterodimer of GatD and GatE. http://togogenome.org/gene/453591:IGNI_RS01425 ^@ http://purl.uniprot.org/uniprot/A8A958 ^@ Similarity ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily. http://togogenome.org/gene/453591:IGNI_RS03535 ^@ http://purl.uniprot.org/uniprot/A8AAB2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase proteolipid subunit family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/453591:IGNI_RS01875 ^@ http://purl.uniprot.org/uniprot/A8A9E3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 3 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro).|||Consists of three domains: the N-terminal catalytic domain, the anticodon-binding domain and the C-terminal extension.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS06470 ^@ http://purl.uniprot.org/uniprot/A8ABY1 ^@ Subunit ^@ Heterotetramer of one alpha, one beta, one delta and one gamma chain. http://togogenome.org/gene/453591:IGNI_RS07490 ^@ http://purl.uniprot.org/uniprot/A8ACG6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS01460 ^@ http://purl.uniprot.org/uniprot/A8A964 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS04010 ^@ http://purl.uniprot.org/uniprot/A8AAK8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/453591:IGNI_RS00465 ^@ http://purl.uniprot.org/uniprot/A8A8L8 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/453591:IGNI_RS02975 ^@ http://purl.uniprot.org/uniprot/A8AA02 ^@ Similarity ^@ Belongs to the HupF/HypC family. http://togogenome.org/gene/453591:IGNI_RS05315 ^@ http://purl.uniprot.org/uniprot/A8ABA9 ^@ Similarity ^@ Belongs to the AOR/FOR family. http://togogenome.org/gene/453591:IGNI_RS05800 ^@ http://purl.uniprot.org/uniprot/A8ABK2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ A structure-specific endonuclease that resolves Holliday junction (HJ) intermediates during genetic recombination. Cleaves 4-way DNA junctions introducing paired nicks in opposing strands, leaving a 5'-terminal phosphate and a 3'-terminal hydroxyl group that are ligated to produce recombinant products.|||Belongs to the Holliday junction resolvase Hjc family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS02410 ^@ http://purl.uniprot.org/uniprot/A8A9P6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/453591:IGNI_RS01195 ^@ http://purl.uniprot.org/uniprot/A8A912 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Cytoplasm|||Multifunctional RNA-binding protein that recognizes the K-turn motif in ribosomal RNA, the RNA component of RNase P, box H/ACA, box C/D and box C'/D' sRNAs.|||Part of the 50S ribosomal subunit. Probably part of the RNase P complex. http://togogenome.org/gene/453591:IGNI_RS06560 ^@ http://purl.uniprot.org/uniprot/A8ABZ9 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS03960 ^@ http://purl.uniprot.org/uniprot/A8AAJ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SRP19 family.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds directly to 7S RNA and mediates binding of the 54 kDa subunit of the SRP.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/453591:IGNI_RS01280 ^@ http://purl.uniprot.org/uniprot/A8A929 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Part of the 30S ribosomal subunit.|||With S4 and S5 plays an important role in translational accuracy. Located at the interface of the 30S and 50S subunits. http://togogenome.org/gene/453591:IGNI_RS03310 ^@ http://purl.uniprot.org/uniprot/A8AA65 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/453591:IGNI_RS04395 ^@ http://purl.uniprot.org/uniprot/A8AAT2 ^@ Similarity ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family. http://togogenome.org/gene/453591:IGNI_RS01395 ^@ http://purl.uniprot.org/uniprot/A8A952 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS31 family.|||Binds 1 zinc ion per subunit.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS07230 ^@ http://purl.uniprot.org/uniprot/A8ACB7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/453591:IGNI_RS04525 ^@ http://purl.uniprot.org/uniprot/A8AAV7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family.|||Catalyzes the methyl esterification of L-isoaspartyl residues in peptides and proteins that result from spontaneous decomposition of normal L-aspartyl and L-asparaginyl residues. It plays a role in the repair and/or degradation of damaged proteins.|||Cytoplasm http://togogenome.org/gene/453591:IGNI_RS05375 ^@ http://purl.uniprot.org/uniprot/A8ABC0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. Archaeal SRP consists of a 7S RNA molecule of 300 nucleotides and two protein subunits: SRP54 and SRP19. http://togogenome.org/gene/453591:IGNI_RS04950 ^@ http://purl.uniprot.org/uniprot/A8AB41 ^@ Similarity ^@ Belongs to the RuvB family. http://togogenome.org/gene/453591:IGNI_RS07485 ^@ http://purl.uniprot.org/uniprot/A8ACG5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta-RFA-P synthase family.|||Catalyzes the condensation of 4-aminobenzoate (pABA) with 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to produce beta-ribofuranosylaminobenzene 5'-phosphate (beta-RFA-P).|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS02345 ^@ http://purl.uniprot.org/uniprot/A8A9N3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the archaeal phosphopantothenate synthetase family.|||Catalyzes the condensation of (R)-4-phosphopantoate and beta-alanine to 4'-phosphopantothenate in the CoA biosynthesis pathway.|||Homodimer. http://togogenome.org/gene/453591:IGNI_RS00490 ^@ http://purl.uniprot.org/uniprot/A8A8M4 ^@ Function|||Similarity ^@ Belongs to the HARP family.|||RNA-free RNase P that catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. http://togogenome.org/gene/453591:IGNI_RS03955 ^@ http://purl.uniprot.org/uniprot/A8AAJ7 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/453591:IGNI_RS03240 ^@ http://purl.uniprot.org/uniprot/A8AA52 ^@ Similarity ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family. http://togogenome.org/gene/453591:IGNI_RS04790 ^@ http://purl.uniprot.org/uniprot/A8AB09 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 2 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD.