http://togogenome.org/gene/523794:LEBU_RS01790 ^@ http://purl.uniprot.org/uniprot/C7NE75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS11215 ^@ http://purl.uniprot.org/uniprot/C7NDX9 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523794:LEBU_RS10670 ^@ http://purl.uniprot.org/uniprot/C7NDB9 ^@ Similarity ^@ Belongs to the UPF0758 family. http://togogenome.org/gene/523794:LEBU_RS03625 ^@ http://purl.uniprot.org/uniprot/C7N8Z6 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS01785 ^@ http://purl.uniprot.org/uniprot/C7NE74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS02525 ^@ http://purl.uniprot.org/uniprot/C7NEP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-C family. PolC subfamily.|||Cytoplasm|||Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. http://togogenome.org/gene/523794:LEBU_RS06185 ^@ http://purl.uniprot.org/uniprot/C7NAF7 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/523794:LEBU_RS10810 ^@ http://purl.uniprot.org/uniprot/C7NDQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/523794:LEBU_RS08875 ^@ http://purl.uniprot.org/uniprot/C7NBY4 ^@ Activity Regulation|||Biotechnology|||Cofactor|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas13a family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements (spacer sequences) and target invading nucleic acids. Unlike many single-component effectors, this CRISPR-Cas system targets RNA (PubMed:27669025). CRISPR clusters are transcribed from pre-CRISPR RNA (crRNA) and processed into crRNA by this protein (PubMed:27669025, PubMed:28475872, PubMed:28757251). pre-crRNA processing yields a 5'-OH and probably a 2',3'-cyclic phosphate (PubMed:27669025). Also cleaves pre-crRNA from several other type VI-A CRISPR systems (PubMed:28475872). Cleaves linear target ssRNA in a crRNA-dependent fashion, preferentially before U residues (PubMed:27669025, PubMed:28475872). Cleavage of target ssRNA is about 80-fold faster than pre-crRNA processing and uses a different active site (PubMed:27669025). Binding a viable target RNA target activates this protein for non-specific RNA degradation in vitro (called collateral RNA degradation) (PubMed:27669025, PubMed:28475872, PubMed:28757251). Activation occurs with 10 fM target RNA (PubMed:28475872). crRNA maturation is not essential for activation of RNA degradation, but lack of mature crRNA (due to mutagenesis) decreases activation levels (PubMed:28475872). This system has a 3' protospacer flanking site in the target RNA (PFS), which is C and unavailable to base pair with crRNA (PFS is equivalent to PAM, the protospacer adjacent motif) (PubMed:28757251).|||Can be used to detect low levels of cellular transcripts, which might be useful to create sequence-specific RNA-targeting tools (PubMed:27669025).|||Crystals show the 3'-end of target RNA interacting with an adjacent protein molecule, and mutagenesis of those amino acid residues decreases target RNA cleavage, but it is not clear if this is physiological (PubMed:28757251).|||Part of a type VI-A uridine-prefering CRISPR-Cas system.|||Pre-crRNA processing is metal independent, while crRNA-guided target RNA cleavage is dependent on divalent metal (i.e. inhibited by EDTA) (PubMed:27669025).|||Target RNA acts as an activator for non-specific ssRNA cleavage; the target RNA and complementary crRNA must both be at least 20 nucleotides long to activate the HEPN-like catalytic pocket for RNase activity (PubMed:28757251).|||The X-ray structure in complex with crRNA and target RNA shows a crRNA-recognition lobe (REC, residues 1-360) which anchors the crRNA repeat and a nuclease lobe (NUC, residues 361-1159) which binds the spacer crRNA-target RNA duplex and cleaves target RNA (PubMed:28757251). The target ssRNase active sites are within the 2 HEPN-like folds, which interact in vivo to form the functional active site (PubMed:26593719, PubMed:28757251). The N-terminal region and HEPN-like fold 2 play a role in pre-crRNA processing (PubMed:28475872). Binding of target RNA to the Cas13a-crRNA complex induces conformational changes that include bringing the 2 HEPN-like domains together to form the target cleavage active site, widening the channel that binds the crRNA-target RNA duplex, facilitating contact between the NUC lobe and the RNA duplex, and altering the conformation of the crRNA (PubMed:28757251). http://togogenome.org/gene/523794:LEBU_RS06540 ^@ http://purl.uniprot.org/uniprot/C7NAM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09100 ^@ http://purl.uniprot.org/uniprot/C7NC27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccA family.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. First, biotin carboxylase catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the carboxyltransferase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS10875 ^@ http://purl.uniprot.org/uniprot/C7NDS1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523794:LEBU_RS06785 ^@ http://purl.uniprot.org/uniprot/C7NAS8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/523794:LEBU_RS09560 ^@ http://purl.uniprot.org/uniprot/C7NCE6 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/523794:LEBU_RS03275 ^@ http://purl.uniprot.org/uniprot/C7N8S4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/523794:LEBU_RS00380 ^@ http://purl.uniprot.org/uniprot/C7NCU0 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/523794:LEBU_RS00850 ^@ http://purl.uniprot.org/uniprot/C7NDD3 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/523794:LEBU_RS02130 ^@ http://purl.uniprot.org/uniprot/C7NEH4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Nth/MutY family.|||Binds 1 [4Fe-4S] cluster.|||DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'-phosphate. http://togogenome.org/gene/523794:LEBU_RS03865 ^@ http://purl.uniprot.org/uniprot/C7N944 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the PyrI family.|||Binds 1 zinc ion per subunit.|||Contains catalytic and regulatory chains.|||Involved in allosteric regulation of aspartate carbamoyltransferase. http://togogenome.org/gene/523794:LEBU_RS08240 ^@ http://purl.uniprot.org/uniprot/C7NBL0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the shikimate dehydrogenase family.|||Homodimer.|||Involved in the biosynthesis of the chorismate, which leads to the biosynthesis of aromatic amino acids. Catalyzes the reversible NADPH linked reduction of 3-dehydroshikimate (DHSA) to yield shikimate (SA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09045 ^@ http://purl.uniprot.org/uniprot/C7NC16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS08440 ^@ http://purl.uniprot.org/uniprot/C7NBP9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS11470 ^@ http://purl.uniprot.org/uniprot/C7NEF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03795 ^@ http://purl.uniprot.org/uniprot/C7N930 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS03215 ^@ http://purl.uniprot.org/uniprot/C7N8R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS09845 ^@ http://purl.uniprot.org/uniprot/C7NCK3 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/523794:LEBU_RS07880 ^@ http://purl.uniprot.org/uniprot/C7NBD9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/523794:LEBU_RS00625 ^@ http://purl.uniprot.org/uniprot/C7NCY2 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M3 family.|||Binds 1 zinc ion. http://togogenome.org/gene/523794:LEBU_RS01740 ^@ http://purl.uniprot.org/uniprot/C7NE65 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS09640 ^@ http://purl.uniprot.org/uniprot/C7NCG2 ^@ Similarity ^@ Belongs to the peptidase M29 family. http://togogenome.org/gene/523794:LEBU_RS07445 ^@ http://purl.uniprot.org/uniprot/C7NB51 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/523794:LEBU_RS07175 ^@ http://purl.uniprot.org/uniprot/C7NB00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/523794:LEBU_RS05285 ^@ http://purl.uniprot.org/uniprot/C7N9X9 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/523794:LEBU_RS10490 ^@ http://purl.uniprot.org/uniprot/C7ND85 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PEPCase type 1 family.|||Forms oxaloacetate, a four-carbon dicarboxylic acid source for the tricarboxylic acid cycle.|||Homotetramer. http://togogenome.org/gene/523794:LEBU_RS03485 ^@ http://purl.uniprot.org/uniprot/C7N8W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase Y family.|||Cell membrane|||Endoribonuclease that initiates mRNA decay. http://togogenome.org/gene/523794:LEBU_RS00450 ^@ http://purl.uniprot.org/uniprot/C7NCV2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiM family.|||Cell inner membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Membrane|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/523794:LEBU_RS05680 ^@ http://purl.uniprot.org/uniprot/C7NA61 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523794:LEBU_RS05245 ^@ http://purl.uniprot.org/uniprot/C7N9X1 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/523794:LEBU_RS08790 ^@ http://purl.uniprot.org/uniprot/C7NBW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OmpP1/FadL family.|||Cell outer membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS09555 ^@ http://purl.uniprot.org/uniprot/C7NCE5 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family.|||Necessary for normal cell division and for the maintenance of normal septation. http://togogenome.org/gene/523794:LEBU_RS01910 ^@ http://purl.uniprot.org/uniprot/C7NE98 ^@ Similarity ^@ Belongs to the PAPS reductase family. CysD subfamily. http://togogenome.org/gene/523794:LEBU_RS01040 ^@ http://purl.uniprot.org/uniprot/C7NDG1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS02725 ^@ http://purl.uniprot.org/uniprot/C7N8G7 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/523794:LEBU_RS03005 ^@ http://purl.uniprot.org/uniprot/C7N8M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS00150 ^@ http://purl.uniprot.org/uniprot/C7NCC5 ^@ Caution|||Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/523794:LEBU_RS09160 ^@ http://purl.uniprot.org/uniprot/C7NC39 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS03410 ^@ http://purl.uniprot.org/uniprot/C7N8V3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase D family. Cardiolipin synthase subfamily.|||Catalyzes the reversible phosphatidyl group transfer from one phosphatidylglycerol molecule to another to form cardiolipin (CL) (diphosphatidylglycerol) and glycerol.|||Cell inner membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS11195 ^@ http://purl.uniprot.org/uniprot/C7NDX6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08050 ^@ http://purl.uniprot.org/uniprot/C7NBH3 ^@ Similarity ^@ Belongs to the UPF0045 family. http://togogenome.org/gene/523794:LEBU_RS08705 ^@ http://purl.uniprot.org/uniprot/C7NBV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BBS4 family.|||Membrane|||centrosome|||cilium membrane http://togogenome.org/gene/523794:LEBU_RS00465 ^@ http://purl.uniprot.org/uniprot/C7NCV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily.|||Cell membrane|||Part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523794:LEBU_RS01590 ^@ http://purl.uniprot.org/uniprot/C7NE35 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/523794:LEBU_RS01570 ^@ http://purl.uniprot.org/uniprot/C7NE31 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class B bacterial acid phosphatase family.|||Homotetramer.|||Periplasm http://togogenome.org/gene/523794:LEBU_RS05505 ^@ http://purl.uniprot.org/uniprot/C7NA26 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/523794:LEBU_RS10655 ^@ http://purl.uniprot.org/uniprot/C7NDB6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPI family.|||Catalyzes the reversible isomerization of glucose-6-phosphate to fructose-6-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03980 ^@ http://purl.uniprot.org/uniprot/C7N967 ^@ Similarity ^@ Belongs to the PspA/IM30 family. http://togogenome.org/gene/523794:LEBU_RS06425 ^@ http://purl.uniprot.org/uniprot/C7NAK7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A probable RNA chaperone. Forms a complex with KhpB which binds to cellular RNA and controls its expression. Plays a role in peptidoglycan (PG) homeostasis and cell length regulation.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm|||Forms a complex with KhpB. http://togogenome.org/gene/523794:LEBU_RS11380 ^@ http://purl.uniprot.org/uniprot/C7NED4 ^@ Function|||Similarity ^@ Belongs to the SpoVG family.|||Could be involved in septation. http://togogenome.org/gene/523794:LEBU_RS09860 ^@ http://purl.uniprot.org/uniprot/C7NCK6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS06910 ^@ http://purl.uniprot.org/uniprot/C7NAV4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase HII family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/523794:LEBU_RS02570 ^@ http://purl.uniprot.org/uniprot/C7NEQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vitamin uptake transporter (VUT/ECF) (TC 2.A.88) family. Q precursor transporter subfamily.|||Cell inner membrane|||Involved in the import of queuosine (Q) precursors, required for Q precursor salvage. http://togogenome.org/gene/523794:LEBU_RS06740 ^@ http://purl.uniprot.org/uniprot/C7NAR9 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS02190 ^@ http://purl.uniprot.org/uniprot/C7NEI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS01955 ^@ http://purl.uniprot.org/uniprot/C7NEA7 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 57 family. http://togogenome.org/gene/523794:LEBU_RS03940 ^@ http://purl.uniprot.org/uniprot/C7N959 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/523794:LEBU_RS07425 ^@ http://purl.uniprot.org/uniprot/C7NB47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS10010 ^@ http://purl.uniprot.org/uniprot/C7NCN5 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS04130 ^@ http://purl.uniprot.org/uniprot/C7N997 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. NspC subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08965 ^@ http://purl.uniprot.org/uniprot/C7NBZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the oxidase-dependent Fe transporter (OFeT) (TC 9.A.10.1) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS07720 ^@ http://purl.uniprot.org/uniprot/C7NBA6 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS06805 ^@ http://purl.uniprot.org/uniprot/C7NAT2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/523794:LEBU_RS10495 ^@ http://purl.uniprot.org/uniprot/C7ND86 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DNA mismatch repair MutS family. MutS2 subfamily.|||Endonuclease that is involved in the suppression of homologous recombination and may therefore have a key role in the control of bacterial genetic diversity.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08125 ^@ http://purl.uniprot.org/uniprot/C7NBI8 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/523794:LEBU_RS06840 ^@ http://purl.uniprot.org/uniprot/C7NAT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alanine or glycine:cation symporter (AGCS) (TC 2.A.25) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS02415 ^@ http://purl.uniprot.org/uniprot/C7NEM5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09235 ^@ http://purl.uniprot.org/uniprot/C7NC48 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/523794:LEBU_RS07315 ^@ http://purl.uniprot.org/uniprot/C7NB27 ^@ Function ^@ Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system. http://togogenome.org/gene/523794:LEBU_RS04000 ^@ http://purl.uniprot.org/uniprot/C7N971 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/523794:LEBU_RS09270 ^@ http://purl.uniprot.org/uniprot/C7NC55 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09980 ^@ http://purl.uniprot.org/uniprot/C7NCM9 ^@ Similarity ^@ Belongs to the Fur family. http://togogenome.org/gene/523794:LEBU_RS00930 ^@ http://purl.uniprot.org/uniprot/C7NDE6 ^@ Function|||Similarity ^@ Belongs to the UPF0122 family.|||Might take part in the signal recognition particle (SRP) pathway. This is inferred from the conservation of its genetic proximity to ftsY/ffh. May be a regulatory protein. http://togogenome.org/gene/523794:LEBU_RS03270 ^@ http://purl.uniprot.org/uniprot/C7N8S3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/523794:LEBU_RS03080 ^@ http://purl.uniprot.org/uniprot/C7N8N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS07330 ^@ http://purl.uniprot.org/uniprot/C7NB30 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseA family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/523794:LEBU_RS08315 ^@ http://purl.uniprot.org/uniprot/C7NBM5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/523794:LEBU_RS06525 ^@ http://purl.uniprot.org/uniprot/C7NAM6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/523794:LEBU_RS08245 ^@ http://purl.uniprot.org/uniprot/C7NBL1 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/523794:LEBU_RS09275 ^@ http://purl.uniprot.org/uniprot/C7NC57 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/523794:LEBU_RS07815 ^@ http://purl.uniprot.org/uniprot/C7NBC6 ^@ Similarity ^@ Belongs to the peptidase S66 family. http://togogenome.org/gene/523794:LEBU_RS07165 ^@ http://purl.uniprot.org/uniprot/C7NAZ8 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/523794:LEBU_RS05865 ^@ http://purl.uniprot.org/uniprot/C7NA96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS05030 ^@ http://purl.uniprot.org/uniprot/C7N9S8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0702 family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS06485 ^@ http://purl.uniprot.org/uniprot/C7NAL8 ^@ Function|||Induction|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short-lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner.|||Belongs to the peptidase S16 family.|||By heat shock.|||Cytoplasm|||Homohexamer. Organized in a ring with a central cavity. http://togogenome.org/gene/523794:LEBU_RS05200 ^@ http://purl.uniprot.org/uniprot/C7N9W2 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/523794:LEBU_RS01635 ^@ http://purl.uniprot.org/uniprot/C7NE44 ^@ Caution|||Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Belongs to the MsrB Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS11525 ^@ http://purl.uniprot.org/uniprot/C7NEG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/523794:LEBU_RS03075 ^@ http://purl.uniprot.org/uniprot/C7N8N4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03500 ^@ http://purl.uniprot.org/uniprot/C7N8X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS07745 ^@ http://purl.uniprot.org/uniprot/C7NBB1 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/523794:LEBU_RS02985 ^@ http://purl.uniprot.org/uniprot/C7N8L7 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per trimer. http://togogenome.org/gene/523794:LEBU_RS03605 ^@ http://purl.uniprot.org/uniprot/C7N8Z2 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily. http://togogenome.org/gene/523794:LEBU_RS10515 ^@ http://purl.uniprot.org/uniprot/C7ND90 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS01270 ^@ http://purl.uniprot.org/uniprot/C7NDK9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/523794:LEBU_RS08990 ^@ http://purl.uniprot.org/uniprot/C7NC04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS00640 ^@ http://purl.uniprot.org/uniprot/C7NCY5 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/523794:LEBU_RS04275 ^@ http://purl.uniprot.org/uniprot/C7N9C6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. http://togogenome.org/gene/523794:LEBU_RS11275 ^@ http://purl.uniprot.org/uniprot/C7NDZ1 ^@ Similarity ^@ Belongs to the FtsK/SpoIIIE/SftA family. http://togogenome.org/gene/523794:LEBU_RS01080 ^@ http://purl.uniprot.org/uniprot/C7NDG9 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS02220 ^@ http://purl.uniprot.org/uniprot/C7NEJ2 ^@ Similarity ^@ Belongs to the peptidase S49 family. http://togogenome.org/gene/523794:LEBU_RS03060 ^@ http://purl.uniprot.org/uniprot/C7N8N1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/523794:LEBU_RS05560 ^@ http://purl.uniprot.org/uniprot/C7NA38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the uridine kinase family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS04005 ^@ http://purl.uniprot.org/uniprot/C7N972 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the CRISPR-associated exonuclease Cas4 family.|||CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA).|||Mg(2+) or Mn(2+) required for ssDNA cleavage activity. http://togogenome.org/gene/523794:LEBU_RS01110 ^@ http://purl.uniprot.org/uniprot/C7NDH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell inner membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/523794:LEBU_RS03540 ^@ http://purl.uniprot.org/uniprot/C7N8X9 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/523794:LEBU_RS02785 ^@ http://purl.uniprot.org/uniprot/C7N8H8 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/523794:LEBU_RS10980 ^@ http://purl.uniprot.org/uniprot/C7NDU2 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/523794:LEBU_RS03505 ^@ http://purl.uniprot.org/uniprot/C7N8X2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/523794:LEBU_RS02605 ^@ http://purl.uniprot.org/uniprot/C7NER3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/523794:LEBU_RS06305 ^@ http://purl.uniprot.org/uniprot/C7NAI3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thioester dehydratase family. FabZ subfamily.|||Cytoplasm|||Involved in unsaturated fatty acids biosynthesis. Catalyzes the dehydration of short chain beta-hydroxyacyl-ACPs and long chain saturated and unsaturated beta-hydroxyacyl-ACPs. http://togogenome.org/gene/523794:LEBU_RS09575 ^@ http://purl.uniprot.org/uniprot/C7NCE9 ^@ Function|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer of biotin carboxyl carrier protein, biotin carboxylase and the two subunits of carboxyl transferase in a 2:2 complex.|||This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/523794:LEBU_RS01210 ^@ http://purl.uniprot.org/uniprot/C7NDJ7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/523794:LEBU_RS01235 ^@ http://purl.uniprot.org/uniprot/C7NDK2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/523794:LEBU_RS06415 ^@ http://purl.uniprot.org/uniprot/C7NAK5 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/523794:LEBU_RS08255 ^@ http://purl.uniprot.org/uniprot/C7NBL3 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS09135 ^@ http://purl.uniprot.org/uniprot/C7NC34 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS04020 ^@ http://purl.uniprot.org/uniprot/C7N975 ^@ Function ^@ CRISPR (clustered regularly interspaced short palindromic repeat) is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). http://togogenome.org/gene/523794:LEBU_RS05880 ^@ http://purl.uniprot.org/uniprot/C7NA99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS06010 ^@ http://purl.uniprot.org/uniprot/C7NAC4 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/523794:LEBU_RS01560 ^@ http://purl.uniprot.org/uniprot/C7NE29 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08970 ^@ http://purl.uniprot.org/uniprot/C7NC00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell inner membrane|||Forms a complex with TatA.|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. http://togogenome.org/gene/523794:LEBU_RS01840 ^@ http://purl.uniprot.org/uniprot/C7NE85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523794:LEBU_RS06865 ^@ http://purl.uniprot.org/uniprot/C7NAU4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/523794:LEBU_RS02475 ^@ http://purl.uniprot.org/uniprot/C7NEN7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS07370 ^@ http://purl.uniprot.org/uniprot/C7NB36 ^@ Similarity ^@ Belongs to the glycosyl hydrolase. http://togogenome.org/gene/523794:LEBU_RS07465 ^@ http://purl.uniprot.org/uniprot/C7NB55 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/523794:LEBU_RS00315 ^@ http://purl.uniprot.org/uniprot/C7NCS7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial microcompartment|||Belongs to the EutC family.|||Binds between the large and small subunits.|||Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of external vitamin B12.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. http://togogenome.org/gene/523794:LEBU_RS06020 ^@ http://purl.uniprot.org/uniprot/C7NAC6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Belongs to the NnrE/AIBP family.|||Bifunctional enzyme that catalyzes the epimerization of the S- and R-forms of NAD(P)HX and the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. This allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Binds 1 potassium ion per subunit.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Catalyzes the epimerization of the S- and R-forms of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration. This is a prerequisite for the S-specific NAD(P)H-hydrate dehydratase to allow the repair of both epimers of NAD(P)HX.|||Homotetramer.|||In the C-terminal section; belongs to the NnrD/CARKD family.|||In the N-terminal section; belongs to the NnrE/AIBP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09885 ^@ http://purl.uniprot.org/uniprot/C7NCL0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS07280 ^@ http://purl.uniprot.org/uniprot/C7NB20 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS02320 ^@ http://purl.uniprot.org/uniprot/C7NEK7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homodimer.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. The enzyme II ManXYZ PTS system is involved in mannose transport. http://togogenome.org/gene/523794:LEBU_RS06795 ^@ http://purl.uniprot.org/uniprot/C7NAT0 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/523794:LEBU_RS05780 ^@ http://purl.uniprot.org/uniprot/C7NA80 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/523794:LEBU_RS07735 ^@ http://purl.uniprot.org/uniprot/C7NBA9 ^@ Similarity ^@ Belongs to the Cob(I)alamin adenosyltransferase family. http://togogenome.org/gene/523794:LEBU_RS09210 ^@ http://purl.uniprot.org/uniprot/C7NC43 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/523794:LEBU_RS01195 ^@ http://purl.uniprot.org/uniprot/C7NDJ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS11510 ^@ http://purl.uniprot.org/uniprot/C7NEG0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. TrmE GTPase family.|||Binds 1 potassium ion per subunit.|||Cytoplasm|||Exhibits a very high intrinsic GTPase hydrolysis rate. Involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34.|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS04060 ^@ http://purl.uniprot.org/uniprot/C7N983 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09715 ^@ http://purl.uniprot.org/uniprot/C7NCH7 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/523794:LEBU_RS02110 ^@ http://purl.uniprot.org/uniprot/C7NEH0 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 1 subfamily.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05755 ^@ http://purl.uniprot.org/uniprot/C7NA75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS04095 ^@ http://purl.uniprot.org/uniprot/C7N990 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/523794:LEBU_RS07045 ^@ http://purl.uniprot.org/uniprot/C7NAX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS05065 ^@ http://purl.uniprot.org/uniprot/C7N9T5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/523794:LEBU_RS00385 ^@ http://purl.uniprot.org/uniprot/C7NCU1 ^@ Similarity ^@ Belongs to the EutP/PduV family. http://togogenome.org/gene/523794:LEBU_RS08400 ^@ http://purl.uniprot.org/uniprot/C7NBP1 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/523794:LEBU_RS07120 ^@ http://purl.uniprot.org/uniprot/C7NAY9 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/523794:LEBU_RS11000 ^@ http://purl.uniprot.org/uniprot/C7NDU5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/523794:LEBU_RS08150 ^@ http://purl.uniprot.org/uniprot/C7NBJ3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/523794:LEBU_RS07285 ^@ http://purl.uniprot.org/uniprot/C7NB21 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523794:LEBU_RS00025 ^@ http://purl.uniprot.org/uniprot/C7NC99 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/523794:LEBU_RS11185 ^@ http://purl.uniprot.org/uniprot/C7NDX4 ^@ Similarity ^@ Belongs to the low molecular weight phosphotyrosine protein phosphatase family. http://togogenome.org/gene/523794:LEBU_RS07310 ^@ http://purl.uniprot.org/uniprot/C7NB26 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09495 ^@ http://purl.uniprot.org/uniprot/C7NCD5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell inner membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS07985 ^@ http://purl.uniprot.org/uniprot/C7NBG0 ^@ Function|||Similarity ^@ Belongs to the KptA/TPT1 family.|||Removes the 2'-phosphate from RNA via an intermediate in which the phosphate is ADP-ribosylated by NAD followed by a presumed transesterification to release the RNA and generate ADP-ribose 1''-2''-cyclic phosphate (APPR>P). May function as an ADP-ribosylase. http://togogenome.org/gene/523794:LEBU_RS03715 ^@ http://purl.uniprot.org/uniprot/C7N914 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Homohexamer.|||In the C-terminal section; belongs to the peptidase M41 family.|||In the central section; belongs to the AAA ATPase family. http://togogenome.org/gene/523794:LEBU_RS07400 ^@ http://purl.uniprot.org/uniprot/C7NB42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. GalK subfamily.|||Catalyzes the transfer of the gamma-phosphate of ATP to D-galactose to form alpha-D-galactose-1-phosphate (Gal-1-P).|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS08820 ^@ http://purl.uniprot.org/uniprot/C7NBX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS01035 ^@ http://purl.uniprot.org/uniprot/C7NDG0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell inner membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS01190 ^@ http://purl.uniprot.org/uniprot/C7NDJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/523794:LEBU_RS01095 ^@ http://purl.uniprot.org/uniprot/C7NDH2 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS01245 ^@ http://purl.uniprot.org/uniprot/C7NDK4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS02455 ^@ http://purl.uniprot.org/uniprot/C7NEN3 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/523794:LEBU_RS09395 ^@ http://purl.uniprot.org/uniprot/C7NC81 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/523794:LEBU_RS11535 ^@ http://purl.uniprot.org/uniprot/C7NEG5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/523794:LEBU_RS11065 ^@ http://purl.uniprot.org/uniprot/C7NDV0 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/523794:LEBU_RS03880 ^@ http://purl.uniprot.org/uniprot/C7N947 ^@ Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate. http://togogenome.org/gene/523794:LEBU_RS02890 ^@ http://purl.uniprot.org/uniprot/C7N8J8 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS04925 ^@ http://purl.uniprot.org/uniprot/C7N9Q6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS03645 ^@ http://purl.uniprot.org/uniprot/C7N900 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ClpA/ClpB family.|||Cytoplasm|||Homohexamer. The oligomerization is ATP-dependent.|||Homohexamer; The oligomerization is ATP-dependent.|||Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. http://togogenome.org/gene/523794:LEBU_RS10570 ^@ http://purl.uniprot.org/uniprot/C7NDA2 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS03875 ^@ http://purl.uniprot.org/uniprot/C7N946 ^@ Function|||Similarity|||Subunit ^@ Belongs to the OMP decarboxylase family. Type 1 subfamily.|||Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP).|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS02765 ^@ http://purl.uniprot.org/uniprot/C7N8H4 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/523794:LEBU_RS10305 ^@ http://purl.uniprot.org/uniprot/C7ND56 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS06470 ^@ http://purl.uniprot.org/uniprot/C7NAL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-3 family.|||Cytoplasm|||IF-3 binds to the 30S ribosomal subunit and shifts the equilibrum between 70S ribosomes and their 50S and 30S subunits in favor of the free subunits, thus enhancing the availability of 30S subunits on which protein synthesis initiation begins.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS07805 ^@ http://purl.uniprot.org/uniprot/C7NBC4 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/523794:LEBU_RS03030 ^@ http://purl.uniprot.org/uniprot/C7N8M5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523794:LEBU_RS06465 ^@ http://purl.uniprot.org/uniprot/C7NAL5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/523794:LEBU_RS05695 ^@ http://purl.uniprot.org/uniprot/C7NA64 ^@ Function|||Similarity ^@ Belongs to the QueH family.|||Catalyzes the conversion of epoxyqueuosine (oQ) to queuosine (Q), which is a hypermodified base found in the wobble positions of tRNA(Asp), tRNA(Asn), tRNA(His) and tRNA(Tyr). http://togogenome.org/gene/523794:LEBU_RS09140 ^@ http://purl.uniprot.org/uniprot/C7NC35 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/523794:LEBU_RS02980 ^@ http://purl.uniprot.org/uniprot/C7N8L6 ^@ Similarity ^@ Belongs to the aldolase LacD family. http://togogenome.org/gene/523794:LEBU_RS09290 ^@ http://purl.uniprot.org/uniprot/C7NC60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the QueA family.|||Cytoplasm|||Monomer.|||Transfers and isomerizes the ribose moiety from AdoMet to the 7-aminomethyl group of 7-deazaguanine (preQ1-tRNA) to give epoxyqueuosine (oQ-tRNA). http://togogenome.org/gene/523794:LEBU_RS09340 ^@ http://purl.uniprot.org/uniprot/C7NC70 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sigma-70 factor family. RpoD/SigA subfamily.|||Cytoplasm|||Interacts transiently with the RNA polymerase catalytic core.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. This sigma factor is the primary sigma factor during exponential growth. http://togogenome.org/gene/523794:LEBU_RS01330 ^@ http://purl.uniprot.org/uniprot/C7NDM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS02735 ^@ http://purl.uniprot.org/uniprot/C7N8G9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09945 ^@ http://purl.uniprot.org/uniprot/C7NCM2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/523794:LEBU_RS03535 ^@ http://purl.uniprot.org/uniprot/C7N8X8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A Gly-cisPro motif from one monomer fits into the active site of the other monomer to allow specific chiral rejection of L-amino acids.|||An aminoacyl-tRNA editing enzyme that deacylates mischarged D-aminoacyl-tRNAs. Also deacylates mischarged glycyl-tRNA(Ala), protecting cells against glycine mischarging by AlaRS. Acts via tRNA-based rather than protein-based catalysis; rejects L-amino acids rather than detecting D-amino acids in the active site. By recycling D-aminoacyl-tRNA to D-amino acids and free tRNA molecules, this enzyme counteracts the toxicity associated with the formation of D-aminoacyl-tRNA entities in vivo and helps enforce protein L-homochirality.|||Belongs to the DTD family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS02970 ^@ http://purl.uniprot.org/uniprot/C7N8L4 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/523794:LEBU_RS06310 ^@ http://purl.uniprot.org/uniprot/C7NAI4 ^@ Function|||Similarity ^@ Belongs to the LpxC family.|||Catalyzes the hydrolysis of UDP-3-O-myristoyl-N-acetylglucosamine to form UDP-3-O-myristoylglucosamine and acetate, the committed step in lipid A biosynthesis. http://togogenome.org/gene/523794:LEBU_RS04950 ^@ http://purl.uniprot.org/uniprot/C7N9R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease M5 family.|||Cytoplasm|||Required for correct processing of both the 5' and 3' ends of 5S rRNA precursor. Cleaves both sides of a double-stranded region yielding mature 5S rRNA in one step. http://togogenome.org/gene/523794:LEBU_RS02315 ^@ http://purl.uniprot.org/uniprot/C7NEK6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08200 ^@ http://purl.uniprot.org/uniprot/C7NBK2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/523794:LEBU_RS02515 ^@ http://purl.uniprot.org/uniprot/C7NEP5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. Csd subfamily. http://togogenome.org/gene/523794:LEBU_RS10435 ^@ http://purl.uniprot.org/uniprot/C7ND77 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of meso-diaminopimelic acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS06490 ^@ http://purl.uniprot.org/uniprot/C7NAL9 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/523794:LEBU_RS09445 ^@ http://purl.uniprot.org/uniprot/C7NC90 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS01395 ^@ http://purl.uniprot.org/uniprot/C7NDM8 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. HypB/HupM subfamily. http://togogenome.org/gene/523794:LEBU_RS09380 ^@ http://purl.uniprot.org/uniprot/C7NC78 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/523794:LEBU_RS09150 ^@ http://purl.uniprot.org/uniprot/C7NC37 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell inner membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/523794:LEBU_RS03175 ^@ http://purl.uniprot.org/uniprot/C7N8Q4 ^@ Similarity ^@ Belongs to the bacterial secretin family. http://togogenome.org/gene/523794:LEBU_RS04940 ^@ http://purl.uniprot.org/uniprot/C7N9Q9 ^@ Similarity ^@ Belongs to the PNP/UDP phosphorylase family. http://togogenome.org/gene/523794:LEBU_RS11205 ^@ http://purl.uniprot.org/uniprot/C7NDX7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the helicase family. PriA subfamily.|||Component of the primosome.|||Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA. http://togogenome.org/gene/523794:LEBU_RS02805 ^@ http://purl.uniprot.org/uniprot/C7N8I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS06165 ^@ http://purl.uniprot.org/uniprot/C7NAF3 ^@ Similarity ^@ Belongs to the folylpolyglutamate synthase family. http://togogenome.org/gene/523794:LEBU_RS10795 ^@ http://purl.uniprot.org/uniprot/C7NDQ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS00010 ^@ http://purl.uniprot.org/uniprot/C7NC96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/523794:LEBU_RS04345 ^@ http://purl.uniprot.org/uniprot/C7N9E0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DNA polymerase type-Y family.|||Binds 2 magnesium ions per subunit.|||Cytoplasm|||Monomer.|||Poorly processive, error-prone DNA polymerase involved in untargeted mutagenesis. Copies undamaged DNA at stalled replication forks, which arise in vivo from mismatched or misaligned primer ends. These misaligned primers can be extended by PolIV. Exhibits no 3'-5' exonuclease (proofreading) activity. May be involved in translesional synthesis, in conjunction with the beta clamp from PolIII. http://togogenome.org/gene/523794:LEBU_RS09965 ^@ http://purl.uniprot.org/uniprot/C7NCM6 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/523794:LEBU_RS00320 ^@ http://purl.uniprot.org/uniprot/C7NCS8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Bacterial microcompartment|||Belongs to the EutB family.|||Binds between the large and small subunits.|||Catalyzes the deamination of various vicinal amino-alcohols to oxo compounds. Allows this organism to utilize ethanolamine as the sole source of nitrogen and carbon in the presence of vitamin B12.|||The basic unit is a heterodimer which dimerizes to form tetramers. The heterotetramers trimerize; 6 large subunits form a core ring with 6 small subunits projecting outwards. http://togogenome.org/gene/523794:LEBU_RS06195 ^@ http://purl.uniprot.org/uniprot/C7NAF9 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/523794:LEBU_RS02900 ^@ http://purl.uniprot.org/uniprot/C7N8K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TonB-dependent receptor family.|||Cell outer membrane http://togogenome.org/gene/523794:LEBU_RS10180 ^@ http://purl.uniprot.org/uniprot/C7ND37 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/523794:LEBU_RS07615 ^@ http://purl.uniprot.org/uniprot/C7NB85 ^@ Similarity ^@ Belongs to the YjdM family. http://togogenome.org/gene/523794:LEBU_RS04260 ^@ http://purl.uniprot.org/uniprot/C7N9C3 ^@ Similarity ^@ Belongs to the aspartokinase family. http://togogenome.org/gene/523794:LEBU_RS08895 ^@ http://purl.uniprot.org/uniprot/C7NBY8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/523794:LEBU_RS01435 ^@ http://purl.uniprot.org/uniprot/C7NDN7 ^@ Similarity ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family. http://togogenome.org/gene/523794:LEBU_RS00400 ^@ http://purl.uniprot.org/uniprot/C7NCU4 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/523794:LEBU_RS09050 ^@ http://purl.uniprot.org/uniprot/C7NC17 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/523794:LEBU_RS04750 ^@ http://purl.uniprot.org/uniprot/C7N9L8 ^@ Similarity ^@ Belongs to the type IA topoisomerase family. http://togogenome.org/gene/523794:LEBU_RS06870 ^@ http://purl.uniprot.org/uniprot/C7NAU5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidine kinase family.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/523794:LEBU_RS09315 ^@ http://purl.uniprot.org/uniprot/C7NC65 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/523794:LEBU_RS00245 ^@ http://purl.uniprot.org/uniprot/C7NCR4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523794:LEBU_RS01310 ^@ http://purl.uniprot.org/uniprot/C7NDL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell inner membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/523794:LEBU_RS01655 ^@ http://purl.uniprot.org/uniprot/C7NE47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS01830 ^@ http://purl.uniprot.org/uniprot/C7NE83 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 1 subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/523794:LEBU_RS00645 ^@ http://purl.uniprot.org/uniprot/C7NCY6 ^@ Function|||Similarity ^@ Belongs to the flavodoxin family.|||Low-potential electron donor to a number of redox enzymes. http://togogenome.org/gene/523794:LEBU_RS02800 ^@ http://purl.uniprot.org/uniprot/C7N8I1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS07460 ^@ http://purl.uniprot.org/uniprot/C7NB54 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523794:LEBU_RS11260 ^@ http://purl.uniprot.org/uniprot/C7NDY8 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/523794:LEBU_RS10925 ^@ http://purl.uniprot.org/uniprot/C7NDT1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ribulose-phosphate 3-epimerase family.|||Binds 1 divalent metal cation per subunit.|||Catalyzes the reversible epimerization of D-ribulose 5-phosphate to D-xylulose 5-phosphate. http://togogenome.org/gene/523794:LEBU_RS08540 ^@ http://purl.uniprot.org/uniprot/C7NBR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/523794:LEBU_RS10310 ^@ http://purl.uniprot.org/uniprot/C7ND57 ^@ Similarity ^@ In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family.|||In the N-terminal section; belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS01695 ^@ http://purl.uniprot.org/uniprot/C7NE55 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNA methyltransferase RsmE family.|||Cytoplasm|||Specifically methylates the N3 position of the uracil ring of uridine 1498 (m3U1498) in 16S rRNA. Acts on the fully assembled 30S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS06235 ^@ http://purl.uniprot.org/uniprot/C7NAG9 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/523794:LEBU_RS07665 ^@ http://purl.uniprot.org/uniprot/C7NB95 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SIS family. GmhA subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.|||Cytoplasm|||The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate. http://togogenome.org/gene/523794:LEBU_RS09590 ^@ http://purl.uniprot.org/uniprot/C7NCF2 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/523794:LEBU_RS06715 ^@ http://purl.uniprot.org/uniprot/C7NAR4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS11110 ^@ http://purl.uniprot.org/uniprot/C7NDV9 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/523794:LEBU_RS02450 ^@ http://purl.uniprot.org/uniprot/C7NEN2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05045 ^@ http://purl.uniprot.org/uniprot/C7N9T1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09910 ^@ http://purl.uniprot.org/uniprot/C7NCL5 ^@ Similarity ^@ Belongs to the UPF0145 family. http://togogenome.org/gene/523794:LEBU_RS05710 ^@ http://purl.uniprot.org/uniprot/C7NA66 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS01225 ^@ http://purl.uniprot.org/uniprot/C7NDK0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/523794:LEBU_RS03695 ^@ http://purl.uniprot.org/uniprot/C7N910 ^@ Similarity ^@ Belongs to the DNA glycosylase MPG family. http://togogenome.org/gene/523794:LEBU_RS08735 ^@ http://purl.uniprot.org/uniprot/C7NBV6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the LuxS family.|||Binds 1 Fe cation per subunit.|||Homodimer.|||Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). http://togogenome.org/gene/523794:LEBU_RS05550 ^@ http://purl.uniprot.org/uniprot/C7NA36 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03610 ^@ http://purl.uniprot.org/uniprot/C7N8Z3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TER reductase family.|||Involved in the final reduction of the elongation cycle of fatty acid synthesis (FAS II). Catalyzes the reduction of a carbon-carbon double bond in an enoyl moiety that is covalently linked to an acyl carrier protein (ACP).|||Monomer. http://togogenome.org/gene/523794:LEBU_RS01770 ^@ http://purl.uniprot.org/uniprot/C7NE71 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/523794:LEBU_RS02425 ^@ http://purl.uniprot.org/uniprot/C7NEM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03255 ^@ http://purl.uniprot.org/uniprot/C7N8S0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell inner membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09410 ^@ http://purl.uniprot.org/uniprot/C7NC83 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/523794:LEBU_RS05365 ^@ http://purl.uniprot.org/uniprot/C7N9Z6 ^@ Similarity ^@ Belongs to the UPF0246 family. http://togogenome.org/gene/523794:LEBU_RS08920 ^@ http://purl.uniprot.org/uniprot/C7NBZ0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/523794:LEBU_RS03205 ^@ http://purl.uniprot.org/uniprot/C7N8R0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS11175 ^@ http://purl.uniprot.org/uniprot/C7NDX2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05965 ^@ http://purl.uniprot.org/uniprot/C7NAB5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell inner membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/523794:LEBU_RS09375 ^@ http://purl.uniprot.org/uniprot/C7NC77 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/523794:LEBU_RS10780 ^@ http://purl.uniprot.org/uniprot/C7NDQ0 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/523794:LEBU_RS08940 ^@ http://purl.uniprot.org/uniprot/C7NBZ4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the BPG-independent phosphoglycerate mutase family.|||Binds 2 manganese ions per subunit.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS05170 ^@ http://purl.uniprot.org/uniprot/C7N9V6 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/523794:LEBU_RS03910 ^@ http://purl.uniprot.org/uniprot/C7N953 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/523794:LEBU_RS02630 ^@ http://purl.uniprot.org/uniprot/C7NER8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KdsA family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS11230 ^@ http://purl.uniprot.org/uniprot/C7NDY2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS09770 ^@ http://purl.uniprot.org/uniprot/C7NCI8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase H family.|||Cytoplasm|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/523794:LEBU_RS01085 ^@ http://purl.uniprot.org/uniprot/C7NDH0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/523794:LEBU_RS01200 ^@ http://purl.uniprot.org/uniprot/C7NDJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/523794:LEBU_RS04125 ^@ http://purl.uniprot.org/uniprot/C7N996 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS06790 ^@ http://purl.uniprot.org/uniprot/C7NAS9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS02640 ^@ http://purl.uniprot.org/uniprot/C7NES0 ^@ Similarity ^@ Belongs to the SIS family. GutQ/KpsF subfamily. http://togogenome.org/gene/523794:LEBU_RS00865 ^@ http://purl.uniprot.org/uniprot/C7NDD6 ^@ Function ^@ This protein is a component of the acetyl coenzyme A carboxylase complex; first, biotin carboxylase catalyzes the carboxylation of the carrier protein and then the transcarboxylase transfers the carboxyl group to form malonyl-CoA. http://togogenome.org/gene/523794:LEBU_RS04435 ^@ http://purl.uniprot.org/uniprot/C7N9F8 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/523794:LEBU_RS10155 ^@ http://purl.uniprot.org/uniprot/C7ND31 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS00600 ^@ http://purl.uniprot.org/uniprot/C7NCY1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RNA methyltransferase RsmG family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically methylates the N7 position of a guanine in 16S rRNA. http://togogenome.org/gene/523794:LEBU_RS11115 ^@ http://purl.uniprot.org/uniprot/C7NDW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GrpE family.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. http://togogenome.org/gene/523794:LEBU_RS06025 ^@ http://purl.uniprot.org/uniprot/C7NAC7 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/523794:LEBU_RS07030 ^@ http://purl.uniprot.org/uniprot/C7NAX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS03260 ^@ http://purl.uniprot.org/uniprot/C7N8S1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase delta chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/523794:LEBU_RS06120 ^@ http://purl.uniprot.org/uniprot/C7NAE4 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS00460 ^@ http://purl.uniprot.org/uniprot/C7NCV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS06300 ^@ http://purl.uniprot.org/uniprot/C7NAI2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxA subfamily.|||Cytoplasm|||Homotrimer.|||Involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/523794:LEBU_RS09110 ^@ http://purl.uniprot.org/uniprot/C7NC29 ^@ Similarity ^@ Belongs to the pseudouridine synthase RluA family. http://togogenome.org/gene/523794:LEBU_RS02210 ^@ http://purl.uniprot.org/uniprot/C7NEJ0 ^@ Similarity ^@ Belongs to the DtxR/MntR family. http://togogenome.org/gene/523794:LEBU_RS07105 ^@ http://purl.uniprot.org/uniprot/C7NAY7 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523794:LEBU_RS08100 ^@ http://purl.uniprot.org/uniprot/C7NBI3 ^@ Similarity ^@ Belongs to the tannase family. http://togogenome.org/gene/523794:LEBU_RS11005 ^@ http://purl.uniprot.org/uniprot/C7NDU6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose 3,5-epimerase family.|||Catalyzes the epimerization of the C3' and C5'positions of dTDP-6-deoxy-D-xylo-4-hexulose, forming dTDP-6-deoxy-L-lyxo-4-hexulose.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS00360 ^@ http://purl.uniprot.org/uniprot/C7NCT6 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Bacterial microcompartment|||Belongs to the PduL family.|||Formed by 2 beta-barrels, each is capped on both ends by short alpha-helices.|||Involved in 1,2-propanediol (1,2-PD) utilization within the bacterial microcompartment (BMC) dedicated to 1,2-PD degradation by catalyzing the conversion of propanoyl-CoA to propanoyl-phosphate.|||There are 2 Zn(2+) ions per monomer; Zn(2+) and CoA bind inbetween the 2 domains in each monomer. http://togogenome.org/gene/523794:LEBU_RS06965 ^@ http://purl.uniprot.org/uniprot/C7NAW4 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/523794:LEBU_RS05480 ^@ http://purl.uniprot.org/uniprot/C7NA21 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/523794:LEBU_RS08450 ^@ http://purl.uniprot.org/uniprot/C7NBQ1 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/523794:LEBU_RS05210 ^@ http://purl.uniprot.org/uniprot/C7N9W4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS05840 ^@ http://purl.uniprot.org/uniprot/C7NA91 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/523794:LEBU_RS08380 ^@ http://purl.uniprot.org/uniprot/C7NBN8 ^@ Domain|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/523794:LEBU_RS00080 ^@ http://purl.uniprot.org/uniprot/C7NCB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS05850 ^@ http://purl.uniprot.org/uniprot/C7NA93 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS01700 ^@ http://purl.uniprot.org/uniprot/C7NE56 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/523794:LEBU_RS05590 ^@ http://purl.uniprot.org/uniprot/C7NA44 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523794:LEBU_RS04860 ^@ http://purl.uniprot.org/uniprot/C7N9P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VirD4/TraG family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS01280 ^@ http://purl.uniprot.org/uniprot/C7NDL1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/523794:LEBU_RS10635 ^@ http://purl.uniprot.org/uniprot/C7NDB2 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/523794:LEBU_RS01745 ^@ http://purl.uniprot.org/uniprot/C7NE66 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. MTG1 subfamily.|||Cytoplasm|||Required for a late step of 50S ribosomal subunit assembly. Has GTPase activity. http://togogenome.org/gene/523794:LEBU_RS00280 ^@ http://purl.uniprot.org/uniprot/C7NCS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS03365 ^@ http://purl.uniprot.org/uniprot/C7N8U4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/523794:LEBU_RS07440 ^@ http://purl.uniprot.org/uniprot/C7NB50 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/523794:LEBU_RS09620 ^@ http://purl.uniprot.org/uniprot/C7NCF8 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/523794:LEBU_RS03640 ^@ http://purl.uniprot.org/uniprot/C7N8Z9 ^@ Cofactor|||Similarity ^@ Belongs to the iron-containing alcohol dehydrogenase family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/523794:LEBU_RS03885 ^@ http://purl.uniprot.org/uniprot/C7N948 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS01520 ^@ http://purl.uniprot.org/uniprot/C7NE21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS02855 ^@ http://purl.uniprot.org/uniprot/C7N8I9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09345 ^@ http://purl.uniprot.org/uniprot/C7NC71 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/523794:LEBU_RS11070 ^@ http://purl.uniprot.org/uniprot/C7NDV1 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/523794:LEBU_RS02275 ^@ http://purl.uniprot.org/uniprot/C7NEK3 ^@ Similarity ^@ Belongs to the CapA family. http://togogenome.org/gene/523794:LEBU_RS04195 ^@ http://purl.uniprot.org/uniprot/C7N9B0 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitant with their translocation across the cell membrane. http://togogenome.org/gene/523794:LEBU_RS07190 ^@ http://purl.uniprot.org/uniprot/C7NB02 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS04115 ^@ http://purl.uniprot.org/uniprot/C7N994 ^@ Similarity ^@ Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. http://togogenome.org/gene/523794:LEBU_RS07555 ^@ http://purl.uniprot.org/uniprot/C7NB74 ^@ Caution|||Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS07560 ^@ http://purl.uniprot.org/uniprot/C7NB75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS07150 ^@ http://purl.uniprot.org/uniprot/C7NAZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS08860 ^@ http://purl.uniprot.org/uniprot/C7NBY1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PPase class C family.|||Binds 2 manganese ions per subunit.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS10135 ^@ http://purl.uniprot.org/uniprot/C7ND27 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||This protein is involved in the repair of mismatches in DNA. It is possible that it carries out the mismatch recognition step. This protein has a weak ATPase activity. http://togogenome.org/gene/523794:LEBU_RS01275 ^@ http://purl.uniprot.org/uniprot/C7NDL0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/523794:LEBU_RS03310 ^@ http://purl.uniprot.org/uniprot/C7N8T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate:Na(+) symporter (ESS) (TC 2.A.27) family.|||Catalyzes the sodium-dependent transport of glutamate.|||Cell inner membrane http://togogenome.org/gene/523794:LEBU_RS03400 ^@ http://purl.uniprot.org/uniprot/C7N8V1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS04760 ^@ http://purl.uniprot.org/uniprot/C7N9M0 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/523794:LEBU_RS03925 ^@ http://purl.uniprot.org/uniprot/C7N956 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/523794:LEBU_RS07855 ^@ http://purl.uniprot.org/uniprot/C7NBD4 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/523794:LEBU_RS03145 ^@ http://purl.uniprot.org/uniprot/C7N8P8 ^@ Similarity ^@ Belongs to the peptidase A24 family. http://togogenome.org/gene/523794:LEBU_RS01735 ^@ http://purl.uniprot.org/uniprot/C7NE64 ^@ Similarity ^@ Belongs to the peptidase S41A family. http://togogenome.org/gene/523794:LEBU_RS07435 ^@ http://purl.uniprot.org/uniprot/C7NB49 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by acpS.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS07040 ^@ http://purl.uniprot.org/uniprot/C7NAX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS07085 ^@ http://purl.uniprot.org/uniprot/C7NAY3 ^@ Similarity ^@ Belongs to the LysR transcriptional regulatory family. http://togogenome.org/gene/523794:LEBU_RS11190 ^@ http://purl.uniprot.org/uniprot/C7NDX5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/523794:LEBU_RS08390 ^@ http://purl.uniprot.org/uniprot/C7NBP0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS10410 ^@ http://purl.uniprot.org/uniprot/C7ND72 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/523794:LEBU_RS02055 ^@ http://purl.uniprot.org/uniprot/C7NEC6 ^@ Similarity ^@ Belongs to the UPF0237 family. http://togogenome.org/gene/523794:LEBU_RS03835 ^@ http://purl.uniprot.org/uniprot/C7N938 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/523794:LEBU_RS09545 ^@ http://purl.uniprot.org/uniprot/C7NCE3 ^@ Similarity ^@ Belongs to the Dps family. http://togogenome.org/gene/523794:LEBU_RS02430 ^@ http://purl.uniprot.org/uniprot/C7NEM8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the ApbE family.|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein.|||Magnesium. Can also use manganese. http://togogenome.org/gene/523794:LEBU_RS06060 ^@ http://purl.uniprot.org/uniprot/C7NAD4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/523794:LEBU_RS10465 ^@ http://purl.uniprot.org/uniprot/C7ND80 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 Fe(2+) ion per subunit.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaE and TsaB. TsaD likely plays a direct catalytic role in this reaction. http://togogenome.org/gene/523794:LEBU_RS00670 ^@ http://purl.uniprot.org/uniprot/C7NCZ1 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/523794:LEBU_RS03435 ^@ http://purl.uniprot.org/uniprot/C7N8V8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thymidylate synthase family. Bacterial-type ThyA subfamily.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by-product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05835 ^@ http://purl.uniprot.org/uniprot/C7NA90 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/523794:LEBU_RS03510 ^@ http://purl.uniprot.org/uniprot/C7N8X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase group 1 family.|||Cell membrane|||Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of 3-deoxy-D-manno-octulosonate (Kdo) residue(s) from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. http://togogenome.org/gene/523794:LEBU_RS07570 ^@ http://purl.uniprot.org/uniprot/C7NB77 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03325 ^@ http://purl.uniprot.org/uniprot/C7N8T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAE transporter (TC 2.A.81) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS03240 ^@ http://purl.uniprot.org/uniprot/C7N8R7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase A chain family.|||Cell inner membrane|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the proton channel; it plays a direct role in the translocation of protons across the membrane.|||Membrane http://togogenome.org/gene/523794:LEBU_RS03710 ^@ http://purl.uniprot.org/uniprot/C7N913 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA(Ile)-lysidine synthase family.|||Cytoplasm|||Ligates lysine onto the cytidine present at position 34 of the AUA codon-specific tRNA(Ile) that contains the anticodon CAU, in an ATP-dependent manner. Cytidine is converted to lysidine, thus changing the amino acid specificity of the tRNA from methionine to isoleucine.|||The N-terminal region contains the highly conserved SGGXDS motif, predicted to be a P-loop motif involved in ATP binding. http://togogenome.org/gene/523794:LEBU_RS03360 ^@ http://purl.uniprot.org/uniprot/C7N8U3 ^@ Similarity ^@ Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family. http://togogenome.org/gene/523794:LEBU_RS05115 ^@ http://purl.uniprot.org/uniprot/C7N9U5 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/523794:LEBU_RS08665 ^@ http://purl.uniprot.org/uniprot/C7NBU3 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/523794:LEBU_RS05275 ^@ http://purl.uniprot.org/uniprot/C7N9X7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A monovalent cation. Ammonium or potassium.|||Belongs to the type III pantothenate kinase family.|||Catalyzes the phosphorylation of pantothenate (Pan), the first step in CoA biosynthesis.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03115 ^@ http://purl.uniprot.org/uniprot/C7N8P2 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/523794:LEBU_RS02135 ^@ http://purl.uniprot.org/uniprot/C7NEH5 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/523794:LEBU_RS04405 ^@ http://purl.uniprot.org/uniprot/C7N9F2 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/523794:LEBU_RS02500 ^@ http://purl.uniprot.org/uniprot/C7NEP2 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/523794:LEBU_RS07700 ^@ http://purl.uniprot.org/uniprot/C7NBA2 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/523794:LEBU_RS07540 ^@ http://purl.uniprot.org/uniprot/C7NB69 ^@ Domain|||Function|||Subcellular Location Annotation ^@ Cell membrane|||The EIIB domain is phosphorylated by phospho-EIIA on a cysteinyl or histidyl residue, depending on the transported sugar. Then, it transfers the phosphoryl group to the sugar substrate concomitantly with the sugar uptake processed by the EIIC domain.|||The EIIC domain forms the PTS system translocation channel and contains the specific substrate-binding site.|||The phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS), a major carbohydrate active -transport system, catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. This system is probably involved in transport of the alpha-glucosides trehalulose, turanose, maltulose and palatinose. http://togogenome.org/gene/523794:LEBU_RS07850 ^@ http://purl.uniprot.org/uniprot/C7NBD3 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/523794:LEBU_RS06460 ^@ http://purl.uniprot.org/uniprot/C7NAL4 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/523794:LEBU_RS08545 ^@ http://purl.uniprot.org/uniprot/C7NBR9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/523794:LEBU_RS06085 ^@ http://purl.uniprot.org/uniprot/C7NAD8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/523794:LEBU_RS03105 ^@ http://purl.uniprot.org/uniprot/C7N8P0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03045 ^@ http://purl.uniprot.org/uniprot/C7N8M8 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS07305 ^@ http://purl.uniprot.org/uniprot/C7NB25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Cytoplasm|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine. http://togogenome.org/gene/523794:LEBU_RS00210 ^@ http://purl.uniprot.org/uniprot/C7NCQ7 ^@ Function|||Similarity ^@ Belongs to the CobB/CobQ family. CobQ subfamily.|||Catalyzes amidations at positions B, D, E, and G on adenosylcobyrinic A,C-diamide. NH(2) groups are provided by glutamine, and one molecule of ATP is hydrogenolyzed for each amidation. http://togogenome.org/gene/523794:LEBU_RS06810 ^@ http://purl.uniprot.org/uniprot/C7NAT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial sugar transferase family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS05105 ^@ http://purl.uniprot.org/uniprot/C7N9U3 ^@ Similarity ^@ Belongs to the type-I restriction system S methylase family. http://togogenome.org/gene/523794:LEBU_RS04450 ^@ http://purl.uniprot.org/uniprot/C7N9G1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS04280 ^@ http://purl.uniprot.org/uniprot/C7N9C7 ^@ Similarity ^@ Belongs to the HMG-CoA reductase family. http://togogenome.org/gene/523794:LEBU_RS04210 ^@ http://purl.uniprot.org/uniprot/C7N9B3 ^@ Cofactor ^@ Binds 1 Mg(2+) ion per trimer. http://togogenome.org/gene/523794:LEBU_RS03780 ^@ http://purl.uniprot.org/uniprot/C7N927 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/523794:LEBU_RS11270 ^@ http://purl.uniprot.org/uniprot/C7NDZ0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03525 ^@ http://purl.uniprot.org/uniprot/C7N8X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS01430 ^@ http://purl.uniprot.org/uniprot/C7NDN6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peroxiredoxin family. AhpC/Prx1 subfamily.|||Cytoplasm|||Homodimer.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/523794:LEBU_RS07575 ^@ http://purl.uniprot.org/uniprot/C7NB78 ^@ Similarity ^@ Belongs to the SAICAR synthetase family. http://togogenome.org/gene/523794:LEBU_RS10895 ^@ http://purl.uniprot.org/uniprot/C7NDS5 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS08060 ^@ http://purl.uniprot.org/uniprot/C7NBH5 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/523794:LEBU_RS03970 ^@ http://purl.uniprot.org/uniprot/C7N965 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08710 ^@ http://purl.uniprot.org/uniprot/C7NBV1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the queuine tRNA-ribosyltransferase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the base-exchange of a guanine (G) residue with the queuine precursor 7-aminomethyl-7-deazaguanine (PreQ1) at position 34 (anticodon wobble position) in tRNAs with GU(N) anticodons (tRNA-Asp, -Asn, -His and -Tyr). Catalysis occurs through a double-displacement mechanism. The nucleophile active site attacks the C1' of nucleotide 34 to detach the guanine base from the RNA, forming a covalent enzyme-RNA intermediate. The proton acceptor active site deprotonates the incoming PreQ1, allowing a nucleophilic attack on the C1' of the ribose to form the product. After dissociation, two additional enzymatic reactions on the tRNA convert PreQ1 to queuine (Q), resulting in the hypermodified nucleoside queuosine (7-(((4,5-cis-dihydroxy-2-cyclopenten-1-yl)amino)methyl)-7-deazaguanosine).|||Homodimer. Within each dimer, one monomer is responsible for RNA recognition and catalysis, while the other monomer binds to the replacement base PreQ1. http://togogenome.org/gene/523794:LEBU_RS04110 ^@ http://purl.uniprot.org/uniprot/C7N993 ^@ Similarity ^@ Belongs to the outer membrane factor (OMF) (TC 1.B.17) family. http://togogenome.org/gene/523794:LEBU_RS01265 ^@ http://purl.uniprot.org/uniprot/C7NDK8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS01975 ^@ http://purl.uniprot.org/uniprot/C7NEB1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL31 family. http://togogenome.org/gene/523794:LEBU_RS10085 ^@ http://purl.uniprot.org/uniprot/C7NCP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc. http://togogenome.org/gene/523794:LEBU_RS04285 ^@ http://purl.uniprot.org/uniprot/C7N9C8 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/523794:LEBU_RS10770 ^@ http://purl.uniprot.org/uniprot/C7NDP8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/523794:LEBU_RS09625 ^@ http://purl.uniprot.org/uniprot/C7NCF9 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS03210 ^@ http://purl.uniprot.org/uniprot/C7N8R1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/523794:LEBU_RS04105 ^@ http://purl.uniprot.org/uniprot/C7N992 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS08805 ^@ http://purl.uniprot.org/uniprot/C7NBX0 ^@ Function|||PTM|||Similarity ^@ Belongs to the NAPRTase family.|||Catalyzes the synthesis of beta-nicotinate D-ribonucleotide from nicotinate and 5-phospho-D-ribose 1-phosphate at the expense of ATP.|||Transiently phosphorylated on a His residue during the reaction cycle. Phosphorylation strongly increases the affinity for substrates and increases the rate of nicotinate D-ribonucleotide production. Dephosphorylation regenerates the low-affinity form of the enzyme, leading to product release. http://togogenome.org/gene/523794:LEBU_RS08660 ^@ http://purl.uniprot.org/uniprot/C7NBU2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/523794:LEBU_RS03190 ^@ http://purl.uniprot.org/uniprot/C7N8Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSP F family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS00765 ^@ http://purl.uniprot.org/uniprot/C7ND10 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/523794:LEBU_RS01240 ^@ http://purl.uniprot.org/uniprot/C7NDK3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/523794:LEBU_RS08325 ^@ http://purl.uniprot.org/uniprot/C7NBM7 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/523794:LEBU_RS01260 ^@ http://purl.uniprot.org/uniprot/C7NDK7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/523794:LEBU_RS04140 ^@ http://purl.uniprot.org/uniprot/C7N999 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/523794:LEBU_RS08645 ^@ http://purl.uniprot.org/uniprot/C7NBT9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/523794:LEBU_RS07155 ^@ http://purl.uniprot.org/uniprot/C7NAZ6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the radical SAM superfamily. Biotin synthase family.|||Binds 1 [2Fe-2S] cluster. The cluster is coordinated with 3 cysteines and 1 arginine.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS00750 ^@ http://purl.uniprot.org/uniprot/C7ND07 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS03805 ^@ http://purl.uniprot.org/uniprot/C7N932 ^@ Function|||Similarity ^@ Belongs to the V-ATPase E subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523794:LEBU_RS10645 ^@ http://purl.uniprot.org/uniprot/C7NDB4 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. NagB subfamily.|||Catalyzes the reversible isomerization-deamination of glucosamine 6-phosphate (GlcN6P) to form fructose 6-phosphate (Fru6P) and ammonium ion.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS02860 ^@ http://purl.uniprot.org/uniprot/C7N8J0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 1 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||The C-terminal coiled-coil domain is crucial for aminoacylation activity.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/523794:LEBU_RS07430 ^@ http://purl.uniprot.org/uniprot/C7NB48 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/523794:LEBU_RS09225 ^@ http://purl.uniprot.org/uniprot/C7NC46 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/523794:LEBU_RS07380 ^@ http://purl.uniprot.org/uniprot/C7NB38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS03280 ^@ http://purl.uniprot.org/uniprot/C7N8S5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523794:LEBU_RS02975 ^@ http://purl.uniprot.org/uniprot/C7N8L5 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/523794:LEBU_RS04985 ^@ http://purl.uniprot.org/uniprot/C7N9R9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/523794:LEBU_RS09645 ^@ http://purl.uniprot.org/uniprot/C7NCG3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS05380 ^@ http://purl.uniprot.org/uniprot/C7NA01 ^@ Similarity ^@ Belongs to the UPF0236 family. http://togogenome.org/gene/523794:LEBU_RS03440 ^@ http://purl.uniprot.org/uniprot/C7N8V9 ^@ Function|||Similarity ^@ Belongs to the dihydrofolate reductase family.|||Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis. http://togogenome.org/gene/523794:LEBU_RS04300 ^@ http://purl.uniprot.org/uniprot/C7N9D1 ^@ Function|||Similarity ^@ Belongs to the MreC family.|||Involved in formation and maintenance of cell shape. http://togogenome.org/gene/523794:LEBU_RS10205 ^@ http://purl.uniprot.org/uniprot/C7ND42 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/523794:LEBU_RS06455 ^@ http://purl.uniprot.org/uniprot/C7NAL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS07975 ^@ http://purl.uniprot.org/uniprot/C7NBF8 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS01075 ^@ http://purl.uniprot.org/uniprot/C7NDG8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family.|||Binds together with S18 to 16S ribosomal RNA. http://togogenome.org/gene/523794:LEBU_RS06140 ^@ http://purl.uniprot.org/uniprot/C7NAE8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP phosphoribosyltransferase family. Short subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Heteromultimer composed of HisG and HisZ subunits.|||Lacks the C-terminal regulatory region which is replaced by HisZ. http://togogenome.org/gene/523794:LEBU_RS03600 ^@ http://purl.uniprot.org/uniprot/C7N8Z1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CorA metal ion transporter (MIT) (TC 1.A.35) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS02905 ^@ http://purl.uniprot.org/uniprot/C7N8K1 ^@ Similarity ^@ Belongs to the flavin oxidoreductase frp family. http://togogenome.org/gene/523794:LEBU_RS10165 ^@ http://purl.uniprot.org/uniprot/C7ND34 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/523794:LEBU_RS09960 ^@ http://purl.uniprot.org/uniprot/C7NCM5 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/523794:LEBU_RS03125 ^@ http://purl.uniprot.org/uniprot/C7N8P4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/523794:LEBU_RS00375 ^@ http://purl.uniprot.org/uniprot/C7NCT9 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/523794:LEBU_RS07215 ^@ http://purl.uniprot.org/uniprot/C7NB07 ^@ Domain|||Function|||Similarity ^@ Belongs to the vitamin-B12 dependent methionine synthase family.|||Catalyzes the transfer of a methyl group from methyl-cobalamin to homocysteine, yielding enzyme-bound cob(I)alamin and methionine. Subsequently, remethylates the cofactor using methyltetrahydrofolate.|||Modular enzyme with four functionally distinct domains. The isolated Hcy-binding domain catalyzes methyl transfer from free methylcobalamin to homocysteine. The Hcy-binding domain in association with the pterin-binding domain catalyzes the methylation of cob(I)alamin by methyltetrahydrofolate and the methylation of homocysteine. The B12-binding domain binds the cofactor. The AdoMet activation domain binds S-adenosyl-L-methionine. Under aerobic conditions cob(I)alamin can be converted to inactive cob(II)alamin. Reductive methylation by S-adenosyl-L-methionine and flavodoxin regenerates methylcobalamin. http://togogenome.org/gene/523794:LEBU_RS03545 ^@ http://purl.uniprot.org/uniprot/C7N8Y0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS06800 ^@ http://purl.uniprot.org/uniprot/C7NAT1 ^@ Similarity ^@ Belongs to the MlaA family. http://togogenome.org/gene/523794:LEBU_RS08265 ^@ http://purl.uniprot.org/uniprot/C7NBL5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IPP isomerase type 2 family.|||Cytoplasm|||Homooctamer. Dimer of tetramers.|||Involved in the biosynthesis of isoprenoids. Catalyzes the 1,3-allylic rearrangement of the homoallylic substrate isopentenyl (IPP) to its allylic isomer, dimethylallyl diphosphate (DMAPP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS01185 ^@ http://purl.uniprot.org/uniprot/C7NDJ2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/523794:LEBU_RS00815 ^@ http://purl.uniprot.org/uniprot/C7ND19 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/523794:LEBU_RS05785 ^@ http://purl.uniprot.org/uniprot/C7NA81 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/523794:LEBU_RS00735 ^@ http://purl.uniprot.org/uniprot/C7ND04 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Composed of three domains: the N-terminal N domain, which is responsible for interactions with the ribosome, the central G domain, which binds GTP, and the C-terminal M domain, which binds the RNA and the signal sequence of the RNC.|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Binds to the hydrophobic signal sequence of the ribosome-nascent chain (RNC) as it emerges from the ribosomes. The SRP-RNC complex is then targeted to the cytoplasmic membrane where it interacts with the SRP receptor FtsY.|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/523794:LEBU_RS03815 ^@ http://purl.uniprot.org/uniprot/C7N934 ^@ Function|||Similarity ^@ Belongs to the V-ATPase F subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523794:LEBU_RS09820 ^@ http://purl.uniprot.org/uniprot/C7NCJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS02990 ^@ http://purl.uniprot.org/uniprot/C7N8L8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS08760 ^@ http://purl.uniprot.org/uniprot/C7NBW2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the transferase hexapeptide repeat family. LpxD subfamily.|||Catalyzes the N-acylation of UDP-3-O-acylglucosamine using 3-hydroxyacyl-ACP as the acyl donor. Is involved in the biosynthesis of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell.|||Homotrimer. http://togogenome.org/gene/523794:LEBU_RS07680 ^@ http://purl.uniprot.org/uniprot/C7NB98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. AsnA subfamily.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS00420 ^@ http://purl.uniprot.org/uniprot/C7NCU6 ^@ Similarity ^@ Belongs to the YoeB family. http://togogenome.org/gene/523794:LEBU_RS04010 ^@ http://purl.uniprot.org/uniprot/C7N973 ^@ Similarity ^@ In the N-terminal section; belongs to the CRISPR-associated nuclease Cas3-HD family.|||In the central section; belongs to the CRISPR-associated helicase Cas3 family. http://togogenome.org/gene/523794:LEBU_RS03370 ^@ http://purl.uniprot.org/uniprot/C7N8U5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 32 family.|||Cytoplasm|||Enables the bacterium to metabolize sucrose as a sole carbon source. http://togogenome.org/gene/523794:LEBU_RS01525 ^@ http://purl.uniprot.org/uniprot/C7NE22 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523794:LEBU_RS08210 ^@ http://purl.uniprot.org/uniprot/C7NBK4 ^@ Function|||Similarity|||Subunit ^@ Antiterminator that binds to cis-acting regulatory sequences on the mRNA in the presence of histidine, thereby suppressing transcription termination and activating the hut operon for histidine utilization.|||Belongs to the HutP family.|||Homohexamer. http://togogenome.org/gene/523794:LEBU_RS01220 ^@ http://purl.uniprot.org/uniprot/C7NDJ9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/523794:LEBU_RS04870 ^@ http://purl.uniprot.org/uniprot/C7N9P3 ^@ Similarity ^@ Belongs to the TrbG/VirB9 family. http://togogenome.org/gene/523794:LEBU_RS10265 ^@ http://purl.uniprot.org/uniprot/C7ND49 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the tRNA pseudouridine synthase TruA family.|||Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS01170 ^@ http://purl.uniprot.org/uniprot/C7NDI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptide transporter carbon starvation (CstA) (TC 2.A.114) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS10405 ^@ http://purl.uniprot.org/uniprot/C7ND71 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/523794:LEBU_RS11590 ^@ http://purl.uniprot.org/uniprot/C7N9P2 ^@ Similarity ^@ Belongs to the TrbI/VirB10 family. http://togogenome.org/gene/523794:LEBU_RS09320 ^@ http://purl.uniprot.org/uniprot/C7NC66 ^@ Similarity ^@ Belongs to the peptidase S11 family. http://togogenome.org/gene/523794:LEBU_RS08185 ^@ http://purl.uniprot.org/uniprot/C7NBJ9 ^@ Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily. http://togogenome.org/gene/523794:LEBU_RS11520 ^@ http://purl.uniprot.org/uniprot/C7NEG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OXA1/ALB3/YidC family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS01940 ^@ http://purl.uniprot.org/uniprot/C7NEA4 ^@ Similarity ^@ Belongs to the RecJ family. http://togogenome.org/gene/523794:LEBU_RS06245 ^@ http://purl.uniprot.org/uniprot/C7NAH1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS02870 ^@ http://purl.uniprot.org/uniprot/C7N8J4 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/523794:LEBU_RS06220 ^@ http://purl.uniprot.org/uniprot/C7NAG5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell inner membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS00855 ^@ http://purl.uniprot.org/uniprot/C7NDD4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transcriptional regulatory Rex family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Modulates transcription in response to changes in cellular NADH/NAD(+) redox state. http://togogenome.org/gene/523794:LEBU_RS00530 ^@ http://purl.uniprot.org/uniprot/C7NCW8 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS00660 ^@ http://purl.uniprot.org/uniprot/C7NCY9 ^@ Similarity|||Subunit ^@ Belongs to the KdsC family.|||Homotetramer. http://togogenome.org/gene/523794:LEBU_RS02370 ^@ http://purl.uniprot.org/uniprot/C7NEL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/523794:LEBU_RS09010 ^@ http://purl.uniprot.org/uniprot/C7NC08 ^@ Similarity ^@ Belongs to the arginase family. Agmatinase subfamily. http://togogenome.org/gene/523794:LEBU_RS03810 ^@ http://purl.uniprot.org/uniprot/C7N933 ^@ Similarity ^@ Belongs to the V-ATPase V0D/AC39 subunit family. http://togogenome.org/gene/523794:LEBU_RS01690 ^@ http://purl.uniprot.org/uniprot/C7NE54 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/523794:LEBU_RS00310 ^@ http://purl.uniprot.org/uniprot/C7NCS6 ^@ Subcellular Location Annotation ^@ Bacterial microcompartment http://togogenome.org/gene/523794:LEBU_RS07580 ^@ http://purl.uniprot.org/uniprot/C7NB79 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/523794:LEBU_RS05280 ^@ http://purl.uniprot.org/uniprot/C7N9X8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08490 ^@ http://purl.uniprot.org/uniprot/C7NBQ7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08740 ^@ http://purl.uniprot.org/uniprot/C7NBV7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS01300 ^@ http://purl.uniprot.org/uniprot/C7NDL5 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS02880 ^@ http://purl.uniprot.org/uniprot/C7N8J6 ^@ Subcellular Location Annotation ^@ Cell inner membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS06510 ^@ http://purl.uniprot.org/uniprot/C7NAM3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/523794:LEBU_RS02535 ^@ http://purl.uniprot.org/uniprot/C7NEP9 ^@ Similarity ^@ Belongs to the formate--tetrahydrofolate ligase family. http://togogenome.org/gene/523794:LEBU_RS05720 ^@ http://purl.uniprot.org/uniprot/C7NA68 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/523794:LEBU_RS04990 ^@ http://purl.uniprot.org/uniprot/C7N9S0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/523794:LEBU_RS05725 ^@ http://purl.uniprot.org/uniprot/C7NA69 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/523794:LEBU_RS10420 ^@ http://purl.uniprot.org/uniprot/C7ND74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M50B family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS03195 ^@ http://purl.uniprot.org/uniprot/C7N8Q8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family.|||Catalyzes the methylation of 5-hydroxyuridine (ho5U) to form 5-methoxyuridine (mo5U) at position 34 in tRNAs.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS02340 ^@ http://purl.uniprot.org/uniprot/C7NEL0 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523794:LEBU_RS09935 ^@ http://purl.uniprot.org/uniprot/C7NCM0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/523794:LEBU_RS09015 ^@ http://purl.uniprot.org/uniprot/C7NC09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the spermidine/spermine synthase family.|||Catalyzes the irreversible transfer of a propylamine group from the amino donor S-adenosylmethioninamine (decarboxy-AdoMet) to putrescine (1,4-diaminobutane) to yield spermidine.|||Homodimer or homotetramer. http://togogenome.org/gene/523794:LEBU_RS08285 ^@ http://purl.uniprot.org/uniprot/C7NBL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/523794:LEBU_RS05015 ^@ http://purl.uniprot.org/uniprot/C7N9S5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09680 ^@ http://purl.uniprot.org/uniprot/C7NCH0 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/523794:LEBU_RS07070 ^@ http://purl.uniprot.org/uniprot/C7NAY1 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/523794:LEBU_RS08250 ^@ http://purl.uniprot.org/uniprot/C7NBL2 ^@ Function|||Subcellular Location Annotation ^@ Catalyzes the Claisen rearrangement of chorismate to prephenate and the decarboxylation/dehydration of prephenate to phenylpyruvate.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS02620 ^@ http://purl.uniprot.org/uniprot/C7NER6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Lgt family.|||Catalyzes the transfer of the diacylglyceryl group from phosphatidylglycerol to the sulfhydryl group of the N-terminal cysteine of a prolipoprotein, the first step in the formation of mature lipoproteins.|||Cell inner membrane http://togogenome.org/gene/523794:LEBU_RS11455 ^@ http://purl.uniprot.org/uniprot/C7NEE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS07970 ^@ http://purl.uniprot.org/uniprot/C7NBF7 ^@ Similarity|||Subunit ^@ Belongs to the CarA family.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate. http://togogenome.org/gene/523794:LEBU_RS09025 ^@ http://purl.uniprot.org/uniprot/C7NC11 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-I family. http://togogenome.org/gene/523794:LEBU_RS05540 ^@ http://purl.uniprot.org/uniprot/C7NA33 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/523794:LEBU_RS04090 ^@ http://purl.uniprot.org/uniprot/C7N989 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/523794:LEBU_RS03670 ^@ http://purl.uniprot.org/uniprot/C7N905 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphopentomutase family.|||Binds 1 or 2 manganese ions.|||Cytoplasm|||Phosphotransfer between the C1 and C5 carbon atoms of pentose. http://togogenome.org/gene/523794:LEBU_RS02440 ^@ http://purl.uniprot.org/uniprot/C7NEN0 ^@ Similarity ^@ In the C-terminal section; belongs to the transposase 35 family.|||In the N-terminal section; belongs to the transposase 2 family. http://togogenome.org/gene/523794:LEBU_RS10710 ^@ http://purl.uniprot.org/uniprot/C7NDC2 ^@ Function|||Similarity ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family.|||Catalyzes the reduction of dTDP-6-deoxy-L-lyxo-4-hexulose to yield dTDP-L-rhamnose. http://togogenome.org/gene/523794:LEBU_RS11530 ^@ http://purl.uniprot.org/uniprot/C7NEG4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/523794:LEBU_RS08770 ^@ http://purl.uniprot.org/uniprot/C7NBW4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03405 ^@ http://purl.uniprot.org/uniprot/C7N8V2 ^@ Similarity ^@ Belongs to the RutC family. http://togogenome.org/gene/523794:LEBU_RS03010 ^@ http://purl.uniprot.org/uniprot/C7N8M2 ^@ Function|||Similarity ^@ Antitoxin component of a type II toxin-antitoxin (TA) system.|||Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/523794:LEBU_RS00265 ^@ http://purl.uniprot.org/uniprot/C7NCR8 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the peroxiredoxin family. Tpx subfamily.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. http://togogenome.org/gene/523794:LEBU_RS09725 ^@ http://purl.uniprot.org/uniprot/C7NCH9 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/523794:LEBU_RS04375 ^@ http://purl.uniprot.org/uniprot/C7N9E6 ^@ Similarity ^@ Belongs to the PHP hydrolase family. HisK subfamily. http://togogenome.org/gene/523794:LEBU_RS03705 ^@ http://purl.uniprot.org/uniprot/C7N912 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglycosylase MltG family.|||Cell inner membrane|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/523794:LEBU_RS10325 ^@ http://purl.uniprot.org/uniprot/C7ND60 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08385 ^@ http://purl.uniprot.org/uniprot/C7NBN9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecX family.|||Cytoplasm|||Modulates RecA activity. http://togogenome.org/gene/523794:LEBU_RS04245 ^@ http://purl.uniprot.org/uniprot/C7N9C0 ^@ Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS05600 ^@ http://purl.uniprot.org/uniprot/C7NA45 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/523794:LEBU_RS09745 ^@ http://purl.uniprot.org/uniprot/C7NCI3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CutC family.|||Cytoplasm|||Once thought to be involved in copper homeostasis, experiments in E.coli have shown this is not the case. http://togogenome.org/gene/523794:LEBU_RS00685 ^@ http://purl.uniprot.org/uniprot/C7NCZ4 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 3 Mg(2+) ions per subunit.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS09685 ^@ http://purl.uniprot.org/uniprot/C7NCH1 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS08955 ^@ http://purl.uniprot.org/uniprot/C7NBZ7 ^@ Similarity ^@ Belongs to the EfeM/EfeO family. http://togogenome.org/gene/523794:LEBU_RS06365 ^@ http://purl.uniprot.org/uniprot/C7NAJ5 ^@ Similarity ^@ Belongs to the nitroreductase family. http://togogenome.org/gene/523794:LEBU_RS06860 ^@ http://purl.uniprot.org/uniprot/C7NAU3 ^@ Similarity ^@ Belongs to the NAPRTase family. http://togogenome.org/gene/523794:LEBU_RS09390 ^@ http://purl.uniprot.org/uniprot/C7NC80 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/523794:LEBU_RS11280 ^@ http://purl.uniprot.org/uniprot/C7NDZ2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS09220 ^@ http://purl.uniprot.org/uniprot/C7NC45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ThiI family.|||Catalyzes the ATP-dependent transfer of a sulfur to tRNA to produce 4-thiouridine in position 8 of tRNAs, which functions as a near-UV photosensor. Also catalyzes the transfer of sulfur to the sulfur carrier protein ThiS, forming ThiS-thiocarboxylate. This is a step in the synthesis of thiazole, in the thiamine biosynthesis pathway. The sulfur is donated as persulfide by IscS.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS10790 ^@ http://purl.uniprot.org/uniprot/C7NDQ2 ^@ Function|||Similarity ^@ Belongs to the glucose-1-phosphate thymidylyltransferase family.|||Catalyzes the formation of dTDP-glucose, from dTTP and glucose 1-phosphate, as well as its pyrophosphorolysis. http://togogenome.org/gene/523794:LEBU_RS00065 ^@ http://purl.uniprot.org/uniprot/C7NCA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/523794:LEBU_RS10885 ^@ http://purl.uniprot.org/uniprot/C7NDS3 ^@ Similarity ^@ Belongs to the Glu/Leu/Phe/Val dehydrogenases family. http://togogenome.org/gene/523794:LEBU_RS02395 ^@ http://purl.uniprot.org/uniprot/C7NEM1 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/523794:LEBU_RS07660 ^@ http://purl.uniprot.org/uniprot/C7NB94 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS10130 ^@ http://purl.uniprot.org/uniprot/C7ND26 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/523794:LEBU_RS10590 ^@ http://purl.uniprot.org/uniprot/C7NDA3 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/523794:LEBU_RS04890 ^@ http://purl.uniprot.org/uniprot/C7N9P8 ^@ Similarity ^@ Belongs to the MobA/MobL family. http://togogenome.org/gene/523794:LEBU_RS05620 ^@ http://purl.uniprot.org/uniprot/C7NA48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNT transporter (TC 2.A.44) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS04255 ^@ http://purl.uniprot.org/uniprot/C7N9C2 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS07740 ^@ http://purl.uniprot.org/uniprot/C7NBB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS08340 ^@ http://purl.uniprot.org/uniprot/C7NBN0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20B family.|||Binds 2 Zn(2+) ions per subunit.|||Cleaves the N-terminal amino acid of tripeptides.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS08890 ^@ http://purl.uniprot.org/uniprot/C7NBY7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/523794:LEBU_RS02845 ^@ http://purl.uniprot.org/uniprot/C7N8I8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS00495 ^@ http://purl.uniprot.org/uniprot/C7NCW0 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS00250 ^@ http://purl.uniprot.org/uniprot/C7NCR5 ^@ Similarity ^@ Belongs to the UPF0236 family. http://togogenome.org/gene/523794:LEBU_RS02420 ^@ http://purl.uniprot.org/uniprot/C7NEM6 ^@ Activity Regulation|||Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Inhibited by fructose 1,6-bisphosphate (FBP).|||Key enzyme in the regulation of glycerol uptake and metabolism. Catalyzes the phosphorylation of glycerol to yield sn-glycerol 3-phosphate. http://togogenome.org/gene/523794:LEBU_RS06530 ^@ http://purl.uniprot.org/uniprot/C7NAM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RimP family.|||Cytoplasm|||Required for maturation of 30S ribosomal subunits. http://togogenome.org/gene/523794:LEBU_RS03025 ^@ http://purl.uniprot.org/uniprot/C7N8M4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Cell membrane|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523794:LEBU_RS08510 ^@ http://purl.uniprot.org/uniprot/C7NBR2 ^@ Similarity ^@ Belongs to the RelB/DinJ antitoxin family. http://togogenome.org/gene/523794:LEBU_RS01730 ^@ http://purl.uniprot.org/uniprot/C7NE63 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/523794:LEBU_RS09080 ^@ http://purl.uniprot.org/uniprot/C7NC23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS09415 ^@ http://purl.uniprot.org/uniprot/C7NC84 ^@ Function|||Similarity ^@ Allosteric enzyme that catalyzes the rate-limiting step in glycogen catabolism, the phosphorolytic cleavage of glycogen to produce glucose-1-phosphate, and plays a central role in maintaining cellular and organismal glucose homeostasis.|||Belongs to the glycogen phosphorylase family.|||Phosphorylase is an important allosteric enzyme in carbohydrate metabolism. Enzymes from different sources differ in their regulatory mechanisms and in their natural substrates. However, all known phosphorylases share catalytic and structural properties. http://togogenome.org/gene/523794:LEBU_RS01800 ^@ http://purl.uniprot.org/uniprot/C7NE77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS10395 ^@ http://purl.uniprot.org/uniprot/C7ND69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09115 ^@ http://purl.uniprot.org/uniprot/C7NC30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS06710 ^@ http://purl.uniprot.org/uniprot/C7NAR3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to 4-hydroxy-tetrahydrodipicolinate (HTPA).|||Cytoplasm|||Homotetramer; dimer of dimers.|||Was originally thought to be a dihydrodipicolinate synthase (DHDPS), catalyzing the condensation of (S)-aspartate-beta-semialdehyde [(S)-ASA] and pyruvate to dihydrodipicolinate (DHDP). However, it was shown in E.coli that the product of the enzymatic reaction is not dihydrodipicolinate but in fact (4S)-4-hydroxy-2,3,4,5-tetrahydro-(2S)-dipicolinic acid (HTPA), and that the consecutive dehydration reaction leading to DHDP is not spontaneous but catalyzed by DapB. http://togogenome.org/gene/523794:LEBU_RS05845 ^@ http://purl.uniprot.org/uniprot/C7NA92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family. Azg-like subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS09735 ^@ http://purl.uniprot.org/uniprot/C7NCI1 ^@ Similarity ^@ Belongs to the 5'-nucleotidase family. http://togogenome.org/gene/523794:LEBU_RS08375 ^@ http://purl.uniprot.org/uniprot/C7NBN7 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/523794:LEBU_RS01215 ^@ http://purl.uniprot.org/uniprot/C7NDJ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS03595 ^@ http://purl.uniprot.org/uniprot/C7N8Z0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523794:LEBU_RS06255 ^@ http://purl.uniprot.org/uniprot/C7NAH3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MetA family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/523794:LEBU_RS11505 ^@ http://purl.uniprot.org/uniprot/C7NEF9 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/523794:LEBU_RS01855 ^@ http://purl.uniprot.org/uniprot/C7NE88 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523794:LEBU_RS10390 ^@ http://purl.uniprot.org/uniprot/C7ND68 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the YbaB/EbfC family.|||Binds to DNA and alters its conformation. May be involved in regulation of gene expression, nucleoid organization and DNA protection.|||Homodimer.|||nucleoid http://togogenome.org/gene/523794:LEBU_RS08625 ^@ http://purl.uniprot.org/uniprot/C7NBT5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09130 ^@ http://purl.uniprot.org/uniprot/C7NC33 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03915 ^@ http://purl.uniprot.org/uniprot/C7N954 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/523794:LEBU_RS10510 ^@ http://purl.uniprot.org/uniprot/C7ND89 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523794:LEBU_RS03965 ^@ http://purl.uniprot.org/uniprot/C7N964 ^@ Similarity ^@ Belongs to the BMP lipoprotein family. http://togogenome.org/gene/523794:LEBU_RS01070 ^@ http://purl.uniprot.org/uniprot/C7NDG7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/523794:LEBU_RS10660 ^@ http://purl.uniprot.org/uniprot/C7NDB7 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/523794:LEBU_RS04145 ^@ http://purl.uniprot.org/uniprot/C7N9A0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/523794:LEBU_RS04410 ^@ http://purl.uniprot.org/uniprot/C7N9F3 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/523794:LEBU_RS01230 ^@ http://purl.uniprot.org/uniprot/C7NDK1 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/523794:LEBU_RS09310 ^@ http://purl.uniprot.org/uniprot/C7NC64 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/523794:LEBU_RS02965 ^@ http://purl.uniprot.org/uniprot/C7N8L3 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/523794:LEBU_RS02625 ^@ http://purl.uniprot.org/uniprot/C7NER7 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/523794:LEBU_RS06515 ^@ http://purl.uniprot.org/uniprot/C7NAM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/523794:LEBU_RS03415 ^@ http://purl.uniprot.org/uniprot/C7N8V4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/523794:LEBU_RS08045 ^@ http://purl.uniprot.org/uniprot/C7NBH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS07900 ^@ http://purl.uniprot.org/uniprot/C7NBE3 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/523794:LEBU_RS11080 ^@ http://purl.uniprot.org/uniprot/C7NDV3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS07685 ^@ http://purl.uniprot.org/uniprot/C7NB99 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||In the C-terminal section; belongs to the GTP cyclohydrolase II family.|||In the N-terminal section; belongs to the DHBP synthase family. http://togogenome.org/gene/523794:LEBU_RS03770 ^@ http://purl.uniprot.org/uniprot/C7N925 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PEP-utilizing enzyme family.|||Cytoplasm|||General (non sugar-specific) component of the phosphoenolpyruvate-dependent sugar phosphotransferase system (sugar PTS). This major carbohydrate active-transport system catalyzes the phosphorylation of incoming sugar substrates concomitantly with their translocation across the cell membrane. Enzyme I transfers the phosphoryl group from phosphoenolpyruvate (PEP) to the phosphoryl carrier protein (HPr). http://togogenome.org/gene/523794:LEBU_RS04080 ^@ http://purl.uniprot.org/uniprot/C7N987 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS09370 ^@ http://purl.uniprot.org/uniprot/C7NC76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/523794:LEBU_RS07480 ^@ http://purl.uniprot.org/uniprot/C7NB57 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/523794:LEBU_RS10360 ^@ http://purl.uniprot.org/uniprot/C7ND67 ^@ Similarity ^@ Belongs to the IMPACT family. http://togogenome.org/gene/523794:LEBU_RS02840 ^@ http://purl.uniprot.org/uniprot/C7N8I7 ^@ Similarity ^@ Belongs to the CobT family. http://togogenome.org/gene/523794:LEBU_RS07325 ^@ http://purl.uniprot.org/uniprot/C7NB29 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/523794:LEBU_RS07650 ^@ http://purl.uniprot.org/uniprot/C7NB92 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS10185 ^@ http://purl.uniprot.org/uniprot/C7ND38 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/523794:LEBU_RS02170 ^@ http://purl.uniprot.org/uniprot/C7NEI2 ^@ Function|||Similarity|||Subunit ^@ Associates with the 50S ribosomal subunit.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.|||GTPase that plays an essential role in the late steps of ribosome biogenesis. http://togogenome.org/gene/523794:LEBU_RS00700 ^@ http://purl.uniprot.org/uniprot/C7NCZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase RlmH family.|||Cytoplasm|||Homodimer.|||Specifically methylates the pseudouridine at position 1915 (m3Psi1915) in 23S rRNA. http://togogenome.org/gene/523794:LEBU_RS08815 ^@ http://purl.uniprot.org/uniprot/C7NBX2 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/523794:LEBU_RS00395 ^@ http://purl.uniprot.org/uniprot/C7NCU3 ^@ Similarity ^@ Belongs to the bacterial microcompartments protein family. http://togogenome.org/gene/523794:LEBU_RS06270 ^@ http://purl.uniprot.org/uniprot/C7NAH6 ^@ Function|||Similarity ^@ Belongs to the sigma-70 factor family.|||Sigma factors are initiation factors that promote the attachment of RNA polymerase to specific initiation sites and are then released. http://togogenome.org/gene/523794:LEBU_RS10005 ^@ http://purl.uniprot.org/uniprot/C7NCN4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/523794:LEBU_RS00795 ^@ http://purl.uniprot.org/uniprot/C7ND15 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS02935 ^@ http://purl.uniprot.org/uniprot/C7N8K7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A 50S ribosomal subunit assembly protein with GTPase activity, required for 50S subunit assembly at low temperatures, may also play a role in translation. Binds GTP and analogs. Binds the 70S ribosome between the 30S and 50S subunits, in a similar position as ribosome-bound EF-G; it contacts a number of ribosomal proteins, both rRNAs and the A-site tRNA.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. BipA subfamily.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523794:LEBU_RS04185 ^@ http://purl.uniprot.org/uniprot/C7N9A8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05445 ^@ http://purl.uniprot.org/uniprot/C7NA12 ^@ Function|||Similarity ^@ Activation of anaerobic ribonucleoside-triphosphate reductase under anaerobic conditions by generation of an organic free radical, using S-adenosylmethionine and reduced flavodoxin as cosubstrates to produce 5'-deoxy-adenosine.|||Belongs to the organic radical-activating enzymes family. http://togogenome.org/gene/523794:LEBU_RS05240 ^@ http://purl.uniprot.org/uniprot/C7N9X0 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M3B family.|||Binds 1 zinc ion.|||Has oligopeptidase activity and degrades a variety of small bioactive peptides. http://togogenome.org/gene/523794:LEBU_RS01290 ^@ http://purl.uniprot.org/uniprot/C7NDL3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/523794:LEBU_RS07550 ^@ http://purl.uniprot.org/uniprot/C7NB71 ^@ Similarity ^@ Belongs to the disproportionating enzyme family. http://togogenome.org/gene/523794:LEBU_RS01935 ^@ http://purl.uniprot.org/uniprot/C7NEA3 ^@ Cofactor|||Similarity ^@ Belongs to the pyruvate:ferredoxin/flavodoxin oxidoreductase family.|||Binds 3 [4Fe-4S] clusters per subunit. http://togogenome.org/gene/523794:LEBU_RS00480 ^@ http://purl.uniprot.org/uniprot/C7NCV8 ^@ Function|||Similarity ^@ Belongs to the CbiD family.|||Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. http://togogenome.org/gene/523794:LEBU_RS09215 ^@ http://purl.uniprot.org/uniprot/C7NC44 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS11220 ^@ http://purl.uniprot.org/uniprot/C7NDY0 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523794:LEBU_RS02995 ^@ http://purl.uniprot.org/uniprot/C7N8L9 ^@ Activity Regulation|||Induction|||Similarity ^@ Belongs to the glycosyl hydrolase 1 family.|||Induced during growth on lactose or lactulose.|||Inhibited by both galactose-6-phosphate and ATP. http://togogenome.org/gene/523794:LEBU_RS01675 ^@ http://purl.uniprot.org/uniprot/C7NE51 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acetokinase family.|||Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction.|||Cytoplasm|||Homodimer.|||Mg(2+). Can also accept Mn(2+). http://togogenome.org/gene/523794:LEBU_RS10950 ^@ http://purl.uniprot.org/uniprot/C7NDT6 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05750 ^@ http://purl.uniprot.org/uniprot/C7NA74 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/523794:LEBU_RS10230 ^@ http://purl.uniprot.org/uniprot/C7ND47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsA/MreB family.|||Cytoplasm|||Forms membrane-associated dynamic filaments that are essential for cell shape determination. Acts by regulating cell wall synthesis and cell elongation, and thus cell shape. A feedback loop between cell geometry and MreB localization may maintain elongated cell shape by targeting cell wall growth to regions of negative cell wall curvature.|||Forms polymers. http://togogenome.org/gene/523794:LEBU_RS01295 ^@ http://purl.uniprot.org/uniprot/C7NDL4 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS5 family.|||Located at the back of the 30S subunit body where it stabilizes the conformation of the head with respect to the body.|||Part of the 30S ribosomal subunit. Contacts proteins S4 and S8.|||The N-terminal domain interacts with the head of the 30S subunit; the C-terminal domain interacts with the body and contacts protein S4. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S4 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523794:LEBU_RS03135 ^@ http://purl.uniprot.org/uniprot/C7N8P6 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/523794:LEBU_RS02155 ^@ http://purl.uniprot.org/uniprot/C7NEH9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS11290 ^@ http://purl.uniprot.org/uniprot/C7NDZ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 2 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS03550 ^@ http://purl.uniprot.org/uniprot/C7N8Y1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein 3 family.|||Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS02865 ^@ http://purl.uniprot.org/uniprot/C7N8J3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS11305 ^@ http://purl.uniprot.org/uniprot/C7NDZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09350 ^@ http://purl.uniprot.org/uniprot/C7NC72 ^@ Similarity ^@ Belongs to the RNA polymerase subunit omega family. http://togogenome.org/gene/523794:LEBU_RS07395 ^@ http://purl.uniprot.org/uniprot/C7NB41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 2 family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS09795 ^@ http://purl.uniprot.org/uniprot/C7NCJ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/523794:LEBU_RS09750 ^@ http://purl.uniprot.org/uniprot/C7NCI4 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/523794:LEBU_RS00705 ^@ http://purl.uniprot.org/uniprot/C7NCZ8 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family.|||This protein is involved in the repair of mismatches in DNA. It is required for dam-dependent methyl-directed DNA mismatch repair. May act as a 'molecular matchmaker', a protein that promotes the formation of a stable complex between two or more DNA-binding proteins in an ATP-dependent manner without itself being part of a final effector complex. http://togogenome.org/gene/523794:LEBU_RS00595 ^@ http://purl.uniprot.org/uniprot/C7NCY0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/523794:LEBU_RS08960 ^@ http://purl.uniprot.org/uniprot/C7NBZ8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DyP-type peroxidase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group non-covalently per subunit.|||Involved in the recovery of exogenous heme iron. Extracts iron from heme while preserving the protoporphyrin ring intact. http://togogenome.org/gene/523794:LEBU_RS06890 ^@ http://purl.uniprot.org/uniprot/C7NAU9 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/523794:LEBU_RS09580 ^@ http://purl.uniprot.org/uniprot/C7NCF0 ^@ Similarity ^@ Belongs to the asp23 family. http://togogenome.org/gene/523794:LEBU_RS02165 ^@ http://purl.uniprot.org/uniprot/C7NEI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the autoinducer-2 exporter (AI-2E) (TC 2.A.86) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS02610 ^@ http://purl.uniprot.org/uniprot/C7NER4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the vitamin-B12 independent methionine synthase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the transfer of a methyl group from 5-methyltetrahydrofolate to homocysteine resulting in methionine formation. http://togogenome.org/gene/523794:LEBU_RS01775 ^@ http://purl.uniprot.org/uniprot/C7NE72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS10960 ^@ http://purl.uniprot.org/uniprot/C7NDT8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 25 family. http://togogenome.org/gene/523794:LEBU_RS05395 ^@ http://purl.uniprot.org/uniprot/C7NA04 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endonuclease Cas1 family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain spacers, sequences complementary to antecedent mobile elements, and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Acts as a dsDNA endonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas2 homodimer. http://togogenome.org/gene/523794:LEBU_RS04040 ^@ http://purl.uniprot.org/uniprot/C7N979 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS02645 ^@ http://purl.uniprot.org/uniprot/C7NES1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS05740 ^@ http://purl.uniprot.org/uniprot/C7NA72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the auxin efflux carrier (TC 2.A.69) family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS03990 ^@ http://purl.uniprot.org/uniprot/C7N969 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell inner membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/523794:LEBU_RS01205 ^@ http://purl.uniprot.org/uniprot/C7NDJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS01045 ^@ http://purl.uniprot.org/uniprot/C7NDG2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS10955 ^@ http://purl.uniprot.org/uniprot/C7NDT7 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/523794:LEBU_RS11410 ^@ http://purl.uniprot.org/uniprot/C7NEE0 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphoenolpyruvate carboxykinase (ATP) family.|||Binds 1 Mn(2+) ion per subunit.|||Cytoplasm|||Involved in the gluconeogenesis. Catalyzes the conversion of oxaloacetate (OAA) to phosphoenolpyruvate (PEP) through direct phosphoryl transfer between the nucleoside triphosphate and OAA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09155 ^@ http://purl.uniprot.org/uniprot/C7NC38 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS02310 ^@ http://purl.uniprot.org/uniprot/C7NEK5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS01030 ^@ http://purl.uniprot.org/uniprot/C7NDF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/523794:LEBU_RS08850 ^@ http://purl.uniprot.org/uniprot/C7NBX9 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/523794:LEBU_RS00140 ^@ http://purl.uniprot.org/uniprot/C7NCC3 ^@ Similarity ^@ Belongs to the precorrin methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS06280 ^@ http://purl.uniprot.org/uniprot/C7NAH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PlsY family.|||Catalyzes the transfer of an acyl group from acyl-phosphate (acyl-PO(4)) to glycerol-3-phosphate (G3P) to form lysophosphatidic acid (LPA). This enzyme utilizes acyl-phosphate as fatty acyl donor, but not acyl-CoA or acyl-ACP.|||Cell inner membrane|||Probably interacts with PlsX. http://togogenome.org/gene/523794:LEBU_RS10965 ^@ http://purl.uniprot.org/uniprot/C7NDT9 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS04850 ^@ http://purl.uniprot.org/uniprot/C7N9N9 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/523794:LEBU_RS10975 ^@ http://purl.uniprot.org/uniprot/C7NDU1 ^@ Function|||Similarity ^@ Belongs to the LpxK family.|||Transfers the gamma-phosphate of ATP to the 4'-position of a tetraacyldisaccharide 1-phosphate intermediate (termed DS-1-P) to form tetraacyldisaccharide 1,4'-bis-phosphate (lipid IVA). http://togogenome.org/gene/523794:LEBU_RS02875 ^@ http://purl.uniprot.org/uniprot/C7N8J5 ^@ Function|||Similarity ^@ Belongs to the carbohydrate kinase PfkB family.|||Catalyzes the ATP-dependent phosphorylation of fructose-l-phosphate to fructose-l,6-bisphosphate. http://togogenome.org/gene/523794:LEBU_RS01060 ^@ http://purl.uniprot.org/uniprot/C7NDG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS01325 ^@ http://purl.uniprot.org/uniprot/C7NDM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS06535 ^@ http://purl.uniprot.org/uniprot/C7NAM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromate ion transporter (CHR) (TC 2.A.51) family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09950 ^@ http://purl.uniprot.org/uniprot/C7NCM3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/523794:LEBU_RS08670 ^@ http://purl.uniprot.org/uniprot/C7NBU4 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/523794:LEBU_RS11075 ^@ http://purl.uniprot.org/uniprot/C7NDV2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS02385 ^@ http://purl.uniprot.org/uniprot/C7NEL9 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/523794:LEBU_RS09330 ^@ http://purl.uniprot.org/uniprot/C7NC68 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/523794:LEBU_RS11480 ^@ http://purl.uniprot.org/uniprot/C7NEF4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/523794:LEBU_RS02060 ^@ http://purl.uniprot.org/uniprot/C7NEC7 ^@ Similarity|||Subunit ^@ Belongs to the UPF0210 family.|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS05095 ^@ http://purl.uniprot.org/uniprot/C7N9U1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS09850 ^@ http://purl.uniprot.org/uniprot/C7NCK4 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/523794:LEBU_RS01055 ^@ http://purl.uniprot.org/uniprot/C7NDG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS04055 ^@ http://purl.uniprot.org/uniprot/C7N982 ^@ Similarity ^@ Belongs to the DNA polymerase type-A family. http://togogenome.org/gene/523794:LEBU_RS05715 ^@ http://purl.uniprot.org/uniprot/C7NA67 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MscL family.|||Cell inner membrane|||Channel that opens in response to stretch forces in the membrane lipid bilayer. May participate in the regulation of osmotic pressure changes within the cell.|||Homopentamer.|||Membrane http://togogenome.org/gene/523794:LEBU_RS07620 ^@ http://purl.uniprot.org/uniprot/C7NB86 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09505 ^@ http://purl.uniprot.org/uniprot/C7NCD6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/523794:LEBU_RS08220 ^@ http://purl.uniprot.org/uniprot/C7NBK6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS00845 ^@ http://purl.uniprot.org/uniprot/C7NDD2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/523794:LEBU_RS01285 ^@ http://purl.uniprot.org/uniprot/C7NDL2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/523794:LEBU_RS04930 ^@ http://purl.uniprot.org/uniprot/C7N9Q7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS09105 ^@ http://purl.uniprot.org/uniprot/C7NC28 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acetyl-CoA carboxylase is a heterohexamer composed of biotin carboxyl carrier protein (AccB), biotin carboxylase (AccC) and two subunits each of ACCase subunit alpha (AccA) and ACCase subunit beta (AccD).|||Belongs to the AccD/PCCB family.|||Binds 1 zinc ion per subunit.|||Component of the acetyl coenzyme A carboxylase (ACC) complex. Biotin carboxylase (BC) catalyzes the carboxylation of biotin on its carrier protein (BCCP) and then the CO(2) group is transferred by the transcarboxylase to acetyl-CoA to form malonyl-CoA.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS06335 ^@ http://purl.uniprot.org/uniprot/C7NAI9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/523794:LEBU_RS03830 ^@ http://purl.uniprot.org/uniprot/C7N937 ^@ Function|||Similarity ^@ Belongs to the V-ATPase D subunit family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. http://togogenome.org/gene/523794:LEBU_RS02480 ^@ http://purl.uniprot.org/uniprot/C7NEN8 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/523794:LEBU_RS04225 ^@ http://purl.uniprot.org/uniprot/C7N9B6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS07530 ^@ http://purl.uniprot.org/uniprot/C7NB67 ^@ Cofactor|||Function|||Induction|||Similarity|||Subunit ^@ Belongs to the glycosyl hydrolase 4 family.|||Binds 1 Mn(2+) ion per subunit.|||Binds 1 NAD(+) per subunit.|||Homodimer.|||In vitro, readily hydrolyzes p-nitrophenyl-alpha-D-glucopyranoside 6-phosphate (pNPalphaG6P), a chromogenic analog of the phosphorylated isomers of sucrose. In vivo, is probably involved in the degradation of the 6-phosphate derivatives of the sucrose isomers trehalulose, turanose, maltulose and palatinose, catalyzing their hydrolysis into glucose 6-phosphate (G6P) and fructose, which allows the bacterium to use these sugars as energy sources for growth. Is not able to hydrolyze the C2 or C4 chromogenic stereomers (i.e. pNPalpha-mannopyranoside-6P and pNPalpha-galactopyranoside-6P, respectively).|||Induced by growth on the sucrose isomers trehalulose, turanose, maltulose and palatinose. http://togogenome.org/gene/523794:LEBU_RS08745 ^@ http://purl.uniprot.org/uniprot/C7NBV8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HSP33 family.|||Cytoplasm|||Redox regulated molecular chaperone. Protects both thermally unfolding and oxidatively damaged proteins from irreversible aggregation. Plays an important role in the bacterial defense system toward oxidative stress.|||Under oxidizing conditions two disulfide bonds are formed involving the reactive cysteines. Under reducing conditions zinc is bound to the reactive cysteines and the protein is inactive. http://togogenome.org/gene/523794:LEBU_RS01925 ^@ http://purl.uniprot.org/uniprot/C7NEA1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the ABC transporter complex (TC 3.A.1.6.1) involved in sulfate/thiosulfate import.|||Part of the ABC transporter complex CysAWTP (TC 3.A.1.6.1) involved in sulfate/thiosulfate import. Probably responsible for the translocation of the substrate across the membrane.|||The complex is composed of two ATP-binding proteins (CysA), two transmembrane proteins (CysT and CysW) and a solute-binding protein (CysP). http://togogenome.org/gene/523794:LEBU_RS06035 ^@ http://purl.uniprot.org/uniprot/C7NAC9 ^@ Similarity|||Subcellular Location Annotation ^@ Cytoplasm|||In the C-terminal section; belongs to the PRA-PH family.|||In the N-terminal section; belongs to the PRA-CH family. http://togogenome.org/gene/523794:LEBU_RS01250 ^@ http://purl.uniprot.org/uniprot/C7NDK5 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/523794:LEBU_RS05775 ^@ http://purl.uniprot.org/uniprot/C7NA79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NlpA lipoprotein family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS00565 ^@ http://purl.uniprot.org/uniprot/C7NCX4 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS11415 ^@ http://purl.uniprot.org/uniprot/C7NEE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gmhB family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS05390 ^@ http://purl.uniprot.org/uniprot/C7NA03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/523794:LEBU_RS03230 ^@ http://purl.uniprot.org/uniprot/C7N8R5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS03300 ^@ http://purl.uniprot.org/uniprot/C7N8S9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DapB family.|||Catalyzes the conversion of 4-hydroxy-tetrahydrodipicolinate (HTPA) to tetrahydrodipicolinate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Was originally thought to be a dihydrodipicolinate reductase (DHDPR), catalyzing the conversion of dihydrodipicolinate to tetrahydrodipicolinate. However, it was shown in E.coli that the substrate of the enzymatic reaction is not dihydrodipicolinate (DHDP) but in fact (2S,4S)-4-hydroxy-2,3,4,5-tetrahydrodipicolinic acid (HTPA), the product released by the DapA-catalyzed reaction. http://togogenome.org/gene/523794:LEBU_RS07590 ^@ http://purl.uniprot.org/uniprot/C7NB81 ^@ Similarity ^@ Belongs to the ArsC family. http://togogenome.org/gene/523794:LEBU_RS07505 ^@ http://purl.uniprot.org/uniprot/C7NB62 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/523794:LEBU_RS11225 ^@ http://purl.uniprot.org/uniprot/C7NDY1 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/523794:LEBU_RS11120 ^@ http://purl.uniprot.org/uniprot/C7NDW1 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/523794:LEBU_RS02080 ^@ http://purl.uniprot.org/uniprot/C7NED0 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/523794:LEBU_RS04335 ^@ http://purl.uniprot.org/uniprot/C7N9D8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09985 ^@ http://purl.uniprot.org/uniprot/C7NCN0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferritin family. Prokaryotic subfamily.|||Cytoplasm|||Iron-storage protein. http://togogenome.org/gene/523794:LEBU_RS07565 ^@ http://purl.uniprot.org/uniprot/C7NB76 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/523794:LEBU_RS01615 ^@ http://purl.uniprot.org/uniprot/C7NE40 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08350 ^@ http://purl.uniprot.org/uniprot/C7NBN2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS01305 ^@ http://purl.uniprot.org/uniprot/C7NDL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL15 family.|||Binds to the 23S rRNA.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/523794:LEBU_RS03455 ^@ http://purl.uniprot.org/uniprot/C7N8W2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2B subfamily.|||Cytoplasm|||Homodimer.|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS04320 ^@ http://purl.uniprot.org/uniprot/C7N9D5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/523794:LEBU_RS01665 ^@ http://purl.uniprot.org/uniprot/C7NE49 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. FtsY subfamily.|||Cell inner membrane|||Cytoplasm|||Involved in targeting and insertion of nascent membrane proteins into the cytoplasmic membrane. Acts as a receptor for the complex formed by the signal recognition particle (SRP) and the ribosome-nascent chain (RNC).|||Membrane|||Part of the signal recognition particle protein translocation system, which is composed of SRP and FtsY. http://togogenome.org/gene/523794:LEBU_RS09955 ^@ http://purl.uniprot.org/uniprot/C7NCM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/523794:LEBU_RS04395 ^@ http://purl.uniprot.org/uniprot/C7N9F0 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by ADP and other diphosphonucleosides, and allosterically inhibited by phosphoenolpyruvate.|||Belongs to the phosphofructokinase type A (PFKA) family. ATP-dependent PFK group I subfamily. Prokaryotic clade 'B1' sub-subfamily.|||Catalyzes the phosphorylation of D-fructose 6-phosphate to fructose 1,6-bisphosphate by ATP, the first committing step of glycolysis.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09550 ^@ http://purl.uniprot.org/uniprot/C7NCE4 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/523794:LEBU_RS00270 ^@ http://purl.uniprot.org/uniprot/C7NCR9 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/523794:LEBU_RS09145 ^@ http://purl.uniprot.org/uniprot/C7NC36 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell inner membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/523794:LEBU_RS06725 ^@ http://purl.uniprot.org/uniprot/C7NAR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/523794:LEBU_RS09260 ^@ http://purl.uniprot.org/uniprot/C7NC53 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS10565 ^@ http://purl.uniprot.org/uniprot/C7NDA1 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/523794:LEBU_RS03470 ^@ http://purl.uniprot.org/uniprot/C7N8W5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/523794:LEBU_RS01835 ^@ http://purl.uniprot.org/uniprot/C7NE84 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A8 family.|||Cell inner membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This protein specifically catalyzes the removal of signal peptides from prolipoproteins. http://togogenome.org/gene/523794:LEBU_RS08405 ^@ http://purl.uniprot.org/uniprot/C7NBP2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03800 ^@ http://purl.uniprot.org/uniprot/C7N931 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS00475 ^@ http://purl.uniprot.org/uniprot/C7NCV7 ^@ Similarity ^@ Belongs to the CobH/CbiC family. http://togogenome.org/gene/523794:LEBU_RS01765 ^@ http://purl.uniprot.org/uniprot/C7NE70 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/523794:LEBU_RS03375 ^@ http://purl.uniprot.org/uniprot/C7N8U6 ^@ Similarity ^@ Belongs to the prolyl-tRNA editing family. YbaK/EbsC subfamily. http://togogenome.org/gene/523794:LEBU_RS11360 ^@ http://purl.uniprot.org/uniprot/C7NE08 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site.|||Cytoplasm|||In the C-terminal section; belongs to the helicase family. RecG subfamily.|||In the N-terminal section; belongs to the UvrB family. http://togogenome.org/gene/523794:LEBU_RS11475 ^@ http://purl.uniprot.org/uniprot/C7NEF3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS03290 ^@ http://purl.uniprot.org/uniprot/C7N8S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0410 family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS02195 ^@ http://purl.uniprot.org/uniprot/C7NEI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS06050 ^@ http://purl.uniprot.org/uniprot/C7NAD2 ^@ Similarity ^@ Belongs to the phD/YefM antitoxin family. http://togogenome.org/gene/523794:LEBU_RS02715 ^@ http://purl.uniprot.org/uniprot/C7N8G5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/523794:LEBU_RS10650 ^@ http://purl.uniprot.org/uniprot/C7NDB5 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/523794:LEBU_RS02755 ^@ http://purl.uniprot.org/uniprot/C7N8H3 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/523794:LEBU_RS11450 ^@ http://purl.uniprot.org/uniprot/C7NEE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS10760 ^@ http://purl.uniprot.org/uniprot/C7NDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GtrA family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09385 ^@ http://purl.uniprot.org/uniprot/C7NC79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/523794:LEBU_RS02670 ^@ http://purl.uniprot.org/uniprot/C7NES6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exbB/tolQ family.|||Membrane http://togogenome.org/gene/523794:LEBU_RS06500 ^@ http://purl.uniprot.org/uniprot/C7NAM1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FKBP-type PPIase family. Tig subfamily.|||Consists of 3 domains; the N-terminus binds the ribosome, the middle domain has PPIase activity, while the C-terminus has intrinsic chaperone activity on its own.|||Cytoplasm|||Involved in protein export. Acts as a chaperone by maintaining the newly synthesized protein in an open conformation. Functions as a peptidyl-prolyl cis-trans isomerase. http://togogenome.org/gene/523794:LEBU_RS05770 ^@ http://purl.uniprot.org/uniprot/C7NA78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS00260 ^@ http://purl.uniprot.org/uniprot/C7NCR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CobS family.|||Cell inner membrane|||Joins adenosylcobinamide-GDP and alpha-ribazole to generate adenosylcobalamin (Ado-cobalamin). Also synthesizes adenosylcobalamin 5'-phosphate from adenosylcobinamide-GDP and alpha-ribazole 5'-phosphate.|||Membrane http://togogenome.org/gene/523794:LEBU_RS00720 ^@ http://purl.uniprot.org/uniprot/C7ND01 ^@ Similarity ^@ Belongs to the diphosphomevalonate decarboxylase family. http://togogenome.org/gene/523794:LEBU_RS03265 ^@ http://purl.uniprot.org/uniprot/C7N8S2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase alpha/beta chains family.|||Cell inner membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a(1), b(2) and c(9-12). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. CF(1) is attached to CF(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/523794:LEBU_RS02215 ^@ http://purl.uniprot.org/uniprot/C7NEJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS03825 ^@ http://purl.uniprot.org/uniprot/C7N936 ^@ Function|||Similarity ^@ Belongs to the ATPase alpha/beta chains family.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The V-type beta chain is a regulatory subunit. http://togogenome.org/gene/523794:LEBU_RS07420 ^@ http://purl.uniprot.org/uniprot/C7NB46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/523794:LEBU_RS10160 ^@ http://purl.uniprot.org/uniprot/C7ND32 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS09280 ^@ http://purl.uniprot.org/uniprot/C7NC58 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/523794:LEBU_RS05875 ^@ http://purl.uniprot.org/uniprot/C7NA98 ^@ Similarity ^@ Belongs to the UDPGP type 2 family. http://togogenome.org/gene/523794:LEBU_RS02405 ^@ http://purl.uniprot.org/uniprot/C7NEM3 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/523794:LEBU_RS08885 ^@ http://purl.uniprot.org/uniprot/C7NBY6 ^@ Similarity ^@ Belongs to the HicA mRNA interferase family. http://togogenome.org/gene/523794:LEBU_RS06285 ^@ http://purl.uniprot.org/uniprot/C7NAH9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family. MepA subfamily.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS06265 ^@ http://purl.uniprot.org/uniprot/C7NAH5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/523794:LEBU_RS05510 ^@ http://purl.uniprot.org/uniprot/C7NA27 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/523794:LEBU_RS09605 ^@ http://purl.uniprot.org/uniprot/C7NCF5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.|||Binds 2 [4Fe-4S] clusters per subunit.|||Cell inner membrane|||Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.|||The complex is composed of six subunits: RnfA, RnfB, RnfC, RnfD, RnfE and RnfG. http://togogenome.org/gene/523794:LEBU_RS06105 ^@ http://purl.uniprot.org/uniprot/C7NAE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS07415 ^@ http://purl.uniprot.org/uniprot/C7NB45 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/523794:LEBU_RS01050 ^@ http://purl.uniprot.org/uniprot/C7NDG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell inner membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS00470 ^@ http://purl.uniprot.org/uniprot/C7NCV6 ^@ Domain|||Function|||Miscellaneous|||Similarity ^@ Belongs to the CobB/CbiA family.|||Catalyzes the ATP-dependent amidation of the two carboxylate groups at positions a and c of cobyrinate, using either L-glutamine or ammonia as the nitrogen source.|||Comprises of two domains. The C-terminal domain contains the binding site for glutamine and catalyzes the hydrolysis of this substrate to glutamate and ammonia. The N-terminal domain is anticipated to bind ATP and cobyrinate and catalyzes the ultimate synthesis of the diamide product. The ammonia produced via the glutaminase domain is probably translocated to the adjacent domain via a molecular tunnel, where it reacts with an activated intermediate.|||The a and c carboxylates of cobyrinate are activated for nucleophilic attack via formation of a phosphorylated intermediate by ATP. CbiA catalyzes first the amidation of the c-carboxylate, and then that of the a-carboxylate. http://togogenome.org/gene/523794:LEBU_RS06290 ^@ http://purl.uniprot.org/uniprot/C7NAI0 ^@ Function ^@ Condensation of UDP-2,3-diacylglucosamine and 2,3-diacylglucosamine-1-phosphate to form lipid A disaccharide, a precursor of lipid A, a phosphorylated glycolipid that anchors the lipopolysaccharide to the outer membrane of the cell. http://togogenome.org/gene/523794:LEBU_RS09565 ^@ http://purl.uniprot.org/uniprot/C7NCE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS03220 ^@ http://purl.uniprot.org/uniprot/C7N8R3 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. ArgD subfamily.|||Binds 1 pyridoxal phosphate per subunit.|||Cytoplasm|||Homodimer.|||May also have succinyldiaminopimelate aminotransferase activity, thus carrying out the corresponding step in lysine biosynthesis. http://togogenome.org/gene/523794:LEBU_RS01825 ^@ http://purl.uniprot.org/uniprot/C7NE82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lactate permease family.|||Cell membrane|||Membrane|||Uptake of L-lactate across the membrane. Can also transport D-lactate and glycolate. http://togogenome.org/gene/523794:LEBU_RS02375 ^@ http://purl.uniprot.org/uniprot/C7NEL7 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/523794:LEBU_RS03855 ^@ http://purl.uniprot.org/uniprot/C7N942 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/523794:LEBU_RS11140 ^@ http://purl.uniprot.org/uniprot/C7NDW5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/523794:LEBU_RS08800 ^@ http://purl.uniprot.org/uniprot/C7NBW9 ^@ Similarity ^@ Belongs to the NAD synthetase family. http://togogenome.org/gene/523794:LEBU_RS10845 ^@ http://purl.uniprot.org/uniprot/C7NDR5 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523794:LEBU_RS06210 ^@ http://purl.uniprot.org/uniprot/C7NAG3 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/523794:LEBU_RS06215 ^@ http://purl.uniprot.org/uniprot/C7NAG4 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M48 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/523794:LEBU_RS03425 ^@ http://purl.uniprot.org/uniprot/C7N8V6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/523794:LEBU_RS07830 ^@ http://purl.uniprot.org/uniprot/C7NBC9 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/523794:LEBU_RS05735 ^@ http://purl.uniprot.org/uniprot/C7NA71 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS09360 ^@ http://purl.uniprot.org/uniprot/C7NC74 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/523794:LEBU_RS04835 ^@ http://purl.uniprot.org/uniprot/C7N9N6 ^@ Similarity ^@ Belongs to the TrbE/VirB4 family. http://togogenome.org/gene/523794:LEBU_RS07110 ^@ http://purl.uniprot.org/uniprot/C7NAY8 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA M5U methyltransferase family. http://togogenome.org/gene/523794:LEBU_RS06135 ^@ http://purl.uniprot.org/uniprot/C7NAE7 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the histidinol dehydrogenase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the sequential NAD-dependent oxidations of L-histidinol to L-histidinaldehyde and then to L-histidine. http://togogenome.org/gene/523794:LEBU_RS10115 ^@ http://purl.uniprot.org/uniprot/C7ND23 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS05225 ^@ http://purl.uniprot.org/uniprot/C7N9W7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS09255 ^@ http://purl.uniprot.org/uniprot/C7NC52 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/523794:LEBU_RS11490 ^@ http://purl.uniprot.org/uniprot/C7NEF6 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. YfcE family. http://togogenome.org/gene/523794:LEBU_RS09450 ^@ http://purl.uniprot.org/uniprot/C7NC91 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 32 family.|||Cytoplasm|||Enables the bacterium to metabolize sucrose as a sole carbon source. http://togogenome.org/gene/523794:LEBU_RS09480 ^@ http://purl.uniprot.org/uniprot/C7NCD2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycyl radical enzyme (GRE) family. PFL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS00145 ^@ http://purl.uniprot.org/uniprot/C7NCC4 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/523794:LEBU_RS06420 ^@ http://purl.uniprot.org/uniprot/C7NAK6 ^@ Similarity ^@ Belongs to the 4-hydroxybenzoyl-CoA thioesterase family. http://togogenome.org/gene/523794:LEBU_RS03995 ^@ http://purl.uniprot.org/uniprot/C7N970 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CRISPR-associated endoribonuclease Cas2 protein family.|||CRISPR (clustered regularly interspaced short palindromic repeat), is an adaptive immune system that provides protection against mobile genetic elements (viruses, transposable elements and conjugative plasmids). CRISPR clusters contain sequences complementary to antecedent mobile elements and target invading nucleic acids. CRISPR clusters are transcribed and processed into CRISPR RNA (crRNA). Functions as a ssRNA-specific endoribonuclease. Involved in the integration of spacer DNA into the CRISPR cassette.|||Homodimer, forms a heterotetramer with a Cas1 homodimer. http://togogenome.org/gene/523794:LEBU_RS00050 ^@ http://purl.uniprot.org/uniprot/C7NCA4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MnmG family.|||Cytoplasm|||Homodimer. Heterotetramer of two MnmE and two MnmG subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NAD-binding protein involved in the addition of a carboxymethylaminomethyl (cmnm) group at the wobble position (U34) of certain tRNAs, forming tRNA-cmnm(5)s(2)U34. http://togogenome.org/gene/523794:LEBU_RS09940 ^@ http://purl.uniprot.org/uniprot/C7NCM1 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL36 family. http://togogenome.org/gene/523794:LEBU_RS03245 ^@ http://purl.uniprot.org/uniprot/C7N8R8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase C chain family.|||Cell inner membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/523794:LEBU_RS09990 ^@ http://purl.uniprot.org/uniprot/C7NCN1 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/523794:LEBU_RS05060 ^@ http://purl.uniprot.org/uniprot/C7N9T4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/523794:LEBU_RS02655 ^@ http://purl.uniprot.org/uniprot/C7NES3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MnmA/TRMU family.|||Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s(2)U34.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/523794:LEBU_RS03495 ^@ http://purl.uniprot.org/uniprot/C7N8X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. PrmA family.|||Cytoplasm|||Methylates ribosomal protein L11. http://togogenome.org/gene/523794:LEBU_RS09120 ^@ http://purl.uniprot.org/uniprot/C7NC31 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/523794:LEBU_RS09125 ^@ http://purl.uniprot.org/uniprot/C7NC32 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS05470 ^@ http://purl.uniprot.org/uniprot/C7NA19 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/523794:LEBU_RS10400 ^@ http://purl.uniprot.org/uniprot/C7ND70 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/523794:LEBU_RS03095 ^@ http://purl.uniprot.org/uniprot/C7N8N8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/523794:LEBU_RS00060 ^@ http://purl.uniprot.org/uniprot/C7NCA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. FecCD subfamily.|||Membrane http://togogenome.org/gene/523794:LEBU_RS05915 ^@ http://purl.uniprot.org/uniprot/C7NAA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell inner membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/523794:LEBU_RS02675 ^@ http://purl.uniprot.org/uniprot/C7NES7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ExbD/TolR family.|||Cell membrane http://togogenome.org/gene/523794:LEBU_RS10170 ^@ http://purl.uniprot.org/uniprot/C7ND35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Activates KDO (a required 8-carbon sugar) for incorporation into bacterial lipopolysaccharide in Gram-negative bacteria.|||Belongs to the KdsB family.|||Cytoplasm http://togogenome.org/gene/523794:LEBU_RS06000 ^@ http://purl.uniprot.org/uniprot/C7NAC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurJ/MviN family.|||Cell inner membrane|||Involved in peptidoglycan biosynthesis. Transports lipid-linked peptidoglycan precursors from the inner to the outer leaflet of the cytoplasmic membrane.|||Membrane http://togogenome.org/gene/523794:LEBU_RS01115 ^@ http://purl.uniprot.org/uniprot/C7NDH6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/523794:LEBU_RS08595 ^@ http://purl.uniprot.org/uniprot/C7NBS9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/523794:LEBU_RS00455 ^@ http://purl.uniprot.org/uniprot/C7NCV3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CbiN family.|||Cell inner membrane|||Forms an energy-coupling factor (ECF) transporter complex composed of an ATP-binding protein (A component, CbiO), a transmembrane protein (T component, CbiQ) and 2 possible substrate-capture proteins (S components, CbiM and CbiN) of unknown stoichimetry.|||Part of the energy-coupling factor (ECF) transporter complex CbiMNOQ involved in cobalt import. http://togogenome.org/gene/523794:LEBU_RS01670 ^@ http://purl.uniprot.org/uniprot/C7NE50 ^@ Similarity ^@ Belongs to the phosphate acetyltransferase and butyryltransferase family. http://togogenome.org/gene/523794:LEBU_RS06705 ^@ http://purl.uniprot.org/uniprot/C7NAR2 ^@ Similarity ^@ Belongs to the peptidase M18 family. http://togogenome.org/gene/523794:LEBU_RS05610 ^@ http://purl.uniprot.org/uniprot/C7NA47 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/523794:LEBU_RS09355 ^@ http://purl.uniprot.org/uniprot/C7NC73 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylate kinase family.|||Cytoplasm|||Essential for recycling GMP and indirectly, cGMP. http://togogenome.org/gene/523794:LEBU_RS02400 ^@ http://purl.uniprot.org/uniprot/C7NEM2 ^@ Function|||Similarity ^@ Belongs to the CobU/CobP family.|||Catalyzes ATP-dependent phosphorylation of adenosylcobinamide and addition of GMP to adenosylcobinamide phosphate. http://togogenome.org/gene/523794:LEBU_RS00880 ^@ http://purl.uniprot.org/uniprot/C7NDD9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/523794:LEBU_RS11430 ^@ http://purl.uniprot.org/uniprot/C7NEE4 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 5 family. http://togogenome.org/gene/523794:LEBU_RS00940 ^@ http://purl.uniprot.org/uniprot/C7NDE8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 1 family. http://togogenome.org/gene/523794:LEBU_RS07610 ^@ http://purl.uniprot.org/uniprot/C7NB84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell inner membrane|||Cytoplasm|||Monomer.