http://togogenome.org/gene/535712:A4Z71_RS00130 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXE1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04300 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZF1 ^@ Similarity ^@ Belongs to the pseudouridine synthase RsuA family. http://togogenome.org/gene/535712:A4Z71_RS00650 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM8 ^@ Similarity|||Subunit ^@ Belongs to the GTP cyclohydrolase I family.|||Homopolymer. http://togogenome.org/gene/535712:A4Z71_RS00850 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR4 ^@ Similarity ^@ Belongs to the ferredoxin--NADP reductase type 1 family. http://togogenome.org/gene/535712:A4Z71_RS03545 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ14 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.|||Binds 2 Zn(2+) ions per subunit.|||Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02900 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03520 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ13 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type-II 3-dehydroquinase family.|||Catalyzes a trans-dehydration via an enolate intermediate.|||Homododecamer. http://togogenome.org/gene/535712:A4Z71_RS04660 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NusA family.|||Cytoplasm|||Monomer. Binds directly to the core enzyme of the DNA-dependent RNA polymerase and to nascent RNA.|||Participates in both transcription termination and antitermination. http://togogenome.org/gene/535712:A4Z71_RS06040 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A5 ^@ Similarity ^@ Belongs to the pirin family. http://togogenome.org/gene/535712:A4Z71_RS01120 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS02925 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Cell membrane|||Required for accurate and efficient protein synthesis under certain stress conditions. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Back-translocation proceeds from a post-translocation (POST) complex to a pre-translocation (PRE) complex, thus giving elongation factor G a second chance to translocate the tRNAs correctly. Binds to ribosomes in a GTP-dependent manner. http://togogenome.org/gene/535712:A4Z71_RS02730 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYP2 ^@ Function|||Similarity|||Subunit ^@ ATP-dependent specificity component of the Clp protease. It directs the protease to specific substrates. Can perform chaperone functions in the absence of ClpP.|||Belongs to the ClpX chaperone family.|||Component of the ClpX-ClpP complex. Forms a hexameric ring that, in the presence of ATP, binds to fourteen ClpP subunits assembled into a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/535712:A4Z71_RS03490 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YqgF HJR family.|||Could be a nuclease involved in processing of the 5'-end of pre-16S rRNA.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05345 ^@ http://purl.uniprot.org/uniprot/A0A1D9E005 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/535712:A4Z71_RS02685 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0X8 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/535712:A4Z71_RS00590 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS00160 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXE4 ^@ Function|||Induction|||Similarity ^@ Acts as a chaperone.|||Belongs to the heat shock protein 70 family.|||By stress conditions e.g. heat shock. http://togogenome.org/gene/535712:A4Z71_RS03675 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ55 ^@ Similarity|||Subunit ^@ Belongs to the pyruvate kinase family.|||Homotetramer. http://togogenome.org/gene/535712:A4Z71_RS01310 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0U8 ^@ Caution|||Function|||PTM|||Similarity ^@ Acetylated. Deacetylation by the SIR2-homolog deacetylase activates the enzyme.|||Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. AcsA undergoes a two-step reaction. In the first half reaction, AcsA combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05120 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZV2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 2 subfamily.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit.|||Catalyzes the oxidation of 3-carboxy-2-hydroxy-4-methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2-oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS01860 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY88 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS04285 ^@ http://purl.uniprot.org/uniprot/A0A1D9E103 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytidylate kinase family. Type 1 subfamily.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05195 ^@ http://purl.uniprot.org/uniprot/A0A1D9E002 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04955 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT9 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/535712:A4Z71_RS04575 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP0 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/535712:A4Z71_RS02975 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.|||Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Era GTPase family.|||Cell membrane|||Cytoplasm|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS00195 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXF1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS06800 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0P7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS02490 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYK9 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/535712:A4Z71_RS02930 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||Cytoplasm|||Probably acts as a heme chaperone, transferring heme to an unknown acceptor. Binds one molecule of heme per monomer, possibly covalently. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine. http://togogenome.org/gene/535712:A4Z71_RS06915 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0T4 ^@ Similarity ^@ Belongs to the thioredoxin family. http://togogenome.org/gene/535712:A4Z71_RS03585 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ29 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit.|||Binds 2 divalent ions per subunit.|||Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.|||Cytoplasm|||Homotetramer; dimer of dimers. http://togogenome.org/gene/535712:A4Z71_RS04825 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Homoserine kinase subfamily.|||Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04400 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAGSA dehydrogenase family. Type 1 subfamily.|||Catalyzes the NADPH-dependent reduction of N-acetyl-5-glutamyl phosphate to yield N-acetyl-L-glutamate 5-semialdehyde.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06515 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0J7 ^@ Domain|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the glutamyl-tRNA reductase family.|||Catalyzes the NADPH-dependent reduction of glutamyl-tRNA(Glu) to glutamate 1-semialdehyde (GSA).|||During catalysis, the active site Cys acts as a nucleophile attacking the alpha-carbonyl group of tRNA-bound glutamate with the formation of a thioester intermediate between enzyme and glutamate, and the concomitant release of tRNA(Glu). The thioester intermediate is finally reduced by direct hydride transfer from NADPH, to form the product GSA.|||Homodimer.|||Possesses an unusual extended V-shaped dimeric structure with each monomer consisting of three distinct domains arranged along a curved 'spinal' alpha-helix. The N-terminal catalytic domain specifically recognizes the glutamate moiety of the substrate. The second domain is the NADPH-binding domain, and the third C-terminal domain is responsible for dimerization. http://togogenome.org/gene/535712:A4Z71_RS01995 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB0 ^@ Function|||Similarity ^@ Belongs to the RmuC family.|||Involved in DNA recombination. http://togogenome.org/gene/535712:A4Z71_RS01410 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY13 ^@ Similarity ^@ Belongs to the peptidase S13 family. http://togogenome.org/gene/535712:A4Z71_RS00855 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXS0 ^@ Similarity ^@ Belongs to the glycosyl hydrolase. http://togogenome.org/gene/535712:A4Z71_RS05585 ^@ http://purl.uniprot.org/uniprot/A0A1D9E055 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the DHBP synthase family.|||Belongs to the GTP cyclohydrolase II family.|||Binds 1 zinc ion per subunit.|||Binds 2 divalent metal cations per subunit. Magnesium or manganese.|||Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate.|||Catalyzes the conversion of GTP to 2,5-diamino-6-ribosylamino-4(3H)-pyrimidinone 5'-phosphate (DARP), formate and pyrophosphate.|||Homodimer.|||In the N-terminal section; belongs to the DHBP synthase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS06070 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0E2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/535712:A4Z71_RS00940 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecE/SEC61-gamma family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Essential subunit of the Sec protein translocation channel SecYEG. Clamps together the 2 halves of SecY. May contact the channel plug during translocation. http://togogenome.org/gene/535712:A4Z71_RS05700 ^@ http://purl.uniprot.org/uniprot/A0A1D9E057 ^@ Function|||Subunit ^@ Catalyzes the synthesis of GMP from XMP.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS01655 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY62 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chaperonin (HSP60) family.|||Cell surface|||Cytoplasm|||Forms a cylinder of 14 subunits composed of two heptameric rings stacked back-to-back. Interacts with the co-chaperonin GroES.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Together with its co-chaperonin GroES, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding.|||capsule|||cell wall http://togogenome.org/gene/535712:A4Z71_RS04140 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06785 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Q2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the urocanase family.|||Binds 1 NAD(+) per subunit.|||Catalyzes the conversion of urocanate to 4-imidazolone-5-propionate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02500 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI4 ^@ Function|||Similarity ^@ Belongs to the NAD-dependent DNA ligase family. LigA subfamily.|||DNA ligase that catalyzes the formation of phosphodiester linkages between 5'-phosphoryl and 3'-hydroxyl groups in double-stranded DNA using NAD as a coenzyme and as the energy source for the reaction. It is essential for DNA replication and repair of damaged DNA. http://togogenome.org/gene/535712:A4Z71_RS04080 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NrdR family.|||Binds 1 zinc ion.|||Negatively regulates transcription of bacterial ribonucleotide reductase nrd genes and operons by binding to NrdR-boxes. http://togogenome.org/gene/535712:A4Z71_RS06380 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS04050 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Cell membrane|||Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1-3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01400 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS01570 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY56 ^@ Function|||Similarity ^@ Belongs to the phosphoglycerate mutase family. BPG-dependent PGAM subfamily.|||Catalyzes the interconversion of 2-phosphoglycerate and 3-phosphoglycerate. http://togogenome.org/gene/535712:A4Z71_RS03095 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYW3 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/535712:A4Z71_RS05060 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04505 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZK9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family.|||Can catalyze the hydrolysis of ATP in the presence of single-stranded DNA, the ATP-dependent uptake of single-stranded DNA by duplex DNA, and the ATP-dependent hybridization of homologous single-stranded DNAs. It interacts with LexA causing its activation and leading to its autocatalytic cleavage.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS01575 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY39 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PhoU family.|||Cytoplasm|||Homodimer.|||Plays a role in the regulation of phosphate uptake. http://togogenome.org/gene/535712:A4Z71_RS05715 ^@ http://purl.uniprot.org/uniprot/A0A1D9E069 ^@ Similarity ^@ Belongs to the IMPDH/GMPR family. http://togogenome.org/gene/535712:A4Z71_RS01175 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW9 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subunit ^@ Belongs to the peroxidase family. Peroxidase/catalase subfamily.|||Bifunctional enzyme with both catalase and broad-spectrum peroxidase activity.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per dimer.|||Formation of the three residue Trp-Tyr-Met cross-link is important for the catalase, but not the peroxidase activity of the enzyme.|||Homodimer or homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02855 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYP7 ^@ Similarity ^@ Belongs to the DNA polymerase type-C family. DnaE2 subfamily. http://togogenome.org/gene/535712:A4Z71_RS02820 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Iojap/RsfS family.|||Cytoplasm|||Functions as a ribosomal silencing factor. Interacts with ribosomal protein L14 (rplN), blocking formation of intersubunit bridge B8. Prevents association of the 30S and 50S ribosomal subunits and the formation of functional ribosomes, thus repressing translation.|||Interacts with ribosomal protein L14 (rplN). http://togogenome.org/gene/535712:A4Z71_RS03415 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACO1 family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS01820 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY71 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds 1 Mg(2+) ion per subunit.|||Catalyzes the last two sequential reactions in the de novo biosynthetic pathway for UDP-N-acetylglucosamine (UDP-GlcNAc). The C-terminal domain catalyzes the transfer of acetyl group from acetyl coenzyme A to glucosamine-1-phosphate (GlcN-1-P) to produce N-acetylglucosamine-1-phosphate (GlcNAc-1-P), which is converted into UDP-GlcNAc by the transfer of uridine 5-monophosphate (from uridine 5-triphosphate), a reaction catalyzed by the N-terminal domain.|||Cytoplasm|||Homotrimer.|||In the C-terminal section; belongs to the transferase hexapeptide repeat family.|||In the N-terminal section; belongs to the N-acetylglucosamine-1-phosphate uridyltransferase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04235 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZF3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/535712:A4Z71_RS04690 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS02870 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 1 family.|||Cell inner membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04775 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase delta chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||This protein is part of the stalk that links CF(0) to CF(1). It either transmits conformational changes from CF(0) to CF(1) or is implicated in proton conduction. http://togogenome.org/gene/535712:A4Z71_RS00015 ^@ http://purl.uniprot.org/uniprot/A0A1D9DX89 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bS18 family.|||Binds as a heterodimer with protein S6 to the central domain of the 16S rRNA, where it helps stabilize the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Forms a tight heterodimer with protein S6. http://togogenome.org/gene/535712:A4Z71_RS00230 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXF0 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrE subfamily.|||Catalyzes the transfer of a ribosyl phosphate group from 5-phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05965 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C3 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/535712:A4Z71_RS05720 ^@ http://purl.uniprot.org/uniprot/A0A1D9E059 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IMPDH/GMPR family.|||Catalyzes the conversion of inosine 5'-phosphate (IMP) to xanthosine 5'-phosphate (XMP), the first committed and rate-limiting step in the de novo synthesis of guanine nucleotides, and therefore plays an important role in the regulation of cell growth.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mycophenolic acid (MPA) is a non-competitive inhibitor that prevents formation of the closed enzyme conformation by binding to the same site as the amobile flap. In contrast, mizoribine monophosphate (MZP) is a competitive inhibitor that induces the closed conformation. MPA is a potent inhibitor of mammalian IMPDHs but a poor inhibitor of the bacterial enzymes. MZP is a more potent inhibitor of bacterial IMPDH. http://togogenome.org/gene/535712:A4Z71_RS03330 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYY6 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family. DXPS subfamily.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D-xylulose-5-phosphate (DXP).|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS06035 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03005 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS7 ^@ Similarity ^@ Belongs to the dGTPase family. Type 2 subfamily. http://togogenome.org/gene/535712:A4Z71_RS05165 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZV5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the acetolactate synthase small subunit family.|||Catalyzes the conversion of 2 pyruvate molecules into acetolactate in the first common step of the biosynthetic pathway of the branched-amino acids such as leucine, isoleucine, and valine.|||Dimer of large and small chains. http://togogenome.org/gene/535712:A4Z71_RS05570 ^@ http://purl.uniprot.org/uniprot/A0A1D9E032 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of tryptophan to tRNA(Trp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04765 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase gamma chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c.|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The gamma chain is believed to be important in regulating ATPase activity and the flow of protons through the CF(0) complex. http://togogenome.org/gene/535712:A4Z71_RS01500 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY29 ^@ Function|||Similarity ^@ Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.|||Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. http://togogenome.org/gene/535712:A4Z71_RS04855 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DedA family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02785 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL27 family. http://togogenome.org/gene/535712:A4Z71_RS06055 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS7 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the head domain of the 30S subunit. Is located at the subunit interface close to the decoding center, probably blocks exit of the E-site tRNA.|||Part of the 30S ribosomal subunit. Contacts proteins S9 and S11. http://togogenome.org/gene/535712:A4Z71_RS06685 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0M7 ^@ Function|||Similarity ^@ Belongs to the TrhO family.|||Catalyzes oxygen-dependent 5-hydroxyuridine (ho5U) modification at position 34 in tRNAs. http://togogenome.org/gene/535712:A4Z71_RS01750 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY73 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. SDR39U1 subfamily. http://togogenome.org/gene/535712:A4Z71_RS05970 ^@ http://purl.uniprot.org/uniprot/A0A1D9E095 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS04810 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ2 ^@ Caution|||Function|||Similarity ^@ Belongs to the protein N5-glutamine methyltransferase family. PrmC subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methylates the class 1 translation termination release factors RF1/PrfA and RF2/PrfB on the glutamine residue of the universally conserved GGQ motif. http://togogenome.org/gene/535712:A4Z71_RS02745 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYQ1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. ValS type 2 subfamily.|||Catalyzes the attachment of valine to tRNA(Val). As ValRS can inadvertently accommodate and process structurally similar amino acids such as threonine, to avoid such errors, it has a 'posttransfer' editing activity that hydrolyzes mischarged Thr-tRNA(Val) in a tRNA-dependent manner.|||Cytoplasm|||Monomer.|||ValRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated threonine is translocated from the active site to the editing site. http://togogenome.org/gene/535712:A4Z71_RS03560 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ62 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the CarB family.|||Binds 4 Mg(2+) or Mn(2+) ions per subunit.|||Composed of two chains; the small (or glutamine) chain promotes the hydrolysis of glutamine to ammonia, which is used by the large (or ammonia) chain to synthesize carbamoyl phosphate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02750 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL9 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. IleS type 2 subfamily.|||Catalyzes the attachment of isoleucine to tRNA(Ile). As IleRS can inadvertently accommodate and process structurally similar amino acids such as valine, to avoid such errors it has two additional distinct tRNA(Ile)-dependent editing activities. One activity is designated as 'pretransfer' editing and involves the hydrolysis of activated Val-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Val-tRNA(Ile).|||Cytoplasm|||IleRS has two distinct active sites: one for aminoacylation and one for editing. The misactivated valine is translocated from the active site to the editing site, which sterically excludes the correctly activated isoleucine. The single editing site contains two valyl binding pockets, one specific for each substrate (Val-AMP or Val-tRNA(Ile)).|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS03615 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ69 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP phosphoribosyltransferase family. Long subfamily.|||Catalyzes the condensation of ATP and 5-phosphoribose 1-diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity.|||Cytoplasm|||Feedback inhibited by histidine. http://togogenome.org/gene/535712:A4Z71_RS05845 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IF-1 family.|||Component of the 30S ribosomal translation pre-initiation complex which assembles on the 30S ribosome in the order IF-2 and IF-3, IF-1 and N-formylmethionyl-tRNA(fMet); mRNA recruitment can occur at any time during PIC assembly.|||Cytoplasm|||One of the essential components for the initiation of protein synthesis. Stabilizes the binding of IF-2 and IF-3 on the 30S subunit to which N-formylmethionyl-tRNA(fMet) subsequently binds. Helps modulate mRNA selection, yielding the 30S pre-initiation complex (PIC). Upon addition of the 50S ribosomal subunit IF-1, IF-2 and IF-3 are released leaving the mature 70S translation initiation complex. http://togogenome.org/gene/535712:A4Z71_RS02160 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 42 family. http://togogenome.org/gene/535712:A4Z71_RS05590 ^@ http://purl.uniprot.org/uniprot/A0A1D9E018 ^@ Function|||Similarity ^@ Belongs to the DMRL synthase family.|||Catalyzes the formation of 6,7-dimethyl-8-ribityllumazine by condensation of 5-amino-6-(D-ribitylamino)uracil with 3,4-dihydroxy-2-butanone 4-phosphate. This is the penultimate step in the biosynthesis of riboflavin. http://togogenome.org/gene/535712:A4Z71_RS02340 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Y3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS16 family. http://togogenome.org/gene/535712:A4Z71_RS00010 ^@ http://purl.uniprot.org/uniprot/A0A1D9DX88 ^@ Caution|||Subunit ^@ Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS01275 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXY9 ^@ Function|||Similarity ^@ Belongs to the RecR family.|||May play a role in DNA repair. It seems to be involved in an RecBC-independent recombinational process of DNA repair. It may act with RecF and RecO. http://togogenome.org/gene/535712:A4Z71_RS03365 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonia transporter channel (TC 1.A.11.2) family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS03800 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ67 ^@ Similarity ^@ Belongs to the DNA photolyase family. http://togogenome.org/gene/535712:A4Z71_RS04880 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR3 ^@ Similarity ^@ Belongs to the peptidase S1C family. http://togogenome.org/gene/535712:A4Z71_RS04680 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR5 ^@ Caution|||Function|||Similarity ^@ Belongs to the DXR family.|||Catalyzes the NADPH-dependent rearrangement and reduction of 1-deoxy-D-xylulose-5-phosphate (DXP) to 2-C-methyl-D-erythritol 4-phosphate (MEP).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS01675 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY60 ^@ Similarity ^@ Belongs to the helicase family. RAD25/XPB subfamily. http://togogenome.org/gene/535712:A4Z71_RS06000 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS00625 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM3 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/535712:A4Z71_RS00585 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrcB (TC 9.B.71) family.|||Cell membrane|||Important for reducing fluoride concentration in the cell, thus reducing its toxicity.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01030 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXU8 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/535712:A4Z71_RS06220 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0E6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NucS endonuclease family.|||Cleaves both 3' and 5' ssDNA extremities of branched DNA structures.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05290 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecA family.|||Cell membrane|||Cytoplasm|||Monomer and homodimer. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. Has a central role in coupling the hydrolysis of ATP to the transfer of proteins into and across the cell membrane, serving as an ATP-driven molecular motor driving the stepwise translocation of polypeptide chains across the membrane. http://togogenome.org/gene/535712:A4Z71_RS05670 ^@ http://purl.uniprot.org/uniprot/A0A1D9E047 ^@ Function|||Similarity ^@ Belongs to the GART family.|||Catalyzes the transfer of a formyl group from 10-formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. http://togogenome.org/gene/535712:A4Z71_RS05260 ^@ http://purl.uniprot.org/uniprot/A0A1D9E011 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Acts as a transcriptional regulator. Probably redox-responsive. The apo- but not holo-form probably binds DNA.|||Belongs to the WhiB family.|||Binds 1 [4Fe-4S] cluster per subunit. Following nitrosylation of the [4Fe-4S] cluster binds 1 [4Fe-8(NO)] cluster per subunit.|||Cytoplasm|||The Fe-S cluster can be nitrosylated by nitric oxide (NO).|||Upon Fe-S cluster removal intramolecular disulfide bonds are formed. http://togogenome.org/gene/535712:A4Z71_RS02355 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA methyltransferase TrmD family.|||Cytoplasm|||Homodimer.|||Specifically methylates guanosine-37 in various tRNAs. http://togogenome.org/gene/535712:A4Z71_RS02920 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS2 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bS20 family.|||Binds directly to 16S ribosomal RNA. http://togogenome.org/gene/535712:A4Z71_RS03735 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ65 ^@ Function|||Similarity ^@ Belongs to the iron/manganese superoxide dismutase family.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/535712:A4Z71_RS04290 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI8 ^@ Similarity ^@ Belongs to the prephenate/arogenate dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS06830 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0R7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the type II topoisomerase GyrB family.|||Belongs to the type II topoisomerase family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/535712:A4Z71_RS05940 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL2 family.|||One of the primary rRNA binding proteins. Required for association of the 30S and 50S subunits to form the 70S ribosome, for tRNA binding and peptide bond formation. It has been suggested to have peptidyltransferase activity; this is somewhat controversial. Makes several contacts with the 16S rRNA in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a bridge to the 30S subunit in the 70S ribosome. http://togogenome.org/gene/535712:A4Z71_RS03515 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ15 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sugar phosphate cyclases superfamily. Dehydroquinate synthase family.|||Binds 1 divalent metal cation per subunit. Can use either Co(2+) or Zn(2+).|||Catalyzes the conversion of 3-deoxy-D-arabino-heptulosonate 7-phosphate (DAHP) to dehydroquinate (DHQ).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS03535 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ32 ^@ Function|||Similarity ^@ Also displays a weak uracil phosphoribosyltransferase activity which is not physiologically significant.|||Belongs to the purine/pyrimidine phosphoribosyltransferase family. PyrR subfamily.|||Regulates the transcription of the pyrimidine nucleotide (pyr) operon in response to exogenous pyrimidines. http://togogenome.org/gene/535712:A4Z71_RS02105 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYD5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS07110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZG8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerD subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/535712:A4Z71_RS04425 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL35 family. http://togogenome.org/gene/535712:A4Z71_RS03845 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF1 family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS00095 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD5 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL33 family. http://togogenome.org/gene/535712:A4Z71_RS04385 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. OTCase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05885 ^@ http://purl.uniprot.org/uniprot/A0A1D9E075 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL6 family.|||Part of the 50S ribosomal subunit.|||This protein binds to the 23S rRNA, and is important in its secondary structure. It is located near the subunit interface in the base of the L7/L12 stalk, and near the tRNA binding site of the peptidyltransferase center. http://togogenome.org/gene/535712:A4Z71_RS05225 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZX3 ^@ Function|||Similarity ^@ Belongs to the NadC/ModD family.|||Involved in the catabolism of quinolinic acid (QA). http://togogenome.org/gene/535712:A4Z71_RS04375 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. TyrS type 1 subfamily.|||Catalyzes the attachment of tyrosine to tRNA(Tyr) in a two-step reaction: tyrosine is first activated by ATP to form Tyr-AMP and then transferred to the acceptor end of tRNA(Tyr).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS05660 ^@ http://purl.uniprot.org/uniprot/A0A1D9E036 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/535712:A4Z71_RS02875 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome ubiquinol oxidase subunit 2 family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS03035 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AzlC family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS06575 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0M5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily.|||Catalyzes the attachment of serine to tRNA(Ser). Is also able to aminoacylate tRNA(Sec) with serine, to form the misacylated tRNA L-seryl-tRNA(Sec), which will be further converted into selenocysteinyl-tRNA(Sec).|||Consists of two distinct domains, a catalytic core and a N-terminal extension that is involved in tRNA binding.|||Cytoplasm|||Homodimer. The tRNA molecule binds across the dimer. http://togogenome.org/gene/535712:A4Z71_RS02275 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG0 ^@ Cofactor|||Function ^@ Binds 1 [3Fe-4S] cluster.|||Ferredoxins are iron-sulfur proteins that transfer electrons in a wide variety of metabolic reactions. http://togogenome.org/gene/535712:A4Z71_RS02420 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RRF family.|||Cytoplasm|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/535712:A4Z71_RS04615 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZK5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PstS family.|||Part of the ABC transporter complex PstSACB involved in phosphate import.|||The complex is composed of two ATP-binding proteins (PstB), two transmembrane proteins (PstC and PstA) and a solute-binding protein (PstS). http://togogenome.org/gene/535712:A4Z71_RS06640 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0L5 ^@ Similarity ^@ Belongs to the UPF0065 (bug) family. http://togogenome.org/gene/535712:A4Z71_RS06335 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0G7 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/535712:A4Z71_RS03105 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ 4'-phosphopantetheine is transferred from CoA to a specific serine of apo-ACP by AcpS. This modification is essential for activity because fatty acids are bound in thioester linkage to the sulfhydryl of the prosthetic group.|||Belongs to the acyl carrier protein (ACP) family.|||Carrier of the growing fatty acid chain in fatty acid biosynthesis.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS00865 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR3 ^@ Similarity ^@ Belongs to the UPF0234 family. http://togogenome.org/gene/535712:A4Z71_RS05160 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZW2 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Belongs to the ketol-acid reductoisomerase family.|||Binds 2 magnesium ions per subunit.|||Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS01085 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXV5 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the ribonucleoside diphosphate reductase small chain family.|||Binds 2 iron ions per subunit.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides.|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/535712:A4Z71_RS02380 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH2 ^@ Similarity ^@ Belongs to the UPF0102 family. http://togogenome.org/gene/535712:A4Z71_RS00020 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXC0 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL9 family.|||Binds to the 23S rRNA. http://togogenome.org/gene/535712:A4Z71_RS03730 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ90 ^@ Function|||Similarity ^@ Belongs to the WhiA family.|||Involved in cell division and chromosome segregation. http://togogenome.org/gene/535712:A4Z71_RS03410 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the glutaminase PdxT/SNO family.|||Catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the biosynthesis of pyridoxal 5'-phosphate. The resulting ammonia molecule is channeled to the active site of PdxS.|||In the presence of PdxS, forms a dodecamer of heterodimers. Only shows activity in the heterodimer. http://togogenome.org/gene/535712:A4Z71_RS01165 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS06605 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0K7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01840 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PTH family.|||Cytoplasm|||Monomer.|||The natural substrate for this enzyme may be peptidyl-tRNAs which drop off the ribosome during protein synthesis. http://togogenome.org/gene/535712:A4Z71_RS04900 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS8 ^@ Similarity ^@ Belongs to the peptidase S16 family. http://togogenome.org/gene/535712:A4Z71_RS03045 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the polypeptide deformylase family.|||Binds 1 Fe(2+) ion.|||Removes the formyl group from the N-terminal Met of newly synthesized proteins. Requires at least a dipeptide for an efficient rate of reaction. N-terminal L-methionine is a prerequisite for activity but the enzyme has broad specificity at other positions. http://togogenome.org/gene/535712:A4Z71_RS01530 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY31 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/535712:A4Z71_RS01920 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0U7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS05910 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS17 family.|||One of the primary rRNA binding proteins, it binds specifically to the 5'-end of 16S ribosomal RNA.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS00950 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXT5 ^@ Function|||PTM|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL11 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors.|||One or more lysine residues are methylated.|||Part of the ribosomal stalk of the 50S ribosomal subunit. Interacts with L10 and the large rRNA to form the base of the stalk. L10 forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/535712:A4Z71_RS03220 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYX6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06360 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0H1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal/bacterial/fungal opsin family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02415 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI3 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UMP kinase family.|||Catalyzes the reversible phosphorylation of UMP to UDP.|||Cytoplasm|||Homohexamer.|||Inhibited by UTP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05470 ^@ http://purl.uniprot.org/uniprot/A0A1D9E051 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/535712:A4Z71_RS04380 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04115 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZF9 ^@ Similarity ^@ Belongs to the YggT family. http://togogenome.org/gene/535712:A4Z71_RS06520 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0L8 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Belongs to the HMBS family.|||Binds 1 dipyrromethane group covalently.|||Monomer.|||Tetrapolymerization of the monopyrrole PBG into the hydroxymethylbilane pre-uroporphyrinogen in several discrete steps.|||The porphobilinogen subunits are added to the dipyrromethane group. http://togogenome.org/gene/535712:A4Z71_RS00235 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXF9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01700 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY61 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily. http://togogenome.org/gene/535712:A4Z71_RS06375 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS05020 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU8 ^@ Caution|||Function|||Miscellaneous|||Similarity ^@ Belongs to the thiamine-monophosphate kinase family.|||Catalyzes the ATP-dependent phosphorylation of thiamine-monophosphate (TMP) to form thiamine-pyrophosphate (TPP), the active form of vitamin B1.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction mechanism of ThiL seems to utilize a direct, inline transfer of the gamma-phosphate of ATP to TMP rather than a phosphorylated enzyme intermediate. http://togogenome.org/gene/535712:A4Z71_RS00505 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXL4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FGAMS family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/535712:A4Z71_RS04580 ^@ http://purl.uniprot.org/uniprot/A0A1D9E144 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyribonucleotide nucleotidyltransferase family.|||Cytoplasm|||Involved in mRNA degradation. Catalyzes the phosphorolysis of single-stranded polyribonucleotides processively in the 3'- to 5'-direction. http://togogenome.org/gene/535712:A4Z71_RS05095 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. Glutamate--tRNA ligase type 1 subfamily.|||Catalyzes the attachment of glutamate to tRNA(Glu) in a two-step reaction: glutamate is first activated by ATP to form Glu-AMP and then transferred to the acceptor end of tRNA(Glu).|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS02910 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03170 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYW7 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/535712:A4Z71_RS00880 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXS5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03430 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ09 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvB family.|||Forms a complex with RuvA.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. http://togogenome.org/gene/535712:A4Z71_RS04335 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH4 ^@ Function|||Similarity ^@ Belongs to the RecN family.|||May be involved in recombinational repair of damaged DNA. http://togogenome.org/gene/535712:A4Z71_RS06745 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N4 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/535712:A4Z71_RS06865 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Q5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0161 family.|||Cell membrane|||Could be involved in insertion of integral membrane proteins into the membrane. http://togogenome.org/gene/535712:A4Z71_RS06110 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C7 ^@ Activity Regulation|||Cofactor|||Function|||Similarity ^@ Allosterically activated by GTP.|||Belongs to the UPRTase family.|||Binds 1 Mg(2+) ion per subunit. The magnesium is bound as Mg-PRPP.|||Catalyzes the conversion of uracil and 5-phospho-alpha-D-ribose 1-diphosphate (PRPP) to UMP and diphosphate. http://togogenome.org/gene/535712:A4Z71_RS05230 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZW5 ^@ Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. http://togogenome.org/gene/535712:A4Z71_RS06670 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N1 ^@ Function|||Similarity ^@ Belongs to the ApbE family.|||Flavin transferase that catalyzes the transfer of the FMN moiety of FAD and its covalent binding to the hydroxyl group of a threonine residue in a target flavoprotein. http://togogenome.org/gene/535712:A4Z71_RS05185 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZV7 ^@ Similarity ^@ Belongs to the carotenoid/retinoid oxidoreductase family. http://togogenome.org/gene/535712:A4Z71_RS02240 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0126 family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS00760 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0T5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the attachment of L-aspartate to tRNA(Asp) in a two-step reaction: L-aspartate is first activated by ATP to form Asp-AMP and then transferred to the acceptor end of tRNA(Asp).|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS03100 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV7 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family.|||Involved in the type II fatty acid elongation cycle. Catalyzes the elongation of a wide range of acyl-ACP by the addition of two carbons from malonyl-ACP to an acyl acceptor. Can efficiently catalyze the conversion of palmitoleoyl-ACP (cis-hexadec-9-enoyl-ACP) to cis-vaccenoyl-ACP (cis-octadec-11-enoyl-ACP), an essential step in the thermal regulation of fatty acid composition. http://togogenome.org/gene/535712:A4Z71_RS02665 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYK8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/535712:A4Z71_RS02325 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMC family.|||Contains large globular domains required for ATP hydrolysis at each terminus and a third globular domain forming a flexible hinge near the middle of the molecule. These domains are separated by coiled-coil structures.|||Cytoplasm|||Homodimer.|||Required for chromosome condensation and partitioning. http://togogenome.org/gene/535712:A4Z71_RS05920 ^@ http://purl.uniprot.org/uniprot/A0A1D9E086 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL16 family.|||Binds 23S rRNA and is also seen to make contacts with the A and possibly P site tRNAs.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS01470 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY19 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/535712:A4Z71_RS07025 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the quinolinate synthase family. Type 3 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the condensation of iminoaspartate with dihydroxyacetone phosphate to form quinolinate.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05500 ^@ http://purl.uniprot.org/uniprot/A0A1D9E013 ^@ Similarity|||Subunit ^@ Belongs to the thymidine/pyrimidine-nucleoside phosphorylase family.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS04550 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZK2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the thymidylate synthase ThyX family.|||Binds 4 FAD per tetramer. Each FAD binding site is formed by three monomers.|||Catalyzes the reductive methylation of 2'-deoxyuridine-5'-monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NADPH and FADH(2) as the reductant.|||Homotetramer. http://togogenome.org/gene/535712:A4Z71_RS05730 ^@ http://purl.uniprot.org/uniprot/A0A1D9E084 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS05295 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZY3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPF/YfiA ribosome-associated protein family. Long HPF subfamily.|||Cytoplasm|||Interacts with 100S ribosomes.|||Required for dimerization of active 70S ribosomes into 100S ribosomes in stationary phase; 100S ribosomes are translationally inactive and sometimes present during exponential growth. http://togogenome.org/gene/535712:A4Z71_RS05785 ^@ http://purl.uniprot.org/uniprot/A0A1D9E068 ^@ Function|||Similarity ^@ Belongs to the alanine racemase family.|||Catalyzes the interconversion of L-alanine and D-alanine. May also act on other amino acids. http://togogenome.org/gene/535712:A4Z71_RS01985 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0V6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the class II fructose-bisphosphate aldolase family.|||Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution.|||Catalyzes the aldol condensation of dihydroxyacetone phosphate (DHAP or glycerone-phosphate) with glyceraldehyde 3-phosphate (G3P) to form fructose 1,6-bisphosphate (FBP) in gluconeogenesis and the reverse reaction in glycolysis. http://togogenome.org/gene/535712:A4Z71_RS03240 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYX8 ^@ Cofactor|||Miscellaneous|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||The active site is a redox-active disulfide bond. http://togogenome.org/gene/535712:A4Z71_RS00660 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM7 ^@ Function|||Similarity ^@ Belongs to the DHNA family.|||Catalyzes the conversion of 7,8-dihydroneopterin to 6-hydroxymethyl-7,8-dihydropterin. http://togogenome.org/gene/535712:A4Z71_RS04445 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HisA/HisF family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05840 ^@ http://purl.uniprot.org/uniprot/A0A1D9E081 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS13 family.|||Located at the top of the head of the 30S subunit, it contacts several helices of the 16S rRNA. In the 70S ribosome it contacts the 23S rRNA (bridge B1a) and protein L5 of the 50S subunit (bridge B1b), connecting the 2 subunits; these bridges are implicated in subunit movement. Contacts the tRNAs in the A and P-sites.|||Part of the 30S ribosomal subunit. Forms a loose heterodimer with protein S19. Forms two bridges to the 50S subunit in the 70S ribosome. http://togogenome.org/gene/535712:A4Z71_RS02940 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR6 ^@ Function|||Similarity ^@ Belongs to the HrcA family.|||Negative regulator of class I heat shock genes (grpE-dnaK-dnaJ and groELS operons). Prevents heat-shock induction of these operons. http://togogenome.org/gene/535712:A4Z71_RS05790 ^@ http://purl.uniprot.org/uniprot/A0A1D9E070 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P-Pant transferase superfamily. AcpS family.|||Cytoplasm|||Transfers the 4'-phosphopantetheine moiety from coenzyme A to a Ser of acyl-carrier-protein. http://togogenome.org/gene/535712:A4Z71_RS02995 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Catalyzes the attachment of glycine to tRNA(Gly).|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS00945 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXS2 ^@ Function|||Similarity ^@ Belongs to the NusG family.|||Participates in transcription elongation, termination and antitermination. http://togogenome.org/gene/535712:A4Z71_RS04780 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase B chain family.|||Cell membrane|||Component of the F(0) channel, it forms part of the peripheral stalk, linking F(1) to F(0).|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||F-type ATPases have 2 components, F(1) - the catalytic core - and F(0) - the membrane proton channel. F(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). F(0) has three main subunits: a(1), b(2) and c(10-14). The alpha and beta chains form an alternating ring which encloses part of the gamma chain. F(1) is attached to F(0) by a central stalk formed by the gamma and epsilon chains, while a peripheral stalk is formed by the delta and b chains.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01150 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0T8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS04340 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZJ9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD kinase family.|||Cytoplasm|||Involved in the regulation of the intracellular balance of NAD and NADP, and is a key enzyme in the biosynthesis of NADP. Catalyzes specifically the phosphorylation on 2'-hydroxyl of the adenosine moiety of NAD to yield NADP.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS01020 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXU1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL12 family.|||Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation.|||Homodimer. Part of the ribosomal stalk of the 50S ribosomal subunit. Forms a multimeric L10(L12)X complex, where L10 forms an elongated spine to which 2 to 4 L12 dimers bind in a sequential fashion. Binds GTP-bound translation factors. http://togogenome.org/gene/535712:A4Z71_RS03745 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ61 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS04695 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS00630 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXN5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PPase family.|||Catalyzes the hydrolysis of inorganic pyrophosphate (PPi) forming two phosphate ions.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/535712:A4Z71_RS06735 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CrgA family.|||Cell membrane|||Involved in cell division. http://togogenome.org/gene/535712:A4Z71_RS01705 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY57 ^@ Similarity ^@ Belongs to the peptidase C40 family. http://togogenome.org/gene/535712:A4Z71_RS02060 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC6 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/535712:A4Z71_RS00805 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXQ8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MenA family. Type 1 subfamily.|||Cell membrane|||Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK).|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04820 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ9 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the Rho family.|||Facilitates transcription termination by a mechanism that involves Rho binding to the nascent RNA, activation of Rho's RNA-dependent ATPase activity, and release of the mRNA from the DNA template.|||Homohexamer. The homohexamer assembles into an open ring structure.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02425 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS03595 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ39 ^@ Function|||Similarity ^@ Attaches a formyl group to the free amino group of methionyl-tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus.|||Belongs to the Fmt family. http://togogenome.org/gene/535712:A4Z71_RS04130 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the FtsZ family.|||Cytoplasm|||Essential cell division protein that forms a contractile ring structure (Z ring) at the future cell division site. The regulation of the ring assembly controls the timing and the location of cell division. One of the functions of the FtsZ ring is to recruit other cell division proteins to the septum to produce a new cell wall between the dividing cells. Binds GTP and shows GTPase activity.|||Homodimer. Polymerizes to form a dynamic ring structure in a strictly GTP-dependent manner. Interacts directly with several other division proteins. http://togogenome.org/gene/535712:A4Z71_RS04920 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ3 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/535712:A4Z71_RS02835 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYQ4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DeoC/FbaB aldolase family. DeoC type 1 subfamily.|||Catalyzes a reversible aldol reaction between acetaldehyde and D-glyceraldehyde 3-phosphate to generate 2-deoxy-D-ribose 5-phosphate.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS02655 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL6 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A translation factor that gates the progression of the 70S ribosomal initiation complex (IC, containing tRNA(fMet) in the P-site) into the translation elongation cycle by using a mechanism sensitive to the ATP/ADP ratio. Binds to the 70S ribosome E-site where it modulates the state of the translating ribosome during subunit translocation. ATP hydrolysis probably frees it from the ribosome, which can enter the elongation phase.|||Belongs to the ABC transporter superfamily. ABCF family. Translational throttle EttA subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. Probably contacts ribosomal proteins L1, L5, L33 and S7, the 16S and 23S rRNA and the P-site containing tRNA(fMet).|||The P-site tRNA interaction motif (PtIM domain) probably interacts with the P-site tRNA(fMet) as well as the 23S rRNA.|||The arm domain is inserted in the first ABC transporter domain. Probably contacts ribosomal protein L1. http://togogenome.org/gene/535712:A4Z71_RS01865 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY93 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Catalyzes the reversible conversion of 2-phosphoglycerate into phosphoenolpyruvate. It is essential for the degradation of carbohydrates via glycolysis.|||Cell surface|||Cytoplasm|||Secreted|||The covalent binding to the substrate causes inactivation of the enzyme, and possibly serves as a signal for the export of the protein. http://togogenome.org/gene/535712:A4Z71_RS04150 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01925 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYA3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04185 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmH family.|||Cytoplasm|||Specifically methylates the N4 position of cytidine in position 1402 (C1402) of 16S rRNA. http://togogenome.org/gene/535712:A4Z71_RS06015 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0D3 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/535712:A4Z71_RS05055 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the aconitase/IPM isomerase family. LeuC type 1 subfamily.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/535712:A4Z71_RS04915 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS9 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/535712:A4Z71_RS03405 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ10 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PdxS/SNZ family.|||Catalyzes the formation of pyridoxal 5'-phosphate from ribose 5-phosphate (RBP), glyceraldehyde 3-phosphate (G3P) and ammonia. The ammonia is provided by the PdxT subunit. Can also use ribulose 5-phosphate and dihydroxyacetone phosphate as substrates, resulting from enzyme-catalyzed isomerization of RBP and G3P, respectively.|||In the presence of PdxT, forms a dodecamer of heterodimers. http://togogenome.org/gene/535712:A4Z71_RS06025 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A7 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/535712:A4Z71_RS00425 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXJ7 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/535712:A4Z71_RS05015 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZX4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type 2 tetrahydrodipicolinate N-succinyltransferase family.|||Catalyzes the conversion of the cyclic tetrahydrodipicolinate (THDP) into the acyclic N-succinyl-L-2-amino-6-oxopimelate using succinyl-CoA.|||Cytoplasm|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04245 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZF2 ^@ Function ^@ Catalyzes a 2-step reaction, involving the ATP-dependent carboxylation of the covalently attached biotin in the first step and the transfer of the carboxyl group to pyruvate in the second. http://togogenome.org/gene/535712:A4Z71_RS05950 ^@ http://purl.uniprot.org/uniprot/A0A1D9E098 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL4 family.|||Forms part of the polypeptide exit tunnel.|||One of the primary rRNA binding proteins, this protein initially binds near the 5'-end of the 23S rRNA. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS04870 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ5 ^@ Function|||Similarity ^@ Belongs to the aspartate/glutamate racemases family.|||Provides the (R)-glutamate required for cell wall biosynthesis. http://togogenome.org/gene/535712:A4Z71_RS02695 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN5 ^@ Similarity ^@ Belongs to the LacAB/RpiB family. http://togogenome.org/gene/535712:A4Z71_RS00555 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXL0 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the formation of phosphoribosylamine from phosphoribosylpyrophosphate (PRPP) and glutamine.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/535712:A4Z71_RS06920 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0R5 ^@ Cofactor|||Similarity|||Subunit ^@ Belongs to the class-II pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS03525 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the elongation factor P family.|||Cytoplasm|||Involved in peptide bond synthesis. Stimulates efficient translation and peptide-bond synthesis on native or reconstituted 70S ribosomes in vitro. Probably functions indirectly by altering the affinity of the ribosome for aminoacyl-tRNA, thus increasing their reactivity as acceptors for peptidyl transferase. http://togogenome.org/gene/535712:A4Z71_RS01285 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXZ2 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the aspartate-semialdehyde dehydrogenase family.|||Catalyzes the NADPH-dependent formation of L-aspartate-semialdehyde (L-ASA) by the reductive dephosphorylation of L-aspartyl-4-phosphate.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS06680 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0P5 ^@ Similarity ^@ Belongs to the peptidase M13 family. http://togogenome.org/gene/535712:A4Z71_RS06395 ^@ http://purl.uniprot.org/uniprot/A0A1D9E131 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS04005 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZB5 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/535712:A4Z71_RS03325 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ00 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate. http://togogenome.org/gene/535712:A4Z71_RS03705 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ45 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CoaE family.|||Catalyzes the phosphorylation of the 3'-hydroxyl group of dephosphocoenzyme A to form coenzyme A.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04190 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MraZ family.|||Forms oligomers.|||nucleoid http://togogenome.org/gene/535712:A4Z71_RS05900 ^@ http://purl.uniprot.org/uniprot/A0A1D9E090 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL24 family.|||One of the proteins that surrounds the polypeptide exit tunnel on the outside of the subunit.|||One of two assembly initiator proteins, it binds directly to the 5'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS03785 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transaldolase family. Type 2 subfamily.|||Cytoplasm|||Transaldolase is important for the balance of metabolites in the pentose-phosphate pathway. http://togogenome.org/gene/535712:A4Z71_RS02220 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SmpB family.|||Cytoplasm|||Required for rescue of stalled ribosomes mediated by trans-translation. Binds to transfer-messenger RNA (tmRNA), required for stable association of tmRNA with ribosomes. tmRNA and SmpB together mimic tRNA shape, replacing the anticodon stem-loop with SmpB. tmRNA is encoded by the ssrA gene; the 2 termini fold to resemble tRNA(Ala) and it encodes a 'tag peptide', a short internal open reading frame. During trans-translation Ala-aminoacylated tmRNA acts like a tRNA, entering the A-site of stalled ribosomes, displacing the stalled mRNA. The ribosome then switches to translate the ORF on the tmRNA; the nascent peptide is terminated with the 'tag peptide' encoded by the tmRNA and targeted for degradation. The ribosome is freed to recommence translation, which seems to be the essential function of trans-translation. http://togogenome.org/gene/535712:A4Z71_RS03760 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ70 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase-binding protein RbpA family.|||Bind 1 Zn(2+) per subunit.|||Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.|||Forms a complex with the RNAP catalytic core and with free principal sigma factors. http://togogenome.org/gene/535712:A4Z71_RS03575 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ26 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase subunit omega family.|||Promotes RNA polymerase assembly. Latches the N- and C-terminal regions of the beta' subunit thereby facilitating its interaction with the beta and alpha subunits.|||The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription. http://togogenome.org/gene/535712:A4Z71_RS00845 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR2 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/535712:A4Z71_RS05665 ^@ http://purl.uniprot.org/uniprot/A0A1D9E058 ^@ Domain|||Similarity ^@ Belongs to the PurH family.|||The IMP cyclohydrolase activity resides in the N-terminal region. http://togogenome.org/gene/535712:A4Z71_RS03140 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine-cytosine permease (2.A.39) family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS05830 ^@ http://purl.uniprot.org/uniprot/A0A1D9E088 ^@ Domain|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase alpha chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Homodimer. The RNAP catalytic core consists of 2 alpha, 1 beta, 1 beta' and 1 omega subunit. When a sigma factor is associated with the core the holoenzyme is formed, which can initiate transcription.|||The N-terminal domain is essential for RNAP assembly and basal transcription, whereas the C-terminal domain is involved in interaction with transcriptional regulators and with upstream promoter elements. http://togogenome.org/gene/535712:A4Z71_RS02595 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYM0 ^@ Function|||Similarity ^@ Belongs to the AlaDH/PNT family.|||Catalyzes the reversible reductive amination of pyruvate to L-alanine. http://togogenome.org/gene/535712:A4Z71_RS02660 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYP0 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/535712:A4Z71_RS06345 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0L3 ^@ Caution|||Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. RlmN family.|||Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Reaction proceeds by a ping-pong mechanism involving intermediate methylation of a conserved cysteine residue.|||Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. http://togogenome.org/gene/535712:A4Z71_RS05805 ^@ http://purl.uniprot.org/uniprot/A0A1D9E094 ^@ Cofactor|||Function|||PTM|||Similarity ^@ Activated by phosphorylation.|||Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of glucosamine-6-phosphate to glucosamine-1-phosphate. http://togogenome.org/gene/535712:A4Z71_RS00225 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXF4 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/535712:A4Z71_RS06535 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0L6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. HemL subfamily.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS00535 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXL5 ^@ Similarity ^@ Belongs to the GARS family. http://togogenome.org/gene/535712:A4Z71_RS06525 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0P3 ^@ Function|||Similarity ^@ Belongs to the uroporphyrinogen-III synthase family.|||Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III. http://togogenome.org/gene/535712:A4Z71_RS03875 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ93 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the bacterial/plant glucose-1-phosphate adenylyltransferase family.|||Homotetramer.|||Involved in the biosynthesis of ADP-glucose, a building block required for the elongation reactions to produce glycogen. Catalyzes the reaction between ATP and alpha-D-glucose 1-phosphate (G1P) to produce pyrophosphate and ADP-Glc.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS03965 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatA/E family.|||Cell membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. TatA could form the protein-conducting channel of the Tat system.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/535712:A4Z71_RS03425 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ03 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RuvA family.|||Forms a complex with RuvB.|||The RuvA-RuvB complex in the presence of ATP renatures cruciform structure in supercoiled DNA with palindromic sequence, indicating that it may promote strand exchange reactions in homologous recombination. RuvAB is a helicase that mediates the Holliday junction migration by localized denaturation and reannealing. RuvA stimulates, in the presence of DNA, the weak ATPase activity of RuvB. http://togogenome.org/gene/535712:A4Z71_RS03715 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ44 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. UvrA family.|||Cytoplasm|||Forms a heterotetramer with UvrB during the search for lesions.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrA is an ATPase and a DNA-binding protein. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. When the presence of a lesion has been verified by UvrB, the UvrA molecules dissociate. http://togogenome.org/gene/535712:A4Z71_RS04525 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01780 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methyltransferase superfamily. RsmI family.|||Belongs to the precorrin methyltransferase family.|||Catalyzes the 2'-O-methylation of the ribose of cytidine 1402 (C1402) in 16S rRNA.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS00790 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXP8 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 1 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/535712:A4Z71_RS04755 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase epsilon chain family.|||Cell membrane|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel. CF(1) has five subunits: alpha(3), beta(3), gamma(1), delta(1), epsilon(1). CF(0) has three main subunits: a, b and c. http://togogenome.org/gene/535712:A4Z71_RS03890 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ91 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL31 family. Type B subfamily.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS03775 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ72 ^@ Caution|||Function|||Similarity ^@ Belongs to the glucose-6-phosphate dehydrogenase family.|||Catalyzes the oxidation of glucose 6-phosphate to 6-phosphogluconolactone.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05030 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the D-alanine--D-alanine ligase family.|||Binds 2 magnesium or manganese ions per subunit.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03010 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the DnaG primase family.|||Binds 1 zinc ion per monomer.|||Contains an N-terminal zinc-binding domain, a central core domain that contains the primase activity, and a C-terminal DnaB-binding domain.|||Monomer. Interacts with DnaB.|||RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. http://togogenome.org/gene/535712:A4Z71_RS00105 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD2 ^@ Similarity ^@ Belongs to the bacterial histone-like protein family. http://togogenome.org/gene/535712:A4Z71_RS05115 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZV6 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/535712:A4Z71_RS04390 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the acetylglutamate kinase family. ArgB subfamily.|||Catalyzes the ATP-dependent phosphorylation of N-acetyl-L-glutamate.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04020 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZA7 ^@ Caution|||PTM|||Subcellular Location Annotation|||Subunit ^@ Binds 2 heme c groups covalently per subunit.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||The cytochrome bc1 complex is composed of a cytochrome b (QcrB), the Rieske iron-sulfur protein (QcrA) and a diheme cytochrome c (QcrC) subunit. http://togogenome.org/gene/535712:A4Z71_RS02700 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYM8 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/535712:A4Z71_RS00320 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXH8 ^@ Similarity ^@ Belongs to the hyi family. http://togogenome.org/gene/535712:A4Z71_RS01940 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0W1 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.|||Cytoplasm|||Homotetramer.|||Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate.|||There are 2 substrate-binding sites: the catalytic A site, and the non-catalytic B site that may play a role in the transfer of substrate or product between the active site and the solvent. Alternatively, the B site may bind allosteric effectors. http://togogenome.org/gene/535712:A4Z71_RS02620 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN3 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/535712:A4Z71_RS01015 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXU3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL10 family.|||Forms part of the ribosomal stalk, playing a central role in the interaction of the ribosome with GTP-bound translation factors.|||Part of the ribosomal stalk of the 50S ribosomal subunit. The N-terminus interacts with L11 and the large rRNA to form the base of the stalk. The C-terminus forms an elongated spine to which L12 dimers bind in a sequential fashion forming a multimeric L10(L12)X complex. http://togogenome.org/gene/535712:A4Z71_RS05645 ^@ http://purl.uniprot.org/uniprot/A0A1D9E031 ^@ Function|||Similarity ^@ Belongs to the PurU family.|||Catalyzes the hydrolysis of 10-formyltetrahydrofolate (formyl-FH4) to formate and tetrahydrofolate (FH4). http://togogenome.org/gene/535712:A4Z71_RS00715 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrroline-5-carboxylate reductase family.|||Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS00350 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS03505 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ52 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the chorismate synthase family.|||Catalyzes the anti-1,4-elimination of the C-3 phosphate and the C-6 proR hydrogen from 5-enolpyruvylshikimate-3-phosphate (EPSP) to yield chorismate, which is the branch point compound that serves as the starting substrate for the three terminal pathways of aromatic amino acid biosynthesis. This reaction introduces a second double bond into the aromatic ring system.|||Homotetramer.|||Reduced FMN (FMNH(2)). http://togogenome.org/gene/535712:A4Z71_RS03810 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ79 ^@ Similarity ^@ Belongs to the UPF0051 (ycf24) family. http://togogenome.org/gene/535712:A4Z71_RS04395 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH2 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ArgJ family.|||Catalyzes two activities which are involved in the cyclic version of arginine biosynthesis: the synthesis of N-acetylglutamate from glutamate and acetyl-CoA as the acetyl donor, and of ornithine by transacetylation between N(2)-acetylornithine and glutamate.|||Cytoplasm|||Heterotetramer of two alpha and two beta chains.|||Some bacteria possess a monofunctional ArgJ, i.e., capable of catalyzing only the fifth step of the arginine biosynthetic pathway. http://togogenome.org/gene/535712:A4Z71_RS06405 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0M3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 32 family. http://togogenome.org/gene/535712:A4Z71_RS02980 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYT6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 2 subfamily.|||Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3-hydroxy-4-methylpentanoate (2-isopropylmalate).|||Homotetramer. http://togogenome.org/gene/535712:A4Z71_RS02075 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYD1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. RsgA subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. Associates with 30S ribosomal subunit, binds 16S rRNA.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Helps release RbfA from mature subunits. May play a role in the assembly of ribosomal proteins into the subunit. Circularly permuted GTPase that catalyzes slow GTP hydrolysis, GTPase activity is stimulated by the 30S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS01460 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bacterial solute-binding protein SsuA/TauA family.|||Periplasm http://togogenome.org/gene/535712:A4Z71_RS05895 ^@ http://purl.uniprot.org/uniprot/A0A1D9E091 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL5 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA and the P site tRNA. Forms a bridge to the 30S subunit in the 70S ribosome.|||This is 1 of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. In the 70S ribosome it contacts protein S13 of the 30S subunit (bridge B1b), connecting the 2 subunits; this bridge is implicated in subunit movement. Contacts the P site tRNA; the 5S rRNA and some of its associated proteins might help stabilize positioning of ribosome-bound tRNAs. http://togogenome.org/gene/535712:A4Z71_RS00140 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXE3 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the dCTP deaminase family.|||Bifunctional enzyme that catalyzes both the deamination of dCTP to dUTP and the hydrolysis of dUTP to dUMP without releasing the toxic dUTP intermediate.|||Homotrimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05045 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPSP synthase family. MurA subfamily.|||Cell wall formation. Adds enolpyruvyl to UDP-N-acetylglucosamine.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS00890 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04585 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZM0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS15 family.|||Forms an intersubunit bridge (bridge B4) with the 23S rRNA of the 50S subunit in the ribosome.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it helps nucleate assembly of the platform of the 30S subunit by binding and bridging several RNA helices of the 16S rRNA.|||Part of the 30S ribosomal subunit. Forms a bridge to the 50S subunit in the 70S ribosome, contacting the 23S rRNA. http://togogenome.org/gene/535712:A4Z71_RS03225 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYX7 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LipB family.|||Catalyzes the transfer of endogenously produced octanoic acid from octanoyl-acyl-carrier-protein onto the lipoyl domains of lipoate-dependent enzymes. Lipoyl-ACP can also act as a substrate although octanoyl-ACP is likely to be the physiological substrate.|||Cytoplasm|||In the reaction, the free carboxyl group of octanoic acid is attached via an amide linkage to the epsilon-amino group of a specific lysine residue of lipoyl domains of lipoate-dependent enzymes. http://togogenome.org/gene/535712:A4Z71_RS03600 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ28 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/535712:A4Z71_RS01880 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0V1 ^@ Similarity ^@ Belongs to the NADH dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS02370 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG6 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RNase HII family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids.|||Manganese or magnesium. Binds 1 divalent metal ion per monomer in the absence of substrate. May bind a second metal ion after substrate binding. http://togogenome.org/gene/535712:A4Z71_RS06560 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0L2 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/535712:A4Z71_RS03485 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ20 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged Ser-tRNA(Ala) and Gly-tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04200 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZD4 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/535712:A4Z71_RS03750 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the triosephosphate isomerase family.|||Cytoplasm|||Homodimer.|||Involved in the gluconeogenesis. Catalyzes stereospecifically the conversion of dihydroxyacetone phosphate (DHAP) to D-glyceraldehyde-3-phosphate (G3P). http://togogenome.org/gene/535712:A4Z71_RS03565 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ36 ^@ Similarity ^@ Belongs to the OMP decarboxylase family. Type 2 subfamily. http://togogenome.org/gene/535712:A4Z71_RS01970 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB5 ^@ Similarity ^@ Belongs to the bacterial solute-binding protein 3 family. http://togogenome.org/gene/535712:A4Z71_RS01365 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS06330 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0G8 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allosterically activated by fructose 1,6-bisphosphate (FBP).|||Belongs to the LDH/MDH superfamily. LDH family.|||Catalyzes the conversion of lactate to pyruvate.|||Cytoplasm|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05640 ^@ http://purl.uniprot.org/uniprot/A0A1D9E065 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SHMT family.|||Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS01090 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0V5 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/535712:A4Z71_RS01895 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYA0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48B family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02120 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NnrD/CARKD family.|||Catalyzes the dehydration of the S-form of NAD(P)HX at the expense of ADP, which is converted to AMP. Together with NAD(P)HX epimerase, which catalyzes the epimerization of the S- and R-forms, the enzyme allows the repair of both epimers of NAD(P)HX, a damaged form of NAD(P)H that is a result of enzymatic or heat-dependent hydration.|||Homotetramer. http://togogenome.org/gene/535712:A4Z71_RS02285 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG3 ^@ Similarity ^@ Belongs to the citrate synthase family. http://togogenome.org/gene/535712:A4Z71_RS04120 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SepF family.|||Cell division protein that is part of the divisome complex and is recruited early to the Z-ring. Probably stimulates Z-ring formation, perhaps through the cross-linking of FtsZ protofilaments. Its function overlaps with FtsA.|||Cytoplasm|||Homodimer. Interacts with FtsZ. http://togogenome.org/gene/535712:A4Z71_RS01830 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY82 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03000 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYT9 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of 5,6-dihydrouridine (D), a modified base found in the D-loop of most tRNAs, via the reduction of the C5-C6 double bond in target uridines. http://togogenome.org/gene/535712:A4Z71_RS06620 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0M2 ^@ Similarity ^@ Belongs to the N(4)/N(6)-methyltransferase family. http://togogenome.org/gene/535712:A4Z71_RS02585 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04665 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. ProS type 1 subfamily.|||Catalyzes the attachment of proline to tRNA(Pro) in a two-step reaction: proline is first activated by ATP to form Pro-AMP and then transferred to the acceptor end of tRNA(Pro). As ProRS can inadvertently accommodate and process non-cognate amino acids such as alanine and cysteine, to avoid such errors it has two additional distinct editing activities against alanine. One activity is designated as 'pretransfer' editing and involves the tRNA(Pro)-independent hydrolysis of activated Ala-AMP. The other activity is designated 'posttransfer' editing and involves deacylation of mischarged Ala-tRNA(Pro). The misacylated Cys-tRNA(Pro) is not edited by ProRS.|||Consists of three domains: the N-terminal catalytic domain, the editing domain and the C-terminal anticodon-binding domain.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS04160 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family. MraY subfamily.|||Catalyzes the initial step of the lipid cycle reactions in the biosynthesis of the cell wall peptidoglycan: transfers peptidoglycan precursor phospho-MurNAc-pentapeptide from UDP-MurNAc-pentapeptide onto the lipid carrier undecaprenyl phosphate, yielding undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide, known as lipid I.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01205 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXX5 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/535712:A4Z71_RS00090 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL28 family. http://togogenome.org/gene/535712:A4Z71_RS01900 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY85 ^@ Similarity ^@ Belongs to the serine/threonine dehydratase family. http://togogenome.org/gene/535712:A4Z71_RS03835 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BioY family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS01805 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY86 ^@ Function|||Similarity ^@ Belongs to the GHMP kinase family. IspE subfamily.|||Catalyzes the phosphorylation of the position 2 hydroxy group of 4-diphosphocytidyl-2C-methyl-D-erythritol. http://togogenome.org/gene/535712:A4Z71_RS03620 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HisA/HisF family.|||Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. http://togogenome.org/gene/535712:A4Z71_RS01425 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY22 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/535712:A4Z71_RS00025 ^@ http://purl.uniprot.org/uniprot/A0A1D9DX87 ^@ Function|||Similarity ^@ Belongs to the helicase family. DnaB subfamily.|||Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. http://togogenome.org/gene/535712:A4Z71_RS03710 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ58 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrB family.|||Cytoplasm|||Forms a heterotetramer with UvrA during the search for lesions. Interacts with UvrC in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. A damage recognition complex composed of 2 UvrA and 2 UvrB subunits scans DNA for abnormalities. Upon binding of the UvrA(2)B(2) complex to a putative damaged site, the DNA wraps around one UvrB monomer. DNA wrap is dependent on ATP binding by UvrB and probably causes local melting of the DNA helix, facilitating insertion of UvrB beta-hairpin between the DNA strands. Then UvrB probes one DNA strand for the presence of a lesion. If a lesion is found the UvrA subunits dissociate and the UvrB-DNA preincision complex is formed. This complex is subsequently bound by UvrC and the second UvrB is released. If no lesion is found, the DNA wraps around the other UvrB subunit that will check the other stand for damage.|||The beta-hairpin motif is involved in DNA binding. http://togogenome.org/gene/535712:A4Z71_RS02310 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYF8 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL32 family. http://togogenome.org/gene/535712:A4Z71_RS04735 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS5 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGMT family.|||Cytoplasm|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated.|||This enzyme catalyzes only one turnover and therefore is not strictly catalytic. According to one definition, an enzyme is a biocatalyst that acts repeatedly and over many reaction cycles. http://togogenome.org/gene/535712:A4Z71_RS02680 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MscS (TC 1.A.23) family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04010 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZA3 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the anthranilate phosphoribosyltransferase family.|||Binds 2 magnesium ions per monomer.|||Catalyzes the transfer of the phosphoribosyl group of 5-phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'-phosphoribosyl)-anthranilate (PRA).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS03090 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV0 ^@ Function|||Similarity ^@ Belongs to the mandelate racemase/muconate lactonizing enzyme family. MenC type 2 subfamily.|||Converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 2-succinylbenzoate (OSB). http://togogenome.org/gene/535712:A4Z71_RS01890 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LemA family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04170 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE9 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurE subfamily.|||Carboxylation is probably crucial for Mg(2+) binding and, consequently, for the gamma-phosphate positioning of ATP.|||Catalyzes the addition of an amino acid to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanyl-D-glutamate (UMAG) in the biosynthesis of bacterial cell-wall peptidoglycan.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04630 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/535712:A4Z71_RS00825 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS02540 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS04485 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZJ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the diaminopimelate epimerase family.|||Catalyzes the stereoinversion of LL-2,6-diaminoheptanedioate (L,L-DAP) to meso-diaminoheptanedioate (meso-DAP), a precursor of L-lysine and an essential component of the bacterial peptidoglycan.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02300 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bacterial CoaD family.|||Cytoplasm|||Homohexamer.|||Reversibly transfers an adenylyl group from ATP to 4'-phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. http://togogenome.org/gene/535712:A4Z71_RS03990 ^@ http://purl.uniprot.org/uniprot/A0A1D9E107 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the RNA polymerase-binding protein RbpA family.|||Bind 1 Zn(2+) per subunit.|||Binds to RNA polymerase (RNAP), stimulating transcription from principal, but not alternative sigma factor promoters.|||Forms a complex with the RNAP catalytic core and with free principal sigma factors. http://togogenome.org/gene/535712:A4Z71_RS03420 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the RuvC family.|||Binds 1 Mg(2+) ion per subunit.|||Nuclease that resolves Holliday junction intermediates in genetic recombination. Cleaves the cruciform structure in supercoiled DNA by nicking to strands with the same polarity at sites symmetrically opposed at the junction in the homologous arms and leaves a 5'-terminal phosphate and a 3'-terminal hydroxyl group. http://togogenome.org/gene/535712:A4Z71_RS03390 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Y0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS05685 ^@ http://purl.uniprot.org/uniprot/A0A1D9E089 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase beta subunit family.|||Binds 1 Mg(2+) ion per subunit.|||Heterotetramer of two alpha and two beta subunits.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. http://togogenome.org/gene/535712:A4Z71_RS01955 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the XseB family.|||Bidirectionally degrades single-stranded DNA into large acid-insoluble oligonucleotides, which are then degraded further into small acid-soluble oligonucleotides.|||Cytoplasm|||Heterooligomer composed of large and small subunits. http://togogenome.org/gene/535712:A4Z71_RS05410 ^@ http://purl.uniprot.org/uniprot/A0A1D9E025 ^@ Function|||Similarity ^@ Belongs to the AIR carboxylase family. Class I subfamily.|||Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR). http://togogenome.org/gene/535712:A4Z71_RS01905 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYA1 ^@ Function|||Similarity ^@ Belongs to the GreA/GreB family.|||Necessary for efficient RNA polymerase transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by cleavage factors such as GreA or GreB allows the resumption of elongation from the new 3'terminus. GreA releases sequences of 2 to 3 nucleotides. http://togogenome.org/gene/535712:A4Z71_RS06050 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04985 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mrp/NBP35 ATP-binding proteins family.|||Binds and transfers iron-sulfur (Fe-S) clusters to target apoproteins. Can hydrolyze ATP.|||Homodimer.|||In the C-terminal section; belongs to the Mrp/NBP35 ATP-binding proteins family.|||In the N-terminal section; belongs to the MIP18 family. http://togogenome.org/gene/535712:A4Z71_RS00155 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXE5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01445 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02205 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0X2 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF2.|||Peptide chain release factor 2 directs the termination of translation in response to the peptide chain termination codons UGA and UAA. http://togogenome.org/gene/535712:A4Z71_RS02810 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN1 ^@ Function|||Similarity ^@ Belongs to the NadD family.|||Catalyzes the reversible adenylation of nicotinate mononucleotide (NaMN) to nicotinic acid adenine dinucleotide (NaAD). http://togogenome.org/gene/535712:A4Z71_RS06710 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03805 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ66 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03285 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYY0 ^@ Similarity ^@ Belongs to the type II topoisomerase GyrA/ParC subunit family. http://togogenome.org/gene/535712:A4Z71_RS05575 ^@ http://purl.uniprot.org/uniprot/A0A1D9E056 ^@ Cofactor|||Function|||Similarity ^@ Binds 1 zinc ion.|||Converts 2,5-diamino-6-(ribosylamino)-4(3h)-pyrimidinone 5'-phosphate into 5-amino-6-(ribosylamino)-2,4(1h,3h)-pyrimidinedione 5'-phosphate.|||In the C-terminal section; belongs to the HTP reductase family.|||In the N-terminal section; belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/535712:A4Z71_RS02110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01155 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01550 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY38 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity ^@ Belongs to the nitrobindin family.|||Binds 1 heme b group per subunit, that coordinates a highly solvent-exposed Fe(III) atom.|||Forms a 10-stranded antiparallel beta-barrel structure able to accommodate a hydrophobic ligand in its interior. In fact, this fold hosts the heme group, which is located in a wide surface cleft.|||Heme-binding protein able to scavenge peroxynitrite and to protect free L-tyrosine against peroxynitrite-mediated nitration, by acting as a peroxynitrite isomerase that converts peroxynitrite to nitrate. Therefore, this protein likely plays a role in peroxynitrite sensing and in the detoxification of reactive nitrogen and oxygen species (RNS and ROS, respectively). Is able to bind nitric oxide (NO) in vitro, but may act as a sensor of peroxynitrite levels in vivo.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02315 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribonuclease III family.|||Cytoplasm|||Digests double-stranded RNA. Involved in the processing of primary rRNA transcript to yield the immediate precursors to the large and small rRNAs (23S and 16S). Processes some mRNAs, and tRNAs when they are encoded in the rRNA operon. Processes pre-crRNA and tracrRNA of type II CRISPR loci if present in the organism.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS05945 ^@ http://purl.uniprot.org/uniprot/A0A1D9E097 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL23 family.|||One of the early assembly proteins it binds 23S rRNA. One of the proteins that surrounds the polypeptide exit tunnel on the outside of the ribosome. Forms the main docking site for trigger factor binding to the ribosome.|||Part of the 50S ribosomal subunit. Contacts protein L29, and trigger factor when it is bound to the ribosome. http://togogenome.org/gene/535712:A4Z71_RS07095 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0H5 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/535712:A4Z71_RS02725 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYM4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S14 family.|||Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins.|||Cytoplasm|||Fourteen ClpP subunits assemble into 2 heptameric rings which stack back to back to give a disk-like structure with a central cavity, resembling the structure of eukaryotic proteasomes. http://togogenome.org/gene/535712:A4Z71_RS03350 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ4 ^@ Similarity ^@ Belongs to the SufE family. http://togogenome.org/gene/535712:A4Z71_RS05460 ^@ http://purl.uniprot.org/uniprot/A0A1D9E009 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Maf family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleoside triphosphate pyrophosphatase. May have a dual role in cell division arrest and in preventing the incorporation of modified nucleotides into cellular nucleic acids. http://togogenome.org/gene/535712:A4Z71_RS01965 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY98 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the IspH family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. http://togogenome.org/gene/535712:A4Z71_RS05705 ^@ http://purl.uniprot.org/uniprot/A0A1D9E063 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS03795 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ68 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family. Protoheme IX farnesyltransferase subfamily.|||Carbon 2 of the heme B porphyrin ring is defined according to the Fischer nomenclature.|||Cell membrane|||Converts heme B (protoheme IX) to heme O by substitution of the vinyl group on carbon 2 of heme B porphyrin ring with a hydroxyethyl farnesyl side group.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02080 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EPSP synthase family.|||Catalyzes the transfer of the enolpyruvyl moiety of phosphoenolpyruvate (PEP) to the 5-hydroxyl of shikimate-3-phosphate (S3P) to produce enolpyruvyl shikimate-3-phosphate and inorganic phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS04455 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the imidazoleglycerol-phosphate dehydratase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS05850 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B9 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Monomer.|||Removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). Requires deformylation of the N(alpha)-formylated initiator methionine before it can be hydrolyzed. http://togogenome.org/gene/535712:A4Z71_RS06045 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0C6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||Cytoplasm|||Monomer.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/535712:A4Z71_RS05325 ^@ http://purl.uniprot.org/uniprot/A0A1D9E160 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/535712:A4Z71_RS03790 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ73 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the transketolase family.|||Binds 1 Mg(2+) ion per subunit. Can also utilize other divalent metal cations, such as Ca(2+), Mn(2+) and Co(2+).|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the transfer of a two-carbon ketol group from a ketose donor to an aldose acceptor, via a covalent intermediate with the cofactor thiamine pyrophosphate.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS03125 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0X5 ^@ Function ^@ Component of the pyruvate dehydrogenase (PDH) complex, that catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2). http://togogenome.org/gene/535712:A4Z71_RS04815 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP5 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Cytoplasm|||Methylated by PrmC. Methylation increases the termination efficiency of RF1.|||Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA. http://togogenome.org/gene/535712:A4Z71_RS01495 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY16 ^@ Similarity ^@ Belongs to the PrpD family. http://togogenome.org/gene/535712:A4Z71_RS02215 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-4 integral membrane protein family. FtsX subfamily.|||Cell membrane|||Membrane|||Part of the ABC transporter FtsEX involved in cellular division. http://togogenome.org/gene/535712:A4Z71_RS05925 ^@ http://purl.uniprot.org/uniprot/A0A1D9E099 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS3 family.|||Binds the lower part of the 30S subunit head. Binds mRNA in the 70S ribosome, positioning it for translation.|||Part of the 30S ribosomal subunit. Forms a tight complex with proteins S10 and S14. http://togogenome.org/gene/535712:A4Z71_RS04410 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZJ1 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Phe-tRNA synthetase alpha subunit type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/535712:A4Z71_RS03765 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ54 ^@ Function|||Similarity ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family. 6-phosphogluconolactonase subfamily.|||Hydrolysis of 6-phosphogluconolactone to 6-phosphogluconate. http://togogenome.org/gene/535712:A4Z71_RS01660 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY54 ^@ Similarity ^@ Belongs to the WXG100 family. http://togogenome.org/gene/535712:A4Z71_RS05745 ^@ http://purl.uniprot.org/uniprot/A0A1D9E082 ^@ Similarity ^@ Belongs to the leucine-binding protein family. http://togogenome.org/gene/535712:A4Z71_RS05800 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic pantothenate kinase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS00065 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD8 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS04450 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Heterodimer of HisH and HisF.|||IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. http://togogenome.org/gene/535712:A4Z71_RS02515 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYK4 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in organisms which lack glutaminyl-tRNA synthetase. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/535712:A4Z71_RS05935 ^@ http://purl.uniprot.org/uniprot/A0A1D9E085 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS19 family.|||Protein S19 forms a complex with S13 that binds strongly to the 16S ribosomal RNA. http://togogenome.org/gene/535712:A4Z71_RS04110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DivIVA family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04345 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI2 ^@ Similarity ^@ Belongs to the TlyA family. http://togogenome.org/gene/535712:A4Z71_RS03470 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS4 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA where it nucleates assembly of the body of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts protein S5. The interaction surface between S4 and S5 is involved in control of translational fidelity.|||With S5 and S12 plays an important role in translational accuracy. http://togogenome.org/gene/535712:A4Z71_RS00250 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NhaA Na(+)/H(+) (TC 2.A.33) antiporter family.|||Cell inner membrane|||Cell membrane|||Membrane|||Na(+)/H(+) antiporter that extrudes sodium in exchange for external protons. http://togogenome.org/gene/535712:A4Z71_RS00370 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXI5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS02125 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 87 family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS05960 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0D9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS10 family.|||Involved in the binding of tRNA to the ribosomes.|||Part of the 30S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS03120 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV6 ^@ Similarity ^@ Belongs to the CdaR family. http://togogenome.org/gene/535712:A4Z71_RS05035 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS02410 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Associates with the EF-Tu.GDP complex and induces the exchange of GDP to GTP. It remains bound to the aminoacyl-tRNA.EF-Tu.GTP complex up to the GTP hydrolysis stage on the ribosome.|||Belongs to the EF-Ts family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04760 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The catalytic sites are hosted primarily by the beta subunits. http://togogenome.org/gene/535712:A4Z71_RS02390 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG7 ^@ Similarity ^@ Belongs to the DprA/Smf family. http://togogenome.org/gene/535712:A4Z71_RS04225 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE2 ^@ Similarity ^@ Belongs to the ROK (NagC/XylR) family. http://togogenome.org/gene/535712:A4Z71_RS01315 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXZ7 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/535712:A4Z71_RS01280 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY07 ^@ Function|||Similarity ^@ Belongs to the aspartokinase family.|||Catalyzes the phosphorylation of the beta-carboxyl group of aspartic acid with ATP to yield 4-phospho-L-aspartate, which is involved in the branched biosynthetic pathway leading to the biosynthesis of amino acids lysine, threonine, isoleucine and methionine. http://togogenome.org/gene/535712:A4Z71_RS00840 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR0 ^@ Function|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Methyltransferase required for the conversion of demethylmenaquinol (DMKH2) to menaquinol (MKH2). http://togogenome.org/gene/535712:A4Z71_RS03435 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YajC family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04650 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZM1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. IF-2 subfamily.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||One of the essential components for the initiation of protein synthesis. Protects formylmethionyl-tRNA from spontaneous hydrolysis and promotes its binding to the 30S ribosomal subunits. Also involved in the hydrolysis of GTP during the formation of the 70S ribosomal complex. http://togogenome.org/gene/535712:A4Z71_RS03195 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/535712:A4Z71_RS00820 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXQ3 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the TPP enzyme family. MenD subfamily.|||Binds 1 thiamine pyrophosphate per subunit.|||Catalyzes the thiamine diphosphate-dependent decarboxylation of 2-oxoglutarate and the subsequent addition of the resulting succinic semialdehyde-thiamine pyrophosphate anion to isochorismate to yield 2-succinyl-5-enolpyruvyl-6-hydroxy-3-cyclohexene-1-carboxylate (SEPHCHC).|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS03145 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU3 ^@ Similarity ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family. http://togogenome.org/gene/535712:A4Z71_RS06460 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Brp/Blh beta-carotene diooxygenase family.|||Catalyzes the cleavage of beta-carotene at its central double bond (15,15') to yield two molecules of all-trans-retinal.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS04165 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZG9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family. MurF subfamily.|||Cytoplasm|||Involved in cell wall formation. Catalyzes the final step in the synthesis of UDP-N-acetylmuramoyl-pentapeptide, the precursor of murein. http://togogenome.org/gene/535712:A4Z71_RS02250 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYF6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS02280 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE0 ^@ Similarity ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/535712:A4Z71_RS03310 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYX4 ^@ Caution|||Function|||Similarity ^@ Belongs to the dUTPase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/535712:A4Z71_RS00385 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXI3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS04155 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurCDEF family.|||Cell wall formation. Catalyzes the addition of glutamate to the nucleotide precursor UDP-N-acetylmuramoyl-L-alanine (UMA).|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04800 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS00420 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXJ4 ^@ Cofactor ^@ Binds 2 Zn(2+) ions per subunit. One is catalytic and the other provides a structural contribution. http://togogenome.org/gene/535712:A4Z71_RS04600 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL3 ^@ Similarity ^@ Belongs to the ribF family. http://togogenome.org/gene/535712:A4Z71_RS02295 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0X3 ^@ Function|||Similarity ^@ Belongs to the helicase family. RecG subfamily.|||Critical role in recombination and DNA repair. Helps process Holliday junction intermediates to mature products by catalyzing branch migration. Has a DNA unwinding activity characteristic of a DNA helicase with a 3'- to 5'- polarity. Unwinds branched duplex DNA (Y-DNA). http://togogenome.org/gene/535712:A4Z71_RS03445 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ16 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecF subfamily.|||Cell membrane|||Forms a complex with SecD. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/535712:A4Z71_RS04935 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR4 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/535712:A4Z71_RS01765 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY83 ^@ Similarity ^@ Belongs to the YciI family. http://togogenome.org/gene/535712:A4Z71_RS01510 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY45 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/535712:A4Z71_RS00040 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXB0 ^@ Function|||Similarity ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two reactions in de novo purine nucleotide biosynthesis. Catalyzes the breakdown of 5-aminoimidazole- (N-succinylocarboxamide) ribotide (SAICAR or 2-[5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamido]succinate) to 5-aminoimidazole-4-carboxamide ribotide (AICAR or 5-amino-1-(5-phospho-beta-D-ribosyl)imidazole-4-carboxamide) and fumarate, and of adenylosuccinate (ADS or N(6)-(1,2-dicarboxyethyl)-AMP) to adenosine monophosphate (AMP) and fumarate. http://togogenome.org/gene/535712:A4Z71_RS04645 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RbfA family.|||Cytoplasm|||Monomer. Binds 30S ribosomal subunits, but not 50S ribosomal subunits or 70S ribosomes.|||One of several proteins that assist in the late maturation steps of the functional core of the 30S ribosomal subunit. Associates with free 30S ribosomal subunits (but not with 30S subunits that are part of 70S ribosomes or polysomes). Required for efficient processing of 16S rRNA. May interact with the 5'-terminal helix region of 16S rRNA. http://togogenome.org/gene/535712:A4Z71_RS05870 ^@ http://purl.uniprot.org/uniprot/A0A1D9E087 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL30 family.|||Part of the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS06840 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0P8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecF family.|||Cytoplasm|||The RecF protein is involved in DNA metabolism; it is required for DNA replication and normal SOS inducibility. RecF binds preferentially to single-stranded, linear DNA. It also seems to bind ATP. http://togogenome.org/gene/535712:A4Z71_RS01095 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXV6 ^@ Function|||Similarity ^@ Belongs to the NrdI family.|||Probably involved in ribonucleotide reductase function. http://togogenome.org/gene/535712:A4Z71_RS05880 ^@ http://purl.uniprot.org/uniprot/A0A1D9E093 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL18 family.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S and 23S rRNAs.|||This is one of the proteins that binds and probably mediates the attachment of the 5S RNA into the large ribosomal subunit, where it forms part of the central protuberance. http://togogenome.org/gene/535712:A4Z71_RS06775 ^@ http://purl.uniprot.org/uniprot/A0A1D9E133 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PAL/histidase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS02360 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH8 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family.|||This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site. http://togogenome.org/gene/535712:A4Z71_RS03650 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ35 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpB family.|||Tetramer of two alpha and two beta chains.|||The beta subunit is responsible for the synthesis of L-tryptophan from indole and L-serine. http://togogenome.org/gene/535712:A4Z71_RS01975 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS03190 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Y2 ^@ Caution|||Function|||Similarity ^@ Belongs to the NAD synthetase family.|||Catalyzes the ATP-dependent amidation of deamido-NAD to form NAD. Uses L-glutamine as a nitrogen source.|||In the C-terminal section; belongs to the NAD synthetase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04475 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZI6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. HflX GTPase family.|||Cytoplasm|||GTPase that associates with the 50S ribosomal subunit and may have a role during protein synthesis or ribosome biogenesis.|||Monomer. Associates with the 50S ribosomal subunit. http://togogenome.org/gene/535712:A4Z71_RS04770 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZP1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase alpha/beta chains family.|||Cell membrane|||Produces ATP from ADP in the presence of a proton gradient across the membrane. The alpha chain is a regulatory subunit. http://togogenome.org/gene/535712:A4Z71_RS02175 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS02580 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argininosuccinate synthase family. Type 2 subfamily.|||Cytoplasm|||Homotetramer. http://togogenome.org/gene/535712:A4Z71_RS01535 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY26 ^@ Function|||PTM|||Similarity ^@ An intermediate of this reaction is the autophosphorylated ppk in which a phosphate is covalently linked to a histidine residue through a N-P bond.|||Belongs to the polyphosphate kinase 1 (PPK1) family.|||Catalyzes the reversible transfer of the terminal phosphate of ATP to form a long-chain polyphosphate (polyP). http://togogenome.org/gene/535712:A4Z71_RS05915 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL29 family. http://togogenome.org/gene/535712:A4Z71_RS06870 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0S8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OXA1/ALB3/YidC family. Type 1 subfamily.|||Interacts with the Sec translocase complex via SecD. Specifically interacts with transmembrane segments of nascent integral membrane proteins during membrane integration.|||Membrane|||Required for the insertion and/or proper folding and/or complex formation of integral membrane proteins into the membrane. Involved in integration of membrane proteins that insert both dependently and independently of the Sec translocase complex, as well as at least some lipoproteins. Aids folding of multispanning membrane proteins. http://togogenome.org/gene/535712:A4Z71_RS02830 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYQ6 ^@ Similarity ^@ Belongs to the UPF0235 family. http://togogenome.org/gene/535712:A4Z71_RS06250 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0H2 ^@ Similarity ^@ Belongs to the sigma-70 factor family. ECF subfamily. http://togogenome.org/gene/535712:A4Z71_RS05510 ^@ http://purl.uniprot.org/uniprot/A0A1D9E017 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01935 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYA6 ^@ Similarity ^@ Belongs to the peptidase A24 family. http://togogenome.org/gene/535712:A4Z71_RS04840 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. LysA subfamily.|||Homodimer.|||Specifically catalyzes the decarboxylation of meso-diaminopimelate (meso-DAP) to L-lysine. http://togogenome.org/gene/535712:A4Z71_RS05360 ^@ http://purl.uniprot.org/uniprot/A0A1D9E016 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04715 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN2 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS06845 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0R1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the beta sliding clamp family.|||Confers DNA tethering and processivity to DNA polymerases and other proteins. Acts as a clamp, forming a ring around DNA (a reaction catalyzed by the clamp-loading complex) which diffuses in an ATP-independent manner freely and bidirectionally along dsDNA. Initially characterized for its ability to contact the catalytic subunit of DNA polymerase III (Pol III), a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria; Pol III exhibits 3'-5' exonuclease proofreading activity. The beta chain is required for initiation of replication as well as for processivity of DNA replication.|||Cytoplasm|||Forms a ring-shaped head-to-tail homodimer around DNA. http://togogenome.org/gene/535712:A4Z71_RS01385 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY10 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS01755 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TerC family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS06780 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Q1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. HutI family.|||Binds 1 zinc or iron ion per subunit.|||Catalyzes the hydrolytic cleavage of the carbon-nitrogen bond in imidazolone-5-propanoate to yield N-formimidoyl-L-glutamate. It is the third step in the universal histidine degradation pathway.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03235 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYW1 ^@ Similarity ^@ Belongs to the 2-oxoacid dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS00275 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04470 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the peptidase S24 family.|||Homodimer.|||Represses a number of genes involved in the response to DNA damage (SOS response), including recA and lexA. In the presence of single-stranded DNA, RecA interacts with LexA causing an autocatalytic cleavage which disrupts the DNA-binding part of LexA, leading to derepression of the SOS regulon and eventually DNA repair. http://togogenome.org/gene/535712:A4Z71_RS01600 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY51 ^@ Caution|||Function|||Similarity ^@ Belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Bifunctional enzyme that catalyzes the formation of 4-diphosphocytidyl-2-C-methyl-D-erythritol from CTP and 2-C-methyl-D-erythritol 4-phosphate (MEP) (IspD), and catalyzes the conversion of 4-diphosphocytidyl-2-C-methyl-D-erythritol 2-phosphate (CDP-ME2P) to 2-C-methyl-D-erythritol 2,4-cyclodiphosphate (ME-CPP) with a corresponding release of cytidine 5-monophosphate (CMP) (IspF).|||In the C-terminal section; belongs to the IspF family.|||In the N-terminal section; belongs to the IspD/TarI cytidylyltransferase family. IspD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS00450 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS04100 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZB7 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase RluA family.|||Responsible for synthesis of pseudouridine from uracil. http://togogenome.org/gene/535712:A4Z71_RS02990 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYT4 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the UPP synthase family.|||Binds 2 magnesium ions per subunit.|||Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS05505 ^@ http://purl.uniprot.org/uniprot/A0A1D9E027 ^@ Function|||Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. http://togogenome.org/gene/535712:A4Z71_RS03440 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYZ8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecD/SecF family. SecD subfamily.|||Cell membrane|||Forms a complex with SecF. Part of the essential Sec protein translocation apparatus which comprises SecA, SecYEG and auxiliary proteins SecDF. Other proteins may also be involved.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Part of the Sec protein translocase complex. Interacts with the SecYEG preprotein conducting channel. SecDF uses the proton motive force (PMF) to complete protein translocation after the ATP-dependent function of SecA. http://togogenome.org/gene/535712:A4Z71_RS05860 ^@ http://purl.uniprot.org/uniprot/A0A1D9E076 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SecY/SEC61-alpha family.|||Cell membrane|||Component of the Sec protein translocase complex. Heterotrimer consisting of SecY, SecE and SecG subunits. The heterotrimers can form oligomers, although 1 heterotrimer is thought to be able to translocate proteins. Interacts with the ribosome. Interacts with SecDF, and other proteins may be involved. Interacts with SecA.|||Membrane|||The central subunit of the protein translocation channel SecYEG. Consists of two halves formed by TMs 1-5 and 6-10. These two domains form a lateral gate at the front which open onto the bilayer between TMs 2 and 7, and are clamped together by SecE at the back. The channel is closed by both a pore ring composed of hydrophobic SecY resides and a short helix (helix 2A) on the extracellular side of the membrane which forms a plug. The plug probably moves laterally to allow the channel to open. The ring and the pore may move independently. http://togogenome.org/gene/535712:A4Z71_RS01795 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0W2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. RsmA subfamily.|||Cytoplasm|||Specifically dimethylates two adjacent adenosines (A1518 and A1519) in the loop of a conserved hairpin near the 3'-end of 16S rRNA in the 30S particle. May play a critical role in biogenesis of 30S subunits. http://togogenome.org/gene/535712:A4Z71_RS00605 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXM0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS00955 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXU0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL1 family.|||Binds directly to 23S rRNA. The L1 stalk is quite mobile in the ribosome, and is involved in E site tRNA release.|||Part of the 50S ribosomal subunit.|||Protein L1 is also a translational repressor protein, it controls the translation of the L11 operon by binding to its mRNA. http://togogenome.org/gene/535712:A4Z71_RS06320 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0G6 ^@ Similarity ^@ Belongs to the PEP-utilizing enzyme family. http://togogenome.org/gene/535712:A4Z71_RS01785 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY78 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. MetG type 2A subfamily.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Is required not only for elongation of protein synthesis but also for the initiation of all mRNA translation through initiator tRNA(fMet) aminoacylation.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS06855 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0S3 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL34 family. http://togogenome.org/gene/535712:A4Z71_RS02320 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYG8 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the FPG family.|||Binds 1 zinc ion per subunit.|||Involved in base excision repair of DNA damaged by oxidation or by mutagenic agents. Acts as DNA glycosylase that recognizes and removes damaged bases. Has a preference for oxidized purines, such as 7,8-dihydro-8-oxoguanine (8-oxoG). Has AP (apurinic/apyrimidinic) lyase activity and introduces nicks in the DNA strand. Cleaves the DNA backbone by beta-delta elimination to generate a single-strand break at the site of the removed base with both 3'- and 5'-phosphates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS06590 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0M6 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/535712:A4Z71_RS04405 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phenylalanyl-tRNA synthetase beta subunit family. Type 1 subfamily.|||Binds 2 magnesium ions per tetramer.|||Cytoplasm|||Tetramer of two alpha and two beta subunits. http://togogenome.org/gene/535712:A4Z71_RS05395 ^@ http://purl.uniprot.org/uniprot/A0A1D9E010 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. http://togogenome.org/gene/535712:A4Z71_RS00795 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXQ4 ^@ Caution|||Function|||Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. MenB subfamily.|||Converts o-succinylbenzoyl-CoA (OSB-CoA) to 1,4-dihydroxy-2-naphthoyl-CoA (DHNA-CoA).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS00815 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXQ1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03205 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV4 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/535712:A4Z71_RS00640 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the purine/pyrimidine phosphoribosyltransferase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03665 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ53 ^@ Similarity ^@ Belongs to the glutamate synthase family. http://togogenome.org/gene/535712:A4Z71_RS04865 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RNase PH family.|||Homohexameric ring arranged as a trimer of dimers.|||Phosphorolytic 3'-5' exoribonuclease that plays an important role in tRNA 3'-end maturation. Removes nucleotide residues following the 3'-CCA terminus of tRNAs; can also add nucleotides to the ends of RNA molecules by using nucleoside diphosphates as substrates, but this may not be physiologically important. Probably plays a role in initiation of 16S rRNA degradation (leading to ribosome degradation) during starvation. http://togogenome.org/gene/535712:A4Z71_RS04625 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZM7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family. CysTW subfamily.|||Cell membrane|||Membrane|||Part of the binding-protein-dependent transport system for phosphate; probably responsible for the translocation of the substrate across the membrane. http://togogenome.org/gene/535712:A4Z71_RS02405 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS2 family. http://togogenome.org/gene/535712:A4Z71_RS04490 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZJ7 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the IPP transferase family.|||Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 in tRNAs that read codons beginning with uridine, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A).|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS03530 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ22 ^@ Function|||Similarity ^@ Belongs to the NusB family.|||Involved in transcription antitermination. Required for transcription of ribosomal RNA (rRNA) genes. Binds specifically to the boxA antiterminator sequence of the ribosomal RNA (rrn) operons. http://togogenome.org/gene/535712:A4Z71_RS02005 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB3 ^@ Function|||Similarity ^@ ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily. http://togogenome.org/gene/535712:A4Z71_RS03395 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ07 ^@ Caution|||Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05955 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL3 family.|||One of the primary rRNA binding proteins, it binds directly near the 3'-end of the 23S rRNA, where it nucleates assembly of the 50S subunit.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L14 and L19. http://togogenome.org/gene/535712:A4Z71_RS05050 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the LeuD family. LeuD type 1 subfamily.|||Catalyzes the isomerization between 2-isopropylmalate and 3-isopropylmalate, via the formation of 2-isopropylmaleate.|||Heterodimer of LeuC and LeuD. http://togogenome.org/gene/535712:A4Z71_RS02965 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endoribonuclease YbeY family.|||Binds 1 zinc ion.|||Cytoplasm|||Single strand-specific metallo-endoribonuclease involved in late-stage 70S ribosome quality control and in maturation of the 3' terminus of the 16S rRNA. http://togogenome.org/gene/535712:A4Z71_RS05480 ^@ http://purl.uniprot.org/uniprot/A0A1D9E000 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/535712:A4Z71_RS03740 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ60 ^@ Similarity ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS02645 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL1 ^@ Function|||Similarity ^@ Belongs to the MsrA Met sulfoxide reductase family.|||Has an important function as a repair enzyme for proteins that have been inactivated by oxidation. Catalyzes the reversible oxidation-reduction of methionine sulfoxide in proteins to methionine. http://togogenome.org/gene/535712:A4Z71_RS05780 ^@ http://purl.uniprot.org/uniprot/A0A1D9E135 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TsaE family.|||Cytoplasm|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. Is involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37, together with TsaD and TsaB. TsaE seems to play an indirect role in the t(6)A biosynthesis pathway, possibly in regulating the core enzymatic function of TsaD. http://togogenome.org/gene/535712:A4Z71_RS00710 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXN8 ^@ Domain|||Function|||Similarity ^@ Belongs to the RecA family. RadA subfamily.|||DNA-dependent ATPase involved in processing of recombination intermediates, plays a role in repairing DNA breaks. Stimulates the branch migration of RecA-mediated strand transfer reactions, allowing the 3' invading strand to extend heteroduplex DNA faster. Binds ssDNA in the presence of ADP but not other nucleotides, has ATPase activity that is stimulated by ssDNA and various branched DNA structures, but inhibited by SSB. Does not have RecA's homology-searching function.|||Plays a role in repairing double-strand DNA breaks, probably involving stabilizing or processing branched DNA or blocked replication forks.|||The middle region has homology to RecA with ATPase motifs including the RadA KNRFG motif, while the C-terminus is homologous to Lon protease. http://togogenome.org/gene/535712:A4Z71_RS05605 ^@ http://purl.uniprot.org/uniprot/A0A1D9E029 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS01080 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family. ZupT subfamily.|||Cell membrane|||Mediates zinc uptake. May also transport other divalent cations.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02575 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL5 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/535712:A4Z71_RS01990 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC7 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/535712:A4Z71_RS06510 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0K2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05690 ^@ http://purl.uniprot.org/uniprot/A0A1D9E074 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/535712:A4Z71_RS02780 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYP4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL21 family.|||Part of the 50S ribosomal subunit. Contacts protein L20.|||This protein binds to 23S rRNA in the presence of protein L20. http://togogenome.org/gene/535712:A4Z71_RS05350 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZZ4 ^@ Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS03115 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYU2 ^@ Similarity ^@ Belongs to the fabD family. http://togogenome.org/gene/535712:A4Z71_RS04830 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ0 ^@ Function|||Similarity ^@ Belongs to the threonine synthase family.|||Catalyzes the gamma-elimination of phosphate from L-phosphohomoserine and the beta-addition of water to produce L-threonine. http://togogenome.org/gene/535712:A4Z71_RS05905 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL14 family.|||Binds to 23S rRNA. Forms part of two intersubunit bridges in the 70S ribosome.|||Part of the 50S ribosomal subunit. Forms a cluster with proteins L3 and L19. In the 70S ribosome, L14 and L19 interact and together make contacts with the 16S rRNA in bridges B5 and B8. http://togogenome.org/gene/535712:A4Z71_RS01605 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY47 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS02365 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S26 family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS00080 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-3 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04570 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZL8 ^@ Similarity ^@ Belongs to the DapB family. http://togogenome.org/gene/535712:A4Z71_RS03510 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ27 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the shikimate kinase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the specific phosphorylation of the 3-hydroxyl group of shikimic acid using ATP as a cosubstrate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS05680 ^@ http://purl.uniprot.org/uniprot/A0A1D9E073 ^@ Function|||Similarity|||Subunit ^@ Belongs to the succinate/malate CoA ligase alpha subunit family.|||Heterotetramer of two alpha and two beta subunits.|||Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. http://togogenome.org/gene/535712:A4Z71_RS05890 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||One of the primary rRNA binding proteins, it binds directly to 16S rRNA central domain where it helps coordinate assembly of the platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S5 and S12. http://togogenome.org/gene/535712:A4Z71_RS05175 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZW1 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the IlvD/Edd family.|||Binds 1 [2Fe-2S] cluster per subunit. This cluster acts as a Lewis acid cofactor.|||Functions in the biosynthesis of branched-chain amino acids. Catalyzes the dehydration of (2R,3R)-2,3-dihydroxy-3-methylpentanoate (2,3-dihydroxy-3-methylvalerate) into 2-oxo-3-methylpentanoate (2-oxo-3-methylvalerate) and of (2R)-2,3-dihydroxy-3-methylbutanoate (2,3-dihydroxyisovalerate) into 2-oxo-3-methylbutanoate (2-oxoisovalerate), the penultimate precursor to L-isoleucine and L-valine, respectively.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04420 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH6 ^@ Function|||Similarity ^@ Belongs to the bacterial ribosomal protein bL20 family.|||Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit. http://togogenome.org/gene/535712:A4Z71_RS02790 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An essential GTPase which binds GTP, GDP and possibly (p)ppGpp with moderate affinity, with high nucleotide exchange rates and a fairly low GTP hydrolysis rate. Plays a role in control of the cell cycle, stress response, ribosome biogenesis and in those bacteria that undergo differentiation, in morphogenesis control.|||Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS02520 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYK6 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatB/GatE family. GatB subfamily.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/535712:A4Z71_RS01125 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS05385 ^@ http://purl.uniprot.org/uniprot/A0A1D9E004 ^@ Similarity ^@ Belongs to the CDP-glycerol glycerophosphotransferase family. http://togogenome.org/gene/535712:A4Z71_RS03780 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ99 ^@ Similarity ^@ Belongs to the GPI family. http://togogenome.org/gene/535712:A4Z71_RS05415 ^@ http://purl.uniprot.org/uniprot/A0A1D9E042 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the PurK/PurT family.|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)- to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05475 ^@ http://purl.uniprot.org/uniprot/A0A1D9E034 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PNP/MTAP phosphorylase family.|||Homotrimer.|||The purine nucleoside phosphorylases catalyze the phosphorolytic breakdown of the N-glycosidic bond in the beta-(deoxy)ribonucleoside molecules, with the formation of the corresponding free purine bases and pentose-1-phosphate. Cleaves guanosine, inosine, 2'-deoxyguanosine and 2'-deoxyinosine. http://togogenome.org/gene/535712:A4Z71_RS03450 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ37 ^@ Function|||Similarity ^@ Belongs to the relA/spoT family.|||In eubacteria ppGpp (guanosine 3'-diphosphate 5'-diphosphate) is a mediator of the stringent response that coordinates a variety of cellular activities in response to changes in nutritional abundance. http://togogenome.org/gene/535712:A4Z71_RS06105 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0D2 ^@ Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the cytidine and deoxycytidylate deaminase family.|||Binds 1 zinc ion per subunit.|||Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2).|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS05930 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0B1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL22 family.|||Part of the 50S ribosomal subunit.|||The globular domain of the protein is located near the polypeptide exit tunnel on the outside of the subunit, while an extended beta-hairpin is found that lines the wall of the exit tunnel in the center of the 70S ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g. L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome.|||This protein binds specifically to 23S rRNA; its binding is stimulated by other ribosomal proteins, e.g., L4, L17, and L20. It is important during the early stages of 50S assembly. It makes multiple contacts with different domains of the 23S rRNA in the assembled 50S subunit and ribosome. http://togogenome.org/gene/535712:A4Z71_RS04330 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZF6 ^@ Activity Regulation|||Caution|||Function|||Miscellaneous|||Similarity|||Subunit ^@ Allosterically activated by GTP, when glutamine is the substrate; GTP has no effect on the reaction when ammonia is the substrate. The allosteric effector GTP functions by stabilizing the protein conformation that binds the tetrahedral intermediate(s) formed during glutamine hydrolysis. Inhibited by the product CTP, via allosteric rather than competitive inhibition.|||Belongs to the CTP synthase family.|||CTPSs have evolved a hybrid strategy for distinguishing between UTP and CTP. The overlapping regions of the product feedback inhibitory and substrate sites recognize a common feature in both compounds, the triphosphate moiety. To differentiate isosteric substrate and product pyrimidine rings, an additional pocket far from the expected kinase/ligase catalytic site, specifically recognizes the cytosine and ribose portions of the product inhibitor.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02345 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ A probable RNA-binding protein.|||Belongs to the KhpA RNA-binding protein family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06860 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Q7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the RnpA family.|||Consists of a catalytic RNA component (M1 or rnpB) and a protein subunit.|||RNaseP catalyzes the removal of the 5'-leader sequence from pre-tRNA to produce the mature 5'-terminus. It can also cleave other RNA substrates such as 4.5S RNA. The protein component plays an auxiliary but essential role in vivo by binding to the 5'-leader sequence and broadening the substrate specificity of the ribozyme. http://togogenome.org/gene/535712:A4Z71_RS06825 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0U3 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner.|||Belongs to the topoisomerase GyrA/ParC subunit family.|||Belongs to the type II topoisomerase GyrA/ParC subunit family.|||Cytoplasm|||Few gyrases are as efficient as E.coli at forming negative supercoils. Not all organisms have 2 type II topoisomerases; in organisms with a single type II topoisomerase this enzyme also has to decatenate newly replicated chromosomes.|||Heterotetramer, composed of two GyrA and two GyrB chains. In the heterotetramer, GyrA contains the active site tyrosine that forms a transient covalent intermediate with DNA, while GyrB binds cofactors and catalyzes ATP hydrolysis. http://togogenome.org/gene/535712:A4Z71_RS01730 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY55 ^@ Similarity ^@ Belongs to the 5-formyltetrahydrofolate cyclo-ligase family. http://togogenome.org/gene/535712:A4Z71_RS02485 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/535712:A4Z71_RS00925 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MurB family.|||Cell wall formation.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS02795 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYQ2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate 5-kinase family.|||Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS04835 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS1 ^@ Similarity ^@ Belongs to the homoserine dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS01835 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY95 ^@ Function|||Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL25 family. CTC subfamily.|||Part of the 50S ribosomal subunit; part of the 5S rRNA/L5/L18/L25 subcomplex. Contacts the 5S rRNA. Binds to the 5S rRNA independently of L5 and L18.|||This is one of the proteins that binds to the 5S RNA in the ribosome where it forms part of the central protuberance. http://togogenome.org/gene/535712:A4Z71_RS00460 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXK7 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/535712:A4Z71_RS04460 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZM2 ^@ Similarity|||Subunit ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. Histidinol-phosphate aminotransferase subfamily.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS04215 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZH9 ^@ Similarity ^@ Belongs to the class-II DAHP synthase family. http://togogenome.org/gene/535712:A4Z71_RS02800 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYN8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyl phosphate reductase family.|||Catalyzes the NADPH-dependent reduction of L-glutamate 5-phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06100 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0E1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04725 ^@ http://purl.uniprot.org/uniprot/A0A1D9E111 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/535712:A4Z71_RS02945 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYR5 ^@ Caution|||Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DnaJ family.|||Binds 2 Zn(2+) ions per monomer.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and GrpE are required for fully efficient folding. Also involved, together with DnaK and GrpE, in the DNA replication of plasmids through activation of initiation proteins.|||The J domain is necessary and sufficient to stimulate DnaK ATPase activity. Zinc center 1 plays an important role in the autonomous, DnaK-independent chaperone activity of DnaJ. Zinc center 2 is essential for interaction with DnaK and for DnaJ activity. http://togogenome.org/gene/535712:A4Z71_RS00860 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXR8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS05550 ^@ http://purl.uniprot.org/uniprot/A0A1D9E033 ^@ Cofactor|||Similarity ^@ Belongs to the succinate dehydrogenase/fumarate reductase iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster.|||Binds 1 [3Fe-4S] cluster.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/535712:A4Z71_RS04965 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT7 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/535712:A4Z71_RS05810 ^@ http://purl.uniprot.org/uniprot/A0A1D9E062 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/535712:A4Z71_RS03495 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ06 ^@ Function|||Similarity ^@ Belongs to the transglycosylase MltG family.|||Functions as a peptidoglycan terminase that cleaves nascent peptidoglycan strands endolytically to terminate their elongation. http://togogenome.org/gene/535712:A4Z71_RS05655 ^@ http://purl.uniprot.org/uniprot/A0A1D9E053 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/535712:A4Z71_RS04640 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZK4 ^@ Function|||Similarity ^@ Belongs to the pseudouridine synthase TruB family. Type 1 subfamily.|||Responsible for synthesis of pseudouridine from uracil-55 in the psi GC loop of transfer RNAs. http://togogenome.org/gene/535712:A4Z71_RS03385 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Z0 ^@ Similarity ^@ Belongs to the MQO family. http://togogenome.org/gene/535712:A4Z71_RS07030 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZW6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. NadB subfamily.|||Catalyzes the oxidation of L-aspartate to iminoaspartate, the first step in the de novo biosynthesis of NAD(+).|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03925 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ84 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Bacitracin is thought to be involved in the inhibition of peptidoglycan synthesis by sequestering undecaprenyl diphosphate, thereby reducing the pool of lipid carrier available.|||Belongs to the UppP family.|||Catalyzes the dephosphorylation of undecaprenyl diphosphate (UPP). Confers resistance to bacitracin.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04075 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Y9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor.|||Cell membrane|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS05755 ^@ http://purl.uniprot.org/uniprot/A0A1D9E067 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GroES chaperonin family.|||Cytoplasm|||Heptamer of 7 subunits arranged in a ring. Interacts with the chaperonin GroEL.|||Together with the chaperonin GroEL, plays an essential role in assisting protein folding. The GroEL-GroES system forms a nano-cage that allows encapsulation of the non-native substrate proteins and provides a physical environment optimized to promote and accelerate protein folding. GroES binds to the apical surface of the GroEL ring, thereby capping the opening of the GroEL channel. http://togogenome.org/gene/535712:A4Z71_RS02135 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE3 ^@ Similarity ^@ Belongs to the trans-sulfuration enzymes family. http://togogenome.org/gene/535712:A4Z71_RS01825 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY91 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family. Class I subfamily.|||Binds 2 Mg(2+) ions per subunit.|||Cytoplasm|||Homohexamer.|||Involved in the biosynthesis of the central metabolite phospho-alpha-D-ribosyl-1-pyrophosphate (PRPP) via the transfer of pyrophosphoryl group from ATP to 1-hydroxyl of ribose-5-phosphate (Rib-5-P). http://togogenome.org/gene/535712:A4Z71_RS03720 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ48 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UvrC family.|||Cytoplasm|||Interacts with UvrB in an incision complex.|||The UvrABC repair system catalyzes the recognition and processing of DNA lesions. UvrC both incises the 5' and 3' sides of the lesion. The N-terminal half is responsible for the 3' incision and the C-terminal half is responsible for the 5' incision. http://togogenome.org/gene/535712:A4Z71_RS03180 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PanB family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha-ketoisovalerate to form ketopantoate.|||Cytoplasm|||Homodecamer; pentamer of dimers. http://togogenome.org/gene/535712:A4Z71_RS00785 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXP6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS06935 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0U2 ^@ Similarity ^@ Belongs to the Nudix hydrolase family. http://togogenome.org/gene/535712:A4Z71_RS04845 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZS0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class-I aminoacyl-tRNA synthetase family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS00110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS06390 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS03970 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TatC family.|||Cell membrane|||Membrane|||Part of the twin-arginine translocation (Tat) system that transports large folded proteins containing a characteristic twin-arginine motif in their signal peptide across membranes. Together with TatB, TatC is part of a receptor directly interacting with Tat signal peptides.|||The Tat system comprises two distinct complexes: a TatABC complex, containing multiple copies of TatA, TatB and TatC subunits, and a separate TatA complex, containing only TatA subunits. Substrates initially bind to the TatABC complex, which probably triggers association of the separate TatA complex to form the active translocon. http://togogenome.org/gene/535712:A4Z71_RS02070 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYB1 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/535712:A4Z71_RS03540 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ21 ^@ Similarity ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. http://togogenome.org/gene/535712:A4Z71_RS02530 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYK3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 3'-to-5' exoribonuclease specific for small oligoribonucleotides.|||Belongs to the oligoribonuclease family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS00100 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS14 family.|||Binds 16S rRNA, required for the assembly of 30S particles and may also be responsible for determining the conformation of the 16S rRNA at the A site.|||Part of the 30S ribosomal subunit. Contacts proteins S3 and S10. http://togogenome.org/gene/535712:A4Z71_RS01650 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY44 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS03825 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ81 ^@ Similarity ^@ Belongs to the ABC transporter superfamily. Ycf16 family. http://togogenome.org/gene/535712:A4Z71_RS02385 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI1 ^@ Similarity ^@ Belongs to the Mg-chelatase subunits D/I family. ComM subfamily. http://togogenome.org/gene/535712:A4Z71_RS04990 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU0 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/535712:A4Z71_RS03245 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYW9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M17 family.|||Binds 2 manganese ions per subunit.|||Cytoplasm|||Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N-terminal amino acids from various peptides. http://togogenome.org/gene/535712:A4Z71_RS00150 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXE7 ^@ Similarity ^@ Belongs to the BlaI transcriptional regulatory family. http://togogenome.org/gene/535712:A4Z71_RS03695 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ50 ^@ Function|||Similarity ^@ Belongs to the DNA polymerase type-A family.|||In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity. http://togogenome.org/gene/535712:A4Z71_RS01345 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY03 ^@ Function|||Similarity ^@ Belongs to the thymidylate kinase family.|||Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis. http://togogenome.org/gene/535712:A4Z71_RS05405 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZZ8 ^@ Similarity ^@ Belongs to the LytR/CpsA/Psr (LCP) family. http://togogenome.org/gene/535712:A4Z71_RS05515 ^@ http://purl.uniprot.org/uniprot/A0A1D9E020 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS03870 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ83 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/535712:A4Z71_RS02130 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. MetX family.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Transfers an acetyl group from acetyl-CoA to L-homoserine, forming acetyl-L-homoserine. http://togogenome.org/gene/535712:A4Z71_RS05750 ^@ http://purl.uniprot.org/uniprot/A0A1D9E050 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EamA transporter family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS04145 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZD7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 28 family. MurG subfamily.|||Cell membrane|||Cell wall formation. Catalyzes the transfer of a GlcNAc subunit on undecaprenyl-pyrophosphoryl-MurNAc-pentapeptide (lipid intermediate I) to form undecaprenyl-pyrophosphoryl-MurNAc-(pentapeptide)GlcNAc (lipid intermediate II).|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS00560 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIR synthase family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS01690 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0Z6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS04125 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZC3 ^@ Function|||Similarity ^@ Belongs to the pyridoxal phosphate-binding protein YggS/PROSC family.|||Pyridoxal 5'-phosphate (PLP)-binding protein, which is involved in PLP homeostasis. http://togogenome.org/gene/535712:A4Z71_RS03755 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SecG family.|||Cell membrane|||Involved in protein export. Participates in an early event of protein translocation.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS06895 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0R0 ^@ Similarity ^@ Belongs to the ParB family. http://togogenome.org/gene/535712:A4Z71_RS04700 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ABC transporter superfamily. Spermidine/putrescine importer (TC 3.A.1.11.1) family.|||Part of the ABC transporter complex PotABCD involved in spermidine/putrescine import. Responsible for energy coupling to the transport system.|||The complex is composed of two ATP-binding proteins (PotA), two transmembrane proteins (PotB and PotC) and a solute-binding protein (PotD). http://togogenome.org/gene/535712:A4Z71_RS05190 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZX8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS05835 ^@ http://purl.uniprot.org/uniprot/A0A1D9E079 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS11 family.|||Located on the platform of the 30S subunit, it bridges several disparate RNA helices of the 16S rRNA. Forms part of the Shine-Dalgarno cleft in the 70S ribosome.|||Part of the 30S ribosomal subunit. Interacts with proteins S7 and S18. Binds to IF-3. http://togogenome.org/gene/535712:A4Z71_RS04270 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS05170 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZW9 ^@ Cofactor|||Similarity ^@ Belongs to the TPP enzyme family.|||Binds 1 Mg(2+) ion per subunit.|||Binds 1 thiamine pyrophosphate per subunit. http://togogenome.org/gene/535712:A4Z71_RS02350 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYH4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ An accessory protein needed during the final step in the assembly of 30S ribosomal subunit, possibly for assembly of the head region. Probably interacts with S19. Essential for efficient processing of 16S rRNA. May be needed both before and after RbfA during the maturation of 16S rRNA. It has affinity for free ribosomal 30S subunits but not for 70S ribosomes.|||Belongs to the RimM family.|||Binds ribosomal protein S19.|||Cytoplasm|||The PRC barrel domain binds ribosomal protein S19. http://togogenome.org/gene/535712:A4Z71_RS00260 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXG3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylosuccinate synthetase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Homodimer.|||Plays an important role in the de novo pathway of purine nucleotide biosynthesis. Catalyzes the first committed step in the biosynthesis of AMP from IMP. http://togogenome.org/gene/535712:A4Z71_RS01100 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXV2 ^@ Function|||Similarity ^@ Belongs to the glutaredoxin family.|||Electron transport system for the ribonucleotide reductase system NrdEF. http://togogenome.org/gene/535712:A4Z71_RS02015 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC1 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/535712:A4Z71_RS03070 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the binding-protein-dependent transport system permease family.|||Cell membrane http://togogenome.org/gene/535712:A4Z71_RS00510 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXL6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Part of the FGAM synthase complex composed of 1 PurL, 1 PurQ and 2 PurS subunits.|||Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP-dependent manner. PurS interacts with PurQ and PurL and is thought to assist in the transfer of the ammonia molecule from PurQ to PurL. http://togogenome.org/gene/535712:A4Z71_RS01260 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXY6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS01340 ^@ http://purl.uniprot.org/uniprot/A0A1D9DY01 ^@ Caution|||Function|||Similarity|||Subunit ^@ Belongs to the type IA topoisomerase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer.|||Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supercoils. Finally, in the religation step, the DNA 3'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/535712:A4Z71_RS03110 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYV3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the thiolase-like superfamily. FabH family.|||Catalyzes the condensation reaction of fatty acid synthesis by the addition to an acyl acceptor of two carbons from malonyl-ACP. Catalyzes the first condensation reaction which initiates fatty acid synthesis and may therefore play a role in governing the total rate of fatty acid production. Possesses both acetoacetyl-ACP synthase and acetyl transacylase activities. Its substrate specificity determines the biosynthesis of branched-chain and/or straight-chain of fatty acids.|||Cytoplasm|||Homodimer.|||The last Arg residue of the ACP-binding site is essential for the weak association between ACP/AcpP and FabH. http://togogenome.org/gene/535712:A4Z71_RS05400 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC-2 integral membrane protein family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS00310 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXH2 ^@ Similarity ^@ Belongs to the gluconokinase GntK/GntV family. http://togogenome.org/gene/535712:A4Z71_RS02170 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYE5 ^@ Similarity ^@ Belongs to the GSP E family. http://togogenome.org/gene/535712:A4Z71_RS05815 ^@ http://purl.uniprot.org/uniprot/A0A1D9E077 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uL13 family.|||Part of the 50S ribosomal subunit.|||This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly. http://togogenome.org/gene/535712:A4Z71_RS00200 ^@ http://purl.uniprot.org/uniprot/A0A1D9DXF2 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus membrane http://togogenome.org/gene/535712:A4Z71_RS05630 ^@ http://purl.uniprot.org/uniprot/A0A1D9E064 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the tryptophan 2,3-dioxygenase family.|||Binds 1 heme group per subunit.|||Heme-dependent dioxygenase that catalyzes the oxidative cleavage of the L-tryptophan (L-Trp) pyrrole ring and converts L-tryptophan to N-formyl-L-kynurenine. Catalyzes the oxidative cleavage of the indole moiety.|||Homotetramer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS02510 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYL2 ^@ Function|||Similarity|||Subunit ^@ Allows the formation of correctly charged Asn-tRNA(Asn) or Gln-tRNA(Gln) through the transamidation of misacylated Asp-tRNA(Asn) or Glu-tRNA(Gln) in organisms which lack either or both of asparaginyl-tRNA or glutaminyl-tRNA synthetases. The reaction takes place in the presence of glutamine and ATP through an activated phospho-Asp-tRNA(Asn) or phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Heterotrimer of A, B and C subunits. http://togogenome.org/gene/535712:A4Z71_RS03610 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA-PH family.|||Cytoplasm http://togogenome.org/gene/535712:A4Z71_RS06850 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0R2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DnaA family.|||Cytoplasm|||Plays an important role in the initiation and regulation of chromosomal replication. Binds to the origin of replication; it binds specifically double-stranded DNA at a 9 bp consensus (dnaA box): 5'-TTATC[CA]A[CA]A-3'. DnaA binds to ATP and to acidic phospholipids. http://togogenome.org/gene/535712:A4Z71_RS06495 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0J9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ferrochelatase family.|||Cytoplasm|||Involved in coproporphyrin-dependent heme b biosynthesis. Catalyzes the insertion of ferrous iron into coproporphyrin III to form Fe-coproporphyrin III.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS06060 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0D4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS12 family.|||Interacts with and stabilizes bases of the 16S rRNA that are involved in tRNA selection in the A site and with the mRNA backbone. Located at the interface of the 30S and 50S subunits, it traverses the body of the 30S subunit contacting proteins on the other side and probably holding the rRNA structure together. The combined cluster of proteins S8, S12 and S17 appears to hold together the shoulder and platform of the 30S subunit.|||Part of the 30S ribosomal subunit. Contacts proteins S8 and S17. May interact with IF1 in the 30S initiation complex.|||With S4 and S5 plays an important role in translational accuracy. http://togogenome.org/gene/535712:A4Z71_RS06655 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0N6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/535712:A4Z71_RS04685 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZN8 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/535712:A4Z71_RS04860 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZQ6 ^@ Caution|||Cofactor|||Function|||Similarity|||Subunit ^@ Belongs to the HAM1 NTPase family.|||Binds 1 Mg(2+) ion per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. http://togogenome.org/gene/535712:A4Z71_RS02150 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYC9 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/535712:A4Z71_RS05855 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0A3 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/535712:A4Z71_RS03655 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ34 ^@ Function|||Similarity|||Subunit ^@ Belongs to the TrpA family.|||Tetramer of two alpha and two beta chains.|||The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. http://togogenome.org/gene/535712:A4Z71_RS05150 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZU1 ^@ Function|||Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Catalyzes the reversible oxidation of 3-phospho-D-glycerate to 3-phosphonooxypyruvate, the first step of the phosphorylated L-serine biosynthesis pathway. Also catalyzes the reversible oxidation of 2-hydroxyglutarate to 2-oxoglutarate. http://togogenome.org/gene/535712:A4Z71_RS05825 ^@ http://purl.uniprot.org/uniprot/A0A1D9E066 ^@ Similarity|||Subunit ^@ Belongs to the bacterial ribosomal protein bL17 family.|||Part of the 50S ribosomal subunit. Contacts protein L32. http://togogenome.org/gene/535712:A4Z71_RS04930 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZR8 ^@ Similarity ^@ Belongs to the helicase family. UvrD subfamily. http://togogenome.org/gene/535712:A4Z71_RS05320 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZX2 ^@ Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenosylhomocysteinase family.|||Binds 1 NAD(+) per subunit.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine. http://togogenome.org/gene/535712:A4Z71_RS04785 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase C chain family.|||Cell membrane|||F(1)F(0) ATP synthase produces ATP from ADP in the presence of a proton or sodium gradient. F-type ATPases consist of two structural domains, F(1) containing the extramembraneous catalytic core and F(0) containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation.|||Key component of the F(0) channel; it plays a direct role in translocation across the membrane. A homomeric c-ring of between 10-14 subunits forms the central stalk rotor element with the F(1) delta and epsilon subunits.|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02395 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYI5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 'phage' integrase family. XerC subfamily.|||Cytoplasm|||Forms a cyclic heterotetrameric complex composed of two molecules of XerC and two molecules of XerD.|||Site-specific tyrosine recombinase, which acts by catalyzing the cutting and rejoining of the recombining DNA molecules. The XerC-XerD complex is essential to convert dimers of the bacterial chromosome into monomers to permit their segregation at cell division. It also contributes to the segregational stability of plasmids. http://togogenome.org/gene/535712:A4Z71_RS02765 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYP6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/535712:A4Z71_RS06180 ^@ http://purl.uniprot.org/uniprot/A0A1D9E0I0 ^@ Similarity ^@ Belongs to the DegT/DnrJ/EryC1 family. http://togogenome.org/gene/535712:A4Z71_RS05795 ^@ http://purl.uniprot.org/uniprot/A0A1D9E092 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Catalyzes the first step in hexosamine metabolism, converting fructose-6P into glucosamine-6P using glutamine as a nitrogen source.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/535712:A4Z71_RS05560 ^@ http://purl.uniprot.org/uniprot/A0A1D9E038 ^@ Similarity ^@ Belongs to the DNA repair enzymes AP/ExoA family. http://togogenome.org/gene/535712:A4Z71_RS04015 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/535712:A4Z71_RS02985 ^@ http://purl.uniprot.org/uniprot/A0A1D9DYT8 ^@ Function|||Similarity ^@ Belongs to the RecO family.|||Involved in DNA repair and RecF pathway recombination. http://togogenome.org/gene/535712:A4Z71_RS03580 ^@ http://purl.uniprot.org/uniprot/A0A1D9DZ25 ^@ Caution|||Cofactor|||Function|||Similarity ^@ Binds 1 FMN per subunit.|||Catalyzes two sequential steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine. In the second step the latter compound is decarboxylated to form 4'-phosphopantotheine.|||Catalyzes two steps in the biosynthesis of coenzyme A. In the first step cysteine is conjugated to 4'-phosphopantothenate to form 4-phosphopantothenoylcysteine, in the latter compound is decarboxylated to form 4'-phosphopantotheine.|||In the C-terminal section; belongs to the PPC synthetase family.|||In the N-terminal section; belongs to the HFCD (homo-oligomeric flavin containing Cys decarboxylase) superfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/535712:A4Z71_RS05635 ^@ http://purl.uniprot.org/uniprot/A0A1D9E080 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family.|||Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10-methenyltetrahydrofolate to 10-formyltetrahydrofolate.|||Homodimer.