http://togogenome.org/gene/59894:ADRA2A ^@ http://purl.uniprot.org/uniprot/U3KKZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SNCA ^@ http://purl.uniprot.org/uniprot/A0A803VUP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synuclein family.|||Membrane|||Nucleus|||Secreted|||Synapse http://togogenome.org/gene/59894:E2F8 ^@ http://purl.uniprot.org/uniprot/U3JFY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/59894:LOC101821887 ^@ http://purl.uniprot.org/uniprot/A0A803VRX4|||http://purl.uniprot.org/uniprot/U3JJS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 30 family.|||Lysosome membrane http://togogenome.org/gene/59894:SLC6A15 ^@ http://purl.uniprot.org/uniprot/U3K7J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A15 subfamily.|||Membrane http://togogenome.org/gene/59894:FAM53B ^@ http://purl.uniprot.org/uniprot/A0A803VM26|||http://purl.uniprot.org/uniprot/U3JQF3 ^@ Similarity ^@ Belongs to the FAM53 family. http://togogenome.org/gene/59894:MINA ^@ http://purl.uniprot.org/uniprot/A0A803VP40 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ROX family. MINA53 subfamily.|||Binds 1 Fe(2+) ion per subunit.|||Oxygenase that can act as both a histone lysine demethylase and a ribosomal histidine hydroxylase.|||nucleolus http://togogenome.org/gene/59894:CHST8 ^@ http://purl.uniprot.org/uniprot/U3JZB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:MMAA ^@ http://purl.uniprot.org/uniprot/A0A803V5Y4 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ArgK/MeaB subfamily. http://togogenome.org/gene/59894:DHRS7C ^@ http://purl.uniprot.org/uniprot/U3JD65 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:CSF1R ^@ http://purl.uniprot.org/uniprot/U3JZS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:LZTFL1 ^@ http://purl.uniprot.org/uniprot/A0A803W5Y2|||http://purl.uniprot.org/uniprot/U3JJ17 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LZTFL1 family.|||Cytoplasm|||Regulates ciliary localization of the BBSome complex. Together with the BBSome complex, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation. May play a role in neurite outgrowth. May have tumor suppressor function.|||Self-associates. Interacts with BBS9; the interaction mediates the association of LZTL1 with the BBsome complex and regulates BBSome ciliary trafficking. http://togogenome.org/gene/59894:COQ10A ^@ http://purl.uniprot.org/uniprot/U3JCK1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/59894:SNTG1 ^@ http://purl.uniprot.org/uniprot/U3JT90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||cytoskeleton http://togogenome.org/gene/59894:NDUFV3 ^@ http://purl.uniprot.org/uniprot/U3JGZ6 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone. May be the terminally assembled subunit of Complex I.|||Belongs to the complex I NDUFV3 subunit family.|||Complex I is composed of 45 different subunits. This is a component of the flavoprotein-sulfur (FP) fragment of the enzyme. http://togogenome.org/gene/59894:NPBWR2 ^@ http://purl.uniprot.org/uniprot/U3KKL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PRDX1 ^@ http://purl.uniprot.org/uniprot/U3K4T5 ^@ Function|||Similarity ^@ Belongs to the peroxiredoxin family.|||Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. http://togogenome.org/gene/59894:KDM1B ^@ http://purl.uniprot.org/uniprot/U3KGC9 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/59894:OAZ1 ^@ http://purl.uniprot.org/uniprot/U3KH92 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/59894:LOC101806283 ^@ http://purl.uniprot.org/uniprot/U3K8F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RPF2 family.|||nucleolus http://togogenome.org/gene/59894:ERGIC2 ^@ http://purl.uniprot.org/uniprot/U3K684 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/59894:CD164L2 ^@ http://purl.uniprot.org/uniprot/A0A803VW54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD164 family.|||Membrane http://togogenome.org/gene/59894:TTC36 ^@ http://purl.uniprot.org/uniprot/U3K5S4 ^@ Similarity ^@ Belongs to the TTC36 family. http://togogenome.org/gene/59894:CDKN1B ^@ http://purl.uniprot.org/uniprot/U3JPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDI family.|||Cytoplasm|||Endosome|||Nucleus http://togogenome.org/gene/59894:ANPEP ^@ http://purl.uniprot.org/uniprot/U3K8Z9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/59894:FGFBP1 ^@ http://purl.uniprot.org/uniprot/U3KJW9 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/59894:SERPINE2 ^@ http://purl.uniprot.org/uniprot/A0A803V7Y9|||http://purl.uniprot.org/uniprot/U3JWB2 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:TAC1 ^@ http://purl.uniprot.org/uniprot/A0A803W7F8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tachykinin family.|||Secreted|||Tachykinins are active peptides which excite neurons, evoke behavioral responses, are potent vasodilators and secretagogues, and contract (directly or indirectly) many smooth muscles. http://togogenome.org/gene/59894:SMPDL3B ^@ http://purl.uniprot.org/uniprot/U3JEG8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acid sphingomyelinase family.|||Secreted http://togogenome.org/gene/59894:VAMP7 ^@ http://purl.uniprot.org/uniprot/U3KAA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/59894:SHMT1 ^@ http://purl.uniprot.org/uniprot/U3KGZ9 ^@ Function|||Similarity ^@ Belongs to the SHMT family.|||Interconversion of serine and glycine. http://togogenome.org/gene/59894:KCNG4 ^@ http://purl.uniprot.org/uniprot/U3JW55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SLC35A5 ^@ http://purl.uniprot.org/uniprot/U3JTI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/59894:MTM1 ^@ http://purl.uniprot.org/uniprot/A0A803V162|||http://purl.uniprot.org/uniprot/U3KCA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cell membrane|||Late endosome|||filopodium|||ruffle|||sarcomere http://togogenome.org/gene/59894:NPTX2 ^@ http://purl.uniprot.org/uniprot/U3KHS0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101807380 ^@ http://purl.uniprot.org/uniprot/U3KJQ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:PEX2 ^@ http://purl.uniprot.org/uniprot/U3KKL9 ^@ Function|||Similarity ^@ Belongs to the pex2/pex10/pex12 family.|||Somewhat implicated in the biogenesis of peroxisomes. http://togogenome.org/gene/59894:LOC101809122 ^@ http://purl.uniprot.org/uniprot/U3K899 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FIP1 family.|||Nucleus http://togogenome.org/gene/59894:LOC101819916 ^@ http://purl.uniprot.org/uniprot/U3K1N5 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/59894:DCK ^@ http://purl.uniprot.org/uniprot/A0A803W661 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/59894:HSD17B2 ^@ http://purl.uniprot.org/uniprot/U3JW65 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:CRH ^@ http://purl.uniprot.org/uniprot/U3JSC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sauvagine/corticotropin-releasing factor/urotensin I family.|||Secreted http://togogenome.org/gene/59894:CLDN18 ^@ http://purl.uniprot.org/uniprot/A0A803VRY0|||http://purl.uniprot.org/uniprot/A0A803W130 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:ATXN3 ^@ http://purl.uniprot.org/uniprot/A0A803V3Z4 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:ABL1 ^@ http://purl.uniprot.org/uniprot/A0A803V5V2|||http://purl.uniprot.org/uniprot/U3JFF5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:RDH10 ^@ http://purl.uniprot.org/uniprot/U3K1L0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/59894:LOC101820160 ^@ http://purl.uniprot.org/uniprot/U3K1I4 ^@ Similarity ^@ Belongs to the TASOR family. http://togogenome.org/gene/59894:INHA ^@ http://purl.uniprot.org/uniprot/U3JNX8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Dimeric, linked by one or more disulfide bonds. Inhibin A is a dimer of alpha and beta-A. Inhibin B is a dimer of alpha and beta-B.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition.|||Secreted http://togogenome.org/gene/59894:LOC107603318 ^@ http://purl.uniprot.org/uniprot/A0A803V4Z5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:NMT2 ^@ http://purl.uniprot.org/uniprot/U3JYX6 ^@ Function|||Similarity ^@ Adds a myristoyl group to the N-terminal glycine residue of certain cellular proteins.|||Belongs to the NMT family. http://togogenome.org/gene/59894:LOC101817647 ^@ http://purl.uniprot.org/uniprot/A0A803VG75 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:SLC6A19 ^@ http://purl.uniprot.org/uniprot/A0A803W386|||http://purl.uniprot.org/uniprot/U3JHH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:LOC101805674 ^@ http://purl.uniprot.org/uniprot/U3JTE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/59894:LOC101813391 ^@ http://purl.uniprot.org/uniprot/U3JXQ5 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:TAF1D ^@ http://purl.uniprot.org/uniprot/U3JBZ6 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the transcription factor SL1/TIF-IB complex, composed of TBP and at least TAF1A, TAF1B, TAF1C and TAF1D. Interacts with UBTF.|||Component of the transcription factor SL1/TIF-IB complex, which is involved in the assembly of the PIC (preinitiation complex) during RNA polymerase I-dependent transcription. The rate of PIC formation probably is primarily dependent on the rate of association of SL1/TIF-IB with the rDNA promoter. SL1/TIF-IB is involved in stabilization of nucleolar transcription factor 1/UBTF on rDNA. Formation of SL1/TIF-IB excludes the association of TBP with TFIID subunits.|||Nucleus http://togogenome.org/gene/59894:LOC101812461 ^@ http://purl.uniprot.org/uniprot/U3K436 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/59894:LOC107603574 ^@ http://purl.uniprot.org/uniprot/U3JBL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||cytoskeleton http://togogenome.org/gene/59894:CA10 ^@ http://purl.uniprot.org/uniprot/U3JDJ3 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Does not have a catalytic activity. http://togogenome.org/gene/59894:SMG8 ^@ http://purl.uniprot.org/uniprot/U3JSU5 ^@ Function|||Similarity ^@ Belongs to the SMG8 family.|||Involved in nonsense-mediated decay (NMD) of mRNAs containing premature stop codons. http://togogenome.org/gene/59894:LOC101819625 ^@ http://purl.uniprot.org/uniprot/U3JUN0 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Class-III subfamily. http://togogenome.org/gene/59894:SEC24A ^@ http://purl.uniprot.org/uniprot/U3JZS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:FABP3 ^@ http://purl.uniprot.org/uniprot/A0A803VAR7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:MYB ^@ http://purl.uniprot.org/uniprot/U3KBR6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:BROX ^@ http://purl.uniprot.org/uniprot/U3KBW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BROX family.|||Membrane http://togogenome.org/gene/59894:SNX30 ^@ http://purl.uniprot.org/uniprot/U3JBH0 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/59894:DDX24 ^@ http://purl.uniprot.org/uniprot/A0A803V145 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/59894:BRCC3 ^@ http://purl.uniprot.org/uniprot/U3KAZ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M67A family. BRCC36 subfamily.|||Binds 1 zinc ion per subunit.|||Component of the BRCA1-A complex. Component of the BRISC complex. Both the BRCA1-A complex and the BRISC complex bind polyubiquitin.|||Cytoplasm|||Metalloprotease that specifically cleaves 'Lys-63'-linked polyubiquitin chains. Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the brca1-bard1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). Catalytic subunit of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates. Mediates the specific 'Lys-63'-specific deubiquitination associated with the COP9 signalosome complex (CSN), via the interaction of the BRISC complex with the CSN complex. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1.|||Nucleus|||spindle pole http://togogenome.org/gene/59894:RBKS ^@ http://purl.uniprot.org/uniprot/U3K8E6 ^@ Activity Regulation|||Caution|||Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Activated by a monovalent cation that binds near, but not in, the active site. The most likely occupant of the site in vivo is potassium. Ion binding induces a conformational change that may alter substrate affinity.|||Belongs to the carbohydrate kinase PfkB family. Ribokinase subfamily.|||Belongs to the carbohydrate kinase pfkB family.|||Catalyzes the phosphorylation of ribose at O-5 in a reaction requiring ATP and magnesium. The resulting D-ribose-5-phosphate can then be used either for sythesis of nucleotides, histidine, and tryptophan, or as a component of the pentose phosphate pathway.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus|||Requires a divalent cation, most likely magnesium in vivo, as an electrophilic catalyst to aid phosphoryl group transfer. It is the chelate of the metal and the nucleotide that is the actual substrate. http://togogenome.org/gene/59894:PTGER4 ^@ http://purl.uniprot.org/uniprot/U3JH44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FEM1A.|||Membrane|||Receptor for prostaglandin E2 (PGE2). The activity of this receptor is mediated by G(s) proteins that stimulate adenylate cyclase. Has a relaxing effect on smooth muscle. May play an important role in regulating renal hemodynamics, intestinal epithelial transport, adrenal aldosterone secretion, and uterine function. http://togogenome.org/gene/59894:AMPD1 ^@ http://purl.uniprot.org/uniprot/A0A803W4L4|||http://purl.uniprot.org/uniprot/U3JLA7 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/59894:PRKG1 ^@ http://purl.uniprot.org/uniprot/A0A803WF94|||http://purl.uniprot.org/uniprot/U3KFF9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/59894:SLC1A7 ^@ http://purl.uniprot.org/uniprot/U3JT53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59894:SV2B ^@ http://purl.uniprot.org/uniprot/U3K737 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:HDLBP ^@ http://purl.uniprot.org/uniprot/U3JLC2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:RIOK1 ^@ http://purl.uniprot.org/uniprot/U3KFM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/59894:BRMS1L ^@ http://purl.uniprot.org/uniprot/U3JUD9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SRP54 ^@ http://purl.uniprot.org/uniprot/U3JTZ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP-binding SRP family. SRP54 subfamily.|||Component of a signal recognition particle (SRP) complex that consists of a 7SL RNA molecule of 300 nucleotides and six protein subunits: SRP72, SRP68, SRP54, SRP19, SRP14 and SRP9.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). Binds to the signal sequence of presecretory proteins when they emerge from the ribosomes.|||Cytoplasm|||Has a two domain structure: the G-domain binds GTP; the M-domain binds the 7S RNA in presence of SRP19 and also binds the signal sequence.|||Nucleus speckle|||Signal recognition particle consists of a 7S RNA molecule and at least six protein subunits. http://togogenome.org/gene/59894:SPECC1L ^@ http://purl.uniprot.org/uniprot/U3JY10 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytospin-A family.|||Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration.|||May interact with both microtubules and actin cytoskeleton.|||cytoskeleton|||gap junction|||spindle http://togogenome.org/gene/59894:CPEB3 ^@ http://purl.uniprot.org/uniprot/A0A803VAL9|||http://purl.uniprot.org/uniprot/A0A803W7X8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/59894:ATP5H ^@ http://purl.uniprot.org/uniprot/U3JET3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase d subunit family.|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain and the peripheric stalk, which acts as a stator to hold the catalytic alpha(3)beta(3) subcomplex and subunit a/ATP6 static relative to the rotary elements.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SLC37A4 ^@ http://purl.uniprot.org/uniprot/A0A803VBY6|||http://purl.uniprot.org/uniprot/A0A803VVI4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/59894:C1R ^@ http://purl.uniprot.org/uniprot/A0A803VZF6 ^@ Caution|||Function|||Subunit ^@ C1 is a calcium-dependent trimolecular complex of C1q, C1r and C1s in the molar ration of 1:2:2. C1r is a dimer of identical chains, each of which is activated by cleavage into two chains, A and B, connected by disulfide bonds.|||C1r B chain is a serine protease that combines with C1q and C1s to form C1, the first component of the classical pathway of the complement system.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:DPH5 ^@ http://purl.uniprot.org/uniprot/U3JIG1 ^@ Function|||Similarity ^@ Belongs to the diphthine synthase family.|||S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis. http://togogenome.org/gene/59894:HIBADH ^@ http://purl.uniprot.org/uniprot/U3K421 ^@ Similarity ^@ Belongs to the HIBADH-related family. 3-hydroxyisobutyrate dehydrogenase subfamily. http://togogenome.org/gene/59894:LOC101812865 ^@ http://purl.uniprot.org/uniprot/A0A803VEH8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 31 family. http://togogenome.org/gene/59894:PPP2R2C ^@ http://purl.uniprot.org/uniprot/A0A803V4G1|||http://purl.uniprot.org/uniprot/A0A803VVL7|||http://purl.uniprot.org/uniprot/U3K4T1 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/59894:ALG3 ^@ http://purl.uniprot.org/uniprot/U3K006 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first Dol-P-Man derived mannose in an alpha-1,3 linkage to Man(5)GlcNAc(2)-PP-Dol.|||Belongs to the glycosyltransferase 58 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MBTD1 ^@ http://purl.uniprot.org/uniprot/U3JFB2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101821531 ^@ http://purl.uniprot.org/uniprot/U3JYX5 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:RAB29 ^@ http://purl.uniprot.org/uniprot/U3JCW9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane http://togogenome.org/gene/59894:C28H19orf24 ^@ http://purl.uniprot.org/uniprot/U3KHW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM174 family.|||Membrane http://togogenome.org/gene/59894:MAPK6 ^@ http://purl.uniprot.org/uniprot/U3KBI0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/59894:TSTA3 ^@ http://purl.uniprot.org/uniprot/A0A803VKN1 ^@ Function|||Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. Fucose synthase subfamily.|||Catalyzes the two-step NADP-dependent conversion of GDP-4-dehydro-6-deoxy-D-mannose to GDP-fucose, involving an epimerase and a reductase reaction. http://togogenome.org/gene/59894:C26H6orf89 ^@ http://purl.uniprot.org/uniprot/U3JKW6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:NXPH2 ^@ http://purl.uniprot.org/uniprot/U3KI60 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/59894:SNX10 ^@ http://purl.uniprot.org/uniprot/A0A803VSX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/59894:ZDHHC6 ^@ http://purl.uniprot.org/uniprot/U3JHU8 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:LOC101822184 ^@ http://purl.uniprot.org/uniprot/A0A803VKW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Membrane http://togogenome.org/gene/59894:FSHB ^@ http://purl.uniprot.org/uniprot/A0A803W6Y6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycoprotein hormones subunit beta family.|||Secreted http://togogenome.org/gene/59894:SLC25A19 ^@ http://purl.uniprot.org/uniprot/A0A803V5N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:TRIAP1 ^@ http://purl.uniprot.org/uniprot/U3JYN8 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/59894:LYVE1 ^@ http://purl.uniprot.org/uniprot/U3JE45 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101816363 ^@ http://purl.uniprot.org/uniprot/U3K5X1 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/59894:CERS4 ^@ http://purl.uniprot.org/uniprot/U3KBM2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/59894:GRIN2B ^@ http://purl.uniprot.org/uniprot/U3KAB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/59894:MICAL1 ^@ http://purl.uniprot.org/uniprot/U3JM18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/59894:USP48 ^@ http://purl.uniprot.org/uniprot/U3JM78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family.|||Nucleus http://togogenome.org/gene/59894:MYH11 ^@ http://purl.uniprot.org/uniprot/A0A803VQH0|||http://purl.uniprot.org/uniprot/U3KI15|||http://purl.uniprot.org/uniprot/U3KI16 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:DDOST ^@ http://purl.uniprot.org/uniprot/U3JLW6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the DDOST 48 kDa subunit family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). http://togogenome.org/gene/59894:DUSP6 ^@ http://purl.uniprot.org/uniprot/A0A803VPX5|||http://purl.uniprot.org/uniprot/U3K7T7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/59894:ACAN ^@ http://purl.uniprot.org/uniprot/U3K7A3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:GGT5 ^@ http://purl.uniprot.org/uniprot/U3JXW1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/59894:BOK ^@ http://purl.uniprot.org/uniprot/U3JLA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Membrane http://togogenome.org/gene/59894:LOC101820568 ^@ http://purl.uniprot.org/uniprot/A0A803V313 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:ZDHHC16 ^@ http://purl.uniprot.org/uniprot/U3K198 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Endoplasmic reticulum membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:CPSF4 ^@ http://purl.uniprot.org/uniprot/A0A803V2Y4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CPSF4/YTH1 family.|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex that play a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. CPSF4 binds RNA polymers with a preference for poly(U).|||Component of the cleavage and polyadenylation specificity factor (CPSF) complex.|||Nucleus http://togogenome.org/gene/59894:SLC13A2 ^@ http://purl.uniprot.org/uniprot/U3JVD9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59894:TSR1 ^@ http://purl.uniprot.org/uniprot/U3JVK7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:UBE4B ^@ http://purl.uniprot.org/uniprot/U3JXQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/59894:TNFAIP2 ^@ http://purl.uniprot.org/uniprot/U3JJG5 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/59894:C15H12orf49 ^@ http://purl.uniprot.org/uniprot/A0A803VAP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPRING family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:BMPR1B ^@ http://purl.uniprot.org/uniprot/U3JUC2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101812891 ^@ http://purl.uniprot.org/uniprot/U3JK74 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:THBS1 ^@ http://purl.uniprot.org/uniprot/U3JS61 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:PDK1 ^@ http://purl.uniprot.org/uniprot/A0A803WAK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/59894:EOMES ^@ http://purl.uniprot.org/uniprot/U3K3H0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:ILKAP ^@ http://purl.uniprot.org/uniprot/U3JLJ1 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59894:MAB21L1 ^@ http://purl.uniprot.org/uniprot/A0A803W1X8 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/59894:FAM3B ^@ http://purl.uniprot.org/uniprot/U3JHE2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/59894:LOC101815274 ^@ http://purl.uniprot.org/uniprot/U3KF66 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:ASCC1 ^@ http://purl.uniprot.org/uniprot/U3KDX1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ACOX3 ^@ http://purl.uniprot.org/uniprot/U3K4Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/59894:FLOT2 ^@ http://purl.uniprot.org/uniprot/U3JV22 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the band 7/mec-2 family. Flotillin subfamily.|||Endosome|||Heterooligomeric complex.|||Membrane http://togogenome.org/gene/59894:DERL1 ^@ http://purl.uniprot.org/uniprot/U3JID9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/59894:SS18L1 ^@ http://purl.uniprot.org/uniprot/U3K7Q4 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/59894:DNASE2B ^@ http://purl.uniprot.org/uniprot/A0A803VMP2 ^@ Similarity ^@ Belongs to the DNase II family. http://togogenome.org/gene/59894:LOC101809793 ^@ http://purl.uniprot.org/uniprot/U3JIK0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:MED1 ^@ http://purl.uniprot.org/uniprot/U3JCS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 1 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/59894:NOS2 ^@ http://purl.uniprot.org/uniprot/U3JQR4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the NOS family.|||Binds 1 FAD.|||Binds 1 FMN.|||Produces nitric oxide (NO) which is a messenger molecule with diverse functions throughout the body. http://togogenome.org/gene/59894:EIF3I ^@ http://purl.uniprot.org/uniprot/A0A803VD57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit I family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/59894:GTF2H3 ^@ http://purl.uniprot.org/uniprot/U3K3V8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB4 family.|||Component of the general transcription and DNA repair factor IIH (TFIIH) core complex, which is involved in general and transcription-coupled nucleotide excision repair (NER) of damaged DNA and, when complexed to CAK, in RNA transcription by RNA polymerase II. In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape. Phosphorylation of the C-terminal tail (CTD) of the largest subunit of RNA polymerase II by the kinase module CAK controls the initiation of transcription.|||Nucleus|||Part of a TFIID-containing RNA polymerase II pre-initiation complex that is composed of TBP and at least GTF2A1, GTF2A2, GTF2E1, GTF2E2, GTF2F1, GTF2H2, GTF2H3, GTF2H4, GTF2H5, GTF2B, TCEA1, ERCC2, ERCC3, TAF1, TAF2, TAF3, TAF4, TAF5, TAF6, TAF7, TAF8, TAF9, TAF10, TAF11, TAF12 and TAF13. Component of the 7-subunit TFIIH core complex composed of XPB/ERCC3, XPD/ERCC2, GTF2H1, GTF2H2, GTF2H3, GTF2H4 and GTF2H5, which is active in NER. The core complex associates with the 3-subunit CDK-activating kinase (CAK) module composed of CCNH/cyclin H, CDK7 and MNAT1 to form the 10-subunit holoenzyme (holo-TFIIH) active in transcription. Interacts with RARA; the interaction requires prior phosphorylation of RARA on 'Ser-369' which then enhances interaction of RARA with CDK7. http://togogenome.org/gene/59894:CDCA7 ^@ http://purl.uniprot.org/uniprot/U3JJT6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:STOML2 ^@ http://purl.uniprot.org/uniprot/U3K564 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/59894:FTCD ^@ http://purl.uniprot.org/uniprot/U3JN26 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Binds and promotes bundling of vimentin filaments originating from the Golgi.|||Folate-dependent enzyme, that displays both transferase and deaminase activity. Serves to channel one-carbon units from formiminoglutamate to the folate pool.|||Golgi apparatus|||Homooctamer, including four polyglutamate binding sites. The subunits are arranged as a tetramer of dimers, and form a planar ring-shaped structure.|||In the C-terminal section; belongs to the cyclodeaminase/cyclohydrolase family.|||In the N-terminal section; belongs to the formiminotransferase family.|||centriole http://togogenome.org/gene/59894:KCNJ8 ^@ http://purl.uniprot.org/uniprot/A0A803VQ12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59894:PLXNB2 ^@ http://purl.uniprot.org/uniprot/U3K5C4 ^@ Caution|||Similarity ^@ Belongs to the plexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GPR182 ^@ http://purl.uniprot.org/uniprot/U3KIG7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:LOC101818819 ^@ http://purl.uniprot.org/uniprot/U3JE70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:LAMA4 ^@ http://purl.uniprot.org/uniprot/A0A803VQI6|||http://purl.uniprot.org/uniprot/U3K8U2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:USO1 ^@ http://purl.uniprot.org/uniprot/A0A803VSK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VDP/USO1/EDE1 family.|||Membrane http://togogenome.org/gene/59894:SLC6A14 ^@ http://purl.uniprot.org/uniprot/U3JGH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:CIAPIN1 ^@ http://purl.uniprot.org/uniprot/A0A803W9F5|||http://purl.uniprot.org/uniprot/U3JWV0 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the anamorsin family.|||Component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery required for the maturation of extramitochondrial Fe-S proteins. Part of an electron transfer chain functioning in an early step of cytosolic Fe-S biogenesis, facilitating the de novo assembly of a [4Fe-4S] cluster on the scaffold complex NUBP1-NUBP2. Electrons are transferred to CIAPIN1 from NADPH via the FAD- and FMN-containing protein NDOR1. NDOR1-CIAPIN1 are also required for the assembly of the diferric tyrosyl radical cofactor of ribonucleotide reductase (RNR), probably by providing electrons for reduction during radical cofactor maturation in the catalytic small subunit. Has anti-apoptotic effects in the cell. Involved in negative control of cell death upon cytokine withdrawal. Promotes development of hematopoietic cells.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrion intermembrane space|||Monomer. Interacts with NDOR1. Interacts with CHCHD4.|||Nucleus|||The C-terminal domain binds 2 Fe-S clusters but is otherwise mostly in an intrinsically disordered conformation.|||The N-terminal domain has structural similarity with S-adenosyl-L-methionine-dependent methyltransferases, but does not bind S-adenosyl-L-methionine. It is required for correct assembly of the 2 Fe-S clusters.|||The twin Cx2C motifs are involved in the recognition by the mitochondrial CHCHD4/MIA40-GFER/ERV1 disulfide relay system. The formation of 2 disulfide bonds in the Cx2C motifs through dithiol/disulfide exchange reactions effectively traps the protein in the mitochondrial intermembrane space. http://togogenome.org/gene/59894:CACNB3 ^@ http://purl.uniprot.org/uniprot/U3JBH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||Cytoplasm http://togogenome.org/gene/59894:MAPKAPK3 ^@ http://purl.uniprot.org/uniprot/A0A803VNS9|||http://purl.uniprot.org/uniprot/U3K2Q0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:GLIS3 ^@ http://purl.uniprot.org/uniprot/U3K7G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/59894:NR1H4 ^@ http://purl.uniprot.org/uniprot/U3K961 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/59894:CRYBB2 ^@ http://purl.uniprot.org/uniprot/A0A803V1Y3|||http://purl.uniprot.org/uniprot/U3K1U9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/59894:CCNF ^@ http://purl.uniprot.org/uniprot/A0A803VJD3|||http://purl.uniprot.org/uniprot/U3JQC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family.|||centriole|||perinuclear region http://togogenome.org/gene/59894:LIPT1 ^@ http://purl.uniprot.org/uniprot/U3JMV3 ^@ Similarity ^@ Belongs to the LplA family. http://togogenome.org/gene/59894:FAM234A ^@ http://purl.uniprot.org/uniprot/A0A803VNW7 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/59894:GAPVD1 ^@ http://purl.uniprot.org/uniprot/A0A803VX14|||http://purl.uniprot.org/uniprot/U3JHL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GAPVD1 family.|||Membrane http://togogenome.org/gene/59894:MEGF11 ^@ http://purl.uniprot.org/uniprot/U3K625 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:RAB9B ^@ http://purl.uniprot.org/uniprot/U3KL64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/59894:SLC6A8 ^@ http://purl.uniprot.org/uniprot/U3KF24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:DTNBP1 ^@ http://purl.uniprot.org/uniprot/U3KG51 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/59894:EXOC1 ^@ http://purl.uniprot.org/uniprot/A0A803V8R6|||http://purl.uniprot.org/uniprot/A0A803W1M2|||http://purl.uniprot.org/uniprot/A0A803W9V8|||http://purl.uniprot.org/uniprot/U3JM13 ^@ Similarity ^@ Belongs to the SEC3 family. http://togogenome.org/gene/59894:PNRC1 ^@ http://purl.uniprot.org/uniprot/U3JJY5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ACTC1 ^@ http://purl.uniprot.org/uniprot/U3JT25 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:LOC101807990 ^@ http://purl.uniprot.org/uniprot/A0A803V439 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:XRCC4 ^@ http://purl.uniprot.org/uniprot/A0A803WCY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XRCC4-XLF family. XRCC4 subfamily.|||Nucleus http://togogenome.org/gene/59894:NASP ^@ http://purl.uniprot.org/uniprot/U3K4N5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NASP family.|||Nucleus http://togogenome.org/gene/59894:GRB10 ^@ http://purl.uniprot.org/uniprot/A0A803W7A0|||http://purl.uniprot.org/uniprot/U3JYK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/59894:LOC101816499 ^@ http://purl.uniprot.org/uniprot/U3KJZ1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor specific to the heptapeptide core common to adrenocorticotropic hormone and alpha-, beta-, and gamma-MSH. Plays a central role in energy homeostasis and somatic growth. This receptor is mediated by G proteins that stimulate adenylate cyclase (cAMP). http://togogenome.org/gene/59894:CCND1 ^@ http://purl.uniprot.org/uniprot/U3JFA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:XRCC6 ^@ http://purl.uniprot.org/uniprot/U3KBP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ku70 family.|||Nucleus http://togogenome.org/gene/59894:PSMA3 ^@ http://purl.uniprot.org/uniprot/U3JLS7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59894:PDYN ^@ http://purl.uniprot.org/uniprot/A0A803V5L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Dynorphin peptides differentially regulate the kappa opioid receptor. Dynorphin A(1-13) has a typical opiod activity, it is 700 times more potent than Leu-enkephalin.|||Leu-enkephalins compete with and mimic the effects of opiate drugs. They play a role in a number of physiologic functions, including pain perception and responses to stress.|||Leumorphin has a typical opiod activity and may have anti-apoptotic effect.|||Secreted http://togogenome.org/gene/59894:GFM1 ^@ http://purl.uniprot.org/uniprot/U3JYU4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. EF-G/EF-2 subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mitochondrial GTPase that catalyzes the GTP-dependent ribosomal translocation step during translation elongation. During this step, the ribosome changes from the pre-translocational (PRE) to the post-translocational (POST) state as the newly formed A-site-bound peptidyl-tRNA and P-site-bound deacylated tRNA move to the P and E sites, respectively. Catalyzes the coordinated movement of the two tRNA molecules, the mRNA and conformational changes in the ribosome. Does not mediate the disassembly of ribosomes from messenger RNA at the termination of mitochondrial protein biosynthesis.|||Mitochondrion http://togogenome.org/gene/59894:SLC25A36 ^@ http://purl.uniprot.org/uniprot/U3JW16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:UNC93A ^@ http://purl.uniprot.org/uniprot/U3KCY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/59894:PDE7A ^@ http://purl.uniprot.org/uniprot/A0A803WBN4|||http://purl.uniprot.org/uniprot/U3JSD0 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:DDO ^@ http://purl.uniprot.org/uniprot/A0A803VZ82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAMOX/DASOX family.|||Peroxisome http://togogenome.org/gene/59894:LOC101820005 ^@ http://purl.uniprot.org/uniprot/U3K4I2 ^@ Function ^@ Mediates the production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3). Plays an important role in the regulation of intracellular signaling cascades. http://togogenome.org/gene/59894:CCNG1 ^@ http://purl.uniprot.org/uniprot/U3KGI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin G subfamily.|||May play a role in growth regulation. Is associated with G2/M phase arrest in response to DNA damage. May be an intermediate by which p53 mediates its role as an inhibitor of cellular proliferation.|||Nucleus http://togogenome.org/gene/59894:VCAN ^@ http://purl.uniprot.org/uniprot/U3KEK5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:VWA1 ^@ http://purl.uniprot.org/uniprot/U3K3Y9 ^@ Subcellular Location Annotation ^@ Membrane|||basement membrane http://togogenome.org/gene/59894:LOC101819049 ^@ http://purl.uniprot.org/uniprot/A0A803VRQ9|||http://purl.uniprot.org/uniprot/U3JJM7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101818299 ^@ http://purl.uniprot.org/uniprot/U3KIN8 ^@ Similarity ^@ Belongs to the pancreatic ribonuclease family. http://togogenome.org/gene/59894:BTAF1 ^@ http://purl.uniprot.org/uniprot/U3JZU4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CALCR ^@ http://purl.uniprot.org/uniprot/A0A803VAM7|||http://purl.uniprot.org/uniprot/U3K726 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Interacts with GPRASP2.|||Membrane http://togogenome.org/gene/59894:LOC101811991 ^@ http://purl.uniprot.org/uniprot/U3KL17 ^@ Subcellular Location Annotation|||Subunit ^@ Cell membrane|||Interacts with NCDN.|||Membrane http://togogenome.org/gene/59894:ACTN1 ^@ http://purl.uniprot.org/uniprot/A0A803V8Q4|||http://purl.uniprot.org/uniprot/A0A803VS66|||http://purl.uniprot.org/uniprot/U3JR83 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/59894:PDCL ^@ http://purl.uniprot.org/uniprot/U3JH34 ^@ Similarity ^@ Belongs to the phosducin family. http://togogenome.org/gene/59894:RGS12 ^@ http://purl.uniprot.org/uniprot/U3K540 ^@ Subcellular Location Annotation ^@ Cytoplasm|||dendrite http://togogenome.org/gene/59894:LOC101822182 ^@ http://purl.uniprot.org/uniprot/U3JBQ4 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/59894:SLITRK2 ^@ http://purl.uniprot.org/uniprot/U3KLC8 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/59894:WISP2 ^@ http://purl.uniprot.org/uniprot/A0A803WDW5 ^@ Similarity ^@ Belongs to the CCN family. http://togogenome.org/gene/59894:TXLNA ^@ http://purl.uniprot.org/uniprot/U3JCX8 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/59894:LEFTY1 ^@ http://purl.uniprot.org/uniprot/U3KAX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Secreted http://togogenome.org/gene/59894:RAD18 ^@ http://purl.uniprot.org/uniprot/U3KGR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAD18 family.|||Nucleus http://togogenome.org/gene/59894:SDC4 ^@ http://purl.uniprot.org/uniprot/U3JSB6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane http://togogenome.org/gene/59894:CCDC90B ^@ http://purl.uniprot.org/uniprot/U3JZ69 ^@ Similarity ^@ Belongs to the CCDC90 family. http://togogenome.org/gene/59894:CAPN10 ^@ http://purl.uniprot.org/uniprot/U3JZH2 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59894:NUP107 ^@ http://purl.uniprot.org/uniprot/U3K6A8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nucleoporin Nup84/Nup107 family.|||Functions as a component of the nuclear pore complex (NPC).|||Nucleus membrane|||Part of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/59894:SLC25A22 ^@ http://purl.uniprot.org/uniprot/U3K7B5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:HSPB8 ^@ http://purl.uniprot.org/uniprot/U3JZ23 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Cytoplasm|||Displays temperature-dependent chaperone activity. http://togogenome.org/gene/59894:TSPAN3 ^@ http://purl.uniprot.org/uniprot/A0A803WF08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:LOC101809150 ^@ http://purl.uniprot.org/uniprot/A0A803W6D5|||http://purl.uniprot.org/uniprot/U3JD84 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:PIGZ ^@ http://purl.uniprot.org/uniprot/U3JXB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:PTGR1 ^@ http://purl.uniprot.org/uniprot/U3JBP1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer or homodimer. http://togogenome.org/gene/59894:IMPA1 ^@ http://purl.uniprot.org/uniprot/U3K1U8 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/59894:LOC101819664 ^@ http://purl.uniprot.org/uniprot/U3KF10 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:APOO ^@ http://purl.uniprot.org/uniprot/A0A803WC72 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the apolipoprotein O/MICOS complex subunit Mic27 family.|||Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane.|||Component of the mitochondrial contact site and cristae organizing system (MICOS) complex.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:PPM1K ^@ http://purl.uniprot.org/uniprot/U3JS49 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59894:CPPED1 ^@ http://purl.uniprot.org/uniprot/A0A803V3U2|||http://purl.uniprot.org/uniprot/U3JMQ4 ^@ Similarity ^@ Belongs to the metallophosphoesterase superfamily. CPPED1 family. http://togogenome.org/gene/59894:ST3GAL3 ^@ http://purl.uniprot.org/uniprot/A0A803V6K6|||http://purl.uniprot.org/uniprot/A0A803VJW0|||http://purl.uniprot.org/uniprot/A0A803VSR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:CD151 ^@ http://purl.uniprot.org/uniprot/U3K7D2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:STT3A ^@ http://purl.uniprot.org/uniprot/U3JRA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/59894:PEMT ^@ http://purl.uniprot.org/uniprot/U3KH69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class VI-like SAM-binding methyltransferase superfamily. PEMT/PEM2 methyltransferase family.|||Catalyzes the three sequential steps of the methylation pathway for the biosynthesis of phosphatidylcholine, a critical and essential component for membrane structure. Uses S-adenosylmethionine (S-adenosyl-L-methionine, SAM or AdoMet) as the methyl group donor for the methylation of phosphatidylethanolamine (1,2-diacyl-sn-glycero-3-phosphoethanolamine, PE) to phosphatidylmonomethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N-methylethanolamine, PMME), PMME to phosphatidyldimethylethanolamine (1,2-diacyl-sn-glycero-3-phospho-N,N-dimethylethanolamine, PDME), and PDME to phosphatidylcholine (1,2-diacyl-sn-glycero-3-phosphocholine, PC), producing S-adenosyl-L-homocysteine in each step.|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:ADRB1 ^@ http://purl.uniprot.org/uniprot/U3JHS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:DMD ^@ http://purl.uniprot.org/uniprot/A0A803V1B5 ^@ Function|||Subcellular Location Annotation ^@ May play a role in anchoring the cytoskeleton to the plasma membrane.|||cytoskeleton http://togogenome.org/gene/59894:TUSC5 ^@ http://purl.uniprot.org/uniprot/U3JUE9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:E2F7 ^@ http://purl.uniprot.org/uniprot/U3K779 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/59894:SPRY2 ^@ http://purl.uniprot.org/uniprot/U3KJZ4 ^@ Similarity ^@ Belongs to the sprouty family. http://togogenome.org/gene/59894:VTI1A ^@ http://purl.uniprot.org/uniprot/A0A803VI63|||http://purl.uniprot.org/uniprot/A0A803WCT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VTI1 family.|||Membrane http://togogenome.org/gene/59894:BRCA1 ^@ http://purl.uniprot.org/uniprot/U3JDH4 ^@ Subcellular Location Annotation ^@ Chromosome|||Cytoplasm http://togogenome.org/gene/59894:ASPH ^@ http://purl.uniprot.org/uniprot/A0A803VQG2|||http://purl.uniprot.org/uniprot/A0A803VQQ8|||http://purl.uniprot.org/uniprot/A0A803WH43|||http://purl.uniprot.org/uniprot/U3JSM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family.|||Membrane http://togogenome.org/gene/59894:PDP2 ^@ http://purl.uniprot.org/uniprot/U3KIV8 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59894:FGF10 ^@ http://purl.uniprot.org/uniprot/U3K9I8 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59894:TSPO ^@ http://purl.uniprot.org/uniprot/A0A803VR99 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/59894:TMCO3 ^@ http://purl.uniprot.org/uniprot/U3JKZ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ARL2BP ^@ http://purl.uniprot.org/uniprot/U3JX12 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL2BP family.|||Cytoplasm|||Mitochondrion intermembrane space|||Nucleus|||Plays a role as an effector of the ADP-ribosylation factor-like protein 2, ARL2.|||centrosome|||cilium basal body http://togogenome.org/gene/59894:NCOA7 ^@ http://purl.uniprot.org/uniprot/A0A803VHK5|||http://purl.uniprot.org/uniprot/U3KAB5 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/59894:FIGN ^@ http://purl.uniprot.org/uniprot/U3KKF0 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59894:PTDSS1 ^@ http://purl.uniprot.org/uniprot/U3JSX9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phosphatidyl serine synthase family.|||Catalyzes a base-exchange reaction in which the polar head group of phosphatidylethanolamine (PE) is replaced by L-serine.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:HNRNPA3 ^@ http://purl.uniprot.org/uniprot/A0A803WG68|||http://purl.uniprot.org/uniprot/U3JKP4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:FZD10 ^@ http://purl.uniprot.org/uniprot/U3KJS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:KMO ^@ http://purl.uniprot.org/uniprot/U3KFV1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aromatic-ring hydroxylase family. KMO subfamily.|||Catalyzes the hydroxylation of L-kynurenine (L-Kyn) to form 3-hydroxy-L-kynurenine (L-3OHKyn). Required for synthesis of quinolinic acid.|||Mitochondrion outer membrane http://togogenome.org/gene/59894:KAT7 ^@ http://purl.uniprot.org/uniprot/A0A803V6P7|||http://purl.uniprot.org/uniprot/U3JRM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/59894:ALDH7A1 ^@ http://purl.uniprot.org/uniprot/U3JIT7 ^@ Similarity|||Subunit ^@ Belongs to the aldehyde dehydrogenase family.|||Homotetramer. http://togogenome.org/gene/59894:ARHGDIA ^@ http://purl.uniprot.org/uniprot/A0A803V688 ^@ Similarity ^@ Belongs to the Rho GDI family. http://togogenome.org/gene/59894:TAF12 ^@ http://purl.uniprot.org/uniprot/U3JF79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF12 family.|||Nucleus http://togogenome.org/gene/59894:TLR3 ^@ http://purl.uniprot.org/uniprot/U3KBQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59894:CTSA ^@ http://purl.uniprot.org/uniprot/U3JPR2 ^@ Similarity ^@ Belongs to the peptidase S10 family. http://togogenome.org/gene/59894:ARGLU1 ^@ http://purl.uniprot.org/uniprot/A0A803WDG0 ^@ Similarity ^@ Belongs to the UPF0430 family. http://togogenome.org/gene/59894:RNF168 ^@ http://purl.uniprot.org/uniprot/A0A803WD69 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNF168 family.|||E3 ubiquitin-protein ligase required for accumulation of repair proteins to sites of DNA damage. Acts with UBE2N/UBC13 to amplify the RNF8-dependent histone ubiquitination. Recruited to sites of DNA damage at double-strand breaks (DSBs) by binding to ubiquitinated histone H2A and ubiquitinates histone H2A and H2AX, leading to amplify the RNF8-dependent H2A ubiquitination and promoting the formation of 'Lys-63'-linked ubiquitin conjugates. This leads to concentrate ubiquitinated histones H2A and H2AX at DNA lesions to the threshold required for recruitment of TP53BP1 and BRCA1. Catalyzes monoubiquitination of 'Lys-13' and 'Lys-15' of nucleosomal histone H2A (H2AK13Ub and H2AK15Ub, respectively).|||Monomer.|||Nucleus|||The MIU motif (motif interacting with ubiquitin) mediates the interaction with both 'Lys-48'- and 'Lys-63'-linked ubiquitin chains. The UMI motif mediates interaction with ubiquitin with a preference for 'Lys-63'-linked ubiquitin. The specificity for different types of ubiquitin is mediated by juxtaposition of ubiquitin-binding motifs (MIU and UMI motifs) with LR motifs (LRMs). http://togogenome.org/gene/59894:CAPN6 ^@ http://purl.uniprot.org/uniprot/U3K956 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59894:MCM4 ^@ http://purl.uniprot.org/uniprot/U3JTB4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/59894:PRPF18 ^@ http://purl.uniprot.org/uniprot/A0A803VAF6|||http://purl.uniprot.org/uniprot/U3JGT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRP18 family.|||Nucleus speckle http://togogenome.org/gene/59894:CACNG3 ^@ http://purl.uniprot.org/uniprot/A0A803W6Q6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:CCT8 ^@ http://purl.uniprot.org/uniprot/A0A803W3B9|||http://purl.uniprot.org/uniprot/U3JUZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||cilium basal body http://togogenome.org/gene/59894:VAX1 ^@ http://purl.uniprot.org/uniprot/A0A803V9Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMX homeobox family.|||Nucleus http://togogenome.org/gene/59894:LOC101815176 ^@ http://purl.uniprot.org/uniprot/U3JXV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/59894:FANCC ^@ http://purl.uniprot.org/uniprot/U3JLK4 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Belongs to the multisubunit FA complex composed of FANCA, FANCB, FANCC, FANCE, FANCF, FANCG, FANCL/PHF9 and FANCM. This complex may also include HSP70.|||DNA repair protein that may operate in a postreplication repair or a cell cycle checkpoint function. May be implicated in interstrand DNA cross-link repair and in the maintenance of normal chromosome stability. Upon IFNG induction, may facilitate STAT1 activation by recruiting STAT1 to IFNGR1.|||Nucleus http://togogenome.org/gene/59894:TMEM8B ^@ http://purl.uniprot.org/uniprot/U3JBK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:FGF18 ^@ http://purl.uniprot.org/uniprot/U3JKZ2 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59894:FAT2 ^@ http://purl.uniprot.org/uniprot/U3K0L5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ALCAM ^@ http://purl.uniprot.org/uniprot/U3JVN1 ^@ Subcellular Location Annotation ^@ Cell membrane|||axon|||dendrite http://togogenome.org/gene/59894:PIAS4 ^@ http://purl.uniprot.org/uniprot/U3JDP5 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/59894:SLC27A4 ^@ http://purl.uniprot.org/uniprot/U3JF62 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:POPDC2 ^@ http://purl.uniprot.org/uniprot/A0A803UZV9|||http://purl.uniprot.org/uniprot/A0A803V1T3 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/59894:SCG5 ^@ http://purl.uniprot.org/uniprot/A0A803V4L5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 7B2 family.|||Secreted http://togogenome.org/gene/59894:NCOR2 ^@ http://purl.uniprot.org/uniprot/U3K414 ^@ Similarity ^@ Belongs to the N-CoR nuclear receptor corepressors family. http://togogenome.org/gene/59894:SCFD1 ^@ http://purl.uniprot.org/uniprot/U3JTE9 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/59894:RNF34 ^@ http://purl.uniprot.org/uniprot/U3K3E3 ^@ Subcellular Location Annotation ^@ Cell membrane http://togogenome.org/gene/59894:KCNS1 ^@ http://purl.uniprot.org/uniprot/U3JS80 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PSMG2 ^@ http://purl.uniprot.org/uniprot/U3JVE0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the PSMG2 family.|||Chaperone protein which promotes assembly of the 20S proteasome as part of a heterodimer with PSMG1.|||Forms a heterodimer with PSMG1. http://togogenome.org/gene/59894:HMGCS1 ^@ http://purl.uniprot.org/uniprot/A0A803WCL3|||http://purl.uniprot.org/uniprot/U3K9C6 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/59894:METTL11B ^@ http://purl.uniprot.org/uniprot/U3JZL2 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/59894:SLC16A7 ^@ http://purl.uniprot.org/uniprot/U3JY00 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:MAPK8IP3 ^@ http://purl.uniprot.org/uniprot/A0A803VRH5 ^@ Similarity ^@ Belongs to the JIP scaffold family. http://togogenome.org/gene/59894:ACTR10 ^@ http://purl.uniprot.org/uniprot/U3JLU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin family.|||cytoskeleton http://togogenome.org/gene/59894:SLITRK4 ^@ http://purl.uniprot.org/uniprot/U3KLB5 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/59894:EFTUD2 ^@ http://purl.uniprot.org/uniprot/U3JYM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily.|||Nucleus http://togogenome.org/gene/59894:GREM2 ^@ http://purl.uniprot.org/uniprot/U3KKZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/59894:LOC101809294 ^@ http://purl.uniprot.org/uniprot/U3JU73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:GPR1 ^@ http://purl.uniprot.org/uniprot/U3KLJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Belongs to the chemokine-like receptor (CMKLR) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:UBAC2 ^@ http://purl.uniprot.org/uniprot/A0A803VA41 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:EP400 ^@ http://purl.uniprot.org/uniprot/U3K0Q6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TGFB3 ^@ http://purl.uniprot.org/uniprot/U3JV88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Transforming growth factor beta-3 proprotein: Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-3 (TGF-beta-3) chains, which constitute the regulatory and active subunit of TGF-beta-3, respectively.|||extracellular matrix http://togogenome.org/gene/59894:RFX3 ^@ http://purl.uniprot.org/uniprot/A0A803WAH2|||http://purl.uniprot.org/uniprot/U3K7G4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DNMT3B ^@ http://purl.uniprot.org/uniprot/A0A803VCF9|||http://purl.uniprot.org/uniprot/A0A803VMF5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PIGF ^@ http://purl.uniprot.org/uniprot/U3KEJ3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MRPL46 ^@ http://purl.uniprot.org/uniprot/U3K777 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL46 family.|||Mitochondrion http://togogenome.org/gene/59894:SARS ^@ http://purl.uniprot.org/uniprot/U3JI42 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type-1 seryl-tRNA synthetase subfamily. http://togogenome.org/gene/59894:HAAO ^@ http://purl.uniprot.org/uniprot/U3KDT3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 3-HAO family.|||Catalyzes the oxidative ring opening of 3-hydroxyanthranilate to 2-amino-3-carboxymuconate semialdehyde, which spontaneously cyclizes to quinolinate.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer. http://togogenome.org/gene/59894:OTX1 ^@ http://purl.uniprot.org/uniprot/U3KGN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:RRN3 ^@ http://purl.uniprot.org/uniprot/U3JMM1 ^@ Similarity ^@ Belongs to the RRN3 family. http://togogenome.org/gene/59894:GDAP2 ^@ http://purl.uniprot.org/uniprot/U3JRA0 ^@ Similarity ^@ Belongs to the GDAP2 family. http://togogenome.org/gene/59894:TMEM39A ^@ http://purl.uniprot.org/uniprot/U3JU79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/59894:FAM168B ^@ http://purl.uniprot.org/uniprot/U3JLR4 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/59894:CACNG5 ^@ http://purl.uniprot.org/uniprot/U3JIA7 ^@ Similarity ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily. http://togogenome.org/gene/59894:MOGAT2 ^@ http://purl.uniprot.org/uniprot/U3KBP2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LRP12 ^@ http://purl.uniprot.org/uniprot/U3JU51 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:IRF8 ^@ http://purl.uniprot.org/uniprot/U3JVY3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:ALDH1A1 ^@ http://purl.uniprot.org/uniprot/U3KED1 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:PRKCD ^@ http://purl.uniprot.org/uniprot/U3JLH3 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Calcium-independent, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays contrasting roles in cell death and cell survival by functioning as a pro-apoptotic protein during DNA damage-induced apoptosis, but acting as an anti-apoptotic protein during cytokine receptor-initiated cell death, is involved in tumor suppression.|||Cytoplasm|||Interacts with PDPK1 (via N-terminal region), RAD9A, CDCP1, MUC1 and VASP.|||Novel PKCs (PRKCD, PRKCE, PRKCH and PRKCQ) are calcium-insensitive, but activated by diacylglycerol (DAG) and phosphatidylserine.|||Nucleus|||perinuclear region http://togogenome.org/gene/59894:SLC22A18 ^@ http://purl.uniprot.org/uniprot/U3KA87 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:NOVA1 ^@ http://purl.uniprot.org/uniprot/A0A803V078|||http://purl.uniprot.org/uniprot/A0A803VGW5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:RIN3 ^@ http://purl.uniprot.org/uniprot/U3JID2 ^@ Similarity ^@ Belongs to the RIN (Ras interaction/interference) family. http://togogenome.org/gene/59894:ITPRIP ^@ http://purl.uniprot.org/uniprot/U3KL88 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Cell membrane|||Enhances Ca(2+)-mediated inhibition of inositol 1,4,5-triphosphate receptor (ITPR) Ca(2+) release.|||Membrane|||Nucleus outer membrane http://togogenome.org/gene/59894:SLC39A9 ^@ http://purl.uniprot.org/uniprot/A0A803VME6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZIP transporter (TC 2.A.5) family.|||May act as a zinc-influx transporter.|||Membrane http://togogenome.org/gene/59894:DGKB ^@ http://purl.uniprot.org/uniprot/A0A803WGH6|||http://purl.uniprot.org/uniprot/U3K5V3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59894:CACNG2 ^@ http://purl.uniprot.org/uniprot/A0A803VED8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Membrane|||Regulates the trafficking and gating properties of AMPA-selective glutamate receptors (AMPARs). Promotes their targeting to the cell membrane and synapses and modulates their gating properties by slowing their rates of activation, deactivation and desensitization. Does not show subunit-specific AMPA receptor regulation and regulates all AMPAR subunits. Thought to stabilize the calcium channel in an inactivated (closed) state. http://togogenome.org/gene/59894:C7H2orf76 ^@ http://purl.uniprot.org/uniprot/A0A803WH07 ^@ Similarity ^@ Belongs to the UPF0538 family. http://togogenome.org/gene/59894:GALK2 ^@ http://purl.uniprot.org/uniprot/U3KAD6 ^@ Similarity ^@ Belongs to the GHMP kinase family. GalK subfamily. http://togogenome.org/gene/59894:TNFAIP1 ^@ http://purl.uniprot.org/uniprot/U3JQC7 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/59894:SPOCK1 ^@ http://purl.uniprot.org/uniprot/U3K085 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101806183 ^@ http://purl.uniprot.org/uniprot/A0A803VKW0 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/59894:AK8 ^@ http://purl.uniprot.org/uniprot/U3JFI3 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/59894:CD36 ^@ http://purl.uniprot.org/uniprot/U3K7F3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the CD36 family.|||Cell membrane|||Golgi apparatus|||Membrane|||Membrane raft http://togogenome.org/gene/59894:ZC3H12A ^@ http://purl.uniprot.org/uniprot/U3JDR7 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/59894:WDR35 ^@ http://purl.uniprot.org/uniprot/U3JGE7 ^@ Subcellular Location Annotation ^@ centrosome|||cilium basal body http://togogenome.org/gene/59894:UHRF1 ^@ http://purl.uniprot.org/uniprot/U3JEN0 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101821682 ^@ http://purl.uniprot.org/uniprot/A0A803VXK9|||http://purl.uniprot.org/uniprot/U3JU55 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ABCG2 ^@ http://purl.uniprot.org/uniprot/U3JRH5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Cell membrane|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:GRHL2 ^@ http://purl.uniprot.org/uniprot/A0A803VEH2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101807457 ^@ http://purl.uniprot.org/uniprot/U3K2C2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 2-5A synthase family.|||Cytoplasm http://togogenome.org/gene/59894:STAMBPL1 ^@ http://purl.uniprot.org/uniprot/U3JYY2 ^@ Similarity ^@ Belongs to the peptidase M67C family. http://togogenome.org/gene/59894:SS18 ^@ http://purl.uniprot.org/uniprot/A0A803VZ89|||http://purl.uniprot.org/uniprot/U3JU68 ^@ Similarity ^@ Belongs to the SS18 family. http://togogenome.org/gene/59894:ISCU ^@ http://purl.uniprot.org/uniprot/A0A803VM54 ^@ Function|||Similarity ^@ Belongs to the NifU family.|||Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. http://togogenome.org/gene/59894:IP6K2 ^@ http://purl.uniprot.org/uniprot/U3K0U8 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/59894:HSP90B1 ^@ http://purl.uniprot.org/uniprot/U3JCU4 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/59894:MC5R ^@ http://purl.uniprot.org/uniprot/U3KIF8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for MSH (alpha, beta and gamma) and ACTH. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. This receptor is a possible mediator of the immunomodulation properties of melanocortins. http://togogenome.org/gene/59894:PIK3CD ^@ http://purl.uniprot.org/uniprot/U3JXY4 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/59894:GPR156 ^@ http://purl.uniprot.org/uniprot/U3JRZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TWF2 ^@ http://purl.uniprot.org/uniprot/A0A803W9I8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the actin-binding proteins ADF family. Twinfilin subfamily.|||cytoskeleton http://togogenome.org/gene/59894:CNPY2 ^@ http://purl.uniprot.org/uniprot/A0A803W9I4 ^@ Similarity ^@ Belongs to the canopy family. http://togogenome.org/gene/59894:CHRNA3 ^@ http://purl.uniprot.org/uniprot/U3K7X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:SCGN ^@ http://purl.uniprot.org/uniprot/U3JQ80 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:LRP8 ^@ http://purl.uniprot.org/uniprot/U3JTE0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:PRLR ^@ http://purl.uniprot.org/uniprot/U3JHD0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||Membrane|||The WSXWS motif appears to be necessary for proper protein folding and thereby efficient intracellular transport and cell-surface receptor binding.|||The box 1 motif is required for JAK interaction and/or activation.|||This is a receptor for the anterior pituitary hormone prolactin. http://togogenome.org/gene/59894:SEMA4G ^@ http://purl.uniprot.org/uniprot/U3K202 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101806737 ^@ http://purl.uniprot.org/uniprot/A0A803V0I8 ^@ Similarity ^@ Belongs to the cytochrome b5 family. http://togogenome.org/gene/59894:LDAH ^@ http://purl.uniprot.org/uniprot/A0A803VM01|||http://purl.uniprot.org/uniprot/U3JG83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. LDAH family.|||Lipid droplet http://togogenome.org/gene/59894:UGT8 ^@ http://purl.uniprot.org/uniprot/U3JE99 ^@ Similarity ^@ Belongs to the UDP-glycosyltransferase family. http://togogenome.org/gene/59894:TRAF3 ^@ http://purl.uniprot.org/uniprot/A0A803VUV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/59894:TUBB6 ^@ http://purl.uniprot.org/uniprot/U3JVB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:SMC4 ^@ http://purl.uniprot.org/uniprot/U3JF84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC4 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/59894:PCK1 ^@ http://purl.uniprot.org/uniprot/A0A803VVV7|||http://purl.uniprot.org/uniprot/U3K8A9 ^@ Similarity ^@ Belongs to the phosphoenolpyruvate carboxykinase [GTP] family. http://togogenome.org/gene/59894:RORA ^@ http://purl.uniprot.org/uniprot/U3KDN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:KIAA1147 ^@ http://purl.uniprot.org/uniprot/U3JME4 ^@ Similarity ^@ Belongs to the DENND11 family. http://togogenome.org/gene/59894:L3HYPDH ^@ http://purl.uniprot.org/uniprot/U3JLH4 ^@ Similarity ^@ Belongs to the proline racemase family. http://togogenome.org/gene/59894:WFIKKN2 ^@ http://purl.uniprot.org/uniprot/A0A803VPI2 ^@ Similarity ^@ Belongs to the WFIKKN family. http://togogenome.org/gene/59894:FIGF ^@ http://purl.uniprot.org/uniprot/U3JP78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Secreted http://togogenome.org/gene/59894:YWHAQ ^@ http://purl.uniprot.org/uniprot/A0A803VRU4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:EXOC3 ^@ http://purl.uniprot.org/uniprot/U3JQN6 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/59894:PFKFB2 ^@ http://purl.uniprot.org/uniprot/A0A803VP83|||http://purl.uniprot.org/uniprot/A0A803W5N8|||http://purl.uniprot.org/uniprot/U3JCR2 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/59894:PTHLH ^@ http://purl.uniprot.org/uniprot/U3JPV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parathyroid hormone family.|||Secreted http://togogenome.org/gene/59894:FAM126B ^@ http://purl.uniprot.org/uniprot/U3JNG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Belongs to the ORC2 family.|||Cell membrane|||Membrane|||Nucleus|||cytosol http://togogenome.org/gene/59894:LOC107603324 ^@ http://purl.uniprot.org/uniprot/U3JXL2 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:MID1 ^@ http://purl.uniprot.org/uniprot/U3JPI3 ^@ Function|||Subcellular Location Annotation ^@ Has E3 ubiquitin ligase activity towards IGBP1, promoting its monoubiquitination, which results in deprotection of the catalytic subunit of protein phosphatase PP2A, and its subsequent degradation by polyubiquitination.|||cytoskeleton http://togogenome.org/gene/59894:IP6K1 ^@ http://purl.uniprot.org/uniprot/A0A803VZ50 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/59894:PSMB7 ^@ http://purl.uniprot.org/uniprot/U3JHF2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MFF ^@ http://purl.uniprot.org/uniprot/A0A803VD50|||http://purl.uniprot.org/uniprot/A0A803W4U0|||http://purl.uniprot.org/uniprot/A0A803WEX9|||http://purl.uniprot.org/uniprot/U3JWR7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/59894:CD3E ^@ http://purl.uniprot.org/uniprot/U3JTY0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ALDOC ^@ http://purl.uniprot.org/uniprot/U3JVB0 ^@ Similarity ^@ Belongs to the class I fructose-bisphosphate aldolase family. http://togogenome.org/gene/59894:IMMP1L ^@ http://purl.uniprot.org/uniprot/U3K8J8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26 family.|||Heterodimer of 2 subunits, IMMPL1 and IMMPL2.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:GPN3 ^@ http://purl.uniprot.org/uniprot/U3K3M3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II (RNAPII). May act at an RNAP assembly step prior to nuclear import.|||Small GTPase required for proper nuclear import of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/59894:EIF3L ^@ http://purl.uniprot.org/uniprot/U3KE84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit L family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm http://togogenome.org/gene/59894:CHD7 ^@ http://purl.uniprot.org/uniprot/U3JST3 ^@ Similarity ^@ Belongs to the SNF2/RAD54 helicase family. http://togogenome.org/gene/59894:PRRX1 ^@ http://purl.uniprot.org/uniprot/U3JZK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/59894:VAMP4 ^@ http://purl.uniprot.org/uniprot/A0A803W0B4|||http://purl.uniprot.org/uniprot/U3JZF8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Membrane http://togogenome.org/gene/59894:LOC101817428 ^@ http://purl.uniprot.org/uniprot/U3JV33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/59894:RPL31 ^@ http://purl.uniprot.org/uniprot/U3JMH0 ^@ Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eL31 family.|||Component of the large ribosomal subunit. http://togogenome.org/gene/59894:GOT2 ^@ http://purl.uniprot.org/uniprot/U3JXV9 ^@ Miscellaneous|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||In eukaryotes there are cytoplasmic, mitochondrial and chloroplastic isozymes. http://togogenome.org/gene/59894:LOC101812090 ^@ http://purl.uniprot.org/uniprot/U3JQZ5 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:LCA5 ^@ http://purl.uniprot.org/uniprot/U3JJ15 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/59894:TCP1 ^@ http://purl.uniprot.org/uniprot/U3KC76 ^@ Similarity ^@ Belongs to the TCP-1 chaperonin family. http://togogenome.org/gene/59894:SEMA4D ^@ http://purl.uniprot.org/uniprot/A0A803V672 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TOM1L2 ^@ http://purl.uniprot.org/uniprot/A0A803VKL8|||http://purl.uniprot.org/uniprot/A0A803VMR5|||http://purl.uniprot.org/uniprot/U3KH54 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/59894:DMAP1 ^@ http://purl.uniprot.org/uniprot/U3JRU6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101805850 ^@ http://purl.uniprot.org/uniprot/U3JUT4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:NDUFA11 ^@ http://purl.uniprot.org/uniprot/U3KBY9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the complex I NDUFA11 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SAP130 ^@ http://purl.uniprot.org/uniprot/A0A803VW51|||http://purl.uniprot.org/uniprot/U3JLN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAP130 family.|||Nucleus http://togogenome.org/gene/59894:ACBD5 ^@ http://purl.uniprot.org/uniprot/U3JXK5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acyl-CoA binding protein which acts as the peroxisome receptor for pexophagy but is dispensable for aggrephagy and nonselective autophagy. Binds medium- and long-chain acyl-CoA esters.|||Belongs to the ATG37 family.|||Membrane http://togogenome.org/gene/59894:LOC101819468 ^@ http://purl.uniprot.org/uniprot/U3KF08 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:UIMC1 ^@ http://purl.uniprot.org/uniprot/A0A803VNK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAP80 family.|||Nucleus http://togogenome.org/gene/59894:TMEM192 ^@ http://purl.uniprot.org/uniprot/U3K9G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM192 family.|||Late endosome|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:RAD9A ^@ http://purl.uniprot.org/uniprot/U3KCL2 ^@ Similarity ^@ Belongs to the rad9 family. http://togogenome.org/gene/59894:TTC12 ^@ http://purl.uniprot.org/uniprot/A0A803VZE6|||http://purl.uniprot.org/uniprot/U3JBV7 ^@ Subcellular Location Annotation ^@ A band|||Z line http://togogenome.org/gene/59894:LGI2 ^@ http://purl.uniprot.org/uniprot/A0A803VW82 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:PLA2G12A ^@ http://purl.uniprot.org/uniprot/A0A803VKY8 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:PABPC4 ^@ http://purl.uniprot.org/uniprot/A0A803WA61|||http://purl.uniprot.org/uniprot/U3JCQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the polyadenylate-binding protein type-1 family.|||Binds the poly(A) tail of mRNA.|||Cytoplasm http://togogenome.org/gene/59894:DIS3L ^@ http://purl.uniprot.org/uniprot/U3K610 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNR ribonuclease family.|||Cytoplasm http://togogenome.org/gene/59894:TMEM168 ^@ http://purl.uniprot.org/uniprot/A0A803W5S0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM168 family.|||Membrane http://togogenome.org/gene/59894:SLC12A8 ^@ http://purl.uniprot.org/uniprot/U3KGF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59894:EPN3 ^@ http://purl.uniprot.org/uniprot/A0A803V0I1|||http://purl.uniprot.org/uniprot/A0A803V9G2|||http://purl.uniprot.org/uniprot/U3JF42 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/59894:TEKT3 ^@ http://purl.uniprot.org/uniprot/U3K4G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/59894:HENMT1 ^@ http://purl.uniprot.org/uniprot/U3JJ27 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. HEN1 family. http://togogenome.org/gene/59894:INCENP ^@ http://purl.uniprot.org/uniprot/U3KA79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/59894:CACNG1 ^@ http://purl.uniprot.org/uniprot/U3JIA1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PMP-22/EMP/MP20 family. CACNG subfamily.|||Component of a calcium channel complex consisting of a pore-forming alpha subunit (CACNA1S) and the ancillary subunits CACNB1 or CACNB2, CACNG1 and CACNA2D1. The channel complex contains alpha, beta, gamma and delta subunits in a 1:1:1:1 ratio, i.e. it contains either CACNB1 or CACNB2.|||Membrane|||Regulatory subunit of the voltage-gated calcium channel that gives rise to L-type calcium currents in skeletal muscle. Regulates channel inactivation kinetics.|||sarcolemma http://togogenome.org/gene/59894:ERC2 ^@ http://purl.uniprot.org/uniprot/A0A803VBN2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:FAM83B ^@ http://purl.uniprot.org/uniprot/U3JGK8 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/59894:RPS21 ^@ http://purl.uniprot.org/uniprot/U3K7K9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS21 family.|||Component of the 40S small ribosomal subunit.|||Endoplasmic reticulum|||Rough endoplasmic reticulum|||cytosol http://togogenome.org/gene/59894:UTP23 ^@ http://purl.uniprot.org/uniprot/U3JHY9 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:NLGN3 ^@ http://purl.uniprot.org/uniprot/A0A803V1H4|||http://purl.uniprot.org/uniprot/A0A803VPX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ACSL5 ^@ http://purl.uniprot.org/uniprot/U3JHV3 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/59894:ABHD2 ^@ http://purl.uniprot.org/uniprot/U3K7B2 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/59894:PPP1CB ^@ http://purl.uniprot.org/uniprot/A0A803V127|||http://purl.uniprot.org/uniprot/A0A803W9V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PPP phosphatase family. PP-1 subfamily.|||Cytoplasm http://togogenome.org/gene/59894:SEPT8 ^@ http://purl.uniprot.org/uniprot/U3KG98 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/59894:SLC4A10 ^@ http://purl.uniprot.org/uniprot/A0A803VA55|||http://purl.uniprot.org/uniprot/A0A803VEM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/59894:EP300 ^@ http://purl.uniprot.org/uniprot/U3KC15 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:LOC101818018 ^@ http://purl.uniprot.org/uniprot/U3KLM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CITED4 ^@ http://purl.uniprot.org/uniprot/U3KIP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/59894:CDH18 ^@ http://purl.uniprot.org/uniprot/U3JYJ1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:STT3B ^@ http://purl.uniprot.org/uniprot/A0A803W1F8|||http://purl.uniprot.org/uniprot/U3K3D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STT3 family.|||Membrane http://togogenome.org/gene/59894:NTS ^@ http://purl.uniprot.org/uniprot/A0A803V1D1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurotensin family.|||Neurotensin may play an endocrine or paracrine role in the regulation of fat metabolism. It causes contraction of smooth muscle.|||Secreted|||Vesicle|||secretory vesicle http://togogenome.org/gene/59894:TRPC3 ^@ http://purl.uniprot.org/uniprot/U3K0T3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RAD52 ^@ http://purl.uniprot.org/uniprot/U3JMX6 ^@ Similarity ^@ Belongs to the RAD52 family. http://togogenome.org/gene/59894:LOC101816143 ^@ http://purl.uniprot.org/uniprot/U3JCR1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:SLC18A2 ^@ http://purl.uniprot.org/uniprot/U3JHN5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CACNA2D1 ^@ http://purl.uniprot.org/uniprot/A0A803W702 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/59894:BST1 ^@ http://purl.uniprot.org/uniprot/U3K3V7 ^@ Similarity ^@ Belongs to the ADP-ribosyl cyclase family. http://togogenome.org/gene/59894:ACADL ^@ http://purl.uniprot.org/uniprot/U3KF69 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the acyl-CoA dehydrogenase family.|||Homotetramer.|||Mitochondrion matrix http://togogenome.org/gene/59894:LOC101817697 ^@ http://purl.uniprot.org/uniprot/A0A803VKF9 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59894:LOC101808357 ^@ http://purl.uniprot.org/uniprot/U3JXA2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/59894:EIF4A2 ^@ http://purl.uniprot.org/uniprot/U3K0M2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. eIF4A subfamily. http://togogenome.org/gene/59894:LOC101815382 ^@ http://purl.uniprot.org/uniprot/U3JPA0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ACAD9 ^@ http://purl.uniprot.org/uniprot/U3JB78 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/59894:ST18 ^@ http://purl.uniprot.org/uniprot/A0A803VR75|||http://purl.uniprot.org/uniprot/U3K6H8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/59894:BLCAP ^@ http://purl.uniprot.org/uniprot/U3KLP8 ^@ Similarity ^@ Belongs to the BLCAP family. http://togogenome.org/gene/59894:CHM ^@ http://purl.uniprot.org/uniprot/U3JN06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab GDI family.|||Cytoplasm|||Substrate-binding subunit (component A) of the Rab geranylgeranyltransferase (GGTase) complex. Binds unprenylated Rab proteins and presents the substrate peptide to the catalytic component B. The component A is thought to be regenerated by transferring its prenylated Rab back to the donor membrane. http://togogenome.org/gene/59894:FGF22 ^@ http://purl.uniprot.org/uniprot/U3KHL1 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59894:TMBIM4 ^@ http://purl.uniprot.org/uniprot/U3K609 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BI1 family.|||Membrane http://togogenome.org/gene/59894:PPARG ^@ http://purl.uniprot.org/uniprot/A0A803VB57 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Cytoplasm|||Heterodimer with other nuclear receptors.|||Nuclear receptor that binds peroxisome proliferators such as hypolipidemic drugs and fatty acids. Once activated by a ligand, the nuclear receptor binds to DNA specific PPAR response elements (PPRE) and modulates the transcription of its target genes, such as acyl-CoA oxidase. It therefore controls the peroxisomal beta-oxidation pathway of fatty acids. Key regulator of adipocyte differentiation and glucose homeostasis. May play a role in the regulation of circadian rhythm.|||Nucleus http://togogenome.org/gene/59894:NTNG1 ^@ http://purl.uniprot.org/uniprot/A0A803VC76|||http://purl.uniprot.org/uniprot/A0A803VM89|||http://purl.uniprot.org/uniprot/A0A803VVA2|||http://purl.uniprot.org/uniprot/U3JIT6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CDC42EP1 ^@ http://purl.uniprot.org/uniprot/U3KEH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/59894:CHST15 ^@ http://purl.uniprot.org/uniprot/U3JQ87 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:ABCC2 ^@ http://purl.uniprot.org/uniprot/U3K0G6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:GATA3 ^@ http://purl.uniprot.org/uniprot/U3JGN9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CCDC109B ^@ http://purl.uniprot.org/uniprot/A0A803VT92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCU (TC 1.A.77) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:CLUAP1 ^@ http://purl.uniprot.org/uniprot/A0A803W514 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLUAP1 family.|||cilium http://togogenome.org/gene/59894:TMEM121 ^@ http://purl.uniprot.org/uniprot/U3KJC8 ^@ Similarity ^@ Belongs to the TMEM121 family. http://togogenome.org/gene/59894:PEX16 ^@ http://purl.uniprot.org/uniprot/A0A803WCE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxin-16 family.|||Peroxisome membrane http://togogenome.org/gene/59894:BCL9L ^@ http://purl.uniprot.org/uniprot/U3K5F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/59894:HNF4G ^@ http://purl.uniprot.org/uniprot/A0A803V6U5|||http://purl.uniprot.org/uniprot/A0A803VUR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:CLP1 ^@ http://purl.uniprot.org/uniprot/U3K9D2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Clp1 family. Clp1 subfamily.|||Component of the tRNA splicing endonuclease complex. Component of pre-mRNA cleavage complex II (CF-II).|||Nucleus|||Polynucleotide kinase that can phosphorylate the 5'-hydroxyl groups of double-stranded RNA (dsRNA), single-stranded RNA (ssRNA), double stranded DNA (dsDNA) and double-stranded DNA:RNA hybrids. dsRNA is phosphorylated more efficiently than dsDNA, and the RNA component of a DNA:RNA hybrid is phosphorylated more efficiently than the DNA component. Appears to have roles in both tRNA splicing and mRNA 3'-end formation. Component of the tRNA splicing endonuclease complex. Phosphorylates the 5'-terminus of the tRNA 3'-exon during tRNA splicing; this phosphorylation event is a prerequisite for the subsequent ligation of the two exon halves and the production of a mature tRNA. Component of the pre-mRNA cleavage complex II (CF-II), which seems to be required for mRNA 3'-end formation. Also phosphorylates the 5'-terminus of exogenously introduced short interfering RNAs (siRNAs), which is a necessary prerequisite for their incorporation into the RNA-induced silencing complex (RISC). However, endogenous siRNAs and microRNAs (miRNAs) that are produced by the cleavage of dsRNA precursors by DICER1 already contain a 5'-phosphate group, so this protein may be dispensible for normal RNA-mediated gene silencing. http://togogenome.org/gene/59894:ITGA6 ^@ http://purl.uniprot.org/uniprot/U3JH55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/59894:VAC14 ^@ http://purl.uniprot.org/uniprot/U3JY28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VAC14 family.|||Endosome membrane|||Microsome membrane http://togogenome.org/gene/59894:EMC2 ^@ http://purl.uniprot.org/uniprot/A0A803VJ47 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC2 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. http://togogenome.org/gene/59894:LOC101812030 ^@ http://purl.uniprot.org/uniprot/U3JHE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101820045 ^@ http://purl.uniprot.org/uniprot/U3K6W5 ^@ Similarity ^@ Belongs to the SIMIBI class G3E GTPase family. ZNG1 subfamily. http://togogenome.org/gene/59894:CHRFAM7A ^@ http://purl.uniprot.org/uniprot/A0A803VYW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:MDGA1 ^@ http://purl.uniprot.org/uniprot/U3K9L0 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101808989 ^@ http://purl.uniprot.org/uniprot/U3K401 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:SLC12A1 ^@ http://purl.uniprot.org/uniprot/A0A803VF84|||http://purl.uniprot.org/uniprot/A0A803VFE3|||http://purl.uniprot.org/uniprot/U3KAJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CEP295 ^@ http://purl.uniprot.org/uniprot/U3JBZ5 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/59894:YDJC ^@ http://purl.uniprot.org/uniprot/U3JZL6 ^@ Function|||Similarity ^@ Belongs to the YdjC deacetylase family.|||Probably catalyzes the deacetylation of acetylated carbohydrates an important step in the degradation of oligosaccharides. http://togogenome.org/gene/59894:PEX7 ^@ http://purl.uniprot.org/uniprot/U3KEJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat peroxin-7 family.|||Cytoplasm http://togogenome.org/gene/59894:PDGFC ^@ http://purl.uniprot.org/uniprot/U3JKC5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PDGF/VEGF growth factor family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:MTTP ^@ http://purl.uniprot.org/uniprot/U3JUR9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:MRPS6 ^@ http://purl.uniprot.org/uniprot/U3JR92 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bS6 family. http://togogenome.org/gene/59894:MTMR2 ^@ http://purl.uniprot.org/uniprot/U3JC41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/59894:ADAM19 ^@ http://purl.uniprot.org/uniprot/U3K1B6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ALX4 ^@ http://purl.uniprot.org/uniprot/U3KCT6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:P2RX5 ^@ http://purl.uniprot.org/uniprot/U3JU46 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/59894:RBP7 ^@ http://purl.uniprot.org/uniprot/U3JXQ7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:LOC101806070 ^@ http://purl.uniprot.org/uniprot/U3JXJ8 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:ZER1 ^@ http://purl.uniprot.org/uniprot/A0A803V0G0 ^@ Similarity ^@ Belongs to the zyg-11 family. http://togogenome.org/gene/59894:GTF2A2 ^@ http://purl.uniprot.org/uniprot/U3KDJ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 2 family.|||Nucleus|||TFIIA is a component of the transcription machinery of RNA polymerase II and plays an important role in transcriptional activation. http://togogenome.org/gene/59894:SLC25A37 ^@ http://purl.uniprot.org/uniprot/U3K994 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:CASP3 ^@ http://purl.uniprot.org/uniprot/U3KB70 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/59894:SERPINA10 ^@ http://purl.uniprot.org/uniprot/U3JIJ6 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:SRPRB ^@ http://purl.uniprot.org/uniprot/U3KFS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP receptor beta subunit family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:NDUFB4 ^@ http://purl.uniprot.org/uniprot/A0A803VEW0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB4 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:FAM46D ^@ http://purl.uniprot.org/uniprot/U3KKD3 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/59894:LOC101817249 ^@ http://purl.uniprot.org/uniprot/U3JDR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 6 family.|||Membrane http://togogenome.org/gene/59894:CECR1 ^@ http://purl.uniprot.org/uniprot/U3JK00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. ADGF subfamily.|||Secreted http://togogenome.org/gene/59894:ATG4C ^@ http://purl.uniprot.org/uniprot/U3KDH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C54 family.|||Cysteine protease that plays a key role in autophagy by mediating both proteolytic activation and delipidation of ATG8 family proteins.|||Cytoplasm http://togogenome.org/gene/59894:LOC101820032 ^@ http://purl.uniprot.org/uniprot/U3KIJ9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:DRC7 ^@ http://purl.uniprot.org/uniprot/U3JWQ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC7 family.|||cilium axoneme|||flagellum|||flagellum axoneme http://togogenome.org/gene/59894:CFH ^@ http://purl.uniprot.org/uniprot/A0A803VUS6|||http://purl.uniprot.org/uniprot/U3JJN2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:EBF2 ^@ http://purl.uniprot.org/uniprot/U3K9L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/59894:ZFYVE9 ^@ http://purl.uniprot.org/uniprot/U3JSP6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/59894:POMGNT1 ^@ http://purl.uniprot.org/uniprot/U3K4F9 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 13 family.|||Golgi apparatus membrane|||Membrane|||Participates in O-mannosyl glycosylation by catalyzing the addition of N-acetylglucosamine to O-linked mannose on glycoproteins. Catalyzes the synthesis of the GlcNAc(beta1-2)Man(alpha1-)O-Ser/Thr moiety on alpha-dystroglycan and other O-mannosylated proteins, providing the necessary basis for the addition of further carbohydrate moieties. Is specific for alpha linked terminal mannose.|||The manganese ion interacts primarily with the substrate UDP-N-acetylglucosamine.|||The stem domain mediates specific interaction with beta-linked N-acetylglucosamine moieties of O-glycosylated proteins. It also interacts with its product, N-acetyl-beta-D-glucosaminyl-(1->2)-O-alpha-D-mannosylprotein. http://togogenome.org/gene/59894:SLC5A11 ^@ http://purl.uniprot.org/uniprot/U3JLZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:MAST4 ^@ http://purl.uniprot.org/uniprot/A0A803VIC0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/59894:NTF3 ^@ http://purl.uniprot.org/uniprot/U3JVR8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Secreted|||Seems to promote the survival of visceral and proprioceptive sensory neurons. http://togogenome.org/gene/59894:SLC41A1 ^@ http://purl.uniprot.org/uniprot/U3JCW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/59894:POMK ^@ http://purl.uniprot.org/uniprot/U3JVJ2 ^@ Function|||Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Protein O-mannose kinase that specifically mediates phosphorylation at the 6-position of an O-mannose of the trisaccharide (N-acetylgalactosamine (GalNAc)-beta-1,3-N-acetylglucosamine (GlcNAc)-beta-1,4-mannose) to generate phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-1,3-N-acetylglucosamine-beta-1,4-(phosphate-6-)mannose). Phosphorylated O-mannosyl trisaccharide is a carbohydrate structure present in alpha-dystroglycan (DAG1), which is required for binding laminin G-like domain-containing extracellular proteins with high affinity. Only shows kinase activity when the GalNAc-beta-3-GlcNAc-beta-terminus is linked to the 4-position of O-mannose, suggesting that this disaccharide serves as the substrate recognition motif. http://togogenome.org/gene/59894:FUT7 ^@ http://purl.uniprot.org/uniprot/U3KJK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/59894:NDRG4 ^@ http://purl.uniprot.org/uniprot/A0A803V599|||http://purl.uniprot.org/uniprot/A0A803VTN6|||http://purl.uniprot.org/uniprot/U3JWJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDRG family.|||cytosol http://togogenome.org/gene/59894:CNTNAP5 ^@ http://purl.uniprot.org/uniprot/U3KFG3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||May play a role in the correct development and proper functioning of the peripheral and central nervous system and be involved in cell adhesion and intercellular communication.|||Membrane http://togogenome.org/gene/59894:PSMD13 ^@ http://purl.uniprot.org/uniprot/A0A803V6J9|||http://purl.uniprot.org/uniprot/U3KAD7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S11 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP). The regulatory particle is made of a lid composed of 9 subunits including PSMD13, a base containing 6 ATPases and few additional components.|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/59894:SNX33 ^@ http://purl.uniprot.org/uniprot/U3K880 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Cytoplasmic vesicle membrane http://togogenome.org/gene/59894:TUBGCP5 ^@ http://purl.uniprot.org/uniprot/A0A803VYR5|||http://purl.uniprot.org/uniprot/U3JNA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/59894:ARL5A ^@ http://purl.uniprot.org/uniprot/A0A803W6M7 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59894:UNG ^@ http://purl.uniprot.org/uniprot/U3K2H2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the uracil-DNA glycosylase (UDG) superfamily. UNG family.|||Excises uracil residues from the DNA which can arise as a result of misincorporation of dUMP residues by DNA polymerase or due to deamination of cytosine.|||Mitochondrion|||Nucleus http://togogenome.org/gene/59894:RIOK3 ^@ http://purl.uniprot.org/uniprot/U3JUF5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. RIO-type Ser/Thr kinase family. http://togogenome.org/gene/59894:EXO1 ^@ http://purl.uniprot.org/uniprot/U3KFA7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ 5'->3' double-stranded DNA exonuclease which may also possess a cryptic 3'->5' double-stranded DNA exonuclease activity. Functions in DNA mismatch repair.|||Belongs to the XPG/RAD2 endonuclease family. EXO1 subfamily.|||Binds 2 magnesium ions per subunit. They probably participate in the reaction catalyzed by the enzyme. May bind an additional third magnesium ion after substrate binding.|||Nucleus http://togogenome.org/gene/59894:LOC101810476 ^@ http://purl.uniprot.org/uniprot/U3JF29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101821588 ^@ http://purl.uniprot.org/uniprot/U3JZE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dienelactone hydrolase family.|||cytosol http://togogenome.org/gene/59894:S1PR1 ^@ http://purl.uniprot.org/uniprot/U3KJ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101815404 ^@ http://purl.uniprot.org/uniprot/U3JTQ9 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/59894:KCNH8 ^@ http://purl.uniprot.org/uniprot/U3K3P5 ^@ Subcellular Location Annotation|||Subunit ^@ Membrane|||The potassium channel is probably composed of a homo- or heterotetrameric complex of pore-forming alpha subunits that can associate with modulating beta subunits. http://togogenome.org/gene/59894:NTNG2 ^@ http://purl.uniprot.org/uniprot/U3JFH0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:NT5C2 ^@ http://purl.uniprot.org/uniprot/U3K278 ^@ Cofactor|||Similarity ^@ Belongs to the 5'(3')-deoxyribonucleotidase family.|||Binds 1 Mg(2+) ion per subunit. http://togogenome.org/gene/59894:PBX1 ^@ http://purl.uniprot.org/uniprot/U3JZS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/PBX homeobox family.|||Nucleus http://togogenome.org/gene/59894:LOC101817496 ^@ http://purl.uniprot.org/uniprot/U3K5Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:RFT1 ^@ http://purl.uniprot.org/uniprot/U3JLI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RFT1 family.|||May be involved in N-linked oligosaccharide assembly.|||Membrane http://togogenome.org/gene/59894:TOR4A ^@ http://purl.uniprot.org/uniprot/U3KIE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Membrane http://togogenome.org/gene/59894:ITIH2 ^@ http://purl.uniprot.org/uniprot/U3JGK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/59894:SGTB ^@ http://purl.uniprot.org/uniprot/A0A803VVS2 ^@ Similarity ^@ Belongs to the SGT family. http://togogenome.org/gene/59894:INSIG1 ^@ http://purl.uniprot.org/uniprot/A0A803W7X3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/59894:NUP58 ^@ http://purl.uniprot.org/uniprot/A0A803VWY7|||http://purl.uniprot.org/uniprot/U3K204|||http://purl.uniprot.org/uniprot/U3K205 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/59894:TSPAN32 ^@ http://purl.uniprot.org/uniprot/A0A803VD72 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PFDN4 ^@ http://purl.uniprot.org/uniprot/U3KFG9 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/59894:TMEM45B ^@ http://purl.uniprot.org/uniprot/U3JQP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/59894:TOP1MT ^@ http://purl.uniprot.org/uniprot/U3K4M2 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/59894:PHKA2 ^@ http://purl.uniprot.org/uniprot/A0A803V3Q9|||http://purl.uniprot.org/uniprot/A0A803W5S9|||http://purl.uniprot.org/uniprot/U3JNW1 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/59894:GPR83 ^@ http://purl.uniprot.org/uniprot/U3JC17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:KPNA5 ^@ http://purl.uniprot.org/uniprot/U3K917 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:RPN1 ^@ http://purl.uniprot.org/uniprot/U3JZR5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST1 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Endoplasmic reticulum membrane|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59894:F7 ^@ http://purl.uniprot.org/uniprot/U3JP47 ^@ Caution|||Function|||Subcellular Location Annotation|||Subunit ^@ Heterodimer of a light chain and a heavy chain linked by a disulfide bond.|||Initiates the extrinsic pathway of blood coagulation. Serine protease that circulates in the blood in a zymogen form. Factor VII is converted to factor VIIa by factor Xa, factor XIIa, factor IXa, or thrombin by minor proteolysis. In the presence of tissue factor and calcium ions, factor VIIa then converts factor X to factor Xa by limited proteolysis. Factor VIIa will also convert factor IX to factor IXa in the presence of tissue factor and calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:BUD31 ^@ http://purl.uniprot.org/uniprot/U3KHA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BUD31 (G10) family.|||Nucleus http://togogenome.org/gene/59894:LOC101820119 ^@ http://purl.uniprot.org/uniprot/A0A803VTX7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:CLDN25 ^@ http://purl.uniprot.org/uniprot/U3KJR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:STS ^@ http://purl.uniprot.org/uniprot/A0A803W198|||http://purl.uniprot.org/uniprot/U3JPQ4 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:LOC101817835 ^@ http://purl.uniprot.org/uniprot/U3JZK2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PARL ^@ http://purl.uniprot.org/uniprot/U3JLZ4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TNFSF13B ^@ http://purl.uniprot.org/uniprot/U3JNM9 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/59894:C6H10orf90 ^@ http://purl.uniprot.org/uniprot/U3JEB0 ^@ Subcellular Location Annotation ^@ centrosome http://togogenome.org/gene/59894:AQP1 ^@ http://purl.uniprot.org/uniprot/U3JDI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/59894:UBE2G2 ^@ http://purl.uniprot.org/uniprot/U3JL27 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:LOC101806163 ^@ http://purl.uniprot.org/uniprot/A0A803V4W7 ^@ Similarity ^@ Belongs to the NAD(P)H dehydrogenase (quinone) family. http://togogenome.org/gene/59894:ABLIM2 ^@ http://purl.uniprot.org/uniprot/A0A803VEK7|||http://purl.uniprot.org/uniprot/U3K4Y4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:PRL ^@ http://purl.uniprot.org/uniprot/U3KGG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/59894:ANXA4 ^@ http://purl.uniprot.org/uniprot/U3JBK7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||Zymogen granule membrane http://togogenome.org/gene/59894:JUN ^@ http://purl.uniprot.org/uniprot/U3KL25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. Jun subfamily.|||Nucleus http://togogenome.org/gene/59894:LOC101807389 ^@ http://purl.uniprot.org/uniprot/U3JBR7|||http://purl.uniprot.org/uniprot/U3JNS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:IL4R ^@ http://purl.uniprot.org/uniprot/A0A803V8Q3|||http://purl.uniprot.org/uniprot/A0A803WGR3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for both interleukin 4 and interleukin 13. Couples to the JAK1/2/3-STAT6 pathway. The IL4 response is involved in promoting Th2 differentiation. The IL4/IL13 responses are involved in regulating IgE production and, chemokine and mucus production at sites of allergic inflammation. In certain cell types, can signal through activation of insulin receptor substrates, IRS1/IRS2. http://togogenome.org/gene/59894:KCNV1 ^@ http://purl.uniprot.org/uniprot/U3JHV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the potassium channel family. V (TC 1.A.1.2) subfamily. Kv8.1/KCNV1 sub-subfamily.|||Heteromultimer with KCNB1 and KCNB2. Interacts with KCNC4 and KCND1.|||Membrane|||Potassium channel subunit that does not form functional channels by itself. Modulates KCNB1 and KCNB2 channel activity by shifting the threshold for inactivation to more negative values and by slowing the rate of inactivation. Can down-regulate the channel activity of KCNB1, KCNB2, KCNC4 and KCND1, possibly by trapping them in intracellular membranes. http://togogenome.org/gene/59894:CRBN ^@ http://purl.uniprot.org/uniprot/U3KGI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CRBN family.|||Nucleus http://togogenome.org/gene/59894:FAM149B1 ^@ http://purl.uniprot.org/uniprot/A0A803W091|||http://purl.uniprot.org/uniprot/U3KED3 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/59894:CAPZA2 ^@ http://purl.uniprot.org/uniprot/A0A803W6J0 ^@ Function|||Similarity|||Subunit ^@ Belongs to the F-actin-capping protein alpha subunit family.|||F-actin-capping proteins bind in a Ca(2+)-independent manner to the fast growing ends of actin filaments (barbed end) thereby blocking the exchange of subunits at these ends. Unlike other capping proteins (such as gelsolin and severin), these proteins do not sever actin filaments.|||Heterodimer of an alpha and a beta subunit. http://togogenome.org/gene/59894:ABR ^@ http://purl.uniprot.org/uniprot/U3JUE5 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/59894:SCML4 ^@ http://purl.uniprot.org/uniprot/U3KB42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/59894:TCEA2 ^@ http://purl.uniprot.org/uniprot/U3K6Y6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/59894:GPRC5B ^@ http://purl.uniprot.org/uniprot/A0A803VPE6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:TNPO1 ^@ http://purl.uniprot.org/uniprot/A0A803WG81|||http://purl.uniprot.org/uniprot/U3K6T0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:DOT1L ^@ http://purl.uniprot.org/uniprot/U3KH71 ^@ Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. DOT1 family.|||Histone methyltransferase that specifically trimethylates histone H3 to form H3K79me3. This methylation is required for telomere silencing and for the pachytene checkpoint during the meiotic cell cycle by allowing the recruitment of RAD9 to double strand breaks. Nucleosomes are preferred as substrate compared to free histone.|||In contrast to other lysine histone methyltransferases, it does not contain a SET domain, suggesting the existence of another mechanism for methylation of lysine residues of histones.|||Nucleus http://togogenome.org/gene/59894:TM4SF18 ^@ http://purl.uniprot.org/uniprot/U3JRZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/59894:GABRB2 ^@ http://purl.uniprot.org/uniprot/A0A803VKZ4|||http://purl.uniprot.org/uniprot/U3KGE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:ICT1 ^@ http://purl.uniprot.org/uniprot/U3JEU2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59894:TMEM184A ^@ http://purl.uniprot.org/uniprot/U3KHL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101816078 ^@ http://purl.uniprot.org/uniprot/U3K011 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/59894:FAM171B ^@ http://purl.uniprot.org/uniprot/U3JPH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM171 family.|||Membrane http://togogenome.org/gene/59894:LOC101807822 ^@ http://purl.uniprot.org/uniprot/U3K094 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/59894:RAD51D ^@ http://purl.uniprot.org/uniprot/U3K539 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents.|||Nucleus http://togogenome.org/gene/59894:MFAP3L ^@ http://purl.uniprot.org/uniprot/A0A803V9I9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:CLCN2 ^@ http://purl.uniprot.org/uniprot/A0A803WAA2|||http://purl.uniprot.org/uniprot/U3K0D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-2/CLCN2 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LYRM2 ^@ http://purl.uniprot.org/uniprot/A0A803V3L8 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/59894:JUP ^@ http://purl.uniprot.org/uniprot/U3JC11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-catenin family.|||Membrane|||desmosome http://togogenome.org/gene/59894:STK32C ^@ http://purl.uniprot.org/uniprot/A0A803VKV5|||http://purl.uniprot.org/uniprot/U3JF04 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:LOC101809627 ^@ http://purl.uniprot.org/uniprot/A0A803W991|||http://purl.uniprot.org/uniprot/U3JQP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/59894:GPR161 ^@ http://purl.uniprot.org/uniprot/U3JT86 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:GLRA4 ^@ http://purl.uniprot.org/uniprot/U3K9S6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane http://togogenome.org/gene/59894:ACAA1 ^@ http://purl.uniprot.org/uniprot/U3JVR3 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/59894:C28H19orf25 ^@ http://purl.uniprot.org/uniprot/U3KHX9 ^@ Similarity ^@ Belongs to the UPF0449 family. http://togogenome.org/gene/59894:LOC101819115 ^@ http://purl.uniprot.org/uniprot/U3JBA2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the IL-1 family.|||Monomer.|||Secreted http://togogenome.org/gene/59894:HMOX1 ^@ http://purl.uniprot.org/uniprot/U3KFH1 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/59894:ADGRD1 ^@ http://purl.uniprot.org/uniprot/U3K4M0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:HMGCS2 ^@ http://purl.uniprot.org/uniprot/A0A803VQM2 ^@ Function|||Similarity ^@ Belongs to the thiolase-like superfamily. HMG-CoA synthase family.|||Catalyzes the condensation of acetyl-CoA with acetoacetyl-CoA to form HMG-CoA. http://togogenome.org/gene/59894:HMGB2 ^@ http://purl.uniprot.org/uniprot/U3KAC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome http://togogenome.org/gene/59894:TMEM19 ^@ http://purl.uniprot.org/uniprot/U3K6W3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM19 family.|||Membrane http://togogenome.org/gene/59894:SPSB1 ^@ http://purl.uniprot.org/uniprot/U3JY12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/59894:STAT1 ^@ http://purl.uniprot.org/uniprot/U3JP26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CELF1 ^@ http://purl.uniprot.org/uniprot/A0A803WDT6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CDKL1 ^@ http://purl.uniprot.org/uniprot/A0A803V8C9|||http://purl.uniprot.org/uniprot/U3JGM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:TMLHE ^@ http://purl.uniprot.org/uniprot/U3KAD8 ^@ Similarity ^@ Belongs to the gamma-BBH/TMLD family. http://togogenome.org/gene/59894:DGKG ^@ http://purl.uniprot.org/uniprot/U3JL51 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59894:CORO2B ^@ http://purl.uniprot.org/uniprot/U3K6E2 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/59894:TTC21B ^@ http://purl.uniprot.org/uniprot/U3K152 ^@ Similarity ^@ Belongs to the TTC21 family. http://togogenome.org/gene/59894:CCKAR ^@ http://purl.uniprot.org/uniprot/U3K3E2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for cholecystokinin. Mediates pancreatic growth and enzyme secretion, smooth muscle contraction of the gall bladder and stomach. Has a 1000-fold higher affinity for CCK rather than for gastrin. It modulates feeding and dopamine-induced behavior in the central and peripheral nervous system. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/59894:IFI30 ^@ http://purl.uniprot.org/uniprot/U3KHD7 ^@ Similarity|||Subunit ^@ Belongs to the GILT family.|||Dimer; disulfide-linked. http://togogenome.org/gene/59894:TENM3 ^@ http://purl.uniprot.org/uniprot/U3KAS7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TMCC3 ^@ http://purl.uniprot.org/uniprot/U3K863 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/59894:KPNA3 ^@ http://purl.uniprot.org/uniprot/U3K157 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:MRE11A ^@ http://purl.uniprot.org/uniprot/U3JC18 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MRE11/RAD32 family.|||Involved in DNA double-strand break repair (DSBR). Possesses single-strand endonuclease activity and double-strand-specific 3'-5' exonuclease activity. Also involved in meiotic DSB processing.|||Nucleus http://togogenome.org/gene/59894:AP2A2 ^@ http://purl.uniprot.org/uniprot/A0A803V7A2|||http://purl.uniprot.org/uniprot/U3KBX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Adaptor protein complex 2 (AP-2) is a heterotetramer composed of two large adaptins (alpha-type subunit AP2A1 or AP2A2 and beta-type subunit AP2B1), a medium adaptin (mu-type subunit AP2M1) and a small adaptin (sigma-type subunit AP2S1).|||Belongs to the adaptor complexes large subunit family.|||Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif.|||coated pit http://togogenome.org/gene/59894:CLDN5 ^@ http://purl.uniprot.org/uniprot/U3KJB8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:AP3M1 ^@ http://purl.uniprot.org/uniprot/U3JWY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||Part of the AP-3 complex, an adaptor-related complex which is not clathrin-associated. The complex is associated with the Golgi region as well as more peripheral structures. It facilitates the budding of vesicles from the Golgi membrane and may be directly involved in trafficking to lysosomes. http://togogenome.org/gene/59894:RGS1 ^@ http://purl.uniprot.org/uniprot/U3JLA9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:RAX2 ^@ http://purl.uniprot.org/uniprot/U3KB15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59894:GJC2 ^@ http://purl.uniprot.org/uniprot/U3KK00 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:LOC107604314 ^@ http://purl.uniprot.org/uniprot/U3KK43 ^@ Function ^@ The products of the Gag polyproteins of infectious retroviruses perform highly complex orchestrated tasks during the assembly, budding, maturation, and infection stages of the viral replication cycle. During viral assembly, the proteins form membrane associations and self-associations that ultimately result in budding of an immature virion from the infected cell. Gag precursors also function during viral assembly to selectively bind and package two plus strands of genomic RNA. Endogenous Gag proteins may have kept, lost or modified their original function during evolution. http://togogenome.org/gene/59894:GPR26 ^@ http://purl.uniprot.org/uniprot/U3JQ74 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:CLDN10 ^@ http://purl.uniprot.org/uniprot/A0A803W2T9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:FATE1 ^@ http://purl.uniprot.org/uniprot/U3K9H1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Tango11 family.|||Membrane|||Mitochondrion outer membrane|||Peroxisome|||Plays a role in mitochondrial and peroxisomal fission. Promotes the recruitment and association of the fission mediator dynamin-related protein 1 (DNM1L) to the mitochondrial surface. http://togogenome.org/gene/59894:CLDN34 ^@ http://purl.uniprot.org/uniprot/U3KLB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/59894:FRRS1 ^@ http://purl.uniprot.org/uniprot/U3JI95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRRS1 family.|||Membrane http://togogenome.org/gene/59894:TSC22D1 ^@ http://purl.uniprot.org/uniprot/A0A803W3W3 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/59894:COL4A3BP ^@ http://purl.uniprot.org/uniprot/A0A803W5E9|||http://purl.uniprot.org/uniprot/U3K652 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum|||Golgi apparatus http://togogenome.org/gene/59894:LOC101813582 ^@ http://purl.uniprot.org/uniprot/A0A803WGS8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LAPTM4B ^@ http://purl.uniprot.org/uniprot/A0A803WA76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAPTM4/LAPTM5 transporter family.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Late endosome membrane|||Membrane|||multivesicular body lumen|||multivesicular body membrane http://togogenome.org/gene/59894:ACTR1A ^@ http://purl.uniprot.org/uniprot/U3K221 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:CHD2 ^@ http://purl.uniprot.org/uniprot/U3K709 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101812619 ^@ http://purl.uniprot.org/uniprot/U3KKV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:COQ6 ^@ http://purl.uniprot.org/uniprot/U3JUR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UbiH/COQ6 family.|||Cell projection|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ7.|||FAD-dependent monooxygenase required for the C5-ring hydroxylation during ubiquinone biosynthesis. Catalyzes the hydroxylation of 3-polyprenyl-4-hydroxybenzoic acid to 3-polyprenyl-4,5-dihydroxybenzoic acid. The electrons required for the hydroxylation reaction may be funneled indirectly from NADPH via a ferredoxin/ferredoxin reductase system to COQ6.|||Golgi apparatus|||Mitochondrion inner membrane http://togogenome.org/gene/59894:VPS37B ^@ http://purl.uniprot.org/uniprot/A0A803VS10 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/59894:POSTN ^@ http://purl.uniprot.org/uniprot/A0A803V3C1|||http://purl.uniprot.org/uniprot/A0A803VM61|||http://purl.uniprot.org/uniprot/A0A803VVY2|||http://purl.uniprot.org/uniprot/A0A803VZJ1|||http://purl.uniprot.org/uniprot/A0A803W823|||http://purl.uniprot.org/uniprot/U3K0P5|||http://purl.uniprot.org/uniprot/U3K0P6 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/59894:CLCC1 ^@ http://purl.uniprot.org/uniprot/U3JJ49 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel MCLC family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/59894:PSMB2 ^@ http://purl.uniprot.org/uniprot/A0A803W592 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:NUTF2 ^@ http://purl.uniprot.org/uniprot/A0A803W1L4 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/59894:LOC101810757 ^@ http://purl.uniprot.org/uniprot/U3KKU9 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||Membrane raft|||Secreted http://togogenome.org/gene/59894:FAM13C ^@ http://purl.uniprot.org/uniprot/A0A803VRS6 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/59894:LOC101813135 ^@ http://purl.uniprot.org/uniprot/A0A803VP77|||http://purl.uniprot.org/uniprot/U3JNE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/59894:AGO4 ^@ http://purl.uniprot.org/uniprot/A0A803VPC2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family. Ago subfamily.|||P-body|||Required for RNA-mediated gene silencing (RNAi). Binds to short RNAs such as microRNAs (miRNAs) and represses the translation of mRNAs which are complementary to them. Lacks endonuclease activity and does not appear to cleave target mRNAs. http://togogenome.org/gene/59894:DTYMK ^@ http://purl.uniprot.org/uniprot/A0A803VUG2|||http://purl.uniprot.org/uniprot/U3JKU0 ^@ Similarity ^@ Belongs to the thymidylate kinase family. http://togogenome.org/gene/59894:CLEC16A ^@ http://purl.uniprot.org/uniprot/A0A803WC56|||http://purl.uniprot.org/uniprot/U3JMV4 ^@ Similarity ^@ Belongs to the CLEC16A/gop-1 family. http://togogenome.org/gene/59894:SLC24A1 ^@ http://purl.uniprot.org/uniprot/U3K640 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/59894:TOB1 ^@ http://purl.uniprot.org/uniprot/U3KL30 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/59894:TRPM3 ^@ http://purl.uniprot.org/uniprot/U3K8F4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:WARS ^@ http://purl.uniprot.org/uniprot/U3JJ57 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:FAM49B ^@ http://purl.uniprot.org/uniprot/U3JIR8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/59894:PHTF2 ^@ http://purl.uniprot.org/uniprot/A0A803WEW3|||http://purl.uniprot.org/uniprot/U3K795 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ATP6V0D1 ^@ http://purl.uniprot.org/uniprot/A0A803VWD8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59894:VWC2 ^@ http://purl.uniprot.org/uniprot/A0A803W0F6|||http://purl.uniprot.org/uniprot/U3JYI2 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/59894:STAG1 ^@ http://purl.uniprot.org/uniprot/U3KGB7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/59894:PFDN1 ^@ http://purl.uniprot.org/uniprot/U3K456 ^@ Similarity ^@ Belongs to the prefoldin subunit beta family. http://togogenome.org/gene/59894:EHF ^@ http://purl.uniprot.org/uniprot/A0A803WGI9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:PTP4A1 ^@ http://purl.uniprot.org/uniprot/U3JG42 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59894:CRYBB1 ^@ http://purl.uniprot.org/uniprot/U3K1A4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/59894:SSX2IP ^@ http://purl.uniprot.org/uniprot/U3JUI7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIP family.|||adherens junction|||centriolar satellite http://togogenome.org/gene/59894:ZDHHC7 ^@ http://purl.uniprot.org/uniprot/A0A803V6K2 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:SFN ^@ http://purl.uniprot.org/uniprot/U3KIK8 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:PAFAH1B1 ^@ http://purl.uniprot.org/uniprot/U3JQ84 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LIS1/nudF family.|||Can self-associate. Interacts with dynein, dynactin, NDE1 and NDEL1.|||Dimerization mediated by the LisH domain may be required to activate dynein.|||Positively regulates the activity of the minus-end directed microtubule motor protein dynein. May enhance dynein-mediated microtubule sliding by targeting dynein to the microtubule plus end. Required for several dynein- and microtubule-dependent processes such as the maintenance of Golgi integrity, the peripheral transport of microtubule fragments and the coupling of the nucleus and centrosome. May be required for proliferation of neuronal precursors and neuronal migration.|||centrosome|||cytoskeleton http://togogenome.org/gene/59894:SNU13 ^@ http://purl.uniprot.org/uniprot/A0A803VAE0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL8 family.|||Common component of the spliceosome and rRNA processing machinery.|||nucleolus http://togogenome.org/gene/59894:GTPBP10 ^@ http://purl.uniprot.org/uniprot/U3JZ35 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/59894:DESI2 ^@ http://purl.uniprot.org/uniprot/U3KAG1 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/59894:KAT6A ^@ http://purl.uniprot.org/uniprot/U3JV93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYST (SAS/MOZ) family.|||Nucleus http://togogenome.org/gene/59894:LOC101814279 ^@ http://purl.uniprot.org/uniprot/A0A803W7R1 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:BAZ1B ^@ http://purl.uniprot.org/uniprot/U3KGY4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DARS ^@ http://purl.uniprot.org/uniprot/U3KH56 ^@ Function|||Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 2 subfamily.|||Catalyzes the specific attachment of an amino acid to its cognate tRNA in a 2 step reaction: the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. http://togogenome.org/gene/59894:PTPRA ^@ http://purl.uniprot.org/uniprot/U3JBR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TFDP1 ^@ http://purl.uniprot.org/uniprot/U3JL06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/59894:ECI1 ^@ http://purl.uniprot.org/uniprot/U3JNM4 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/59894:ARG2 ^@ http://purl.uniprot.org/uniprot/U3JRF6 ^@ Cofactor|||Similarity ^@ Belongs to the arginase family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/59894:LOC101807222 ^@ http://purl.uniprot.org/uniprot/A0A803W8L4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/59894:RRAGC ^@ http://purl.uniprot.org/uniprot/U3JE78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/59894:RUNX3 ^@ http://purl.uniprot.org/uniprot/U3JCH7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101813851 ^@ http://purl.uniprot.org/uniprot/A0A803VW25 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/59894:MYF6 ^@ http://purl.uniprot.org/uniprot/U3K7F1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:RTN1 ^@ http://purl.uniprot.org/uniprot/A0A803VPV8|||http://purl.uniprot.org/uniprot/U3JLG2 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:DNAJC2 ^@ http://purl.uniprot.org/uniprot/U3K749 ^@ Subcellular Location Annotation ^@ cytosol http://togogenome.org/gene/59894:ISY1 ^@ http://purl.uniprot.org/uniprot/U3JB70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ISY1 family.|||Nucleus http://togogenome.org/gene/59894:FHL5 ^@ http://purl.uniprot.org/uniprot/A0A803VQX4 ^@ Function|||Subcellular Location Annotation ^@ May be involved in the regulation of spermatogenesis. Stimulates CREM transcriptional activity in a phosphorylation-independent manner.|||Nucleus http://togogenome.org/gene/59894:LOC101811738 ^@ http://purl.uniprot.org/uniprot/U3JC32 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:EPG5 ^@ http://purl.uniprot.org/uniprot/U3K2I9 ^@ Similarity ^@ Belongs to the EPG5 family. http://togogenome.org/gene/59894:THOC5 ^@ http://purl.uniprot.org/uniprot/U3JX82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the THOC5 family.|||Nucleus http://togogenome.org/gene/59894:PLAU ^@ http://purl.uniprot.org/uniprot/U3JX40 ^@ Caution|||Function ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Specifically cleaves the zymogen plasminogen to form the active enzyme plasmin. http://togogenome.org/gene/59894:SLC12A4 ^@ http://purl.uniprot.org/uniprot/A0A803W1Y0|||http://purl.uniprot.org/uniprot/U3JZA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59894:TBX1 ^@ http://purl.uniprot.org/uniprot/A0A803WBD8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:LOC107604579 ^@ http://purl.uniprot.org/uniprot/U3KKH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:LMNB2 ^@ http://purl.uniprot.org/uniprot/U3KBT5 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:JMJD1C ^@ http://purl.uniprot.org/uniprot/U3KFP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CDIP1 ^@ http://purl.uniprot.org/uniprot/A0A803V9K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:TGFB2 ^@ http://purl.uniprot.org/uniprot/U3KCJ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Precursor of the Latency-associated peptide (LAP) and Transforming growth factor beta-2 (TGF-beta-2) chains, which constitute the regulatory and active subunit of TGF-beta-2, respectively.|||extracellular matrix http://togogenome.org/gene/59894:MTERF3 ^@ http://purl.uniprot.org/uniprot/U3JSW8 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/59894:LOC101819992 ^@ http://purl.uniprot.org/uniprot/U3JTK8 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/59894:TRNAU1AP ^@ http://purl.uniprot.org/uniprot/U3JF73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:FASLG ^@ http://purl.uniprot.org/uniprot/A0A803VWN3 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/59894:HAUS3 ^@ http://purl.uniprot.org/uniprot/U3K5J0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HAUS3 family.|||spindle http://togogenome.org/gene/59894:AHCYL1 ^@ http://purl.uniprot.org/uniprot/U3JK14 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/59894:LOC101810724 ^@ http://purl.uniprot.org/uniprot/U3JMR2 ^@ Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A13 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ITPR3 ^@ http://purl.uniprot.org/uniprot/U3JMP8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/59894:DAPK2 ^@ http://purl.uniprot.org/uniprot/U3K7Q3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:SUPT4H1 ^@ http://purl.uniprot.org/uniprot/A0A803W9P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT4 family.|||Nucleus http://togogenome.org/gene/59894:NKX2-5 ^@ http://purl.uniprot.org/uniprot/U3K2D8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NK-2 homeobox family.|||Nucleus http://togogenome.org/gene/59894:USP33 ^@ http://purl.uniprot.org/uniprot/U3JT64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/59894:SGCZ ^@ http://purl.uniprot.org/uniprot/U3JM82 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/59894:PTPRF ^@ http://purl.uniprot.org/uniprot/A0A803VI66 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2A subfamily. http://togogenome.org/gene/59894:HTR2A ^@ http://purl.uniprot.org/uniprot/U3K0P1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasmic vesicle|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin).|||Membrane|||Presynapse|||Synapse|||Vesicle|||axon|||caveola|||dendrite http://togogenome.org/gene/59894:NADSYN1 ^@ http://purl.uniprot.org/uniprot/U3K2E3 ^@ Similarity|||Subunit ^@ Homohexamer.|||In the C-terminal section; belongs to the NAD synthetase family. http://togogenome.org/gene/59894:DFNA5 ^@ http://purl.uniprot.org/uniprot/U3K4L7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:GGT1 ^@ http://purl.uniprot.org/uniprot/A0A803VII8|||http://purl.uniprot.org/uniprot/U3JXW3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:MPV17L ^@ http://purl.uniprot.org/uniprot/A0A803VR44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/59894:LOC101812558 ^@ http://purl.uniprot.org/uniprot/U3KLQ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59894:CTSD ^@ http://purl.uniprot.org/uniprot/A0A803W730 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/59894:LOC101817738 ^@ http://purl.uniprot.org/uniprot/U3JLE8 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Activity on G(z)-alpha is inhibited by phosphorylation of the G-protein. Activity on G(z)-alpha and G(i)-alpha-1 is inhibited by palmitoylation of the G-protein. http://togogenome.org/gene/59894:GSG1L2 ^@ http://purl.uniprot.org/uniprot/U3JD63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/59894:BCHE ^@ http://purl.uniprot.org/uniprot/U3K1Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Secreted http://togogenome.org/gene/59894:FLCN ^@ http://purl.uniprot.org/uniprot/U3KH81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the folliculin family.|||Lysosome membrane|||Membrane|||Nucleus|||centrosome|||cilium|||cytosol|||spindle http://togogenome.org/gene/59894:CACNB2 ^@ http://purl.uniprot.org/uniprot/A0A803V6M7|||http://purl.uniprot.org/uniprot/A0A803VD88|||http://purl.uniprot.org/uniprot/U3JY84 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calcium channel beta subunit family.|||The beta subunit of voltage-dependent calcium channels contributes to the function of the calcium channel by increasing peak calcium current, shifting the voltage dependencies of activation and inactivation, modulating G protein inhibition and controlling the alpha-1 subunit membrane targeting.|||sarcolemma http://togogenome.org/gene/59894:TRAM2 ^@ http://purl.uniprot.org/uniprot/A0A803V835 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAM family.|||Membrane http://togogenome.org/gene/59894:LPIN3 ^@ http://purl.uniprot.org/uniprot/U3JSN6 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/59894:KYNU ^@ http://purl.uniprot.org/uniprot/U3KHE1 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kynureninase family.|||Catalyzes the cleavage of L-kynurenine (L-Kyn) and L-3-hydroxykynurenine (L-3OHKyn) into anthranilic acid (AA) and 3-hydroxyanthranilic acid (3-OHAA), respectively.|||Cytoplasm|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TMEM63C ^@ http://purl.uniprot.org/uniprot/U3KE70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/59894:PAMR1 ^@ http://purl.uniprot.org/uniprot/U3KD97 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:HOXA3 ^@ http://purl.uniprot.org/uniprot/U3K4C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59894:LOC101806491 ^@ http://purl.uniprot.org/uniprot/U3JXI4 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:AACS ^@ http://purl.uniprot.org/uniprot/U3K466 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Converts acetoacetate to acetoacetyl-CoA in the cytosol.|||cytosol http://togogenome.org/gene/59894:ADGRG6 ^@ http://purl.uniprot.org/uniprot/U3KE79|||http://purl.uniprot.org/uniprot/U3KE83 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101810182 ^@ http://purl.uniprot.org/uniprot/U3KGI2 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/59894:TRMT10C ^@ http://purl.uniprot.org/uniprot/U3KIJ8 ^@ Subcellular Location Annotation ^@ mitochondrion nucleoid http://togogenome.org/gene/59894:LOC101819523 ^@ http://purl.uniprot.org/uniprot/U3JPE8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:TGM2 ^@ http://purl.uniprot.org/uniprot/U3JPG0 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/59894:GCNT4 ^@ http://purl.uniprot.org/uniprot/U3KJH5 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101817657 ^@ http://purl.uniprot.org/uniprot/U3K493 ^@ Similarity ^@ Belongs to the NSG family. http://togogenome.org/gene/59894:DES ^@ http://purl.uniprot.org/uniprot/U3JNV6 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LOC101815505 ^@ http://purl.uniprot.org/uniprot/A0A803VZN8|||http://purl.uniprot.org/uniprot/U3JY14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/59894:LOC101813769 ^@ http://purl.uniprot.org/uniprot/U3KHS7 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/59894:MARK1 ^@ http://purl.uniprot.org/uniprot/U3KC51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/59894:TEAD1 ^@ http://purl.uniprot.org/uniprot/A0A803W3I7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PRKD1 ^@ http://purl.uniprot.org/uniprot/A0A803VW26|||http://purl.uniprot.org/uniprot/U3JT98 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:LOC107603309 ^@ http://purl.uniprot.org/uniprot/A0A803V9X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/59894:GDF2 ^@ http://purl.uniprot.org/uniprot/A0A803W295 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/59894:PSAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VPU4 ^@ Function|||Similarity ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. SerC subfamily.|||Catalyzes the reversible conversion of 3-phosphohydroxypyruvate to phosphoserine and of 3-hydroxy-2-oxo-4-phosphonooxybutanoate to phosphohydroxythreonine. http://togogenome.org/gene/59894:LOC101810111 ^@ http://purl.uniprot.org/uniprot/U3JPC1 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/59894:ACAT1 ^@ http://purl.uniprot.org/uniprot/U3JCG5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/59894:SNTB2 ^@ http://purl.uniprot.org/uniprot/U3JJJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntrophin family.|||Cell junction|||cytoskeleton http://togogenome.org/gene/59894:KPNA6 ^@ http://purl.uniprot.org/uniprot/U3JCX6 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:INPP5A ^@ http://purl.uniprot.org/uniprot/A0A803VGZ2|||http://purl.uniprot.org/uniprot/A0A803WAW6 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type I family. http://togogenome.org/gene/59894:AGXT ^@ http://purl.uniprot.org/uniprot/U3JLI2 ^@ Similarity|||Subunit ^@ Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer. http://togogenome.org/gene/59894:SPDL1 ^@ http://purl.uniprot.org/uniprot/U3K4Y9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Spindly family.|||Required for the localization of dynein and dynactin to the mitotic kintochore. Dynein is believed to control the initial lateral interaction between the kinetochore and spindle microtubules and to facilitate the subsequent formation of end-on kinetochore-microtubule attachments mediated by the NDC80 complex.|||kinetochore http://togogenome.org/gene/59894:LYRM4 ^@ http://purl.uniprot.org/uniprot/U3KFD8 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/59894:CFLAR ^@ http://purl.uniprot.org/uniprot/U3JNF5 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/59894:SMC1B ^@ http://purl.uniprot.org/uniprot/A0A803W7M8|||http://purl.uniprot.org/uniprot/U3JJH0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC1 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/59894:INPP5K ^@ http://purl.uniprot.org/uniprot/U3JW08 ^@ Similarity ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family. http://togogenome.org/gene/59894:GATC ^@ http://purl.uniprot.org/uniprot/A0A803VE07|||http://purl.uniprot.org/uniprot/A0A803VRI0|||http://purl.uniprot.org/uniprot/A0A803W3U0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the GatC family.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/59894:GPR68 ^@ http://purl.uniprot.org/uniprot/U3KJ90 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:SLC25A24 ^@ http://purl.uniprot.org/uniprot/U3JJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:LLGL2 ^@ http://purl.uniprot.org/uniprot/U3JEF7 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/59894:MEF2A ^@ http://purl.uniprot.org/uniprot/A0A803VKY5|||http://purl.uniprot.org/uniprot/A0A803W6G6|||http://purl.uniprot.org/uniprot/U3K6U1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SEPT3 ^@ http://purl.uniprot.org/uniprot/U3KB83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cytoplasm http://togogenome.org/gene/59894:PHACTR3 ^@ http://purl.uniprot.org/uniprot/U3K7Y7 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/59894:FAM102A ^@ http://purl.uniprot.org/uniprot/U3JEZ9 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/59894:TMEM59L ^@ http://purl.uniprot.org/uniprot/U3K444 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:GDPD4 ^@ http://purl.uniprot.org/uniprot/U3JYR2 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/59894:P2RX1 ^@ http://purl.uniprot.org/uniprot/U3K5D0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/59894:NUDT1 ^@ http://purl.uniprot.org/uniprot/U3KHL3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family.|||Monomer.|||Nucleus http://togogenome.org/gene/59894:ACE2 ^@ http://purl.uniprot.org/uniprot/U3JP73 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase M2 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Membrane|||Secreted|||cilium http://togogenome.org/gene/59894:ZFPM2 ^@ http://purl.uniprot.org/uniprot/A0A803VMS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:KIFC3 ^@ http://purl.uniprot.org/uniprot/A0A803WCY7|||http://purl.uniprot.org/uniprot/U3JWP3 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:NDE1 ^@ http://purl.uniprot.org/uniprot/U3KI17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/59894:NCOA2 ^@ http://purl.uniprot.org/uniprot/U3K118 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/59894:CYGB ^@ http://purl.uniprot.org/uniprot/U3JDW8 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:ADCK3 ^@ http://purl.uniprot.org/uniprot/A0A803WDB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Membrane|||Mitochondrion http://togogenome.org/gene/59894:INTS2 ^@ http://purl.uniprot.org/uniprot/U3JSH9 ^@ Similarity ^@ Belongs to the Integrator subunit 2 family. http://togogenome.org/gene/59894:DUS4L ^@ http://purl.uniprot.org/uniprot/A0A803VGD6 ^@ Function|||Similarity ^@ Belongs to the dus family.|||Catalyzes the synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. http://togogenome.org/gene/59894:CD38 ^@ http://purl.uniprot.org/uniprot/U3K3U0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADP-ribosyl cyclase family.|||Membrane http://togogenome.org/gene/59894:SLBP ^@ http://purl.uniprot.org/uniprot/U3K5Y6 ^@ Similarity ^@ Belongs to the SLBP family. http://togogenome.org/gene/59894:NKIRAS1 ^@ http://purl.uniprot.org/uniprot/A0A803W135 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/59894:LHFP ^@ http://purl.uniprot.org/uniprot/A0A803V1N6|||http://purl.uniprot.org/uniprot/A0A803V1Y4|||http://purl.uniprot.org/uniprot/U3K1S3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MRPL14 ^@ http://purl.uniprot.org/uniprot/A0A803W0M4|||http://purl.uniprot.org/uniprot/U3K9V9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL14 family. http://togogenome.org/gene/59894:KMT2A ^@ http://purl.uniprot.org/uniprot/U3K5T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. TRX/MLL subfamily.|||Nucleus http://togogenome.org/gene/59894:HOXA6 ^@ http://purl.uniprot.org/uniprot/U3K496 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59894:ANO10 ^@ http://purl.uniprot.org/uniprot/U3K3B9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:ZC3H12B ^@ http://purl.uniprot.org/uniprot/A0A803VGB8 ^@ Similarity ^@ Belongs to the ZC3H12 family. http://togogenome.org/gene/59894:OXSM ^@ http://purl.uniprot.org/uniprot/U3K3H5 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Beta-ketoacyl-ACP synthases family. http://togogenome.org/gene/59894:CDH10 ^@ http://purl.uniprot.org/uniprot/U3JYV7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ERN1 ^@ http://purl.uniprot.org/uniprot/U3JHZ6 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:OSBP ^@ http://purl.uniprot.org/uniprot/U3KCE6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:TOM1L1 ^@ http://purl.uniprot.org/uniprot/U3JHU9 ^@ Similarity ^@ Belongs to the TOM1 family. http://togogenome.org/gene/59894:FAH ^@ http://purl.uniprot.org/uniprot/U3JTC8 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/59894:FAM105A ^@ http://purl.uniprot.org/uniprot/A0A803V8M5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/59894:KCTD10 ^@ http://purl.uniprot.org/uniprot/A0A803VCP3 ^@ Similarity ^@ Belongs to the BACURD family. http://togogenome.org/gene/59894:TMEM135 ^@ http://purl.uniprot.org/uniprot/U3JZI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM135 family.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/59894:SV2C ^@ http://purl.uniprot.org/uniprot/U3K616 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:LOC101805840 ^@ http://purl.uniprot.org/uniprot/U3KF98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59894:CDH20 ^@ http://purl.uniprot.org/uniprot/U3KER3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:KIAA1024L ^@ http://purl.uniprot.org/uniprot/U3JQK2 ^@ Similarity ^@ Belongs to the MINAR family. http://togogenome.org/gene/59894:AHCY ^@ http://purl.uniprot.org/uniprot/U3K7P0 ^@ Similarity ^@ Belongs to the adenosylhomocysteinase family. http://togogenome.org/gene/59894:SMC6 ^@ http://purl.uniprot.org/uniprot/U3JGJ5 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/59894:MRPL42 ^@ http://purl.uniprot.org/uniprot/U3K829 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL42 family.|||Mitochondrion http://togogenome.org/gene/59894:AGO2 ^@ http://purl.uniprot.org/uniprot/U3JJK4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the argonaute family. Ago subfamily.|||Component of the RISC loading complex (RLC), or micro-RNA (miRNA) loading complex (miRLC), which is composed of dicer1, ago2 and tarbp2. Note that the trimeric RLC/miRLC is also referred to as RISC.|||P-body|||Required for RNA-mediated gene silencing (RNAi) by the RNA-induced silencing complex (RISC). The 'minimal RISC' appears to include ago2 bound to a short guide RNA such as a microRNA (miRNA) or short interfering RNA (siRNA). These guide RNAs direct RISC to complementary mRNAs that are targets for RISC-mediated gene silencing. The precise mechanism of gene silencing depends on the degree of complementarity between the miRNA or siRNA and its target. Binding of RISC to a perfectly complementary mRNA generally results in silencing due to endonucleolytic cleavage of the mRNA specifically by ago2. Binding of RISC to a partially complementary mRNA results in silencing through inhibition of translation, and this is independent of endonuclease activity. The inhibition of translational initiation leads to the accumulation of the affected mRNA in cytoplasmic processing bodies (P-bodies), where mRNA degradation may subsequently occur.|||The Piwi domain may perform RNA cleavage by a mechanism similar to that of RNase H. However, while RNase H utilizes a triad of Asp-Asp-Glu (DDE) for metal ion coordination, this protein appears to utilize a triad of Asp-Asp-His (DDH). http://togogenome.org/gene/59894:LOC101817530 ^@ http://purl.uniprot.org/uniprot/A0A803V6P6|||http://purl.uniprot.org/uniprot/U3KBM8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ALAS1 ^@ http://purl.uniprot.org/uniprot/U3K2P9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:FAM13B ^@ http://purl.uniprot.org/uniprot/A0A803VFE9|||http://purl.uniprot.org/uniprot/A0A803W6K7|||http://purl.uniprot.org/uniprot/U3JYV2 ^@ Similarity ^@ Belongs to the FAM13 family. http://togogenome.org/gene/59894:EGFL7 ^@ http://purl.uniprot.org/uniprot/U3JG62 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:NCAPG ^@ http://purl.uniprot.org/uniprot/A0A803VZ60|||http://purl.uniprot.org/uniprot/U3K3M1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND3 (condensin subunit 3) family.|||Chromosome http://togogenome.org/gene/59894:LOC101805866 ^@ http://purl.uniprot.org/uniprot/U3KKT9 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:CNOT7 ^@ http://purl.uniprot.org/uniprot/A0A803WA75|||http://purl.uniprot.org/uniprot/U3KA11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/59894:DNAJC24 ^@ http://purl.uniprot.org/uniprot/A0A803VTH6 ^@ Similarity ^@ Belongs to the DPH4 family. http://togogenome.org/gene/59894:GAB3 ^@ http://purl.uniprot.org/uniprot/U3JBQ6 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/59894:TMEM200C ^@ http://purl.uniprot.org/uniprot/U3KIF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/59894:XRCC3 ^@ http://purl.uniprot.org/uniprot/U3JJP3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. RAD51 subfamily.|||Cytoplasm|||Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA, thought to repair chromosomal fragmentation, translocations and deletions.|||Nucleus http://togogenome.org/gene/59894:CLCF1 ^@ http://purl.uniprot.org/uniprot/U3KCL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-6 superfamily.|||Secreted http://togogenome.org/gene/59894:SMPD2 ^@ http://purl.uniprot.org/uniprot/U3JLY9 ^@ Similarity ^@ Belongs to the neutral sphingomyelinase family. http://togogenome.org/gene/59894:ADGRL4 ^@ http://purl.uniprot.org/uniprot/U3JTU8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:BRD1 ^@ http://purl.uniprot.org/uniprot/U3K4S9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ZPBP2 ^@ http://purl.uniprot.org/uniprot/U3JCJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zona pellucida-binding protein Sp38 family.|||Secreted http://togogenome.org/gene/59894:PSMA2 ^@ http://purl.uniprot.org/uniprot/U3JR95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Nucleus http://togogenome.org/gene/59894:RIBC2 ^@ http://purl.uniprot.org/uniprot/U3JJI7 ^@ Similarity ^@ Belongs to the RIB43A family. http://togogenome.org/gene/59894:LOC101808646 ^@ http://purl.uniprot.org/uniprot/U3JHQ2 ^@ Similarity ^@ Belongs to the avidin/streptavidin family. http://togogenome.org/gene/59894:ARPC1A ^@ http://purl.uniprot.org/uniprot/U3KHB4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/59894:TNFRSF1A ^@ http://purl.uniprot.org/uniprot/U3JRP8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:PDCD4 ^@ http://purl.uniprot.org/uniprot/U3JHX1 ^@ Similarity ^@ Belongs to the PDCD4 family. http://togogenome.org/gene/59894:VPS54 ^@ http://purl.uniprot.org/uniprot/A0A803VQD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS54 family.|||trans-Golgi network http://togogenome.org/gene/59894:LOC101809951 ^@ http://purl.uniprot.org/uniprot/A0A803WEA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/59894:HSPA13 ^@ http://purl.uniprot.org/uniprot/A0A803VK83 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/59894:EFEMP1 ^@ http://purl.uniprot.org/uniprot/U3K9I7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:RAMP2 ^@ http://purl.uniprot.org/uniprot/U3JD90 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/59894:LOC101813356 ^@ http://purl.uniprot.org/uniprot/A0A803VTC6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:LOC101821454 ^@ http://purl.uniprot.org/uniprot/A0A803VEB6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ACVR1B ^@ http://purl.uniprot.org/uniprot/U3JBE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/59894:MMP2 ^@ http://purl.uniprot.org/uniprot/U3JZN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/59894:IL2RB ^@ http://purl.uniprot.org/uniprot/A0A803VPU9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Cell membrane|||Membrane|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit. Interacts with SHB upon interleukin stimulation. http://togogenome.org/gene/59894:LOC107603375 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:FAM73B ^@ http://purl.uniprot.org/uniprot/U3JFD5 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/59894:ADAMTS10 ^@ http://purl.uniprot.org/uniprot/U3KHA9 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:CORO6 ^@ http://purl.uniprot.org/uniprot/A0A803V964|||http://purl.uniprot.org/uniprot/A0A803WAV2|||http://purl.uniprot.org/uniprot/U3JUP6 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/59894:CCNJ ^@ http://purl.uniprot.org/uniprot/A0A803VSF2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59894:OSBPL1A ^@ http://purl.uniprot.org/uniprot/A0A803V6N1|||http://purl.uniprot.org/uniprot/U3JU89 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:CDH11 ^@ http://purl.uniprot.org/uniprot/U3JYU1 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:USP2 ^@ http://purl.uniprot.org/uniprot/U3JU75 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:LOC101807778 ^@ http://purl.uniprot.org/uniprot/U3JU59 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GALE ^@ http://purl.uniprot.org/uniprot/U3JCM4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family.|||Catalyzes two distinct but analogous reactions: the reversible epimerization of UDP-glucose to UDP-galactose and the reversible epimerization of UDP-N-acetylglucosamine to UDP-N-acetylgalactosamine. The reaction with UDP-Gal plays a critical role in the Leloir pathway of galactose catabolism in which galactose is converted to the glycolytic intermediate glucose 6-phosphate. It contributes to the catabolism of dietary galactose and enables the endogenous biosynthesis of both UDP-Gal and UDP-GalNAc when exogenous sources are limited. Both UDP-sugar interconversions are important in the synthesis of glycoproteins and glycolipids.|||Homodimer. http://togogenome.org/gene/59894:LOC101813216 ^@ http://purl.uniprot.org/uniprot/A0A803WD27|||http://purl.uniprot.org/uniprot/U3JSG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:CHRNA4 ^@ http://purl.uniprot.org/uniprot/U3K764 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:CHGB ^@ http://purl.uniprot.org/uniprot/A0A803V1B9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/59894:ND5 ^@ http://purl.uniprot.org/uniprot/S0AU87 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 5 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:CELF5 ^@ http://purl.uniprot.org/uniprot/U3KHI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:LOC101811319 ^@ http://purl.uniprot.org/uniprot/A0A803V7C4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/59894:CHST3 ^@ http://purl.uniprot.org/uniprot/A0A803V2V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/59894:L3MBTL2 ^@ http://purl.uniprot.org/uniprot/A0A803VEE4|||http://purl.uniprot.org/uniprot/U3KC09 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Nucleus|||Part of the E2F6.com-1 complex in G0 phase composed of E2F6, MGA, MAX, TFDP1, CBX3, BAT8, EUHMTASE1, RING1, RNF2, MBLR, BAT8 and YAF2.|||Putative Polycomb group (PcG) protein. PcG proteins maintain the transcriptionally repressive state of genes, probably via a modification of chromatin, rendering it heritably changed in its expressibility. Its association with a chromatin-remodeling complex suggests that it may contribute to prevent expression of genes that trigger the cell into mitosis. Binds to monomethylated and dimethylated 'Lys-20' on histone H4. Binds histone H3 peptides that are monomethylated or dimethylated on 'Lys-4', 'Lys-9' or 'Lys-27'. http://togogenome.org/gene/59894:CNOT1 ^@ http://purl.uniprot.org/uniprot/A0A803V0X9|||http://purl.uniprot.org/uniprot/U3JXV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT1 family.|||Nucleus http://togogenome.org/gene/59894:TAF9B ^@ http://purl.uniprot.org/uniprot/U3JNC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family.|||Nucleus http://togogenome.org/gene/59894:PLD4 ^@ http://purl.uniprot.org/uniprot/A0A803WET2|||http://purl.uniprot.org/uniprot/U3JK22 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/59894:POLG ^@ http://purl.uniprot.org/uniprot/U3K7F2 ^@ Function|||Subcellular Location Annotation ^@ Involved in the replication of mitochondrial DNA. Associates with mitochondrial DNA.|||mitochondrion nucleoid http://togogenome.org/gene/59894:HSPB1 ^@ http://purl.uniprot.org/uniprot/U3K4N8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||spindle http://togogenome.org/gene/59894:ZNF326 ^@ http://purl.uniprot.org/uniprot/U3JG34 ^@ Similarity ^@ Belongs to the AKAP95 family. http://togogenome.org/gene/59894:CXCL12 ^@ http://purl.uniprot.org/uniprot/U3JYP3 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:FGF8 ^@ http://purl.uniprot.org/uniprot/A0A803VJP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Secreted http://togogenome.org/gene/59894:SCRN1 ^@ http://purl.uniprot.org/uniprot/U3K3X6 ^@ Similarity ^@ Belongs to the peptidase C69 family. Secernin subfamily. http://togogenome.org/gene/59894:APAF1 ^@ http://purl.uniprot.org/uniprot/U3K8W9 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Monomer. Oligomerizes upon binding of cytochrome c and dATP.|||Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. http://togogenome.org/gene/59894:BDKRB2 ^@ http://purl.uniprot.org/uniprot/U3KK45 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Forms a complex with PECAM1 and GNAQ. Interacts with PECAM1.|||Membrane|||Receptor for bradykinin. It is associated with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/59894:LOC101813502 ^@ http://purl.uniprot.org/uniprot/A0A803VEI8 ^@ Similarity ^@ Belongs to the 'GDXG' lipolytic enzyme family. http://togogenome.org/gene/59894:ADRM1 ^@ http://purl.uniprot.org/uniprot/U3K7M4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADRM1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ANAPC11 ^@ http://purl.uniprot.org/uniprot/A0A803W2Y4 ^@ Similarity ^@ Belongs to the RING-box family. http://togogenome.org/gene/59894:LOC101812477 ^@ http://purl.uniprot.org/uniprot/A0A803W1N6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:RBPJ ^@ http://purl.uniprot.org/uniprot/A0A803VXK3|||http://purl.uniprot.org/uniprot/A0A803WEI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Su(H) family.|||Nucleus http://togogenome.org/gene/59894:LRRC16A ^@ http://purl.uniprot.org/uniprot/A0A803VZT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CARMIL family.|||Cytoplasm http://togogenome.org/gene/59894:ABCC9 ^@ http://purl.uniprot.org/uniprot/A0A803V1K6|||http://purl.uniprot.org/uniprot/A0A803V5P9|||http://purl.uniprot.org/uniprot/A0A803VE12|||http://purl.uniprot.org/uniprot/U3JLS9 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/59894:LOC101817172 ^@ http://purl.uniprot.org/uniprot/U3KIB0 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:CEPT1 ^@ http://purl.uniprot.org/uniprot/A0A803VIZ5|||http://purl.uniprot.org/uniprot/A0A803VRX7|||http://purl.uniprot.org/uniprot/U3JIF1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/59894:KIAA2022 ^@ http://purl.uniprot.org/uniprot/A0A803VRN3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101819072 ^@ http://purl.uniprot.org/uniprot/U3KKQ5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:MFAP3 ^@ http://purl.uniprot.org/uniprot/A0A803V5D9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:AARS ^@ http://purl.uniprot.org/uniprot/U3JXK4 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/59894:LOC101817188 ^@ http://purl.uniprot.org/uniprot/A0A803VII0 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/59894:CENPN ^@ http://purl.uniprot.org/uniprot/A0A803VY48|||http://purl.uniprot.org/uniprot/U3JWH7|||http://purl.uniprot.org/uniprot/U3JWH9 ^@ Similarity ^@ Belongs to the CENP-N/CHL4 family. http://togogenome.org/gene/59894:GOLM1 ^@ http://purl.uniprot.org/uniprot/A0A803V808|||http://purl.uniprot.org/uniprot/U3JLQ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLM family.|||Membrane http://togogenome.org/gene/59894:MPP6 ^@ http://purl.uniprot.org/uniprot/A0A803WBA7|||http://purl.uniprot.org/uniprot/U3K4M1 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/59894:ZC2HC1C ^@ http://purl.uniprot.org/uniprot/A0A803WBN5|||http://purl.uniprot.org/uniprot/U3JV16 ^@ Similarity ^@ Belongs to the ZC2HC1 family. http://togogenome.org/gene/59894:ZBED4 ^@ http://purl.uniprot.org/uniprot/U3KLI7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CAST ^@ http://purl.uniprot.org/uniprot/U3JJW9 ^@ Function|||Similarity ^@ Belongs to the protease inhibitor I27 (calpastatin) family.|||Specific inhibition of calpain (calcium-dependent cysteine protease). Plays a key role in postmortem tenderization of meat and have been proposed to be involved in muscle protein degradation in living tissue. http://togogenome.org/gene/59894:EIF5A2 ^@ http://purl.uniprot.org/uniprot/U3K1P3 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-5A family.|||Endoplasmic reticulum membrane|||eIF-5A seems to be the only eukaryotic protein to have a hypusine residue which is a post-translational modification of a lysine by the addition of a butylamino group.|||mRNA-binding protein involved in translation elongation. Has an important function at the level of mRNA turnover, probably acting downstream of decapping. Critical for the efficient synthesis of peptide bonds between consecutive proline residues. Can resolve ribosomal stalling caused by consecutive prolines during translation. Involved in actin dynamics and cell cycle progression, mRNA decay and probably in a pathway involved in stress response and maintenance of cell wall integrity. Functions as a regulator of apoptosis. http://togogenome.org/gene/59894:LOC101809792 ^@ http://purl.uniprot.org/uniprot/A0A803V348 ^@ Similarity ^@ Belongs to the DeSI family. http://togogenome.org/gene/59894:PCMTD1 ^@ http://purl.uniprot.org/uniprot/U3K6E7 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/59894:SLC15A4 ^@ http://purl.uniprot.org/uniprot/U3K4A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Membrane http://togogenome.org/gene/59894:LIPC ^@ http://purl.uniprot.org/uniprot/U3KCN1 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:PPP1R12A ^@ http://purl.uniprot.org/uniprot/A0A803W6A6|||http://purl.uniprot.org/uniprot/U3K7D7 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||PP1 comprises a catalytic subunit, and one or several targeting or regulatory subunits. http://togogenome.org/gene/59894:DBNDD2 ^@ http://purl.uniprot.org/uniprot/A0A803V6B0 ^@ Similarity ^@ Belongs to the dysbindin family. http://togogenome.org/gene/59894:HESX1 ^@ http://purl.uniprot.org/uniprot/U3K1E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANF homeobox family.|||Nucleus http://togogenome.org/gene/59894:CXXC5 ^@ http://purl.uniprot.org/uniprot/U3K4B7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:PIK3CA ^@ http://purl.uniprot.org/uniprot/U3K146 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/59894:SEC16B ^@ http://purl.uniprot.org/uniprot/U3K0R9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/59894:LOC101810295 ^@ http://purl.uniprot.org/uniprot/U3JIK4 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:CDCP2 ^@ http://purl.uniprot.org/uniprot/U3KC08 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LCLAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VED9|||http://purl.uniprot.org/uniprot/A0A803WA02 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:OSBPL9 ^@ http://purl.uniprot.org/uniprot/A0A803VMM7|||http://purl.uniprot.org/uniprot/U3JSE7 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:LOC101819083 ^@ http://purl.uniprot.org/uniprot/U3KIW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:SLC37A1 ^@ http://purl.uniprot.org/uniprot/U3JGY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/59894:ARF3 ^@ http://purl.uniprot.org/uniprot/A0A803W6I5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/59894:RAB3IL1 ^@ http://purl.uniprot.org/uniprot/A0A803W750|||http://purl.uniprot.org/uniprot/U3JPC4 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/59894:CHFR ^@ http://purl.uniprot.org/uniprot/U3K0M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHFR family.|||PML body http://togogenome.org/gene/59894:LOC101817598 ^@ http://purl.uniprot.org/uniprot/U3JRU4 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:GAS8 ^@ http://purl.uniprot.org/uniprot/U3JK25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC4 family.|||flagellum axoneme http://togogenome.org/gene/59894:LOC101818147 ^@ http://purl.uniprot.org/uniprot/A0A803VW13 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:LOC101813370 ^@ http://purl.uniprot.org/uniprot/U3KJV8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:PAQR8 ^@ http://purl.uniprot.org/uniprot/U3KKB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59894:PKP1 ^@ http://purl.uniprot.org/uniprot/A0A803V103|||http://purl.uniprot.org/uniprot/U3JIK1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/59894:PDZD2 ^@ http://purl.uniprot.org/uniprot/U3JHK1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Homotetramer.|||Interleukin-16 stimulates a migratory response in CD4+ lymphocytes, monocytes, and eosinophils. Primes CD4+ T-cells for IL-2 and IL-15 responsiveness. Also induces T-lymphocyte expression of interleukin 2 receptor. Ligand for CD4.|||Nucleus|||Secreted http://togogenome.org/gene/59894:SLC15A2 ^@ http://purl.uniprot.org/uniprot/U3KFQ0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the major facilitator superfamily. Proton-dependent oligopeptide transporter (POT/PTR) (TC 2.A.17) family.|||Interacts (via extracellular domain region) with trypsin.|||Membrane http://togogenome.org/gene/59894:HPGD ^@ http://purl.uniprot.org/uniprot/A0A803VGL9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:APITD1 ^@ http://purl.uniprot.org/uniprot/U3JXN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF9 family. CENP-S/MHF1 subfamily.|||Nucleus|||kinetochore http://togogenome.org/gene/59894:ALDH3A2 ^@ http://purl.uniprot.org/uniprot/A0A803VBJ5|||http://purl.uniprot.org/uniprot/A0A803W156 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:FAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VYL1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LRWD1 ^@ http://purl.uniprot.org/uniprot/U3K4G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRWD1 family.|||centrosome|||kinetochore|||telomere http://togogenome.org/gene/59894:SLC12A9 ^@ http://purl.uniprot.org/uniprot/U3JZ57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59894:DNASE1L3 ^@ http://purl.uniprot.org/uniprot/U3K0W3 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/59894:CPEB4 ^@ http://purl.uniprot.org/uniprot/A0A803V8D8 ^@ Similarity ^@ Belongs to the RRM CPEB family. http://togogenome.org/gene/59894:FAM3D ^@ http://purl.uniprot.org/uniprot/A0A803WGF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/59894:CDK3 ^@ http://purl.uniprot.org/uniprot/U3JE29 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:BVES ^@ http://purl.uniprot.org/uniprot/U3KAQ3 ^@ Similarity ^@ Belongs to the popeye family. http://togogenome.org/gene/59894:GABRB1 ^@ http://purl.uniprot.org/uniprot/U3JK16 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:GJA9 ^@ http://purl.uniprot.org/uniprot/U3KIP0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:GABARAPL2 ^@ http://purl.uniprot.org/uniprot/U3JIL3 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59894:ARRB1 ^@ http://purl.uniprot.org/uniprot/U3JUQ6 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/59894:PDE4D ^@ http://purl.uniprot.org/uniprot/A0A803V6H3|||http://purl.uniprot.org/uniprot/A0A803WA13|||http://purl.uniprot.org/uniprot/A0A803WCW9|||http://purl.uniprot.org/uniprot/U3K8Z6 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:LOC101818225 ^@ http://purl.uniprot.org/uniprot/A0A803WD01 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/59894:SSTR2 ^@ http://purl.uniprot.org/uniprot/U3KKU3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Homodimer and heterodimer with SSTR3 and SSTR5. Heterodimerization with SSTR3 inactivates SSTR3 receptor function. Heterodimerization with SSTR5 is enhanced by agonist stimulation of SSTR2 and increases SSTR2 cell growth inhibition activity. Following agonist stimulation, homodimers dissociate into monomers which is required for receptor internalization. Interacts with beta-arrestin; this interaction is necessary for receptor internalization and is destabilized by heterodimerization with SSTR5 which results in increased recycling of SSTR2 to the cell surface. Interacts (via C-terminus) with SHANK1 (via PDZ domain).|||Membrane|||Receptor for somatostatin-14 and -28. This receptor is coupled via pertussis toxin sensitive G proteins to inhibition of adenylyl cyclase. In addition it stimulates phosphotyrosine phosphatase and PLC via pertussis toxin insensitive as well as sensitive G proteins. Inhibits calcium entry by suppressing voltage-dependent calcium channels. Acts as the functionally dominant somatostatin receptor in pancreatic alpha- and beta-cells where it mediates the inhibitory effect of somatostatin-14 on hormone secretion. Inhibits cell growth through enhancement of MAPK1 and MAPK2 phosphorylation and subsequent up-regulation of CDKN1B. Stimulates neuronal migration and axon outgrowth and may participate in neuron development and maturation during brain development. Mediates negative regulation of insulin receptor signaling through PTPN6. Inactivates SSTR3 receptor function following heterodimerization. http://togogenome.org/gene/59894:NIPBL ^@ http://purl.uniprot.org/uniprot/A0A803VM48|||http://purl.uniprot.org/uniprot/U3JH84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCC2/Nipped-B family.|||Nucleus http://togogenome.org/gene/59894:PRR5L ^@ http://purl.uniprot.org/uniprot/U3KD80 ^@ Similarity ^@ Belongs to the PROTOR family. http://togogenome.org/gene/59894:CSNK1G2 ^@ http://purl.uniprot.org/uniprot/A0A803VHL4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/59894:MED27 ^@ http://purl.uniprot.org/uniprot/U3JFG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 27 family.|||Nucleus http://togogenome.org/gene/59894:POC5 ^@ http://purl.uniprot.org/uniprot/U3K617 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the POC5 family.|||Essential for the assembly of the distal half of centrioles, required for centriole elongation.|||centriole http://togogenome.org/gene/59894:PEPD ^@ http://purl.uniprot.org/uniprot/U3JZB3 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/59894:ELAVL2 ^@ http://purl.uniprot.org/uniprot/A0A803VLA9|||http://purl.uniprot.org/uniprot/A0A803WAH9 ^@ Similarity ^@ Belongs to the RRM elav family. http://togogenome.org/gene/59894:NEU4 ^@ http://purl.uniprot.org/uniprot/A0A803V6Z1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/59894:ATP4B ^@ http://purl.uniprot.org/uniprot/U3JL40 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/59894:LOC101813401 ^@ http://purl.uniprot.org/uniprot/U3KKV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:ATP5S ^@ http://purl.uniprot.org/uniprot/U3JGL7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATP synthase subunit s family.|||Homotetramer. Associates with ATP synthase.|||Involved in regulation of mitochondrial membrane ATP synthase. Necessary for H(+) conduction of ATP synthase. Facilitates energy-driven catalysis of ATP synthesis by blocking a proton leak through an alternative proton exit pathway.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:HCK ^@ http://purl.uniprot.org/uniprot/U3JSC9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:LOC101814140 ^@ http://purl.uniprot.org/uniprot/A0A803VNQ1|||http://purl.uniprot.org/uniprot/U3JMN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:SMC5 ^@ http://purl.uniprot.org/uniprot/A0A803V3Z0|||http://purl.uniprot.org/uniprot/U3JQ61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC5 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/59894:KCNA1 ^@ http://purl.uniprot.org/uniprot/U3KKD6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SLC27A6 ^@ http://purl.uniprot.org/uniprot/U3JQP0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:SLC18B1 ^@ http://purl.uniprot.org/uniprot/U3KBE7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ARPC1B ^@ http://purl.uniprot.org/uniprot/U3KHB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ARPC1 family.|||Functions as component of the Arp2/3 complex which is involved in regulation of actin polymerization and together with an activating nucleation-promoting factor (NPF) mediates the formation of branched actin networks.|||Nucleus|||cytoskeleton http://togogenome.org/gene/59894:LOC101817763 ^@ http://purl.uniprot.org/uniprot/A0A803W610 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:MC2R ^@ http://purl.uniprot.org/uniprot/U3KIH0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MRAP; increasing ligand-sensitivity and generation of cAMP. Interacts with MRAP2; competing with MRAP for binding to MC2R and impairing the binding of corticotropin (ACTH).|||Membrane http://togogenome.org/gene/59894:PLCB2 ^@ http://purl.uniprot.org/uniprot/U3JED2 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/59894:RPS11 ^@ http://purl.uniprot.org/uniprot/U3K072 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS17 family. http://togogenome.org/gene/59894:TRDMT1 ^@ http://purl.uniprot.org/uniprot/U3JYD3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. http://togogenome.org/gene/59894:ZDHHC9 ^@ http://purl.uniprot.org/uniprot/U3KB32 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:BORA ^@ http://purl.uniprot.org/uniprot/U3JE63 ^@ Similarity ^@ Belongs to the BORA family. http://togogenome.org/gene/59894:HS6ST2 ^@ http://purl.uniprot.org/uniprot/U3JGK2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/59894:CORIN ^@ http://purl.uniprot.org/uniprot/U3JK73 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:SH3GL2 ^@ http://purl.uniprot.org/uniprot/U3JK71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Membrane http://togogenome.org/gene/59894:LOC101815656 ^@ http://purl.uniprot.org/uniprot/U3KAC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:ALKBH8 ^@ http://purl.uniprot.org/uniprot/A0A803V7C5|||http://purl.uniprot.org/uniprot/U3JCI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkB family.|||Cytoplasm http://togogenome.org/gene/59894:GALNT4 ^@ http://purl.uniprot.org/uniprot/U3KK81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:GSX1 ^@ http://purl.uniprot.org/uniprot/A0A803VF76 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:OGDHL ^@ http://purl.uniprot.org/uniprot/A0A803VKA9|||http://purl.uniprot.org/uniprot/U3JW96 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/59894:HAS2 ^@ http://purl.uniprot.org/uniprot/A0A803VI94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NodC/HAS family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane http://togogenome.org/gene/59894:NSDHL ^@ http://purl.uniprot.org/uniprot/U3KA43 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59894:DNAJA4 ^@ http://purl.uniprot.org/uniprot/U3K7S7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MRPS30 ^@ http://purl.uniprot.org/uniprot/U3K9K2 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59894:SMAD2 ^@ http://purl.uniprot.org/uniprot/A0A803VG84|||http://purl.uniprot.org/uniprot/U3K2R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:DEGS1 ^@ http://purl.uniprot.org/uniprot/A0A803VBK6|||http://purl.uniprot.org/uniprot/U3KBC2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cornichon family.|||Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane|||Interacts with RLBP1; the interaction increases synthesis of chromophore-precursors by DEGS1.|||Membrane http://togogenome.org/gene/59894:MFSD10 ^@ http://purl.uniprot.org/uniprot/U3K5C1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ATP6V0D2 ^@ http://purl.uniprot.org/uniprot/U3JQR8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase V0D/AC39 subunit family.|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59894:CRKL ^@ http://purl.uniprot.org/uniprot/A0A803V182 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/59894:MTMR6 ^@ http://purl.uniprot.org/uniprot/U3K206 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/59894:LOC101808809 ^@ http://purl.uniprot.org/uniprot/U3JXR9 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:LLGL1 ^@ http://purl.uniprot.org/uniprot/U3KH40 ^@ Similarity ^@ Belongs to the WD repeat L(2)GL family. http://togogenome.org/gene/59894:LOC101816713 ^@ http://purl.uniprot.org/uniprot/U3JWY7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/59894:B4GALNT4 ^@ http://purl.uniprot.org/uniprot/U3KAH7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane|||Transfers N-acetylgalactosamine (GalNAc) from UDP-GalNAc to N-acetylglucosamine-beta-benzyl with a beta-1,4-linkage to form N,N'-diacetyllactosediamine, GalNAc-beta-1,4-GlcNAc structures in N-linked glycans and probably O-linked glycans. http://togogenome.org/gene/59894:YIPF7 ^@ http://purl.uniprot.org/uniprot/U3JJU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Membrane http://togogenome.org/gene/59894:SMARCA2 ^@ http://purl.uniprot.org/uniprot/U3K786 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/59894:DDX47 ^@ http://purl.uniprot.org/uniprot/U3KA38 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX47/RRP3 subfamily. http://togogenome.org/gene/59894:LOC101815602 ^@ http://purl.uniprot.org/uniprot/U3JNE7 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/59894:EMC6 ^@ http://purl.uniprot.org/uniprot/U3KL55 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC6 family.|||Component of the ER membrane protein complex (EMC).|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MTX2 ^@ http://purl.uniprot.org/uniprot/U3JKN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metaxin family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:NDUFB6 ^@ http://purl.uniprot.org/uniprot/U3JQ18 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB6 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SERPINC1 ^@ http://purl.uniprot.org/uniprot/U3JJZ3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the serpin family.|||Forms protease inhibiting heterodimer with TMPRSS7.|||extracellular space http://togogenome.org/gene/59894:LOC101815467 ^@ http://purl.uniprot.org/uniprot/U3K8N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:C1QA ^@ http://purl.uniprot.org/uniprot/U3K740 ^@ Function ^@ C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. http://togogenome.org/gene/59894:DCN ^@ http://purl.uniprot.org/uniprot/A0A803VLS0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class I subfamily.|||Binds to type I and type II collagen, fibronectin and TGF-beta. Forms a ternary complex with MFAP2 and ELN.|||May affect the rate of fibrils formation.|||extracellular matrix http://togogenome.org/gene/59894:HCRTR2 ^@ http://purl.uniprot.org/uniprot/U3JGK6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ZDHHC15 ^@ http://purl.uniprot.org/uniprot/U3K8J1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:TRIQK ^@ http://purl.uniprot.org/uniprot/U3JS46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRIQK family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LOC101814354 ^@ http://purl.uniprot.org/uniprot/U3KF64 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:AGPAT5 ^@ http://purl.uniprot.org/uniprot/A0A803VKD5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:TUBB2B ^@ http://purl.uniprot.org/uniprot/U3KFA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:DOCK5 ^@ http://purl.uniprot.org/uniprot/A0A803W4S7|||http://purl.uniprot.org/uniprot/U3K9F7 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/59894:CZH18orf32 ^@ http://purl.uniprot.org/uniprot/U3K2U3 ^@ Similarity ^@ Belongs to the UPF0729 family. http://togogenome.org/gene/59894:CDH12 ^@ http://purl.uniprot.org/uniprot/U3JYQ4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:HMGCL ^@ http://purl.uniprot.org/uniprot/A0A803W454 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/59894:IDH1 ^@ http://purl.uniprot.org/uniprot/U3JLZ0 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/59894:MYLK ^@ http://purl.uniprot.org/uniprot/U3KG18 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. http://togogenome.org/gene/59894:SERPINB5 ^@ http://purl.uniprot.org/uniprot/U3KEX6 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/59894:ARL6IP5 ^@ http://purl.uniprot.org/uniprot/A0A803VTP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PRA1 family.|||Membrane http://togogenome.org/gene/59894:USP9X ^@ http://purl.uniprot.org/uniprot/U3JFP5 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:AASS ^@ http://purl.uniprot.org/uniprot/U3K5Q9 ^@ Similarity ^@ In the C-terminal section; belongs to the saccharopine dehydrogenase family.|||In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/59894:NSF ^@ http://purl.uniprot.org/uniprot/U3JYQ3 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Binds 1 Mg(2+) ion per subunit.|||Cytoplasm|||Required for vesicle-mediated transport. Catalyzes the fusion of transport vesicles within the Golgi cisternae. Is also required for transport from the endoplasmic reticulum to the Golgi stack. Seems to function as a fusion protein required for the delivery of cargo proteins to all compartments of the Golgi stack independent of vesicle origin. http://togogenome.org/gene/59894:LOC101815220 ^@ http://purl.uniprot.org/uniprot/A0A803VZC4|||http://purl.uniprot.org/uniprot/U3KKA2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101813797 ^@ http://purl.uniprot.org/uniprot/U3KA49 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:DOK5 ^@ http://purl.uniprot.org/uniprot/U3K8T5 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/59894:CFAP206 ^@ http://purl.uniprot.org/uniprot/U3JJT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP206 family.|||cilium axoneme|||cilium basal body http://togogenome.org/gene/59894:LOC101815407 ^@ http://purl.uniprot.org/uniprot/A0A803V8R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/59894:TSEN15 ^@ http://purl.uniprot.org/uniprot/U3JKD0 ^@ Similarity ^@ Belongs to the SEN15 family. http://togogenome.org/gene/59894:LOC101806551 ^@ http://purl.uniprot.org/uniprot/U3KB63 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:GRHPR ^@ http://purl.uniprot.org/uniprot/U3KET3 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/59894:SLC22A2 ^@ http://purl.uniprot.org/uniprot/U3KBU9 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/59894:CTNS ^@ http://purl.uniprot.org/uniprot/U3JU08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cystinosin family.|||Membrane http://togogenome.org/gene/59894:TEX10 ^@ http://purl.uniprot.org/uniprot/U3JQL2 ^@ Similarity ^@ Belongs to the IPI1/TEX10 family. http://togogenome.org/gene/59894:HSPA5 ^@ http://purl.uniprot.org/uniprot/U3JHL5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:LOC101811072 ^@ http://purl.uniprot.org/uniprot/U3JYH0 ^@ Similarity ^@ Belongs to the DNA photolyase class-2 family. http://togogenome.org/gene/59894:MYBL1 ^@ http://purl.uniprot.org/uniprot/A0A803VJL6|||http://purl.uniprot.org/uniprot/U3JSB1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101813448 ^@ http://purl.uniprot.org/uniprot/U3K440 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DENR ^@ http://purl.uniprot.org/uniprot/A0A803VX47 ^@ Similarity ^@ Belongs to the DENR family. http://togogenome.org/gene/59894:GOSR2 ^@ http://purl.uniprot.org/uniprot/U3JYT1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PCYT2 ^@ http://purl.uniprot.org/uniprot/U3KBN1 ^@ Similarity ^@ Belongs to the cytidylyltransferase family. http://togogenome.org/gene/59894:PTPRT ^@ http://purl.uniprot.org/uniprot/A0A803VLK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/59894:LPIN1 ^@ http://purl.uniprot.org/uniprot/A0A803VM34|||http://purl.uniprot.org/uniprot/A0A803VUE8|||http://purl.uniprot.org/uniprot/U3JW89|||http://purl.uniprot.org/uniprot/U3JW93 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/59894:RIDA ^@ http://purl.uniprot.org/uniprot/U3JT39 ^@ Function|||Similarity ^@ Belongs to the RutC family.|||Catalyzes the hydrolytic deamination of enamine/imine intermediates that form during the course of normal metabolism. May facilitate the release of ammonia from these potentially toxic reactive metabolites, reducing their impact on cellular components. It may act on enamine/imine intermediates formed by several types of pyridoxal-5'-phosphate-dependent dehydratases including L-threonine dehydratase. http://togogenome.org/gene/59894:TP53INP1 ^@ http://purl.uniprot.org/uniprot/A0A803W9E8 ^@ Subcellular Location Annotation ^@ PML body|||autophagosome|||cytosol http://togogenome.org/gene/59894:PAX3 ^@ http://purl.uniprot.org/uniprot/U3JW66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/59894:SLU7 ^@ http://purl.uniprot.org/uniprot/U3KGA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associated with the spliceosome.|||Belongs to the SLU7 family.|||Involved in pre-mRNA splicing.|||Nucleus http://togogenome.org/gene/59894:RPL6 ^@ http://purl.uniprot.org/uniprot/U3K2U5 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL6 family. http://togogenome.org/gene/59894:EXOSC2 ^@ http://purl.uniprot.org/uniprot/U3JFF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRP4 family.|||Cytoplasm http://togogenome.org/gene/59894:LOC101821004 ^@ http://purl.uniprot.org/uniprot/U3JYQ1 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:NDUFAF1 ^@ http://purl.uniprot.org/uniprot/A0A803V036|||http://purl.uniprot.org/uniprot/U3JUA6 ^@ Function|||Similarity ^@ As part of the MCIA complex, involved in the assembly of the mitochondrial complex I.|||Belongs to the CIA30 family. http://togogenome.org/gene/59894:IK ^@ http://purl.uniprot.org/uniprot/U3K4F8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RED family.|||Nucleus http://togogenome.org/gene/59894:LOC101820004 ^@ http://purl.uniprot.org/uniprot/A0A803W8R7 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/59894:PPP2R5A ^@ http://purl.uniprot.org/uniprot/U3KD64 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/59894:LOC101811833 ^@ http://purl.uniprot.org/uniprot/U3JK02 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Generally pentameric. There are five types of GABA(A) receptor chains: alpha, beta, gamma, delta, and rho. Interacts with SQSTM1.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:NRP2 ^@ http://purl.uniprot.org/uniprot/A0A803VLF5|||http://purl.uniprot.org/uniprot/U3JMJ3 ^@ Caution|||Similarity ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:FNIP2 ^@ http://purl.uniprot.org/uniprot/A0A803VMD4|||http://purl.uniprot.org/uniprot/A0A803WCF6|||http://purl.uniprot.org/uniprot/U3JK41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:ACSL4 ^@ http://purl.uniprot.org/uniprot/U3JBM6 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:FAM214B ^@ http://purl.uniprot.org/uniprot/A0A803W1C8 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/59894:SUMO1 ^@ http://purl.uniprot.org/uniprot/A0A803V4V3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin family. SUMO subfamily.|||Nucleus http://togogenome.org/gene/59894:SEC23A ^@ http://purl.uniprot.org/uniprot/U3JUH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:CPNE1 ^@ http://purl.uniprot.org/uniprot/A0A803WDD8|||http://purl.uniprot.org/uniprot/U3KDF2 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/59894:ABHD3 ^@ http://purl.uniprot.org/uniprot/U3JUH7 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 4 family. http://togogenome.org/gene/59894:LOC101810223 ^@ http://purl.uniprot.org/uniprot/U3KFT7 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/59894:GRIA4 ^@ http://purl.uniprot.org/uniprot/U3JCE2|||http://purl.uniprot.org/uniprot/U3JCE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:SETD3 ^@ http://purl.uniprot.org/uniprot/U3JIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. SETD3 actin-histidine methyltransferase family.|||Cytoplasm http://togogenome.org/gene/59894:NKX2-1 ^@ http://purl.uniprot.org/uniprot/U3JUF7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:BRIX1 ^@ http://purl.uniprot.org/uniprot/U3JHD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BRX1 family.|||Required for biogenesis of the 60S ribosomal subunit.|||nucleolus http://togogenome.org/gene/59894:UNC5C ^@ http://purl.uniprot.org/uniprot/A0A803VKJ6|||http://purl.uniprot.org/uniprot/A0A803VMX3|||http://purl.uniprot.org/uniprot/U3JUI2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/59894:YIPF1 ^@ http://purl.uniprot.org/uniprot/U3KBV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Endosome membrane|||Late endosome membrane|||Membrane|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:OGDH ^@ http://purl.uniprot.org/uniprot/A0A803V864|||http://purl.uniprot.org/uniprot/A0A803VM64|||http://purl.uniprot.org/uniprot/A0A803VY84|||http://purl.uniprot.org/uniprot/U3JBA0 ^@ Similarity ^@ Belongs to the alpha-ketoglutarate dehydrogenase family. http://togogenome.org/gene/59894:CSNK1G1 ^@ http://purl.uniprot.org/uniprot/A0A803V2X2|||http://purl.uniprot.org/uniprot/A0A803W0R8|||http://purl.uniprot.org/uniprot/U3K5C8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CK1 Ser/Thr protein kinase family. Casein kinase I subfamily. http://togogenome.org/gene/59894:LOC101815619 ^@ http://purl.uniprot.org/uniprot/U3K4F1 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:PDIK1L ^@ http://purl.uniprot.org/uniprot/A0A803V3Q3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:TUBG1 ^@ http://purl.uniprot.org/uniprot/U3JD73 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules. The gamma chain is found at microtubule organizing centers (MTOC) such as the spindle poles or the centrosome.|||centrosome http://togogenome.org/gene/59894:ZNF503 ^@ http://purl.uniprot.org/uniprot/U3JWT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Elbow/Noc family.|||Nucleus http://togogenome.org/gene/59894:EIF2D ^@ http://purl.uniprot.org/uniprot/U3JCT0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF2D family.|||Cytoplasm|||Translation initiation factor that is able to deliver tRNA to the P-site of the eukaryotic ribosome in a GTP-independent manner. The binding of Met-tRNA(I) occurs after the AUG codon finds its position in the P-site of 40S ribosomes, the situation that takes place during initiation complex formation on some specific RNAs. Its activity in tRNA binding with 40S subunits does not require the presence of the aminoacyl moiety. Possesses the unique ability to deliver non-Met (elongator) tRNAs into the P-site of the 40S subunit. In addition to its role in initiation, can promote release of deacylated tRNA and mRNA from recycled 40S subunits following ABCE1-mediated dissociation of post-termination ribosomal complexes into subunits. http://togogenome.org/gene/59894:PDX1 ^@ http://purl.uniprot.org/uniprot/U3K1Q7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ZBTB8OS ^@ http://purl.uniprot.org/uniprot/U3JCW6 ^@ Similarity|||Subunit ^@ Belongs to the archease family.|||Component of the tRNA-splicing ligase complex. http://togogenome.org/gene/59894:TDRD9 ^@ http://purl.uniprot.org/uniprot/U3JJT2 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/59894:DST ^@ http://purl.uniprot.org/uniprot/A0A803VNZ6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:PLPPR3 ^@ http://purl.uniprot.org/uniprot/U3KHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/59894:CD81 ^@ http://purl.uniprot.org/uniprot/A0A803VNP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:BRAF ^@ http://purl.uniprot.org/uniprot/U3JMB6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/59894:ARMC1 ^@ http://purl.uniprot.org/uniprot/A0A803WFV9 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||In association with mitochondrial contact site and cristae organizing system (MICOS) complex components and mitochondrial outer membrane sorting assembly machinery (SAM) complex components may regulate mitochondrial dynamics playing a role in determining mitochondrial length, distribution and motility.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:GAL ^@ http://purl.uniprot.org/uniprot/U3KDP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the galanin family.|||Secreted http://togogenome.org/gene/59894:PLXNB1 ^@ http://purl.uniprot.org/uniprot/U3KE08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PAPOLA ^@ http://purl.uniprot.org/uniprot/A0A803W7Q5|||http://purl.uniprot.org/uniprot/U3JIP5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the poly(A) polymerase family.|||Binds 2 magnesium ions. Also active with manganese.|||Nucleus|||Polymerase that creates the 3'-poly(A) tail of mRNA's. http://togogenome.org/gene/59894:PPP1R3B ^@ http://purl.uniprot.org/uniprot/U3JW92 ^@ Subunit ^@ Interacts with glycogen, PPP1CC catalytic subunit of PP1 and PYGL. Associates with glycogen particles. Forms complexes with debranching enzyme, glycogen phosphorylase, glycogen synthase and phosphorylase kinase which is necessary for its regulation of PP1 activity. http://togogenome.org/gene/59894:LOC101818422 ^@ http://purl.uniprot.org/uniprot/U3JTE6 ^@ Similarity ^@ Belongs to the CDC50/LEM3 family. http://togogenome.org/gene/59894:HMBOX1 ^@ http://purl.uniprot.org/uniprot/A0A803V9X8|||http://purl.uniprot.org/uniprot/U3K8H7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CYTB ^@ http://purl.uniprot.org/uniprot/Q7HN24 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b family.|||Binds 2 heme groups non-covalently.|||Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex) that is part of the mitochondrial respiratory chain. The b-c1 complex mediates electron transfer from ubiquinol to cytochrome c. Contributes to the generation of a proton gradient across the mitochondrial membrane that is then used for ATP synthesis.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:PPEF1 ^@ http://purl.uniprot.org/uniprot/U3JNX7 ^@ Similarity ^@ Belongs to the PPP phosphatase family. http://togogenome.org/gene/59894:LOC101807521 ^@ http://purl.uniprot.org/uniprot/A0A803VID5 ^@ Similarity ^@ Belongs to the GST superfamily. Theta family. http://togogenome.org/gene/59894:RGS9BP ^@ http://purl.uniprot.org/uniprot/U3KIF9 ^@ Similarity ^@ Belongs to the RGS7BP/RGS9BP family. http://togogenome.org/gene/59894:SVEP1 ^@ http://purl.uniprot.org/uniprot/U3JBS0 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:KCNE4 ^@ http://purl.uniprot.org/uniprot/U3KLC2 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/59894:ALG12 ^@ http://purl.uniprot.org/uniprot/U3K4T2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the eighth mannose residue in an alpha-1,6 linkage onto the dolichol-PP-oligosaccharide precursor (dolichol-PP-Man(7)GlcNAc(2)) required for protein glycosylation.|||Belongs to the glycosyltransferase 22 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MTHFD2L ^@ http://purl.uniprot.org/uniprot/U3K0C1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CCDC94 ^@ http://purl.uniprot.org/uniprot/U3JEA5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CWC16 family. YJU2 subfamily.|||Component of the spliceosome. Present in the activated B complex, the catalytically activated B* complex which catalyzes the branching, the catalytic step 1 C complex catalyzing the exon ligation, and the postcatalytic P complex containing the ligated exons (mRNA) and the excised lariat intron.|||Nucleus|||Part of the spliceosome which catalyzes two sequential transesterification reactions, first the excision of the non-coding intron from pre-mRNA and then the ligation of the coding exons to form the mature mRNA. Plays a role in stabilizing the structure of the spliceosome catalytic core and docking of the branch helix into the active site, producing 5'-exon and lariat intron-3'-intermediates. May protect cells from TP53-dependent apoptosis upon dsDNA break damage through association with PRP19-CD5L complex. http://togogenome.org/gene/59894:DHODH ^@ http://purl.uniprot.org/uniprot/U3JJ10 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.|||Binds 1 FMN per subunit.|||Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor. Required for UMP biosynthesis via de novo pathway.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:CELF6 ^@ http://purl.uniprot.org/uniprot/U3K4Q6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SLC6A1 ^@ http://purl.uniprot.org/uniprot/U3JB51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:GALNT1 ^@ http://purl.uniprot.org/uniprot/U3JPI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:DAO ^@ http://purl.uniprot.org/uniprot/U3K2I4 ^@ Similarity ^@ Belongs to the DAMOX/DASOX family. http://togogenome.org/gene/59894:KCNK2 ^@ http://purl.uniprot.org/uniprot/U3KCS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59894:UBE2T ^@ http://purl.uniprot.org/uniprot/A0A803VSI6|||http://purl.uniprot.org/uniprot/U3JIB3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:CASC1 ^@ http://purl.uniprot.org/uniprot/A0A803VM62 ^@ Similarity ^@ Belongs to the DNAI7 family. http://togogenome.org/gene/59894:RAB18 ^@ http://purl.uniprot.org/uniprot/A0A803VMQ5 ^@ Subcellular Location Annotation ^@ Apical cell membrane|||Cell membrane|||Lipid droplet http://togogenome.org/gene/59894:LOC101810905 ^@ http://purl.uniprot.org/uniprot/U3KG76 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:NAP1L1 ^@ http://purl.uniprot.org/uniprot/U3K745 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/59894:DRD4 ^@ http://purl.uniprot.org/uniprot/U3K8S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:STEAP1 ^@ http://purl.uniprot.org/uniprot/A0A803VPJ3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PTTG1 ^@ http://purl.uniprot.org/uniprot/U3KGA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the securin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CAV1 ^@ http://purl.uniprot.org/uniprot/U3K695 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||Membrane raft|||caveola http://togogenome.org/gene/59894:DCP1A ^@ http://purl.uniprot.org/uniprot/U3K225 ^@ Similarity ^@ Belongs to the DCP1 family. http://togogenome.org/gene/59894:EYA3 ^@ http://purl.uniprot.org/uniprot/A0A803VW65|||http://purl.uniprot.org/uniprot/U3JEF6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/59894:TMEM184C ^@ http://purl.uniprot.org/uniprot/A0A803VF23|||http://purl.uniprot.org/uniprot/U3JSB9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RAB3GAP2 ^@ http://purl.uniprot.org/uniprot/U3KC95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP regulatory subunit family.|||Cytoplasm http://togogenome.org/gene/59894:NOP14 ^@ http://purl.uniprot.org/uniprot/U3K5B6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP14 family.|||Involved in nucleolar processing of pre-18S ribosomal RNA. Has a role in the nuclear export of 40S pre-ribosomal subunit to the cytoplasm.|||nucleolus http://togogenome.org/gene/59894:MED30 ^@ http://purl.uniprot.org/uniprot/U3JI03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 30 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/59894:TNFRSF19 ^@ http://purl.uniprot.org/uniprot/U3K217 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CHST1 ^@ http://purl.uniprot.org/uniprot/U3KIG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. Gal/GlcNAc/GalNAc subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101814202 ^@ http://purl.uniprot.org/uniprot/U3K6K6 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/59894:MRPL13 ^@ http://purl.uniprot.org/uniprot/A0A803WFM3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL13 family. http://togogenome.org/gene/59894:MRRF ^@ http://purl.uniprot.org/uniprot/A0A803VHA9 ^@ Function|||Similarity ^@ Belongs to the RRF family.|||Responsible for the release of ribosomes from messenger RNA at the termination of protein biosynthesis. May increase the efficiency of translation by recycling ribosomes from one round of translation to another. http://togogenome.org/gene/59894:CDKN3 ^@ http://purl.uniprot.org/uniprot/U3JMH5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/59894:FNIP1 ^@ http://purl.uniprot.org/uniprot/U3JE72 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FNIP family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:STOM ^@ http://purl.uniprot.org/uniprot/U3JGR8 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/59894:TYMS ^@ http://purl.uniprot.org/uniprot/U3JUQ8 ^@ Similarity ^@ Belongs to the thymidylate synthase family. http://togogenome.org/gene/59894:ACYP1 ^@ http://purl.uniprot.org/uniprot/U3JV14 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/59894:EPHB6 ^@ http://purl.uniprot.org/uniprot/U3JPE3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PPP1R9A ^@ http://purl.uniprot.org/uniprot/A0A803VN46|||http://purl.uniprot.org/uniprot/A0A803VXV0|||http://purl.uniprot.org/uniprot/A0A803WFE7|||http://purl.uniprot.org/uniprot/U3K6X2 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:PANK4 ^@ http://purl.uniprot.org/uniprot/U3K4K4 ^@ Similarity|||Subunit ^@ Belongs to the type II pantothenate kinase family.|||Homodimer. Interacts with PKM.|||In the N-terminal section; belongs to the type II pantothenate kinase family. http://togogenome.org/gene/59894:BAMBI ^@ http://purl.uniprot.org/uniprot/U3JXE5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BAMBI family.|||Membrane|||Negatively regulates TGF-beta signaling. http://togogenome.org/gene/59894:STK40 ^@ http://purl.uniprot.org/uniprot/U3JDL8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be a negative regulator of NF-kappa-B and p53-mediated gene transcription.|||Nucleus http://togogenome.org/gene/59894:PPM1F ^@ http://purl.uniprot.org/uniprot/U3JZR6 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59894:TUBB1 ^@ http://purl.uniprot.org/uniprot/A0A803VKP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:TSPAN12 ^@ http://purl.uniprot.org/uniprot/U3K5X0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:VWA9 ^@ http://purl.uniprot.org/uniprot/U3K655 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INTS14 family.|||Nucleus|||Probable component of the Integrator (INT) complex, a complex involved in the small nuclear RNAs (snRNA) U1 and U2 transcription and in their 3'-box-dependent processing. http://togogenome.org/gene/59894:GJD2 ^@ http://purl.uniprot.org/uniprot/A0A803WES4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:PCNA ^@ http://purl.uniprot.org/uniprot/U3JBU3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PCNA family.|||Nucleus|||This protein is an auxiliary protein of DNA polymerase delta and is involved in the control of eukaryotic DNA replication by increasing the polymerase's processibility during elongation of the leading strand. http://togogenome.org/gene/59894:LOC101808006 ^@ http://purl.uniprot.org/uniprot/U3KKH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:ASPHD2 ^@ http://purl.uniprot.org/uniprot/U3K1H5 ^@ Similarity ^@ Belongs to the aspartyl/asparaginyl beta-hydroxylase family. http://togogenome.org/gene/59894:LOC101810052 ^@ http://purl.uniprot.org/uniprot/U3JLM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59894:IREB2 ^@ http://purl.uniprot.org/uniprot/U3K7U4 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Cytoplasm|||RNA-binding protein that binds to iron-responsive elements (IRES), which are stem-loop structures found in the 5'-UTR of ferritin, and delta aminolevulinic acid synthase mRNAs, and in the 3'-UTR of transferrin receptor mRNA. Binding to the IRE element in ferritin results in the repression of its mRNA translation. Binding of the protein to the transferrin receptor mRNA inhibits the degradation of this otherwise rapidly degraded mRNA. http://togogenome.org/gene/59894:CRCP ^@ http://purl.uniprot.org/uniprot/A0A803VSC9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC9 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/59894:LHFPL3 ^@ http://purl.uniprot.org/uniprot/A0A803V2I4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ETS1 ^@ http://purl.uniprot.org/uniprot/U3JQV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SUV39H2 ^@ http://purl.uniprot.org/uniprot/U3JGU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily. Histone-lysine methyltransferase family. Suvar3-9 subfamily.|||Nucleus|||centromere http://togogenome.org/gene/59894:XPO1 ^@ http://purl.uniprot.org/uniprot/U3K8W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm http://togogenome.org/gene/59894:LOC101810353 ^@ http://purl.uniprot.org/uniprot/U3KEZ8 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:LOC101818143 ^@ http://purl.uniprot.org/uniprot/U3JSA5 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:C5H14orf166 ^@ http://purl.uniprot.org/uniprot/U3JGV8 ^@ Similarity ^@ Belongs to the RTRAF family. http://togogenome.org/gene/59894:PTPRE ^@ http://purl.uniprot.org/uniprot/A0A803VH18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 4 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:MTUS1 ^@ http://purl.uniprot.org/uniprot/U3K9T5|||http://purl.uniprot.org/uniprot/U3K9V1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MTUS1 family.|||Nucleus http://togogenome.org/gene/59894:HBP1 ^@ http://purl.uniprot.org/uniprot/U3K6P2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcriptional repressor that binds to the promoter region of target genes. Plays a role in the regulation of the cell cycle and of the Wnt pathway. Binds preferentially to the sequence 5'-TTCATTCATTCA-3'. Binding to the histone H1.0 promoter is enhanced by interaction with RB1. Disrupts the interaction between DNA and TCF4. http://togogenome.org/gene/59894:LOC101813268 ^@ http://purl.uniprot.org/uniprot/U3JFV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:VRTN ^@ http://purl.uniprot.org/uniprot/U3KLE1 ^@ Similarity ^@ Belongs to the vertnin family. http://togogenome.org/gene/59894:ECHDC2 ^@ http://purl.uniprot.org/uniprot/U3JSX2 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/59894:WISP1 ^@ http://purl.uniprot.org/uniprot/A0A803W3V5|||http://purl.uniprot.org/uniprot/U3JJ81 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:MMP23B ^@ http://purl.uniprot.org/uniprot/U3K432 ^@ Caution|||Similarity ^@ Belongs to the peptidase M10A family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LPCAT1 ^@ http://purl.uniprot.org/uniprot/U3JHJ1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:NR5A1 ^@ http://purl.uniprot.org/uniprot/U3JHG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/59894:ZW10 ^@ http://purl.uniprot.org/uniprot/U3JTY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZW10 family.|||kinetochore http://togogenome.org/gene/59894:CNR1 ^@ http://purl.uniprot.org/uniprot/A0A803V3N1|||http://purl.uniprot.org/uniprot/A0A803VM53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Mitochondrion outer membrane|||Presynapse|||Synapse|||axon http://togogenome.org/gene/59894:LOC101811535 ^@ http://purl.uniprot.org/uniprot/U3KKU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||High affinity receptor for urotensin-2 and urotensin-2B. The activity of this receptor is mediated by a G-protein that activate a phosphatidylinositol-calcium second messenger system.|||Membrane http://togogenome.org/gene/59894:GALNT11 ^@ http://purl.uniprot.org/uniprot/U3JWH8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:ATP8 ^@ http://purl.uniprot.org/uniprot/S0ARW1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATPase protein 8 family.|||F-type ATPases have 2 components, CF(1) - the catalytic core - and CF(0) - the membrane proton channel.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:LOC101821303 ^@ http://purl.uniprot.org/uniprot/U3K9Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/59894:ACVR2B ^@ http://purl.uniprot.org/uniprot/U3JWE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:PLCD4 ^@ http://purl.uniprot.org/uniprot/U3JNB4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum|||Nucleus http://togogenome.org/gene/59894:PAH ^@ http://purl.uniprot.org/uniprot/U3K3A9 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/59894:LPL ^@ http://purl.uniprot.org/uniprot/U3JR81 ^@ Caution|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Cell membrane|||Homodimer. Interacts with APOC2; the interaction activates LPL activity in the presence of lipids.|||Key enzyme in triglyceride metabolism. Catalyzes the hydrolysis of triglycerides from circulating chylomicrons and very low density lipoproteins (VLDL), and thereby plays an important role in lipid clearance from the blood stream, lipid utilization and storage. Mediates margination of triglyceride-rich lipoprotein particles in capillaries. Recruited to its site of action on the luminal surface of vascular endothelium by binding to GPIHBP1 and cell surface heparan sulfate proteoglycans.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted|||Tyrosine nitration after lipopolysaccharide (LPS) challenge down-regulates the lipase activity.|||extracellular matrix http://togogenome.org/gene/59894:GAD1 ^@ http://purl.uniprot.org/uniprot/U3JGZ0 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:PDLIM3 ^@ http://purl.uniprot.org/uniprot/A0A803VKR2|||http://purl.uniprot.org/uniprot/A0A803VT63|||http://purl.uniprot.org/uniprot/A0A803VXY5 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/59894:MYO1C ^@ http://purl.uniprot.org/uniprot/A0A803VW52|||http://purl.uniprot.org/uniprot/A0A803W7K4|||http://purl.uniprot.org/uniprot/U3JW13 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:TMEM43 ^@ http://purl.uniprot.org/uniprot/U3KDT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM43 family.|||Membrane http://togogenome.org/gene/59894:MRPL15 ^@ http://purl.uniprot.org/uniprot/U3K6K3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL15 family. http://togogenome.org/gene/59894:SEC24D ^@ http://purl.uniprot.org/uniprot/U3JDT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:IPO5 ^@ http://purl.uniprot.org/uniprot/U3JP88 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:LOC101815720 ^@ http://purl.uniprot.org/uniprot/U3JX53 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in neuronal plasticity and the proteolytic action may subserve structural reorganizations associated with learning and memory operations.|||Secreted http://togogenome.org/gene/59894:CCT3 ^@ http://purl.uniprot.org/uniprot/U3JIQ0|||http://purl.uniprot.org/uniprot/U3JIQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/59894:PKIB ^@ http://purl.uniprot.org/uniprot/A0A803W361 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/59894:MMRN1 ^@ http://purl.uniprot.org/uniprot/U3JU70 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GABRD ^@ http://purl.uniprot.org/uniprot/U3K4B8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:LOC101808957 ^@ http://purl.uniprot.org/uniprot/U3JPN3 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:RAN ^@ http://purl.uniprot.org/uniprot/A0A803W5F0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ran family.|||GTP-binding protein involved in nucleocytoplasmic transport. Required for the import of protein into the nucleus and also for RNA export. Involved in chromatin condensation and control of cell cycle.|||Nucleus http://togogenome.org/gene/59894:HTATSF1 ^@ http://purl.uniprot.org/uniprot/U3JM88 ^@ Similarity ^@ Belongs to the HTATSF1 family. http://togogenome.org/gene/59894:PLAGL2 ^@ http://purl.uniprot.org/uniprot/A0A803V838 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/59894:OSBPL10 ^@ http://purl.uniprot.org/uniprot/U3K3D4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:MAP2K3 ^@ http://purl.uniprot.org/uniprot/A0A803VFU8|||http://purl.uniprot.org/uniprot/U3KH91 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:LOC101816641 ^@ http://purl.uniprot.org/uniprot/A0A803W7S2 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/59894:SCAMP5 ^@ http://purl.uniprot.org/uniprot/A0A803W0P2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59894:LOC101810802 ^@ http://purl.uniprot.org/uniprot/U3KBA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59894:RPSA ^@ http://purl.uniprot.org/uniprot/U3KD08 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acylated. Acylation may be a prerequisite for conversion of the monomeric 37 kDa laminin receptor precursor (37LRP) to the mature dimeric 67 kDa laminin receptor (67LR), and may provide a mechanism for membrane association.|||Belongs to the universal ribosomal protein uS2 family.|||Cell membrane|||Cleaved by stromelysin-3 (ST3) at the cell surface. Cleavage by stromelysin-3 may be a mechanism to alter cell-extracellular matrix interactions.|||Cytoplasm|||Monomer (37LRP) and homodimer (67LR). Component of the small ribosomal subunit. Mature ribosomes consist of a small (40S) and a large (60S) subunit. The 40S subunit contains about 33 different proteins and 1 molecule of RNA (18S). The 60S subunit contains about 49 different proteins and 3 molecules of RNA (28S, 5.8S and 5S). Interacts with RPS21. Interacts with several laminins including at least LAMB1. Interacts with MDK.|||Nucleus|||Required for the assembly and/or stability of the 40S ribosomal subunit. Required for the processing of the 20S rRNA-precursor to mature 18S rRNA in a late step of the maturation of 40S ribosomal subunits. Also functions as a cell surface receptor for laminin. Plays a role in cell adhesion to the basement membrane and in the consequent activation of signaling transduction pathways. May play a role in cell fate determination and tissue morphogenesis.|||This protein appears to have acquired a second function as a laminin receptor specifically in the vertebrate lineage. http://togogenome.org/gene/59894:PPARA ^@ http://purl.uniprot.org/uniprot/U3JJL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/59894:PPP1R15B ^@ http://purl.uniprot.org/uniprot/U3JCE0 ^@ Similarity ^@ Belongs to the PPP1R15 family. http://togogenome.org/gene/59894:HUS1 ^@ http://purl.uniprot.org/uniprot/U3KFE5 ^@ Similarity ^@ Belongs to the HUS1 family. http://togogenome.org/gene/59894:INPP4B ^@ http://purl.uniprot.org/uniprot/U3JQV7 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/59894:PHKB ^@ http://purl.uniprot.org/uniprot/U3JBG6 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. http://togogenome.org/gene/59894:XRCC5 ^@ http://purl.uniprot.org/uniprot/U3JMY5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ku80 family.|||Nucleus|||Single-stranded DNA-dependent ATP-dependent helicase. http://togogenome.org/gene/59894:ACY1 ^@ http://purl.uniprot.org/uniprot/U3K2G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M20A family.|||Cytoplasm http://togogenome.org/gene/59894:CHMP1A ^@ http://purl.uniprot.org/uniprot/U3JKF3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF7 family.|||Cytoplasm|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:YWHAE ^@ http://purl.uniprot.org/uniprot/A0A803VGV7|||http://purl.uniprot.org/uniprot/A0A803VJK4 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:CUEDC2 ^@ http://purl.uniprot.org/uniprot/A0A803VNV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUEDC2 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:APOH ^@ http://purl.uniprot.org/uniprot/U3JIA9 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Binds to various kinds of negatively charged substances such as heparin, phospholipids, and dextran sulfate. May prevent activation of the intrinsic blood coagulation cascade by binding to phospholipids on the surface of damaged cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:FOXO6 ^@ http://purl.uniprot.org/uniprot/A0A803VAP2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LGI1 ^@ http://purl.uniprot.org/uniprot/U3JZF5 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:HRH1 ^@ http://purl.uniprot.org/uniprot/U3KIB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:HOXA10 ^@ http://purl.uniprot.org/uniprot/U3K473 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59894:LOC101817654 ^@ http://purl.uniprot.org/uniprot/U3JGP5 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59894:DNAAF1 ^@ http://purl.uniprot.org/uniprot/A0A803VEP4|||http://purl.uniprot.org/uniprot/U3JYX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNAAF1 family.|||cilium http://togogenome.org/gene/59894:EREG ^@ http://purl.uniprot.org/uniprot/U3K0D3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:HHAT ^@ http://purl.uniprot.org/uniprot/U3KDL1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:C2H8orf22 ^@ http://purl.uniprot.org/uniprot/U3JT93 ^@ Similarity ^@ Belongs to the PPDPF family. http://togogenome.org/gene/59894:PRKD3 ^@ http://purl.uniprot.org/uniprot/U3KB53 ^@ Activity Regulation|||Similarity|||Subcellular Location Annotation ^@ Activated by DAG and phorbol esters.|||Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. PKD subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:LOC101806955 ^@ http://purl.uniprot.org/uniprot/U3JZJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/59894:LOC101811458 ^@ http://purl.uniprot.org/uniprot/U3JMT9 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:VIPR2 ^@ http://purl.uniprot.org/uniprot/U3JWU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ORC6 ^@ http://purl.uniprot.org/uniprot/A0A803VMP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC6 family.|||Nucleus http://togogenome.org/gene/59894:LOC101809283 ^@ http://purl.uniprot.org/uniprot/U3JC52 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:ACTA1 ^@ http://purl.uniprot.org/uniprot/U3JL42 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:GNL2 ^@ http://purl.uniprot.org/uniprot/U3JDU1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class YlqF/YawG GTPase family. NOG2 subfamily.|||GTPase that associates with pre-60S ribosomal subunits in the nucleolus and is required for their nuclear export and maturation.|||nucleolus http://togogenome.org/gene/59894:PNMT ^@ http://purl.uniprot.org/uniprot/U3JCP7 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. NNMT/PNMT/TEMT family. http://togogenome.org/gene/59894:SLC7A11 ^@ http://purl.uniprot.org/uniprot/U3JQL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/59894:CSTA ^@ http://purl.uniprot.org/uniprot/A0A803VVE0 ^@ Similarity ^@ Belongs to the cystatin family. http://togogenome.org/gene/59894:FGD4 ^@ http://purl.uniprot.org/uniprot/A0A803V3J1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:POT1 ^@ http://purl.uniprot.org/uniprot/A0A803WAV6|||http://purl.uniprot.org/uniprot/U3K5H3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the telombin family.|||Nucleus|||telomere http://togogenome.org/gene/59894:NDUFV2 ^@ http://purl.uniprot.org/uniprot/U3JV48 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the complex I 24 kDa subunit family.|||Binds 1 [2Fe-2S] cluster.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. http://togogenome.org/gene/59894:PYCR1 ^@ http://purl.uniprot.org/uniprot/U3KBI1 ^@ Similarity ^@ Belongs to the pyrroline-5-carboxylate reductase family. http://togogenome.org/gene/59894:CHRM5 ^@ http://purl.uniprot.org/uniprot/U3KL95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/59894:PMEPA1 ^@ http://purl.uniprot.org/uniprot/A0A803VN90|||http://purl.uniprot.org/uniprot/A0A803W5D4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:PRICKLE2 ^@ http://purl.uniprot.org/uniprot/U3KFN9 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/59894:COX1 ^@ http://purl.uniprot.org/uniprot/S0ASK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heme-copper respiratory oxidase family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SPCS1 ^@ http://purl.uniprot.org/uniprot/U3K2V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPCS1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LOC101822186 ^@ http://purl.uniprot.org/uniprot/U3K9E5 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. LDH family. http://togogenome.org/gene/59894:CPB2 ^@ http://purl.uniprot.org/uniprot/U3K0J5 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:C1H11orf54 ^@ http://purl.uniprot.org/uniprot/U3JBZ7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Exhibits ester hydrolase activity on the substrate p-nitrophenyl acetate.|||Monomer.|||Nucleus http://togogenome.org/gene/59894:AGXT2 ^@ http://purl.uniprot.org/uniprot/U3JHD1 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59894:MCM6 ^@ http://purl.uniprot.org/uniprot/U3KH43 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/59894:ZNRF3 ^@ http://purl.uniprot.org/uniprot/U3K0U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZNRF3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CDH8 ^@ http://purl.uniprot.org/uniprot/U3JC08 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PPP2R3C ^@ http://purl.uniprot.org/uniprot/U3JU09 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:DFNB59 ^@ http://purl.uniprot.org/uniprot/U3JL98 ^@ Similarity ^@ Belongs to the gasdermin family. http://togogenome.org/gene/59894:SLC1A2 ^@ http://purl.uniprot.org/uniprot/U3KDC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59894:ARSI ^@ http://purl.uniprot.org/uniprot/U3JZX8 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:MCCC2 ^@ http://purl.uniprot.org/uniprot/U3KCS1 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/59894:LOC101815193 ^@ http://purl.uniprot.org/uniprot/U3JTA3 ^@ Similarity ^@ Belongs to the cytochrome c oxidase subunit 6c family. http://togogenome.org/gene/59894:PRKAB2 ^@ http://purl.uniprot.org/uniprot/U3JME5 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/59894:CRABP1 ^@ http://purl.uniprot.org/uniprot/U3K7U2 ^@ Function|||Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytosolic CRABPs may regulate the access of retinoic acid to the nuclear retinoic acid receptors. http://togogenome.org/gene/59894:ATP8B2 ^@ http://purl.uniprot.org/uniprot/U3JEN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59894:SNX5 ^@ http://purl.uniprot.org/uniprot/U3JYQ5 ^@ Function|||Similarity ^@ Belongs to the sorting nexin family.|||Involved in several stages of intracellular trafficking. http://togogenome.org/gene/59894:LOC101809344 ^@ http://purl.uniprot.org/uniprot/U3JKH2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:RIMBP2 ^@ http://purl.uniprot.org/uniprot/U3K4I4 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/59894:ZIC1 ^@ http://purl.uniprot.org/uniprot/U3JX97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/59894:EXOC2 ^@ http://purl.uniprot.org/uniprot/A0A803W719|||http://purl.uniprot.org/uniprot/U3KF33 ^@ Function|||Similarity|||Subunit ^@ Belongs to the SEC5 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane.|||Component of the exocyst complex. http://togogenome.org/gene/59894:CPT2 ^@ http://purl.uniprot.org/uniprot/U3JT67 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/59894:TOMM5 ^@ http://purl.uniprot.org/uniprot/U3KEM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Tom5 family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:VIPAS39 ^@ http://purl.uniprot.org/uniprot/U3KDY1 ^@ Subcellular Location Annotation ^@ Endosome|||Late endosome|||Vesicle http://togogenome.org/gene/59894:TPRA1 ^@ http://purl.uniprot.org/uniprot/U3JZI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0359 family.|||Membrane http://togogenome.org/gene/59894:RFC5 ^@ http://purl.uniprot.org/uniprot/A0A803VKK7 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/59894:CDK14 ^@ http://purl.uniprot.org/uniprot/A0A803V4P1|||http://purl.uniprot.org/uniprot/A0A803VBA6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:PHLDA1 ^@ http://purl.uniprot.org/uniprot/U3KK06 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:FAM214A ^@ http://purl.uniprot.org/uniprot/U3KBQ8 ^@ Similarity ^@ Belongs to the FAM214 family. http://togogenome.org/gene/59894:SF3A3 ^@ http://purl.uniprot.org/uniprot/U3JE50 ^@ Similarity ^@ Belongs to the SF3A3 family. http://togogenome.org/gene/59894:CLDN19 ^@ http://purl.uniprot.org/uniprot/U3K6W9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:GRM2 ^@ http://purl.uniprot.org/uniprot/U3K297 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LUC7L ^@ http://purl.uniprot.org/uniprot/U3JNG8 ^@ Similarity ^@ Belongs to the Luc7 family. http://togogenome.org/gene/59894:KIF4A ^@ http://purl.uniprot.org/uniprot/A0A803W5C2|||http://purl.uniprot.org/uniprot/U3JNC6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:TFRC ^@ http://purl.uniprot.org/uniprot/U3JYE7 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system. Acts as a lipid sensor that regulates mitochondrial fusion by regulating activation of the JNK pathway.|||Homodimer; disulfide-linked.|||Melanosome|||Membrane|||Stearoylated. http://togogenome.org/gene/59894:VPS26A ^@ http://purl.uniprot.org/uniprot/U3KF40 ^@ Similarity ^@ Belongs to the VPS26 family. http://togogenome.org/gene/59894:STRN3 ^@ http://purl.uniprot.org/uniprot/A0A803V724|||http://purl.uniprot.org/uniprot/A0A803VXA1|||http://purl.uniprot.org/uniprot/A0A803W082|||http://purl.uniprot.org/uniprot/U3JTH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat striatin family.|||Membrane http://togogenome.org/gene/59894:MRPL44 ^@ http://purl.uniprot.org/uniprot/U3JWS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ribonuclease III family. Mitochondrion-specific ribosomal protein mL44 subfamily.|||Mitochondrion http://togogenome.org/gene/59894:LOC101817171 ^@ http://purl.uniprot.org/uniprot/A0A803VIJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:MMP16 ^@ http://purl.uniprot.org/uniprot/U3JRD6 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/59894:SLC24A2 ^@ http://purl.uniprot.org/uniprot/A0A803V6L7|||http://purl.uniprot.org/uniprot/U3JKA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/59894:GRIA1 ^@ http://purl.uniprot.org/uniprot/A0A803W9W6|||http://purl.uniprot.org/uniprot/U3K0R7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:NDUFB1 ^@ http://purl.uniprot.org/uniprot/U3JI93 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB1 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:CIRBP ^@ http://purl.uniprot.org/uniprot/U3KHV9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||nucleoplasm http://togogenome.org/gene/59894:C1GALT1 ^@ http://purl.uniprot.org/uniprot/A0A803VL27 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family. Beta3-Gal-T subfamily.|||Glycosyltransferase that generates the core 1 O-glycan Gal-beta1-3GalNAc-alpha1-Ser/Thr (T antigen), which is a precursor for many extended O-glycans in glycoproteins.|||Membrane http://togogenome.org/gene/59894:ESRP1 ^@ http://purl.uniprot.org/uniprot/U3JSH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESRP family.|||Nucleus http://togogenome.org/gene/59894:SORD ^@ http://purl.uniprot.org/uniprot/U3K5G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the zinc-containing alcohol dehydrogenase family.|||Mitochondrion membrane|||flagellum http://togogenome.org/gene/59894:CUL4B ^@ http://purl.uniprot.org/uniprot/U3JFP1 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59894:ATP6V0A1 ^@ http://purl.uniprot.org/uniprot/U3JD46 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/59894:DCLK3 ^@ http://purl.uniprot.org/uniprot/U3JJP2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/59894:SNRPA1 ^@ http://purl.uniprot.org/uniprot/U3K6I7 ^@ Similarity ^@ Belongs to the U2 small nuclear ribonucleoprotein A family. http://togogenome.org/gene/59894:DLGAP5 ^@ http://purl.uniprot.org/uniprot/A0A803V1Q5 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/59894:KCTD20 ^@ http://purl.uniprot.org/uniprot/A0A803V290|||http://purl.uniprot.org/uniprot/A0A803VY24|||http://purl.uniprot.org/uniprot/U3JKM6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ATP1B4 ^@ http://purl.uniprot.org/uniprot/U3JFQ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/59894:CLIC4 ^@ http://purl.uniprot.org/uniprot/U3JCI0 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/59894:HEBP2 ^@ http://purl.uniprot.org/uniprot/U3JK01 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/59894:COX2 ^@ http://purl.uniprot.org/uniprot/S0AT20 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 2 family.|||Binds a copper A center.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:LOC101814338 ^@ http://purl.uniprot.org/uniprot/U3K4H5 ^@ Subcellular Location Annotation ^@ centrosome|||perinuclear region http://togogenome.org/gene/59894:FIGNL1 ^@ http://purl.uniprot.org/uniprot/U3KKF8 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59894:WASF3 ^@ http://purl.uniprot.org/uniprot/A0A803W718|||http://purl.uniprot.org/uniprot/U3K1X2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCAR/WAVE family.|||Binds actin and the Arp2/3 complex.|||Downstream effector molecule involved in the transmission of signals from tyrosine kinase receptors and small GTPases to the actin cytoskeleton. Promotes formation of actin filaments. Part of the WAVE complex that regulates lamellipodia formation. The WAVE complex regulates actin filament reorganization via its interaction with the Arp2/3 complex.|||cytoskeleton http://togogenome.org/gene/59894:MTFR2 ^@ http://purl.uniprot.org/uniprot/U3KEP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/59894:CPLX3 ^@ http://purl.uniprot.org/uniprot/U3K8Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59894:RGMA ^@ http://purl.uniprot.org/uniprot/U3K707 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the repulsive guidance molecule (RGM) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SHQ1 ^@ http://purl.uniprot.org/uniprot/U3KG57 ^@ Similarity ^@ Belongs to the SHQ1 family. http://togogenome.org/gene/59894:RAB4A ^@ http://purl.uniprot.org/uniprot/U3JL07 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. http://togogenome.org/gene/59894:FURIN ^@ http://purl.uniprot.org/uniprot/U3K9L3 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/59894:PKD2L1 ^@ http://purl.uniprot.org/uniprot/U3JY36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/59894:STXBP5 ^@ http://purl.uniprot.org/uniprot/A0A803V7C6|||http://purl.uniprot.org/uniprot/A0A803VTI5|||http://purl.uniprot.org/uniprot/U3KF68 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:LOC101810563 ^@ http://purl.uniprot.org/uniprot/U3KIQ1 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/59894:CHPT1 ^@ http://purl.uniprot.org/uniprot/U3K358 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/59894:GDF5 ^@ http://purl.uniprot.org/uniprot/U3KDA2 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/59894:SMAD5 ^@ http://purl.uniprot.org/uniprot/U3K056 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:IDS ^@ http://purl.uniprot.org/uniprot/U3KC79 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:ACER2 ^@ http://purl.uniprot.org/uniprot/A0A803WCK4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LETM1 ^@ http://purl.uniprot.org/uniprot/U3K5S6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LETM1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:EHD3 ^@ http://purl.uniprot.org/uniprot/U3KAA3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Endosome membrane|||Membrane|||Recycling endosome membrane|||cilium membrane http://togogenome.org/gene/59894:DUPD1 ^@ http://purl.uniprot.org/uniprot/A0A803VDK1 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/59894:LAMC1 ^@ http://purl.uniprot.org/uniprot/U3JK20 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/59894:POLR3K ^@ http://purl.uniprot.org/uniprot/U3JN74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal rpoM/eukaryotic RPA12/RPB9/RPC11 RNA polymerase family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||nucleolus http://togogenome.org/gene/59894:S100B ^@ http://purl.uniprot.org/uniprot/A0A803V4D0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the S-100 family.|||Cytoplasm|||Nucleus|||Weakly binds calcium but binds zinc very tightly-distinct binding sites with different affinities exist for both ions on each monomer. Physiological concentrations of potassium ion antagonize the binding of both divalent cations, especially affecting high-affinity calcium-binding sites. Binds to and initiates the activation of STK38 by releasing autoinhibitory intramolecular interactions within the kinase. Interaction with AGER after myocardial infarction may play a role in myocyte apoptosis by activating ERK1/2 and p53/TP53 signaling. Could assist ATAD3A cytoplasmic processing, preventing aggregation and favoring mitochondrial localization. May mediate calcium-dependent regulation on many physiological processes by interacting with other proteins, such as TPR-containing proteins, and modulating their activity. http://togogenome.org/gene/59894:CEP19 ^@ http://purl.uniprot.org/uniprot/A0A803VNU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP19 family.|||centriole|||cilium basal body|||spindle pole http://togogenome.org/gene/59894:EFNB2 ^@ http://purl.uniprot.org/uniprot/U3JNP1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ephrin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101819037 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:CSNK1D ^@ http://purl.uniprot.org/uniprot/A0A803VR45|||http://purl.uniprot.org/uniprot/A0A803VUM9|||http://purl.uniprot.org/uniprot/U3KAW9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:LOC101817954 ^@ http://purl.uniprot.org/uniprot/A0A803VLE0 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:EMC3 ^@ http://purl.uniprot.org/uniprot/U3K263 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the EMC3 family.|||Component of the ER membrane protein complex (EMC).|||Membrane http://togogenome.org/gene/59894:HEATR5B ^@ http://purl.uniprot.org/uniprot/U3KBI2 ^@ Similarity ^@ Belongs to the HEATR5 family. http://togogenome.org/gene/59894:MTFP1 ^@ http://purl.uniprot.org/uniprot/U3JWR1 ^@ Similarity ^@ Belongs to the MTFP1 family. http://togogenome.org/gene/59894:LCOR ^@ http://purl.uniprot.org/uniprot/A0A803VCZ1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DCLK1 ^@ http://purl.uniprot.org/uniprot/A0A803V2R1|||http://purl.uniprot.org/uniprot/U3K0X9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/59894:HBEGF ^@ http://purl.uniprot.org/uniprot/U3K439 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101811710 ^@ http://purl.uniprot.org/uniprot/U3KE09 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CAMSAP2 ^@ http://purl.uniprot.org/uniprot/A0A803W509|||http://purl.uniprot.org/uniprot/U3JJ58 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/59894:ADD3 ^@ http://purl.uniprot.org/uniprot/A0A803VBB6|||http://purl.uniprot.org/uniprot/U3JI08|||http://purl.uniprot.org/uniprot/U3JI10 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/59894:CDR2 ^@ http://purl.uniprot.org/uniprot/U3KHV4 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/59894:SLC26A5 ^@ http://purl.uniprot.org/uniprot/U3K734 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/59894:TMEM65 ^@ http://purl.uniprot.org/uniprot/A0A803V031 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ENKD1 ^@ http://purl.uniprot.org/uniprot/U3JWW1 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/59894:LOC101821726 ^@ http://purl.uniprot.org/uniprot/U3JUU4 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:SLC44A3 ^@ http://purl.uniprot.org/uniprot/U3JI48 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CTL (choline transporter-like) family.|||Cell membrane|||Choline transporter.|||Membrane http://togogenome.org/gene/59894:PIWIL1 ^@ http://purl.uniprot.org/uniprot/U3K4E1 ^@ Similarity ^@ Belongs to the argonaute family. http://togogenome.org/gene/59894:OLA1 ^@ http://purl.uniprot.org/uniprot/U3JK06 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. YchF/OLA1 subfamily.|||Cytoplasm|||Hydrolyzes ATP, and can also hydrolyze GTP with lower efficiency. Has lower affinity for GTP.|||Monomer.|||Nucleus|||nucleolus http://togogenome.org/gene/59894:MSH6 ^@ http://purl.uniprot.org/uniprot/U3K9A9 ^@ Function|||Similarity ^@ Belongs to the DNA mismatch repair MutS family.|||Component of the post-replicative DNA mismatch repair system (MMR). http://togogenome.org/gene/59894:TRPV1 ^@ http://purl.uniprot.org/uniprot/U3JTZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. TrpV subfamily. TRPV1 sub-subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendritic spine membrane http://togogenome.org/gene/59894:P2RY8 ^@ http://purl.uniprot.org/uniprot/U3KKT0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:EGFR ^@ http://purl.uniprot.org/uniprot/U3JQX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:CTSB ^@ http://purl.uniprot.org/uniprot/U3JIJ7 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59894:SCNN1A ^@ http://purl.uniprot.org/uniprot/U3JQM7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RPL8 ^@ http://purl.uniprot.org/uniprot/U3JFP0 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL2 family. http://togogenome.org/gene/59894:HYAL3 ^@ http://purl.uniprot.org/uniprot/A0A803WEL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Early endosome|||Endoplasmic reticulum|||Endosome|||Membrane|||acrosome http://togogenome.org/gene/59894:DPYD ^@ http://purl.uniprot.org/uniprot/A0A803WCL9 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the dihydropyrimidine dehydrogenase family.|||Binds 4 [4Fe-4S] clusters. Contains approximately 16 iron atoms per subunit.|||Involved in pyrimidine base degradation. Catalyzes the reduction of uracil and thymine. http://togogenome.org/gene/59894:CUL4A ^@ http://purl.uniprot.org/uniprot/U3JKQ4 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59894:LIPG ^@ http://purl.uniprot.org/uniprot/U3K2V9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:HS2ST1 ^@ http://purl.uniprot.org/uniprot/A0A803VGD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 3 family.|||Membrane http://togogenome.org/gene/59894:LBR ^@ http://purl.uniprot.org/uniprot/U3KB62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/59894:CLRN1 ^@ http://purl.uniprot.org/uniprot/U3JRH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/59894:HEPH ^@ http://purl.uniprot.org/uniprot/U3JNS0 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/59894:BMPR1A ^@ http://purl.uniprot.org/uniprot/U3JW25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:KDELR3 ^@ http://purl.uniprot.org/uniprot/U3KDM2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERD2 family.|||COPI-coated vesicle membrane|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:GPR65 ^@ http://purl.uniprot.org/uniprot/U3KJB9 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:CLGN ^@ http://purl.uniprot.org/uniprot/A0A803V255|||http://purl.uniprot.org/uniprot/U3JQQ1 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/59894:IQSEC3 ^@ http://purl.uniprot.org/uniprot/U3JMI7 ^@ Similarity ^@ Belongs to the BRAG family. http://togogenome.org/gene/59894:STEAP4 ^@ http://purl.uniprot.org/uniprot/U3JZM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:FYN ^@ http://purl.uniprot.org/uniprot/A0A803W6D8|||http://purl.uniprot.org/uniprot/A0A803WAX9|||http://purl.uniprot.org/uniprot/U3K8R9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:RFC4 ^@ http://purl.uniprot.org/uniprot/U3K0M6 ^@ Similarity ^@ Belongs to the activator 1 small subunits family. http://togogenome.org/gene/59894:IL1R1 ^@ http://purl.uniprot.org/uniprot/U3JM67 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59894:TET2 ^@ http://purl.uniprot.org/uniprot/U3K0N1 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/59894:SULF2 ^@ http://purl.uniprot.org/uniprot/A0A803V5V4|||http://purl.uniprot.org/uniprot/A0A803VGN4|||http://purl.uniprot.org/uniprot/U3KEL7 ^@ Cofactor|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase family.|||Binds 1 Ca(2+) ion per subunit.|||Cell surface|||Endoplasmic reticulum|||Golgi stack|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:CEP44 ^@ http://purl.uniprot.org/uniprot/U3KAE3 ^@ Subcellular Location Annotation ^@ Midbody|||centriole|||spindle pole http://togogenome.org/gene/59894:PIK3R1 ^@ http://purl.uniprot.org/uniprot/A0A803V3M1|||http://purl.uniprot.org/uniprot/A0A803VZJ0|||http://purl.uniprot.org/uniprot/U3K5G8 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/59894:REEP3 ^@ http://purl.uniprot.org/uniprot/U3KFP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/59894:ATP6V0A2 ^@ http://purl.uniprot.org/uniprot/U3K3W8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/59894:ATP2C2 ^@ http://purl.uniprot.org/uniprot/U3JW43 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:WAPL ^@ http://purl.uniprot.org/uniprot/U3JVW9 ^@ Similarity ^@ Belongs to the WAPL family. http://togogenome.org/gene/59894:MAP7 ^@ http://purl.uniprot.org/uniprot/A0A803VAC5|||http://purl.uniprot.org/uniprot/U3KEN3 ^@ Similarity ^@ Belongs to the MAP7 family. http://togogenome.org/gene/59894:LOC101808769 ^@ http://purl.uniprot.org/uniprot/U3KJB0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:GJA8 ^@ http://purl.uniprot.org/uniprot/U3KJX7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:ST8SIA4 ^@ http://purl.uniprot.org/uniprot/U3JJX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:SLC46A3 ^@ http://purl.uniprot.org/uniprot/U3K1J8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MAEA ^@ http://purl.uniprot.org/uniprot/U3K621 ^@ Subcellular Location Annotation ^@ Nucleus matrix http://togogenome.org/gene/59894:FTH1 ^@ http://purl.uniprot.org/uniprot/U3JPF0 ^@ Function|||Similarity ^@ Belongs to the ferritin family.|||Stores iron in a soluble, non-toxic, readily available form. Important for iron homeostasis. Iron is taken up in the ferrous form and deposited as ferric hydroxides after oxidation. http://togogenome.org/gene/59894:SGMS2 ^@ http://purl.uniprot.org/uniprot/U3KCW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/59894:RBBP4 ^@ http://purl.uniprot.org/uniprot/U3JCW4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:NDUFV1 ^@ http://purl.uniprot.org/uniprot/U3JF28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 51 kDa subunit family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:EPHA7 ^@ http://purl.uniprot.org/uniprot/U3JKV4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SCG2 ^@ http://purl.uniprot.org/uniprot/U3JW98 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/59894:LOC101813011 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:OGN ^@ http://purl.uniprot.org/uniprot/U3K349 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||Induces bone formation in conjunction with TGF-beta-1 or TGF-beta-2.|||extracellular matrix http://togogenome.org/gene/59894:LOC101815725 ^@ http://purl.uniprot.org/uniprot/U3JZ37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline phosphatase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:AMD1 ^@ http://purl.uniprot.org/uniprot/U3K8A8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic AdoMetDC family.|||Binds 1 pyruvoyl group covalently per subunit.|||Essential for biosynthesis of the polyamines spermidine and spermine. Promotes maintenance and self-renewal of embryonic stem cells, by maintaining spermine levels. http://togogenome.org/gene/59894:ADSL ^@ http://purl.uniprot.org/uniprot/U3KCG7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the lyase 1 family. Adenylosuccinate lyase subfamily.|||Catalyzes two non-sequential steps in de novo AMP synthesis: converts (S)-2-(5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamido)succinate (SAICAR) to fumarate plus 5-amino-1-(5-phospho-D-ribosyl)imidazole-4-carboxamide, and thereby also contributes to de novo IMP synthesis, and converts succinyladenosine monophosphate (SAMP) to AMP and fumarate.|||Homotetramer. Residues from neighboring subunits contribute catalytic and substrate-binding residues to each active site. http://togogenome.org/gene/59894:LOC101818444 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:HSP90AA1 ^@ http://purl.uniprot.org/uniprot/U3JJA1 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/59894:BMS1 ^@ http://purl.uniprot.org/uniprot/U3JWM7 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:ARPP19 ^@ http://purl.uniprot.org/uniprot/U3KBM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/59894:TRAF1 ^@ http://purl.uniprot.org/uniprot/U3JGH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/59894:RPL27 ^@ http://purl.uniprot.org/uniprot/U3JDE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic ribosomal protein eL27 family.|||Endoplasmic reticulum|||Rough endoplasmic reticulum http://togogenome.org/gene/59894:SYNDIG1L ^@ http://purl.uniprot.org/uniprot/U3JUV2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:COMTD1 ^@ http://purl.uniprot.org/uniprot/U3JWU1 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/59894:KIF21A ^@ http://purl.uniprot.org/uniprot/A0A803VKH5|||http://purl.uniprot.org/uniprot/A0A803VS61|||http://purl.uniprot.org/uniprot/A0A803W1V0|||http://purl.uniprot.org/uniprot/A0A803W388|||http://purl.uniprot.org/uniprot/U3K647 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||cytoskeleton http://togogenome.org/gene/59894:RALY ^@ http://purl.uniprot.org/uniprot/A0A803VU39|||http://purl.uniprot.org/uniprot/A0A803WGU9 ^@ Similarity ^@ Belongs to the RRM HNRPC family. RALY subfamily. http://togogenome.org/gene/59894:LOC101815012 ^@ http://purl.uniprot.org/uniprot/A0A803V8I0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:METTL4 ^@ http://purl.uniprot.org/uniprot/U3JUS2 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/59894:SLC7A2 ^@ http://purl.uniprot.org/uniprot/A0A803W985|||http://purl.uniprot.org/uniprot/U3K9Z0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:USP18 ^@ http://purl.uniprot.org/uniprot/U3K4Q5 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:SFR1 ^@ http://purl.uniprot.org/uniprot/U3K2E9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SFR1/MEI5 family.|||Nucleus http://togogenome.org/gene/59894:CLIC5 ^@ http://purl.uniprot.org/uniprot/U3JFK3 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel CLIC family.|||Cytoplasm|||Members of this family may change from a globular, soluble state to a state where the N-terminal domain is inserted into the membrane and functions as chloride channel. A conformation change of the N-terminal domain is thought to expose hydrophobic surfaces that trigger membrane insertion.|||Membrane http://togogenome.org/gene/59894:HOXD12 ^@ http://purl.uniprot.org/uniprot/U3JKE7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:YWHAH ^@ http://purl.uniprot.org/uniprot/U3JY62 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:GCK ^@ http://purl.uniprot.org/uniprot/U3JBB1 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/59894:BICD2 ^@ http://purl.uniprot.org/uniprot/A0A803VM33 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/59894:MYO6 ^@ http://purl.uniprot.org/uniprot/U3JIX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family.|||clathrin-coated pit|||clathrin-coated vesicle|||filopodium|||microvillus http://togogenome.org/gene/59894:LOC101806016 ^@ http://purl.uniprot.org/uniprot/U3JCA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||Secreted http://togogenome.org/gene/59894:PIGX ^@ http://purl.uniprot.org/uniprot/U3JKC8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGX family.|||Endoplasmic reticulum membrane|||Essential component of glycosylphosphatidylinositol-mannosyltransferase 1 which transfers the first of the 4 mannoses in the GPI-anchor precursors during GPI-anchor biosynthesis. http://togogenome.org/gene/59894:RBBP8 ^@ http://purl.uniprot.org/uniprot/U3JUG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COM1/SAE2/CtIP family.|||Nucleus http://togogenome.org/gene/59894:LOC101808823 ^@ http://purl.uniprot.org/uniprot/U3KJP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. A (Shaker) (TC 1.A.1.2) subfamily. Kv1.2/KCNA2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:EXOSC9 ^@ http://purl.uniprot.org/uniprot/U3K0W5 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:PRDM10 ^@ http://purl.uniprot.org/uniprot/A0A803VEX8|||http://purl.uniprot.org/uniprot/U3JQN2 ^@ Function|||Subcellular Location Annotation ^@ May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/59894:PLPPR4 ^@ http://purl.uniprot.org/uniprot/A0A803VNJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/59894:NLK ^@ http://purl.uniprot.org/uniprot/U3JQI6 ^@ Activity Regulation|||Similarity ^@ Activated by threonine and tyrosine phosphorylation.|||Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. MAP kinase subfamily. http://togogenome.org/gene/59894:PPT1 ^@ http://purl.uniprot.org/uniprot/U3JCN1 ^@ Similarity ^@ Belongs to the palmitoyl-protein thioesterase family. http://togogenome.org/gene/59894:USP3 ^@ http://purl.uniprot.org/uniprot/A0A803WDG1|||http://purl.uniprot.org/uniprot/U3K7M3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:ERN2 ^@ http://purl.uniprot.org/uniprot/U3JMG7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:KCNJ11 ^@ http://purl.uniprot.org/uniprot/U3KJL7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family. KCNJ11 subfamily.|||Membrane http://togogenome.org/gene/59894:PUS3 ^@ http://purl.uniprot.org/uniprot/U3JRG3 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/59894:TSEN2 ^@ http://purl.uniprot.org/uniprot/U3JB59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tRNA-intron endonuclease family.|||Constitutes one of the two catalytic subunit of the tRNA-splicing endonuclease complex, a complex responsible for identification and cleavage of the splice sites in pre-tRNA. It cleaves pre-tRNA at the 5'- and 3'-splice sites to release the intron. The products are an intron and two tRNA half-molecules bearing 2',3'-cyclic phosphate and 5'-OH termini. There are no conserved sequences at the splice sites, but the intron is invariably located at the same site in the gene, placing the splice sites an invariant distance from the constant structural features of the tRNA body.|||Nucleus http://togogenome.org/gene/59894:ESR2 ^@ http://purl.uniprot.org/uniprot/U3JKT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/59894:HSPA8 ^@ http://purl.uniprot.org/uniprot/U3JTG3 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/59894:SLC12A3 ^@ http://purl.uniprot.org/uniprot/U3JYG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC12A transporter family.|||Membrane http://togogenome.org/gene/59894:RXFP1 ^@ http://purl.uniprot.org/uniprot/U3JK81 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101816351 ^@ http://purl.uniprot.org/uniprot/U3KD10 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:OCSTAMP ^@ http://purl.uniprot.org/uniprot/A0A803VJ74 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PSMA7 ^@ http://purl.uniprot.org/uniprot/U3K7R2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59894:SPHKAP ^@ http://purl.uniprot.org/uniprot/A0A803W6T5|||http://purl.uniprot.org/uniprot/U3JWU5 ^@ Similarity ^@ Belongs to the AKAP110 family. http://togogenome.org/gene/59894:COPG1 ^@ http://purl.uniprot.org/uniprot/U3JZX2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59894:LOC101819291 ^@ http://purl.uniprot.org/uniprot/U3JVM6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SUGCT ^@ http://purl.uniprot.org/uniprot/A0A803VLZ0|||http://purl.uniprot.org/uniprot/U3JRD2 ^@ Similarity ^@ Belongs to the CoA-transferase III family. http://togogenome.org/gene/59894:RABEP1 ^@ http://purl.uniprot.org/uniprot/U3K587 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rabaptin family.|||Cytoplasm|||Early endosome|||Endosome http://togogenome.org/gene/59894:RNFT1 ^@ http://purl.uniprot.org/uniprot/A0A803VEG7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:INTS7 ^@ http://purl.uniprot.org/uniprot/U3KD91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 7 family.|||Nucleus http://togogenome.org/gene/59894:UFD1L ^@ http://purl.uniprot.org/uniprot/U3JZX6 ^@ Similarity ^@ Belongs to the UFD1 family. http://togogenome.org/gene/59894:VOPP1 ^@ http://purl.uniprot.org/uniprot/A0A803V5X9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VOPP1/ECOP family.|||Cytoplasmic vesicle membrane|||Membrane http://togogenome.org/gene/59894:IPO11 ^@ http://purl.uniprot.org/uniprot/U3K964 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:GJA4 ^@ http://purl.uniprot.org/uniprot/U3KIN1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:LOC101814429 ^@ http://purl.uniprot.org/uniprot/U3JNP7 ^@ Similarity ^@ Belongs to the DNase I family. http://togogenome.org/gene/59894:GRHL3 ^@ http://purl.uniprot.org/uniprot/U3JCK5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ATP2C1 ^@ http://purl.uniprot.org/uniprot/A0A803W7M2|||http://purl.uniprot.org/uniprot/U3KDJ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Golgi stack membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Monomer. Homodimer.|||trans-Golgi network membrane http://togogenome.org/gene/59894:PWP2 ^@ http://purl.uniprot.org/uniprot/U3KCT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat PWP2 family.|||nucleolus http://togogenome.org/gene/59894:TMEM39B ^@ http://purl.uniprot.org/uniprot/U3JD06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM39 family.|||Membrane http://togogenome.org/gene/59894:SNX14 ^@ http://purl.uniprot.org/uniprot/A0A803VYU5|||http://purl.uniprot.org/uniprot/U3JJQ4|||http://purl.uniprot.org/uniprot/U3JJQ8 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/59894:COX3 ^@ http://purl.uniprot.org/uniprot/S0AU80 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase subunit 3 family.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Electrons originating from reduced cytochrome c in the intermembrane space (IMS) are transferred via the dinuclear copper A center (CU(A)) of subunit 2 and heme A of subunit 1 to the active site in subunit 1, a binuclear center (BNC) formed by heme A3 and copper B (CU(B)). The BNC reduces molecular oxygen to 2 water molecules using 4 electrons from cytochrome c in the IMS and 4 protons from the mitochondrial matrix.|||Membrane http://togogenome.org/gene/59894:ABCB6 ^@ http://purl.uniprot.org/uniprot/U3JNL9 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ABC transporter superfamily. ABCB family. Heavy Metal importer (TC 3.A.1.210) subfamily.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Homodimer.|||Late endosome membrane|||Lysosome membrane|||Melanosome membrane|||Membrane|||Mitochondrion outer membrane|||extracellular exosome|||multivesicular body membrane http://togogenome.org/gene/59894:PDZK1IP1 ^@ http://purl.uniprot.org/uniprot/U3K3V4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:METAP2 ^@ http://purl.uniprot.org/uniprot/A0A803W9S1 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase eukaryotic type 2 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Binds EIF2S1 at low magnesium concentrations. Interacts strongly with the eIF-2 gamma-subunit EIF2S3.|||Contains approximately 12 O-linked N-acetylglucosamine (GlcNAc) residues. O-glycosylation is required for EIF2S1 binding.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val).|||Cytoplasm|||Protects eukaryotic initiation factor EIF2S1 from translation-inhibiting phosphorylation by inhibitory kinases such as EIF2AK2/PKR and EIF2AK1/HCR. Plays a critical role in the regulation of protein synthesis. http://togogenome.org/gene/59894:SYT2 ^@ http://purl.uniprot.org/uniprot/A0A803W3A1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:INSR ^@ http://purl.uniprot.org/uniprot/U3KHF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/59894:FAM102B ^@ http://purl.uniprot.org/uniprot/U3JJ21 ^@ Similarity ^@ Belongs to the FAM102 family. http://togogenome.org/gene/59894:LOC101813295 ^@ http://purl.uniprot.org/uniprot/U3K4J0 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/59894:UTRN ^@ http://purl.uniprot.org/uniprot/A0A803V8F7|||http://purl.uniprot.org/uniprot/A0A803W8P9|||http://purl.uniprot.org/uniprot/U3KF18 ^@ Function|||Subcellular Location Annotation ^@ May play a role in anchoring the cytoskeleton to the plasma membrane.|||cytoskeleton http://togogenome.org/gene/59894:GPR20 ^@ http://purl.uniprot.org/uniprot/U3KJB4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:RPLP0 ^@ http://purl.uniprot.org/uniprot/U3JYW6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL10 family.|||Ribosomal protein P0 is the functional equivalent of E.coli protein L10. http://togogenome.org/gene/59894:TBX15 ^@ http://purl.uniprot.org/uniprot/U3JR47 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:CEP162 ^@ http://purl.uniprot.org/uniprot/A0A803VI47 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP162 family.|||centriole http://togogenome.org/gene/59894:HKDC1 ^@ http://purl.uniprot.org/uniprot/U3KFA6 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/59894:CLK4 ^@ http://purl.uniprot.org/uniprot/U3JZ10 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:FGF13 ^@ http://purl.uniprot.org/uniprot/A0A803VX76|||http://purl.uniprot.org/uniprot/U3JMD9|||http://purl.uniprot.org/uniprot/U3JME2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||dendrite|||filopodium|||growth cone|||sarcolemma http://togogenome.org/gene/59894:CWC15 ^@ http://purl.uniprot.org/uniprot/A0A803W3A7 ^@ Similarity ^@ Belongs to the CWC15 family. http://togogenome.org/gene/59894:HTR1A ^@ http://purl.uniprot.org/uniprot/U3KJC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101812766 ^@ http://purl.uniprot.org/uniprot/U3JXA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RRM NCBP2 family.|||Component of the cap-binding complex (CBC), which binds co-transcriptionally to the 5' cap of pre-mRNAs and is involved in various processes such as pre-mRNA splicing, translation regulation, nonsense-mediated mRNA decay, RNA-mediated gene silencing (RNAi) by microRNAs (miRNAs) and mRNA export. The CBC complex is involved in mRNA export from the nucleus, leading to the recruitment of the mRNA export machinery to the 5' end of mRNA and to mRNA export in a 5' to 3' direction through the nuclear pore. The CBC complex is also involved in mediating U snRNA and intronless mRNAs export from the nucleus. The CBC complex is essential for a pioneer round of mRNA translation, before steady state translation when the CBC complex is replaced by cytoplasmic cap-binding protein eIF4E. The pioneer round of mRNA translation mediated by the CBC complex plays a central role in nonsense-mediated mRNA decay (NMD), NMD only taking place in mRNAs bound to the CBC complex, but not on eIF4E-bound mRNAs. The CBC complex enhances NMD in mRNAs containing at least one exon-junction complex (EJC), promoting the interaction between upf1 and upf2. The CBC complex is also involved in 'failsafe' NMD, which is independent of the EJC complex, while it does not participate in Staufen-mediated mRNA decay (SMD). During cell proliferation, the CBC complex is also involved in microRNAs (miRNAs) biogenesis via its interaction with srrt/ars2, thereby being required for miRNA-mediated RNA interference. The CBC complex also acts as a negative regulator of parn, thereby acting as an inhibitor of mRNA deadenylation. In the CBC complex, ncbp2/cbp20 recognizes and binds capped RNAs (m7GpppG-capped RNA) but requires ncbp1/cbp80 to stabilize the movement of its N-terminal loop and lock the CBC into a high affinity cap-binding state with the cap structure. The conventional cap-binding complex with NCBP2 binds both small nuclear RNA (snRNA) and messenger (mRNA) and is involved in their export from the nucleus.|||Component of the nuclear cap-binding complex (CBC), a heterodimer composed of ncbp1/cbp80 and ncbp2/cbp20 that interacts with m7GpppG-capped RNA.|||Nucleus http://togogenome.org/gene/59894:HNF1B ^@ http://purl.uniprot.org/uniprot/U3JRC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/59894:NMBR ^@ http://purl.uniprot.org/uniprot/U3KE97 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:C18H17orf62 ^@ http://purl.uniprot.org/uniprot/A0A803WG09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYBC1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:SLC9A3 ^@ http://purl.uniprot.org/uniprot/A0A803VKJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Membrane http://togogenome.org/gene/59894:LOC101811783 ^@ http://purl.uniprot.org/uniprot/A0A803W473 ^@ Subcellular Location Annotation ^@ Nucleus|||telomere http://togogenome.org/gene/59894:GATA5 ^@ http://purl.uniprot.org/uniprot/U3K7K2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CDC42SE2 ^@ http://purl.uniprot.org/uniprot/A0A803VIK5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/59894:BASP1 ^@ http://purl.uniprot.org/uniprot/U3KIR0 ^@ Similarity ^@ Belongs to the BASP1 family. http://togogenome.org/gene/59894:TAT ^@ http://purl.uniprot.org/uniprot/U3JIT8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the class-I pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer.|||Transaminase involved in tyrosine breakdown. Converts tyrosine to p-hydroxyphenylpyruvate. http://togogenome.org/gene/59894:VPS11 ^@ http://purl.uniprot.org/uniprot/A0A803V4L8|||http://purl.uniprot.org/uniprot/U3K5E5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS11 family.|||Cytoplasmic vesicle|||Early endosome|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport and autophagic pathways. Believed to act as a core component of the putative HOPS and CORVET endosomal tethering complexes.|||autophagosome|||clathrin-coated vesicle http://togogenome.org/gene/59894:GLE1 ^@ http://purl.uniprot.org/uniprot/A0A803VVZ9|||http://purl.uniprot.org/uniprot/U3JFB0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLE1 family.|||Required for the export of mRNAs containing poly(A) tails from the nucleus into the cytoplasm. May be involved in the terminal step of the mRNA transport through the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/59894:SLC23A3 ^@ http://purl.uniprot.org/uniprot/U3JNK1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PHTF1 ^@ http://purl.uniprot.org/uniprot/U3JLK3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SBNO1 ^@ http://purl.uniprot.org/uniprot/U3K3R4 ^@ Similarity ^@ Belongs to the SBNO family. http://togogenome.org/gene/59894:TACR2 ^@ http://purl.uniprot.org/uniprot/U3KFB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101811809 ^@ http://purl.uniprot.org/uniprot/U3KL33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/59894:SLC29A3 ^@ http://purl.uniprot.org/uniprot/U3KG01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/59894:MID1IP1 ^@ http://purl.uniprot.org/uniprot/U3KJE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SLC43A3 ^@ http://purl.uniprot.org/uniprot/U3K9L7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MGST3 ^@ http://purl.uniprot.org/uniprot/U3JZU5 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:SKP1 ^@ http://purl.uniprot.org/uniprot/U3JZR0 ^@ Similarity ^@ Belongs to the SKP1 family. http://togogenome.org/gene/59894:GRIN2A ^@ http://purl.uniprot.org/uniprot/U3JN01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system.|||Synaptic cell membrane http://togogenome.org/gene/59894:LOC107604091 ^@ http://purl.uniprot.org/uniprot/U3JR04 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/59894:DIEXF ^@ http://purl.uniprot.org/uniprot/U3KDM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP25 family.|||nucleolus http://togogenome.org/gene/59894:CROT ^@ http://purl.uniprot.org/uniprot/U3JYZ4 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/59894:LIN54 ^@ http://purl.uniprot.org/uniprot/A0A803VW85|||http://purl.uniprot.org/uniprot/U3JSX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the lin-54 family.|||Nucleus http://togogenome.org/gene/59894:LOC101819738 ^@ http://purl.uniprot.org/uniprot/U3KK88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/59894:GNB5 ^@ http://purl.uniprot.org/uniprot/U3KBJ0 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/59894:DUSP10 ^@ http://purl.uniprot.org/uniprot/U3KC19 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/59894:NEU2 ^@ http://purl.uniprot.org/uniprot/U3KGF1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 33 family. http://togogenome.org/gene/59894:LOC101820808 ^@ http://purl.uniprot.org/uniprot/U3KA14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the INCENP family.|||Midbody|||Nucleus|||kinetochore|||spindle http://togogenome.org/gene/59894:MAN1A1 ^@ http://purl.uniprot.org/uniprot/A0A803VPW3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/59894:IFITM10 ^@ http://purl.uniprot.org/uniprot/U3KB40 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:ABCC3 ^@ http://purl.uniprot.org/uniprot/U3JF95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCC family. Conjugate transporter (TC 3.A.1.208) subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NOX1 ^@ http://purl.uniprot.org/uniprot/U3JML0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PDE2A ^@ http://purl.uniprot.org/uniprot/U3JUQ9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:MTCH2 ^@ http://purl.uniprot.org/uniprot/U3JF06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:MAN1B1 ^@ http://purl.uniprot.org/uniprot/U3JQC3 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/59894:DLGAP3 ^@ http://purl.uniprot.org/uniprot/U3JD96 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/59894:PRKAA1 ^@ http://purl.uniprot.org/uniprot/U3JH39 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/59894:FAM160A1 ^@ http://purl.uniprot.org/uniprot/U3JWD0 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/59894:EMP1 ^@ http://purl.uniprot.org/uniprot/U3KAB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PMP-22/EMP/MP20 family.|||Membrane http://togogenome.org/gene/59894:RNF121 ^@ http://purl.uniprot.org/uniprot/A0A803VK41|||http://purl.uniprot.org/uniprot/U3JUX5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:KCNT1 ^@ http://purl.uniprot.org/uniprot/U3JGF9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:SLC2A12 ^@ http://purl.uniprot.org/uniprot/A0A803VT47|||http://purl.uniprot.org/uniprot/U3KBJ7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:RBM17 ^@ http://purl.uniprot.org/uniprot/U3JGF8 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Associates with the spliceosome.|||Nucleus|||Splice factor that binds to the single-stranded 3'AG at the exon/intron border and promotes its utilization in the second catalytic step. Involved in the regulation of alternative splicing and the utilization of cryptic splice sites. http://togogenome.org/gene/59894:CHAF1B ^@ http://purl.uniprot.org/uniprot/U3K770 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101808676 ^@ http://purl.uniprot.org/uniprot/A0A803W7E2 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:CALCRL ^@ http://purl.uniprot.org/uniprot/U3JPH5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for calcitonin-gene-related peptide (CGRP). Receptor specificity may be modulated by accessory proteins. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/59894:HOXA5 ^@ http://purl.uniprot.org/uniprot/A0A803VJI3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59894:RBFOX2 ^@ http://purl.uniprot.org/uniprot/A0A803W5D1|||http://purl.uniprot.org/uniprot/A0A803W7N4|||http://purl.uniprot.org/uniprot/U3KF85 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/59894:PPP2R2A ^@ http://purl.uniprot.org/uniprot/A0A803WA87|||http://purl.uniprot.org/uniprot/A0A803WER0 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B family. http://togogenome.org/gene/59894:TMEM38B ^@ http://purl.uniprot.org/uniprot/U3JJQ6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/59894:KCNC1 ^@ http://purl.uniprot.org/uniprot/U3JDC5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:OPN3 ^@ http://purl.uniprot.org/uniprot/A0A803VZT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59894:LIAS ^@ http://purl.uniprot.org/uniprot/A0A803WDT1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the radical SAM superfamily. Lipoyl synthase family.|||Binds 2 [4Fe-4S] clusters per subunit. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives.|||Mitochondrion http://togogenome.org/gene/59894:LOC101808625 ^@ http://purl.uniprot.org/uniprot/A0A803W357|||http://purl.uniprot.org/uniprot/U3K2F7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARTD/PARP family.|||Nucleus http://togogenome.org/gene/59894:IER3IP1 ^@ http://purl.uniprot.org/uniprot/A0A803VPC1 ^@ Similarity ^@ Belongs to the YOS1 family. http://togogenome.org/gene/59894:RPRD1B ^@ http://purl.uniprot.org/uniprot/U3JPG7 ^@ Similarity ^@ Belongs to the UPF0400 (RTT103) family. http://togogenome.org/gene/59894:TM2D1 ^@ http://purl.uniprot.org/uniprot/A0A803VJQ6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101811547 ^@ http://purl.uniprot.org/uniprot/U3JKG4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha/beta interferon family.|||Has antiviral activities.|||Secreted http://togogenome.org/gene/59894:CNOT8 ^@ http://purl.uniprot.org/uniprot/U3K0Z9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAF1 family.|||Nucleus http://togogenome.org/gene/59894:CORO2A ^@ http://purl.uniprot.org/uniprot/A0A803V8Y3 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/59894:ANKRD13A ^@ http://purl.uniprot.org/uniprot/A0A803VCT9|||http://purl.uniprot.org/uniprot/U3K200 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/59894:SLC31A1 ^@ http://purl.uniprot.org/uniprot/A0A803VH51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the copper transporter (Ctr) (TC 1.A.56) family. SLC31A subfamily.|||Membrane http://togogenome.org/gene/59894:STX18 ^@ http://purl.uniprot.org/uniprot/A0A803V8X6|||http://purl.uniprot.org/uniprot/A0A803V9K0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DDX58 ^@ http://purl.uniprot.org/uniprot/U3JEK4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RLR subfamily.|||Cytoplasm http://togogenome.org/gene/59894:SWI5 ^@ http://purl.uniprot.org/uniprot/A0A803VG18 ^@ Function|||Similarity ^@ Belongs to the SWI5/SAE3 family.|||Component of the swi5-sfr1 complex, a complex required for double-strand break repair via homologous recombination. http://togogenome.org/gene/59894:CAND1 ^@ http://purl.uniprot.org/uniprot/A0A803VPA9|||http://purl.uniprot.org/uniprot/U3K641 ^@ Similarity ^@ Belongs to the CAND family. http://togogenome.org/gene/59894:CDCA7L ^@ http://purl.uniprot.org/uniprot/U3K558 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CFAP97 ^@ http://purl.uniprot.org/uniprot/U3KBG9 ^@ Similarity ^@ Belongs to the CFAP97 family. http://togogenome.org/gene/59894:CDKN1A ^@ http://purl.uniprot.org/uniprot/A0A803VE43|||http://purl.uniprot.org/uniprot/U3JKS9 ^@ Similarity ^@ Belongs to the CDI family. http://togogenome.org/gene/59894:DBNL ^@ http://purl.uniprot.org/uniprot/A0A803VPA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABP1 family.|||Cell membrane|||Early endosome|||Endosome|||Golgi apparatus membrane|||Perikaryon|||Postsynaptic density|||Synapse|||cell cortex|||clathrin-coated vesicle membrane|||cytoskeleton|||dendrite|||lamellipodium|||neuron projection|||podosome|||ruffle http://togogenome.org/gene/59894:LOC101807523 ^@ http://purl.uniprot.org/uniprot/A0A803VXE6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Refilin family.|||Interacts with FLNA and FLNB.|||cytoskeleton http://togogenome.org/gene/59894:SMDT1 ^@ http://purl.uniprot.org/uniprot/U3KB44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SMDT1/EMRE family.|||Component of the uniplex complex. Interacts (via the transmembrane region) with MCU (via the first transmembrane region); the interaction is direct.|||Essential regulatory subunit of the mitochondrial calcium uniporter complex (uniplex), a complex that mediates calcium uptake into mitochondria.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:NCF2 ^@ http://purl.uniprot.org/uniprot/U3JK78 ^@ Similarity ^@ Belongs to the NCF2/NOXA1 family. http://togogenome.org/gene/59894:MTRF1 ^@ http://purl.uniprot.org/uniprot/U3K030 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/59894:LOC101821391 ^@ http://purl.uniprot.org/uniprot/A0A803WE46 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:TRIP12 ^@ http://purl.uniprot.org/uniprot/U3JWW4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UPL family. K-HECT subfamily.|||E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins.|||nucleoplasm http://togogenome.org/gene/59894:TBP ^@ http://purl.uniprot.org/uniprot/A0A803VZX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBP family.|||Nucleus http://togogenome.org/gene/59894:LYRM1 ^@ http://purl.uniprot.org/uniprot/A0A803W3N3 ^@ Similarity ^@ Belongs to the complex I LYR family. http://togogenome.org/gene/59894:LOC101819122 ^@ http://purl.uniprot.org/uniprot/A0A803WDC5|||http://purl.uniprot.org/uniprot/U3K864 ^@ Function|||Miscellaneous|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sulfur carrier required for molybdopterin biosynthesis. Component of the molybdopterin synthase complex that catalyzes the conversion of precursor Z into molybdopterin by mediating the incorporation of 2 sulfur atoms into precursor Z to generate a dithiolene group. In the complex, serves as sulfur donor by being thiocarboxylated (-COSH) at its C-terminus by MOCS3. After interaction with MOCS2B, the sulfur is then transferred to precursor Z to form molybdopterin.|||Belongs to the MoaD family. MOCS2A subfamily.|||Belongs to the MoaE family. MOCS2B subfamily.|||C-terminal thiocarboxylation occurs in 2 steps, it is first acyl-adenylated (-COAMP) via the hesA/moeB/thiF part of MOCS3, then thiocarboxylated (-COSH) via the rhodanese domain of MOCS3.|||Catalytic subunit of the molybdopterin synthase complex, a complex that catalyzes the conversion of precursor Z into molybdopterin. Acts by mediating the incorporation of 2 sulfur atoms from thiocarboxylated MOCS2A into precursor Z to generate a dithiolene group.|||Heterotetramer; composed of 2 small (MOCS2A) and 2 large (MOCS2B) subunits.|||This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2A).|||This protein is produced by a bicistronic gene which also produces the large subunit (MOCS2B).|||cytosol http://togogenome.org/gene/59894:LOC101812762 ^@ http://purl.uniprot.org/uniprot/U3KGW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PKNOX1 ^@ http://purl.uniprot.org/uniprot/U3JGZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/59894:FAM160B1 ^@ http://purl.uniprot.org/uniprot/U3JHR8 ^@ Similarity ^@ Belongs to the FHIP family. http://togogenome.org/gene/59894:LOC101805746 ^@ http://purl.uniprot.org/uniprot/A0A803WGD0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:SIGIRR ^@ http://purl.uniprot.org/uniprot/U3KAK0 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59894:PAQR9 ^@ http://purl.uniprot.org/uniprot/A0A803VFP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59894:CKB ^@ http://purl.uniprot.org/uniprot/A0A803VF24|||http://purl.uniprot.org/uniprot/U3JJL5 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/59894:XG ^@ http://purl.uniprot.org/uniprot/U3JNK4 ^@ Similarity ^@ Belongs to the CD99 family. http://togogenome.org/gene/59894:LOC101808986 ^@ http://purl.uniprot.org/uniprot/U3KGG3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/59894:TMSB15B ^@ http://purl.uniprot.org/uniprot/A0A803WFQ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/59894:MAB21L3 ^@ http://purl.uniprot.org/uniprot/U3JUC1 ^@ Similarity ^@ Belongs to the mab-21 family. http://togogenome.org/gene/59894:AGTR1 ^@ http://purl.uniprot.org/uniprot/U3KLD4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for angiotensin II, a vasoconstricting peptide, which acts as a key regulator of blood pressure and sodium retention by the kidney. The activated receptor in turn couples to G-alpha proteins G(q) and thus activates phospholipase C and increases the cytosolic Ca(2+) concentrations, which in turn triggers cellular responses such as stimulation of protein kinase C. http://togogenome.org/gene/59894:LOC101812234 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:LOC101807254 ^@ http://purl.uniprot.org/uniprot/U3JXP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UDP-glycosyltransferase family.|||Membrane http://togogenome.org/gene/59894:MFN2 ^@ http://purl.uniprot.org/uniprot/U3K5Y1 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:LOC101817417 ^@ http://purl.uniprot.org/uniprot/A0A803V757|||http://purl.uniprot.org/uniprot/U3KD59 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:CRYAB ^@ http://purl.uniprot.org/uniprot/A0A803VPG7 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/59894:LOC101814351 ^@ http://purl.uniprot.org/uniprot/U3JR96 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/59894:APPL1 ^@ http://purl.uniprot.org/uniprot/U3K1E1 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Nucleus|||phagosome|||ruffle http://togogenome.org/gene/59894:PARG ^@ http://purl.uniprot.org/uniprot/U3JW90 ^@ Similarity ^@ Belongs to the poly(ADP-ribose) glycohydrolase family. http://togogenome.org/gene/59894:RARB ^@ http://purl.uniprot.org/uniprot/U3K3J3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:SEPT5 ^@ http://purl.uniprot.org/uniprot/A0A803W5K4|||http://purl.uniprot.org/uniprot/A0A803WAA0|||http://purl.uniprot.org/uniprot/U3K015 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||cytoskeleton http://togogenome.org/gene/59894:ST6GALNAC4 ^@ http://purl.uniprot.org/uniprot/U3JF14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:ADGRF5 ^@ http://purl.uniprot.org/uniprot/U3JFS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/59894:RNF8 ^@ http://purl.uniprot.org/uniprot/U3K9N1 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CHFR family.|||Belongs to the RNF8 family.|||E3 ubiquitin-protein ligase that plays a key role in DNA damage signaling via 2 distinct roles: by mediating the 'Lys-63'-linked ubiquitination of histones H2A and H2AX and promoting the recruitment of DNA repair proteins at double-strand breaks (DSBs) sites, and by catalyzing 'Lys-48'-linked ubiquitination to remove target proteins from DNA damage sites. Following DNA DSBs, it is recruited to the sites of damage by ATM-phosphorylated MDC1 and catalyzes the 'Lys-63'-linked ubiquitination of histones H2A and H2AX, thereby promoting the formation of TP53BP1 and BRCA1 ionizing radiation-induced foci (IRIF). H2A ubiquitination also mediates the ATM-dependent transcriptional silencing at regions flanking DSBs in cis, a mechanism to avoid collision between transcription and repair intermediates. Also catalyzes the formation of 'Lys-48'-linked polyubiquitin chains, leading to degradation of substrate proteins. In addition to its function in damage signaling, also plays a role in higher-order chromatin structure by mediating extensive chromatin decondensation.|||Homodimer. Forms a E2-E3 ubiquitin ligase complex composed of the RNF8 homodimer and a E2 heterodimer of UBE2N and UBE2V2.|||Nucleus|||The FHA domain specifically recognizes and binds ATM-phosphorylated MDC1. http://togogenome.org/gene/59894:ADORA2B ^@ http://purl.uniprot.org/uniprot/U3JUD1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/59894:SKIL ^@ http://purl.uniprot.org/uniprot/U3K1R1 ^@ Similarity ^@ Belongs to the SKI family. http://togogenome.org/gene/59894:MTERF2 ^@ http://purl.uniprot.org/uniprot/U3KLE5 ^@ Similarity ^@ Belongs to the mTERF family. http://togogenome.org/gene/59894:EED ^@ http://purl.uniprot.org/uniprot/U3JZ14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat ESC family.|||Nucleus http://togogenome.org/gene/59894:TXNL4A ^@ http://purl.uniprot.org/uniprot/U3KFU6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/59894:AIP ^@ http://purl.uniprot.org/uniprot/U3JF43 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with RET in the pituitary gland; this interaction prevents the formation of the AIP-survivin complex.|||May play a positive role in AHR-mediated (aromatic hydrocarbon receptor) signaling, possibly by influencing its receptivity for ligand and/or its nuclear targeting. http://togogenome.org/gene/59894:B4GALT4 ^@ http://purl.uniprot.org/uniprot/U3JU76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/59894:METRNL ^@ http://purl.uniprot.org/uniprot/U3JD87 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the meteorin family.|||Secreted http://togogenome.org/gene/59894:DR1 ^@ http://purl.uniprot.org/uniprot/A0A803V4N1 ^@ Similarity ^@ Belongs to the NC2 beta/DR1 family. http://togogenome.org/gene/59894:C1H2orf40 ^@ http://purl.uniprot.org/uniprot/U3JLV2 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the augurin family.|||Cytoplasm|||Membrane|||Secreted http://togogenome.org/gene/59894:PLAG1 ^@ http://purl.uniprot.org/uniprot/A0A803VSD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/59894:MANEA ^@ http://purl.uniprot.org/uniprot/A0A803W2D5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 99 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:SEMA5B ^@ http://purl.uniprot.org/uniprot/A0A803VQH2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101820149 ^@ http://purl.uniprot.org/uniprot/U3JSV0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hcp beta-lactamase family.|||Mitochondrion intermembrane space http://togogenome.org/gene/59894:PTS ^@ http://purl.uniprot.org/uniprot/U3JUN8 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the PTPS family.|||Binds 1 zinc ion per subunit.|||Involved in the biosynthesis of tetrahydrobiopterin, an essential cofactor of aromatic amino acid hydroxylases. Catalyzes the transformation of 7,8-dihydroneopterin triphosphate into 6-pyruvoyl tetrahydropterin. http://togogenome.org/gene/59894:GLRX2 ^@ http://purl.uniprot.org/uniprot/U3JJS7 ^@ Function ^@ Has a glutathione-disulfide oxidoreductase activity in the presence of NADPH and glutathione reductase. Reduces low molecular weight disulfides and proteins. http://togogenome.org/gene/59894:EIF5 ^@ http://purl.uniprot.org/uniprot/U3JJJ2 ^@ Function|||Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family.|||Catalyzes the hydrolysis of GTP bound to the 40S ribosomal initiation complex (40S.mRNA.Met-tRNA[F].eIF-2.GTP) with the subsequent joining of a 60S ribosomal subunit resulting in the release of eIF-2 and the guanine nucleotide. The subsequent joining of a 60S ribosomal subunit results in the formation of a functional 80S initiation complex (80S.mRNA.Met-tRNA[F]). http://togogenome.org/gene/59894:LOC101817341 ^@ http://purl.uniprot.org/uniprot/U3JLA3 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||nucleolus http://togogenome.org/gene/59894:BORCS7 ^@ http://purl.uniprot.org/uniprot/A0A803VGX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS7 family.|||Membrane http://togogenome.org/gene/59894:SSR2 ^@ http://purl.uniprot.org/uniprot/A0A803V9C5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAP-beta family.|||Endoplasmic reticulum membrane|||Heterotetramer of TRAP-alpha, TRAP-beta, TRAP-delta and TRAP-gamma.|||Membrane|||TRAP proteins are part of a complex whose function is to bind calcium to the ER membrane and thereby regulate the retention of ER resident proteins. http://togogenome.org/gene/59894:ARSK ^@ http://purl.uniprot.org/uniprot/U3K385 ^@ PTM ^@ The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:VIM ^@ http://purl.uniprot.org/uniprot/U3JYD1 ^@ Function|||Similarity ^@ Belongs to the intermediate filament family.|||Vimentins are class-III intermediate filaments found in various non-epithelial cells, especially mesenchymal cells. Vimentin is attached to the nucleus, endoplasmic reticulum, and mitochondria, either laterally or terminally. http://togogenome.org/gene/59894:TMOD1 ^@ http://purl.uniprot.org/uniprot/A0A803VD13|||http://purl.uniprot.org/uniprot/U3JEM3 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:ATP5L ^@ http://purl.uniprot.org/uniprot/A0A803W1F2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase g subunit family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core, and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F(0) domain. Minor subunit located with subunit a in the membrane.|||Mitochondrial membrane ATP synthase (F1F0 ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F1 - containing the extramembraneous catalytic core, and F0 - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F1 is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Part of the complex F0 domain. Minor subunit located with subunit a in the membrane.|||Mitochondrion http://togogenome.org/gene/59894:SUSD6 ^@ http://purl.uniprot.org/uniprot/U3JQX5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:SULT4A1 ^@ http://purl.uniprot.org/uniprot/U3JVY2 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:LOC101807492 ^@ http://purl.uniprot.org/uniprot/A0A803VN62|||http://purl.uniprot.org/uniprot/U3KBD3 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. BTD/VNN family. http://togogenome.org/gene/59894:LOC101813351 ^@ http://purl.uniprot.org/uniprot/U3JPA8 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/59894:ITFG1 ^@ http://purl.uniprot.org/uniprot/U3JBH9 ^@ Similarity ^@ Belongs to the TIP family. http://togogenome.org/gene/59894:LOC101816697 ^@ http://purl.uniprot.org/uniprot/U3K1G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Secreted http://togogenome.org/gene/59894:SRSF5 ^@ http://purl.uniprot.org/uniprot/U3JQX1 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/59894:LAMTOR5 ^@ http://purl.uniprot.org/uniprot/U3JKA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMTOR5 family.|||Lysosome http://togogenome.org/gene/59894:TFCP2L1 ^@ http://purl.uniprot.org/uniprot/U3KFK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/59894:EHHADH ^@ http://purl.uniprot.org/uniprot/U3KG80 ^@ Similarity ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||In the N-terminal section; belongs to the enoyl-CoA hydratase/isomerase family. http://togogenome.org/gene/59894:ACTR8 ^@ http://purl.uniprot.org/uniprot/A0A803W7D5|||http://purl.uniprot.org/uniprot/U3K1P4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the actin family. ARP8 subfamily.|||Chromosome|||Component of the chromatin remodeling INO80 complex; specifically part of a complex module associated with the DBINO domain of INO80. Exists as monomers and dimers, but the dimer is most probably the biologically relevant form required for stable interactions with histones that exploits the twofold symmetry of the nucleosome core.|||Nucleus|||Plays an important role in the functional organization of mitotic chromosomes. Exhibits low basal ATPase activity, and unable to polymerize.|||Proposed core component of the chromatin remodeling INO80 complex which is involved in transcriptional regulation, DNA replication and probably DNA repair. http://togogenome.org/gene/59894:MCM8 ^@ http://purl.uniprot.org/uniprot/U3KGL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/59894:TMEM8C ^@ http://purl.uniprot.org/uniprot/U3JFR6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NKX6-2 ^@ http://purl.uniprot.org/uniprot/U3JF17 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PLEKHA8 ^@ http://purl.uniprot.org/uniprot/U3K3V6 ^@ Subcellular Location Annotation ^@ Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:CSGALNACT1 ^@ http://purl.uniprot.org/uniprot/U3JVN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:S100Z ^@ http://purl.uniprot.org/uniprot/A0A803VFY7 ^@ Similarity ^@ Belongs to the S-100 family. http://togogenome.org/gene/59894:GLP2R ^@ http://purl.uniprot.org/uniprot/U3JD61 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TYRO3 ^@ http://purl.uniprot.org/uniprot/U3JU80 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Membrane http://togogenome.org/gene/59894:ATHL1 ^@ http://purl.uniprot.org/uniprot/U3KAG2 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:MAPRE2 ^@ http://purl.uniprot.org/uniprot/U3JTJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPRE family.|||cytoskeleton http://togogenome.org/gene/59894:TRPM6 ^@ http://purl.uniprot.org/uniprot/A0A803VYG9 ^@ Similarity|||Subcellular Location Annotation ^@ In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/59894:PTPN6 ^@ http://purl.uniprot.org/uniprot/A0A803VH52|||http://purl.uniprot.org/uniprot/A0A803W6U4|||http://purl.uniprot.org/uniprot/U3JPY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class 2 subfamily.|||Cytoplasm http://togogenome.org/gene/59894:TRPC1 ^@ http://purl.uniprot.org/uniprot/U3JX68 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TPX2 ^@ http://purl.uniprot.org/uniprot/U3JSL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TPX2 family.|||Nucleus|||spindle pole http://togogenome.org/gene/59894:SLCO1C1 ^@ http://purl.uniprot.org/uniprot/U3K0B2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101809285 ^@ http://purl.uniprot.org/uniprot/U3KHA8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/59894:MFNG ^@ http://purl.uniprot.org/uniprot/A0A803VXM6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CENPU ^@ http://purl.uniprot.org/uniprot/A0A803UZY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-U/AME1 family.|||Nucleus http://togogenome.org/gene/59894:CAMSAP1 ^@ http://purl.uniprot.org/uniprot/A0A803WFH2|||http://purl.uniprot.org/uniprot/U3JGF5 ^@ Domain|||Similarity ^@ Belongs to the CAMSAP1 family.|||The CKK domain binds microtubules. http://togogenome.org/gene/59894:MAFK ^@ http://purl.uniprot.org/uniprot/A0A803W4E3 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/59894:HEPHL1 ^@ http://purl.uniprot.org/uniprot/A0A803VB58 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/59894:YES1 ^@ http://purl.uniprot.org/uniprot/A0A803VWC2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:YIPF5 ^@ http://purl.uniprot.org/uniprot/U3K2U2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the YIP1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TTC39A ^@ http://purl.uniprot.org/uniprot/A0A803V8U2 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/59894:FABP5 ^@ http://purl.uniprot.org/uniprot/U3K1U5 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:AGPAT2 ^@ http://purl.uniprot.org/uniprot/U3JG60 ^@ Domain|||Function|||Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family.|||Converts 1-acyl-sn-glycerol-3-phosphate (lysophosphatidic acid or LPA) into 1,2-diacyl-sn-glycerol-3-phosphate (phosphatidic acid or PA) by incorporating an acyl moiety at the sn-2 position of the glycerol backbone.|||The HXXXXD motif is essential for acyltransferase activity and may constitute the binding site for the phosphate moiety of the glycerol-3-phosphate. http://togogenome.org/gene/59894:DAP3 ^@ http://purl.uniprot.org/uniprot/U3JJK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS29 family.|||Mitochondrion http://togogenome.org/gene/59894:WNT10A ^@ http://purl.uniprot.org/uniprot/U3JNI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:MPG ^@ http://purl.uniprot.org/uniprot/U3JN92 ^@ Function|||Similarity ^@ Belongs to the DNA glycosylase MPG family.|||Hydrolysis of the deoxyribose N-glycosidic bond to excise 3-methyladenine, and 7-methylguanine from the damaged DNA polymer formed by alkylation lesions. http://togogenome.org/gene/59894:LOC101816129 ^@ http://purl.uniprot.org/uniprot/A0A803VHI2 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59894:RNF182 ^@ http://purl.uniprot.org/uniprot/U3KK90 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/59894:PTER ^@ http://purl.uniprot.org/uniprot/A0A803VP81 ^@ Caution|||Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Phosphotriesterase family.|||Binds 2 divalent metal cations per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:IARS ^@ http://purl.uniprot.org/uniprot/U3K6P5 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:SMC2 ^@ http://purl.uniprot.org/uniprot/U3JBN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC2 subfamily.|||Chromosome|||Nucleus http://togogenome.org/gene/59894:STARD3 ^@ http://purl.uniprot.org/uniprot/U3JCR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/59894:GGA3 ^@ http://purl.uniprot.org/uniprot/A0A803VSY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:IP6K3 ^@ http://purl.uniprot.org/uniprot/U3JMM5 ^@ Similarity ^@ Belongs to the inositol phosphokinase (IPK) family. http://togogenome.org/gene/59894:SPON1 ^@ http://purl.uniprot.org/uniprot/U3K832 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/59894:VAT1L ^@ http://purl.uniprot.org/uniprot/U3JBW7 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. Quinone oxidoreductase subfamily. http://togogenome.org/gene/59894:LOC101811383 ^@ http://purl.uniprot.org/uniprot/U3JSG8 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/59894:ESRP2 ^@ http://purl.uniprot.org/uniprot/A0A803V9P0|||http://purl.uniprot.org/uniprot/U3JZ81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESRP family.|||Nucleus http://togogenome.org/gene/59894:ST6GAL1 ^@ http://purl.uniprot.org/uniprot/U3JN27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:OPN5 ^@ http://purl.uniprot.org/uniprot/U3JFW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:THBS4 ^@ http://purl.uniprot.org/uniprot/U3K5J9 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:AK1 ^@ http://purl.uniprot.org/uniprot/A0A803V5B7|||http://purl.uniprot.org/uniprot/U3JF18 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK1 subfamily.|||Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Also displays broad nucleoside diphosphate kinase activity. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon ATP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent ATP hydrolysis.|||Cytoplasm|||Monomer. http://togogenome.org/gene/59894:LHFPL2 ^@ http://purl.uniprot.org/uniprot/A0A803VDF7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DDX1 ^@ http://purl.uniprot.org/uniprot/U3K215 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DDX1 subfamily.|||Cytoplasmic granule http://togogenome.org/gene/59894:LOC101807262 ^@ http://purl.uniprot.org/uniprot/A0A803VPD8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 13 family. http://togogenome.org/gene/59894:SBDS ^@ http://purl.uniprot.org/uniprot/A0A803W360 ^@ Function|||Similarity ^@ Belongs to the SDO1/SBDS family.|||Required for the assembly of mature ribosomes and ribosome biogenesis. Together with EFL1, triggers the GTP-dependent release of EIF6 from 60S pre-ribosomes in the cytoplasm, thereby activating ribosomes for translation competence by allowing 80S ribosome assembly and facilitating EIF6 recycling to the nucleus, where it is required for 60S rRNA processing and nuclear export. Required for normal levels of protein synthesis. May play a role in cellular stress resistance. May play a role in cellular response to DNA damage. May play a role in cell proliferation. http://togogenome.org/gene/59894:SLC13A1 ^@ http://purl.uniprot.org/uniprot/U3K5N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59894:REEP1 ^@ http://purl.uniprot.org/uniprot/A0A803VND9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DP1 family.|||Membrane http://togogenome.org/gene/59894:GCNT1 ^@ http://purl.uniprot.org/uniprot/U3KJH7 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101813454 ^@ http://purl.uniprot.org/uniprot/U3JPL5 ^@ Subcellular Location Annotation ^@ Membrane|||chromaffin granule membrane http://togogenome.org/gene/59894:BID ^@ http://purl.uniprot.org/uniprot/U3K4T9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:C7 ^@ http://purl.uniprot.org/uniprot/U3JH31 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:LOC101814445 ^@ http://purl.uniprot.org/uniprot/U3JLM2 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/59894:KPNA2 ^@ http://purl.uniprot.org/uniprot/U3JI37 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:NECAP1 ^@ http://purl.uniprot.org/uniprot/U3JXP9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NECAP family.|||Involved in endocytosis.|||clathrin-coated vesicle membrane http://togogenome.org/gene/59894:PEBP1 ^@ http://purl.uniprot.org/uniprot/A0A803V8D0 ^@ Similarity ^@ Belongs to the phosphatidylethanolamine-binding protein family. http://togogenome.org/gene/59894:DYX1C1 ^@ http://purl.uniprot.org/uniprot/U3KC26 ^@ Subcellular Location Annotation ^@ Dynein axonemal particle|||neuron projection http://togogenome.org/gene/59894:CHPF2 ^@ http://purl.uniprot.org/uniprot/U3KFH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:MRPS33 ^@ http://purl.uniprot.org/uniprot/A0A803WFY5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS33 family.|||Mitochondrion http://togogenome.org/gene/59894:POMT2 ^@ http://purl.uniprot.org/uniprot/A0A803VEE1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/59894:SDF4 ^@ http://purl.uniprot.org/uniprot/A0A803V188|||http://purl.uniprot.org/uniprot/U3K380 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CREC family.|||Golgi apparatus lumen http://togogenome.org/gene/59894:CA4 ^@ http://purl.uniprot.org/uniprot/A0A803VPY0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the alpha-carbonic anhydrase family.|||Cell membrane|||Interacts with SLC4A4.|||Membrane|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:TPH2 ^@ http://purl.uniprot.org/uniprot/A0A803WAC5|||http://purl.uniprot.org/uniprot/U3K710 ^@ Similarity ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family. http://togogenome.org/gene/59894:NT5C3B ^@ http://purl.uniprot.org/uniprot/U3JCZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pyrimidine 5'-nucleotidase family.|||Cytoplasm http://togogenome.org/gene/59894:LOC101817076 ^@ http://purl.uniprot.org/uniprot/U3JUB0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59894:SIAH3 ^@ http://purl.uniprot.org/uniprot/U3K0I2 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/59894:PSMC5 ^@ http://purl.uniprot.org/uniprot/U3KGR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/59894:TUBA8 ^@ http://purl.uniprot.org/uniprot/U3K4R2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:CLRN2 ^@ http://purl.uniprot.org/uniprot/A0A803VTN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the clarin family.|||Membrane http://togogenome.org/gene/59894:LOC101811424 ^@ http://purl.uniprot.org/uniprot/U3KJC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor T2R family.|||Membrane http://togogenome.org/gene/59894:ADTRP ^@ http://purl.uniprot.org/uniprot/A0A803VIK8|||http://purl.uniprot.org/uniprot/U3KFZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/59894:LOC101812471 ^@ http://purl.uniprot.org/uniprot/U3JH66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/59894:NDUFS8 ^@ http://purl.uniprot.org/uniprot/A0A803VQ51 ^@ Similarity ^@ Belongs to the complex I 23 kDa subunit family. http://togogenome.org/gene/59894:NPBWR1 ^@ http://purl.uniprot.org/uniprot/U3KK50 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SEC22A ^@ http://purl.uniprot.org/uniprot/U3KFW9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/59894:HLF ^@ http://purl.uniprot.org/uniprot/U3JHV4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/59894:GPR155 ^@ http://purl.uniprot.org/uniprot/U3JK42 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:VGLL3 ^@ http://purl.uniprot.org/uniprot/U3JFI9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs.|||Nucleus http://togogenome.org/gene/59894:FAM162A ^@ http://purl.uniprot.org/uniprot/U3JQT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/59894:GATSL2 ^@ http://purl.uniprot.org/uniprot/U3JX27 ^@ Similarity ^@ Belongs to the GATS family. http://togogenome.org/gene/59894:STX12 ^@ http://purl.uniprot.org/uniprot/A0A803VGP8 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:P4HA2 ^@ http://purl.uniprot.org/uniprot/A0A803VQQ2|||http://purl.uniprot.org/uniprot/U3JEE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:SGPL1 ^@ http://purl.uniprot.org/uniprot/U3JSG6 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/59894:KIF3B ^@ http://purl.uniprot.org/uniprot/A0A803W926|||http://purl.uniprot.org/uniprot/U3JS97 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:IRF1 ^@ http://purl.uniprot.org/uniprot/A0A803V075 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Cytoplasm|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:LOC101808519 ^@ http://purl.uniprot.org/uniprot/U3KD29 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:CALHM1 ^@ http://purl.uniprot.org/uniprot/U3K2A6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59894:LOC101818037 ^@ http://purl.uniprot.org/uniprot/U3K4N4 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/59894:RAPGEF2 ^@ http://purl.uniprot.org/uniprot/A0A803V831|||http://purl.uniprot.org/uniprot/A0A803VCM2|||http://purl.uniprot.org/uniprot/A0A803VPY7|||http://purl.uniprot.org/uniprot/U3JK34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RAPGEF2 family.|||Cell junction|||Endosome|||Late endosome|||perinuclear region http://togogenome.org/gene/59894:ATF2 ^@ http://purl.uniprot.org/uniprot/A0A803VC97|||http://purl.uniprot.org/uniprot/U3JKA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family.|||Binds DNA as a dimer and can form a homodimer in the absence of DNA.|||Nucleus|||Transcriptional activator which regulates the transcription of various genes, including those involved in anti-apoptosis, cell growth, and DNA damage response. Dependent on its binding partner, binds to CRE (cAMP response element) consensus sequences (5'-TGACGTCA-3') or to AP-1 (activator protein 1) consensus sequences (5'-TGACTCA-3'). http://togogenome.org/gene/59894:PSMD9 ^@ http://purl.uniprot.org/uniprot/A0A803VK46 ^@ Similarity ^@ Belongs to the proteasome subunit p27 family. http://togogenome.org/gene/59894:NFYA ^@ http://purl.uniprot.org/uniprot/A0A803W6A7|||http://purl.uniprot.org/uniprot/U3JJW8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NFYA/HAP2 subunit family.|||Component of the sequence-specific heterotrimeric transcription factor (NF-Y) which specifically recognizes a 5'-CCAAT-3' box motif found in the promoters of its target genes.|||Heterotrimer.|||Nucleus http://togogenome.org/gene/59894:UROC1 ^@ http://purl.uniprot.org/uniprot/U3KDR9 ^@ Similarity ^@ Belongs to the urocanase family. http://togogenome.org/gene/59894:ISL1 ^@ http://purl.uniprot.org/uniprot/U3K9T9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LHX1 ^@ http://purl.uniprot.org/uniprot/U3JRU9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:NPSR1 ^@ http://purl.uniprot.org/uniprot/U3JJ82 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:ST3GAL1 ^@ http://purl.uniprot.org/uniprot/A0A803VL42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:IFT57 ^@ http://purl.uniprot.org/uniprot/A0A803V514|||http://purl.uniprot.org/uniprot/U3JVE8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFT57 family.|||cilium basal body http://togogenome.org/gene/59894:SUPT6H ^@ http://purl.uniprot.org/uniprot/U3JV64 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SPT6 family.|||Nucleus|||Transcription elongation factor that enhances transcription elongation by RNA polymerase II (RNAPII). http://togogenome.org/gene/59894:C25H1orf43 ^@ http://purl.uniprot.org/uniprot/U3JEM4 ^@ Function|||Subcellular Location Annotation ^@ General regulator of phagocytosis. Required to uptake Gram negative bacterium by macrophages.|||Golgi apparatus|||Membrane|||Mitochondrion http://togogenome.org/gene/59894:CHST13 ^@ http://purl.uniprot.org/uniprot/A0A803V3M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:ELOVL5 ^@ http://purl.uniprot.org/uniprot/A0A803VPD7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL5 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that acts specifically toward polyunsaturated acyl-CoA with the higher activity toward C18:3(n-6) acyl-CoA. May participate to the production of monounsaturated and of polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||dendrite http://togogenome.org/gene/59894:MAEL ^@ http://purl.uniprot.org/uniprot/U3JFR1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the maelstrom family.|||Nucleus|||Plays a central role during spermatogenesis by repressing transposable elements and preventing their mobilization, which is essential for the germline integrity. Acts via the piRNA metabolic process, which mediates the repression of transposable elements during meiosis by forming complexes composed of piRNAs and Piwi proteins and governs the methylation and subsequent repression of transposons. Its association with piP-bodies suggests a participation in the secondary piRNAs metabolic process. Required for the localization of germ-cell factors to the meiotic nuage. http://togogenome.org/gene/59894:BCO2 ^@ http://purl.uniprot.org/uniprot/U3JUM2 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/59894:TPM4 ^@ http://purl.uniprot.org/uniprot/A0A803VRS4|||http://purl.uniprot.org/uniprot/A0A803W2U2|||http://purl.uniprot.org/uniprot/U3KGA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59894:UBE2E3 ^@ http://purl.uniprot.org/uniprot/U3JLL8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:KCNK10 ^@ http://purl.uniprot.org/uniprot/A0A803VWH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59894:PCNX4 ^@ http://purl.uniprot.org/uniprot/U3JLF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pecanex family.|||Membrane http://togogenome.org/gene/59894:SEPT2 ^@ http://purl.uniprot.org/uniprot/U3JLB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium membrane|||spindle http://togogenome.org/gene/59894:CPO ^@ http://purl.uniprot.org/uniprot/U3JN00 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:CENPJ ^@ http://purl.uniprot.org/uniprot/U3K288 ^@ Similarity ^@ Belongs to the TCP10 family. http://togogenome.org/gene/59894:GALNT3 ^@ http://purl.uniprot.org/uniprot/U3K142 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:CREM ^@ http://purl.uniprot.org/uniprot/U3JX35 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DPY19L4 ^@ http://purl.uniprot.org/uniprot/A0A803VF20|||http://purl.uniprot.org/uniprot/U3JSI4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/59894:AMPD3 ^@ http://purl.uniprot.org/uniprot/A0A803VKH8|||http://purl.uniprot.org/uniprot/U3JE37 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/59894:CORO1C ^@ http://purl.uniprot.org/uniprot/U3K2J6 ^@ Similarity ^@ Belongs to the WD repeat coronin family. http://togogenome.org/gene/59894:ETS2 ^@ http://purl.uniprot.org/uniprot/A0A803WEA1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus|||Transcription factor. http://togogenome.org/gene/59894:DLL1 ^@ http://purl.uniprot.org/uniprot/U3JKM5 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/59894:CDH7 ^@ http://purl.uniprot.org/uniprot/U3JVM3 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CNR2 ^@ http://purl.uniprot.org/uniprot/U3KIL6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:P2RY2 ^@ http://purl.uniprot.org/uniprot/U3KJD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NR2F2 ^@ http://purl.uniprot.org/uniprot/A0A803VIG7|||http://purl.uniprot.org/uniprot/U3K704 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:POU6F2 ^@ http://purl.uniprot.org/uniprot/A0A803W250|||http://purl.uniprot.org/uniprot/U3JRN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/59894:TEKT1 ^@ http://purl.uniprot.org/uniprot/U3JPZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tektin family.|||flagellum http://togogenome.org/gene/59894:PSME4 ^@ http://purl.uniprot.org/uniprot/U3KA06 ^@ Similarity ^@ Belongs to the BLM10 family. http://togogenome.org/gene/59894:MLST8 ^@ http://purl.uniprot.org/uniprot/U3JLW7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat LST8 family.|||Cytoplasm|||Part of TORC1 complex. Part of the TORC2 complex.|||Subunit of TORC1 and TORC2, which regulate cell growth and survival in response to nutrient and hormonal signals. http://togogenome.org/gene/59894:WARS2 ^@ http://purl.uniprot.org/uniprot/A0A803W5W2|||http://purl.uniprot.org/uniprot/U3JR28 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:NDST1 ^@ http://purl.uniprot.org/uniprot/A0A803VRE5|||http://purl.uniprot.org/uniprot/U3K019 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/59894:FOXN4 ^@ http://purl.uniprot.org/uniprot/U3K294 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:FAM135A ^@ http://purl.uniprot.org/uniprot/A0A803V3V4|||http://purl.uniprot.org/uniprot/A0A803W3I0|||http://purl.uniprot.org/uniprot/U3JWX4 ^@ Similarity ^@ Belongs to the FAM135 family. http://togogenome.org/gene/59894:MGAT5B ^@ http://purl.uniprot.org/uniprot/U3JDN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101806043 ^@ http://purl.uniprot.org/uniprot/U3KBN2 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59894:ORMDL1 ^@ http://purl.uniprot.org/uniprot/U3JP82 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/59894:PDE8A ^@ http://purl.uniprot.org/uniprot/A0A803VBC7|||http://purl.uniprot.org/uniprot/A0A803VP06 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:PTN ^@ http://purl.uniprot.org/uniprot/U3JCN8 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/59894:TNNT2 ^@ http://purl.uniprot.org/uniprot/U3JIL8 ^@ Function|||Similarity ^@ Belongs to the troponin T family.|||Troponin T is the tropomyosin-binding subunit of troponin, the thin filament regulatory complex which confers calcium-sensitivity to striated muscle actomyosin ATPase activity. http://togogenome.org/gene/59894:RNMT ^@ http://purl.uniprot.org/uniprot/U3JVF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. mRNA cap 0 methyltransferase family.|||In the N-terminal section; belongs to the dsDNA virus mRNA guanylyltransferase family.|||Nucleus http://togogenome.org/gene/59894:PRPS2 ^@ http://purl.uniprot.org/uniprot/A0A803W375 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/59894:TMEM144 ^@ http://purl.uniprot.org/uniprot/A0A803VPC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM144 family.|||Membrane http://togogenome.org/gene/59894:GRIA3 ^@ http://purl.uniprot.org/uniprot/A0A803VL73|||http://purl.uniprot.org/uniprot/A0A803WED9|||http://purl.uniprot.org/uniprot/U3JFN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:TMEM198 ^@ http://purl.uniprot.org/uniprot/U3JNX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM198 family.|||Membrane http://togogenome.org/gene/59894:MED24 ^@ http://purl.uniprot.org/uniprot/U3JCF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 24 family.|||Nucleus http://togogenome.org/gene/59894:ENPP2 ^@ http://purl.uniprot.org/uniprot/U3JI40 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Binds 1 Ca(2+) ion per subunit.|||Binds 2 Zn(2+) ions per subunit.|||Secreted http://togogenome.org/gene/59894:LOC101806839 ^@ http://purl.uniprot.org/uniprot/A0A803VHL9 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/59894:EAF2 ^@ http://purl.uniprot.org/uniprot/U3KFP4 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/59894:CDK8 ^@ http://purl.uniprot.org/uniprot/A0A803VVQ2|||http://purl.uniprot.org/uniprot/U3K1X5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:P2RY1 ^@ http://purl.uniprot.org/uniprot/U3KJA5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NXPH1 ^@ http://purl.uniprot.org/uniprot/A0A803WBT5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexophilin family.|||May be signaling molecules that resemble neuropeptides.|||Secreted http://togogenome.org/gene/59894:STX7 ^@ http://purl.uniprot.org/uniprot/U3KBB5 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:LOC101818745 ^@ http://purl.uniprot.org/uniprot/A0A803VGZ9 ^@ Similarity ^@ Belongs to the PWWP3A family. http://togogenome.org/gene/59894:KIF13A ^@ http://purl.uniprot.org/uniprot/U3KGB9 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:NLGN4X ^@ http://purl.uniprot.org/uniprot/A0A803VEX7|||http://purl.uniprot.org/uniprot/U3JPR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PPP4R3A ^@ http://purl.uniprot.org/uniprot/A0A803W5D2|||http://purl.uniprot.org/uniprot/U3JI61 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/59894:CABIN1 ^@ http://purl.uniprot.org/uniprot/A0A803VUD3|||http://purl.uniprot.org/uniprot/U3JXQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MYO1B ^@ http://purl.uniprot.org/uniprot/U3JP22 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:TRPC5 ^@ http://purl.uniprot.org/uniprot/U3K920 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CHST10 ^@ http://purl.uniprot.org/uniprot/U3JMM2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:CLTB ^@ http://purl.uniprot.org/uniprot/U3K1N0|||http://purl.uniprot.org/uniprot/U3K1N2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the clathrin light chain family.|||Clathrin is the major protein of the polyhedral coat of coated pits and vesicles.|||Cytoplasmic vesicle membrane|||coated pit http://togogenome.org/gene/59894:TMSB4X ^@ http://purl.uniprot.org/uniprot/A0A803W5X2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the thymosin beta family.|||Plays an important role in the organization of the cytoskeleton. Binds to and sequesters actin monomers (G actin) and therefore inhibits actin polymerization.|||cytoskeleton http://togogenome.org/gene/59894:LMX1B ^@ http://purl.uniprot.org/uniprot/U3JHQ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:NME7 ^@ http://purl.uniprot.org/uniprot/A0A803VAE1|||http://purl.uniprot.org/uniprot/A0A803VJH1|||http://purl.uniprot.org/uniprot/U3JT81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NDK family.|||cilium axoneme http://togogenome.org/gene/59894:HYOU1 ^@ http://purl.uniprot.org/uniprot/U3K5I9 ^@ Similarity ^@ Belongs to the heat shock protein 70 family. http://togogenome.org/gene/59894:DRD1 ^@ http://purl.uniprot.org/uniprot/U3KJ18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TLR7 ^@ http://purl.uniprot.org/uniprot/U3JPF7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Endoplasmic reticulum membrane|||Lysosome|||Membrane|||phagosome http://togogenome.org/gene/59894:TARS ^@ http://purl.uniprot.org/uniprot/U3JHG2 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:SH3BGRL3 ^@ http://purl.uniprot.org/uniprot/U3JC89 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/59894:DTX2 ^@ http://purl.uniprot.org/uniprot/U3K4M3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Deltex family.|||Cytoplasm http://togogenome.org/gene/59894:RPL7 ^@ http://purl.uniprot.org/uniprot/U3K1K7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/59894:TJAP1 ^@ http://purl.uniprot.org/uniprot/U3KC49 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MOGAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VWV1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GMPPA ^@ http://purl.uniprot.org/uniprot/A0A803VVI1|||http://purl.uniprot.org/uniprot/U3JNW3 ^@ Similarity ^@ Belongs to the transferase hexapeptide repeat family. http://togogenome.org/gene/59894:NMNAT1 ^@ http://purl.uniprot.org/uniprot/A0A803WDU1 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/59894:ATP6V1C2 ^@ http://purl.uniprot.org/uniprot/A0A803W645|||http://purl.uniprot.org/uniprot/U3JW02 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/59894:FUBP1 ^@ http://purl.uniprot.org/uniprot/A0A803VCV6|||http://purl.uniprot.org/uniprot/A0A803WCG4|||http://purl.uniprot.org/uniprot/U3JTA4 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:GDF15 ^@ http://purl.uniprot.org/uniprot/U3K498 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/59894:MYOD1 ^@ http://purl.uniprot.org/uniprot/U3JDC7 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/59894:MARCO ^@ http://purl.uniprot.org/uniprot/U3KGT2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:CTSC ^@ http://purl.uniprot.org/uniprot/U3JZI7 ^@ Similarity|||Subunit ^@ Belongs to the peptidase C1 family.|||Tetramer of heterotrimers consisting of exclusion domain, heavy- and light chains. http://togogenome.org/gene/59894:SLA ^@ http://purl.uniprot.org/uniprot/A0A803VEZ4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ACLY ^@ http://purl.uniprot.org/uniprot/A0A803VV09 ^@ Function|||Similarity|||Subunit ^@ Catalyzes the cleavage of citrate into oxaloacetate and acetyl-CoA, the latter serving as common substrate for de novo cholesterol and fatty acid synthesis.|||Homotetramer.|||In the C-terminal section; belongs to the succinate/malate CoA ligase alpha subunit family.|||In the N-terminal section; belongs to the succinate/malate CoA ligase beta subunit family. http://togogenome.org/gene/59894:SDHD ^@ http://purl.uniprot.org/uniprot/U3JUL4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CybS family.|||Component of complex II composed of four subunits: the flavoprotein (FP) SDHA, iron-sulfur protein (IP) SDHB, and a cytochrome b560 composed of SDHC and SDHD.|||Membrane|||Membrane-anchoring subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/59894:INIP ^@ http://purl.uniprot.org/uniprot/A0A803VLE6|||http://purl.uniprot.org/uniprot/U3JBH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SOSS-C family.|||Component of the SOSS complex, a multiprotein complex that functions downstream of the MRN complex to promote DNA repair and G2/M checkpoint. The SOSS complex associates with single-stranded DNA at DNA lesions and influences diverse endpoints in the cellular DNA damage response including cell-cycle checkpoint activation, recombinational repair and maintenance of genomic stability. Required for efficient homologous recombination-dependent repair of double-strand breaks (DSBs).|||Component of the SOSS complex.|||Nucleus http://togogenome.org/gene/59894:TIE1 ^@ http://purl.uniprot.org/uniprot/U3JSW5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PTGFR ^@ http://purl.uniprot.org/uniprot/A0A803V7K6|||http://purl.uniprot.org/uniprot/A0A803VYS2 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:TVP23B ^@ http://purl.uniprot.org/uniprot/U3K4G5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TVP23 family.|||Membrane http://togogenome.org/gene/59894:TEK ^@ http://purl.uniprot.org/uniprot/U3JY02 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101821137 ^@ http://purl.uniprot.org/uniprot/U3KB34 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:AQP9 ^@ http://purl.uniprot.org/uniprot/A0A803W925 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/59894:TMTC3 ^@ http://purl.uniprot.org/uniprot/U3K7T4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMTC family.|||Endoplasmic reticulum|||Membrane http://togogenome.org/gene/59894:MFGE8 ^@ http://purl.uniprot.org/uniprot/U3K7A9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:RAE1 ^@ http://purl.uniprot.org/uniprot/U3K8C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat rae1 family.|||spindle pole http://togogenome.org/gene/59894:PSMG1 ^@ http://purl.uniprot.org/uniprot/U3JR57 ^@ Similarity ^@ Belongs to the PSMG1 family. http://togogenome.org/gene/59894:LOC101816892 ^@ http://purl.uniprot.org/uniprot/A0A803WE52 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/59894:STXBP5L ^@ http://purl.uniprot.org/uniprot/A0A803VBT1|||http://purl.uniprot.org/uniprot/A0A803VKW4|||http://purl.uniprot.org/uniprot/A0A803WED3|||http://purl.uniprot.org/uniprot/U3JRU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat L(2)GL family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:LOC101810290 ^@ http://purl.uniprot.org/uniprot/U3KE68 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/59894:LOC101815188 ^@ http://purl.uniprot.org/uniprot/A0A803VSY4|||http://purl.uniprot.org/uniprot/U3K719 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/59894:NDUFS1 ^@ http://purl.uniprot.org/uniprot/U3JMN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I 75 kDa subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:WWOX ^@ http://purl.uniprot.org/uniprot/U3JWJ1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:PHKA1 ^@ http://purl.uniprot.org/uniprot/U3KBV4 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Although the final Cys may be farnesylated, the terminal tripeptide is probably not removed, and the C-terminus is not methylated.|||Belongs to the phosphorylase b kinase regulatory chain family.|||Cell membrane|||Membrane|||Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The alpha chain may bind calmodulin. http://togogenome.org/gene/59894:TADA2A ^@ http://purl.uniprot.org/uniprot/U3JRP3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101814982 ^@ http://purl.uniprot.org/uniprot/U3JZM4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:KCNF1 ^@ http://purl.uniprot.org/uniprot/U3KJN8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:KIAA1191 ^@ http://purl.uniprot.org/uniprot/U3K1L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the P33MONOX family.|||Cytoplasm http://togogenome.org/gene/59894:ETV4 ^@ http://purl.uniprot.org/uniprot/A0A803W9B3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:CLPS ^@ http://purl.uniprot.org/uniprot/U3JLU0 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Colipase is a cofactor of pancreatic lipase. It allows the lipase to anchor itself to the lipid-water interface. Without colipase the enzyme is washed off by bile salts, which have an inhibitory effect on the lipase.|||Enterostatin has a biological activity as a satiety signal.|||Forms a 1:1 stoichiometric complex with pancreatic lipase.|||Secreted http://togogenome.org/gene/59894:LOC101807707 ^@ http://purl.uniprot.org/uniprot/A0A803VIB9|||http://purl.uniprot.org/uniprot/U3KHN7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:AP1S3 ^@ http://purl.uniprot.org/uniprot/A0A803VWA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes small subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus|||clathrin-coated pit http://togogenome.org/gene/59894:STAG2 ^@ http://purl.uniprot.org/uniprot/A0A803V0E6|||http://purl.uniprot.org/uniprot/A0A803V9Y5|||http://purl.uniprot.org/uniprot/U3JFL5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SCC3 family.|||Chromosome|||Component of cohesin complex, a complex required for the cohesion of sister chromatids after DNA replication. The cohesin complex apparently forms a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate.|||Nucleus|||Part of the cohesin complex which is composed of a heterodimer between a SMC1 protein (SMC1A or SMC1B) and SMC3, which are attached via their hinge domain, and RAD21 which link them at their heads, and one STAG protein.|||centromere http://togogenome.org/gene/59894:ANXA5 ^@ http://purl.uniprot.org/uniprot/A0A803VDW6|||http://purl.uniprot.org/uniprot/U3K0Y8 ^@ Domain|||Similarity ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family. http://togogenome.org/gene/59894:STRIP2 ^@ http://purl.uniprot.org/uniprot/U3JQU0 ^@ Similarity ^@ Belongs to the STRIP family. http://togogenome.org/gene/59894:RPL12 ^@ http://purl.uniprot.org/uniprot/U3JSD6 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uL11 family.|||Binds directly to 26S ribosomal RNA. http://togogenome.org/gene/59894:BRINP3 ^@ http://purl.uniprot.org/uniprot/U3JL82 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/59894:POLR2B ^@ http://purl.uniprot.org/uniprot/U3JTT7 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/59894:FOXN2 ^@ http://purl.uniprot.org/uniprot/A0A803V0J5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SGSM1 ^@ http://purl.uniprot.org/uniprot/U3K1V7 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/59894:MED7 ^@ http://purl.uniprot.org/uniprot/U3KIZ0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 7 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59894:LOC101816865 ^@ http://purl.uniprot.org/uniprot/U3JDQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/59894:CD82 ^@ http://purl.uniprot.org/uniprot/U3KCS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:MPP7 ^@ http://purl.uniprot.org/uniprot/A0A803VCX2|||http://purl.uniprot.org/uniprot/U3JXF2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||adherens junction|||tight junction http://togogenome.org/gene/59894:POLRMT ^@ http://purl.uniprot.org/uniprot/A0A803VZM2 ^@ Function|||Similarity ^@ Belongs to the phage and mitochondrial RNA polymerase family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/59894:FBLN5 ^@ http://purl.uniprot.org/uniprot/A0A803W0V0 ^@ Caution|||Similarity ^@ Belongs to the fibulin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:PSPH ^@ http://purl.uniprot.org/uniprot/U3JWC0 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. SerB family. http://togogenome.org/gene/59894:TMEM233 ^@ http://purl.uniprot.org/uniprot/A0A803VSG9 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:NAA35 ^@ http://purl.uniprot.org/uniprot/U3JLU4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the MAK10 family.|||Component of the N-terminal acetyltransferase C (NatC) complex, which is composed of NAA35, NAA38 and NAA30.|||Cytoplasm http://togogenome.org/gene/59894:CDC20 ^@ http://purl.uniprot.org/uniprot/U3JST6 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/59894:LOC101813169 ^@ http://purl.uniprot.org/uniprot/A0A803VK03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c-type heme lyase family.|||Lyase that catalyzes the covalent linking of the heme group to the cytochrome C apoprotein to produce the mature functional cytochrome.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:TMEM200A ^@ http://purl.uniprot.org/uniprot/U3KLM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM200 family.|||Membrane http://togogenome.org/gene/59894:PPM1B ^@ http://purl.uniprot.org/uniprot/A0A803VK77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/59894:LOC101813838 ^@ http://purl.uniprot.org/uniprot/U3JZ90 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:TMEM63B ^@ http://purl.uniprot.org/uniprot/A0A803WGK1|||http://purl.uniprot.org/uniprot/U3K9U7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/59894:BMP5 ^@ http://purl.uniprot.org/uniprot/U3JGJ4 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/59894:NCL ^@ http://purl.uniprot.org/uniprot/U3JYT3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:GPM6A ^@ http://purl.uniprot.org/uniprot/A0A803WGN4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/59894:LOC101817197 ^@ http://purl.uniprot.org/uniprot/A0A803VNI5 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/59894:NAPG ^@ http://purl.uniprot.org/uniprot/A0A803VAS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP family.|||Membrane|||Required for vesicular transport between the endoplasmic reticulum and the Golgi apparatus. http://togogenome.org/gene/59894:LARS2 ^@ http://purl.uniprot.org/uniprot/U3JIX2 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:THRSP ^@ http://purl.uniprot.org/uniprot/U3KKR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPOT14 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CD44 ^@ http://purl.uniprot.org/uniprot/A0A803V1V8|||http://purl.uniprot.org/uniprot/A0A803VZB8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||microvillus http://togogenome.org/gene/59894:HDAC2 ^@ http://purl.uniprot.org/uniprot/U3K8U9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes.|||Nucleus http://togogenome.org/gene/59894:STX19 ^@ http://purl.uniprot.org/uniprot/U3KK39 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:SERPINF1 ^@ http://purl.uniprot.org/uniprot/U3JVT3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:ANO3 ^@ http://purl.uniprot.org/uniprot/U3JK59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Membrane http://togogenome.org/gene/59894:GPD2 ^@ http://purl.uniprot.org/uniprot/U3JK58 ^@ Function|||Similarity ^@ Belongs to the FAD-dependent glycerol-3-phosphate dehydrogenase family.|||Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. http://togogenome.org/gene/59894:FMR1 ^@ http://purl.uniprot.org/uniprot/U3KC61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMR1 family.|||Cell membrane|||Cytoplasmic ribonucleoprotein granule|||Membrane|||Perikaryon|||Presynaptic cell membrane|||Synaptic cell membrane|||axon|||centromere|||dendrite|||dendritic spine|||filopodium tip|||growth cone|||neuron projection|||nucleolus|||perinuclear region|||synaptosome http://togogenome.org/gene/59894:RNF152 ^@ http://purl.uniprot.org/uniprot/U3KK12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNF152 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:COPB2 ^@ http://purl.uniprot.org/uniprot/U3JNA8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat COPB2 family.|||COPI-coated vesicle membrane|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. In mammals, the coatomer can only be recruited by membranes associated to ADP-ribosylation factors (ARFs), which are small GTP-binding proteins; the complex also influences the Golgi structural integrity, as well as the processing, activity, and endocytic recycling of LDL receptors.|||This coatomer complex protein, essential for Golgi budding and vesicular trafficking, is a selective binding protein (RACK) for protein kinase C, epsilon type. It binds to Golgi membranes in a GTP-dependent manner. http://togogenome.org/gene/59894:SPDEF ^@ http://purl.uniprot.org/uniprot/A0A803VH15|||http://purl.uniprot.org/uniprot/U3JMC4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Nucleus|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/59894:GINS1 ^@ http://purl.uniprot.org/uniprot/A0A803W5N9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS1/PSF1 family.|||Chromosome|||Component of the GINS complex.|||Nucleus|||Required for correct functioning of the GINS complex, a complex that plays an essential role in the initiation of DNA replication, and progression of DNA replication forks. GINS complex seems to bind preferentially to single-stranded DNA. http://togogenome.org/gene/59894:LOC101817870 ^@ http://purl.uniprot.org/uniprot/U3JZB6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:GSTK1 ^@ http://purl.uniprot.org/uniprot/A0A803V7L8 ^@ Similarity ^@ Belongs to the GST superfamily. Kappa family. http://togogenome.org/gene/59894:AHSA2 ^@ http://purl.uniprot.org/uniprot/U3K900 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/59894:PRPSAP2 ^@ http://purl.uniprot.org/uniprot/U3KGZ7 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/59894:NIM1K ^@ http://purl.uniprot.org/uniprot/U3K9C0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:SPPL2B ^@ http://purl.uniprot.org/uniprot/U3KBS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:SGMS1 ^@ http://purl.uniprot.org/uniprot/A0A803W881 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/59894:FUT10 ^@ http://purl.uniprot.org/uniprot/U3JRC3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane|||Probable fucosyltransferase. http://togogenome.org/gene/59894:SYT1 ^@ http://purl.uniprot.org/uniprot/U3K7D1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptotagmin family.|||Binds 3 Ca(2+) ions per subunit. The ions are bound to the C2 domains.|||May have a regulatory role in the membrane interactions during trafficking of synaptic vesicles at the active zone of the synapse. It binds acidic phospholipids with a specificity that requires the presence of both an acidic head group and a diacyl backbone.|||Membrane|||chromaffin granule membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:SLC7A6 ^@ http://purl.uniprot.org/uniprot/A0A803VD81|||http://purl.uniprot.org/uniprot/U3JZ22 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PDE9A ^@ http://purl.uniprot.org/uniprot/A0A803V0T5|||http://purl.uniprot.org/uniprot/A0A803V194|||http://purl.uniprot.org/uniprot/U3JGY9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:C3H6orf58 ^@ http://purl.uniprot.org/uniprot/U3KAH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LEG1 family.|||Secreted http://togogenome.org/gene/59894:CC2D1B ^@ http://purl.uniprot.org/uniprot/U3JSQ5 ^@ Similarity ^@ Belongs to the CC2D1 family. http://togogenome.org/gene/59894:LECT2 ^@ http://purl.uniprot.org/uniprot/U3K007 ^@ Similarity ^@ Belongs to the LECT2/MIM-1 family. http://togogenome.org/gene/59894:CCNI ^@ http://purl.uniprot.org/uniprot/U3K1G0 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59894:RNASET2 ^@ http://purl.uniprot.org/uniprot/A0A803VPZ4|||http://purl.uniprot.org/uniprot/U3KCU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RNase T2 family.|||Lysosome lumen http://togogenome.org/gene/59894:MRPL41 ^@ http://purl.uniprot.org/uniprot/U3KJZ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL41 family.|||Mitochondrion http://togogenome.org/gene/59894:RAB3GAP1 ^@ http://purl.uniprot.org/uniprot/A0A803WBT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Rab3-GAP catalytic subunit family.|||Cytoplasm http://togogenome.org/gene/59894:PRMT7 ^@ http://purl.uniprot.org/uniprot/U3JZ49 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Arginine methyltransferase that can both catalyze the formation of omega-N monomethylarginine (MMA) and symmetrical dimethylarginine (sDMA), with a preference for the formation of MMA. Specifically mediates the symmetrical dimethylation of arginine residues in the small nuclear ribonucleoproteins Sm D1 (SNRPD1) and Sm D3 (SNRPD3); such methylation being required for the assembly and biogenesis of snRNP core particles. Specifically mediates the symmetric dimethylation of histone H4 'Arg-3' to form H4R3me2s. Plays a role in gene imprinting by being recruited by CTCFL at the H19 imprinted control region (ICR) and methylating histone H4 to form H4R3me2s, possibly leading to recruit DNA methyltransferases at these sites. May also play a role in embryonic stem cell (ESC) pluripotency. Also able to mediate the arginine methylation of histone H2A and myelin basic protein (MBP) in vitro; the relevance of such results is however unclear in vivo.|||Belongs to the class I-like SAM-binding methyltransferase superfamily. Protein arginine N-methyltransferase family. PRMT7 subfamily.|||Nucleus|||cytosol http://togogenome.org/gene/59894:MOSPD1 ^@ http://purl.uniprot.org/uniprot/A0A803VDK7|||http://purl.uniprot.org/uniprot/A0A803VWT0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:MKNK1 ^@ http://purl.uniprot.org/uniprot/U3K423 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:CD247 ^@ http://purl.uniprot.org/uniprot/A0A803W4N3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CD3Z/FCER1G family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:COG4 ^@ http://purl.uniprot.org/uniprot/U3JY46 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG4 family.|||Golgi apparatus membrane http://togogenome.org/gene/59894:PELI2 ^@ http://purl.uniprot.org/uniprot/A0A803VVS7|||http://purl.uniprot.org/uniprot/U3JM71 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/59894:KCNV2 ^@ http://purl.uniprot.org/uniprot/U3K7F7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:UBIAD1 ^@ http://purl.uniprot.org/uniprot/A0A803WA05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Membrane http://togogenome.org/gene/59894:FICD ^@ http://purl.uniprot.org/uniprot/U3K2P1 ^@ Similarity ^@ Belongs to the fic family. http://togogenome.org/gene/59894:TRAF5 ^@ http://purl.uniprot.org/uniprot/U3KDG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TNF receptor-associated factor family.|||Cytoplasm http://togogenome.org/gene/59894:LOC101809643 ^@ http://purl.uniprot.org/uniprot/U3JU74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/59894:SDC1 ^@ http://purl.uniprot.org/uniprot/U3JGE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the syndecan proteoglycan family.|||Cell surface proteoglycan.|||Membrane|||extracellular exosome http://togogenome.org/gene/59894:SRPX ^@ http://purl.uniprot.org/uniprot/A0A803VHJ1|||http://purl.uniprot.org/uniprot/U3JFU9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:STX17 ^@ http://purl.uniprot.org/uniprot/A0A803W6Y4 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:HOOK1 ^@ http://purl.uniprot.org/uniprot/A0A803W6D2|||http://purl.uniprot.org/uniprot/U3KD55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the hook family.|||cytoskeleton http://togogenome.org/gene/59894:NTMT1 ^@ http://purl.uniprot.org/uniprot/U3JFE0 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. NTM1 family. http://togogenome.org/gene/59894:ODF2L ^@ http://purl.uniprot.org/uniprot/U3JUU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/59894:LOC101820945 ^@ http://purl.uniprot.org/uniprot/A0A803V107 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/59894:EBF3 ^@ http://purl.uniprot.org/uniprot/U3JEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/59894:CEP170B ^@ http://purl.uniprot.org/uniprot/U3JJZ4 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/59894:TRPM2 ^@ http://purl.uniprot.org/uniprot/U3JKZ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM2 sub-subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CDH5 ^@ http://purl.uniprot.org/uniprot/U3JYU9 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell junction|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PFKFB3 ^@ http://purl.uniprot.org/uniprot/A0A803V952|||http://purl.uniprot.org/uniprot/U3JGG0 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/59894:GTF2A1 ^@ http://purl.uniprot.org/uniprot/U3KDF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFIIA subunit 1 family.|||Nucleus http://togogenome.org/gene/59894:TNR ^@ http://purl.uniprot.org/uniprot/U3K150 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family.|||extracellular matrix http://togogenome.org/gene/59894:TAF1 ^@ http://purl.uniprot.org/uniprot/A0A803VZP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF1 family.|||Nucleus http://togogenome.org/gene/59894:PAPSS1 ^@ http://purl.uniprot.org/uniprot/A0A803V140|||http://purl.uniprot.org/uniprot/U3KCX2 ^@ Similarity ^@ In the C-terminal section; belongs to the sulfate adenylyltransferase family.|||In the N-terminal section; belongs to the APS kinase family. http://togogenome.org/gene/59894:PLCZ1 ^@ http://purl.uniprot.org/uniprot/A0A803W8I2|||http://purl.uniprot.org/uniprot/U3JEC3 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. In vitro, hydrolyzes PtdIns(4,5)P2 in a Ca(2+)-dependent manner. Triggers intracellular Ca(2+) oscillations in oocytes solely during M phase and is involved in inducing oocyte activation and initiating embryonic development up to the blastocyst stage. Is therefore a strong candidate for the egg-activating soluble sperm factor that is transferred from the sperm into the egg cytoplasm following gamete membrane fusion. May exert an inhibitory effect on phospholipase-C-coupled processes that depend on calcium ions and protein kinase C, including CFTR trafficking and function.|||perinuclear region http://togogenome.org/gene/59894:DARS2 ^@ http://purl.uniprot.org/uniprot/U3JZX3 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Type 1 subfamily. http://togogenome.org/gene/59894:EZH1 ^@ http://purl.uniprot.org/uniprot/A0A803V4G2|||http://purl.uniprot.org/uniprot/U3JD86 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101805977 ^@ http://purl.uniprot.org/uniprot/U3JNR4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:EPHA6 ^@ http://purl.uniprot.org/uniprot/U3JG07 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LTV1 ^@ http://purl.uniprot.org/uniprot/U3KDX4 ^@ Similarity ^@ Belongs to the LTV1 family. http://togogenome.org/gene/59894:YWHAB ^@ http://purl.uniprot.org/uniprot/U3JS32 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:MTHFD1 ^@ http://purl.uniprot.org/uniprot/U3JKR6 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the formate--tetrahydrofolate ligase family.|||In the N-terminal section; belongs to the tetrahydrofolate dehydrogenase/cyclohydrolase family. http://togogenome.org/gene/59894:GALR2 ^@ http://purl.uniprot.org/uniprot/U3JE16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:MTNR1A ^@ http://purl.uniprot.org/uniprot/A0A803V2X6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CTDP1 ^@ http://purl.uniprot.org/uniprot/U3KFV6 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||This promotes the activity of RNA polymerase II. http://togogenome.org/gene/59894:LOC101818796 ^@ http://purl.uniprot.org/uniprot/U3JZ58 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/59894:PLP1 ^@ http://purl.uniprot.org/uniprot/A0A803W052 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/59894:FSCN1 ^@ http://purl.uniprot.org/uniprot/U3KHC3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fascin family.|||cytoskeleton http://togogenome.org/gene/59894:STAT3 ^@ http://purl.uniprot.org/uniprot/A0A803VXQ8|||http://purl.uniprot.org/uniprot/U3JD42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:DYNC1I1 ^@ http://purl.uniprot.org/uniprot/U3K6Q7 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/59894:CDH6 ^@ http://purl.uniprot.org/uniprot/U3KEA4 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ROS1 ^@ http://purl.uniprot.org/uniprot/U3K981 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/59894:CAPRIN2 ^@ http://purl.uniprot.org/uniprot/U3K323 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/59894:TCEANC ^@ http://purl.uniprot.org/uniprot/U3KL82 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SLC24A5 ^@ http://purl.uniprot.org/uniprot/U3KAN9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC24A subfamily.|||Membrane http://togogenome.org/gene/59894:STK11 ^@ http://purl.uniprot.org/uniprot/A0A803VF14|||http://purl.uniprot.org/uniprot/U3KHU8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. LKB1 subfamily. http://togogenome.org/gene/59894:MCOLN2 ^@ http://purl.uniprot.org/uniprot/A0A803WE49|||http://purl.uniprot.org/uniprot/U3JUJ2 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/59894:GOLGA5 ^@ http://purl.uniprot.org/uniprot/A0A803VTZ1|||http://purl.uniprot.org/uniprot/U3JID4 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||Involved in maintaining Golgi structure. Stimulates the formation of Golgi stacks and ribbons. Involved in intra-Golgi retrograde transport.|||Membrane http://togogenome.org/gene/59894:LOC101817073 ^@ http://purl.uniprot.org/uniprot/A0A803WC23 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/59894:CAPN7 ^@ http://purl.uniprot.org/uniprot/U3K377 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59894:SH3BGRL ^@ http://purl.uniprot.org/uniprot/A0A803V1B7 ^@ Similarity ^@ Belongs to the SH3BGR family. http://togogenome.org/gene/59894:LOC101816390 ^@ http://purl.uniprot.org/uniprot/A0A803VJU1|||http://purl.uniprot.org/uniprot/A0A803W8X8|||http://purl.uniprot.org/uniprot/U3JZW1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/59894:LOC101816519 ^@ http://purl.uniprot.org/uniprot/U3K5U9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the concentrative nucleoside transporter (CNT) (TC 2.A.41) family.|||Membrane http://togogenome.org/gene/59894:SLC4A11 ^@ http://purl.uniprot.org/uniprot/A0A803VEU8|||http://purl.uniprot.org/uniprot/A0A803VEY0|||http://purl.uniprot.org/uniprot/A0A803WF64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/59894:VWC2L ^@ http://purl.uniprot.org/uniprot/A0A803W4N2 ^@ Subcellular Location Annotation ^@ Synapse http://togogenome.org/gene/59894:LOC101819070 ^@ http://purl.uniprot.org/uniprot/U3KB25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59894:KIF12 ^@ http://purl.uniprot.org/uniprot/U3JVG6 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:HTR1B ^@ http://purl.uniprot.org/uniprot/U3KJS0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Homodimer. Heterodimer with HTR1D.|||Membrane http://togogenome.org/gene/59894:FAM163A ^@ http://purl.uniprot.org/uniprot/U3K0D0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM163 family.|||Membrane http://togogenome.org/gene/59894:GCM2 ^@ http://purl.uniprot.org/uniprot/U3KFX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:HS6ST1 ^@ http://purl.uniprot.org/uniprot/U3JLP5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ 6-O-sulfation enzyme which catalyzes the transfer of sulfate from 3'-phosphoadenosine 5'-phosphosulfate (PAPS) to position 6 of the N-sulfoglucosamine residue (GlcNS) of heparan sulfate.|||Belongs to the sulfotransferase 6 family.|||Membrane http://togogenome.org/gene/59894:DUS3L ^@ http://purl.uniprot.org/uniprot/U3JF48 ^@ Similarity ^@ Belongs to the dus family. Dus3 subfamily. http://togogenome.org/gene/59894:SCD ^@ http://purl.uniprot.org/uniprot/U3JY31 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family.|||Membrane|||The histidine box domains are involved in binding the catalytic metal ions. http://togogenome.org/gene/59894:LOC101808210 ^@ http://purl.uniprot.org/uniprot/A0A803VD77 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the intercrine alpha (chemokine CxC) family.|||Homodimer.|||Secreted http://togogenome.org/gene/59894:MMP7 ^@ http://purl.uniprot.org/uniprot/U3JC75 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/59894:CDH3 ^@ http://purl.uniprot.org/uniprot/U3JK13 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:RAMP3 ^@ http://purl.uniprot.org/uniprot/U3KFJ4 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/59894:EAF1 ^@ http://purl.uniprot.org/uniprot/U3K388 ^@ Similarity ^@ Belongs to the EAF family. http://togogenome.org/gene/59894:LOC101809715 ^@ http://purl.uniprot.org/uniprot/U3JMQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:THRB ^@ http://purl.uniprot.org/uniprot/U3K3J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/59894:SUMF2 ^@ http://purl.uniprot.org/uniprot/U3JWB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfatase-modifying factor family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:CD34 ^@ http://purl.uniprot.org/uniprot/U3JCN4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101820470 ^@ http://purl.uniprot.org/uniprot/U3KAH0 ^@ Similarity ^@ Belongs to the COX20 family. http://togogenome.org/gene/59894:ENTPD6 ^@ http://purl.uniprot.org/uniprot/U3JDA9 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:MFSD7 ^@ http://purl.uniprot.org/uniprot/U3JE46 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:HTR2B ^@ http://purl.uniprot.org/uniprot/U3JYN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||synaptosome http://togogenome.org/gene/59894:FGD3 ^@ http://purl.uniprot.org/uniprot/A0A803V3B1 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:CCZ1 ^@ http://purl.uniprot.org/uniprot/A0A803V1X1|||http://purl.uniprot.org/uniprot/U3KHS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCZ1 family.|||Lysosome membrane http://togogenome.org/gene/59894:LOC101809392 ^@ http://purl.uniprot.org/uniprot/A0A803VHN6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:STAT6 ^@ http://purl.uniprot.org/uniprot/U3JC79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CALB2 ^@ http://purl.uniprot.org/uniprot/U3JXW7 ^@ Function|||Similarity ^@ Belongs to the calbindin family.|||Calretinin is a calcium-binding protein which is abundant in auditory neurons. http://togogenome.org/gene/59894:AMIGO2 ^@ http://purl.uniprot.org/uniprot/U3KKZ7 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/59894:ST6GALNAC1 ^@ http://purl.uniprot.org/uniprot/U3JDU9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:AKAP2 ^@ http://purl.uniprot.org/uniprot/U3JBG7 ^@ Similarity ^@ Belongs to the paralemmin family. http://togogenome.org/gene/59894:ND4L ^@ http://purl.uniprot.org/uniprot/S0AT24 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4L family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:AMER3 ^@ http://purl.uniprot.org/uniprot/U3KJE0 ^@ Similarity ^@ Belongs to the Amer family. http://togogenome.org/gene/59894:LOC101817781 ^@ http://purl.uniprot.org/uniprot/U3KDP9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:BANP ^@ http://purl.uniprot.org/uniprot/A0A803V551 ^@ Similarity ^@ Belongs to the BANP/SMAR1 family. http://togogenome.org/gene/59894:MTMR4 ^@ http://purl.uniprot.org/uniprot/U3KH59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:NDUFS7 ^@ http://purl.uniprot.org/uniprot/A0A803VSQ6 ^@ Similarity ^@ Belongs to the complex I 20 kDa subunit family. http://togogenome.org/gene/59894:LOC101808127 ^@ http://purl.uniprot.org/uniprot/U3JMF5 ^@ Subcellular Location Annotation ^@ acrosome http://togogenome.org/gene/59894:LOC101818267 ^@ http://purl.uniprot.org/uniprot/A0A803VII2|||http://purl.uniprot.org/uniprot/U3JLW2 ^@ Similarity ^@ Belongs to the DDI1 family. http://togogenome.org/gene/59894:LOC101806376 ^@ http://purl.uniprot.org/uniprot/U3JXK0 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:THADA ^@ http://purl.uniprot.org/uniprot/U3KDZ0 ^@ Similarity ^@ Belongs to the THADA family. http://togogenome.org/gene/59894:TEC ^@ http://purl.uniprot.org/uniprot/U3JKF9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:WNT11 ^@ http://purl.uniprot.org/uniprot/U3JUN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:GABARAPL1 ^@ http://purl.uniprot.org/uniprot/U3JLZ6 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59894:UGGT2 ^@ http://purl.uniprot.org/uniprot/U3JPD2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:CAMK2G ^@ http://purl.uniprot.org/uniprot/A0A803V6D0|||http://purl.uniprot.org/uniprot/A0A803VGD2|||http://purl.uniprot.org/uniprot/A0A803VLU5|||http://purl.uniprot.org/uniprot/A0A803VVM7|||http://purl.uniprot.org/uniprot/A0A803WCD9|||http://purl.uniprot.org/uniprot/U3JX42 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/59894:LOC101812892 ^@ http://purl.uniprot.org/uniprot/U3KBT4 ^@ Activity Regulation|||Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Converted into plasmin by plasminogen activators, both plasminogen and its activator being bound to fibrin.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invasion may be modulated by CSPG4. Binds to cells.|||Secreted http://togogenome.org/gene/59894:LOC101809058 ^@ http://purl.uniprot.org/uniprot/A0A803VFI5 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:LOC101809834 ^@ http://purl.uniprot.org/uniprot/U3JC04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:CAV3 ^@ http://purl.uniprot.org/uniprot/A0A803WE76 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the caveolin family.|||Cell membrane|||Golgi apparatus membrane|||May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity.|||Membrane|||caveola|||sarcolemma http://togogenome.org/gene/59894:LOXL4 ^@ http://purl.uniprot.org/uniprot/U3K0Z3 ^@ Caution|||Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the lysyl oxidase family.|||Contains 1 lysine tyrosylquinone.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the post-translational oxidative deamination of lysine residues on target proteins leading to the formation of deaminated lysine (allysine).|||The lysine tyrosylquinone cross-link (LTQ) is generated by condensation of the epsilon-amino group of a lysine with a topaquinone produced by oxidation of tyrosine.|||extracellular space http://togogenome.org/gene/59894:LOC101819841 ^@ http://purl.uniprot.org/uniprot/U3JR61 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/59894:ADAMTS6 ^@ http://purl.uniprot.org/uniprot/U3K566 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:LOC101821176 ^@ http://purl.uniprot.org/uniprot/U3JM30 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:FARS2 ^@ http://purl.uniprot.org/uniprot/U3KFE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Mitochondrion matrix http://togogenome.org/gene/59894:ELOVL7 ^@ http://purl.uniprot.org/uniprot/U3K915 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family. ELOVL7 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme with higher activity toward C18 acyl-CoAs, especially C18:3(n-3) acyl-CoAs and C18:3(n-6)-CoAs. Also active toward C20:4-, C18:0-, C18:1-, C18:2- and C16:0-CoAs, and weakly toward C20:0-CoA. Little or no activity toward C22:0-, C24:0-, or C26:0-CoAs. May participate to the production of saturated and polyunsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101819144 ^@ http://purl.uniprot.org/uniprot/U3KF04 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:SRP68 ^@ http://purl.uniprot.org/uniprot/U3JE18 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP68 family.|||Cytoplasm|||nucleolus http://togogenome.org/gene/59894:TPM3 ^@ http://purl.uniprot.org/uniprot/A0A803W3D6|||http://purl.uniprot.org/uniprot/U3JEM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59894:ARTN ^@ http://purl.uniprot.org/uniprot/U3JS69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/59894:MPI ^@ http://purl.uniprot.org/uniprot/U3K8I2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the mannose-6-phosphate isomerase type 1 family.|||Binds 1 zinc ion per subunit.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/59894:SUPV3L1 ^@ http://purl.uniprot.org/uniprot/U3KF77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family.|||mitochondrion nucleoid http://togogenome.org/gene/59894:SCAP ^@ http://purl.uniprot.org/uniprot/U3JHA8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SCAP family.|||COPII-coated vesicle membrane|||Golgi apparatus membrane http://togogenome.org/gene/59894:INO80 ^@ http://purl.uniprot.org/uniprot/U3JUD5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase component of the INO80 complex which remodels chromatin by shifting nucleosomes and is involved in DNA repair.|||Belongs to the SNF2/RAD54 helicase family.|||Component of the INO80 chromatin-remodeling complex.|||Nucleus|||The DBINO region is involved in binding to DNA. http://togogenome.org/gene/59894:AURKA ^@ http://purl.uniprot.org/uniprot/U3K8Q3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. Aurora subfamily.|||centrosome http://togogenome.org/gene/59894:LOC101816669 ^@ http://purl.uniprot.org/uniprot/U3K663 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the natriuretic peptide family.|||Secreted http://togogenome.org/gene/59894:LOC101815087 ^@ http://purl.uniprot.org/uniprot/U3JY85 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/59894:SLC26A1 ^@ http://purl.uniprot.org/uniprot/A0A803V7T3|||http://purl.uniprot.org/uniprot/A0A803VCU5|||http://purl.uniprot.org/uniprot/U3JRQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Mediates sulfate transport with high affinity. Mediates oxalate transport. Mediates bicarbonate transport. Does not accept succinate as cosubstrate.|||Membrane http://togogenome.org/gene/59894:LZIC ^@ http://purl.uniprot.org/uniprot/A0A803VWG3 ^@ Similarity ^@ Belongs to the CTNNBIP1 family. http://togogenome.org/gene/59894:CUBN ^@ http://purl.uniprot.org/uniprot/U3JYD5 ^@ Caution|||Subcellular Location Annotation ^@ Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:GNG4 ^@ http://purl.uniprot.org/uniprot/U3KGE2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/59894:OAT ^@ http://purl.uniprot.org/uniprot/U3JQB9 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59894:SESN3 ^@ http://purl.uniprot.org/uniprot/U3JC37 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/59894:PDCD11 ^@ http://purl.uniprot.org/uniprot/U3K2A0 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:RBBP7 ^@ http://purl.uniprot.org/uniprot/U3JP07 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:BAIAP2 ^@ http://purl.uniprot.org/uniprot/U3KDM8 ^@ Function|||Subcellular Location Annotation ^@ Adapter protein that links membrane-bound small G-proteins to cytoplasmic effector proteins. Necessary for CDC42-mediated reorganization of the actin cytoskeleton and for RAC1-mediated membrane ruffling. Involved in the regulation of the actin cytoskeleton by WASF family members and the Arp2/3 complex. Plays a role in neurite growth. Acts syngeristically with ENAH to promote filipodia formation. Plays a role in the reorganization of the actin cytoskeleton in response to bacterial infection. Participates in actin bundling when associated with EPS8, promoting filopodial protrusions.|||Membrane|||cytoskeleton|||filopodium|||ruffle http://togogenome.org/gene/59894:TMEM231 ^@ http://purl.uniprot.org/uniprot/A0A803WCF7|||http://purl.uniprot.org/uniprot/U3JIL0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM231 family.|||Membrane|||Transmembrane component of the tectonic-like complex, a complex localized at the transition zone of primary cilia and acting as a barrier that prevents diffusion of transmembrane proteins between the cilia and plasma membranes. Required for ciliogenesis and sonic hedgehog/SHH signaling.|||cilium membrane http://togogenome.org/gene/59894:DCT ^@ http://purl.uniprot.org/uniprot/U3JPL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/59894:ZCCHC17 ^@ http://purl.uniprot.org/uniprot/A0A803V4H8|||http://purl.uniprot.org/uniprot/U3JEL3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:MMD2 ^@ http://purl.uniprot.org/uniprot/U3KHD6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59894:CEP63 ^@ http://purl.uniprot.org/uniprot/U3KG37 ^@ Similarity ^@ Belongs to the CEP63 family. http://togogenome.org/gene/59894:LOC101818345 ^@ http://purl.uniprot.org/uniprot/U3JEI8 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/59894:GALNT16 ^@ http://purl.uniprot.org/uniprot/A0A803W8W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:CHCHD4 ^@ http://purl.uniprot.org/uniprot/A0A803W6V6 ^@ Subcellular Location Annotation ^@ Mitochondrion intermembrane space http://togogenome.org/gene/59894:CDC123 ^@ http://purl.uniprot.org/uniprot/A0A803V3J9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC123 family.|||Cytoplasm|||Required for S phase entry of the cell cycle. http://togogenome.org/gene/59894:SLC16A4 ^@ http://purl.uniprot.org/uniprot/U3JK95 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101817780 ^@ http://purl.uniprot.org/uniprot/U3KAR6 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:MFSD14A ^@ http://purl.uniprot.org/uniprot/A0A803VPM0|||http://purl.uniprot.org/uniprot/U3JIA4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/59894:ZHX3 ^@ http://purl.uniprot.org/uniprot/U3JSP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/59894:AHR ^@ http://purl.uniprot.org/uniprot/U3K5M4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:CNOT2 ^@ http://purl.uniprot.org/uniprot/U3K6N4 ^@ Similarity ^@ Belongs to the CNOT2/3/5 family. http://togogenome.org/gene/59894:FAM45A ^@ http://purl.uniprot.org/uniprot/U3JHM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND10 family.|||Endosome|||Late endosome http://togogenome.org/gene/59894:GPAM ^@ http://purl.uniprot.org/uniprot/U3JHW0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Esterifies acyl-group from acyl-ACP to the sn-1 position of glycerol-3-phosphate, an essential step in glycerolipids biosynthesis such as triglycerides, phosphatidic acids and lysophosphatidic acids.|||Mitochondrion outer membrane http://togogenome.org/gene/59894:TBK1 ^@ http://purl.uniprot.org/uniprot/U3K5R8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:STK3 ^@ http://purl.uniprot.org/uniprot/A0A803VAC8|||http://purl.uniprot.org/uniprot/U3JT63 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/59894:ARHGEF3 ^@ http://purl.uniprot.org/uniprot/A0A803VX28|||http://purl.uniprot.org/uniprot/A0A803WG95|||http://purl.uniprot.org/uniprot/U3K1I1 ^@ Function|||Subcellular Location Annotation ^@ Acts as guanine nucleotide exchange factor (GEF) for RhoA and RhoB GTPases.|||Cytoplasm http://togogenome.org/gene/59894:CCDC39 ^@ http://purl.uniprot.org/uniprot/U3K0V7 ^@ Similarity ^@ Belongs to the CCDC39 family. http://togogenome.org/gene/59894:CLSTN3 ^@ http://purl.uniprot.org/uniprot/U3JPS5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:WTAP ^@ http://purl.uniprot.org/uniprot/A0A803VCK8 ^@ Similarity ^@ Belongs to the fl(2)d family. http://togogenome.org/gene/59894:RSPO1 ^@ http://purl.uniprot.org/uniprot/A0A803V063 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/59894:B4GALT6 ^@ http://purl.uniprot.org/uniprot/U3JTU7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/59894:ALDH8A1 ^@ http://purl.uniprot.org/uniprot/A0A803V0Q7|||http://purl.uniprot.org/uniprot/U3KBL3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:CASR ^@ http://purl.uniprot.org/uniprot/U3JQW5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:DNAL4 ^@ http://purl.uniprot.org/uniprot/U3KD54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59894:MKI67 ^@ http://purl.uniprot.org/uniprot/A0A803W367|||http://purl.uniprot.org/uniprot/U3JEP9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101818212 ^@ http://purl.uniprot.org/uniprot/U3JNM5 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:HPSE2 ^@ http://purl.uniprot.org/uniprot/U3K0S5 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 79 family. http://togogenome.org/gene/59894:SLC6A17 ^@ http://purl.uniprot.org/uniprot/A0A803VLW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:SLC16A14 ^@ http://purl.uniprot.org/uniprot/U3JWW8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RRM2B ^@ http://purl.uniprot.org/uniprot/U3JTN7 ^@ Similarity ^@ Belongs to the ribonucleoside diphosphate reductase small chain family. http://togogenome.org/gene/59894:SDHAF4 ^@ http://purl.uniprot.org/uniprot/U3JWX6 ^@ Similarity ^@ Belongs to the SDHAF4 family. http://togogenome.org/gene/59894:GLB1 ^@ http://purl.uniprot.org/uniprot/U3KD22 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/59894:KCNJ13 ^@ http://purl.uniprot.org/uniprot/A0A803VQH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59894:FAM129A ^@ http://purl.uniprot.org/uniprot/A0A803VTJ6 ^@ Similarity ^@ Belongs to the Niban family. http://togogenome.org/gene/59894:GTDC1 ^@ http://purl.uniprot.org/uniprot/A0A803V1Z1|||http://purl.uniprot.org/uniprot/U3KHE5 ^@ Similarity ^@ Belongs to the glycosyltransferase group 1 family. Glycosyltransferase 4 subfamily. http://togogenome.org/gene/59894:NR1D2 ^@ http://purl.uniprot.org/uniprot/U3K3J8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:LOC101809406 ^@ http://purl.uniprot.org/uniprot/U3KGG9 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/59894:ZRANB1 ^@ http://purl.uniprot.org/uniprot/U3JQI1 ^@ Similarity ^@ Belongs to the peptidase C64 family. http://togogenome.org/gene/59894:ACOX2 ^@ http://purl.uniprot.org/uniprot/U3KFG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the acyl-CoA oxidase family.|||Peroxisome http://togogenome.org/gene/59894:ART4 ^@ http://purl.uniprot.org/uniprot/U3K9Y6 ^@ Similarity ^@ Belongs to the Arg-specific ADP-ribosyltransferase family. http://togogenome.org/gene/59894:CKS1B ^@ http://purl.uniprot.org/uniprot/A0A803VJI7 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/59894:TRAPPC3 ^@ http://purl.uniprot.org/uniprot/A0A803VQI8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||Homodimer.|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/59894:PPM1A ^@ http://purl.uniprot.org/uniprot/A0A803VYX5|||http://purl.uniprot.org/uniprot/U3JLE4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PP2C family.|||Membrane|||cytosol http://togogenome.org/gene/59894:SPO11 ^@ http://purl.uniprot.org/uniprot/U3K8E1 ^@ Similarity ^@ Belongs to the TOP6A family. http://togogenome.org/gene/59894:EEF1B2 ^@ http://purl.uniprot.org/uniprot/U3JMP9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the EF-1-beta/EF-1-delta family.|||EF-1 is composed of 4 subunits: alpha, beta, delta, and gamma.|||EF-1-beta and EF-1-delta stimulate the exchange of GDP bound to EF-1-alpha to GTP. http://togogenome.org/gene/59894:KANSL2 ^@ http://purl.uniprot.org/uniprot/U3JBH3 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ As part of the NSL complex it is involved in acetylation of nucleosomal histone H4 on several lysine residues and therefore may be involved in the regulation of transcription.|||Component of the NSL complex at least composed of MOF/KAT8, KANSL1, KANSL2, KANSL3, MCRS1, PHF20, OGT1/OGT, WDR5 and HCFC1.|||Nucleus http://togogenome.org/gene/59894:LOC101811021 ^@ http://purl.uniprot.org/uniprot/U3JCP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/59894:LOC101810119 ^@ http://purl.uniprot.org/uniprot/U3JKB2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Aquaporins facilitate the transport of water and small neutral solutes across cell membranes.|||Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TUSC3 ^@ http://purl.uniprot.org/uniprot/U3KA81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:CDH2 ^@ http://purl.uniprot.org/uniprot/U3JU31 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PSMB1 ^@ http://purl.uniprot.org/uniprot/U3JKQ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1B family.|||Component of the proteasome complex.|||Component of the proteasome, a multicatalytic proteinase complex which is characterized by its ability to cleave peptides with Arg, Phe, Tyr, Leu, and Glu adjacent to the leaving group at neutral or slightly basic pH. The proteasome has an ATP-dependent proteolytic activity.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SLC16A9 ^@ http://purl.uniprot.org/uniprot/U3JHU2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PHACTR2 ^@ http://purl.uniprot.org/uniprot/A0A803VYG8|||http://purl.uniprot.org/uniprot/U3KE00 ^@ Similarity|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin. http://togogenome.org/gene/59894:SERINC5 ^@ http://purl.uniprot.org/uniprot/A0A803WGX7|||http://purl.uniprot.org/uniprot/U3K5J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ANAPC13 ^@ http://purl.uniprot.org/uniprot/A0A803VDJ4 ^@ Function|||Similarity ^@ Belongs to the APC13 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. The APC/C complex acts by mediating ubiquitination and subsequent degradation of target proteins: it mainly mediates the formation of 'Lys-11'-linked polyubiquitin chains and, to a lower extent, the formation of 'Lys-48'- and 'Lys-63'-linked polyubiquitin chains. http://togogenome.org/gene/59894:ACO1 ^@ http://purl.uniprot.org/uniprot/U3JEK8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Conversely, when cellular iron levels are high, binds a 4Fe-4S cluster which precludes RNA binding activity and promotes the aconitase activity, the isomerization of citrate to isocitrate via cis-aconitate.|||cytosol http://togogenome.org/gene/59894:TRRAP ^@ http://purl.uniprot.org/uniprot/U3KHR8 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. TRA1 subfamily. http://togogenome.org/gene/59894:CSAD ^@ http://purl.uniprot.org/uniprot/U3JP28 ^@ Similarity ^@ Belongs to the group II decarboxylase family. http://togogenome.org/gene/59894:KIF20A ^@ http://purl.uniprot.org/uniprot/U3K2C8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:NMB ^@ http://purl.uniprot.org/uniprot/U3K5M0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bombesin/neuromedin-B/ranatensin family.|||Secreted http://togogenome.org/gene/59894:CMTM3 ^@ http://purl.uniprot.org/uniprot/U3JYX2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LANCL1 ^@ http://purl.uniprot.org/uniprot/U3KF45 ^@ Similarity ^@ Belongs to the LanC-like protein family. http://togogenome.org/gene/59894:SLC7A4 ^@ http://purl.uniprot.org/uniprot/U3JWK9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ENTPD5 ^@ http://purl.uniprot.org/uniprot/U3JUR5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:PHACTR1 ^@ http://purl.uniprot.org/uniprot/A0A803VAW0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatase and actin regulator family.|||Binds PPP1CA and actin.|||Cytoplasm|||Nucleus|||Synapse http://togogenome.org/gene/59894:B3GNT5 ^@ http://purl.uniprot.org/uniprot/U3KLK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:ELOVL4 ^@ http://purl.uniprot.org/uniprot/A0A803VZA3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ELO family. ELOVL4 subfamily.|||Catalyzes the first and rate-limiting reaction of the four reactions that constitute the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process allows the addition of 2 carbons to the chain of long- and very long-chain fatty acids (VLCFAs) per cycle. Condensing enzyme that specifically elongates C24:0 and C26:0 acyl-CoAs. May participate to the production of saturated and monounsaturated VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Membrane|||Oligomer.|||The C-terminal di-lysine motif may confer endoplasmic reticulum localization. http://togogenome.org/gene/59894:ADNP ^@ http://purl.uniprot.org/uniprot/A0A803VKX6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SMARCAL1 ^@ http://purl.uniprot.org/uniprot/A0A803VJW1|||http://purl.uniprot.org/uniprot/U3JMZ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family. SMARCAL1 subfamily.|||Nucleus http://togogenome.org/gene/59894:CCNE2 ^@ http://purl.uniprot.org/uniprot/U3JSS4 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/59894:MAN2A2 ^@ http://purl.uniprot.org/uniprot/A0A803V1R2|||http://purl.uniprot.org/uniprot/U3K9F5 ^@ Cofactor|||Similarity ^@ Belongs to the glycosyl hydrolase 38 family.|||Binds 1 zinc ion per subunit. http://togogenome.org/gene/59894:DYRK4 ^@ http://purl.uniprot.org/uniprot/U3JGW0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/59894:WLS ^@ http://purl.uniprot.org/uniprot/U3KES4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the wntless family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:FGF1 ^@ http://purl.uniprot.org/uniprot/A0A803W399 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the heparin-binding growth factors family.|||Cytoplasm|||Nucleus|||Plays an important role in the regulation of cell survival, cell division, angiogenesis, cell differentiation and cell migration. Functions as potent mitogen in vitro. Acts as a ligand for FGFR1 and integrins. Binds to FGFR1 in the presence of heparin leading to FGFR1 dimerization and activation via sequential autophosphorylation on tyrosine residues which act as docking sites for interacting proteins, leading to the activation of several signaling cascades. Binds to integrins. Its binding to integrins and subsequent ternary complex formation with integrins and FGFR1 are essential for FGF1 signaling.|||Secreted|||cell cortex|||cytosol http://togogenome.org/gene/59894:LOC101816855 ^@ http://purl.uniprot.org/uniprot/U3JTL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the multi antimicrobial extrusion (MATE) (TC 2.A.66.1) family.|||Membrane http://togogenome.org/gene/59894:STX2 ^@ http://purl.uniprot.org/uniprot/A0A803VR47|||http://purl.uniprot.org/uniprot/A0A803W8G9 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:DLL4 ^@ http://purl.uniprot.org/uniprot/U3JUE3 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/59894:LOC101812552 ^@ http://purl.uniprot.org/uniprot/A0A803VZ29 ^@ Cofactor|||Similarity ^@ Belongs to the paraoxonase family.|||Binds 2 calcium ions per subunit. http://togogenome.org/gene/59894:EIF2AK3 ^@ http://purl.uniprot.org/uniprot/U3K6J0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:HDC ^@ http://purl.uniprot.org/uniprot/A0A803VH99 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:SRM ^@ http://purl.uniprot.org/uniprot/U3K6S8 ^@ Similarity ^@ Belongs to the spermidine/spermine synthase family. http://togogenome.org/gene/59894:NMUR1 ^@ http://purl.uniprot.org/uniprot/U3JYT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/59894:CPN1 ^@ http://purl.uniprot.org/uniprot/U3K037 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:KMT5B ^@ http://purl.uniprot.org/uniprot/A0A803V032 ^@ Subcellular Location Annotation ^@ Chromosome|||Nucleus http://togogenome.org/gene/59894:NEK6 ^@ http://purl.uniprot.org/uniprot/U3JHC1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:LOC101810232 ^@ http://purl.uniprot.org/uniprot/U3JQM8 ^@ Similarity ^@ Belongs to the MS4A family. http://togogenome.org/gene/59894:B3GAT1 ^@ http://purl.uniprot.org/uniprot/A0A803V1D9|||http://purl.uniprot.org/uniprot/U3JT62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 43 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:SLC23A2 ^@ http://purl.uniprot.org/uniprot/U3JBW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleobase:cation symporter-2 (NCS2) (TC 2.A.40) family.|||Membrane http://togogenome.org/gene/59894:LOC101817957 ^@ http://purl.uniprot.org/uniprot/A0A803VW13 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:NNT ^@ http://purl.uniprot.org/uniprot/U3K9H5 ^@ Similarity ^@ In the N-terminal section; belongs to the AlaDH/PNT family. http://togogenome.org/gene/59894:ATP6AP2 ^@ http://purl.uniprot.org/uniprot/U3JFQ7 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Lysosome membrane|||Membrane|||autophagosome membrane|||clathrin-coated vesicle membrane|||dendritic spine membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:ENO4 ^@ http://purl.uniprot.org/uniprot/U3JHP3 ^@ Similarity ^@ Belongs to the enolase family. http://togogenome.org/gene/59894:OTUD7A ^@ http://purl.uniprot.org/uniprot/U3KDI3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:FOXN1 ^@ http://purl.uniprot.org/uniprot/U3JVD7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CPSF2 ^@ http://purl.uniprot.org/uniprot/U3JIB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. CPSF2/YSH1 subfamily.|||Nucleus http://togogenome.org/gene/59894:RAB38 ^@ http://purl.uniprot.org/uniprot/U3JZI5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/59894:LOC101812422 ^@ http://purl.uniprot.org/uniprot/A0A803V4S1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:FRZB ^@ http://purl.uniprot.org/uniprot/U3KFC9 ^@ Caution|||Function|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Soluble frizzled-related proteins (sFRPS) function as modulators of Wnt signaling through direct interaction with Wnts. They have a role in regulating cell growth and differentiation in specific cell types. SFRP3/FRZB appears to be involved in limb skeletogenesis. Antagonist of Wnt8 signaling. Regulates chondrocyte maturation and long bone development. http://togogenome.org/gene/59894:MEIS1 ^@ http://purl.uniprot.org/uniprot/U3KGS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/59894:ARHGEF7 ^@ http://purl.uniprot.org/uniprot/U3JP56 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/59894:CCDC126 ^@ http://purl.uniprot.org/uniprot/U3K4Q2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:RPL18A ^@ http://purl.uniprot.org/uniprot/U3K5Q7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL20 family. http://togogenome.org/gene/59894:STON2 ^@ http://purl.uniprot.org/uniprot/U3KDF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adapter protein involved in endocytic machinery. Involved in the synaptic vesicle recycling. May facilitate clathrin-coated vesicle uncoating.|||Belongs to the Stoned B family.|||Cytoplasm|||synaptosome http://togogenome.org/gene/59894:GLRA1 ^@ http://purl.uniprot.org/uniprot/U3K0Q5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Glycine receptor (TC 1.A.9.3) subfamily. GLRA1 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synapse|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/59894:ARL6 ^@ http://purl.uniprot.org/uniprot/U3JG05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||cilium membrane http://togogenome.org/gene/59894:LOC101818310 ^@ http://purl.uniprot.org/uniprot/U3JLF6 ^@ Function ^@ Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form. Binds to G(i)-alpha and G(o)-alpha, but not to G(s)-alpha. http://togogenome.org/gene/59894:CTBP1 ^@ http://purl.uniprot.org/uniprot/U3K636 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/59894:NSMCE2 ^@ http://purl.uniprot.org/uniprot/U3JIN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NSE2 family.|||Nucleus http://togogenome.org/gene/59894:GAD2 ^@ http://purl.uniprot.org/uniprot/U3JXM2 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:MRM2 ^@ http://purl.uniprot.org/uniprot/U3KHL4 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RNA methyltransferase RlmE family. http://togogenome.org/gene/59894:STC2 ^@ http://purl.uniprot.org/uniprot/A0A803VMA4 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/59894:STARD3NL ^@ http://purl.uniprot.org/uniprot/U3JJL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STARD3 family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/59894:LOC101817524 ^@ http://purl.uniprot.org/uniprot/U3KKE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59894:CSK ^@ http://purl.uniprot.org/uniprot/U3K8U1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:DRAM2 ^@ http://purl.uniprot.org/uniprot/A0A803W1N7|||http://purl.uniprot.org/uniprot/U3JID8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:UTP6 ^@ http://purl.uniprot.org/uniprot/U3JHX0 ^@ Similarity ^@ Belongs to the UTP6 family. http://togogenome.org/gene/59894:RAB3IP ^@ http://purl.uniprot.org/uniprot/U3K6K8 ^@ Similarity ^@ Belongs to the SEC2 family. http://togogenome.org/gene/59894:LOC101812359 ^@ http://purl.uniprot.org/uniprot/U3K638 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:CYFIP1 ^@ http://purl.uniprot.org/uniprot/U3JN85 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/59894:SLC13A3 ^@ http://purl.uniprot.org/uniprot/U3JRG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59894:GPRC5C ^@ http://purl.uniprot.org/uniprot/A0A803W071 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:CLCN6 ^@ http://purl.uniprot.org/uniprot/A0A803V8L6|||http://purl.uniprot.org/uniprot/U3K668 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101813935 ^@ http://purl.uniprot.org/uniprot/U3JR80 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:LETM2 ^@ http://purl.uniprot.org/uniprot/U3JVZ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RPRD1A ^@ http://purl.uniprot.org/uniprot/A0A803V0D5|||http://purl.uniprot.org/uniprot/A0A803WBP7 ^@ Similarity ^@ Belongs to the UPF0400 (RTT103) family. http://togogenome.org/gene/59894:KCNG3 ^@ http://purl.uniprot.org/uniprot/U3KDS9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DENND6A ^@ http://purl.uniprot.org/uniprot/U3K125 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DENND6 family.|||Endosome|||Recycling endosome http://togogenome.org/gene/59894:KLHL22 ^@ http://purl.uniprot.org/uniprot/U3JXS3 ^@ Subcellular Location Annotation ^@ Lysosome|||Nucleus|||centrosome|||cytosol|||spindle http://togogenome.org/gene/59894:TCEA3 ^@ http://purl.uniprot.org/uniprot/A0A803V5X8|||http://purl.uniprot.org/uniprot/A0A803V9X3|||http://purl.uniprot.org/uniprot/U3K866 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TFS-II family.|||Necessary for efficient RNA polymerase II transcription elongation past template-encoded arresting sites. The arresting sites in DNA have the property of trapping a certain fraction of elongating RNA polymerases that pass through, resulting in locked ternary complexes. Cleavage of the nascent transcript by S-II allows the resumption of elongation from the new 3'-terminus.|||Nucleus http://togogenome.org/gene/59894:ATG16L1 ^@ http://purl.uniprot.org/uniprot/A0A803W1P7|||http://purl.uniprot.org/uniprot/U3KGG1 ^@ Similarity ^@ Belongs to the WD repeat ATG16 family. http://togogenome.org/gene/59894:LOC101815654 ^@ http://purl.uniprot.org/uniprot/A0A803V0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CPNE3 ^@ http://purl.uniprot.org/uniprot/U3JR63 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/59894:YAE1D1 ^@ http://purl.uniprot.org/uniprot/A0A803WF13 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:MAN1A2 ^@ http://purl.uniprot.org/uniprot/U3JQZ2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/59894:LCORL ^@ http://purl.uniprot.org/uniprot/U3K3L7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TGS1 ^@ http://purl.uniprot.org/uniprot/U3K6N1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. Trimethylguanosine synthase family. http://togogenome.org/gene/59894:ACYP2 ^@ http://purl.uniprot.org/uniprot/A0A803V386 ^@ Similarity ^@ Belongs to the acylphosphatase family. http://togogenome.org/gene/59894:LOC101809259 ^@ http://purl.uniprot.org/uniprot/U3JIJ9 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:RASGRP1 ^@ http://purl.uniprot.org/uniprot/U3JSX8 ^@ Similarity ^@ Belongs to the RASGRP family. http://togogenome.org/gene/59894:DPY19L3 ^@ http://purl.uniprot.org/uniprot/A0A803WED5|||http://purl.uniprot.org/uniprot/U3JBU0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dpy-19 family.|||Membrane|||Probable C-mannosyltransferase that mediates C-mannosylation of tryptophan residues on target proteins. http://togogenome.org/gene/59894:LRRC8D ^@ http://purl.uniprot.org/uniprot/U3KKM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NDST2 ^@ http://purl.uniprot.org/uniprot/U3JX44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/59894:ADAM17 ^@ http://purl.uniprot.org/uniprot/U3JVW2 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TPMT ^@ http://purl.uniprot.org/uniprot/U3KGC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TPMT family.|||Cytoplasm http://togogenome.org/gene/59894:ADIPOR2 ^@ http://purl.uniprot.org/uniprot/A0A803VN69 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ADIPOR family.|||Membrane http://togogenome.org/gene/59894:C2H7orf25 ^@ http://purl.uniprot.org/uniprot/U3KI76 ^@ Similarity ^@ Belongs to the UPF0415 family. http://togogenome.org/gene/59894:LRRC8B ^@ http://purl.uniprot.org/uniprot/U3JG25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SH3GL1 ^@ http://purl.uniprot.org/uniprot/A0A803V9V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:NCK2 ^@ http://purl.uniprot.org/uniprot/A0A803V237 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Endoplasmic reticulum http://togogenome.org/gene/59894:DYNLL1 ^@ http://purl.uniprot.org/uniprot/A0A803V3Z3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59894:TGFBI ^@ http://purl.uniprot.org/uniprot/U3K050 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/59894:VPS4B ^@ http://purl.uniprot.org/uniprot/A0A803V9Z5|||http://purl.uniprot.org/uniprot/U3KEX3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Endosome membrane|||Late endosome membrane|||Membrane http://togogenome.org/gene/59894:LOC101820358 ^@ http://purl.uniprot.org/uniprot/U3K2Z2 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/59894:THNSL1 ^@ http://purl.uniprot.org/uniprot/U3KK25 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/59894:LOC101808879 ^@ http://purl.uniprot.org/uniprot/U3JD40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ITGA11 ^@ http://purl.uniprot.org/uniprot/U3K6D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/59894:LOC101817786 ^@ http://purl.uniprot.org/uniprot/U3K3K6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:GPATCH11 ^@ http://purl.uniprot.org/uniprot/A0A803VNN8|||http://purl.uniprot.org/uniprot/U3KBJ8 ^@ Similarity ^@ Belongs to the GPATCH11 family. http://togogenome.org/gene/59894:PRPF4B ^@ http://purl.uniprot.org/uniprot/U3KFC1 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family.|||Has a role in pre-mRNA splicing. Phosphorylates SF2/ASF. http://togogenome.org/gene/59894:UNC13B ^@ http://purl.uniprot.org/uniprot/A0A803V064|||http://purl.uniprot.org/uniprot/U3K548 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:SIN3B ^@ http://purl.uniprot.org/uniprot/U3KHH1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:OBFC1 ^@ http://purl.uniprot.org/uniprot/U3K2B7 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Component of the CST complex proposed to act as a specialized replication factor promoting DNA replication under conditions of replication stress or natural replication barriers such as the telomere duplex. The CST complex binds single-stranded DNA with high affinity in a sequence-independent manner, while isolated subunits bind DNA with low affinity by themselves. Initially the CST complex has been proposed to protect telomeres from DNA degradation. However, the CST complex has been shown to be involved in several aspects of telomere replication.|||Component of the CST complex.|||Nucleus|||telomere http://togogenome.org/gene/59894:EIF3E ^@ http://purl.uniprot.org/uniprot/U3JUB3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit E family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:RXRG ^@ http://purl.uniprot.org/uniprot/U3JZQ7 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Composed of three domains: a modulating N-terminal domain, a DNA-binding domain and a C-terminal ligand-binding domain.|||Homodimer. Heterodimer; with a rar molecule.|||Nucleus|||Receptor for retinoic acid that acts as a transcription factor. Forms homo- or heterodimers with retinoic acid receptors (rars) and binds to target response elements in response to their ligands, all-trans or 9-cis retinoic acid, to regulate gene expression in various biological processes. http://togogenome.org/gene/59894:GUCY2F ^@ http://purl.uniprot.org/uniprot/U3JYN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Membrane|||Photoreceptor outer segment membrane http://togogenome.org/gene/59894:LOC101809314 ^@ http://purl.uniprot.org/uniprot/A0A803VZ27 ^@ Similarity ^@ Belongs to the cytochrome c oxidase VIIa family. http://togogenome.org/gene/59894:ALOX5AP ^@ http://purl.uniprot.org/uniprot/U3K1F0 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:LOC101809038 ^@ http://purl.uniprot.org/uniprot/U3KKH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:ARAP3 ^@ http://purl.uniprot.org/uniprot/A0A803VHY5|||http://purl.uniprot.org/uniprot/U3JJV7 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:CHRNA1 ^@ http://purl.uniprot.org/uniprot/A0A803VYE0|||http://purl.uniprot.org/uniprot/U3JK53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:FAM221A ^@ http://purl.uniprot.org/uniprot/U3K4P6 ^@ Similarity ^@ Belongs to the FAM221 family. http://togogenome.org/gene/59894:GABRG2 ^@ http://purl.uniprot.org/uniprot/U3KGH9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRG2 sub-subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:CAPN2 ^@ http://purl.uniprot.org/uniprot/U3KBJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C2 family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:ANTXRL ^@ http://purl.uniprot.org/uniprot/A0A803W1S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATR family.|||Membrane http://togogenome.org/gene/59894:TYW3 ^@ http://purl.uniprot.org/uniprot/A0A803VIE7 ^@ Function|||Similarity ^@ Belongs to the TYW3 family.|||Probable S-adenosyl-L-methionine-dependent methyltransferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. http://togogenome.org/gene/59894:ZNF277 ^@ http://purl.uniprot.org/uniprot/U3K4E2 ^@ Similarity ^@ Belongs to the ZNF277 family. http://togogenome.org/gene/59894:SPTAN1 ^@ http://purl.uniprot.org/uniprot/A0A803V212|||http://purl.uniprot.org/uniprot/A0A803W697|||http://purl.uniprot.org/uniprot/A0A803WFW2|||http://purl.uniprot.org/uniprot/U3JFB7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spectrin family.|||cell cortex|||cytoskeleton http://togogenome.org/gene/59894:EPB41L5 ^@ http://purl.uniprot.org/uniprot/A0A803WBU2|||http://purl.uniprot.org/uniprot/U3KFH9 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Photoreceptor inner segment|||Plays a role in the formation and organization of tight junctions during the establishment of polarity in epithelial cells. http://togogenome.org/gene/59894:PRKAB1 ^@ http://purl.uniprot.org/uniprot/U3JZ16 ^@ Function|||Similarity ^@ Belongs to the 5'-AMP-activated protein kinase beta subunit family.|||Non-catalytic subunit of AMP-activated protein kinase (AMPK), an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Beta non-catalytic subunit acts as a scaffold on which the AMPK complex assembles, via its C-terminus that bridges alpha (PRKAA1 or PRKAA2) and gamma subunits (PRKAG1, PRKAG2 or PRKAG3). http://togogenome.org/gene/59894:LTN1 ^@ http://purl.uniprot.org/uniprot/U3JUZ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the LTN1 family.|||Component of the ribosome quality control complex (RQC).|||E3 ubiquitin-protein ligase. Component of the ribosome quality control complex (RQC), a ribosome-associated complex that mediates ubiquitination and extraction of incompletely synthesized nascent chains for proteasomal degradation.|||cytosol http://togogenome.org/gene/59894:LOC101810720 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:SKA1 ^@ http://purl.uniprot.org/uniprot/A0A803W4E4 ^@ Similarity ^@ Belongs to the SKA1 family. http://togogenome.org/gene/59894:LOC101808949 ^@ http://purl.uniprot.org/uniprot/U3JC60 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LACTB2 ^@ http://purl.uniprot.org/uniprot/U3K156 ^@ Function|||Similarity ^@ Belongs to the metallo-beta-lactamase superfamily. Glyoxalase II family.|||Endoribonuclease; cleaves preferentially 3' to purine-pyrimidine dinucleotide motifs in single-stranded RNA. The cleavage product contains a free 3' -OH group. Has no activity with double-stranded RNA or DNA. Required for normal mitochondrial function and cell viability. http://togogenome.org/gene/59894:LOC101807576 ^@ http://purl.uniprot.org/uniprot/U3JEG1 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/59894:DDX52 ^@ http://purl.uniprot.org/uniprot/U3JRI8 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX52/ROK1 subfamily. http://togogenome.org/gene/59894:PSMC2 ^@ http://purl.uniprot.org/uniprot/U3K746 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm http://togogenome.org/gene/59894:KATNAL2 ^@ http://purl.uniprot.org/uniprot/U3K2R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 2 sub-subfamily.|||Cytoplasm|||Severs microtubules in vitro in an ATP-dependent manner. This activity may promote rapid reorganization of cellular microtubule arrays.|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/59894:ATIC ^@ http://purl.uniprot.org/uniprot/U3KEK2 ^@ Similarity ^@ Belongs to the PurH family. http://togogenome.org/gene/59894:OTX2 ^@ http://purl.uniprot.org/uniprot/U3JM64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59894:EIF3D ^@ http://purl.uniprot.org/uniprot/U3KEX8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eIF-3 subunit D family.|||Component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is composed of 13 subunits: EIF3A, EIF3B, EIF3C, EIF3D, EIF3E, EIF3F, EIF3G, EIF3H, EIF3I, EIF3J, EIF3K, EIF3L and EIF3M.|||Cytoplasm|||The RNA gate region regulates mRNA cap recognition to prevent promiscuous mRNA-binding before assembly of eif3d into the full eukaryotic translation initiation factor 3 (eIF-3) complex.|||mRNA cap-binding component of the eukaryotic translation initiation factor 3 (eIF-3) complex, which is involved in protein synthesis of a specialized repertoire of mRNAs and, together with other initiation factors, stimulates binding of mRNA and methionyl-tRNAi to the 40S ribosome. The eIF-3 complex specifically targets and initiates translation of a subset of mRNAs involved in cell proliferation. In the eIF-3 complex, eif3d specifically recognizes and binds the 7-methylguanosine cap of a subset of mRNAs. http://togogenome.org/gene/59894:GJA1 ^@ http://purl.uniprot.org/uniprot/U3KLL1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:ND3 ^@ http://purl.uniprot.org/uniprot/S0ASL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 3 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity of complex I.|||Mitochondrion membrane http://togogenome.org/gene/59894:GCNT7 ^@ http://purl.uniprot.org/uniprot/A0A803WDA7|||http://purl.uniprot.org/uniprot/U3K8M4 ^@ Subcellular Location Annotation ^@ Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:AVL9 ^@ http://purl.uniprot.org/uniprot/U3JJ20 ^@ Subcellular Location Annotation ^@ Endosome|||Recycling endosome http://togogenome.org/gene/59894:RPAP2 ^@ http://purl.uniprot.org/uniprot/U3JGB9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with the RNA polymerase II complex.|||Belongs to the RPAP2 family.|||Nucleus|||Protein phosphatase that displays CTD phosphatase activity and regulates transcription of snRNA genes. Recognizes and binds phosphorylated 'Ser-7' of the C-terminal heptapeptide repeat domain (CTD) of the largest RNA polymerase II subunit POLR2A, and mediates dephosphorylation of 'Ser-5' of the CTD, thereby promoting transcription of snRNA genes. http://togogenome.org/gene/59894:CTNNB1 ^@ http://purl.uniprot.org/uniprot/A0A803V4M6|||http://purl.uniprot.org/uniprot/U3KCN8 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/59894:DGCR14 ^@ http://purl.uniprot.org/uniprot/A0A803V228 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESS2 family.|||Nucleus http://togogenome.org/gene/59894:GUF1 ^@ http://purl.uniprot.org/uniprot/A0A803VF01 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTP-binding elongation factor family. LepA subfamily.|||Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. LepA subfamily.|||Mitochondrion inner membrane|||Promotes mitochondrial protein synthesis. May act as a fidelity factor of the translation reaction, by catalyzing a one-codon backward translocation of tRNAs on improperly translocated ribosomes. Binds to mitochondrial ribosomes in a GTP-dependent manner. http://togogenome.org/gene/59894:TATDN1 ^@ http://purl.uniprot.org/uniprot/U3JIM3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. TatD-type hydrolase family. http://togogenome.org/gene/59894:LOC101818144 ^@ http://purl.uniprot.org/uniprot/U3KI73 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:DPT ^@ http://purl.uniprot.org/uniprot/U3JT48 ^@ Similarity ^@ Belongs to the dermatopontin family. http://togogenome.org/gene/59894:CASP7 ^@ http://purl.uniprot.org/uniprot/A0A803VAZ6 ^@ Similarity ^@ Belongs to the peptidase C14A family. http://togogenome.org/gene/59894:HEBP1 ^@ http://purl.uniprot.org/uniprot/A0A803WFF0 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/59894:HSF4 ^@ http://purl.uniprot.org/uniprot/U3JYX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HSF family.|||Nucleus http://togogenome.org/gene/59894:TSC22D2 ^@ http://purl.uniprot.org/uniprot/U3JRS7 ^@ Similarity ^@ Belongs to the TSC-22/Dip/Bun family. http://togogenome.org/gene/59894:CENPI ^@ http://purl.uniprot.org/uniprot/U3KAB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-I/CTF3 family.|||Nucleus|||centromere http://togogenome.org/gene/59894:LOC101815017 ^@ http://purl.uniprot.org/uniprot/A0A803W0R0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDC42SE/SPEC family.|||Cell membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/59894:SAR1A ^@ http://purl.uniprot.org/uniprot/U3KDW0 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/59894:NUP93 ^@ http://purl.uniprot.org/uniprot/U3JYH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleoporin interacting component (NIC) family.|||Nucleus membrane|||Plays a role in the nuclear pore complex (NPC) assembly and/or maintenance.|||nuclear pore complex http://togogenome.org/gene/59894:LOC101815990 ^@ http://purl.uniprot.org/uniprot/A0A803V6F1 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/59894:LOC101808840 ^@ http://purl.uniprot.org/uniprot/U3KKH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:PLCD1 ^@ http://purl.uniprot.org/uniprot/A0A803WDQ9 ^@ Cofactor ^@ Binds 3 Ca(2+) ions per subunit. Two of the Ca(2+) ions are bound to the C2 domain. http://togogenome.org/gene/59894:ABCG1 ^@ http://purl.uniprot.org/uniprot/U3JH79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/59894:POMGNT2 ^@ http://purl.uniprot.org/uniprot/U3KIZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 61 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LYPD6 ^@ http://purl.uniprot.org/uniprot/A0A803VGR5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:PIK3CB ^@ http://purl.uniprot.org/uniprot/U3JN97 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/59894:LOC101815170 ^@ http://purl.uniprot.org/uniprot/A0A803VAY6 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:GPX7 ^@ http://purl.uniprot.org/uniprot/A0A803WDZ0 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/59894:PTEN ^@ http://purl.uniprot.org/uniprot/A0A803VMH1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a dual-specificity protein phosphatase, dephosphorylating tyrosine-, serine- and threonine-phosphorylated proteins. Also acts as a lipid phosphatase, removing the phosphate in the D3 position of the inositol ring from phosphatidylinositol 3,4,5-trisphosphate, phosphatidylinositol 3,4-diphosphate, phosphatidylinositol 3-phosphate and inositol 1,3,4,5-tetrakisphosphate with order of substrate preference in vitro PtdIns(3,4,5)P3 > PtdIns(3,4)P2 > PtdIns3P > Ins(1,3,4,5)P4.|||Belongs to the PTEN phosphatase protein family.|||Cytoplasm|||Nucleus|||PML body|||Postsynaptic density|||dendritic spine http://togogenome.org/gene/59894:PDE1A ^@ http://purl.uniprot.org/uniprot/A0A803VTQ9|||http://purl.uniprot.org/uniprot/A0A803VZ62|||http://purl.uniprot.org/uniprot/U3JLV3 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE1 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:OPRL1 ^@ http://purl.uniprot.org/uniprot/U3K6Z3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for the endogenous neuropeptide nociceptin. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling via G proteins mediates inhibition of adenylate cyclase activity and calcium channel activity. Arrestins modulate signaling via G proteins and mediate the activation of alternative signaling pathways that lead to the activation of MAP kinases. Plays a role in modulating nociception and the perception of pain. Plays a role in the regulation of locomotor activity by the neuropeptide nociceptin.|||Membrane|||Vesicle http://togogenome.org/gene/59894:MC3R ^@ http://purl.uniprot.org/uniprot/U3KKY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane http://togogenome.org/gene/59894:CCT4 ^@ http://purl.uniprot.org/uniprot/U3K8V4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/59894:F3 ^@ http://purl.uniprot.org/uniprot/U3JI36 ^@ Function|||Similarity|||Subunit ^@ Belongs to the tissue factor family.|||Initiates blood coagulation by forming a complex with circulating factor VII or VIIa. The [TF:VIIa] complex activates factors IX or X by specific limited proteolysis. TF plays a role in normal hemostasis by initiating the cell-surface assembly and propagation of the coagulation protease cascade.|||Interacts with HSPE; the interaction, inhibited by heparin, promotes the generation of activated factor X and activates coagulation in the presence of activated factor VII. http://togogenome.org/gene/59894:LOC101817018 ^@ http://purl.uniprot.org/uniprot/U3KIF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM151 family.|||Membrane http://togogenome.org/gene/59894:DUSP1 ^@ http://purl.uniprot.org/uniprot/U3K2F1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Nucleus http://togogenome.org/gene/59894:ADRB2 ^@ http://purl.uniprot.org/uniprot/U3KJ44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:XPOT ^@ http://purl.uniprot.org/uniprot/U3K5R1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the exportin family.|||Cytoplasm|||Nucleus|||tRNA nucleus export receptor which facilitates tRNA translocation across the nuclear pore complex. http://togogenome.org/gene/59894:LOC101811636 ^@ http://purl.uniprot.org/uniprot/U3JTX0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transthyretin family.|||Homotetramer.|||Secreted|||Thyroid hormone-binding protein. Probably transports thyroxine from the bloodstream to the brain. http://togogenome.org/gene/59894:LOC101812092 ^@ http://purl.uniprot.org/uniprot/A0A803W1T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IFI6/IFI27 family.|||Membrane http://togogenome.org/gene/59894:NPC1 ^@ http://purl.uniprot.org/uniprot/U3JUE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the patched family.|||Membrane http://togogenome.org/gene/59894:LOC101808317 ^@ http://purl.uniprot.org/uniprot/U3KKV4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:DNM3 ^@ http://purl.uniprot.org/uniprot/A0A803V9V3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/59894:UNC45B ^@ http://purl.uniprot.org/uniprot/U3K534 ^@ Subcellular Location Annotation ^@ A band|||Z line|||perinuclear region http://togogenome.org/gene/59894:LOC101817211 ^@ http://purl.uniprot.org/uniprot/A0A803WFM7|||http://purl.uniprot.org/uniprot/U3KAF5 ^@ Caution|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-5/CLCN5 subfamily.|||Cell membrane|||Endosome membrane|||Golgi apparatus membrane|||Interacts with NEDD4 and NEDD4L.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:CAPN11 ^@ http://purl.uniprot.org/uniprot/U3K9T7 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59894:ZWILCH ^@ http://purl.uniprot.org/uniprot/U3KEA7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ZWILCH family.|||Component of the RZZ complex.|||Essential component of the mitotic checkpoint, which prevents cells from prematurely exiting mitosis. Required for the assembly of the dynein-dynactin and MAD1-MAD2 complexes onto kinetochores. Its function related to the spindle assembly machinery is proposed to depend on its association in the mitotic RZZ complex.|||kinetochore http://togogenome.org/gene/59894:LSS ^@ http://purl.uniprot.org/uniprot/U3KFR9 ^@ Similarity ^@ Belongs to the terpene cyclase/mutase family. http://togogenome.org/gene/59894:RTEL1 ^@ http://purl.uniprot.org/uniprot/U3JTN0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ ATP-dependent DNA helicase implicated in telomere-length regulation, DNA repair and the maintenance of genomic stability. Acts as an anti-recombinase to counteract toxic recombination and limit crossover during meiosis. Regulates meiotic recombination and crossover homeostasis by physically dissociating strand invasion events and thereby promotes noncrossover repair by meiotic synthesis dependent strand annealing (SDSA) as well as disassembly of D loop recombination intermediates. Also disassembles T loops and prevents telomere fragility by counteracting telomeric G4-DNA structures, which together ensure the dynamics and stability of the telomere.|||Belongs to the helicase family. RAD3/XPD subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:UCKL1 ^@ http://purl.uniprot.org/uniprot/A0A803WEF6 ^@ Similarity ^@ Belongs to the uridine kinase family. http://togogenome.org/gene/59894:ST3GAL6 ^@ http://purl.uniprot.org/uniprot/A0A803V0K5|||http://purl.uniprot.org/uniprot/A0A803VTE2|||http://purl.uniprot.org/uniprot/A0A803W4L2|||http://purl.uniprot.org/uniprot/U3JTB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:TENM4 ^@ http://purl.uniprot.org/uniprot/U3JYZ0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:ETFDH ^@ http://purl.uniprot.org/uniprot/U3JK69 ^@ Cofactor|||Function ^@ Accepts electrons from ETF and reduces ubiquinone.|||Binds 1 [4Fe-4S] cluster. http://togogenome.org/gene/59894:TPD52 ^@ http://purl.uniprot.org/uniprot/A0A803W1G2 ^@ Similarity ^@ Belongs to the TPD52 family. http://togogenome.org/gene/59894:MTMR10 ^@ http://purl.uniprot.org/uniprot/U3KDH2 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/59894:LOC101813267 ^@ http://purl.uniprot.org/uniprot/U3JH78 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ATP6V0A4 ^@ http://purl.uniprot.org/uniprot/U3K337 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase 116 kDa subunit family.|||Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase.|||Membrane http://togogenome.org/gene/59894:COQ10B ^@ http://purl.uniprot.org/uniprot/U3JNU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the COQ10 family.|||Interacts with coenzyme Q.|||Required for the function of coenzyme Q in the respiratory chain. May serve as a chaperone or may be involved in the transport of Q6 from its site of synthesis to the catalytic sites of the respiratory complexes. http://togogenome.org/gene/59894:ATP12A ^@ http://purl.uniprot.org/uniprot/U3JT89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIC subfamily.|||Cell membrane http://togogenome.org/gene/59894:PLXNA4 ^@ http://purl.uniprot.org/uniprot/A0A803VY74 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PCSK5 ^@ http://purl.uniprot.org/uniprot/A0A803VL98|||http://purl.uniprot.org/uniprot/U3K3C2 ^@ Similarity ^@ Belongs to the peptidase S8 family. http://togogenome.org/gene/59894:RTCB ^@ http://purl.uniprot.org/uniprot/U3KFW2 ^@ Cofactor|||Function|||Miscellaneous|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RtcB family.|||Binds 2 manganese ions per subunit.|||Catalytic component of the tRNA-splicing ligase complex.|||Catalytic subunit of the tRNA-splicing ligase complex that acts by directly joining spliced tRNA halves to mature-sized tRNAs by incorporating the precursor-derived splice junction phosphate into the mature tRNA as a canonical 3',5'-phosphodiester. May act as an RNA ligase with broad substrate specificity, and may function toward other RNAs.|||Cytoplasm|||Ligation probably proceeds through 3 nucleotidyl transfer steps, with 2',3'-cyclic phosphate termini being hydrolyzed to 3'-P termini in a step that precedes 3'-P activation with GMP. In the first nucleotidyl transfer step, RTCB reacts with GTP to form a covalent RTCB-histidine-GMP intermediate with release of PPi; in the second step, the GMP moiety is transferred to the RNA 3'-P; in the third step, the 5'-OH from the opposite RNA strand attacks the activated 3'-P to form a 3',5'-phosphodiester bond and release GMP. http://togogenome.org/gene/59894:LOC101807360 ^@ http://purl.uniprot.org/uniprot/A0A803W1Q7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/59894:BTBD10 ^@ http://purl.uniprot.org/uniprot/A0A803WE69|||http://purl.uniprot.org/uniprot/U3K7W1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:KARS ^@ http://purl.uniprot.org/uniprot/U3JIR9 ^@ Similarity ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:VPS37A ^@ http://purl.uniprot.org/uniprot/U3KA03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/59894:SLC25A20 ^@ http://purl.uniprot.org/uniprot/U3KF92 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:SLC41A2 ^@ http://purl.uniprot.org/uniprot/A0A803VY27|||http://purl.uniprot.org/uniprot/U3KGB3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/59894:SGCG ^@ http://purl.uniprot.org/uniprot/A0A803W4J7|||http://purl.uniprot.org/uniprot/U3K231 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/59894:SLC26A7 ^@ http://purl.uniprot.org/uniprot/U3JRY3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane http://togogenome.org/gene/59894:ARHGEF6 ^@ http://purl.uniprot.org/uniprot/U3JMA9 ^@ Subcellular Location Annotation ^@ lamellipodium http://togogenome.org/gene/59894:PTPRM ^@ http://purl.uniprot.org/uniprot/U3JV32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 2B subfamily.|||Membrane http://togogenome.org/gene/59894:GRB14 ^@ http://purl.uniprot.org/uniprot/U3K0T2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GRB7/10/14 family.|||Cytoplasm http://togogenome.org/gene/59894:AFF1 ^@ http://purl.uniprot.org/uniprot/U3JSP0 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/59894:KCNS2 ^@ http://purl.uniprot.org/uniprot/U3KKJ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RAF1 ^@ http://purl.uniprot.org/uniprot/U3JB65|||http://purl.uniprot.org/uniprot/U3JB66 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. RAF subfamily. http://togogenome.org/gene/59894:SLC16A5 ^@ http://purl.uniprot.org/uniprot/U3JES7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:POLR1A ^@ http://purl.uniprot.org/uniprot/U3K665 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta' chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/59894:HAL ^@ http://purl.uniprot.org/uniprot/A0A803V5Z7 ^@ Similarity ^@ Belongs to the PAL/histidase family. http://togogenome.org/gene/59894:CZH9orf3 ^@ http://purl.uniprot.org/uniprot/U3JLK7 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/59894:PITPNM2 ^@ http://purl.uniprot.org/uniprot/A0A803VQ82|||http://purl.uniprot.org/uniprot/A0A803VX65|||http://purl.uniprot.org/uniprot/A0A803WA08|||http://purl.uniprot.org/uniprot/U3K3P2 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/59894:GEM ^@ http://purl.uniprot.org/uniprot/U3JSC4 ^@ Similarity ^@ Belongs to the small GTPase superfamily. RGK family. http://togogenome.org/gene/59894:DOK6 ^@ http://purl.uniprot.org/uniprot/U3JPR0 ^@ Similarity ^@ Belongs to the DOK family. Type B subfamily. http://togogenome.org/gene/59894:GMNN ^@ http://purl.uniprot.org/uniprot/A0A803W2B0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the geminin family.|||Nucleus http://togogenome.org/gene/59894:HPS5 ^@ http://purl.uniprot.org/uniprot/U3K9B1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the HPS5 family.|||Component of the biogenesis of lysosome-related organelles complex-2 (or BLOC2) composed of HPS3, HPS5 and HPS6.|||May regulate the synthesis and function of lysosomes and of highly specialized organelles, such as melanosomes and platelet dense granules.|||cytosol http://togogenome.org/gene/59894:CPT1A ^@ http://purl.uniprot.org/uniprot/U3KDP0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the carnitine/choline acetyltransferase family.|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:CRMP1 ^@ http://purl.uniprot.org/uniprot/U3K4P1 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/59894:LOC101819490 ^@ http://purl.uniprot.org/uniprot/U3KJ91 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101810446 ^@ http://purl.uniprot.org/uniprot/A0A803V5L4|||http://purl.uniprot.org/uniprot/U3K9B9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TK1 ^@ http://purl.uniprot.org/uniprot/U3KCF4 ^@ Similarity ^@ Belongs to the thymidine kinase family. http://togogenome.org/gene/59894:MEOX1 ^@ http://purl.uniprot.org/uniprot/U3JDJ8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MAFF ^@ http://purl.uniprot.org/uniprot/U3KDQ9 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/59894:LCA5L ^@ http://purl.uniprot.org/uniprot/U3JR11 ^@ Similarity ^@ Belongs to the LCA5 family. http://togogenome.org/gene/59894:RAPGEF6 ^@ http://purl.uniprot.org/uniprot/U3JE69 ^@ Similarity ^@ Belongs to the RAPGEF2 family. http://togogenome.org/gene/59894:STK38L ^@ http://purl.uniprot.org/uniprot/U3JMU5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:ALDH1L2 ^@ http://purl.uniprot.org/uniprot/U3KG77 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family.|||In the C-terminal section; belongs to the aldehyde dehydrogenase family. ALDH1L subfamily.|||In the N-terminal section; belongs to the GART family. http://togogenome.org/gene/59894:ORAI2 ^@ http://purl.uniprot.org/uniprot/A0A803WAG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/59894:LOC101817239 ^@ http://purl.uniprot.org/uniprot/A0A803V5A2 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/59894:ATRNL1 ^@ http://purl.uniprot.org/uniprot/A0A803VAB6|||http://purl.uniprot.org/uniprot/U3JHR6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LEPROT ^@ http://purl.uniprot.org/uniprot/U3KE13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OB-RGRP/VPS55 family.|||Membrane http://togogenome.org/gene/59894:FAM188B ^@ http://purl.uniprot.org/uniprot/U3JDI1 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM188 subfamily.|||Hydrolase that can remove 'Lys-48'-linked conjugated ubiquitin from proteins. http://togogenome.org/gene/59894:AKR1A1 ^@ http://purl.uniprot.org/uniprot/U3K4S3 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the aldo/keto reductase family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:SORL1 ^@ http://purl.uniprot.org/uniprot/U3JTL2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS10-related sortilin family. SORL1 subfamily.|||Cell membrane|||Early endosome membrane|||Endoplasmic reticulum membrane|||Endosome membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Recycling endosome membrane|||Secreted|||multivesicular body membrane|||secretory vesicle membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:TMEM63A ^@ http://purl.uniprot.org/uniprot/U3KAX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSC1 (TC 1.A.17) family.|||Membrane http://togogenome.org/gene/59894:TOP3B ^@ http://purl.uniprot.org/uniprot/U3JZQ9 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/59894:EZH2 ^@ http://purl.uniprot.org/uniprot/U3K6U9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ATF4 ^@ http://purl.uniprot.org/uniprot/A0A803VTZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family.|||Nucleus http://togogenome.org/gene/59894:STX16 ^@ http://purl.uniprot.org/uniprot/U3K845 ^@ Similarity ^@ Belongs to the syntaxin family. http://togogenome.org/gene/59894:SGCD ^@ http://purl.uniprot.org/uniprot/U3K132 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan beta/delta/gamma/zeta family.|||cytoskeleton|||sarcolemma http://togogenome.org/gene/59894:GSG1L ^@ http://purl.uniprot.org/uniprot/U3JN58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GSG1 family.|||Membrane http://togogenome.org/gene/59894:GPSM2 ^@ http://purl.uniprot.org/uniprot/U3JJ45 ^@ Similarity ^@ Belongs to the GPSM family. http://togogenome.org/gene/59894:LOC101820994 ^@ http://purl.uniprot.org/uniprot/U3KK66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family.|||Nucleus http://togogenome.org/gene/59894:ODC1 ^@ http://purl.uniprot.org/uniprot/U3JVY9 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/59894:PDHA1 ^@ http://purl.uniprot.org/uniprot/U3JNT7 ^@ Function ^@ The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2), and thereby links the glycolytic pathway to the tricarboxylic cycle. http://togogenome.org/gene/59894:ZDHHC22 ^@ http://purl.uniprot.org/uniprot/A0A803V2E1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:POFUT1 ^@ http://purl.uniprot.org/uniprot/U3JSB3 ^@ Similarity ^@ Belongs to the glycosyltransferase 65 family. http://togogenome.org/gene/59894:RPS6 ^@ http://purl.uniprot.org/uniprot/U3JK94 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS6 family. http://togogenome.org/gene/59894:AZIN1 ^@ http://purl.uniprot.org/uniprot/U3JTR1 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/59894:CDC42BPB ^@ http://purl.uniprot.org/uniprot/A0A803VS94|||http://purl.uniprot.org/uniprot/U3JJF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. DMPK subfamily.|||lamellipodium http://togogenome.org/gene/59894:LOC101817760 ^@ http://purl.uniprot.org/uniprot/A0A803W4X1 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:PBRM1 ^@ http://purl.uniprot.org/uniprot/A0A803V2U9|||http://purl.uniprot.org/uniprot/A0A803V958|||http://purl.uniprot.org/uniprot/A0A803V9J1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101810386 ^@ http://purl.uniprot.org/uniprot/U3KH06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the somatotropin/prolactin family.|||Secreted http://togogenome.org/gene/59894:UBE2K ^@ http://purl.uniprot.org/uniprot/A0A803WAR4|||http://purl.uniprot.org/uniprot/U3K3L8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:CKS2 ^@ http://purl.uniprot.org/uniprot/U3KD79 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CKS family.|||Binds to the catalytic subunit of the cyclin dependent kinases and is essential for their biological function.|||Forms a homohexamer that can probably bind six kinase subunits. http://togogenome.org/gene/59894:INS ^@ http://purl.uniprot.org/uniprot/U3KAN7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the insulin family.|||Heterodimer of a B chain and an A chain linked by two disulfide bonds.|||Insulin decreases blood glucose concentration. It increases cell permeability to monosaccharides, amino acids and fatty acids. It accelerates glycolysis, the pentose phosphate cycle, and glycogen synthesis in liver.|||Secreted http://togogenome.org/gene/59894:ZCCHC6 ^@ http://purl.uniprot.org/uniprot/U3JLP8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/59894:A2M ^@ http://purl.uniprot.org/uniprot/U3JY34 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/59894:TTC38 ^@ http://purl.uniprot.org/uniprot/U3JJL8 ^@ Similarity ^@ Belongs to the TTC38 family. http://togogenome.org/gene/59894:ANXA6 ^@ http://purl.uniprot.org/uniprot/U3K0D5 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ A pair of annexin repeats may form one binding site for calcium and phospholipid.|||Belongs to the annexin family.|||May associate with CD21. May regulate the release of Ca(2+) from intracellular stores.|||Melanosome http://togogenome.org/gene/59894:TRAPPC3L ^@ http://purl.uniprot.org/uniprot/U3K8Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. BET3 subfamily.|||Endoplasmic reticulum|||May play a role in vesicular transport from endoplasmic reticulum to Golgi.|||cis-Golgi network http://togogenome.org/gene/59894:LOC101817527 ^@ http://purl.uniprot.org/uniprot/U3JNQ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:PHOSPHO2 ^@ http://purl.uniprot.org/uniprot/U3KJI7 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. PHOSPHO family. http://togogenome.org/gene/59894:VIPR1 ^@ http://purl.uniprot.org/uniprot/A0A803VX39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101808612 ^@ http://purl.uniprot.org/uniprot/U3KBG0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/59894:CASP6 ^@ http://purl.uniprot.org/uniprot/A0A803VZY0 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C14A family.|||Cytoplasm|||Heterotetramer that consists of two anti-parallel arranged heterodimers, each one formed by a 18 kDa (Caspase-6 subunit p18) and a 11 kDa (Caspase-6 subunit p11) subunit.|||Nucleus http://togogenome.org/gene/59894:PRICKLE1 ^@ http://purl.uniprot.org/uniprot/U3K6N7 ^@ Similarity ^@ Belongs to the prickle / espinas / testin family. http://togogenome.org/gene/59894:RHBDD1 ^@ http://purl.uniprot.org/uniprot/U3JWJ7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SYCP2 ^@ http://purl.uniprot.org/uniprot/U3K7X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SYCP2 family.|||Nucleus http://togogenome.org/gene/59894:MED8 ^@ http://purl.uniprot.org/uniprot/U3JSP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 8 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors. May play a role as a target recruitment subunit in E3 ubiquitin-protein ligase complexes and thus in ubiquitination and subsequent proteasomal degradation of target proteins.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59894:NR2F1 ^@ http://purl.uniprot.org/uniprot/A0A803VDV8|||http://purl.uniprot.org/uniprot/A0A803W9Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:LOC101817208 ^@ http://purl.uniprot.org/uniprot/A0A803V733|||http://purl.uniprot.org/uniprot/U3JBR9 ^@ Similarity ^@ Belongs to the vasopressin/oxytocin family. http://togogenome.org/gene/59894:COQ9 ^@ http://purl.uniprot.org/uniprot/A0A803VDS0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the COQ9 family.|||Lipid-binding protein involved in the biosynthesis of coenzyme Q, also named ubiquinone, an essential lipid-soluble electron transporter for aerobic cellular respiration.|||Mitochondrion http://togogenome.org/gene/59894:PACS2 ^@ http://purl.uniprot.org/uniprot/U3JLU6 ^@ Similarity ^@ Belongs to the PACS family. http://togogenome.org/gene/59894:PRKAR1A ^@ http://purl.uniprot.org/uniprot/U3JIJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:POLR2H ^@ http://purl.uniprot.org/uniprot/U3K0G7 ^@ Function|||Similarity ^@ Belongs to the eukaryotic RPB8 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Common component of RNA polymerases I, II and III which synthesize ribosomal RNA precursors, mRNA precursors and many functional non-coding RNAs, and small RNAs, such as 5S rRNA and tRNAs, respectively. http://togogenome.org/gene/59894:PMM2 ^@ http://purl.uniprot.org/uniprot/U3JN15 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic PMM family.|||Cytoplasm|||Homodimer.|||Involved in the synthesis of the GDP-mannose and dolichol-phosphate-mannose required for a number of critical mannosyl transfer reactions. http://togogenome.org/gene/59894:F13A1 ^@ http://purl.uniprot.org/uniprot/A0A803WDU8|||http://purl.uniprot.org/uniprot/U3KFI9 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/59894:ERLEC1 ^@ http://purl.uniprot.org/uniprot/U3KA28 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum lumen http://togogenome.org/gene/59894:KIF11 ^@ http://purl.uniprot.org/uniprot/A0A803VX22|||http://purl.uniprot.org/uniprot/U3JZT0 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:KNG1 ^@ http://purl.uniprot.org/uniprot/U3K0L9 ^@ Subcellular Location Annotation ^@ extracellular space http://togogenome.org/gene/59894:GREM1 ^@ http://purl.uniprot.org/uniprot/A0A803VYF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DAN family.|||Secreted http://togogenome.org/gene/59894:LOC101820237 ^@ http://purl.uniprot.org/uniprot/A0A803VSG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CDC42EP3 ^@ http://purl.uniprot.org/uniprot/U3KLJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORG/CEP family.|||Endomembrane system http://togogenome.org/gene/59894:CCDC53 ^@ http://purl.uniprot.org/uniprot/A0A803VX15 ^@ Similarity ^@ Belongs to the CCDC53 family. http://togogenome.org/gene/59894:FGD5 ^@ http://purl.uniprot.org/uniprot/U3KGX9 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:LOC101818836 ^@ http://purl.uniprot.org/uniprot/U3KF02 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:PRRX2 ^@ http://purl.uniprot.org/uniprot/U3JFE1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/59894:LRRC42 ^@ http://purl.uniprot.org/uniprot/U3KBW7 ^@ Similarity ^@ Belongs to the LRRC42 family. http://togogenome.org/gene/59894:PTCD3 ^@ http://purl.uniprot.org/uniprot/A0A803V866|||http://purl.uniprot.org/uniprot/U3K669 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS39 family.|||Mitochondrion http://togogenome.org/gene/59894:UNC50 ^@ http://purl.uniprot.org/uniprot/U3JMY7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-50 family.|||Membrane|||Nucleus inner membrane http://togogenome.org/gene/59894:LOC101818042 ^@ http://purl.uniprot.org/uniprot/U3JQR5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alpha-carbonic anhydrase family.|||Cytoplasm|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:DUT ^@ http://purl.uniprot.org/uniprot/A0A803VM14 ^@ Function|||Similarity ^@ Belongs to the dUTPase family.|||This enzyme is involved in nucleotide metabolism: it produces dUMP, the immediate precursor of thymidine nucleotides and it decreases the intracellular concentration of dUTP so that uracil cannot be incorporated into DNA. http://togogenome.org/gene/59894:MTFR1 ^@ http://purl.uniprot.org/uniprot/A0A803VER5|||http://purl.uniprot.org/uniprot/U3JSF0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/59894:ACVR2A ^@ http://purl.uniprot.org/uniprot/U3KHF5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:PUS7L ^@ http://purl.uniprot.org/uniprot/U3K6I8 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/59894:NDEL1 ^@ http://purl.uniprot.org/uniprot/A0A803VMI6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nudE family.|||centrosome|||spindle http://togogenome.org/gene/59894:GPM6B ^@ http://purl.uniprot.org/uniprot/A0A803V6I5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin proteolipid protein family.|||Membrane http://togogenome.org/gene/59894:USP5 ^@ http://purl.uniprot.org/uniprot/U3JQ23 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:LYPLAL1 ^@ http://purl.uniprot.org/uniprot/U3KCI8 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. AB hydrolase 2 family. http://togogenome.org/gene/59894:SYK ^@ http://purl.uniprot.org/uniprot/U3JQ94 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. SYK/ZAP-70 subfamily. http://togogenome.org/gene/59894:LOC101812529 ^@ http://purl.uniprot.org/uniprot/A0A803WGK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/59894:SLC30A4 ^@ http://purl.uniprot.org/uniprot/U3KAC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/59894:SPI1 ^@ http://purl.uniprot.org/uniprot/A0A803W3S7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:HDAC8 ^@ http://purl.uniprot.org/uniprot/U3KBX2 ^@ Similarity ^@ Belongs to the histone deacetylase family. HD type 1 subfamily. http://togogenome.org/gene/59894:RAP2B ^@ http://purl.uniprot.org/uniprot/U3KJ89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Ras family.|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/59894:LPAR5 ^@ http://purl.uniprot.org/uniprot/U3KJF1 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:PCID2 ^@ http://purl.uniprot.org/uniprot/U3JKP5 ^@ Similarity ^@ Belongs to the CSN12 family. http://togogenome.org/gene/59894:TET1 ^@ http://purl.uniprot.org/uniprot/U3KEX9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TET family.|||Binds 1 Fe(2+) ion per subunit.|||Chromosome|||Dioxygenase that catalyzes the conversion of the modified genomic base 5-methylcytosine (5mC) into 5-hydroxymethylcytosine (5hmC) and plays a key role in epigenetic chromatin reprogramming during embryonic development.|||The zinc ions have a structural role. http://togogenome.org/gene/59894:GPLD1 ^@ http://purl.uniprot.org/uniprot/U3KGH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPLD1 family.|||Secreted http://togogenome.org/gene/59894:CGA ^@ http://purl.uniprot.org/uniprot/U3JJS4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycoprotein hormones subunit alpha family.|||Heterodimer of an alpha and a beta chain.|||Secreted http://togogenome.org/gene/59894:TNFAIP3 ^@ http://purl.uniprot.org/uniprot/U3KEG7 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CHUK ^@ http://purl.uniprot.org/uniprot/A0A803VGK2 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CRAT ^@ http://purl.uniprot.org/uniprot/U3JFD7 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/59894:ARMC8 ^@ http://purl.uniprot.org/uniprot/A0A803VDA8|||http://purl.uniprot.org/uniprot/U3KG93 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:PPP4R3B ^@ http://purl.uniprot.org/uniprot/U3K9K3 ^@ Similarity ^@ Belongs to the SMEK family. http://togogenome.org/gene/59894:TAF4 ^@ http://purl.uniprot.org/uniprot/U3K7T8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF4 family.|||Nucleus http://togogenome.org/gene/59894:MEIS2 ^@ http://purl.uniprot.org/uniprot/U3JSY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/MEIS homeobox family.|||Nucleus http://togogenome.org/gene/59894:UXS1 ^@ http://purl.uniprot.org/uniprot/U3JLU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. UDP-glucuronic acid decarboxylase subfamily.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:SLC45A1 ^@ http://purl.uniprot.org/uniprot/A0A803V1Y5|||http://purl.uniprot.org/uniprot/U3K5N3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SLC16A6 ^@ http://purl.uniprot.org/uniprot/A0A803W7Y5|||http://purl.uniprot.org/uniprot/U3JIF2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TMEM150A ^@ http://purl.uniprot.org/uniprot/U3JXS2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SLC30A1 ^@ http://purl.uniprot.org/uniprot/U3KDD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family. SLC30A subfamily.|||Membrane http://togogenome.org/gene/59894:PSMD5 ^@ http://purl.uniprot.org/uniprot/U3JGG4 ^@ Similarity ^@ Belongs to the proteasome subunit S5B/HSM3 family. http://togogenome.org/gene/59894:RORB ^@ http://purl.uniprot.org/uniprot/A0A803VCJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:SUSD2 ^@ http://purl.uniprot.org/uniprot/U3K0S9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:RPL36 ^@ http://purl.uniprot.org/uniprot/U3KBT7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL36 family. http://togogenome.org/gene/59894:GCG ^@ http://purl.uniprot.org/uniprot/U3JD74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/59894:GRM3 ^@ http://purl.uniprot.org/uniprot/U3JGX9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.|||Interacts with TAMALIN.|||Membrane http://togogenome.org/gene/59894:ADGRL2 ^@ http://purl.uniprot.org/uniprot/A0A803VFA0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:FAM20B ^@ http://purl.uniprot.org/uniprot/U3K0J0 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/59894:TEAD3 ^@ http://purl.uniprot.org/uniprot/A0A803V810|||http://purl.uniprot.org/uniprot/A0A803VKR1|||http://purl.uniprot.org/uniprot/U3JLY4 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||Transcription factor which plays a key role in the Hippo signaling pathway, a pathway involved in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. http://togogenome.org/gene/59894:USP1 ^@ http://purl.uniprot.org/uniprot/U3KDE3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:FGFR2 ^@ http://purl.uniprot.org/uniprot/A0A803V6C7|||http://purl.uniprot.org/uniprot/A0A803VS65|||http://purl.uniprot.org/uniprot/U3JHI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Fibroblast growth factor receptor subfamily.|||Membrane http://togogenome.org/gene/59894:SYPL1 ^@ http://purl.uniprot.org/uniprot/A0A803V5W8|||http://purl.uniprot.org/uniprot/U3K6R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptophysin/synaptobrevin family.|||Membrane http://togogenome.org/gene/59894:DIP2C ^@ http://purl.uniprot.org/uniprot/A0A803VHS5|||http://purl.uniprot.org/uniprot/A0A803VN55|||http://purl.uniprot.org/uniprot/U3JWV4 ^@ Similarity ^@ Belongs to the DIP2 family. http://togogenome.org/gene/59894:ZDHHC13 ^@ http://purl.uniprot.org/uniprot/U3JFX9 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. AKR/ZDHHC17 subfamily.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:GPR157 ^@ http://purl.uniprot.org/uniprot/U3JY19 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PRPH2 ^@ http://purl.uniprot.org/uniprot/U3KDQ0 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/59894:TXNRD3 ^@ http://purl.uniprot.org/uniprot/U3JZI1 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/59894:LOC101813101 ^@ http://purl.uniprot.org/uniprot/U3KBU7 ^@ Similarity ^@ Belongs to the major facilitator (TC 2.A.1) superfamily. Organic cation transporter (TC 2.A.1.19) family. http://togogenome.org/gene/59894:KCNJ4 ^@ http://purl.uniprot.org/uniprot/A0A803VZD7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59894:USP35 ^@ http://purl.uniprot.org/uniprot/A0A803W0S3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:IL15 ^@ http://purl.uniprot.org/uniprot/A0A803VDK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IL-15/IL-21 family.|||Secreted http://togogenome.org/gene/59894:CCNG2 ^@ http://purl.uniprot.org/uniprot/U3K1G1 ^@ Similarity ^@ Belongs to the cyclin family. http://togogenome.org/gene/59894:AMOT ^@ http://purl.uniprot.org/uniprot/U3K8Y7 ^@ Similarity ^@ Belongs to the angiomotin family. http://togogenome.org/gene/59894:RELL1 ^@ http://purl.uniprot.org/uniprot/A0A803WCL0 ^@ Similarity ^@ Belongs to the RELT family. http://togogenome.org/gene/59894:HAO2 ^@ http://purl.uniprot.org/uniprot/U3JR20 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/59894:SMARCD3 ^@ http://purl.uniprot.org/uniprot/A0A803WEN8 ^@ Similarity ^@ Belongs to the SMARCD family. http://togogenome.org/gene/59894:MYH9 ^@ http://purl.uniprot.org/uniprot/U3KF79 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:ALX1 ^@ http://purl.uniprot.org/uniprot/U3K7J7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family.|||Nucleus http://togogenome.org/gene/59894:CNTN1 ^@ http://purl.uniprot.org/uniprot/U3K6Y1 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. Contactin family. http://togogenome.org/gene/59894:BAK1 ^@ http://purl.uniprot.org/uniprot/U3JMQ7 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/59894:SPTBN1 ^@ http://purl.uniprot.org/uniprot/A0A803WC77|||http://purl.uniprot.org/uniprot/U3K9Y0 ^@ Similarity ^@ Belongs to the spectrin family. http://togogenome.org/gene/59894:CDK6 ^@ http://purl.uniprot.org/uniprot/U3K755 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:YKT6 ^@ http://purl.uniprot.org/uniprot/U3JBA8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Cytoplasmic vesicle membrane|||Golgi apparatus membrane|||Membrane|||Vesicular soluble NSF attachment protein receptor (v-SNARE) mediating vesicle docking and fusion to a specific acceptor cellular compartment. Functions in endoplasmic reticulum to Golgi transport; as part of a SNARE complex composed of GOSR1, GOSR2 and STX5. Functions in early/recycling endosome to TGN transport; as part of a SNARE complex composed of BET1L, GOSR1 and STX5. Has a S-palmitoyl transferase activity. http://togogenome.org/gene/59894:ING3 ^@ http://purl.uniprot.org/uniprot/U3K5V4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/59894:SLC45A4 ^@ http://purl.uniprot.org/uniprot/U3K2A8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TMEM175 ^@ http://purl.uniprot.org/uniprot/A0A803VMK8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM175 family.|||Membrane http://togogenome.org/gene/59894:SCN4A ^@ http://purl.uniprot.org/uniprot/U3KGZ5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel (TC 1.A.1.10) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Mediates the voltage-dependent sodium ion permeability of excitable membranes. Assuming opened or closed conformations in response to the voltage difference across the membrane, the protein forms a sodium-selective channel through which Na(+) ions may pass in accordance with their electrochemical gradient.|||Membrane http://togogenome.org/gene/59894:CCBL2 ^@ http://purl.uniprot.org/uniprot/U3JG24 ^@ Subunit ^@ Homodimer. http://togogenome.org/gene/59894:NDUFA5 ^@ http://purl.uniprot.org/uniprot/U3K5L9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA5 subunit family.|||Complex I is composed of 45 different subunits.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:PLAT ^@ http://purl.uniprot.org/uniprot/A0A803VAU6|||http://purl.uniprot.org/uniprot/U3JV78 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:OSBPL2 ^@ http://purl.uniprot.org/uniprot/U3K7P4 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:DSEL ^@ http://purl.uniprot.org/uniprot/U3KJJ8 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/59894:SERPIND1 ^@ http://purl.uniprot.org/uniprot/U3JZK7 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:EXOSC1 ^@ http://purl.uniprot.org/uniprot/U3K1A1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:FBLN1 ^@ http://purl.uniprot.org/uniprot/U3JJJ7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the fibulin family.|||Homomultimerizes and interacts with various extracellular matrix components.|||Incorporated into fibronectin-containing matrix fibers. May play a role in cell adhesion and migration along protein fibers within the extracellular matrix (ECM). Could be important for certain developmental processes and contribute to the supramolecular organization of ECM architecture, in particular to those of basement membranes.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:TBX20 ^@ http://purl.uniprot.org/uniprot/U3JJ86 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:GTPBP1 ^@ http://purl.uniprot.org/uniprot/U3KDB3 ^@ Function ^@ Promotes degradation of target mRNA species. Plays a role in the regulation of circadian mRNA stability. Binds GTP and has GTPase activity. http://togogenome.org/gene/59894:AMH ^@ http://purl.uniprot.org/uniprot/A0A803VYW1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/59894:SLC16A3 ^@ http://purl.uniprot.org/uniprot/A0A803V0X7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/59894:CPQ ^@ http://purl.uniprot.org/uniprot/A0A803VGU2 ^@ Subcellular Location Annotation|||Subunit ^@ Endoplasmic reticulum|||Golgi apparatus|||Homodimer. The monomeric form is inactive while the homodimer is active.|||Lysosome|||Secreted http://togogenome.org/gene/59894:DHX9 ^@ http://purl.uniprot.org/uniprot/U3JK12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family. DEAH subfamily.|||Nucleus http://togogenome.org/gene/59894:DYNC1I2 ^@ http://purl.uniprot.org/uniprot/A0A803VI14|||http://purl.uniprot.org/uniprot/U3JH23 ^@ Similarity ^@ Belongs to the dynein intermediate chain family. http://togogenome.org/gene/59894:SCOC ^@ http://purl.uniprot.org/uniprot/A0A803VN81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SCOC family.|||Positive regulator of amino acid starvation-induced autophagy.|||trans-Golgi network http://togogenome.org/gene/59894:ROMO1 ^@ http://purl.uniprot.org/uniprot/U3KDE2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MGR2 family.|||Has antibacterial activity against a variety of bacteria including S.aureus, P.aeruginosa and M.tuberculosis. Acts by inducing bacterial membrane breakage.|||Induces production of reactive oxygen species (ROS) which are necessary for cell proliferation. May play a role in inducing oxidative DNA damage and replicative senescence. May play a role in the coordination of mitochondrial morphology and cell proliferation.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:NARFL ^@ http://purl.uniprot.org/uniprot/A0A803VYJ9|||http://purl.uniprot.org/uniprot/A0A803WGK8 ^@ Similarity ^@ Belongs to the NARF family. http://togogenome.org/gene/59894:GFOD1 ^@ http://purl.uniprot.org/uniprot/U3KG07 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/59894:KIF14 ^@ http://purl.uniprot.org/uniprot/U3JJ76 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:RAB39B ^@ http://purl.uniprot.org/uniprot/A0A803W210 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:PTPN21 ^@ http://purl.uniprot.org/uniprot/A0A803VZ32|||http://purl.uniprot.org/uniprot/U3KD96 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/59894:PEX5L ^@ http://purl.uniprot.org/uniprot/A0A803V614|||http://purl.uniprot.org/uniprot/A0A803VNN3|||http://purl.uniprot.org/uniprot/U3K0Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal targeting signal receptor family.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:LOC101818227 ^@ http://purl.uniprot.org/uniprot/A0A803VC67|||http://purl.uniprot.org/uniprot/U3K3K7 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:APIP ^@ http://purl.uniprot.org/uniprot/A0A803VY89 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aldolase class II family. Adducin subfamily.|||Belongs to the aldolase class II family. MtnB subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the dehydration of methylthioribulose-1-phosphate (MTRu-1-P) into 2,3-diketo-5-methylthiopentyl-1-phosphate (DK-MTP-1-P). Functions in the methionine salvage pathway. May play a role in apoptosis.|||Cytoplasm http://togogenome.org/gene/59894:MYH7B ^@ http://purl.uniprot.org/uniprot/U3JTH8 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:MBP ^@ http://purl.uniprot.org/uniprot/A0A803W4Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the myelin basic protein family.|||Myelin membrane http://togogenome.org/gene/59894:TSPOAP1 ^@ http://purl.uniprot.org/uniprot/A0A803VNS4|||http://purl.uniprot.org/uniprot/U3KH51 ^@ Similarity ^@ Belongs to the RIMBP family. http://togogenome.org/gene/59894:AASDH ^@ http://purl.uniprot.org/uniprot/A0A803W1R3|||http://purl.uniprot.org/uniprot/A0A803WE17 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:GPAT4 ^@ http://purl.uniprot.org/uniprot/U3JVA5 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:ENPP4 ^@ http://purl.uniprot.org/uniprot/A0A803WAG2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family.|||Cell membrane|||Hydrolyzes extracellular Ap3A into AMP and ADP, and Ap4A into AMP and ATP. Ap3A and Ap4A are diadenosine polyphosphates thought to induce proliferation of vascular smooth muscle cells. Acts as a procoagulant, mediating platelet aggregation at the site of nascent thrombus via release of ADP from Ap3A and activation of ADP receptors.|||Membrane http://togogenome.org/gene/59894:LOC101820209 ^@ http://purl.uniprot.org/uniprot/A0A803V323 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ZGPAT ^@ http://purl.uniprot.org/uniprot/U3JTS2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101816142 ^@ http://purl.uniprot.org/uniprot/U3JHB9 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:ABHD12 ^@ http://purl.uniprot.org/uniprot/U3JDG9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the serine esterase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:WNT2B ^@ http://purl.uniprot.org/uniprot/U3JD43 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:C1H11orf70 ^@ http://purl.uniprot.org/uniprot/U3JC63 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CFAP300 family.|||Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. May play a role in outer and inner dynein arm assembly.|||Cytoplasm http://togogenome.org/gene/59894:FGGY ^@ http://purl.uniprot.org/uniprot/U3KD05 ^@ Similarity ^@ Belongs to the FGGY kinase family. http://togogenome.org/gene/59894:TBXAS1 ^@ http://purl.uniprot.org/uniprot/A0A803WBL9|||http://purl.uniprot.org/uniprot/U3K343 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:STC1 ^@ http://purl.uniprot.org/uniprot/U3K9B2 ^@ Similarity|||Subunit ^@ Belongs to the stanniocalcin family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/59894:CLDN16 ^@ http://purl.uniprot.org/uniprot/U3JY20 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:HTR1D ^@ http://purl.uniprot.org/uniprot/U3KIP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:DSG4 ^@ http://purl.uniprot.org/uniprot/U3JTY6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||desmosome http://togogenome.org/gene/59894:TAF1B ^@ http://purl.uniprot.org/uniprot/U3JVW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRN7/TAF1B family.|||nucleolus http://togogenome.org/gene/59894:AMPD2 ^@ http://purl.uniprot.org/uniprot/U3JJU3 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Adenosine and AMP deaminases family. http://togogenome.org/gene/59894:CDK2AP1 ^@ http://purl.uniprot.org/uniprot/A0A803VML3 ^@ Similarity ^@ Belongs to the CDK2AP family. http://togogenome.org/gene/59894:SNX8 ^@ http://purl.uniprot.org/uniprot/A0A803VB01|||http://purl.uniprot.org/uniprot/U3KHL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sorting nexin family.|||Membrane http://togogenome.org/gene/59894:RRM1 ^@ http://purl.uniprot.org/uniprot/U3K6Q9 ^@ Function|||Similarity ^@ Belongs to the ribonucleoside diphosphate reductase large chain family.|||Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides. http://togogenome.org/gene/59894:CALHM2 ^@ http://purl.uniprot.org/uniprot/U3K2A3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59894:LOC101814966 ^@ http://purl.uniprot.org/uniprot/U3K717 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:TECRL ^@ http://purl.uniprot.org/uniprot/U3JTL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the steroid 5-alpha reductase family.|||Membrane http://togogenome.org/gene/59894:ASRGL1 ^@ http://purl.uniprot.org/uniprot/A0A803W920 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/59894:FAM20A ^@ http://purl.uniprot.org/uniprot/U3JIK2 ^@ Similarity ^@ Belongs to the FAM20 family. http://togogenome.org/gene/59894:OGFR ^@ http://purl.uniprot.org/uniprot/A0A803VH38 ^@ Similarity ^@ Belongs to the opioid growth factor receptor family. http://togogenome.org/gene/59894:NSA2 ^@ http://purl.uniprot.org/uniprot/U3K673 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic ribosomal protein eS8 family. Ribosome biogenesis protein NSA2 subfamily.|||Component of the pre-66S ribosomal particle.|||Involved in the biogenesis of the 60S ribosomal subunit. May play a part in the quality control of pre-60S particles.|||nucleolus http://togogenome.org/gene/59894:MRPS18A ^@ http://purl.uniprot.org/uniprot/U3K9Z4 ^@ Subcellular Location Annotation ^@ Mitochondrion http://togogenome.org/gene/59894:FAM192A ^@ http://purl.uniprot.org/uniprot/U3JX05 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101817587 ^@ http://purl.uniprot.org/uniprot/U3KIU4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:SLC7A13 ^@ http://purl.uniprot.org/uniprot/A0A803W6B0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:RPS27A ^@ http://purl.uniprot.org/uniprot/A0A803V5N6 ^@ Similarity|||Subunit ^@ In the C-terminal section; belongs to the eukaryotic ribosomal protein eS31 family.|||In the N-terminal section; belongs to the ubiquitin family.|||Ribosomal protein S27a is part of the 40S ribosomal subunit. http://togogenome.org/gene/59894:VGLL1 ^@ http://purl.uniprot.org/uniprot/A0A803V0R3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vestigial family.|||Nucleus http://togogenome.org/gene/59894:ERBB2 ^@ http://purl.uniprot.org/uniprot/U3JCP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:WDFY2 ^@ http://purl.uniprot.org/uniprot/A0A803VC80|||http://purl.uniprot.org/uniprot/U3K1E0 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59894:DHRS11 ^@ http://purl.uniprot.org/uniprot/A0A803VZM4 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:CFDP1 ^@ http://purl.uniprot.org/uniprot/U3JYF5 ^@ Function|||Subcellular Location Annotation ^@ May play a role during embryogenesis.|||kinetochore http://togogenome.org/gene/59894:SYT16 ^@ http://purl.uniprot.org/uniprot/U3JL59 ^@ Similarity ^@ Belongs to the synaptotagmin family. http://togogenome.org/gene/59894:LOC101816047 ^@ http://purl.uniprot.org/uniprot/U3K6Y0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:HMMR ^@ http://purl.uniprot.org/uniprot/U3KGI8 ^@ Subcellular Location Annotation ^@ spindle http://togogenome.org/gene/59894:ASIC4 ^@ http://purl.uniprot.org/uniprot/U3JNX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amiloride-sensitive sodium channel (TC 1.A.6) family.|||Membrane http://togogenome.org/gene/59894:LOC101810537 ^@ http://purl.uniprot.org/uniprot/A0A803W491 ^@ Similarity ^@ Belongs to the serpin family. Ov-serpin subfamily. http://togogenome.org/gene/59894:LOC101809041 ^@ http://purl.uniprot.org/uniprot/U3JMI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WASH1 family.|||Early endosome membrane|||Endosome membrane|||Recycling endosome membrane http://togogenome.org/gene/59894:CLVS2 ^@ http://purl.uniprot.org/uniprot/A0A803VWU4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/59894:RALB ^@ http://purl.uniprot.org/uniprot/A0A803WBB2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/59894:HEXB ^@ http://purl.uniprot.org/uniprot/U3K6H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 20 family.|||Lysosome http://togogenome.org/gene/59894:KLHL15 ^@ http://purl.uniprot.org/uniprot/A0A803W3Y2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ST7 ^@ http://purl.uniprot.org/uniprot/A0A803W1K5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ST7 family.|||Membrane http://togogenome.org/gene/59894:RAB3B ^@ http://purl.uniprot.org/uniprot/U3JSL8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/59894:PDK3 ^@ http://purl.uniprot.org/uniprot/U3JND3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDK/BCKDK protein kinase family.|||Mitochondrion matrix http://togogenome.org/gene/59894:OLFM3 ^@ http://purl.uniprot.org/uniprot/A0A803VLU1 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/59894:SLC7A3 ^@ http://purl.uniprot.org/uniprot/U3KBP3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:FAM168A ^@ http://purl.uniprot.org/uniprot/A0A803VP75 ^@ Similarity ^@ Belongs to the FAM168 family. http://togogenome.org/gene/59894:SLC5A1 ^@ http://purl.uniprot.org/uniprot/U3JY54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:TXNL4B ^@ http://purl.uniprot.org/uniprot/A0A803VXP4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DIM1 family.|||Nucleus|||Plays role in pre-mRNA splicing. http://togogenome.org/gene/59894:IL1RAPL2 ^@ http://purl.uniprot.org/uniprot/U3JG17 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59894:RPAP1 ^@ http://purl.uniprot.org/uniprot/U3JU85 ^@ Similarity ^@ Belongs to the RPAP1 family. http://togogenome.org/gene/59894:TBPL1 ^@ http://purl.uniprot.org/uniprot/U3KBI6 ^@ Similarity ^@ Belongs to the TBP family. http://togogenome.org/gene/59894:PPP3R1 ^@ http://purl.uniprot.org/uniprot/U3KGU1 ^@ Similarity ^@ Belongs to the calcineurin regulatory subunit family. http://togogenome.org/gene/59894:CHRNB4 ^@ http://purl.uniprot.org/uniprot/U3K7X4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:PSMA6 ^@ http://purl.uniprot.org/uniprot/U3JU26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase T1A family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:VANGL1 ^@ http://purl.uniprot.org/uniprot/U3JUA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Vang family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:JAG2 ^@ http://purl.uniprot.org/uniprot/A0A803WBX8|||http://purl.uniprot.org/uniprot/U3JKA8 ^@ Caution|||Function|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Putative Notch ligand involved in the mediation of Notch signaling. http://togogenome.org/gene/59894:RECQL ^@ http://purl.uniprot.org/uniprot/U3JIZ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the helicase family. RecQ subfamily.|||Nucleus http://togogenome.org/gene/59894:SSH2 ^@ http://purl.uniprot.org/uniprot/A0A803VBF8|||http://purl.uniprot.org/uniprot/U3JUP1 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/59894:TSPAN1 ^@ http://purl.uniprot.org/uniprot/U3K4G4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:SMAD3 ^@ http://purl.uniprot.org/uniprot/A0A803V7Y8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CTLA4 ^@ http://purl.uniprot.org/uniprot/U3JM89 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Inhibitory receptor acting as a major negative regulator of T-cell responses. The affinity of CTLA4 for its natural B7 family ligands, CD80 and CD86, is considerably stronger than the affinity of their cognate stimulatory coreceptor CD28.|||Membrane http://togogenome.org/gene/59894:RPL15 ^@ http://purl.uniprot.org/uniprot/A0A803WET6 ^@ Function|||Similarity ^@ Belongs to the eukaryotic ribosomal protein eL15 family.|||Component of the large ribosomal subunit. The ribosome is a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. http://togogenome.org/gene/59894:GMDS ^@ http://purl.uniprot.org/uniprot/A0A803V3H7|||http://purl.uniprot.org/uniprot/U3KF28 ^@ Similarity ^@ Belongs to the NAD(P)-dependent epimerase/dehydratase family. GDP-mannose 4,6-dehydratase subfamily. http://togogenome.org/gene/59894:LOC101813211 ^@ http://purl.uniprot.org/uniprot/U3KA04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/59894:GAL3ST2 ^@ http://purl.uniprot.org/uniprot/A0A803V1X9 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/59894:DBX1 ^@ http://purl.uniprot.org/uniprot/U3JG39 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ORMDL3 ^@ http://purl.uniprot.org/uniprot/A0A803VES7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORM family.|||Endoplasmic reticulum membrane|||Membrane|||Negative regulator of sphingolipid synthesis. http://togogenome.org/gene/59894:ARL3 ^@ http://purl.uniprot.org/uniprot/A0A803V9D9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||centrosome http://togogenome.org/gene/59894:VPS41 ^@ http://purl.uniprot.org/uniprot/A0A803V8H0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS41 family.|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Plays a role in vesicle-mediated protein trafficking to lysosomal compartments including the endocytic membrane transport pathways.|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/59894:KCNK5 ^@ http://purl.uniprot.org/uniprot/A0A803V502 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59894:FMN1 ^@ http://purl.uniprot.org/uniprot/A0A803W6Y9|||http://purl.uniprot.org/uniprot/U3JSS5 ^@ Similarity ^@ Belongs to the formin homology family. Cappuccino subfamily. http://togogenome.org/gene/59894:CLVS1 ^@ http://purl.uniprot.org/uniprot/U3JSM4 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Endosome membrane|||Vesicle|||clathrin-coated vesicle|||trans-Golgi network membrane http://togogenome.org/gene/59894:NGLY1 ^@ http://purl.uniprot.org/uniprot/U3K3H7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transglutaminase-like superfamily. PNGase family.|||Cytoplasm|||Specifically deglycosylates the denatured form of N-linked glycoproteins in the cytoplasm and assists their proteasome-mediated degradation. Cleaves the beta-aspartyl-glucosamine (GlcNAc) of the glycan and the amide side chain of Asn, converting Asn to Asp. Prefers proteins containing high-mannose over those bearing complex type oligosaccharides. Can recognize misfolded proteins in the endoplasmic reticulum that are exported to the cytosol to be destroyed and deglycosylate them, while it has no activity toward native proteins. Deglycosylation is a prerequisite for subsequent proteasome-mediated degradation of some, but not all, misfolded glycoproteins. http://togogenome.org/gene/59894:GPRIN3 ^@ http://purl.uniprot.org/uniprot/U3KKA8 ^@ Function ^@ May be involved in neurite outgrowth. http://togogenome.org/gene/59894:NFIA ^@ http://purl.uniprot.org/uniprot/U3KD71 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/59894:BCR ^@ http://purl.uniprot.org/uniprot/A0A803VE73|||http://purl.uniprot.org/uniprot/U3JY17 ^@ Subcellular Location Annotation ^@ Synapse|||axon|||dendritic spine http://togogenome.org/gene/59894:PLXNA1 ^@ http://purl.uniprot.org/uniprot/U3JZI4 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plexin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TMEM116 ^@ http://purl.uniprot.org/uniprot/U3K2X3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:KATNA1 ^@ http://purl.uniprot.org/uniprot/U3KCD9|||http://purl.uniprot.org/uniprot/U3KCE0 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||centrosome|||spindle|||spindle pole http://togogenome.org/gene/59894:LOC101814418 ^@ http://purl.uniprot.org/uniprot/A0A803V6S5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TOR1AIP family.|||Membrane http://togogenome.org/gene/59894:TCP11L1 ^@ http://purl.uniprot.org/uniprot/U3K896 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/59894:RSL24D1 ^@ http://purl.uniprot.org/uniprot/U3KBX8 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL24 family. http://togogenome.org/gene/59894:LOC101808993 ^@ http://purl.uniprot.org/uniprot/U3JRL8 ^@ Similarity ^@ Belongs to the SelWTH family. Selenoprotein T subfamily. http://togogenome.org/gene/59894:MYH10 ^@ http://purl.uniprot.org/uniprot/U3K3Y7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:CTBP2 ^@ http://purl.uniprot.org/uniprot/U3JQJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family.|||Nucleus http://togogenome.org/gene/59894:PRKG2 ^@ http://purl.uniprot.org/uniprot/U3JTC2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cGMP subfamily. http://togogenome.org/gene/59894:PSMC3IP ^@ http://purl.uniprot.org/uniprot/A0A803WGJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HOP2 family.|||Nucleus http://togogenome.org/gene/59894:ATP7A ^@ http://purl.uniprot.org/uniprot/U3K8S3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:TASP1 ^@ http://purl.uniprot.org/uniprot/A0A803VXL4 ^@ Similarity ^@ Belongs to the Ntn-hydrolase family. http://togogenome.org/gene/59894:HAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VGF4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HAT1 family.|||Catalytic subunit of the type B histone acetyltransferase (HAT) complex, composed of RBBP7 and HAT1. Interacts with histones H4 and H2A.|||Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair. Coordinates histone production and acetylation via H4 promoter binding. Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac). http://togogenome.org/gene/59894:GDF9 ^@ http://purl.uniprot.org/uniprot/A0A803V0Q4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TGF-beta family.|||Homodimer or heterodimer (Potential). But, in contrast to other members of this family, cannot be disulfide-linked.|||Secreted http://togogenome.org/gene/59894:SENP7 ^@ http://purl.uniprot.org/uniprot/A0A803VAU2|||http://purl.uniprot.org/uniprot/A0A803VM09|||http://purl.uniprot.org/uniprot/A0A803W682|||http://purl.uniprot.org/uniprot/U3JVH1 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/59894:SVOP ^@ http://purl.uniprot.org/uniprot/U3K2I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/59894:POMT1 ^@ http://purl.uniprot.org/uniprot/U3JFG5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 39 family.|||Endoplasmic reticulum membrane|||Membrane|||Transfers mannose from Dol-P-mannose to Ser or Thr residues on proteins. http://togogenome.org/gene/59894:BRE ^@ http://purl.uniprot.org/uniprot/A0A803VK29|||http://purl.uniprot.org/uniprot/U3K8E0 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BABAM2 family.|||Component of the ARISC complex. Component of the BRCA1-A complex. Component of the BRISC complex. Binds polyubiquitin.|||Contains 2 ubiquitin-conjugating enzyme family-like (UEV-like) regions. These regions lack the critical Cys residues required for ubiquitination but retain the ability to bind ubiquitin.|||Cytoplasm|||May play a role in homeostasis or cellular differentiation in cells of neural, epithelial and germline origins. May also act as a death receptor-associated anti-apoptotic protein, which inhibits the mitochondrial apoptotic pathway.|||Nucleus http://togogenome.org/gene/59894:USE1 ^@ http://purl.uniprot.org/uniprot/A0A803W1W0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the USE1 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MDH2 ^@ http://purl.uniprot.org/uniprot/U3K4T6 ^@ Similarity|||Subunit ^@ Belongs to the LDH/MDH superfamily. MDH type 1 family.|||Homodimer. http://togogenome.org/gene/59894:LOC101817308 ^@ http://purl.uniprot.org/uniprot/U3K5Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNF-like-inhibitor family.|||Secreted http://togogenome.org/gene/59894:SLC11A1 ^@ http://purl.uniprot.org/uniprot/A0A803VQY0|||http://purl.uniprot.org/uniprot/U3JN57 ^@ Similarity ^@ Belongs to the NRAMP family. http://togogenome.org/gene/59894:ADRA1D ^@ http://purl.uniprot.org/uniprot/A0A803VWQ7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with FLNA (via filamin repeat 21); increases PKA-mediated phosphorylation of FLNA.|||Membrane|||This alpha-adrenergic receptor mediates its effect through the influx of extracellular calcium. http://togogenome.org/gene/59894:FAM167A ^@ http://purl.uniprot.org/uniprot/A0A803VNM2 ^@ Similarity ^@ Belongs to the FAM167 (SEC) family. http://togogenome.org/gene/59894:MYT1 ^@ http://purl.uniprot.org/uniprot/U3K6Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MYT1 family.|||Nucleus http://togogenome.org/gene/59894:MST1R ^@ http://purl.uniprot.org/uniprot/U3K2W1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:RPS15A ^@ http://purl.uniprot.org/uniprot/U3KI09 ^@ Similarity|||Subunit ^@ Belongs to the universal ribosomal protein uS8 family.|||Component of the 40S ribosomal subunit. http://togogenome.org/gene/59894:ATAD1 ^@ http://purl.uniprot.org/uniprot/U3KF84 ^@ Similarity ^@ Belongs to the AAA ATPase family. http://togogenome.org/gene/59894:TRPM7 ^@ http://purl.uniprot.org/uniprot/U3KA58 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||In the C-terminal section; belongs to the protein kinase superfamily. Alpha-type protein kinase family. ALPK subfamily.|||Membrane http://togogenome.org/gene/59894:ONECUT1 ^@ http://purl.uniprot.org/uniprot/U3KBR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/59894:SDPR ^@ http://purl.uniprot.org/uniprot/U3JP13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/59894:TOP3A ^@ http://purl.uniprot.org/uniprot/U3KH13 ^@ Function|||Similarity ^@ Belongs to the type IA topoisomerase family.|||Introduces a single-strand break via transesterification at a target site in duplex DNA. Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. http://togogenome.org/gene/59894:APTX ^@ http://purl.uniprot.org/uniprot/U3JES6 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||nucleolus|||nucleoplasm http://togogenome.org/gene/59894:ZC3H15 ^@ http://purl.uniprot.org/uniprot/A0A803V2K2 ^@ Similarity ^@ Belongs to the ZC3H15/TMA46 family. http://togogenome.org/gene/59894:DEGS2 ^@ http://purl.uniprot.org/uniprot/A0A803W495|||http://purl.uniprot.org/uniprot/A0A803W4D6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the fatty acid desaturase type 1 family. DEGS subfamily.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:GABPA ^@ http://purl.uniprot.org/uniprot/U3KBW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:DMRT2 ^@ http://purl.uniprot.org/uniprot/U3K735 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DMRT family.|||Nucleus http://togogenome.org/gene/59894:GDPD5 ^@ http://purl.uniprot.org/uniprot/A0A803VI36|||http://purl.uniprot.org/uniprot/A0A803VYQ0|||http://purl.uniprot.org/uniprot/U3JVX5 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/59894:LOC101820502 ^@ http://purl.uniprot.org/uniprot/U3JTY3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:XDH ^@ http://purl.uniprot.org/uniprot/U3KAG6 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Peroxisome http://togogenome.org/gene/59894:PLOD1 ^@ http://purl.uniprot.org/uniprot/U3K618 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:LOC101808643 ^@ http://purl.uniprot.org/uniprot/A0A803WBF3 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/59894:LOC101809482 ^@ http://purl.uniprot.org/uniprot/U3JSX4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:C3H6orf120 ^@ http://purl.uniprot.org/uniprot/U3KLP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0669 family.|||Secreted http://togogenome.org/gene/59894:STEAP2 ^@ http://purl.uniprot.org/uniprot/A0A803VWB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STEAP family.|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:MAST3 ^@ http://purl.uniprot.org/uniprot/A0A803VG65 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/59894:MET ^@ http://purl.uniprot.org/uniprot/A0A803VZ61 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PPP1R21 ^@ http://purl.uniprot.org/uniprot/U3K987 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59894:MSI1 ^@ http://purl.uniprot.org/uniprot/U3JYP5 ^@ Similarity ^@ Belongs to the Musashi family. http://togogenome.org/gene/59894:NDUFB5 ^@ http://purl.uniprot.org/uniprot/A0A803VMC3 ^@ Function|||Similarity|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB5 subunit family.|||Complex I is composed of 45 different subunits. http://togogenome.org/gene/59894:PPP6R3 ^@ http://purl.uniprot.org/uniprot/A0A803VET0|||http://purl.uniprot.org/uniprot/A0A803W670|||http://purl.uniprot.org/uniprot/A0A803WGP3 ^@ Similarity ^@ Belongs to the SAPS family. http://togogenome.org/gene/59894:AP3M2 ^@ http://purl.uniprot.org/uniprot/U3JV89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Cytoplasmic vesicle membrane|||Golgi apparatus http://togogenome.org/gene/59894:FAM69B ^@ http://purl.uniprot.org/uniprot/U3JG58 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DIPK family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:CPNE2 ^@ http://purl.uniprot.org/uniprot/U3JX01 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/59894:CLCN4 ^@ http://purl.uniprot.org/uniprot/A0A803VJZ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/59894:SLC25A44 ^@ http://purl.uniprot.org/uniprot/U3JIS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:ESCO1 ^@ http://purl.uniprot.org/uniprot/U3JUH9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101812848 ^@ http://purl.uniprot.org/uniprot/U3JWL3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GSPT1 ^@ http://purl.uniprot.org/uniprot/U3JMP0 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily. http://togogenome.org/gene/59894:ESRRB ^@ http://purl.uniprot.org/uniprot/A0A803V803 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/59894:P2RY4 ^@ http://purl.uniprot.org/uniprot/U3KKM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101820645 ^@ http://purl.uniprot.org/uniprot/A0A803V285 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GTF2H2 family.|||Nucleus http://togogenome.org/gene/59894:KPNA7 ^@ http://purl.uniprot.org/uniprot/U3KHB8 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:UBLCP1 ^@ http://purl.uniprot.org/uniprot/U3K1G6 ^@ Function|||Subcellular Location Annotation ^@ Dephosphorylates 26S nuclear proteasomes, thereby decreasing their proteolytic activity. The dephosphorylation may prevent assembly of the core and regulatory particles (CP and RP) into mature 26S proteasome.|||Nucleus http://togogenome.org/gene/59894:DMGDH ^@ http://purl.uniprot.org/uniprot/U3K5S2 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/59894:G6PC ^@ http://purl.uniprot.org/uniprot/U3JDC0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucose-6-phosphatase family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:NCLN ^@ http://purl.uniprot.org/uniprot/A0A803W8V5 ^@ Function|||Similarity ^@ Belongs to the nicastrin family.|||May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning. http://togogenome.org/gene/59894:ING1 ^@ http://purl.uniprot.org/uniprot/U3JP61 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/59894:WDPCP ^@ http://purl.uniprot.org/uniprot/U3KGN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat fritz family.|||Cell membrane|||Membrane|||cilium axoneme http://togogenome.org/gene/59894:LOC101818597 ^@ http://purl.uniprot.org/uniprot/U3KKX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:FRG1 ^@ http://purl.uniprot.org/uniprot/U3K9N0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FRG1 family.|||Cajal body|||nucleolus http://togogenome.org/gene/59894:ADCY2 ^@ http://purl.uniprot.org/uniprot/U3JXI1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59894:LOC101820325 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:LOC101809625 ^@ http://purl.uniprot.org/uniprot/A0A803VSS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the argonaute family.|||P-body http://togogenome.org/gene/59894:NUP205 ^@ http://purl.uniprot.org/uniprot/A0A803V6H2|||http://purl.uniprot.org/uniprot/U3K9F1 ^@ Similarity ^@ Belongs to the NUP186/NUP192/NUP205 family. http://togogenome.org/gene/59894:GABRR3 ^@ http://purl.uniprot.org/uniprot/A0A803W4C9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:PRKCA ^@ http://purl.uniprot.org/uniprot/A0A803V4T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cell membrane|||Cytoplasm|||Membrane|||Mitochondrion membrane|||Nucleus http://togogenome.org/gene/59894:LCAT ^@ http://purl.uniprot.org/uniprot/U3JXA9 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:EIF2B1 ^@ http://purl.uniprot.org/uniprot/A0A803WAZ8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eIF-2B alpha/beta/delta subunits family.|||Catalyzes the exchange of eukaryotic initiation factor 2-bound GDP for GTP.|||Complex of five different subunits; alpha, beta, gamma, delta and epsilon. http://togogenome.org/gene/59894:CHPF ^@ http://purl.uniprot.org/uniprot/U3JNX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:ETFA ^@ http://purl.uniprot.org/uniprot/A0A803VML8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ETF alpha-subunit/FixB family.|||Binds 1 FAD per dimer.|||Heterodimer of an alpha and a beta subunit.|||Mitochondrion matrix|||The electron transfer flavoprotein serves as a specific electron acceptor for several dehydrogenases, including five acyl-CoA dehydrogenases, glutaryl-CoA and sarcosine dehydrogenase. It transfers the electrons to the main mitochondrial respiratory chain via ETF-ubiquinone oxidoreductase (ETF dehydrogenase). http://togogenome.org/gene/59894:THSD1 ^@ http://purl.uniprot.org/uniprot/U3K1M2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the plasmodium circumsporozoite protein family.|||Cell membrane|||Cytoplasm|||In the vertebrate host, binds to highly sulfated heparan sulfate proteoglycans (HSPGs) on the surface of host hepatocytes and is required for sporozoite invasion of the host hepatocytes.|||Membrane http://togogenome.org/gene/59894:LACC1 ^@ http://purl.uniprot.org/uniprot/U3K0C8 ^@ Similarity ^@ Belongs to the purine nucleoside phosphorylase YfiH/LACC1 family. http://togogenome.org/gene/59894:DHX8 ^@ http://purl.uniprot.org/uniprot/U3JDI3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ORM2 ^@ http://purl.uniprot.org/uniprot/U3JEZ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Lipocalin family. Highly divergent.|||Interacts with LRP2; LRP2 mediates APOM renal uptake and subsequent lysosomal degradation.|||Probably involved in lipid transport. Can bind sphingosine-1-phosphate, myristic acid, palmitic acid and stearic acid, retinol, all-trans-retinoic acid and 9-cis-retinoic acid.|||Secreted http://togogenome.org/gene/59894:SOX11 ^@ http://purl.uniprot.org/uniprot/U3KJG5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:KDM3A ^@ http://purl.uniprot.org/uniprot/U3K6B6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CX3CR1 ^@ http://purl.uniprot.org/uniprot/U3KIU0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:IL17REL ^@ http://purl.uniprot.org/uniprot/U3K4W9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:UVSSA ^@ http://purl.uniprot.org/uniprot/U3K605 ^@ Similarity ^@ Belongs to the UVSSA family. http://togogenome.org/gene/59894:TTC26 ^@ http://purl.uniprot.org/uniprot/U3KAP2 ^@ Similarity ^@ Belongs to the IFT56 family. http://togogenome.org/gene/59894:CENPM ^@ http://purl.uniprot.org/uniprot/U3KB97 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MRPS7 ^@ http://purl.uniprot.org/uniprot/U3JEK3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS7 family. http://togogenome.org/gene/59894:NIT2 ^@ http://purl.uniprot.org/uniprot/U3JTN4 ^@ Similarity ^@ Belongs to the carbon-nitrogen hydrolase superfamily. NIT1/NIT2 family. http://togogenome.org/gene/59894:MGMT ^@ http://purl.uniprot.org/uniprot/U3JEQ5 ^@ Function|||Similarity ^@ Belongs to the MGMT family.|||Involved in the cellular defense against the biological effects of O6-methylguanine (O6-MeG) and O4-methylthymine (O4-MeT) in DNA. Repairs the methylated nucleobase in DNA by stoichiometrically transferring the methyl group to a cysteine residue in the enzyme. This is a suicide reaction: the enzyme is irreversibly inactivated. http://togogenome.org/gene/59894:MANBA ^@ http://purl.uniprot.org/uniprot/U3K0F4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 2 family.|||Exoglycosidase that cleaves the single beta-linked mannose residue from the non-reducing end of all N-linked glycoprotein oligosaccharides.|||Lysosome|||Monomer. http://togogenome.org/gene/59894:PLBD1 ^@ http://purl.uniprot.org/uniprot/U3KAF2 ^@ Function|||Similarity ^@ Belongs to the phospholipase B-like family.|||Putative phospholipase. http://togogenome.org/gene/59894:MMP24 ^@ http://purl.uniprot.org/uniprot/A0A803WH20|||http://purl.uniprot.org/uniprot/U3KD76 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/59894:PRIM2 ^@ http://purl.uniprot.org/uniprot/U3JG70 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the eukaryotic-type primase large subunit family.|||Binds 1 [4Fe-4S] cluster.|||Regulatory subunit of the DNA primase complex and component of the DNA polymerase alpha complex (also known as the alpha DNA polymerase-primase complex) which play an essential role in the initiation of DNA synthesis. The primase subunit of the polymerase alpha complex initiates DNA synthesis by oligomerising short RNA primers on both leading and lagging strands. http://togogenome.org/gene/59894:LOC101805774 ^@ http://purl.uniprot.org/uniprot/U3JGF7 ^@ Caution|||Function|||Subunit ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Non-covalent dimer of an alpha and a beta subunit. IL2R exists in 3 different forms: a high affinity dimer, an intermediate affinity monomer (beta subunit), and a low affinity monomer (alpha subunit). The high and intermediate affinity forms also associate with a gamma subunit.|||Receptor for interleukin-2. The receptor is involved in the regulation of immune tolerance by controlling regulatory T cells (TREGs) activity. TREGs suppress the activation and expansion of autoreactive T-cells. http://togogenome.org/gene/59894:ATP6V1H ^@ http://purl.uniprot.org/uniprot/U3K6J2 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase H subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59894:NPNT ^@ http://purl.uniprot.org/uniprot/A0A803V555|||http://purl.uniprot.org/uniprot/U3KD20 ^@ Caution|||Similarity ^@ Belongs to the nephronectin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CALCA ^@ http://purl.uniprot.org/uniprot/A0A803W094 ^@ Similarity ^@ Belongs to the calcitonin family. http://togogenome.org/gene/59894:CYLD ^@ http://purl.uniprot.org/uniprot/A0A803WEP9|||http://purl.uniprot.org/uniprot/U3JBC7 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||centrosome|||cilium basal body|||perinuclear region|||spindle http://togogenome.org/gene/59894:EEF2 ^@ http://purl.uniprot.org/uniprot/U3JDP2 ^@ Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-G/EF-2 subfamily. http://togogenome.org/gene/59894:MGAT5 ^@ http://purl.uniprot.org/uniprot/U3KH16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 18 family.|||Golgi apparatus membrane|||Membrane|||Secreted http://togogenome.org/gene/59894:HOXD13 ^@ http://purl.uniprot.org/uniprot/U3JKE1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PER2 ^@ http://purl.uniprot.org/uniprot/U3JN88 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CSGALNACT2 ^@ http://purl.uniprot.org/uniprot/U3JWM0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:N6AMT1 ^@ http://purl.uniprot.org/uniprot/A0A803VLL9 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal PrmC-related family. http://togogenome.org/gene/59894:CASQ2 ^@ http://purl.uniprot.org/uniprot/U3JUA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the calsequestrin family.|||Calsequestrin is a high-capacity, moderate affinity, calcium-binding protein and thus acts as an internal calcium store in muscle.|||Sarcoplasmic reticulum lumen http://togogenome.org/gene/59894:EXOC3L1 ^@ http://purl.uniprot.org/uniprot/U3JX77 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/59894:LPAR6 ^@ http://purl.uniprot.org/uniprot/A0A803VY78 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:HMGA2 ^@ http://purl.uniprot.org/uniprot/U3K5Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGA family.|||Nucleus http://togogenome.org/gene/59894:CFI ^@ http://purl.uniprot.org/uniprot/U3JVB4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:UHRF2 ^@ http://purl.uniprot.org/uniprot/U3K7R8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101821869 ^@ http://purl.uniprot.org/uniprot/U3JWT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the reduced folate carrier (RFC) transporter (TC 2.A.48) family.|||Membrane http://togogenome.org/gene/59894:SLCO2A1 ^@ http://purl.uniprot.org/uniprot/A0A803VTE6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:EXTL3 ^@ http://purl.uniprot.org/uniprot/U3K8E7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:LOC101818785 ^@ http://purl.uniprot.org/uniprot/U3KCP2 ^@ Similarity ^@ Belongs to the glycine N-acyltransferase family. http://togogenome.org/gene/59894:GPATCH1 ^@ http://purl.uniprot.org/uniprot/U3JZF4 ^@ Similarity ^@ Belongs to the GPATCH1 family. http://togogenome.org/gene/59894:LOC101810269 ^@ http://purl.uniprot.org/uniprot/U3KB61 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59894:PIGN ^@ http://purl.uniprot.org/uniprot/A0A803WA42 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.|||Endoplasmic reticulum membrane|||Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor.|||Membrane http://togogenome.org/gene/59894:RMND1 ^@ http://purl.uniprot.org/uniprot/U3KCP9 ^@ Similarity ^@ Belongs to the RMD1/sif2 family. http://togogenome.org/gene/59894:WNT7B ^@ http://purl.uniprot.org/uniprot/A0A803VW64|||http://purl.uniprot.org/uniprot/U3JJL1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:ADCY1 ^@ http://purl.uniprot.org/uniprot/U3KFJ1 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59894:ALG10B ^@ http://purl.uniprot.org/uniprot/U3K626 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG10 glucosyltransferase family.|||Membrane http://togogenome.org/gene/59894:ERG ^@ http://purl.uniprot.org/uniprot/A0A803V891|||http://purl.uniprot.org/uniprot/A0A803VJR2|||http://purl.uniprot.org/uniprot/U3JRA3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:DDR2 ^@ http://purl.uniprot.org/uniprot/U3JLM1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SDAD1 ^@ http://purl.uniprot.org/uniprot/U3K166 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SDA1 family.|||Required for 60S pre-ribosomal subunits export to the cytoplasm.|||nucleolus http://togogenome.org/gene/59894:GNB1 ^@ http://purl.uniprot.org/uniprot/U3K477 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/59894:GALT ^@ http://purl.uniprot.org/uniprot/U3K5D7 ^@ Cofactor|||Similarity ^@ Belongs to the galactose-1-phosphate uridylyltransferase type 1 family.|||Binds 1 Fe cation per subunit. http://togogenome.org/gene/59894:IBSP ^@ http://purl.uniprot.org/uniprot/U3JR86 ^@ Function|||Subcellular Location Annotation ^@ Binds tightly to hydroxyapatite. Appears to form an integral part of the mineralized matrix. Probably important to cell-matrix interaction. Promotes Arg-Gly-Asp-dependent cell attachment.|||Secreted http://togogenome.org/gene/59894:SOX10 ^@ http://purl.uniprot.org/uniprot/U3KE06 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MDM2 ^@ http://purl.uniprot.org/uniprot/U3K6C0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MDM2/MDM4 family.|||Cytoplasm|||nucleolus|||nucleoplasm http://togogenome.org/gene/59894:C11H16orf70 ^@ http://purl.uniprot.org/uniprot/U3JYT2 ^@ Similarity ^@ Belongs to the PHAF1 family. http://togogenome.org/gene/59894:NSMCE4A ^@ http://purl.uniprot.org/uniprot/A0A803V3Q4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE4 family.|||Component of the SMC5-SMC6 complex, that promotes sister chromatid alignment after DNA damage and facilitates double-stranded DNA breaks (DSBs) repair via homologous recombination between sister chromatids.|||Component of the SMC5-SMC6 complex.|||Nucleus|||telomere http://togogenome.org/gene/59894:NDC80 ^@ http://purl.uniprot.org/uniprot/U3JUT9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the NDC80/HEC1 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/59894:HS3ST5 ^@ http://purl.uniprot.org/uniprot/U3K8V3 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:RARS2 ^@ http://purl.uniprot.org/uniprot/U3JJV3 ^@ Similarity ^@ Belongs to the class-I aminoacyl-tRNA synthetase family. http://togogenome.org/gene/59894:COQ5 ^@ http://purl.uniprot.org/uniprot/A0A803VSK9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. MenG/UbiE family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Methyltransferase required for the conversion of 2-polyprenyl-6-methoxy-1,4-benzoquinol (DDMQH2) to 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2).|||Mitochondrion inner membrane http://togogenome.org/gene/59894:MMGT1 ^@ http://purl.uniprot.org/uniprot/U3JNY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane magnesium transporter (TC 1.A.67) family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Membrane|||Part of the endoplasmic reticulum membrane protein complex (EMC) that enables the energy-independent insertion into endoplasmic reticulum membranes of newly synthesized membrane proteins. May be involved in Mg(2+) transport. http://togogenome.org/gene/59894:LOC101822060 ^@ http://purl.uniprot.org/uniprot/A0A803WBT7|||http://purl.uniprot.org/uniprot/U3JRV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A9 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:EIF4ENIF1 ^@ http://purl.uniprot.org/uniprot/U3JYA1 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ISCA1 ^@ http://purl.uniprot.org/uniprot/A0A803VC20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HesB/IscA family.|||Mitochondrion http://togogenome.org/gene/59894:ND2 ^@ http://purl.uniprot.org/uniprot/S0AU78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 2 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:HGD ^@ http://purl.uniprot.org/uniprot/U3JRW5 ^@ Similarity ^@ Belongs to the homogentisate dioxygenase family. http://togogenome.org/gene/59894:STMN2 ^@ http://purl.uniprot.org/uniprot/U3K1R7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the stathmin family.|||Cytoplasm|||Membrane|||lamellipodium http://togogenome.org/gene/59894:C15H12orf65 ^@ http://purl.uniprot.org/uniprot/U3K3Q1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prokaryotic/mitochondrial release factor family.|||Mitochondrion http://togogenome.org/gene/59894:CREBL2 ^@ http://purl.uniprot.org/uniprot/A0A803VRV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Nucleus http://togogenome.org/gene/59894:GPBP1 ^@ http://purl.uniprot.org/uniprot/A0A803VFL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/59894:NHSL1 ^@ http://purl.uniprot.org/uniprot/A0A803V160|||http://purl.uniprot.org/uniprot/A0A803VFB3|||http://purl.uniprot.org/uniprot/U3KEE3 ^@ Similarity ^@ Belongs to the NHS family. http://togogenome.org/gene/59894:RCAN3 ^@ http://purl.uniprot.org/uniprot/U3JCJ3 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/59894:LOC101809742 ^@ http://purl.uniprot.org/uniprot/U3KC17 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/59894:CHRNA9 ^@ http://purl.uniprot.org/uniprot/U3JJM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:COPS7B ^@ http://purl.uniprot.org/uniprot/U3JYV8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN7/EIF3M family. CSN7 subfamily.|||Component of the COP9 signalosome complex (CSN), a complex involved in various cellular and developmental processes. The CSN complex is an essential regulator of the ubiquitin (Ubl) conjugation pathway by mediating the deneddylation of the cullin subunits of SCF-type E3 ligase complexes, leading to decrease the Ubl ligase activity of SCF-type complexes such as SCF, CSA or DDB2. The complex is also involved in phosphorylation of p53/TP53, JUN, I-kappa-B-alpha/NFKBIA, ITPK1 and IRF8/ICSBP, possibly via its association with CK2 and PKD kinases. CSN-dependent phosphorylation of TP53 and JUN promotes and protects degradation by the Ubl system, respectively.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:LOC101810239 ^@ http://purl.uniprot.org/uniprot/U3JHT2 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:RPL26L1 ^@ http://purl.uniprot.org/uniprot/U3K2E2 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL24 family. http://togogenome.org/gene/59894:MFSD11 ^@ http://purl.uniprot.org/uniprot/U3JDN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-93 family.|||Membrane http://togogenome.org/gene/59894:RTFDC1 ^@ http://purl.uniprot.org/uniprot/U3K8K4 ^@ Similarity ^@ Belongs to the rtf2 family. http://togogenome.org/gene/59894:SPPL3 ^@ http://purl.uniprot.org/uniprot/A0A803WB13 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A22B family.|||Membrane http://togogenome.org/gene/59894:OAZ2 ^@ http://purl.uniprot.org/uniprot/U3K5E6 ^@ Similarity ^@ Belongs to the ODC antizyme family. http://togogenome.org/gene/59894:SFXN1 ^@ http://purl.uniprot.org/uniprot/A0A803VZ39 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:POLR2C ^@ http://purl.uniprot.org/uniprot/A0A803V4P0 ^@ Similarity ^@ Belongs to the archaeal Rpo3/eukaryotic RPB3 RNA polymerase subunit family. http://togogenome.org/gene/59894:FBXO32 ^@ http://purl.uniprot.org/uniprot/U3JIG4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TMEM177 ^@ http://purl.uniprot.org/uniprot/U3KI53 ^@ Function|||Similarity ^@ Belongs to the TMEM177 family.|||Plays a role in the early steps of cytochrome c oxidase subunit II (MT-CO2/COX2) maturation and is required for the stabilization of COX20 and the newly synthesized MT-CO2/COX2 protein. http://togogenome.org/gene/59894:POP5 ^@ http://purl.uniprot.org/uniprot/A0A803VBM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic/archaeal RNase P protein component 2 family.|||Component of ribonuclease P, a protein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/59894:FAM149A ^@ http://purl.uniprot.org/uniprot/U3KBS5 ^@ Similarity ^@ Belongs to the FAM149 family. http://togogenome.org/gene/59894:TMEM59 ^@ http://purl.uniprot.org/uniprot/U3KBZ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM59 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:ING5 ^@ http://purl.uniprot.org/uniprot/A0A803V9L3 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ING family.|||Component of an histone acetyltransferase complex.|||Component of an histone acetyltransferase complex. Interacts with H3K4me3 and to a lesser extent with H3K4me2.|||Nucleus|||The PHD-type zinc finger mediates the binding to H3K4me3. http://togogenome.org/gene/59894:LPAR4 ^@ http://purl.uniprot.org/uniprot/U3KKI4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:LOC101819804 ^@ http://purl.uniprot.org/uniprot/A0A803VSE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ELO family.|||Membrane http://togogenome.org/gene/59894:LOC101812909 ^@ http://purl.uniprot.org/uniprot/A0A803VZD0 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:NPRL2 ^@ http://purl.uniprot.org/uniprot/U3K2Y5 ^@ Similarity ^@ Belongs to the NPR2 family. http://togogenome.org/gene/59894:LOC101817769 ^@ http://purl.uniprot.org/uniprot/U3JNL1 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:SLC1A3 ^@ http://purl.uniprot.org/uniprot/U3JH88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59894:ACER3 ^@ http://purl.uniprot.org/uniprot/U3JYN6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/59894:LOC101815406 ^@ http://purl.uniprot.org/uniprot/U3KFI5 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers.|||Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. http://togogenome.org/gene/59894:NAP1L4 ^@ http://purl.uniprot.org/uniprot/U3KA74 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/59894:ASIP ^@ http://purl.uniprot.org/uniprot/A0A803VWB4 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:EXOC3L4 ^@ http://purl.uniprot.org/uniprot/U3JJG1 ^@ Similarity ^@ Belongs to the SEC6 family. http://togogenome.org/gene/59894:WDR24 ^@ http://purl.uniprot.org/uniprot/U3JPR5 ^@ Similarity ^@ Belongs to the WD repeat WDR24 family. http://togogenome.org/gene/59894:F2 ^@ http://purl.uniprot.org/uniprot/A0A803VHB2|||http://purl.uniprot.org/uniprot/U3JUU7 ^@ Caution|||Function|||Similarity ^@ Belongs to the peptidase S1 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing. http://togogenome.org/gene/59894:TAGLN3 ^@ http://purl.uniprot.org/uniprot/U3JV09 ^@ Similarity ^@ Belongs to the calponin family. http://togogenome.org/gene/59894:BDNF ^@ http://purl.uniprot.org/uniprot/A0A803V5M5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NGF-beta family.|||Promotes the survival of neuronal populations that are all located either in the central nervous system or directly connected to it.|||Secreted http://togogenome.org/gene/59894:GNG12 ^@ http://purl.uniprot.org/uniprot/U3KEP4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/59894:SRP9 ^@ http://purl.uniprot.org/uniprot/A0A803V9W5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SRP9 family.|||Component of the signal recognition particle (SRP) complex, a ribonucleoprotein complex that mediates the cotranslational targeting of secretory and membrane proteins to the endoplasmic reticulum (ER). SRP9 together with SRP14 and the Alu portion of the SRP RNA, constitutes the elongation arrest domain of SRP. The complex of SRP9 and SRP14 is required for SRP RNA binding.|||Cytoplasm http://togogenome.org/gene/59894:RPL9 ^@ http://purl.uniprot.org/uniprot/A0A803WC21|||http://purl.uniprot.org/uniprot/U3K3P6 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL6 family. http://togogenome.org/gene/59894:SPNS3 ^@ http://purl.uniprot.org/uniprot/U3JXH4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Spinster (TC 2.A.1.49) family.|||Membrane http://togogenome.org/gene/59894:MAP1LC3C ^@ http://purl.uniprot.org/uniprot/U3KFA5 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59894:NEUROD1 ^@ http://purl.uniprot.org/uniprot/U3KLI5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ASUN ^@ http://purl.uniprot.org/uniprot/U3JMS1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the asunder family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CEP76 ^@ http://purl.uniprot.org/uniprot/U3JVD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CEP76 family.|||Centrosomal protein involved in regulation of centriole duplication. Required to limit centriole duplication to once per cell cycle by preventing centriole reduplication.|||centriole http://togogenome.org/gene/59894:CSNK1A1 ^@ http://purl.uniprot.org/uniprot/A0A803VHX7|||http://purl.uniprot.org/uniprot/A0A803W380 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:SNCG ^@ http://purl.uniprot.org/uniprot/U3JW34 ^@ Similarity|||Subunit ^@ Belongs to the synuclein family.|||May be a centrosome-associated protein. Interacts with MYOC; affects its secretion and its aggregation. http://togogenome.org/gene/59894:MCOLN3 ^@ http://purl.uniprot.org/uniprot/U3JUJ5 ^@ Subcellular Location Annotation ^@ Endosome membrane|||Membrane http://togogenome.org/gene/59894:RAB14 ^@ http://purl.uniprot.org/uniprot/A0A803VJ64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Early endosome membrane|||Endosome membrane|||Golgi apparatus membrane|||Recycling endosome|||phagosome|||trans-Golgi network membrane http://togogenome.org/gene/59894:RNASEH2B ^@ http://purl.uniprot.org/uniprot/A0A803VWS3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNase H2 subunit B family.|||Non catalytic subunit of RNase H2, an endonuclease that specifically degrades the RNA of RNA:DNA hybrids. Participates in DNA replication, possibly by mediating the removal of lagging-strand Okazaki fragment RNA primers during DNA replication. Mediates the excision of single ribonucleotides from DNA:RNA duplexes.|||Nucleus|||The RNase H2 complex is a heterotrimer composed of the catalytic subunit RNASEH2A and the non-catalytic subunits RNASEH2B and RNASEH2C. http://togogenome.org/gene/59894:SLF2 ^@ http://purl.uniprot.org/uniprot/U3K203 ^@ Similarity ^@ Belongs to the FAM178 family. http://togogenome.org/gene/59894:LOC101808562 ^@ http://purl.uniprot.org/uniprot/A0A803V7G0 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/59894:NOTUM ^@ http://purl.uniprot.org/uniprot/U3KBF2 ^@ Similarity ^@ Belongs to the pectinacetylesterase family. Notum subfamily. http://togogenome.org/gene/59894:FPGS ^@ http://purl.uniprot.org/uniprot/U3JF34 ^@ Cofactor|||Function|||Similarity ^@ A monovalent cation.|||Belongs to the folylpolyglutamate synthase family.|||Catalyzes conversion of folates to polyglutamate derivatives allowing concentration of folate compounds in the cell and the intracellular retention of these cofactors, which are important substrates for most of the folate-dependent enzymes that are involved in one-carbon transfer reactions involved in purine, pyrimidine and amino acid synthesis. http://togogenome.org/gene/59894:BIVM ^@ http://purl.uniprot.org/uniprot/U3JNQ3 ^@ Similarity ^@ Belongs to the BIVM family. http://togogenome.org/gene/59894:NME3 ^@ http://purl.uniprot.org/uniprot/A0A803VKJ7 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59894:PLN ^@ http://purl.uniprot.org/uniprot/U3KLJ5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phospholamban family.|||Endoplasmic reticulum membrane|||Homopentamer.|||Membrane|||Mitochondrion membrane|||Reversibly inhibits the activity of ATP2A2 in cardiac sarcoplasmic reticulum by decreasing the apparent affinity of the ATPase for Ca(2+). Modulates the contractility of the heart muscle in response to physiological stimuli via its effects on ATP2A2. Modulates calcium re-uptake during muscle relaxation and plays an important role in calcium homeostasis in the heart muscle. The degree of ATP2A2 inhibition depends on the oligomeric state of PLN.|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/59894:METTL6 ^@ http://purl.uniprot.org/uniprot/U3K387 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. METL family. http://togogenome.org/gene/59894:PGPEP1L ^@ http://purl.uniprot.org/uniprot/U3K6Z0 ^@ Similarity ^@ Belongs to the peptidase C15 family. http://togogenome.org/gene/59894:ELAVL1 ^@ http://purl.uniprot.org/uniprot/U3KB36 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm http://togogenome.org/gene/59894:MRPS14 ^@ http://purl.uniprot.org/uniprot/U3K160 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS14 family. http://togogenome.org/gene/59894:GSTZ1 ^@ http://purl.uniprot.org/uniprot/U3KE46 ^@ Similarity ^@ Belongs to the GST superfamily. Zeta family. http://togogenome.org/gene/59894:HARBI1 ^@ http://purl.uniprot.org/uniprot/A0A803VN74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HARBI1 family.|||Cytoplasm|||Nucleus|||Transposase-derived protein that may have nuclease activity (Potential). Does not have transposase activity. http://togogenome.org/gene/59894:BNIP1 ^@ http://purl.uniprot.org/uniprot/U3K2D9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DYRK3 ^@ http://purl.uniprot.org/uniprot/U3JCS8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MNB/DYRK subfamily. http://togogenome.org/gene/59894:MAK16 ^@ http://purl.uniprot.org/uniprot/U3JWG5 ^@ Similarity ^@ Belongs to the MAK16 family. http://togogenome.org/gene/59894:TDRD7 ^@ http://purl.uniprot.org/uniprot/U3JEL9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:TUBD1 ^@ http://purl.uniprot.org/uniprot/U3JSN7 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Nucleus|||centriole|||cilium http://togogenome.org/gene/59894:LOC101813722 ^@ http://purl.uniprot.org/uniprot/U3JXR8 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/59894:WDR48 ^@ http://purl.uniprot.org/uniprot/U3JW27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat WDR48 family.|||Endosome|||Late endosome http://togogenome.org/gene/59894:SH3GL3 ^@ http://purl.uniprot.org/uniprot/U3K9B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Early endosome membrane|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:SCUBE1 ^@ http://purl.uniprot.org/uniprot/U3JVY5 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:PROX2 ^@ http://purl.uniprot.org/uniprot/U3JUY1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ATP6V0C ^@ http://purl.uniprot.org/uniprot/A0A803V9I5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase proteolipid subunit family.|||Membrane|||Proton-conducting pore forming of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and the accessory subunits.|||Vacuole membrane|||clathrin-coated vesicle membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:SLC7A9 ^@ http://purl.uniprot.org/uniprot/U3JBY8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LPAR3 ^@ http://purl.uniprot.org/uniprot/U3JUJ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NDRG3 ^@ http://purl.uniprot.org/uniprot/A0A803VK75|||http://purl.uniprot.org/uniprot/U3KDJ9 ^@ Similarity ^@ Belongs to the NDRG family. http://togogenome.org/gene/59894:TSSC4 ^@ http://purl.uniprot.org/uniprot/U3KJ65 ^@ Similarity ^@ Belongs to the TSSC4 family. http://togogenome.org/gene/59894:ASCC3 ^@ http://purl.uniprot.org/uniprot/U3JRS3 ^@ Similarity ^@ Belongs to the helicase family. SKI2 subfamily. http://togogenome.org/gene/59894:LOC101808355 ^@ http://purl.uniprot.org/uniprot/U3JPS8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:HACL1 ^@ http://purl.uniprot.org/uniprot/U3K3S4 ^@ Similarity ^@ Belongs to the TPP enzyme family. http://togogenome.org/gene/59894:BPI ^@ http://purl.uniprot.org/uniprot/U3JRQ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Cytoplasmic granule membrane|||Membrane|||Monomer. Homodimer; disulfide-linked.|||Secreted|||The N- and C-terminal barrels adopt an identical fold despite having only 13% of conserved residues.|||The N-terminal region may be exposed to the interior of the granule, whereas the C-terminal portion may be embedded in the membrane. During phagocytosis and degranulation, proteases may be released and activated and cleave BPI at the junction of the N- and C-terminal portions of the molecule, providing controlled release of the N-terminal antibacterial fragment when bacteria are ingested.|||The cytotoxic action of BPI is limited to many species of Gram-negative bacteria; this specificity may be explained by a strong affinity of the very basic N-terminal half for the negatively charged lipopolysaccharides that are unique to the Gram-negative bacterial outer envelope. http://togogenome.org/gene/59894:TIPARP ^@ http://purl.uniprot.org/uniprot/U3JQC1 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/59894:SPARC ^@ http://purl.uniprot.org/uniprot/U3K0N4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Appears to regulate cell growth through interactions with the extracellular matrix and cytokines. Binds calcium and copper, several types of collagen, albumin, thrombospondin, PDGF and cell membranes. There are two calcium binding sites; an acidic domain that binds 5 to 8 Ca(2+) with a low affinity and an EF-hand loop that binds a Ca(2+) ion with a high affinity.|||Belongs to the SPARC family.|||Membrane|||basement membrane http://togogenome.org/gene/59894:TADA3 ^@ http://purl.uniprot.org/uniprot/U3KEQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NGG1 family.|||Nucleus http://togogenome.org/gene/59894:BCAR1 ^@ http://purl.uniprot.org/uniprot/U3JYF4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAS family.|||focal adhesion http://togogenome.org/gene/59894:SPC25 ^@ http://purl.uniprot.org/uniprot/A0A803W1H2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a component of the essential kinetochore-associated NDC80 complex, which is required for chromosome segregation and spindle checkpoint activity.|||Belongs to the SPC25 family.|||Component of the NDC80 complex.|||Nucleus|||kinetochore http://togogenome.org/gene/59894:INTS8 ^@ http://purl.uniprot.org/uniprot/U3JSM5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 8 family.|||Nucleus http://togogenome.org/gene/59894:SLC20A1 ^@ http://purl.uniprot.org/uniprot/U3JBA4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/59894:MYO1D ^@ http://purl.uniprot.org/uniprot/A0A803VG27 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:MVK ^@ http://purl.uniprot.org/uniprot/U3K254 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GHMP kinase family. Mevalonate kinase subfamily.|||Catalyzes the phosphorylation of mevalonate to mevalonate 5-phosphate, a key step in isoprenoid and cholesterol biosynthesis.|||Cytoplasm http://togogenome.org/gene/59894:B3GNT7 ^@ http://purl.uniprot.org/uniprot/U3KLK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:DHDDS ^@ http://purl.uniprot.org/uniprot/A0A803VU61 ^@ Similarity ^@ Belongs to the UPP synthase family. http://togogenome.org/gene/59894:CDR2L ^@ http://purl.uniprot.org/uniprot/U3JEU3 ^@ Similarity ^@ Belongs to the CDR2 family. http://togogenome.org/gene/59894:CCDC85A ^@ http://purl.uniprot.org/uniprot/A0A803VPD2|||http://purl.uniprot.org/uniprot/U3K9H9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/59894:ANKLE2 ^@ http://purl.uniprot.org/uniprot/U3K0K7 ^@ Similarity ^@ Belongs to the ANKLE2 family. http://togogenome.org/gene/59894:NFKB1 ^@ http://purl.uniprot.org/uniprot/U3K0E6 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:DDX5 ^@ http://purl.uniprot.org/uniprot/U3JI17 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX5/DBP2 subfamily. http://togogenome.org/gene/59894:LOC101820998 ^@ http://purl.uniprot.org/uniprot/A0A803VMV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/59894:FAM49A ^@ http://purl.uniprot.org/uniprot/A0A803V9N4|||http://purl.uniprot.org/uniprot/A0A803W574|||http://purl.uniprot.org/uniprot/U3K209|||http://purl.uniprot.org/uniprot/U3K210 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CYRI family.|||Membrane http://togogenome.org/gene/59894:SLC25A15 ^@ http://purl.uniprot.org/uniprot/U3K1Q5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:SLC46A2 ^@ http://purl.uniprot.org/uniprot/U3JBG8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101821017 ^@ http://purl.uniprot.org/uniprot/U3JPE6 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/59894:CLDN12 ^@ http://purl.uniprot.org/uniprot/U3KJ86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Membrane|||tight junction http://togogenome.org/gene/59894:LOC101821752 ^@ http://purl.uniprot.org/uniprot/A0A803W1C1 ^@ Similarity ^@ Belongs to the CDP-alcohol phosphatidyltransferase class-I family. http://togogenome.org/gene/59894:SLC4A3 ^@ http://purl.uniprot.org/uniprot/U3JP30 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Membrane http://togogenome.org/gene/59894:HOXD10 ^@ http://purl.uniprot.org/uniprot/U3JKG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59894:HTR2C ^@ http://purl.uniprot.org/uniprot/A0A803VM86 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MPDZ. Interacts with ARRB2.|||Membrane http://togogenome.org/gene/59894:KLHL40 ^@ http://purl.uniprot.org/uniprot/A0A803VH08 ^@ Similarity|||Subcellular Location Annotation ^@ A band|||Belongs to the KLHL40 family.|||I band http://togogenome.org/gene/59894:FOXS1 ^@ http://purl.uniprot.org/uniprot/A0A803VK37 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:GINS4 ^@ http://purl.uniprot.org/uniprot/A0A803WC57 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GINS4/SLD5 family.|||Chromosome|||Nucleus|||Required for initiation of chromosomal DNA replication. Core component of CDC45-MCM-GINS (CMG) helicase, the molecular machine that unwinds template DNA during replication, and around which the replisome is built. http://togogenome.org/gene/59894:WT1 ^@ http://purl.uniprot.org/uniprot/A0A803V9F4|||http://purl.uniprot.org/uniprot/A0A803W5R8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EGR C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus speckle http://togogenome.org/gene/59894:CLDN1 ^@ http://purl.uniprot.org/uniprot/A0A803VS81 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:YPEL1 ^@ http://purl.uniprot.org/uniprot/A0A803W4Z4 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/59894:TMEM163 ^@ http://purl.uniprot.org/uniprot/U3KH17 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM163 family.|||Early endosome membrane|||Endosome membrane|||May bind zinc and other divalent cations and recruit them to vesicular organelles.|||Membrane|||synaptic vesicle membrane http://togogenome.org/gene/59894:APLP2 ^@ http://purl.uniprot.org/uniprot/A0A803V1L5|||http://purl.uniprot.org/uniprot/A0A803VJR9|||http://purl.uniprot.org/uniprot/U3JQN8 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the APP family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:GDA ^@ http://purl.uniprot.org/uniprot/U3K852 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. ATZ/TRZ family.|||Binds 1 zinc ion per subunit.|||Catalyzes the hydrolytic deamination of guanine, producing xanthine and ammonia. http://togogenome.org/gene/59894:CNP ^@ http://purl.uniprot.org/uniprot/U3JD02 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the 2H phosphoesterase superfamily. CNPase family.|||Exists as monomers and homodimers.|||Melanosome|||Membrane http://togogenome.org/gene/59894:SVOPL ^@ http://purl.uniprot.org/uniprot/U3K335 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MAN2C1 ^@ http://purl.uniprot.org/uniprot/U3K8B4 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 38 family. http://togogenome.org/gene/59894:SLC17A5 ^@ http://purl.uniprot.org/uniprot/U3JX73 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:AP2B1 ^@ http://purl.uniprot.org/uniprot/A0A803VP36|||http://purl.uniprot.org/uniprot/A0A803WE09|||http://purl.uniprot.org/uniprot/U3K528 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/59894:SLC29A4 ^@ http://purl.uniprot.org/uniprot/U3KHD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/59894:LOC101816058 ^@ http://purl.uniprot.org/uniprot/U3K8N5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DCBLD1 ^@ http://purl.uniprot.org/uniprot/U3K989 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:MED13 ^@ http://purl.uniprot.org/uniprot/U3JSI7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 13 family.|||Component of the Mediator complex, a coactivator involved in regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59894:FLI1 ^@ http://purl.uniprot.org/uniprot/A0A803VL10 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:LOC101819248 ^@ http://purl.uniprot.org/uniprot/U3KIK7 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:MAPK1IP1L ^@ http://purl.uniprot.org/uniprot/A0A803V293 ^@ Similarity ^@ Belongs to the MISS family. http://togogenome.org/gene/59894:LOC101807147 ^@ http://purl.uniprot.org/uniprot/U3JTF9 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/59894:LMBR1 ^@ http://purl.uniprot.org/uniprot/U3JWP7 ^@ Similarity ^@ Belongs to the LIMR family. http://togogenome.org/gene/59894:SEC22C ^@ http://purl.uniprot.org/uniprot/U3JE30 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||May be involved in vesicle transport between the ER and the Golgi complex.|||Membrane http://togogenome.org/gene/59894:METAP1D ^@ http://purl.uniprot.org/uniprot/A0A803VGL4 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/59894:CTGF ^@ http://purl.uniprot.org/uniprot/U3KB68 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCN family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:GDAP1 ^@ http://purl.uniprot.org/uniprot/A0A803W8K8 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/59894:AGTPBP1 ^@ http://purl.uniprot.org/uniprot/A0A803VJU3|||http://purl.uniprot.org/uniprot/U3JLV1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M14 family.|||cytosol http://togogenome.org/gene/59894:ZHX1 ^@ http://purl.uniprot.org/uniprot/U3KIZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ZHX family.|||Nucleus http://togogenome.org/gene/59894:GALNT15 ^@ http://purl.uniprot.org/uniprot/A0A803V0L9|||http://purl.uniprot.org/uniprot/U3K3R1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:MAL2 ^@ http://purl.uniprot.org/uniprot/A0A803WCL7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MAST2 ^@ http://purl.uniprot.org/uniprot/A0A803W2J5|||http://purl.uniprot.org/uniprot/U3K4H7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/59894:LOC101813221 ^@ http://purl.uniprot.org/uniprot/U3JK79 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:MON1A ^@ http://purl.uniprot.org/uniprot/U3K2V5 ^@ Function|||Similarity ^@ Belongs to the MON1/SAND family.|||Plays an important role in membrane trafficking through the secretory apparatus. http://togogenome.org/gene/59894:LOC101810807 ^@ http://purl.uniprot.org/uniprot/U3JWV1 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/59894:PDE7B ^@ http://purl.uniprot.org/uniprot/A0A803VL79|||http://purl.uniprot.org/uniprot/A0A803VU93 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:TPST1 ^@ http://purl.uniprot.org/uniprot/A0A803VK31|||http://purl.uniprot.org/uniprot/U3JW51 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/59894:VDAC1 ^@ http://purl.uniprot.org/uniprot/U3JZN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic mitochondrial porin family.|||Cell membrane|||Membrane|||Membrane raft http://togogenome.org/gene/59894:FAM76B ^@ http://purl.uniprot.org/uniprot/U3JC39 ^@ Similarity ^@ Belongs to the FAM76 family. http://togogenome.org/gene/59894:KIAA0391 ^@ http://purl.uniprot.org/uniprot/U3JU12 ^@ Similarity ^@ Belongs to the PPR family. P subfamily. http://togogenome.org/gene/59894:TMEM115 ^@ http://purl.uniprot.org/uniprot/U3K2Y3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SET ^@ http://purl.uniprot.org/uniprot/A0A803VMM4 ^@ Similarity ^@ Belongs to the nucleosome assembly protein (NAP) family. http://togogenome.org/gene/59894:NSUN7 ^@ http://purl.uniprot.org/uniprot/U3JJM9 ^@ Caution|||Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GAP43 ^@ http://purl.uniprot.org/uniprot/U3JU27 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the neuromodulin family.|||Binds calmodulin with a greater affinity in the absence of Ca(2+) than in its presence.|||Cell membrane|||Membrane|||Palmitoylated. Palmitoylation is essential for plasma membrane association.|||Synapse|||This protein is associated with nerve growth. It is a major component of the motile 'growth cones' that form the tips of elongating axons. Plays a role in axonal and dendritic filopodia induction.|||filopodium membrane|||growth cone membrane http://togogenome.org/gene/59894:NDST4 ^@ http://purl.uniprot.org/uniprot/U3JEC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 1 family. NDST subfamily.|||Membrane http://togogenome.org/gene/59894:NSMCE1 ^@ http://purl.uniprot.org/uniprot/U3KI27 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NSE1 family.|||Component of the Smc5-Smc6 complex.|||Nucleus|||RING-type zinc finger-containing E3 ubiquitin ligase that assembles with melanoma antigen protein (MAGE) to catalyze the direct transfer of ubiquitin from E2 ubiquitin-conjugating enzyme to a specific substrate. Involved in maintenance of genome integrity, DNA damage response and DNA repair.|||telomere http://togogenome.org/gene/59894:LOC101815822 ^@ http://purl.uniprot.org/uniprot/A0A803V927 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/59894:PDSS2 ^@ http://purl.uniprot.org/uniprot/A0A803VWG6 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/59894:FAM120A ^@ http://purl.uniprot.org/uniprot/A0A803VQM8|||http://purl.uniprot.org/uniprot/U3JX26 ^@ Similarity ^@ Belongs to the constitutive coactivator of PPAR-gamma family. http://togogenome.org/gene/59894:PCSK1 ^@ http://purl.uniprot.org/uniprot/A0A803VZV2|||http://purl.uniprot.org/uniprot/U3JJX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S8 family.|||Involved in the processing of hormone and other protein precursors at sites comprised of pairs of basic amino acid residues. Substrates include POMC, renin, enkephalin, dynorphin, somatostatin, insulin and AGRP.|||Vesicle|||secretory vesicle http://togogenome.org/gene/59894:PRPF4 ^@ http://purl.uniprot.org/uniprot/A0A803VX82 ^@ Subcellular Location Annotation ^@ Nucleus speckle http://togogenome.org/gene/59894:TNFRSF6B ^@ http://purl.uniprot.org/uniprot/U3JTN8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:FOXN3 ^@ http://purl.uniprot.org/uniprot/A0A803W7A1|||http://purl.uniprot.org/uniprot/U3KCX1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TRAPPC2 ^@ http://purl.uniprot.org/uniprot/U3JPD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPP small subunits family. Sedlin subfamily.|||perinuclear region http://togogenome.org/gene/59894:SCUBE3 ^@ http://purl.uniprot.org/uniprot/A0A803V5Z8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:PPIP5K1 ^@ http://purl.uniprot.org/uniprot/A0A803VE09|||http://purl.uniprot.org/uniprot/A0A803VH72|||http://purl.uniprot.org/uniprot/A0A803WFJ1|||http://purl.uniprot.org/uniprot/U3KA05 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histidine acid phosphatase family. VIP1 subfamily.|||Bifunctional inositol kinase that acts in concert with the IP6K kinases to synthesize the diphosphate group-containing inositol pyrophosphates diphosphoinositol pentakisphosphate, PP-InsP5, and bis-diphosphoinositol tetrakisphosphate, (PP)2-InsP4. PP-InsP5 and (PP)2-InsP4, also respectively called InsP7 and InsP8, may regulate a variety of cellular processes, including apoptosis, vesicle trafficking, cytoskeletal dynamics, and exocytosis. Phosphorylates inositol hexakisphosphate (InsP6).|||cytosol http://togogenome.org/gene/59894:YY1 ^@ http://purl.uniprot.org/uniprot/U3JJ42 ^@ Similarity ^@ Belongs to the YY transcription factor family. http://togogenome.org/gene/59894:LOC101819009 ^@ http://purl.uniprot.org/uniprot/U3JJI2 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59894:TMEM230 ^@ http://purl.uniprot.org/uniprot/A0A803VPX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM134/TMEM230 family.|||Early endosome|||Endosome|||Involved in trafficking and recycling of synaptic vesicles.|||Late endosome|||Membrane|||Recycling endosome|||Vesicle|||autophagosome|||synaptic vesicle|||trans-Golgi network http://togogenome.org/gene/59894:RPL3 ^@ http://purl.uniprot.org/uniprot/U3KD18 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/59894:SGSM2 ^@ http://purl.uniprot.org/uniprot/U3JQ99 ^@ Similarity ^@ Belongs to the RUTBC family. http://togogenome.org/gene/59894:PIPOX ^@ http://purl.uniprot.org/uniprot/A0A803V9J0 ^@ Similarity ^@ Belongs to the MSOX/MTOX family. http://togogenome.org/gene/59894:P4HB ^@ http://purl.uniprot.org/uniprot/U3KBV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:FZD9 ^@ http://purl.uniprot.org/uniprot/U3KIN2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor Fz/Smo family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:SIRT5 ^@ http://purl.uniprot.org/uniprot/U3KGB5 ^@ Cofactor|||Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class III subfamily.|||Binds 1 zinc ion per subunit.|||In contrast to class I sirtuins, class III sirtuins have only weak deacetylase activity. Difference in substrate specificity is probably due to a larger hydrophobic pocket with 2 residues (Tyr-102 and Arg-105) that bind to malonylated and succinylated substrates and define the specificity.|||Mitochondrion|||NAD-dependent lysine demalonylase, desuccinylase and deglutarylase that specifically removes malonyl, succinyl and glutaryl groups on target proteins. Has weak NAD-dependent protein deacetylase activity; however this activity may not be physiologically relevant in vivo.|||Nucleus|||cytosol http://togogenome.org/gene/59894:MCM3 ^@ http://purl.uniprot.org/uniprot/U3JHC8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as component of the MCM2-7 complex (MCM complex) which is the replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differentially to the complex helicase activity.|||Belongs to the MCM family.|||Chromosome|||Component of the MCM2-7 complex.|||Nucleus http://togogenome.org/gene/59894:VIMP ^@ http://purl.uniprot.org/uniprot/U3K6J1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the selenoprotein S family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:CNKSR2 ^@ http://purl.uniprot.org/uniprot/A0A803VLR8 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/59894:RPL13 ^@ http://purl.uniprot.org/uniprot/U3JKK9 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL13 family. http://togogenome.org/gene/59894:HOGA1 ^@ http://purl.uniprot.org/uniprot/A0A803WEU9 ^@ Function|||Similarity|||Subunit ^@ Belongs to the DapA family.|||Catalyzes the final step in the metabolic pathway of hydroxyproline.|||Homotetramer. http://togogenome.org/gene/59894:CAPRIN1 ^@ http://purl.uniprot.org/uniprot/A0A803VDD0|||http://purl.uniprot.org/uniprot/A0A803VII7|||http://purl.uniprot.org/uniprot/A0A803WBX2|||http://purl.uniprot.org/uniprot/U3JF05 ^@ Similarity ^@ Belongs to the caprin family. http://togogenome.org/gene/59894:CENPV ^@ http://purl.uniprot.org/uniprot/U3JU62 ^@ Similarity ^@ Belongs to the Gfa family. http://togogenome.org/gene/59894:ATOH7 ^@ http://purl.uniprot.org/uniprot/U3KI44 ^@ Subcellular Location Annotation ^@ Nucleus|||Perikaryon|||axon http://togogenome.org/gene/59894:CCNE1 ^@ http://purl.uniprot.org/uniprot/U3JBS4 ^@ Similarity ^@ Belongs to the cyclin family. Cyclin E subfamily. http://togogenome.org/gene/59894:PIAS2 ^@ http://purl.uniprot.org/uniprot/U3K2Q7|||http://purl.uniprot.org/uniprot/U3K2R0 ^@ Similarity ^@ Belongs to the PIAS family. http://togogenome.org/gene/59894:TMEM27 ^@ http://purl.uniprot.org/uniprot/A0A803VSN1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101819471 ^@ http://purl.uniprot.org/uniprot/A0A803W310 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101816410 ^@ http://purl.uniprot.org/uniprot/U3K2V7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL22 family. http://togogenome.org/gene/59894:KLC4 ^@ http://purl.uniprot.org/uniprot/A0A803V3Y0|||http://purl.uniprot.org/uniprot/U3JDL9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/59894:MFSD9 ^@ http://purl.uniprot.org/uniprot/A0A803V8D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/59894:PDE6H ^@ http://purl.uniprot.org/uniprot/U3K9U0 ^@ Function|||Similarity ^@ Belongs to the rod/cone cGMP-PDE gamma subunit family.|||Participates in processes of transmission and amplification of the visual signal. cGMP-PDEs are the effector molecules in G-protein-mediated phototransduction in vertebrate rods and cones. http://togogenome.org/gene/59894:GPRC6A ^@ http://purl.uniprot.org/uniprot/A0A803VYU0|||http://purl.uniprot.org/uniprot/U3K926 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:TMEM258 ^@ http://purl.uniprot.org/uniprot/U3KBA4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OST5 family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59894:HOXA7 ^@ http://purl.uniprot.org/uniprot/A0A803WEB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59894:ATP6V1E1 ^@ http://purl.uniprot.org/uniprot/A0A803V0H7|||http://purl.uniprot.org/uniprot/U3K4W7 ^@ Similarity ^@ Belongs to the V-ATPase E subunit family. http://togogenome.org/gene/59894:TBL3 ^@ http://purl.uniprot.org/uniprot/U3JLC3 ^@ Subcellular Location Annotation ^@ nucleolus http://togogenome.org/gene/59894:CHRNG ^@ http://purl.uniprot.org/uniprot/U3JZ73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:GIMD1 ^@ http://purl.uniprot.org/uniprot/U3KCY5 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. AIG1/Toc34/Toc159-like paraseptin GTPase family. IAN subfamily. http://togogenome.org/gene/59894:MSL3 ^@ http://purl.uniprot.org/uniprot/U3JPG6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PLA2R1 ^@ http://purl.uniprot.org/uniprot/U3JP70 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101811767 ^@ http://purl.uniprot.org/uniprot/U3K8R4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c oxidase VIIb family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:ANAPC15 ^@ http://purl.uniprot.org/uniprot/U3JUV0 ^@ Similarity ^@ Belongs to the APC15 family. http://togogenome.org/gene/59894:LOC101818177 ^@ http://purl.uniprot.org/uniprot/A0A803VKB9 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59894:TP53I11 ^@ http://purl.uniprot.org/uniprot/U3KCR4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:GDAP1L1 ^@ http://purl.uniprot.org/uniprot/U3JRM9 ^@ Similarity ^@ Belongs to the GST superfamily. http://togogenome.org/gene/59894:CHD4 ^@ http://purl.uniprot.org/uniprot/U3JQC8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/59894:C8B ^@ http://purl.uniprot.org/uniprot/U3KCU0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Constituent of the membrane attack complex (MAC) that plays a key role in the innate and adaptive immune response by forming pores in the plasma membrane of target cells.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:WEE1 ^@ http://purl.uniprot.org/uniprot/U3JE23 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Ser/Thr protein kinase family. WEE1 subfamily.|||Binds 2 magnesium ions per subunit.|||Nucleus http://togogenome.org/gene/59894:LOC101810933 ^@ http://purl.uniprot.org/uniprot/U3JFV9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CHRND ^@ http://purl.uniprot.org/uniprot/U3JZ71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:TERF2IP ^@ http://purl.uniprot.org/uniprot/U3JIS2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with terf2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with terf2 or other factors, and regulates gene expression.|||Belongs to the RAP1 family.|||Homodimer.|||Nucleus|||telomere http://togogenome.org/gene/59894:ARL1 ^@ http://purl.uniprot.org/uniprot/U3K9E2 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59894:NEK3 ^@ http://purl.uniprot.org/uniprot/U3K1L2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:PPP2R5C ^@ http://purl.uniprot.org/uniprot/U3JJ70 ^@ Similarity ^@ Belongs to the phosphatase 2A regulatory subunit B56 family. http://togogenome.org/gene/59894:NCDN ^@ http://purl.uniprot.org/uniprot/U3JDB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the neurochondrin family.|||Postsynapse http://togogenome.org/gene/59894:AGPAT4 ^@ http://purl.uniprot.org/uniprot/U3KCF1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:ATP2B1 ^@ http://purl.uniprot.org/uniprot/A0A803W301|||http://purl.uniprot.org/uniprot/U3K7U3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIB subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:IRF6 ^@ http://purl.uniprot.org/uniprot/U3JCL5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:NUP155 ^@ http://purl.uniprot.org/uniprot/A0A803VEN7|||http://purl.uniprot.org/uniprot/U3JH77 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the non-repetitive/WGA-negative nucleoporin family.|||nuclear pore complex http://togogenome.org/gene/59894:AKT1 ^@ http://purl.uniprot.org/uniprot/U3JJZ0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. RAC subfamily. http://togogenome.org/gene/59894:NELL2 ^@ http://purl.uniprot.org/uniprot/A0A803VT73|||http://purl.uniprot.org/uniprot/U3K6G6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:HTR6 ^@ http://purl.uniprot.org/uniprot/U3K7P3 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:RC3H1 ^@ http://purl.uniprot.org/uniprot/U3JJY9 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/59894:EDEM2 ^@ http://purl.uniprot.org/uniprot/U3JTI8 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 47 family. http://togogenome.org/gene/59894:SLC25A14 ^@ http://purl.uniprot.org/uniprot/A0A803WER9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:SATB1 ^@ http://purl.uniprot.org/uniprot/A0A803WAT4|||http://purl.uniprot.org/uniprot/U3K3Q2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CUT homeobox family.|||Nucleus http://togogenome.org/gene/59894:P3H3 ^@ http://purl.uniprot.org/uniprot/U3JQ34 ^@ Similarity ^@ Belongs to the leprecan family. http://togogenome.org/gene/59894:ACKR3 ^@ http://purl.uniprot.org/uniprot/U3KL67 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:ARL6IP4 ^@ http://purl.uniprot.org/uniprot/U3K3P1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ARL6IP4 family.|||Nucleus speckle|||nucleolus http://togogenome.org/gene/59894:DDC ^@ http://purl.uniprot.org/uniprot/U3JYJ5 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:NSUN6 ^@ http://purl.uniprot.org/uniprot/U3JY68 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. RsmB/NOP family. http://togogenome.org/gene/59894:AKR1D1 ^@ http://purl.uniprot.org/uniprot/U3JM21 ^@ Similarity ^@ Belongs to the aldo/keto reductase family. http://togogenome.org/gene/59894:EI24 ^@ http://purl.uniprot.org/uniprot/U3JR93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EI24 family.|||Membrane http://togogenome.org/gene/59894:MRPL19 ^@ http://purl.uniprot.org/uniprot/U3JFX7 ^@ Similarity ^@ Belongs to the bacterial ribosomal protein bL19 family. http://togogenome.org/gene/59894:ATP8A2 ^@ http://purl.uniprot.org/uniprot/U3K1Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59894:HAO1 ^@ http://purl.uniprot.org/uniprot/U3K8Q1 ^@ Similarity ^@ Belongs to the FMN-dependent alpha-hydroxy acid dehydrogenase family. http://togogenome.org/gene/59894:GTF2H5 ^@ http://purl.uniprot.org/uniprot/U3KDP1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TFB5 family.|||Component of the 7-subunit TFIIH core complex.|||In NER, TFIIH acts by opening DNA around the lesion to allow the excision of the damaged oligonucleotide and its replacement by a new DNA fragment. In transcription, TFIIH has an essential role in transcription initiation. When the pre-initiation complex (PIC) has been established, TFIIH is required for promoter opening and promoter escape.|||Nucleus http://togogenome.org/gene/59894:TRIM32 ^@ http://purl.uniprot.org/uniprot/U3KJC2 ^@ Similarity ^@ Belongs to the TRIM/RBCC family. http://togogenome.org/gene/59894:FAM172A ^@ http://purl.uniprot.org/uniprot/U3K357 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM172 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:MPP3 ^@ http://purl.uniprot.org/uniprot/U3JDK7 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/59894:OPRM1 ^@ http://purl.uniprot.org/uniprot/U3KD51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Perikaryon|||axon|||dendrite http://togogenome.org/gene/59894:LOC101817098 ^@ http://purl.uniprot.org/uniprot/A0A803VH40 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:OXR1 ^@ http://purl.uniprot.org/uniprot/A0A803VTU1|||http://purl.uniprot.org/uniprot/A0A803VU84|||http://purl.uniprot.org/uniprot/U3JU84 ^@ Similarity ^@ Belongs to the OXR1 family. http://togogenome.org/gene/59894:LAMP2 ^@ http://purl.uniprot.org/uniprot/A0A803WD13|||http://purl.uniprot.org/uniprot/U3JFP7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/59894:MEOX2 ^@ http://purl.uniprot.org/uniprot/U3K5U7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:EXOC6 ^@ http://purl.uniprot.org/uniprot/U3JZP9 ^@ Function|||Similarity ^@ Belongs to the SEC15 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/59894:DAG1 ^@ http://purl.uniprot.org/uniprot/U3K2Z0 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The dystroglycan complex is involved in a number of processes including laminin and basement membrane assembly, sarcolemmal stability, cell survival, peripheral nerve myelination, nodal structure, cell migration, and epithelial polarization.|||Transmembrane protein that plays important roles in connecting the extracellular matrix to the cytoskeleton. Acts as a cell adhesion receptor in both muscle and non-muscle tissues. Receptor for both DMD and UTRN and, through these interactions, scaffolds axin to the cytoskeleton. Also functions in cell adhesion-mediated signaling and implicated in cell polarity.|||extracellular space|||nucleoplasm|||sarcolemma http://togogenome.org/gene/59894:EVX1 ^@ http://purl.uniprot.org/uniprot/U3K435 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PTGS1 ^@ http://purl.uniprot.org/uniprot/U3JH32 ^@ Caution|||Cofactor|||Similarity|||Subunit ^@ Belongs to the prostaglandin G/H synthase family.|||Binds 1 heme b (iron(II)-protoporphyrin IX) group per subunit.|||Homodimer.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:KCNS3 ^@ http://purl.uniprot.org/uniprot/U3KKJ0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:STARD8 ^@ http://purl.uniprot.org/uniprot/A0A803V5F2|||http://purl.uniprot.org/uniprot/U3JNM6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:KPNA1 ^@ http://purl.uniprot.org/uniprot/U3JQT0|||http://purl.uniprot.org/uniprot/U3JQT2 ^@ Similarity ^@ Belongs to the importin alpha family. http://togogenome.org/gene/59894:PROM1 ^@ http://purl.uniprot.org/uniprot/A0A803VYJ2|||http://purl.uniprot.org/uniprot/U3K3R9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/59894:LOC101818392 ^@ http://purl.uniprot.org/uniprot/U3JNC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family. BCS1 subfamily.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:RAD50 ^@ http://purl.uniprot.org/uniprot/U3KG88 ^@ Similarity ^@ Belongs to the SMC family. RAD50 subfamily. http://togogenome.org/gene/59894:TBX5 ^@ http://purl.uniprot.org/uniprot/U3JZB8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:CMTM8 ^@ http://purl.uniprot.org/uniprot/U3K3D2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CLNS1A ^@ http://purl.uniprot.org/uniprot/A0A803VPV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the pICln (TC 1.A.47) family.|||Nucleus http://togogenome.org/gene/59894:MYO7B ^@ http://purl.uniprot.org/uniprot/U3KGL7 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:PLTP ^@ http://purl.uniprot.org/uniprot/U3JPU4 ^@ Similarity ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family. http://togogenome.org/gene/59894:SEPT11 ^@ http://purl.uniprot.org/uniprot/U3K1F7 ^@ Similarity ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family. http://togogenome.org/gene/59894:LCN15 ^@ http://purl.uniprot.org/uniprot/U3JQV2 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/59894:KCNMA1 ^@ http://purl.uniprot.org/uniprot/A0A803VID4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. Calcium-activated (TC 1.A.1.3) subfamily. KCa1.1/KCNMA1 sub-subfamily.|||Membrane http://togogenome.org/gene/59894:STAM2 ^@ http://purl.uniprot.org/uniprot/A0A803W9G3|||http://purl.uniprot.org/uniprot/U3KHM1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the STAM family.|||Early endosome membrane http://togogenome.org/gene/59894:ORC3 ^@ http://purl.uniprot.org/uniprot/U3JJV8 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ORC3 family.|||Component of ORC, a complex composed of at least 6 subunits: ORC1, ORC2, ORC3, ORC4, ORC5 and ORC6. ORC is regulated in a cell-cycle dependent manner. It is sequentially assembled at the exit from anaphase of mitosis and disassembled as cells enter S phase.|||Nucleus http://togogenome.org/gene/59894:SEMA6D ^@ http://purl.uniprot.org/uniprot/A0A803VUY7|||http://purl.uniprot.org/uniprot/A0A803W1Q6|||http://purl.uniprot.org/uniprot/U3KAX0 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CSRNP1 ^@ http://purl.uniprot.org/uniprot/U3JW12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AXUD1 family.|||Nucleus http://togogenome.org/gene/59894:PITPNM1 ^@ http://purl.uniprot.org/uniprot/U3JF35 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/59894:LOC101813071 ^@ http://purl.uniprot.org/uniprot/U3JL74 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nuclear hormone receptor that can act as a repressor or activator of transcription. High affinity receptor for thyroid hormones, including triiodothyronine and thyroxine.|||Nucleus http://togogenome.org/gene/59894:TFEB ^@ http://purl.uniprot.org/uniprot/U3JKB4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MiT/TFE family.|||Nucleus http://togogenome.org/gene/59894:LOC101808513 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:BRF1 ^@ http://purl.uniprot.org/uniprot/A0A803V409|||http://purl.uniprot.org/uniprot/U3JKC9 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/59894:LOC101818934 ^@ http://purl.uniprot.org/uniprot/U3KI75 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:SLC25A32 ^@ http://purl.uniprot.org/uniprot/U3JTX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:LOC101820195 ^@ http://purl.uniprot.org/uniprot/U3JFJ3 ^@ Similarity ^@ Belongs to the CD200R family. http://togogenome.org/gene/59894:COPS4 ^@ http://purl.uniprot.org/uniprot/U3JSV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN4 family.|||Nucleus|||Vesicle|||synaptic vesicle http://togogenome.org/gene/59894:OSBPL6 ^@ http://purl.uniprot.org/uniprot/U3JL89 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:PARVG ^@ http://purl.uniprot.org/uniprot/U3JVU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||cytoskeleton http://togogenome.org/gene/59894:RAB3C ^@ http://purl.uniprot.org/uniprot/U3K8X0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Cell membrane|||Protein transport. Probably involved in vesicular traffic. http://togogenome.org/gene/59894:TSSK2 ^@ http://purl.uniprot.org/uniprot/U3KLD8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:CACNA2D2 ^@ http://purl.uniprot.org/uniprot/U3K2Y2 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/59894:LOC101807812 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:SYNJ2 ^@ http://purl.uniprot.org/uniprot/U3KDN4 ^@ Similarity ^@ Belongs to the synaptojanin family.|||In the central section; belongs to the inositol 1,4,5-trisphosphate 5-phosphatase family. http://togogenome.org/gene/59894:KIF24 ^@ http://purl.uniprot.org/uniprot/A0A803W994|||http://purl.uniprot.org/uniprot/U3K5K1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:ME1 ^@ http://purl.uniprot.org/uniprot/U3JJ88|||http://purl.uniprot.org/uniprot/U3JJ92 ^@ Cofactor|||Similarity ^@ Belongs to the malic enzymes family.|||Divalent metal cations. Prefers magnesium or manganese. http://togogenome.org/gene/59894:BTK ^@ http://purl.uniprot.org/uniprot/U3KA25 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:COQ4 ^@ http://purl.uniprot.org/uniprot/U3JF63 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ4 family.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9.|||Component of the coenzyme Q biosynthetic pathway. May play a role in organizing a multi-subunit COQ enzyme complex required for coenzyme Q biosynthesis. Required for steady-state levels of other COQ polypeptides.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SLITRK6 ^@ http://purl.uniprot.org/uniprot/U3KJU5 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/59894:PIK3CG ^@ http://purl.uniprot.org/uniprot/U3K6Q5 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/59894:LOC101819765 ^@ http://purl.uniprot.org/uniprot/A0A803W5W6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:PPCS ^@ http://purl.uniprot.org/uniprot/A0A803VBN1 ^@ Similarity ^@ Belongs to the PPC synthetase family. http://togogenome.org/gene/59894:SCMH1 ^@ http://purl.uniprot.org/uniprot/U3JEH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCM family.|||Nucleus http://togogenome.org/gene/59894:ZDHHC3 ^@ http://purl.uniprot.org/uniprot/A0A803WAJ2|||http://purl.uniprot.org/uniprot/U3JIV1 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:PLIN2 ^@ http://purl.uniprot.org/uniprot/U3JK86 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/59894:SNRPD1 ^@ http://purl.uniprot.org/uniprot/U3JJ00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||Plays a role in pre-mRNA splicing as a core component of the spliceosomal U1, U2, U4 and U5 small nuclear ribonucleoproteins (snRNPs), the building blocks of the spliceosome. http://togogenome.org/gene/59894:HABP2 ^@ http://purl.uniprot.org/uniprot/U3JHU1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:PREPL ^@ http://purl.uniprot.org/uniprot/U3KEW7 ^@ Similarity ^@ Belongs to the peptidase S9A family. http://togogenome.org/gene/59894:RPL23A ^@ http://purl.uniprot.org/uniprot/U3JV50 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL23 family. http://togogenome.org/gene/59894:TAX1BP3 ^@ http://purl.uniprot.org/uniprot/U3JU11 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||May regulate a number of protein-protein interactions by competing for PDZ domain binding sites.|||Nucleus http://togogenome.org/gene/59894:TIMP3 ^@ http://purl.uniprot.org/uniprot/A0A803W427 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I35 (TIMP) family.|||extracellular matrix http://togogenome.org/gene/59894:TRMT11 ^@ http://purl.uniprot.org/uniprot/A0A803W725 ^@ Function ^@ Catalytic subunit of an S-adenosyl-L-methionine-dependent tRNA methyltransferase complex that mediates the methylation of the guanosine nucleotide at position 10 (m2G10) in tRNAs. http://togogenome.org/gene/59894:PGM2 ^@ http://purl.uniprot.org/uniprot/U3K3X8 ^@ Similarity ^@ Belongs to the phosphohexose mutase family. http://togogenome.org/gene/59894:ANO9 ^@ http://purl.uniprot.org/uniprot/U3KAL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Membrane http://togogenome.org/gene/59894:LOC101814802 ^@ http://purl.uniprot.org/uniprot/U3KC12 ^@ Similarity ^@ Belongs to the peptidase A1 family. http://togogenome.org/gene/59894:TF ^@ http://purl.uniprot.org/uniprot/U3JK93 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/59894:LOC101809755 ^@ http://purl.uniprot.org/uniprot/U3JW78 ^@ Similarity|||Subunit ^@ Belongs to the lyase 1 family. Argininosuccinate lyase subfamily.|||Homotetramer. http://togogenome.org/gene/59894:LOC101815333 ^@ http://purl.uniprot.org/uniprot/A0A803VIC5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cytoplasm|||Membrane|||Nucleus|||axon http://togogenome.org/gene/59894:LOC101817656 ^@ http://purl.uniprot.org/uniprot/U3KJL2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:PRKCH ^@ http://purl.uniprot.org/uniprot/U3JLA6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/59894:SHROOM1 ^@ http://purl.uniprot.org/uniprot/A0A803VI29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shroom family.|||cytoskeleton http://togogenome.org/gene/59894:LOC101810536 ^@ http://purl.uniprot.org/uniprot/U3KFU2 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/59894:LIMK2 ^@ http://purl.uniprot.org/uniprot/U3JYE6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. http://togogenome.org/gene/59894:ADRA1A ^@ http://purl.uniprot.org/uniprot/U3K9X1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||Nucleus membrane|||caveola http://togogenome.org/gene/59894:UBE2C ^@ http://purl.uniprot.org/uniprot/A0A803V7M3 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:CCDC58 ^@ http://purl.uniprot.org/uniprot/U3JQV0 ^@ Similarity ^@ Belongs to the MIX23 family. http://togogenome.org/gene/59894:MCM9 ^@ http://purl.uniprot.org/uniprot/A0A803WEE0|||http://purl.uniprot.org/uniprot/U3K9H2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM family.|||Nucleus http://togogenome.org/gene/59894:ILDR1 ^@ http://purl.uniprot.org/uniprot/U3JTU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. LISCH7 family.|||Membrane|||tight junction http://togogenome.org/gene/59894:FLVCR1 ^@ http://purl.uniprot.org/uniprot/U3KD17 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:COPB1 ^@ http://purl.uniprot.org/uniprot/U3JDR1 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59894:ARFGEF2 ^@ http://purl.uniprot.org/uniprot/U3KEN4 ^@ Subcellular Location Annotation ^@ Golgi apparatus|||perinuclear region http://togogenome.org/gene/59894:EPHB3 ^@ http://purl.uniprot.org/uniprot/U3K0H2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ITGA4 ^@ http://purl.uniprot.org/uniprot/U3JLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin alpha chain family.|||Membrane http://togogenome.org/gene/59894:TGFBR1 ^@ http://purl.uniprot.org/uniprot/A0A803VUR9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:RAD21L1 ^@ http://purl.uniprot.org/uniprot/U3JTA9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/59894:TSPO2 ^@ http://purl.uniprot.org/uniprot/U3JMR7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TspO/BZRP family.|||Membrane http://togogenome.org/gene/59894:LOC101812006 ^@ http://purl.uniprot.org/uniprot/U3KL33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM15 family.|||Membrane http://togogenome.org/gene/59894:NINJ2 ^@ http://purl.uniprot.org/uniprot/U3JMT2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ninjurin family.|||Membrane http://togogenome.org/gene/59894:NCAPH ^@ http://purl.uniprot.org/uniprot/U3JC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CND2 (condensin subunit 2) family.|||Chromosome|||Cytoplasm http://togogenome.org/gene/59894:LOC101806037 ^@ http://purl.uniprot.org/uniprot/A0A803WEJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome b5 family.|||Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||Endoplasmic reticulum http://togogenome.org/gene/59894:SLC25A40 ^@ http://purl.uniprot.org/uniprot/A0A803VMV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:LOC101811258 ^@ http://purl.uniprot.org/uniprot/U3JWV6 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/59894:TMEM106B ^@ http://purl.uniprot.org/uniprot/A0A803V357 ^@ Similarity ^@ Belongs to the TMEM106 family. http://togogenome.org/gene/59894:LOC101810101 ^@ http://purl.uniprot.org/uniprot/A0A803V395|||http://purl.uniprot.org/uniprot/U3KBK9 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:ATP6V1A ^@ http://purl.uniprot.org/uniprot/U3JRC0 ^@ Similarity ^@ Belongs to the ATPase alpha/beta chains family. http://togogenome.org/gene/59894:PIH1D3 ^@ http://purl.uniprot.org/uniprot/U3K9P7 ^@ Similarity ^@ Belongs to the PIH1 family. http://togogenome.org/gene/59894:OPTN ^@ http://purl.uniprot.org/uniprot/U3JGS6 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Endosome|||Golgi apparatus|||May act by regulating membrane trafficking and cellular morphogenesis.|||Recycling endosome|||Vesicle|||autophagosome|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/59894:NFIC ^@ http://purl.uniprot.org/uniprot/U3KAK1|||http://purl.uniprot.org/uniprot/U3KAK4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CTF/NF-I family.|||Binds DNA as a homodimer.|||Nucleus|||Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. http://togogenome.org/gene/59894:EOGT ^@ http://purl.uniprot.org/uniprot/A0A803VCD2 ^@ Similarity ^@ Belongs to the glycosyltransferase 61 family. http://togogenome.org/gene/59894:CAP2 ^@ http://purl.uniprot.org/uniprot/U3KG26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAP family.|||Cell membrane http://togogenome.org/gene/59894:LOC101810612 ^@ http://purl.uniprot.org/uniprot/A0A803WGH3 ^@ Function|||Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily.|||Dual specificity phosphatase able to dephosphorylate phosphotyrosine, phosphoserine and phosphothreonine residues, with a preference for phosphotyrosine as a substrate. http://togogenome.org/gene/59894:CUL1 ^@ http://purl.uniprot.org/uniprot/U3K6V8 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59894:LOC101819449 ^@ http://purl.uniprot.org/uniprot/U3KB99 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:IPO8 ^@ http://purl.uniprot.org/uniprot/A0A803W2L6 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ATP6V1D ^@ http://purl.uniprot.org/uniprot/U3JRT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the V-ATPase D subunit family.|||clathrin-coated vesicle membrane http://togogenome.org/gene/59894:SLC2A1 ^@ http://purl.uniprot.org/uniprot/U3JMJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family.|||Membrane|||Photoreceptor inner segment http://togogenome.org/gene/59894:L3MBTL3 ^@ http://purl.uniprot.org/uniprot/A0A803VY53|||http://purl.uniprot.org/uniprot/U3KAS1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:IPO13 ^@ http://purl.uniprot.org/uniprot/U3JS59 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the importin beta family.|||Cytoplasm|||Interacts with UBC9, RAN, RBM8A, eIF-1A and PAX6.|||Nucleus http://togogenome.org/gene/59894:CLCN3 ^@ http://purl.uniprot.org/uniprot/A0A803VFZ9|||http://purl.uniprot.org/uniprot/A0A803VPK3|||http://purl.uniprot.org/uniprot/U3KA51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family. ClC-3/CLCN3 subfamily.|||Cell membrane|||Early endosome membrane|||Endosome membrane|||Late endosome membrane|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:PDE8B ^@ http://purl.uniprot.org/uniprot/U3K5Y8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE8 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:USP49 ^@ http://purl.uniprot.org/uniprot/U3JJW3 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:NUDT21 ^@ http://purl.uniprot.org/uniprot/U3JYQ2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Nudix hydrolase family. CPSF5 subfamily.|||Component of the cleavage factor Im (CFIm) complex that functions as an activator of the pre-mRNA 3'-end cleavage and polyadenylation processing required for the maturation of pre-mRNA into functional mRNAs. CFIm contributes to the recruitment of multiprotein complexes on specific sequences on the pre-mRNA 3'-end, so called cleavage and polyadenylation signals (pA signals). Most pre-mRNAs contain multiple pA signals, resulting in alternative cleavage and polyadenylation (APA) producing mRNAs with variable 3'-end formation. The CFIm complex acts as a key regulator of cleavage and polyadenylation site choice during APA through its binding to 5'-UGUA-3' elements localized in the 3'-untranslated region (UTR) for a huge number of pre-mRNAs.|||Cytoplasm|||Homodimer (via N- and C-terminus); binds RNA as homodimer. Component of the cleavage factor Im (CFIm) complex.|||Nucleus http://togogenome.org/gene/59894:HSD3B7 ^@ http://purl.uniprot.org/uniprot/U3K419 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59894:LOC101818814 ^@ http://purl.uniprot.org/uniprot/U3KHJ4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat Groucho/TLE family.|||Nucleus http://togogenome.org/gene/59894:PDCD10 ^@ http://purl.uniprot.org/uniprot/A0A803VNP5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PDCD10 family.|||Cell membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:RPS2 ^@ http://purl.uniprot.org/uniprot/U3JL79 ^@ Function|||Similarity ^@ Belongs to the universal ribosomal protein uS5 family.|||Component of the ribosome, a large ribonucleoprotein complex responsible for the synthesis of proteins in the cell. The small ribosomal subunit (SSU) binds messenger RNAs (mRNAs) and translates the encoded message by selecting cognate aminoacyl-transfer RNA (tRNA) molecules. The large subunit (LSU) contains the ribosomal catalytic site termed the peptidyl transferase center (PTC), which catalyzes the formation of peptide bonds, thereby polymerizing the amino acids delivered by tRNAs into a polypeptide chain. The nascent polypeptides leave the ribosome through a tunnel in the LSU and interact with protein factors that function in enzymatic processing, targeting, and the membrane insertion of nascent chains at the exit of the ribosomal tunnel. Plays a role in the assembly and function of the 40S ribosomal subunit. Mutations in this protein affects the control of translational fidelity. Involved in nucleolar processing of pre-18S ribosomal RNA and ribosome assembly. http://togogenome.org/gene/59894:DYNLL2 ^@ http://purl.uniprot.org/uniprot/U3JYN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light chain family.|||cytoskeleton http://togogenome.org/gene/59894:VGLL4 ^@ http://purl.uniprot.org/uniprot/A0A803WAQ9|||http://purl.uniprot.org/uniprot/U3JB54 ^@ Function|||Similarity ^@ Belongs to the vestigial family.|||May act as a specific coactivator for the mammalian TEFs. http://togogenome.org/gene/59894:BTG4 ^@ http://purl.uniprot.org/uniprot/U3JUD8 ^@ Similarity ^@ Belongs to the BTG family. http://togogenome.org/gene/59894:POP4 ^@ http://purl.uniprot.org/uniprot/U3JBQ8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the eukaryotic/archaeal RNase P protein component 1 family.|||Component of nuclear RNase P and RNase MRP.|||Component of ribonuclease P, a ribonucleoprotein complex that generates mature tRNA molecules by cleaving their 5'-ends.|||nucleolus http://togogenome.org/gene/59894:C4AHXorf56 ^@ http://purl.uniprot.org/uniprot/U3JFW0 ^@ Similarity ^@ Belongs to the STEEP1 family. http://togogenome.org/gene/59894:P2RX3 ^@ http://purl.uniprot.org/uniprot/U3K9X5 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the P2X receptor family.|||Functional P2XRs are organized as homomeric and heteromeric trimers.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Receptor for ATP that acts as a ligand-gated ion channel. http://togogenome.org/gene/59894:RIMKLB ^@ http://purl.uniprot.org/uniprot/U3JXT2 ^@ Similarity ^@ Belongs to the RimK family. http://togogenome.org/gene/59894:TMEM33 ^@ http://purl.uniprot.org/uniprot/A0A803VC78 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PER33/POM33 family.|||Membrane http://togogenome.org/gene/59894:DLGAP1 ^@ http://purl.uniprot.org/uniprot/A0A803W2Z5 ^@ Similarity ^@ Belongs to the SAPAP family. http://togogenome.org/gene/59894:RPL21 ^@ http://purl.uniprot.org/uniprot/A0A803VMB2 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL21 family. http://togogenome.org/gene/59894:SIAH1 ^@ http://purl.uniprot.org/uniprot/U3JBF4 ^@ Domain|||Function|||Similarity ^@ Belongs to the SINA (Seven in absentia) family.|||E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins. E3 ubiquitin ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfers the ubiquitin to targeted substrates.|||The RING-type zinc finger domain is essential for ubiquitin ligase activity.|||The SBD domain (substrate-binding domain) mediates the interaction with substrate proteins. It is related to the TRAF family. http://togogenome.org/gene/59894:FAM189B ^@ http://purl.uniprot.org/uniprot/U3JJR0 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/59894:CDH19 ^@ http://purl.uniprot.org/uniprot/U3JVU7 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:UBL3 ^@ http://purl.uniprot.org/uniprot/U3K1H4 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:NRCAM ^@ http://purl.uniprot.org/uniprot/U3K6T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/59894:RAB11FIP4 ^@ http://purl.uniprot.org/uniprot/U3JHW9 ^@ Subcellular Location Annotation ^@ Cleavage furrow|||Endosome membrane|||Membrane|||Midbody|||Recycling endosome membrane http://togogenome.org/gene/59894:POLR3B ^@ http://purl.uniprot.org/uniprot/U3KG47 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. http://togogenome.org/gene/59894:KCNE2 ^@ http://purl.uniprot.org/uniprot/U3KI99 ^@ Similarity ^@ Belongs to the potassium channel KCNE family. http://togogenome.org/gene/59894:LOC101810531 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:LOC101809663 ^@ http://purl.uniprot.org/uniprot/A0A803VDW7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:GPS1 ^@ http://purl.uniprot.org/uniprot/A0A803V1K8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CSN1 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:LOC101812227 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:PITPNM3 ^@ http://purl.uniprot.org/uniprot/U3JPZ7 ^@ Similarity ^@ Belongs to the PtdIns transfer protein family. PI transfer class IIA subfamily. http://togogenome.org/gene/59894:ZFYVE16 ^@ http://purl.uniprot.org/uniprot/U3KEF3 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Early endosome membrane http://togogenome.org/gene/59894:HS3ST1 ^@ http://purl.uniprot.org/uniprot/U3KJY7 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:GRIA2 ^@ http://purl.uniprot.org/uniprot/A0A803V671 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:PIK3R2 ^@ http://purl.uniprot.org/uniprot/U3KHD9 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/59894:PPIH ^@ http://purl.uniprot.org/uniprot/U3K6T2 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59894:P4HA1 ^@ http://purl.uniprot.org/uniprot/A0A803W1H8|||http://purl.uniprot.org/uniprot/U3KEA2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the P4HA family.|||Catalyzes the post-translational formation of 4-hydroxyproline in -Xaa-Pro-Gly- sequences in collagens and other proteins.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:TNFRSF11A ^@ http://purl.uniprot.org/uniprot/A0A803VHH4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CAPN15 ^@ http://purl.uniprot.org/uniprot/A0A803W1W6|||http://purl.uniprot.org/uniprot/U3JQ19 ^@ Similarity ^@ Belongs to the peptidase C2 family. http://togogenome.org/gene/59894:LOC101812793 ^@ http://purl.uniprot.org/uniprot/U3JH67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/59894:AMT ^@ http://purl.uniprot.org/uniprot/U3K304 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvT family.|||Mitochondrion|||The glycine cleavage system catalyzes the degradation of glycine.|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/59894:PDIA6 ^@ http://purl.uniprot.org/uniprot/A0A803VCQ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein disulfide isomerase family.|||Endoplasmic reticulum lumen|||Melanosome http://togogenome.org/gene/59894:NME8 ^@ http://purl.uniprot.org/uniprot/U3JJI5 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59894:GJA3 ^@ http://purl.uniprot.org/uniprot/U3KKC6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:ATP6V1C1 ^@ http://purl.uniprot.org/uniprot/U3JTR6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase C subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. Subunit C is necessary for the assembly of the catalytic sector of the enzyme and is likely to have a specific function in its catalytic activity.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. The V1 complex consists of three catalytic AB heterodimers that form a heterohexamer, three peripheral stalks each consisting of EG heterodimers, one central rotor including subunits D and F, and the regulatory subunits C and H. The proton translocation complex V0 consists of the proton transport subunit a, a ring of proteolipid subunits c9c'', rotary subunit d, subunits e and f, and two accessory subunits. http://togogenome.org/gene/59894:ETV6 ^@ http://purl.uniprot.org/uniprot/U3JIY0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:LOC101808185 ^@ http://purl.uniprot.org/uniprot/U3JFJ7 ^@ Similarity ^@ Belongs to the flavin monoamine oxidase family. http://togogenome.org/gene/59894:CACNA2D4 ^@ http://purl.uniprot.org/uniprot/U3JKY1 ^@ Similarity ^@ Belongs to the calcium channel subunit alpha-2/delta family. http://togogenome.org/gene/59894:NRG4 ^@ http://purl.uniprot.org/uniprot/U3K818 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuregulin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:KIF2A ^@ http://purl.uniprot.org/uniprot/U3K953 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:REV1 ^@ http://purl.uniprot.org/uniprot/U3JMS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-Y family.|||Deoxycytidyl transferase involved in DNA repair. Transfers a dCMP residue from dCTP to the 3'-end of a DNA primer in a template-dependent reaction. May assist in the first step in the bypass of abasic lesions by the insertion of a nucleotide opposite the lesion. Required for normal induction of mutations by physical and chemical agents.|||Nucleus http://togogenome.org/gene/59894:TMEM35 ^@ http://purl.uniprot.org/uniprot/U3KAB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DoxX family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane|||Vesicle http://togogenome.org/gene/59894:LOC101814878 ^@ http://purl.uniprot.org/uniprot/U3KFA9 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/59894:ORC4 ^@ http://purl.uniprot.org/uniprot/A0A803WFZ3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ORC4 family.|||Component of the origin recognition complex (ORC) that binds origins of replication.|||Nucleus http://togogenome.org/gene/59894:PUS7 ^@ http://purl.uniprot.org/uniprot/U3K6W2 ^@ Similarity ^@ Belongs to the pseudouridine synthase TruD family. http://togogenome.org/gene/59894:GTF2H1 ^@ http://purl.uniprot.org/uniprot/U3K9D1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TFB1 family.|||Nucleus http://togogenome.org/gene/59894:GNPAT ^@ http://purl.uniprot.org/uniprot/U3JKW1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GPAT/DAPAT family.|||Peroxisome membrane http://togogenome.org/gene/59894:NLGN1 ^@ http://purl.uniprot.org/uniprot/A0A803W6E1|||http://purl.uniprot.org/uniprot/U3K190 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type-B carboxylesterase/lipase family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:UBE4A ^@ http://purl.uniprot.org/uniprot/U3K5X3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ubiquitin conjugation factor E4 family.|||Cytoplasm http://togogenome.org/gene/59894:HMOX2 ^@ http://purl.uniprot.org/uniprot/U3JNT3 ^@ Similarity ^@ Belongs to the heme oxygenase family. http://togogenome.org/gene/59894:CD28 ^@ http://purl.uniprot.org/uniprot/U3JM69 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TMOD3 ^@ http://purl.uniprot.org/uniprot/A0A803W3Y5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:SHC1 ^@ http://purl.uniprot.org/uniprot/A0A803W6E8 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:T ^@ http://purl.uniprot.org/uniprot/U3KCL7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:CCDC85C ^@ http://purl.uniprot.org/uniprot/A0A803V4Z4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC85 family.|||adherens junction http://togogenome.org/gene/59894:KIAA0430 ^@ http://purl.uniprot.org/uniprot/U3KI18 ^@ Subcellular Location Annotation ^@ Peroxisome http://togogenome.org/gene/59894:DYNC2LI1 ^@ http://purl.uniprot.org/uniprot/A0A803VWW1|||http://purl.uniprot.org/uniprot/U3KE12 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dynein light intermediate chain family.|||centrosome|||cilium|||cilium axoneme|||cilium basal body http://togogenome.org/gene/59894:GNPDA1 ^@ http://purl.uniprot.org/uniprot/A0A803V6X6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glucosamine/galactosamine-6-phosphate isomerase family.|||Cytoplasm|||Homohexamer. http://togogenome.org/gene/59894:GPX8 ^@ http://purl.uniprot.org/uniprot/A0A803VB18 ^@ Similarity ^@ Belongs to the glutathione peroxidase family. http://togogenome.org/gene/59894:LOC101821448 ^@ http://purl.uniprot.org/uniprot/U3JSA8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. http://togogenome.org/gene/59894:MDK ^@ http://purl.uniprot.org/uniprot/U3JUR3 ^@ Similarity ^@ Belongs to the pleiotrophin family. http://togogenome.org/gene/59894:PROKR1 ^@ http://purl.uniprot.org/uniprot/A0A803VSW0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:PLD5 ^@ http://purl.uniprot.org/uniprot/U3KA26 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/59894:SH3BP5 ^@ http://purl.uniprot.org/uniprot/U3K382 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SH3BP5 family.|||Cytoplasm|||Functions as guanine nucleotide exchange factor (GEF) for RAB11A.|||Interacts with GDP-bound and nucleotide-free forms of RAB11A.|||The N-terminal half of the protein mediates interaction with RAB11A and functions as guanine nucleotide exchange factor. Four long alpha-helices (interrupted by a central kink) assemble into coiled coils, giving rise to a 'V' shape. http://togogenome.org/gene/59894:RAB9A ^@ http://purl.uniprot.org/uniprot/U3KL70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||phagosome membrane http://togogenome.org/gene/59894:MATK ^@ http://purl.uniprot.org/uniprot/A0A803V1L1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:LOC101808700 ^@ http://purl.uniprot.org/uniprot/U3JS51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COX17 family.|||Mitochondrion intermembrane space http://togogenome.org/gene/59894:FAM83F ^@ http://purl.uniprot.org/uniprot/U3KCJ5 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/59894:GPCPD1 ^@ http://purl.uniprot.org/uniprot/A0A803V0T6|||http://purl.uniprot.org/uniprot/A0A803VW46 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/59894:CRTAC1 ^@ http://purl.uniprot.org/uniprot/U3K102 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:C1H11orf73 ^@ http://purl.uniprot.org/uniprot/A0A803W075 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a specific nuclear import carrier for HSP70 proteins following heat-shock stress: acts by mediating the nucleoporin-dependent translocation of ATP-bound HSP70 proteins into the nucleus. HSP70 proteins import is required to protect cells from heat shock damages. Does not translocate ADP-bound HSP70 proteins into the nucleus.|||Belongs to the OPI10 family.|||Cytoplasm|||Forms an asymmetric homodimer; required for binding and nuclear import of HSP70 proteins. Interacts with ATP-bound HSP70 proteins.|||Nucleus|||cytosol http://togogenome.org/gene/59894:MTMR9 ^@ http://purl.uniprot.org/uniprot/U3JIU7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/59894:BCL9 ^@ http://purl.uniprot.org/uniprot/A0A803VU06 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BCL9 family.|||Nucleus http://togogenome.org/gene/59894:NKAIN4 ^@ http://purl.uniprot.org/uniprot/A0A803V457 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101820249 ^@ http://purl.uniprot.org/uniprot/A0A803W2W9|||http://purl.uniprot.org/uniprot/U3K820 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM76 family.|||Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/59894:GPR15 ^@ http://purl.uniprot.org/uniprot/U3KIE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:HMGB1 ^@ http://purl.uniprot.org/uniprot/U3K1G9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGB family.|||Chromosome|||Secreted http://togogenome.org/gene/59894:WNT5B ^@ http://purl.uniprot.org/uniprot/U3JN09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:SESN1 ^@ http://purl.uniprot.org/uniprot/U3KBC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sestrin family.|||Cytoplasm http://togogenome.org/gene/59894:SLCO1A2 ^@ http://purl.uniprot.org/uniprot/A0A803W175|||http://purl.uniprot.org/uniprot/U3K039 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101810322 ^@ http://purl.uniprot.org/uniprot/U3JBK4 ^@ Similarity ^@ Belongs to the hexokinase family. http://togogenome.org/gene/59894:FAHD1 ^@ http://purl.uniprot.org/uniprot/U3KJQ1 ^@ Similarity ^@ Belongs to the FAH family. http://togogenome.org/gene/59894:MPPED1 ^@ http://purl.uniprot.org/uniprot/A0A803VW19 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/59894:NUP62CL ^@ http://purl.uniprot.org/uniprot/U3K9P3 ^@ Similarity ^@ Belongs to the nucleoporin NSP1/NUP62 family. http://togogenome.org/gene/59894:LOC101812429 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:TM2D3 ^@ http://purl.uniprot.org/uniprot/U3KD52 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101811820 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:CLCN7 ^@ http://purl.uniprot.org/uniprot/U3JNL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chloride channel (TC 2.A.49) family.|||Membrane http://togogenome.org/gene/59894:GPR137B ^@ http://purl.uniprot.org/uniprot/U3KGD3 ^@ Subcellular Location Annotation ^@ Lysosome membrane|||Membrane http://togogenome.org/gene/59894:GABRA3 ^@ http://purl.uniprot.org/uniprot/A0A803VQ76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:SMIM8 ^@ http://purl.uniprot.org/uniprot/U3JJT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMIM8 family.|||Membrane http://togogenome.org/gene/59894:CRHR2 ^@ http://purl.uniprot.org/uniprot/U3JVL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Membrane http://togogenome.org/gene/59894:MAP2 ^@ http://purl.uniprot.org/uniprot/A0A803VCR2|||http://purl.uniprot.org/uniprot/A0A803VKR6|||http://purl.uniprot.org/uniprot/A0A803VZZ3|||http://purl.uniprot.org/uniprot/A0A803W4F6 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:DDX43 ^@ http://purl.uniprot.org/uniprot/A0A803V052|||http://purl.uniprot.org/uniprot/U3JX51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DEAD box helicase family.|||Cytoplasm http://togogenome.org/gene/59894:C8A ^@ http://purl.uniprot.org/uniprot/U3KCT2 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:NEUROD6 ^@ http://purl.uniprot.org/uniprot/U3KI51 ^@ Subcellular Location Annotation|||Subunit ^@ Efficient DNA binding requires dimerization with another bHLH protein.|||Nucleus http://togogenome.org/gene/59894:BIRC7 ^@ http://purl.uniprot.org/uniprot/U3K7A6 ^@ Similarity ^@ Belongs to the IAP family. http://togogenome.org/gene/59894:LGMN ^@ http://purl.uniprot.org/uniprot/A0A803VVZ0|||http://purl.uniprot.org/uniprot/U3JID3 ^@ Similarity ^@ Belongs to the peptidase C13 family. http://togogenome.org/gene/59894:GJD4 ^@ http://purl.uniprot.org/uniprot/A0A803VPV1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:FOXJ2 ^@ http://purl.uniprot.org/uniprot/A0A803WG65|||http://purl.uniprot.org/uniprot/U3JXQ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:MB ^@ http://purl.uniprot.org/uniprot/U3KF95 ^@ Function|||Similarity ^@ Belongs to the globin family.|||Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. http://togogenome.org/gene/59894:LOC101822000 ^@ http://purl.uniprot.org/uniprot/U3JPH3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101819307 ^@ http://purl.uniprot.org/uniprot/U3JLW1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 20 family. http://togogenome.org/gene/59894:RAB33B ^@ http://purl.uniprot.org/uniprot/A0A803WA27 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Rab family. http://togogenome.org/gene/59894:PROM2 ^@ http://purl.uniprot.org/uniprot/U3JBX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prominin family.|||Membrane|||microvillus membrane http://togogenome.org/gene/59894:LOC101808976 ^@ http://purl.uniprot.org/uniprot/U3JMB9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/59894:IGF1R ^@ http://purl.uniprot.org/uniprot/U3K6Y5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/59894:UBR2 ^@ http://purl.uniprot.org/uniprot/U3KDP2 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/59894:PLPP2 ^@ http://purl.uniprot.org/uniprot/U3KHJ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/59894:PLA1A ^@ http://purl.uniprot.org/uniprot/U3JS71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/59894:CD40LG ^@ http://purl.uniprot.org/uniprot/A0A803V9M2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a ligand for integrins, specifically ITGA5:ITGB1 and ITGAV:ITGB3; both integrins and the CD40 receptor are required for activation of CD40-CD40LG signaling, which have cell-type dependent effects, such as B-cell activation, NF-kappa-B signaling and anti-apoptotic signaling.|||Belongs to the tumor necrosis factor family.|||Cell surface|||Cytokine that acts as a ligand to CD40/TNFRSF5. Costimulates T-cell proliferation and cytokine production. Involved in immunoglobulin class switching.|||Homotrimer. http://togogenome.org/gene/59894:CLDN20 ^@ http://purl.uniprot.org/uniprot/U3KKK3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:PHKG1 ^@ http://purl.uniprot.org/uniprot/U3JWB6 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily.|||Hexadecamer of 4 heterotetramers, each composed of alpha, beta, gamma, and delta subunits. Alpha (PHKA1 or PHKA2) and beta (PHKB) are regulatory subunits, gamma (PHKG1 or PHKG2) is the catalytic subunit, and delta is calmodulin. http://togogenome.org/gene/59894:LOC101805755 ^@ http://purl.uniprot.org/uniprot/A0A803WDF1 ^@ Similarity ^@ Belongs to the calycin superfamily. Lipocalin family. http://togogenome.org/gene/59894:CLCN1 ^@ http://purl.uniprot.org/uniprot/U3JPJ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SAMD4A ^@ http://purl.uniprot.org/uniprot/A0A803UZX7|||http://purl.uniprot.org/uniprot/A0A803VUP1|||http://purl.uniprot.org/uniprot/U3JMF9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMAUG family.|||Cytoplasm http://togogenome.org/gene/59894:ATP9B ^@ http://purl.uniprot.org/uniprot/A0A803WAE6|||http://purl.uniprot.org/uniprot/A0A803WC89|||http://purl.uniprot.org/uniprot/U3KFW4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59894:DOCK4 ^@ http://purl.uniprot.org/uniprot/A0A803VI16 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/59894:LOC101806482 ^@ http://purl.uniprot.org/uniprot/A0A803VG22 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:ARAP1 ^@ http://purl.uniprot.org/uniprot/U3JUR2 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:COMT ^@ http://purl.uniprot.org/uniprot/U3K057 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. Cation-dependent O-methyltransferase family. http://togogenome.org/gene/59894:TNMD ^@ http://purl.uniprot.org/uniprot/U3JMS6 ^@ Similarity ^@ Belongs to the chondromodulin-1 family. http://togogenome.org/gene/59894:TMEM47 ^@ http://purl.uniprot.org/uniprot/A0A803W7P7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM47 family.|||Membrane http://togogenome.org/gene/59894:SIRT4 ^@ http://purl.uniprot.org/uniprot/U3JYR8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sirtuin family. Class II subfamily.|||Binds 1 zinc ion per subunit.|||Mitochondrion matrix|||NAD-dependent protein deacylase. Catalyzes the NAD-dependent hydrolysis of acyl groups from lysine residues. http://togogenome.org/gene/59894:LOC101815454 ^@ http://purl.uniprot.org/uniprot/A0A803VMG4|||http://purl.uniprot.org/uniprot/A0A803W854 ^@ Similarity|||Subunit ^@ Belongs to the ENDOU family.|||Monomer. http://togogenome.org/gene/59894:MME ^@ http://purl.uniprot.org/uniprot/U3JR22 ^@ Cofactor ^@ Binds 1 zinc ion per subunit. http://togogenome.org/gene/59894:TMEM182 ^@ http://purl.uniprot.org/uniprot/U3JM16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM182 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CTPS2 ^@ http://purl.uniprot.org/uniprot/U3JP35 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/59894:NR4A3 ^@ http://purl.uniprot.org/uniprot/U3JQD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:ZNF706 ^@ http://purl.uniprot.org/uniprot/A0A803VSX5 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:FAM175B ^@ http://purl.uniprot.org/uniprot/A0A803V623 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:STAT4 ^@ http://purl.uniprot.org/uniprot/A0A803W1K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the transcription factor STAT family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:PMS1 ^@ http://purl.uniprot.org/uniprot/U3JP79 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutL/HexB family. http://togogenome.org/gene/59894:GABRQ ^@ http://purl.uniprot.org/uniprot/U3K972 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:INO80D ^@ http://purl.uniprot.org/uniprot/U3JMJ7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101805825 ^@ http://purl.uniprot.org/uniprot/U3JCA3 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/59894:PISD ^@ http://purl.uniprot.org/uniprot/U3JY89 ^@ Cofactor|||Function|||PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the phosphatidylserine decarboxylase family. PSD-B subfamily. Eukaryotic type I sub-subfamily.|||Binds 1 pyruvoyl group covalently per subunit.|||Catalyzes the formation of phosphatidylethanolamine (PtdEtn) from phosphatidylserine (PtdSer). Plays a central role in phospholipid metabolism and in the interorganelle trafficking of phosphatidylserine.|||Heterodimer of a large membrane-associated beta subunit and a small pyruvoyl-containing alpha subunit.|||Is synthesized initially as an inactive proenzyme. Formation of the active enzyme involves a self-maturation process in which the active site pyruvoyl group is generated from an internal serine residue via an autocatalytic post-translational modification. Two non-identical subunits are generated from the proenzyme in this reaction, and the pyruvate is formed at the N-terminus of the alpha chain, which is derived from the carboxyl end of the proenzyme. The autoendoproteolytic cleavage occurs by a canonical serine protease mechanism, in which the side chain hydroxyl group of the serine supplies its oxygen atom to form the C-terminus of the beta chain, while the remainder of the serine residue undergoes an oxidative deamination to produce ammonia and the pyruvoyl prosthetic group on the alpha chain. During this reaction, the Ser that is part of the protease active site of the proenzyme becomes the pyruvoyl prosthetic group, which constitutes an essential element of the active site of the mature decarboxylase.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:UPP1 ^@ http://purl.uniprot.org/uniprot/U3JYD8 ^@ Function|||Similarity ^@ Belongs to the PNP/UDP phosphorylase family.|||Catalyzes the reversible phosphorylytic cleavage of uridine and deoxyuridine to uracil and ribose- or deoxyribose-1-phosphate. The produced molecules are then utilized as carbon and energy sources or in the rescue of pyrimidine bases for nucleotide synthesis. http://togogenome.org/gene/59894:ERGIC3 ^@ http://purl.uniprot.org/uniprot/U3KDG7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ERGIC family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Plays a role in transport between endoplasmic reticulum and Golgi. http://togogenome.org/gene/59894:LAP3 ^@ http://purl.uniprot.org/uniprot/U3K3N9 ^@ Similarity|||Subunit ^@ Belongs to the peptidase M17 family.|||Homohexamer. http://togogenome.org/gene/59894:KRT222 ^@ http://purl.uniprot.org/uniprot/U3JC62 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LHPP ^@ http://purl.uniprot.org/uniprot/U3JQE2|||http://purl.uniprot.org/uniprot/U3JQE3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/59894:LOC101807290 ^@ http://purl.uniprot.org/uniprot/A0A803V759 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:LOC101819100 ^@ http://purl.uniprot.org/uniprot/A0A803VFW0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:BCL2A1 ^@ http://purl.uniprot.org/uniprot/A0A803V184 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/59894:RYBP ^@ http://purl.uniprot.org/uniprot/A0A803W1P3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101814488 ^@ http://purl.uniprot.org/uniprot/U3K3Z1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101818893 ^@ http://purl.uniprot.org/uniprot/U3KIW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:LOC101807340 ^@ http://purl.uniprot.org/uniprot/A0A803V5W4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the guanylin family.|||Secreted http://togogenome.org/gene/59894:DPH2 ^@ http://purl.uniprot.org/uniprot/U3JS13 ^@ Function|||Similarity ^@ Belongs to the DPH1/DPH2 family. DPH2 subfamily.|||Required for the first step of diphthamide biosynthesis, a post-translational modification of histidine which occurs in elongation factor 2. DPH1 and DPH2 transfer a 3-amino-3-carboxypropyl (ACP) group from S-adenosyl-L-methionine (SAM) to a histidine residue, the reaction is assisted by a reduction system comprising DPH3 and a NADH-dependent reductase. Facilitates the reduction of the catalytic iron-sulfur cluster found in the DPH1 subunit. http://togogenome.org/gene/59894:SURF4 ^@ http://purl.uniprot.org/uniprot/A0A803VY86 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SURF4 family.|||Membrane http://togogenome.org/gene/59894:LOC101819599 ^@ http://purl.uniprot.org/uniprot/U3KCU2 ^@ Similarity ^@ Belongs to the SERF family. http://togogenome.org/gene/59894:CLDN11 ^@ http://purl.uniprot.org/uniprot/A0A803VBS8 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:SLC29A1 ^@ http://purl.uniprot.org/uniprot/A0A803VGS4|||http://purl.uniprot.org/uniprot/U3K9T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC29A/ENT transporter (TC 2.A.57) family.|||Membrane http://togogenome.org/gene/59894:CNOT6 ^@ http://purl.uniprot.org/uniprot/A0A803V476 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CCR4/nocturin family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:HMGCLL1 ^@ http://purl.uniprot.org/uniprot/U3JGJ6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the HMG-CoA lyase family.|||Homodimer; disulfide-linked. Can also form homotetramers.|||Mitochondrial 3-hydroxymethyl-3-methylglutaryl-CoA lyase that catalyzes a cation-dependent cleavage of (S)-3-hydroxy-3-methylglutaryl-CoA into acetyl-CoA and acetoacetate, a key step in ketogenesis. Terminal step in leucine catabolism. Ketone bodies (beta-hydroxybutyrate, acetoacetate and acetone) are essential as an alternative source of energy to glucose, as lipid precursors and as regulators of metabolism. http://togogenome.org/gene/59894:OTULIN ^@ http://purl.uniprot.org/uniprot/U3JYF0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C65 family. Otulin subfamily.|||Cytoplasm http://togogenome.org/gene/59894:LOC101809491 ^@ http://purl.uniprot.org/uniprot/U3JC51 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:PDE6B ^@ http://purl.uniprot.org/uniprot/A0A803V9A0|||http://purl.uniprot.org/uniprot/U3JRY8 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:LPIN2 ^@ http://purl.uniprot.org/uniprot/U3JUW6 ^@ Similarity ^@ Belongs to the lipin family. http://togogenome.org/gene/59894:MAPKAP1 ^@ http://purl.uniprot.org/uniprot/U3JHP0 ^@ Similarity ^@ Belongs to the SIN1 family. http://togogenome.org/gene/59894:TEF ^@ http://purl.uniprot.org/uniprot/U3KBU1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. PAR subfamily.|||Nucleus http://togogenome.org/gene/59894:NRP1 ^@ http://purl.uniprot.org/uniprot/U3JXA7 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neuropilin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:CELF2 ^@ http://purl.uniprot.org/uniprot/A0A803V3U6|||http://purl.uniprot.org/uniprot/A0A803VXR6|||http://purl.uniprot.org/uniprot/A0A803WH04|||http://purl.uniprot.org/uniprot/U3JGP9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CELF/BRUNOL family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:APOLD1 ^@ http://purl.uniprot.org/uniprot/U3KL53 ^@ Similarity ^@ Belongs to the apolipoprotein L family. http://togogenome.org/gene/59894:GPC4 ^@ http://purl.uniprot.org/uniprot/U3JGK7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/59894:PUS1 ^@ http://purl.uniprot.org/uniprot/A0A803VIQ1|||http://purl.uniprot.org/uniprot/A0A803W6P7|||http://purl.uniprot.org/uniprot/U3K0R6 ^@ Similarity ^@ Belongs to the tRNA pseudouridine synthase TruA family. http://togogenome.org/gene/59894:TWSG1 ^@ http://purl.uniprot.org/uniprot/A0A803WBT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the twisted gastrulation protein family.|||Secreted http://togogenome.org/gene/59894:GLRB ^@ http://purl.uniprot.org/uniprot/A0A803W5F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Membrane http://togogenome.org/gene/59894:ARID1B ^@ http://purl.uniprot.org/uniprot/U3KDG9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LIN9 ^@ http://purl.uniprot.org/uniprot/A0A803WFC3|||http://purl.uniprot.org/uniprot/U3KAS0 ^@ Similarity ^@ Belongs to the lin-9 family. http://togogenome.org/gene/59894:TSG101 ^@ http://purl.uniprot.org/uniprot/U3K9H6 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. UEV subfamily. http://togogenome.org/gene/59894:SUFU ^@ http://purl.uniprot.org/uniprot/U3K235 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SUFU family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:MAD1L1 ^@ http://purl.uniprot.org/uniprot/A0A803VP15|||http://purl.uniprot.org/uniprot/A0A803W0H7|||http://purl.uniprot.org/uniprot/U3KHL5 ^@ Similarity ^@ Belongs to the MAD1 family. http://togogenome.org/gene/59894:CHRNB3 ^@ http://purl.uniprot.org/uniprot/U3JRK0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:EPHX1 ^@ http://purl.uniprot.org/uniprot/U3KAY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase S33 family.|||Biotransformation enzyme that catalyzes the hydrolysis of arene and aliphatic epoxides to less reactive and more water soluble dihydrodiols by the trans addition of water.|||Endoplasmic reticulum membrane|||Microsome membrane http://togogenome.org/gene/59894:MED22 ^@ http://purl.uniprot.org/uniprot/A0A803V591 ^@ Function|||Subcellular Location Annotation ^@ Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Nucleus http://togogenome.org/gene/59894:NUP50 ^@ http://purl.uniprot.org/uniprot/A0A803VXZ9 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/59894:PAPPA ^@ http://purl.uniprot.org/uniprot/U3JRW7 ^@ Caution|||Similarity ^@ Belongs to the peptidase M43B family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101808110 ^@ http://purl.uniprot.org/uniprot/A0A803V0H4|||http://purl.uniprot.org/uniprot/U3JKN0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:MRPL43 ^@ http://purl.uniprot.org/uniprot/A0A803VKV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL43 family.|||Mitochondrion http://togogenome.org/gene/59894:ALG6 ^@ http://purl.uniprot.org/uniprot/U3KDK6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Adds the first glucose residue to the lipid-linked oligosaccharide precursor for N-linked glycosylation. Transfers glucose from dolichyl phosphate glucose (Dol-P-Glc) onto the lipid-linked oligosaccharide Man(9)GlcNAc(2)-PP-Dol.|||Belongs to the ALG6/ALG8 glucosyltransferase family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:IPPK ^@ http://purl.uniprot.org/uniprot/U3K336 ^@ Domain|||Function|||Similarity ^@ Belongs to the IPK1 type 2 family.|||Phosphorylates Ins(1,3,4,5,6)P5 at position 2 to form Ins(1,2,3,4,5,6)P6 (InsP6 or phytate).|||The EXKPK motif is conserved in inositol-pentakisphosphate 2-kinases of both family 1 and 2. http://togogenome.org/gene/59894:CNEP1R1 ^@ http://purl.uniprot.org/uniprot/A0A803VHJ6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNEP1R1 family.|||Cytoplasm|||Membrane|||Nucleus membrane http://togogenome.org/gene/59894:ANAPC10 ^@ http://purl.uniprot.org/uniprot/U3JSL0 ^@ Function|||Similarity ^@ Belongs to the APC10 family.|||Component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin-protein ligase complex that controls progression through mitosis and the G1 phase of the cell cycle. http://togogenome.org/gene/59894:SLC35E4 ^@ http://purl.uniprot.org/uniprot/A0A803VMM9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PRKCZ ^@ http://purl.uniprot.org/uniprot/U3K4C5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily. http://togogenome.org/gene/59894:TEKT2 ^@ http://purl.uniprot.org/uniprot/U3JDJ7 ^@ Similarity ^@ Belongs to the tektin family. http://togogenome.org/gene/59894:ARHGAP26 ^@ http://purl.uniprot.org/uniprot/A0A803W2M8|||http://purl.uniprot.org/uniprot/U3K2T8 ^@ Subcellular Location Annotation ^@ cytoskeleton|||focal adhesion http://togogenome.org/gene/59894:SNRPD3 ^@ http://purl.uniprot.org/uniprot/U3JXX4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the snRNP core protein family.|||Nucleus|||cytosol http://togogenome.org/gene/59894:LOC101818173 ^@ http://purl.uniprot.org/uniprot/U3K939 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Stoned B family.|||Cytoplasm|||May be involved in the endocytic machinery. http://togogenome.org/gene/59894:FERMT1 ^@ http://purl.uniprot.org/uniprot/U3K8U4 ^@ Similarity ^@ Belongs to the kindlin family. http://togogenome.org/gene/59894:ACMSD ^@ http://purl.uniprot.org/uniprot/A0A803V2Q1|||http://purl.uniprot.org/uniprot/A0A803W2W8|||http://purl.uniprot.org/uniprot/U3KH18 ^@ Function|||Similarity|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. ACMSD family.|||Converts alpha-amino-beta-carboxymuconate-epsilon-semialdehyde (ACMS) to alpha-aminomuconate semialdehyde (AMS). ACMS can be converted non-enzymatically to quinolate (QA), a key precursor of NAD, and a potent endogenous excitotoxin of neuronal cells which is implicated in the pathogenesis of various neurodegenerative disorders. In the presence of ACMSD, ACMS is converted to AMS, a benign catabolite. ACMSD ultimately controls the metabolic fate of tryptophan catabolism along the kynurenine pathway.|||Monomer. http://togogenome.org/gene/59894:MTHFR ^@ http://purl.uniprot.org/uniprot/U3K671 ^@ Similarity ^@ Belongs to the methylenetetrahydrofolate reductase family. http://togogenome.org/gene/59894:LOC101819878 ^@ http://purl.uniprot.org/uniprot/A0A803VV12|||http://purl.uniprot.org/uniprot/U3JUN4 ^@ Similarity ^@ Belongs to the zinc-containing alcohol dehydrogenase family. http://togogenome.org/gene/59894:LOC101820708 ^@ http://purl.uniprot.org/uniprot/U3JMU4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 23 family.|||Secreted http://togogenome.org/gene/59894:TMPRSS13 ^@ http://purl.uniprot.org/uniprot/U3JTP7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:SFRP4 ^@ http://purl.uniprot.org/uniprot/A0A803WAM2|||http://purl.uniprot.org/uniprot/U3JJJ5 ^@ Caution|||Similarity ^@ Belongs to the secreted frizzled-related protein (sFRP) family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101815223 ^@ http://purl.uniprot.org/uniprot/U3KIX0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:IRX1 ^@ http://purl.uniprot.org/uniprot/U3JRP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TALE/IRO homeobox family.|||Nucleus http://togogenome.org/gene/59894:FAM193A ^@ http://purl.uniprot.org/uniprot/U3K5F3 ^@ Similarity ^@ Belongs to the FAM193 family. http://togogenome.org/gene/59894:FAM26D ^@ http://purl.uniprot.org/uniprot/U3K8Z2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59894:SPATA6 ^@ http://purl.uniprot.org/uniprot/U3JRW3 ^@ Similarity ^@ Belongs to the SPATA6 family. http://togogenome.org/gene/59894:CHL1 ^@ http://purl.uniprot.org/uniprot/A0A803VZB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/59894:NR1H3 ^@ http://purl.uniprot.org/uniprot/U3JUY4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR1 subfamily.|||Nucleus http://togogenome.org/gene/59894:DHRS7B ^@ http://purl.uniprot.org/uniprot/A0A803VEW5|||http://purl.uniprot.org/uniprot/U3KH89 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:LOC101818738 ^@ http://purl.uniprot.org/uniprot/U3K4J8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:FAM73A ^@ http://purl.uniprot.org/uniprot/A0A803VCA7|||http://purl.uniprot.org/uniprot/U3JT71 ^@ Similarity ^@ Belongs to the mitoguardin family. http://togogenome.org/gene/59894:HVCN1 ^@ http://purl.uniprot.org/uniprot/U3K331 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:NADK ^@ http://purl.uniprot.org/uniprot/A0A803V6T9 ^@ Similarity ^@ Belongs to the NAD kinase family. http://togogenome.org/gene/59894:PLD1 ^@ http://purl.uniprot.org/uniprot/U3K1D4 ^@ Similarity ^@ Belongs to the phospholipase D family. http://togogenome.org/gene/59894:KIF18A ^@ http://purl.uniprot.org/uniprot/U3KCP5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:RAB32 ^@ http://purl.uniprot.org/uniprot/U3KF61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Membrane|||The small GTPases Rab are key regulators in vesicle trafficking. http://togogenome.org/gene/59894:FAM134B ^@ http://purl.uniprot.org/uniprot/A0A803W8S5|||http://purl.uniprot.org/uniprot/A0A803WF25 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RETREG family.|||Membrane http://togogenome.org/gene/59894:LUM ^@ http://purl.uniprot.org/uniprot/U3K7W5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class II subfamily.|||Binds to laminin.|||extracellular matrix http://togogenome.org/gene/59894:NIPA2 ^@ http://purl.uniprot.org/uniprot/A0A803VFT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/59894:VPS36 ^@ http://purl.uniprot.org/uniprot/U3K1M0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the VPS36 family.|||Component of the ESCRT-II complex (endosomal sorting complex required for transport II), which is required for multivesicular body (MVB) formation and sorting of endosomal cargo proteins into MVBs.|||Component of the endosomal sorting complex required for transport II (ESCRT-II).|||Cytoplasm|||Endosome http://togogenome.org/gene/59894:PRDM5 ^@ http://purl.uniprot.org/uniprot/U3K129 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TM9SF3 ^@ http://purl.uniprot.org/uniprot/U3JXM8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nonaspanin (TM9SF) (TC 9.A.2) family.|||Membrane http://togogenome.org/gene/59894:ACTN2 ^@ http://purl.uniprot.org/uniprot/U3KG99 ^@ Similarity ^@ Belongs to the alpha-actinin family. http://togogenome.org/gene/59894:ST6GALNAC2 ^@ http://purl.uniprot.org/uniprot/U3JDV8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:PIGP ^@ http://purl.uniprot.org/uniprot/U3JRM6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGP family.|||Membrane|||Part of the complex catalyzing the transfer of N-acetylglucosamine from UDP-N-acetylglucosamine to phosphatidylinositol, the first step of GPI biosynthesis. http://togogenome.org/gene/59894:NPY1R ^@ http://purl.uniprot.org/uniprot/U3K9A1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101813749 ^@ http://purl.uniprot.org/uniprot/U3KF16 ^@ Similarity ^@ Belongs to the AB hydrolase superfamily. Lipase family. http://togogenome.org/gene/59894:SERPINH1 ^@ http://purl.uniprot.org/uniprot/U3JVT8 ^@ Function|||Similarity ^@ Belongs to the serpin family.|||Binds specifically to collagen. Could be involved as a chaperone in the biosynthetic pathway of collagen. http://togogenome.org/gene/59894:LOC101815035 ^@ http://purl.uniprot.org/uniprot/A0A803WGL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dicarboxylate/amino acid:cation symporter (DAACS) (TC 2.A.23) family.|||Membrane http://togogenome.org/gene/59894:RAB27A ^@ http://purl.uniprot.org/uniprot/A0A803V1N2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rab family.|||Endosome|||Late endosome|||Membrane http://togogenome.org/gene/59894:GLI2 ^@ http://purl.uniprot.org/uniprot/U3KFK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Nucleus http://togogenome.org/gene/59894:AK6 ^@ http://purl.uniprot.org/uniprot/U3KEG2 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK6 subfamily.|||Broad-specificity nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. May have a role in nuclear energy homeostasis. Has also ATPase activity. May be involved in regulation of Cajal body (CB) formation.|||Cajal body|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Monomer and homodimer. Interacts with COIL (via C-terminus).|||nucleoplasm http://togogenome.org/gene/59894:EPHB1 ^@ http://purl.uniprot.org/uniprot/A0A803V6K9 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||dendrite http://togogenome.org/gene/59894:MIS12 ^@ http://purl.uniprot.org/uniprot/U3KL45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mis12 family.|||kinetochore http://togogenome.org/gene/59894:TRADD ^@ http://purl.uniprot.org/uniprot/A0A803V709 ^@ Subcellular Location Annotation ^@ Nucleus|||cytoskeleton http://togogenome.org/gene/59894:MELK ^@ http://purl.uniprot.org/uniprot/A0A803V465|||http://purl.uniprot.org/uniprot/U3KEV6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily. http://togogenome.org/gene/59894:ADK ^@ http://purl.uniprot.org/uniprot/U3JWW7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATP dependent phosphorylation of adenosine and other related nucleoside analogs to monophosphate derivatives.|||Belongs to the carbohydrate kinase PfkB family.|||Binds 3 Mg(2+) ions per subunit.|||Monomer.|||Nucleus http://togogenome.org/gene/59894:ECE1 ^@ http://purl.uniprot.org/uniprot/U3JM56 ^@ Function ^@ Converts big endothelin-1 to endothelin-1. http://togogenome.org/gene/59894:CHRM4 ^@ http://purl.uniprot.org/uniprot/U3KIG6 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/59894:C17H9orf78 ^@ http://purl.uniprot.org/uniprot/U3JFE5 ^@ Similarity ^@ Belongs to the TLS1 family. http://togogenome.org/gene/59894:ST8SIA5 ^@ http://purl.uniprot.org/uniprot/U3K2N1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:PSMD2 ^@ http://purl.uniprot.org/uniprot/U3K022 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S2 family.|||Binds to the intracellular domain of tumor necrosis factor type 1 receptor. The binding domain of TRAP1 and TRAP2 resides outside the death domain of TNFR1.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/59894:LOC101817074 ^@ http://purl.uniprot.org/uniprot/U3JGN4 ^@ Similarity ^@ Belongs to the GST superfamily. Alpha family. http://togogenome.org/gene/59894:TINAG ^@ http://purl.uniprot.org/uniprot/U3JGL1 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59894:SYBU ^@ http://purl.uniprot.org/uniprot/U3JUE8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TIMM23 ^@ http://purl.uniprot.org/uniprot/U3JW84 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Tim17/Tim22/Tim23 family.|||Component of the TIM23 complex, at least composed of TIM23, TIM17, TIM50 and TIM21.|||Essential component of the TIM23 complex, a complex that mediates the translocation of transit peptide-containing proteins across the mitochondrial inner membrane.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:SLITRK1 ^@ http://purl.uniprot.org/uniprot/U3KJW7 ^@ Similarity ^@ Belongs to the SLITRK family. http://togogenome.org/gene/59894:THAP1 ^@ http://purl.uniprot.org/uniprot/U3JRJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the THAP1 family.|||DNA-binding transcription regulator that regulates endothelial cell proliferation and G1/S cell-cycle progression. Specifically binds the 5'-[AT]NTNN[GT]GGCA[AGT]-3' core DNA sequence and acts by modulating expression of pRB-E2F cell-cycle target genes.|||nucleoplasm http://togogenome.org/gene/59894:PRKCQ ^@ http://purl.uniprot.org/uniprot/U3JGG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/59894:TRPC4 ^@ http://purl.uniprot.org/uniprot/U3K0H3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:COL4A1 ^@ http://purl.uniprot.org/uniprot/U3K7K7 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/59894:TNRC6C ^@ http://purl.uniprot.org/uniprot/A0A803VZZ9 ^@ Similarity ^@ Belongs to the GW182 family. http://togogenome.org/gene/59894:CCDC103 ^@ http://purl.uniprot.org/uniprot/U3JYL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the CCDC103/PR46b family.|||Cytoplasm|||Dynein-attachment factor required for cilia motility.|||Homodimer.|||flagellum http://togogenome.org/gene/59894:LOC101806316 ^@ http://purl.uniprot.org/uniprot/A0A803WAN6 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59894:CHSY1 ^@ http://purl.uniprot.org/uniprot/U3K6J4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chondroitin N-acetylgalactosaminyltransferase family.|||Golgi stack membrane|||Membrane http://togogenome.org/gene/59894:FUT9 ^@ http://purl.uniprot.org/uniprot/U3K4X5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 10 family.|||Golgi stack membrane http://togogenome.org/gene/59894:LOC101808641 ^@ http://purl.uniprot.org/uniprot/A0A803V8G2|||http://purl.uniprot.org/uniprot/U3JF55 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:NR2C1 ^@ http://purl.uniprot.org/uniprot/A0A803VG68|||http://purl.uniprot.org/uniprot/A0A803W6H4|||http://purl.uniprot.org/uniprot/U3K873 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:TUBAL3 ^@ http://purl.uniprot.org/uniprot/A0A803VCH4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:PTGES3 ^@ http://purl.uniprot.org/uniprot/U3JCD6 ^@ Similarity ^@ Belongs to the p23/wos2 family. http://togogenome.org/gene/59894:KIAA0196 ^@ http://purl.uniprot.org/uniprot/U3JIN6 ^@ Similarity ^@ Belongs to the strumpellin family. http://togogenome.org/gene/59894:ATP11B ^@ http://purl.uniprot.org/uniprot/A0A803WDK0|||http://purl.uniprot.org/uniprot/U3K0T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59894:OPRK1 ^@ http://purl.uniprot.org/uniprot/U3K6I9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled opioid receptor that functions as receptor for endogenous alpha-neoendorphins and dynorphins, but has low affinity for beta-endorphins. Also functions as receptor for various synthetic opioids and for the psychoactive diterpene salvinorin A. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling leads to the inhibition of adenylate cyclase activity. Inhibits neurotransmitter release by reducing calcium ion currents and increasing potassium ion conductance. Plays a role in the perception of pain. Plays a role in mediating reduced physical activity upon treatment with synthetic opioids. Plays a role in the regulation of salivation in response to synthetic opioids. May play a role in arousal and regulation of autonomic and neuroendocrine functions.|||Interacts with SLC9A3R1. Interacts with GABARAPL1.|||Membrane http://togogenome.org/gene/59894:GLMP ^@ http://purl.uniprot.org/uniprot/U3JNQ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GLMP family.|||Lysosome membrane|||Required to protect lysosomal transporter MFSD1 from lysosomal proteolysis and for MFSD1 lysosomal localization. http://togogenome.org/gene/59894:GSDMA ^@ http://purl.uniprot.org/uniprot/U3JCH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gasdermin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TNK2 ^@ http://purl.uniprot.org/uniprot/A0A803VZY6 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/59894:LEO1 ^@ http://purl.uniprot.org/uniprot/U3KBG3 ^@ Similarity ^@ Belongs to the LEO1 family. http://togogenome.org/gene/59894:LOC101814266 ^@ http://purl.uniprot.org/uniprot/U3JR89 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:LOC101808938 ^@ http://purl.uniprot.org/uniprot/U3JSR7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:SOSTDC1 ^@ http://purl.uniprot.org/uniprot/U3K5U4 ^@ Caution|||Similarity ^@ Belongs to the sclerostin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TMEM45A ^@ http://purl.uniprot.org/uniprot/A0A803VCP6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM45 family.|||Membrane http://togogenome.org/gene/59894:GPER1 ^@ http://purl.uniprot.org/uniprot/U3KIL2 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:ACTA2 ^@ http://purl.uniprot.org/uniprot/U3JYY8 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:PHYKPL ^@ http://purl.uniprot.org/uniprot/U3JYY7 ^@ Similarity ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59894:SPIRE1 ^@ http://purl.uniprot.org/uniprot/U3JVD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the spire family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytoskeleton http://togogenome.org/gene/59894:PPIL3 ^@ http://purl.uniprot.org/uniprot/A0A803V7A1 ^@ Function|||Similarity ^@ Belongs to the cyclophilin-type PPIase family.|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59894:GALNT10 ^@ http://purl.uniprot.org/uniprot/A0A803V2D0|||http://purl.uniprot.org/uniprot/U3K0V9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 2 family. GalNAc-T subfamily.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:TNS3 ^@ http://purl.uniprot.org/uniprot/A0A803V8M6 ^@ Similarity ^@ Belongs to the PTEN phosphatase protein family. http://togogenome.org/gene/59894:ITIH5 ^@ http://purl.uniprot.org/uniprot/U3JGI1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/59894:QPCT ^@ http://purl.uniprot.org/uniprot/U3KB49 ^@ Similarity ^@ Belongs to the glutaminyl-peptide cyclotransferase family. http://togogenome.org/gene/59894:SF3B1 ^@ http://purl.uniprot.org/uniprot/U3JNV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SF3B1 family.|||Nucleus http://togogenome.org/gene/59894:MICAL2 ^@ http://purl.uniprot.org/uniprot/A0A803WG89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mical family.|||Cytoplasm http://togogenome.org/gene/59894:TRAPPC11 ^@ http://purl.uniprot.org/uniprot/U3KB09 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAPPC11 family.|||Involved in endoplasmic reticulum to Golgi apparatus trafficking at a very early stage.|||cis-Golgi network http://togogenome.org/gene/59894:LOC101813957 ^@ http://purl.uniprot.org/uniprot/U3KLL0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:RBL1 ^@ http://purl.uniprot.org/uniprot/U3KDL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the retinoblastoma protein (RB) family.|||Nucleus http://togogenome.org/gene/59894:IST1 ^@ http://purl.uniprot.org/uniprot/U3JIY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IST1 family.|||Cytoplasmic vesicle|||Nucleus envelope http://togogenome.org/gene/59894:TRPC6 ^@ http://purl.uniprot.org/uniprot/U3JC57 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101820229 ^@ http://purl.uniprot.org/uniprot/U3K020 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:GHSR ^@ http://purl.uniprot.org/uniprot/U3K1B3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for ghrelin, coupled to G-alpha-11 proteins. Stimulates growth hormone secretion. Binds also other growth hormone releasing peptides (GHRP) (e.g. Met-enkephalin and GHRP-6) as well as non-peptide, low molecular weight secretagogues (e.g. L-692,429, MK-0677, adenosine). http://togogenome.org/gene/59894:LOC101817312 ^@ http://purl.uniprot.org/uniprot/U3KKB2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:AZIN2 ^@ http://purl.uniprot.org/uniprot/U3JCU8 ^@ Similarity ^@ Belongs to the Orn/Lys/Arg decarboxylase class-II family. http://togogenome.org/gene/59894:GAL3ST1 ^@ http://purl.uniprot.org/uniprot/A0A803VAE9 ^@ Similarity ^@ Belongs to the galactose-3-O-sulfotransferase family. http://togogenome.org/gene/59894:PARP8 ^@ http://purl.uniprot.org/uniprot/A0A803W8I6|||http://purl.uniprot.org/uniprot/U3K9S4 ^@ Similarity ^@ Belongs to the ARTD/PARP family. http://togogenome.org/gene/59894:ROR2 ^@ http://purl.uniprot.org/uniprot/U3JQB3 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. ROR subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101817916 ^@ http://purl.uniprot.org/uniprot/A0A803VCB5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101820878 ^@ http://purl.uniprot.org/uniprot/A0A803VSA6|||http://purl.uniprot.org/uniprot/U3K2Z5 ^@ Similarity|||Subunit ^@ Homodimer.|||In the C-terminal section; belongs to the phosphoglycerate mutase family. http://togogenome.org/gene/59894:ATG5 ^@ http://purl.uniprot.org/uniprot/A0A803W9K4|||http://purl.uniprot.org/uniprot/U3KAS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ATG5 family.|||Conjugated with ATG12.|||Involved in autophagic vesicle formation. Conjugation with ATG12, through a ubiquitin-like conjugating system involving ATG7 as an E1-like activating enzyme and ATG10 as an E2-like conjugating enzyme, is essential for its function. The ATG12-ATG5 conjugate acts as an E3-like enzyme which is required for lipidation of ATG8 family proteins and their association to the vesicle membranes. Involved in mitochondrial quality control after oxidative damage, and in subsequent cellular longevity. Plays a critical role in multiple aspects of lymphocyte development and is essential for both B and T lymphocyte survival and proliferation. Required for optimal processing and presentation of antigens for MHC II. Involved in the maintenance of axon morphology and membrane structures, as well as in normal adipocyte differentiation. Promotes primary ciliogenesis through removal of OFD1 from centriolar satellites and degradation of IFT20 via the autophagic pathway.|||May play an important role in the apoptotic process, possibly within the modified cytoskeleton. Its expression is a relatively late event in the apoptotic process, occurring downstream of caspase activity. Plays a crucial role in IFN-gamma-induced autophagic cell death by interacting with FADD.|||Preautophagosomal structure membrane http://togogenome.org/gene/59894:LOC101807050 ^@ http://purl.uniprot.org/uniprot/A0A803V5B1|||http://purl.uniprot.org/uniprot/U3K8T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the type I cytokine receptor family. Type 2 subfamily.|||Membrane http://togogenome.org/gene/59894:MMACHC ^@ http://purl.uniprot.org/uniprot/A0A803VCZ7 ^@ Similarity ^@ Belongs to the MMACHC family. http://togogenome.org/gene/59894:BZW2 ^@ http://purl.uniprot.org/uniprot/U3K5Q5 ^@ Similarity ^@ Belongs to the BZW family. http://togogenome.org/gene/59894:LOC101809825 ^@ http://purl.uniprot.org/uniprot/U3JC50 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:CKAP2L ^@ http://purl.uniprot.org/uniprot/A0A803V1Y1 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/59894:LOC101817193 ^@ http://purl.uniprot.org/uniprot/U3JVU2 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the DNA photolyase class-1 family.|||Binds 1 5,10-methenyltetrahydrofolate (MTHF) per subunit.|||Binds 1 FAD per subunit.|||May have a photoreceptor function. http://togogenome.org/gene/59894:INSIG2 ^@ http://purl.uniprot.org/uniprot/U3KGT8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the INSIG family.|||Endoplasmic reticulum membrane|||Mediates feedback control of cholesterol synthesis.|||Membrane http://togogenome.org/gene/59894:ZNF711 ^@ http://purl.uniprot.org/uniprot/U3JN23 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:EPHA4 ^@ http://purl.uniprot.org/uniprot/U3JW50 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome|||Membrane http://togogenome.org/gene/59894:SQLE ^@ http://purl.uniprot.org/uniprot/U3JIN4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the squalene monooxygenase family.|||Catalyzes the stereospecific oxidation of squalene to (S)-2,3-epoxysqualene, and is considered to be a rate-limiting enzyme in steroid biosynthesis.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:FAM126A ^@ http://purl.uniprot.org/uniprot/A0A803V4B5|||http://purl.uniprot.org/uniprot/A0A803VH93 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM126 family.|||Cell membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:TMEM129 ^@ http://purl.uniprot.org/uniprot/U3K5W7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM129 family.|||Membrane http://togogenome.org/gene/59894:INPP4A ^@ http://purl.uniprot.org/uniprot/A0A803V5L2|||http://purl.uniprot.org/uniprot/U3JMZ0 ^@ Similarity ^@ Belongs to the inositol 3,4-bisphosphate 4-phosphatase family. http://togogenome.org/gene/59894:MKX ^@ http://purl.uniprot.org/uniprot/U3JXF9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DGAT2 ^@ http://purl.uniprot.org/uniprot/A0A803WER3|||http://purl.uniprot.org/uniprot/U3KBN9 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the diacylglycerol acyltransferase family.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:PICALM ^@ http://purl.uniprot.org/uniprot/A0A803VR32|||http://purl.uniprot.org/uniprot/A0A803W5G6 ^@ Similarity ^@ Belongs to the PICALM/SNAP91 family. http://togogenome.org/gene/59894:PKN3 ^@ http://purl.uniprot.org/uniprot/U3JFC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/59894:SLC6A20 ^@ http://purl.uniprot.org/uniprot/A0A803VIT7|||http://purl.uniprot.org/uniprot/U3JJ04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:ZP1 ^@ http://purl.uniprot.org/uniprot/U3KC80 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CYFIP2 ^@ http://purl.uniprot.org/uniprot/A0A803VE00|||http://purl.uniprot.org/uniprot/U3K162 ^@ Similarity ^@ Belongs to the CYFIP family. http://togogenome.org/gene/59894:ATP6V1G3 ^@ http://purl.uniprot.org/uniprot/A0A803VRZ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the V-ATPase G subunit family.|||Subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59894:PDE10A ^@ http://purl.uniprot.org/uniprot/U3KCJ2 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:IFNG ^@ http://purl.uniprot.org/uniprot/U3K651 ^@ Function|||Similarity|||Subunit ^@ Belongs to the type II (or gamma) interferon family.|||Homodimer.|||Produced by lymphocytes activated by specific antigens or mitogens. IFN-gamma, in addition to having antiviral activity, has important immunoregulatory functions. It is a potent activator of macrophages, it has antiproliferative effects on transformed cells and it can potentiate the antiviral and antitumor effects of the type I interferons. http://togogenome.org/gene/59894:HNF4A ^@ http://purl.uniprot.org/uniprot/A0A803W2I4|||http://purl.uniprot.org/uniprot/U3JRR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:DPYSL2 ^@ http://purl.uniprot.org/uniprot/U3K9V5 ^@ Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. http://togogenome.org/gene/59894:SEC23B ^@ http://purl.uniprot.org/uniprot/U3JYY4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC23 subfamily.|||COPII-coated vesicle membrane|||Component of the coat protein complex II (COPII) which promotes the formation of transport vesicles from the endoplasmic reticulum (ER). The coat has two main functions, the physical deformation of the endoplasmic reticulum membrane into vesicles and the selection of cargo molecules.|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:PHYHIPL ^@ http://purl.uniprot.org/uniprot/A0A803VDL6|||http://purl.uniprot.org/uniprot/U3JHT7 ^@ Similarity ^@ Belongs to the FAM13 family.|||Belongs to the PHYHIP family. http://togogenome.org/gene/59894:RNF146 ^@ http://purl.uniprot.org/uniprot/U3KLM2 ^@ Domain|||Function|||PTM|||Subcellular Location Annotation ^@ E3 ubiquitin-protein ligase that specifically binds poly-ADP-ribosylated proteins and mediates their ubiquitination and subsequent degradation.|||The WWE domain mediates non-covalent poly(ADP-ribose)-binding.|||Ubiquitinated; autoubiquitinated.|||cytosol http://togogenome.org/gene/59894:HSPA4 ^@ http://purl.uniprot.org/uniprot/U3K2S2 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the heat shock protein 70 family.|||Cytoplasm|||Interacts with TJP1/ZO-1. http://togogenome.org/gene/59894:N4BP3 ^@ http://purl.uniprot.org/uniprot/U3K293 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the N4BP3 family.|||Cytoplasmic vesicle|||Vesicle|||axon|||dendrite http://togogenome.org/gene/59894:SH3RF1 ^@ http://purl.uniprot.org/uniprot/U3KA24 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SH3RF family.|||lamellipodium|||perinuclear region|||trans-Golgi network http://togogenome.org/gene/59894:CHRM2 ^@ http://purl.uniprot.org/uniprot/A0A803VUS7|||http://purl.uniprot.org/uniprot/U3JCP0 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. http://togogenome.org/gene/59894:EEF1AKMT1 ^@ http://purl.uniprot.org/uniprot/U3K265 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. EFM5 family.|||Cytoplasm|||Protein-lysine methyltransferase that selectively catalyzes the trimethylation of EEF1A at 'Lys-79'.|||Was originally thought to be an N(6)-adenine-specific DNA methyltransferase based on primary sequence and predicted secondary structure. http://togogenome.org/gene/59894:BCL2L13 ^@ http://purl.uniprot.org/uniprot/U3K4U1 ^@ Similarity ^@ Belongs to the Bcl-2 family. http://togogenome.org/gene/59894:FOXO3 ^@ http://purl.uniprot.org/uniprot/A0A803VC52 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:HMBS ^@ http://purl.uniprot.org/uniprot/U3K5C2 ^@ Similarity ^@ Belongs to the HMBS family. http://togogenome.org/gene/59894:EPC1 ^@ http://purl.uniprot.org/uniprot/A0A803V1K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/59894:CANX ^@ http://purl.uniprot.org/uniprot/U3JZ99 ^@ Similarity ^@ Belongs to the calreticulin family. http://togogenome.org/gene/59894:CDC42 ^@ http://purl.uniprot.org/uniprot/A0A803WGM0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Rho family. CDC42 subfamily.|||Cell membrane|||Membrane|||Midbody|||Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. http://togogenome.org/gene/59894:GFRA1 ^@ http://purl.uniprot.org/uniprot/U3JHR4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ 2 molecules of GDNFR-alpha are thought to form a complex with the disulfide-linked GDNF dimer and with 2 molecules of RET.|||Belongs to the GDNFR family.|||Cell membrane|||Membrane|||Receptor for GDNF. Mediates the GDNF-induced autophosphorylation and activation of the RET receptor. http://togogenome.org/gene/59894:RHCE ^@ http://purl.uniprot.org/uniprot/U3JCG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/59894:ACSF2 ^@ http://purl.uniprot.org/uniprot/U3JEY2 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:LOC101819832 ^@ http://purl.uniprot.org/uniprot/U3KHP6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:LOC101819516 ^@ http://purl.uniprot.org/uniprot/A0A803VCK4 ^@ Similarity ^@ Belongs to the perilipin family. http://togogenome.org/gene/59894:RIC8A ^@ http://purl.uniprot.org/uniprot/U3KA99 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the synembryn family.|||Cytoplasm|||Guanine nucleotide exchange factor (GEF), which can activate some, but not all, G-alpha proteins by exchanging bound GDP for free GTP.|||Interacts with some GDP-bound G alpha proteins. Does not interact with G-alpha proteins when they are in complex with subunits beta and gamma. http://togogenome.org/gene/59894:CREB3L2 ^@ http://purl.uniprot.org/uniprot/U3JCM1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bZIP family. ATF subfamily.|||Binds DNA as a dimer.|||Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/59894:BRINP2 ^@ http://purl.uniprot.org/uniprot/U3K0S6 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/59894:XRN1 ^@ http://purl.uniprot.org/uniprot/U3JX22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the 5'-3' exonuclease family.|||Cytoplasm http://togogenome.org/gene/59894:LRRFIP1 ^@ http://purl.uniprot.org/uniprot/A0A803V4N4|||http://purl.uniprot.org/uniprot/A0A803VR93|||http://purl.uniprot.org/uniprot/A0A803WBK8|||http://purl.uniprot.org/uniprot/A0A803WC85|||http://purl.uniprot.org/uniprot/U3KE95 ^@ Similarity ^@ Belongs to the LRRFIP family. http://togogenome.org/gene/59894:SRSF4 ^@ http://purl.uniprot.org/uniprot/U3JF46 ^@ Similarity ^@ Belongs to the splicing factor SR family. http://togogenome.org/gene/59894:EIF2S2 ^@ http://purl.uniprot.org/uniprot/A0A803V495 ^@ Similarity ^@ Belongs to the eIF-2-beta/eIF-5 family. http://togogenome.org/gene/59894:PIGW ^@ http://purl.uniprot.org/uniprot/U3KKY8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGW family.|||Endoplasmic reticulum membrane|||Membrane|||Probable acetyltransferase, which acetylates the inositol ring of phosphatidylinositol during biosynthesis of GPI-anchor. http://togogenome.org/gene/59894:PPA1 ^@ http://purl.uniprot.org/uniprot/U3KDV2 ^@ Similarity ^@ Belongs to the PPase family. http://togogenome.org/gene/59894:MTMR3 ^@ http://purl.uniprot.org/uniprot/A0A803V1C8|||http://purl.uniprot.org/uniprot/A0A803V2K6|||http://purl.uniprot.org/uniprot/A0A803VBD3|||http://purl.uniprot.org/uniprot/U3JWZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:RTN4 ^@ http://purl.uniprot.org/uniprot/A0A803V3R4 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:TTLL1 ^@ http://purl.uniprot.org/uniprot/U3JW17 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tubulin polyglutamylase family.|||cilium basal body http://togogenome.org/gene/59894:FAM114A1 ^@ http://purl.uniprot.org/uniprot/U3K3W7 ^@ Similarity ^@ Belongs to the FAM114 family. http://togogenome.org/gene/59894:CXCR4 ^@ http://purl.uniprot.org/uniprot/U3KH57 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Early endosome|||Endosome|||Late endosome|||Lysosome|||Membrane http://togogenome.org/gene/59894:ATG2B ^@ http://purl.uniprot.org/uniprot/U3JIN7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG2 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Preautophagosomal structure membrane http://togogenome.org/gene/59894:LOC101818482 ^@ http://purl.uniprot.org/uniprot/U3KLM9 ^@ Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Interacts with ATP6V0C.|||Membrane http://togogenome.org/gene/59894:LOC101818606 ^@ http://purl.uniprot.org/uniprot/U3JZ50 ^@ Similarity ^@ Belongs to the type-B carboxylesterase/lipase family. http://togogenome.org/gene/59894:PTPRG ^@ http://purl.uniprot.org/uniprot/U3KFI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 5 subfamily.|||Membrane http://togogenome.org/gene/59894:MYOZ3 ^@ http://purl.uniprot.org/uniprot/U3K029 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/59894:NKX6-3 ^@ http://purl.uniprot.org/uniprot/U3JVA1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ACSF3 ^@ http://purl.uniprot.org/uniprot/U3JKV5 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:LOC101816251 ^@ http://purl.uniprot.org/uniprot/U3KKR5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:PROC ^@ http://purl.uniprot.org/uniprot/A0A803VJE1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:LOC101812631 ^@ http://purl.uniprot.org/uniprot/U3JVP0 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:ATP7B ^@ http://purl.uniprot.org/uniprot/U3K1J5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IB subfamily.|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:PPP3CB ^@ http://purl.uniprot.org/uniprot/A0A803V7L5|||http://purl.uniprot.org/uniprot/U3JX98 ^@ Similarity ^@ Belongs to the PPP phosphatase family. PP-2B subfamily. http://togogenome.org/gene/59894:CAPN3 ^@ http://purl.uniprot.org/uniprot/A0A803VGL6|||http://purl.uniprot.org/uniprot/U3JT66 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C2 family.|||Calcium-regulated non-lysosomal thiol-protease.|||Cytoplasm|||Homodimer.|||nucleolus http://togogenome.org/gene/59894:TMEM263 ^@ http://purl.uniprot.org/uniprot/U3KG32 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM263 family.|||Membrane http://togogenome.org/gene/59894:SPON2 ^@ http://purl.uniprot.org/uniprot/U3K637 ^@ Subcellular Location Annotation ^@ extracellular matrix http://togogenome.org/gene/59894:FGFR1OP2 ^@ http://purl.uniprot.org/uniprot/A0A803VNA9 ^@ Similarity ^@ Belongs to the SIKE family. http://togogenome.org/gene/59894:TMED2 ^@ http://purl.uniprot.org/uniprot/U3K3T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EMP24/GP25L family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Membrane|||cis-Golgi network membrane http://togogenome.org/gene/59894:LARP7 ^@ http://purl.uniprot.org/uniprot/A0A803VW21|||http://purl.uniprot.org/uniprot/U3JE03 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LARP7 family.|||nucleoplasm http://togogenome.org/gene/59894:FZR1 ^@ http://purl.uniprot.org/uniprot/A0A803VCT4 ^@ Similarity ^@ Belongs to the WD repeat CDC20/Fizzy family. http://togogenome.org/gene/59894:PGM3 ^@ http://purl.uniprot.org/uniprot/U3JJ60 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the phosphohexose mutase family.|||Binds 1 Mg(2+) ion per subunit.|||Catalyzes the conversion of GlcNAc-6-P into GlcNAc-1-P during the synthesis of uridine diphosphate/UDP-GlcNAc, a sugar nucleotide critical to multiple glycosylation pathways including protein N- and O-glycosylation. http://togogenome.org/gene/59894:GRK4 ^@ http://purl.uniprot.org/uniprot/U3K5B5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/59894:MTMR7 ^@ http://purl.uniprot.org/uniprot/A0A803WFD2|||http://purl.uniprot.org/uniprot/U3K9Z7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily.|||Cytoplasm http://togogenome.org/gene/59894:ST6GAL2 ^@ http://purl.uniprot.org/uniprot/A0A803V3N8|||http://purl.uniprot.org/uniprot/A0A803VF48 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:TAF2 ^@ http://purl.uniprot.org/uniprot/A0A803V9B4|||http://purl.uniprot.org/uniprot/U3JI55 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TAF2 family.|||Nucleus http://togogenome.org/gene/59894:SF3B5 ^@ http://purl.uniprot.org/uniprot/U3KKS3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SF3B5 family.|||Component of the spliceosome B complex.|||Nucleus http://togogenome.org/gene/59894:NPHS2 ^@ http://purl.uniprot.org/uniprot/U3K0D9 ^@ Similarity ^@ Belongs to the band 7/mec-2 family. http://togogenome.org/gene/59894:LOC101813301 ^@ http://purl.uniprot.org/uniprot/U3KHS5 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/59894:PSKH1 ^@ http://purl.uniprot.org/uniprot/U3JX63 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:MED16 ^@ http://purl.uniprot.org/uniprot/U3KHN9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 16 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59894:SSTR5 ^@ http://purl.uniprot.org/uniprot/U3KIC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101814529 ^@ http://purl.uniprot.org/uniprot/U3KCE1 ^@ Similarity ^@ Belongs to the peptidase S33 family. http://togogenome.org/gene/59894:SLC39A10 ^@ http://purl.uniprot.org/uniprot/U3JP03 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:NEIL2 ^@ http://purl.uniprot.org/uniprot/U3JIK9 ^@ Similarity ^@ Belongs to the FPG family. http://togogenome.org/gene/59894:FAM161A ^@ http://purl.uniprot.org/uniprot/U3K8V8 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/59894:SLC35E3 ^@ http://purl.uniprot.org/uniprot/A0A803VZU5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101815555 ^@ http://purl.uniprot.org/uniprot/U3JET8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101807840 ^@ http://purl.uniprot.org/uniprot/U3JW15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR2 subfamily.|||Nucleus http://togogenome.org/gene/59894:NR2C2 ^@ http://purl.uniprot.org/uniprot/U3KGX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:AIM1 ^@ http://purl.uniprot.org/uniprot/A0A803VAC7|||http://purl.uniprot.org/uniprot/A0A803VMI7 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/59894:DNAJB14 ^@ http://purl.uniprot.org/uniprot/A0A803VE50 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SOX2 ^@ http://purl.uniprot.org/uniprot/U3KIZ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101811233 ^@ http://purl.uniprot.org/uniprot/U3JU83 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/59894:LOC101806389 ^@ http://purl.uniprot.org/uniprot/U3JKQ8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:HTR5A ^@ http://purl.uniprot.org/uniprot/A0A803VEJ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TCTEX1D4 ^@ http://purl.uniprot.org/uniprot/U3KI88 ^@ Similarity ^@ Belongs to the dynein light chain Tctex-type family. http://togogenome.org/gene/59894:LOC101814041 ^@ http://purl.uniprot.org/uniprot/U3JZ95 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the metallo-dependent hydrolases superfamily. Peptidase M19 family.|||Homodimer; disulfide-linked.|||Membrane http://togogenome.org/gene/59894:CPZ ^@ http://purl.uniprot.org/uniprot/U3K512 ^@ Caution|||Similarity ^@ Belongs to the peptidase M14 family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GLI3 ^@ http://purl.uniprot.org/uniprot/U3JRB6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GLI C2H2-type zinc-finger protein family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:GPD1L ^@ http://purl.uniprot.org/uniprot/A0A803W2P1|||http://purl.uniprot.org/uniprot/U3K3D3 ^@ Similarity ^@ Belongs to the NAD-dependent glycerol-3-phosphate dehydrogenase family. http://togogenome.org/gene/59894:GADD45G ^@ http://purl.uniprot.org/uniprot/A0A803W089 ^@ Similarity ^@ Belongs to the GADD45 family. http://togogenome.org/gene/59894:NCOA3 ^@ http://purl.uniprot.org/uniprot/U3KEK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SRC/p160 nuclear receptor coactivator family.|||Nucleus http://togogenome.org/gene/59894:RBM5 ^@ http://purl.uniprot.org/uniprot/U3K2F5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RBM5/RBM10 family.|||Nucleus http://togogenome.org/gene/59894:POLR2F ^@ http://purl.uniprot.org/uniprot/U3KE37 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the archaeal Rpo6/eukaryotic RPB6 RNA polymerase subunit family.|||Component of the RNA polymerase I (Pol I), RNA polymerase II (Pol II) and RNA polymerase III (Pol III) complexes consisting of at least 13, 12 and 17 subunits, respectively.|||Nucleus http://togogenome.org/gene/59894:PDGFD ^@ http://purl.uniprot.org/uniprot/A0A803V5H5|||http://purl.uniprot.org/uniprot/U3JCC3 ^@ Caution|||Subunit ^@ Homodimer; disulfide-linked. Interacts with PDGFRB homodimers, and with heterodimers formed by PDGFRA and PDGFRB.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:EPYC ^@ http://purl.uniprot.org/uniprot/U3K7V2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the small leucine-rich proteoglycan (SLRP) family. SLRP class III subfamily.|||extracellular matrix http://togogenome.org/gene/59894:ANKRD13B ^@ http://purl.uniprot.org/uniprot/A0A803WBS0|||http://purl.uniprot.org/uniprot/U3JUQ0 ^@ Function|||Subcellular Location Annotation ^@ Endosome|||Late endosome|||Membrane|||Ubiquitin-binding protein that specifically recognizes and binds 'Lys-63'-linked ubiquitin. Does not bind 'Lys-48'-linked ubiquitin. Positively regulates the internalization of ligand-activated EGFR by binding to the Ub moiety of ubiquitinated EGFR at the cell membrane. http://togogenome.org/gene/59894:RRAGD ^@ http://purl.uniprot.org/uniprot/U3JK33 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GTR/RAG GTP-binding protein family.|||Cytoplasm|||Guanine nucleotide-binding protein that plays a crucial role in the cellular response to amino acid availability through regulation of the mTORC1 signaling cascade.|||Lysosome http://togogenome.org/gene/59894:NR2E3 ^@ http://purl.uniprot.org/uniprot/U3K518 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:LOC101812532 ^@ http://purl.uniprot.org/uniprot/A0A803VAC1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ADCY8 ^@ http://purl.uniprot.org/uniprot/U3JIS7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59894:ENPP6 ^@ http://purl.uniprot.org/uniprot/U3KB24 ^@ Similarity ^@ Belongs to the nucleotide pyrophosphatase/phosphodiesterase family. http://togogenome.org/gene/59894:ACO2 ^@ http://purl.uniprot.org/uniprot/A0A803VP94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the aconitase/IPM isomerase family.|||Binds 1 [4Fe-4S] cluster per subunit.|||Catalyzes the isomerization of citrate to isocitrate via cis-aconitate.|||Mitochondrion http://togogenome.org/gene/59894:THBS2 ^@ http://purl.uniprot.org/uniprot/U3JKF0 ^@ Caution|||Similarity ^@ Belongs to the thrombospondin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:MTG2 ^@ http://purl.uniprot.org/uniprot/U3K7Q1 ^@ Similarity ^@ Belongs to the TRAFAC class OBG-HflX-like GTPase superfamily. OBG GTPase family. http://togogenome.org/gene/59894:CYSLTR1 ^@ http://purl.uniprot.org/uniprot/U3KKK5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101806546 ^@ http://purl.uniprot.org/uniprot/U3KFA0|||http://purl.uniprot.org/uniprot/U3KFA3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the tubulin family.|||Dimer of alpha and beta chains. A typical microtubule is a hollow water-filled tube with an outer diameter of 25 nm and an inner diameter of 15 nM. Alpha-beta heterodimers associate head-to-tail to form protofilaments running lengthwise along the microtubule wall with the beta-tubulin subunit facing the microtubule plus end conferring a structural polarity. Microtubules usually have 13 protofilaments but different protofilament numbers can be found in some organisms and specialized cells.|||Tubulin is the major constituent of microtubules, a cylinder consisting of laterally associated linear protofilaments composed of alpha- and beta-tubulin heterodimers. Microtubules grow by the addition of GTP-tubulin dimers to the microtubule end, where a stabilizing cap forms. Below the cap, tubulin dimers are in GDP-bound state, owing to GTPase activity of alpha-tubulin.|||cytoskeleton http://togogenome.org/gene/59894:DTD1 ^@ http://purl.uniprot.org/uniprot/U3JYZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DTD family.|||Cytoplasm http://togogenome.org/gene/59894:SLC5A12 ^@ http://purl.uniprot.org/uniprot/A0A803WG58|||http://purl.uniprot.org/uniprot/U3JK54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:GAB2 ^@ http://purl.uniprot.org/uniprot/U3JYY5 ^@ Similarity ^@ Belongs to the GAB family. http://togogenome.org/gene/59894:GLYCTK ^@ http://purl.uniprot.org/uniprot/A0A803WGT1 ^@ Similarity ^@ Belongs to the glycerate kinase type-2 family. http://togogenome.org/gene/59894:MAS1 ^@ http://purl.uniprot.org/uniprot/U3KLQ4 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:SRC ^@ http://purl.uniprot.org/uniprot/U3JSL6|||http://purl.uniprot.org/uniprot/U3JSM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:GJA5 ^@ http://purl.uniprot.org/uniprot/U3KJZ3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Alpha-type (group II) subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:GRK6 ^@ http://purl.uniprot.org/uniprot/U3K273 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/59894:LOC101815920 ^@ http://purl.uniprot.org/uniprot/U3KC86 ^@ Similarity ^@ Belongs to the C/M/P thioester hydrolase family. http://togogenome.org/gene/59894:ELAVL4 ^@ http://purl.uniprot.org/uniprot/A0A803VB94|||http://purl.uniprot.org/uniprot/A0A803VK91|||http://purl.uniprot.org/uniprot/A0A803VNT0|||http://purl.uniprot.org/uniprot/A0A803W3Z5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM elav family.|||Cytoplasm|||Perikaryon|||axon|||dendrite|||growth cone http://togogenome.org/gene/59894:LOC101817858 ^@ http://purl.uniprot.org/uniprot/U3KKG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59894:GDNF ^@ http://purl.uniprot.org/uniprot/U3JH73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family. GDNF subfamily.|||Secreted http://togogenome.org/gene/59894:DPYS ^@ http://purl.uniprot.org/uniprot/U3JU45 ^@ PTM|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family.|||Carbamylation allows a single lysine to coordinate two divalent metal cations. http://togogenome.org/gene/59894:NKD1 ^@ http://purl.uniprot.org/uniprot/A0A803VG47|||http://purl.uniprot.org/uniprot/U3JBC9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKD family.|||Cell autonomous antagonist of the canonical Wnt signaling pathway.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:BIRC2 ^@ http://purl.uniprot.org/uniprot/U3JC71 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ADRA1B ^@ http://purl.uniprot.org/uniprot/U3K2L8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cytoplasm|||Membrane|||This alpha-adrenergic receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. Its effect is mediated by G(q) and G(11) proteins. Nuclear ADRA1A-ADRA1B heterooligomers regulate phenylephrine (PE)-stimulated ERK signaling in cardiac myocytes.|||caveola http://togogenome.org/gene/59894:UBP1 ^@ http://purl.uniprot.org/uniprot/U3JQZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the grh/CP2 family. CP2 subfamily.|||Nucleus http://togogenome.org/gene/59894:SLC25A48 ^@ http://purl.uniprot.org/uniprot/U3JZY6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:TOP1 ^@ http://purl.uniprot.org/uniprot/U3JSR3 ^@ Function|||Similarity ^@ Belongs to the type IB topoisomerase family.|||Releases the supercoiling and torsional tension of DNA introduced during the DNA replication and transcription by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at the specific target site 5'-[CT]CCTTp site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA-(3'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 5'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand thus removing DNA supercoils. Finally, in the religation step, the DNA 5'-OH attacks the covalent intermediate to expel the active-site tyrosine and restore the DNA phosphodiester backbone. http://togogenome.org/gene/59894:PLOD2 ^@ http://purl.uniprot.org/uniprot/A0A803V590|||http://purl.uniprot.org/uniprot/U3JX88 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:GPR89B ^@ http://purl.uniprot.org/uniprot/U3JFJ9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Golgi pH regulator (TC 1.A.38) family.|||Membrane http://togogenome.org/gene/59894:NKAIN3 ^@ http://purl.uniprot.org/uniprot/U3JSL2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LMOD1 ^@ http://purl.uniprot.org/uniprot/U3JI89 ^@ Subcellular Location Annotation ^@ cytoskeleton|||sarcomere http://togogenome.org/gene/59894:PGD ^@ http://purl.uniprot.org/uniprot/U3JXN8 ^@ Function|||Similarity|||Subunit ^@ Belongs to the 6-phosphogluconate dehydrogenase family.|||Catalyzes the oxidative decarboxylation of 6-phosphogluconate to ribulose 5-phosphate and CO(2), with concomitant reduction of NADP to NADPH.|||Homodimer. http://togogenome.org/gene/59894:WDFY1 ^@ http://purl.uniprot.org/uniprot/A0A803V4N5 ^@ Subcellular Location Annotation ^@ Early endosome|||Endosome http://togogenome.org/gene/59894:SAP18 ^@ http://purl.uniprot.org/uniprot/A0A803V4P6 ^@ Similarity ^@ Belongs to the SAP18 family. http://togogenome.org/gene/59894:HOXD4 ^@ http://purl.uniprot.org/uniprot/A0A803VK65 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Antp homeobox family.|||Nucleus http://togogenome.org/gene/59894:TSPAN8 ^@ http://purl.uniprot.org/uniprot/U3K6T7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:ARCN1 ^@ http://purl.uniprot.org/uniprot/U3K5P3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adaptor complexes medium subunit family. Delta-COP subfamily.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex that consists of at least the alpha, beta, beta', gamma, delta, epsilon and zeta subunits.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59894:MIEF2 ^@ http://purl.uniprot.org/uniprot/U3KH15 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:PPP1R14D ^@ http://purl.uniprot.org/uniprot/A0A803W800 ^@ Similarity ^@ Belongs to the PP1 inhibitor family. http://togogenome.org/gene/59894:SLC5A7 ^@ http://purl.uniprot.org/uniprot/U3JLS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:MAP1LC3A ^@ http://purl.uniprot.org/uniprot/U3KDI2 ^@ Similarity ^@ Belongs to the ATG8 family. http://togogenome.org/gene/59894:GALM ^@ http://purl.uniprot.org/uniprot/U3JI46 ^@ Similarity ^@ Belongs to the aldose epimerase family. http://togogenome.org/gene/59894:SDR16C5 ^@ http://purl.uniprot.org/uniprot/U3K6U3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:SAMD8 ^@ http://purl.uniprot.org/uniprot/U3JWU6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sphingomyelin synthase family.|||Membrane http://togogenome.org/gene/59894:BRINP1 ^@ http://purl.uniprot.org/uniprot/A0A803VLR0 ^@ Similarity ^@ Belongs to the BRINP family. http://togogenome.org/gene/59894:ABCD3 ^@ http://purl.uniprot.org/uniprot/A0A803WEG2|||http://purl.uniprot.org/uniprot/U3JI31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCD family. Peroxisomal fatty acyl CoA transporter (TC 3.A.1.203) subfamily.|||Membrane|||Peroxisome membrane http://togogenome.org/gene/59894:PTBP1 ^@ http://purl.uniprot.org/uniprot/U3KHN1 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:RGR ^@ http://purl.uniprot.org/uniprot/U3JWD9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CDC25A ^@ http://purl.uniprot.org/uniprot/U3JH16 ^@ Function|||Similarity ^@ Belongs to the MPI phosphatase family.|||Functions as a dosage-dependent inducer in mitotic control. Tyrosine protein phosphatase required for progression of the cell cycle. http://togogenome.org/gene/59894:FAM19A1 ^@ http://purl.uniprot.org/uniprot/U3KFY2 ^@ Similarity ^@ Belongs to the TAFA family. http://togogenome.org/gene/59894:MYOZ2 ^@ http://purl.uniprot.org/uniprot/U3JDS4 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/59894:ADORA2A ^@ http://purl.uniprot.org/uniprot/A0A803VML4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for adenosine. The activity of this receptor is mediated by G proteins which activate adenylyl cyclase. http://togogenome.org/gene/59894:LOC101809325 ^@ http://purl.uniprot.org/uniprot/U3JPB3 ^@ Similarity ^@ Belongs to the fatty acid desaturase type 1 family. http://togogenome.org/gene/59894:AARS2 ^@ http://purl.uniprot.org/uniprot/A0A803VK82|||http://purl.uniprot.org/uniprot/U3K9N8 ^@ Cofactor|||Domain|||Function|||Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family. Alax-L subfamily.|||Binds 1 zinc ion per subunit.|||Catalyzes the attachment of alanine to tRNA(Ala) in a two-step reaction: alanine is first activated by ATP to form Ala-AMP and then transferred to the acceptor end of tRNA(Ala). Also edits incorrectly charged tRNA(Ala) via its editing domain.|||Consists of three domains; the N-terminal catalytic domain, the editing domain and the C-terminal C-Ala domain. The editing domain removes incorrectly charged amino acids, while the C-Ala domain, along with tRNA(Ala), serves as a bridge to cooperatively bring together the editing and aminoacylation centers thus stimulating deacylation of misacylated tRNAs.|||Monomer. Interacts with ANKRD16; the interaction is direct. http://togogenome.org/gene/59894:SGSM3 ^@ http://purl.uniprot.org/uniprot/U3KCD1 ^@ Similarity ^@ Belongs to the small G protein signaling modulator family. http://togogenome.org/gene/59894:DLK1 ^@ http://purl.uniprot.org/uniprot/U3JJ67 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:IFRD1 ^@ http://purl.uniprot.org/uniprot/U3K4E4 ^@ Similarity ^@ Belongs to the IFRD family. http://togogenome.org/gene/59894:USP16 ^@ http://purl.uniprot.org/uniprot/U3JUZ4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase C19 family. USP16 subfamily.|||Homotetramer.|||Nucleus|||Specifically deubiquitinates 'Lys-120' of histone H2A (H2AK119Ub), a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Deubiquitination of histone H2A is a prerequisite for subsequent phosphorylation at 'Ser-11' of histone H3 (H3S10ph), and is required for chromosome segregation when cells enter into mitosis. Regulates Hox gene expression via histone H2A deubiquitination. Prefers nucleosomal substrates. Does not deubiquitinate histone H2B.|||The UBP-type zinc finger binds 3 zinc ions that form a pair of cross-braced ring fingers encapsulated within a third zinc finger in the primary structure. It recognizes the C-terminal tail of free ubiquitin. http://togogenome.org/gene/59894:USP7 ^@ http://purl.uniprot.org/uniprot/A0A803V8K4|||http://purl.uniprot.org/uniprot/U3JN08 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:AP1M1 ^@ http://purl.uniprot.org/uniprot/A0A803VT56 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adaptor complexes medium subunit family.|||Golgi apparatus|||Subunit of clathrin-associated adaptor protein complex 1 that plays a role in protein sorting in the trans-Golgi network (TGN) and endosomes. The AP complexes mediate the recruitment of clathrin to membranes and the recognition of sorting signals within the cytosolic tails of transmembrane cargo molecules.|||clathrin-coated vesicle membrane http://togogenome.org/gene/59894:LOC101816877 ^@ http://purl.uniprot.org/uniprot/A0A803W4S5|||http://purl.uniprot.org/uniprot/U3K6I3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Associates with MYD88 and IRAK2 to form a ternary complex called the Myddosome.|||Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. Pelle subfamily.|||Cytoplasm|||Serine/threonine-protein kinase that plays a critical role in initiating innate immune response against foreign pathogens. http://togogenome.org/gene/59894:EDNRA ^@ http://purl.uniprot.org/uniprot/A0A803VXQ9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with HDAC7 and KAT5.|||Membrane|||Receptor for endothelin-1. Mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. The rank order of binding affinities for ET-A is: ET1 > ET2 >> ET3. http://togogenome.org/gene/59894:SMAD1 ^@ http://purl.uniprot.org/uniprot/U3JSK3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dwarfin/SMAD family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SNAP25 ^@ http://purl.uniprot.org/uniprot/U3K932 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||Cell membrane|||Plays an important role in the synaptic function of specific neuronal systems. Associates with proteins involved in vesicle docking and membrane fusion.|||synaptosome http://togogenome.org/gene/59894:PLEKHJ1 ^@ http://purl.uniprot.org/uniprot/U3KH78 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sesquipedalian family.|||Early endosome|||Plays a role in endocytic trafficking. Required for receptor recycling from endosomes, both to the trans-Golgi network and the plasma membrane.|||Recycling endosome|||clathrin-coated vesicle|||trans-Golgi network http://togogenome.org/gene/59894:MAGOH ^@ http://purl.uniprot.org/uniprot/U3JT84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mago nashi family.|||Nucleus http://togogenome.org/gene/59894:PPARD ^@ http://purl.uniprot.org/uniprot/U3JM40 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family.|||Nucleus http://togogenome.org/gene/59894:S1PR3 ^@ http://purl.uniprot.org/uniprot/U3KJ28 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:VPS13D ^@ http://purl.uniprot.org/uniprot/U3K5U8 ^@ Similarity ^@ Belongs to the VPS13 family. http://togogenome.org/gene/59894:DAPK3 ^@ http://purl.uniprot.org/uniprot/U3JDM8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:HSP90AB1 ^@ http://purl.uniprot.org/uniprot/A0A803W9W0|||http://purl.uniprot.org/uniprot/U3K9S7 ^@ Similarity ^@ Belongs to the heat shock protein 90 family. http://togogenome.org/gene/59894:DOPEY2 ^@ http://purl.uniprot.org/uniprot/U3K758 ^@ Similarity ^@ Belongs to the dopey family. http://togogenome.org/gene/59894:SLC8A1 ^@ http://purl.uniprot.org/uniprot/U3JI20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SPARCL1 ^@ http://purl.uniprot.org/uniprot/U3JR65 ^@ Similarity ^@ Belongs to the SPARC family. http://togogenome.org/gene/59894:SGSH ^@ http://purl.uniprot.org/uniprot/A0A803WFX2 ^@ PTM|||Similarity ^@ Belongs to the sulfatase family.|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:RPS6KA6 ^@ http://purl.uniprot.org/uniprot/U3JN67 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59894:RBM22 ^@ http://purl.uniprot.org/uniprot/U3K049 ^@ Similarity ^@ Belongs to the SLT11 family. http://togogenome.org/gene/59894:UNC5A ^@ http://purl.uniprot.org/uniprot/U3K1V8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the unc-5 family.|||Cell membrane|||Membrane|||Receptor for netrin required for axon guidance. Mediates axon repulsion of neuronal growth cones in the developing nervous system upon ligand binding. http://togogenome.org/gene/59894:HDHD2 ^@ http://purl.uniprot.org/uniprot/U3K2R3 ^@ Similarity ^@ Belongs to the HAD-like hydrolase superfamily. http://togogenome.org/gene/59894:KIF16B ^@ http://purl.uniprot.org/uniprot/A0A803VDS7|||http://purl.uniprot.org/uniprot/A0A803VSD9|||http://purl.uniprot.org/uniprot/A0A803W4G4|||http://purl.uniprot.org/uniprot/U3K8J2 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:SDHA ^@ http://purl.uniprot.org/uniprot/U3JHG6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAD-dependent oxidoreductase 2 family. FRD/SDH subfamily.|||Flavoprotein (FP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q).|||Mitochondrion inner membrane http://togogenome.org/gene/59894:TMEM9 ^@ http://purl.uniprot.org/uniprot/U3JIJ0 ^@ Similarity ^@ Belongs to the TMEM9 family. http://togogenome.org/gene/59894:TMEM150C ^@ http://purl.uniprot.org/uniprot/A0A803VH62 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101819517 ^@ http://purl.uniprot.org/uniprot/U3K2I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urea transporter family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LRRC8A ^@ http://purl.uniprot.org/uniprot/U3JFD0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LRRC8 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:WDR82 ^@ http://purl.uniprot.org/uniprot/U3K2P4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SWD2 family.|||Nucleus http://togogenome.org/gene/59894:COLGALT2 ^@ http://purl.uniprot.org/uniprot/U3JKB9 ^@ Similarity ^@ Belongs to the glycosyltransferase 25 family. http://togogenome.org/gene/59894:STXBP3 ^@ http://purl.uniprot.org/uniprot/A0A803V376|||http://purl.uniprot.org/uniprot/U3JJ38 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/59894:TAAR1 ^@ http://purl.uniprot.org/uniprot/A0A803W1E0 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:ZCCHC11 ^@ http://purl.uniprot.org/uniprot/A0A803VP66|||http://purl.uniprot.org/uniprot/A0A803VQB9|||http://purl.uniprot.org/uniprot/A0A803VUM2|||http://purl.uniprot.org/uniprot/U3JST8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-B-like family.|||Cytoplasm http://togogenome.org/gene/59894:SLC4A4 ^@ http://purl.uniprot.org/uniprot/A0A803VZU9|||http://purl.uniprot.org/uniprot/U3K110 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anion exchanger (TC 2.A.31) family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101814732 ^@ http://purl.uniprot.org/uniprot/A0A803VKP9 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:UBE3A ^@ http://purl.uniprot.org/uniprot/A0A803VS17|||http://purl.uniprot.org/uniprot/U3JN35 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin-protein ligase which accepts ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and transfers it to its substrates.|||Nucleus http://togogenome.org/gene/59894:SLC43A2 ^@ http://purl.uniprot.org/uniprot/U3JVX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC43A transporter (TC 2.A.1.44) family.|||Membrane http://togogenome.org/gene/59894:LOC101809373 ^@ http://purl.uniprot.org/uniprot/A0A803VFE4 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:GLA ^@ http://purl.uniprot.org/uniprot/A0A803VJB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/59894:KCNK18 ^@ http://purl.uniprot.org/uniprot/U3JHN6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane http://togogenome.org/gene/59894:SCAMP4 ^@ http://purl.uniprot.org/uniprot/A0A803V4Y3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59894:UBE2H ^@ http://purl.uniprot.org/uniprot/A0A803WF16|||http://purl.uniprot.org/uniprot/U3JQY8 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:TYR ^@ http://purl.uniprot.org/uniprot/U3JZL4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosinase family.|||Melanosome membrane|||Membrane http://togogenome.org/gene/59894:IGF2BP2 ^@ http://purl.uniprot.org/uniprot/U3KFX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM IMP/VICKZ family.|||Cytoplasm http://togogenome.org/gene/59894:BCAT1 ^@ http://purl.uniprot.org/uniprot/A0A803V737|||http://purl.uniprot.org/uniprot/U3JIZ8 ^@ Similarity ^@ Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59894:PSD2 ^@ http://purl.uniprot.org/uniprot/U3K4A0 ^@ Subcellular Location Annotation ^@ ruffle membrane http://togogenome.org/gene/59894:SUSD5 ^@ http://purl.uniprot.org/uniprot/U3JRF4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TGIF1 ^@ http://purl.uniprot.org/uniprot/A0A803V8W7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:UTS2B ^@ http://purl.uniprot.org/uniprot/U3JXY9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the urotensin-2 family.|||Secreted http://togogenome.org/gene/59894:PGK1 ^@ http://purl.uniprot.org/uniprot/U3K8X2 ^@ Similarity|||Subunit ^@ Belongs to the phosphoglycerate kinase family.|||Monomer. http://togogenome.org/gene/59894:NOX3 ^@ http://purl.uniprot.org/uniprot/U3KDG6 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:NIPAL1 ^@ http://purl.uniprot.org/uniprot/A0A803VPS3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/59894:ALDH1A3 ^@ http://purl.uniprot.org/uniprot/U3K6Q3 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:LOC101807260 ^@ http://purl.uniprot.org/uniprot/U3JZI2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FMO family.|||Endoplasmic reticulum membrane|||Membrane|||Microsome membrane http://togogenome.org/gene/59894:ALDH1A2 ^@ http://purl.uniprot.org/uniprot/U3KCL4 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:LOC101815312 ^@ http://purl.uniprot.org/uniprot/U3JZN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:GCLM ^@ http://purl.uniprot.org/uniprot/U3JHY2 ^@ Similarity|||Subunit ^@ Belongs to the aldo/keto reductase family. Glutamate--cysteine ligase light chain subfamily.|||Heterodimer of a catalytic heavy chain and a regulatory light chain. http://togogenome.org/gene/59894:NEK7 ^@ http://purl.uniprot.org/uniprot/U3JJB6 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:HTR1F ^@ http://purl.uniprot.org/uniprot/U3KJS5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||G-protein coupled receptor for 5-hydroxytryptamine (serotonin). Also functions as a receptor for various alkaloids and psychoactive substances. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors, such as adenylate cyclase. Signaling inhibits adenylate cyclase activity.|||Membrane http://togogenome.org/gene/59894:MYOZ1 ^@ http://purl.uniprot.org/uniprot/U3JX94 ^@ Similarity ^@ Belongs to the myozenin family. http://togogenome.org/gene/59894:MAP3K9 ^@ http://purl.uniprot.org/uniprot/A0A803W787 ^@ Activity Regulation|||Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily.|||Homodimer.|||Homodimerization via the leucine zipper domains is required for autophosphorylation. http://togogenome.org/gene/59894:ADCYAP1 ^@ http://purl.uniprot.org/uniprot/A0A803WD84 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/59894:MPP5 ^@ http://purl.uniprot.org/uniprot/U3JRT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||tight junction http://togogenome.org/gene/59894:KCNG1 ^@ http://purl.uniprot.org/uniprot/U3KF05 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:GTF2E1 ^@ http://purl.uniprot.org/uniprot/U3JRU8 ^@ Function|||Similarity ^@ Belongs to the TFIIE alpha subunit family.|||Recruits TFIIH to the initiation complex and stimulates the RNA polymerase II C-terminal domain kinase and DNA-dependent ATPase activities of TFIIH. Both TFIIH and TFIIE are required for promoter clearance by RNA polymerase. http://togogenome.org/gene/59894:PSMC3 ^@ http://purl.uniprot.org/uniprot/U3JV66 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AAA ATPase family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:TGM4 ^@ http://purl.uniprot.org/uniprot/U3JIU2 ^@ Cofactor|||Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family.|||Binds 1 Ca(2+) ion per subunit. http://togogenome.org/gene/59894:RAD54L2 ^@ http://purl.uniprot.org/uniprot/U3K2S1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNF2/RAD54 helicase family.|||Nucleus http://togogenome.org/gene/59894:LPGAT1 ^@ http://purl.uniprot.org/uniprot/U3KDB0 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:EYA1 ^@ http://purl.uniprot.org/uniprot/A0A803VGU5|||http://purl.uniprot.org/uniprot/A0A803VNE3 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/59894:MCTP2 ^@ http://purl.uniprot.org/uniprot/U3K705 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DPAGT1 ^@ http://purl.uniprot.org/uniprot/U3K5C0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 4 family.|||Catalyzes the initial step of dolichol-linked oligosaccharide biosynthesis in N-linked protein glycosylation pathway: transfers GlcNAc-1-P from UDP-GlcNAc onto the carrier lipid dolichyl phosphate (P-dolichol), yielding GlcNAc-P-P-dolichol.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:JPH1 ^@ http://purl.uniprot.org/uniprot/U3K1M3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the junctophilin family.|||Cell membrane|||Endoplasmic reticulum membrane|||Junctophilins contribute to the formation of junctional membrane complexes (JMCs) which link the plasma membrane with the endoplasmic or sarcoplasmic reticulum in excitable cells. Provides a structural foundation for functional cross-talk between the cell surface and intracellular calcium release channels.|||Membrane http://togogenome.org/gene/59894:SEMA3D ^@ http://purl.uniprot.org/uniprot/U3K7V5 ^@ Caution|||Similarity ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:SNAP47 ^@ http://purl.uniprot.org/uniprot/U3JEE0 ^@ Similarity ^@ Belongs to the SVAP1 family. http://togogenome.org/gene/59894:ADCK1 ^@ http://purl.uniprot.org/uniprot/U3KDL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. ADCK protein kinase family.|||Secreted http://togogenome.org/gene/59894:MFSD8 ^@ http://purl.uniprot.org/uniprot/U3K0B1 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:AK5 ^@ http://purl.uniprot.org/uniprot/U3JT41 ^@ Similarity ^@ Belongs to the adenylate kinase family. http://togogenome.org/gene/59894:CHAF1A ^@ http://purl.uniprot.org/uniprot/U3JEF1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CHAF1A family.|||Nucleus http://togogenome.org/gene/59894:UTP3 ^@ http://purl.uniprot.org/uniprot/U3KJH1 ^@ Similarity ^@ Belongs to the SAS10 family. http://togogenome.org/gene/59894:STARD13 ^@ http://purl.uniprot.org/uniprot/A0A803V5V3|||http://purl.uniprot.org/uniprot/A0A803VM20|||http://purl.uniprot.org/uniprot/U3K148 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:SLC37A3 ^@ http://purl.uniprot.org/uniprot/U3JM54 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Organophosphate:Pi antiporter (OPA) (TC 2.A.1.4) family.|||Membrane http://togogenome.org/gene/59894:GSG1 ^@ http://purl.uniprot.org/uniprot/U3KAA8 ^@ Similarity ^@ Belongs to the FAM234 family. http://togogenome.org/gene/59894:NPFFR1 ^@ http://purl.uniprot.org/uniprot/U3KDS4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for NPAF (A-18-F-amide) and NPFF (F-8-F-amide) neuropeptides, also known as morphine-modulating peptides. Can also be activated by a variety of naturally occurring or synthetic FMRF-amide like ligands. This receptor mediates its action by association with G proteins that activate a phosphatidylinositol-calcium second messenger system. http://togogenome.org/gene/59894:UPF2 ^@ http://purl.uniprot.org/uniprot/A0A803VBX0 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:TSPAN14 ^@ http://purl.uniprot.org/uniprot/A0A803V3C7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:ALOX5 ^@ http://purl.uniprot.org/uniprot/U3JY58 ^@ Caution|||Similarity ^@ Belongs to the lipoxygenase family.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:CAB39 ^@ http://purl.uniprot.org/uniprot/A0A803VN76 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/59894:SEC11A ^@ http://purl.uniprot.org/uniprot/U3K5N4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase S26B family.|||Component of the signal peptidase complex.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LOC101810444 ^@ http://purl.uniprot.org/uniprot/U3K834 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NELF-D family.|||Nucleus http://togogenome.org/gene/59894:POLR3A ^@ http://purl.uniprot.org/uniprot/U3JWS9 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the RNA polymerase beta' chain family.|||Component of the RNA polymerase III (Pol III) complex consisting of 17 subunits.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates.|||Nucleus http://togogenome.org/gene/59894:CCSER2 ^@ http://purl.uniprot.org/uniprot/A0A803VV53|||http://purl.uniprot.org/uniprot/A0A803VVB5 ^@ Similarity ^@ Belongs to the CCSER family. http://togogenome.org/gene/59894:HACD4 ^@ http://purl.uniprot.org/uniprot/A0A803VK08 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:SOAT1 ^@ http://purl.uniprot.org/uniprot/U3K0G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the membrane-bound acyltransferase family. Sterol o-acyltransferase subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:NIF3L1 ^@ http://purl.uniprot.org/uniprot/A0A803VTK6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GTP cyclohydrolase I type 2/NIF3 family.|||Cytoplasm|||Homodimer. Interacts with COPS2. Interacts with THOC7.|||May function as a transcriptional corepressor through its interaction with COPS2, negatively regulating the expression of genes involved in neuronal differentiation.|||Nucleus http://togogenome.org/gene/59894:FLT4 ^@ http://purl.uniprot.org/uniprot/U3JZJ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane|||Nucleus http://togogenome.org/gene/59894:ANKRD34C ^@ http://purl.uniprot.org/uniprot/U3K8Y6 ^@ Similarity ^@ Belongs to the ANKRD34 family. http://togogenome.org/gene/59894:EBAG9 ^@ http://purl.uniprot.org/uniprot/A0A803VGI5 ^@ Function|||Subcellular Location Annotation ^@ Golgi apparatus membrane|||May participate in suppression of cell proliferation and induces apoptotic cell death through activation of interleukin-1-beta converting enzyme (ICE)-like proteases. http://togogenome.org/gene/59894:LOC101812721 ^@ http://purl.uniprot.org/uniprot/U3KH05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/59894:FSIP1 ^@ http://purl.uniprot.org/uniprot/A0A803V8E8|||http://purl.uniprot.org/uniprot/U3JS54 ^@ Similarity ^@ Belongs to the FSIP1 family. http://togogenome.org/gene/59894:CNOT11 ^@ http://purl.uniprot.org/uniprot/U3JMG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CNOT11 family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:LOC101811789 ^@ http://purl.uniprot.org/uniprot/A0A803VY64 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:AP1G1 ^@ http://purl.uniprot.org/uniprot/A0A803V0M9|||http://purl.uniprot.org/uniprot/U3JIW1 ^@ Similarity ^@ Belongs to the adaptor complexes large subunit family. http://togogenome.org/gene/59894:HIBCH ^@ http://purl.uniprot.org/uniprot/U3JP69 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the enoyl-CoA hydratase/isomerase family.|||Hydrolyzes 3-hydroxyisobutyryl-CoA (HIBYL-CoA), a saline catabolite. Has high activity toward isobutyryl-CoA. Could be an isobutyryl-CoA dehydrogenase that functions in valine catabolism. Also hydrolyzes 3-hydroxypropanoyl-CoA.|||Mitochondrion http://togogenome.org/gene/59894:MAATS1 ^@ http://purl.uniprot.org/uniprot/U3JS41 ^@ Similarity ^@ Belongs to the CFAP91 family. http://togogenome.org/gene/59894:KCNMB2 ^@ http://purl.uniprot.org/uniprot/A0A803V6B3|||http://purl.uniprot.org/uniprot/U3K165 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CCL20 ^@ http://purl.uniprot.org/uniprot/U3JWT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/59894:LOC101815857 ^@ http://purl.uniprot.org/uniprot/U3JY75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/59894:PRPSAP1 ^@ http://purl.uniprot.org/uniprot/U3JDY7 ^@ Similarity ^@ Belongs to the ribose-phosphate pyrophosphokinase family. http://togogenome.org/gene/59894:LOC101817209 ^@ http://purl.uniprot.org/uniprot/U3JGH2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0389 family.|||Membrane http://togogenome.org/gene/59894:FAM72A ^@ http://purl.uniprot.org/uniprot/U3JCT8 ^@ Similarity ^@ Belongs to the FAM72 family. http://togogenome.org/gene/59894:UBE2R2 ^@ http://purl.uniprot.org/uniprot/A0A803VZ21 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:RER1 ^@ http://purl.uniprot.org/uniprot/A0A803V3T1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RER1 family.|||Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment.|||Membrane http://togogenome.org/gene/59894:AQP11 ^@ http://purl.uniprot.org/uniprot/U3JYS5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family. AQP11/AQP12 subfamily.|||Membrane http://togogenome.org/gene/59894:JAGN1 ^@ http://purl.uniprot.org/uniprot/U3KEU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the jagunal family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:CENPH ^@ http://purl.uniprot.org/uniprot/U3K5I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CENP-H/MCM16 family.|||Nucleus|||kinetochore http://togogenome.org/gene/59894:LOC101819725 ^@ http://purl.uniprot.org/uniprot/A0A803W5D6 ^@ Similarity ^@ Belongs to the histone H2B family. http://togogenome.org/gene/59894:FOXJ1 ^@ http://purl.uniprot.org/uniprot/U3JE04 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101816626 ^@ http://purl.uniprot.org/uniprot/A0A803V5Q4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 56 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:KCNJ15 ^@ http://purl.uniprot.org/uniprot/A0A803VE08 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59894:PEX12 ^@ http://purl.uniprot.org/uniprot/U3K530 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pex2/pex10/pex12 family.|||Peroxisome membrane|||Required for protein import into peroxisomes. http://togogenome.org/gene/59894:PRPF38A ^@ http://purl.uniprot.org/uniprot/U3JST2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the PRP38 family.|||Component of the spliceosome B complex.|||Involved in pre-mRNA splicing as a component of the spliceosome.|||Nucleus http://togogenome.org/gene/59894:CDS1 ^@ http://purl.uniprot.org/uniprot/U3JS21 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CDS family.|||Catalyzes the conversion of phosphatidic acid (PA) to CDP-diacylglycerol (CDP-DAG), an essential intermediate in the synthesis of phosphatidylglycerol, cardiolipin and phosphatidylinositol.|||Membrane http://togogenome.org/gene/59894:YWHAZ ^@ http://purl.uniprot.org/uniprot/U3JTK2 ^@ Similarity ^@ Belongs to the 14-3-3 family. http://togogenome.org/gene/59894:SGO1 ^@ http://purl.uniprot.org/uniprot/U3K3K9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shugoshin family.|||centromere http://togogenome.org/gene/59894:GADL1 ^@ http://purl.uniprot.org/uniprot/U3K3E9 ^@ Similarity|||Subunit ^@ Belongs to the group II decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:AGL ^@ http://purl.uniprot.org/uniprot/A0A803VW93|||http://purl.uniprot.org/uniprot/U3JI98 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycogen debranching enzyme family.|||Cytoplasm|||Multifunctional enzyme acting as 1,4-alpha-D-glucan:1,4-alpha-D-glucan 4-alpha-D-glycosyltransferase and amylo-1,6-glucosidase in glycogen degradation. http://togogenome.org/gene/59894:LOC101809996 ^@ http://purl.uniprot.org/uniprot/U3JNA0 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:COPG2 ^@ http://purl.uniprot.org/uniprot/U3JRF1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COPG family.|||COPI-coated vesicle membrane|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Oligomeric complex.|||The coatomer is a cytosolic protein complex that binds to dilysine motifs and reversibly associates with Golgi non-clathrin-coated vesicles, which further mediate biosynthetic protein transport from the ER, via the Golgi up to the trans Golgi network. Coatomer complex is required for budding from Golgi membranes, and is essential for the retrograde Golgi-to-ER transport of dilysine-tagged proteins. http://togogenome.org/gene/59894:CRYBA4 ^@ http://purl.uniprot.org/uniprot/U3K1B5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/59894:CEP57 ^@ http://purl.uniprot.org/uniprot/U3JC40 ^@ Similarity ^@ Belongs to the translokin family. http://togogenome.org/gene/59894:FAM83G ^@ http://purl.uniprot.org/uniprot/A0A803VRS3 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/59894:CUL5 ^@ http://purl.uniprot.org/uniprot/A0A803W4G6 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59894:QRSL1 ^@ http://purl.uniprot.org/uniprot/U3KAY7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Allows the formation of correctly charged Gln-tRNA(Gln) through the transamidation of misacylated Glu-tRNA(Gln) in the mitochondria. The reaction takes place in the presence of glutamine and ATP through an activated gamma-phospho-Glu-tRNA(Gln).|||Belongs to the amidase family. GatA subfamily.|||Mitochondrion|||Subunit of the heterotrimeric GatCAB amidotransferase (AdT) complex, composed of A (QRSL1), B (GATB) and C (GATC) subunits. http://togogenome.org/gene/59894:LOC101813950 ^@ http://purl.uniprot.org/uniprot/U3JR15 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:PKIA ^@ http://purl.uniprot.org/uniprot/U3K1Q6 ^@ Function|||Similarity ^@ Belongs to the PKI family.|||Extremely potent competitive inhibitor of cAMP-dependent protein kinase activity, this protein interacts with the catalytic subunit of the enzyme after the cAMP-induced dissociation of its regulatory chains. http://togogenome.org/gene/59894:MCM10 ^@ http://purl.uniprot.org/uniprot/U3JGS7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MCM10 family.|||Nucleus http://togogenome.org/gene/59894:POLR1B ^@ http://purl.uniprot.org/uniprot/U3JD88 ^@ Function|||Similarity ^@ Belongs to the RNA polymerase beta chain family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Second largest core component of RNA polymerase I which synthesizes ribosomal RNA precursors. Proposed to contribute to the polymerase catalytic activity and forms the polymerase active center together with the largest subunit. Pol I is composed of mobile elements and RPA2 is part of the core element with the central large cleft and probably a clamp element that moves to open and close the cleft. http://togogenome.org/gene/59894:ZRANB2 ^@ http://purl.uniprot.org/uniprot/U3JET7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZRANB2 family.|||May interfere with constitutive 5'-splice site selection.|||Nucleus http://togogenome.org/gene/59894:GORASP1 ^@ http://purl.uniprot.org/uniprot/A0A803V3T7 ^@ Similarity ^@ Belongs to the GORASP family. http://togogenome.org/gene/59894:GRK7 ^@ http://purl.uniprot.org/uniprot/U3JWY3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/59894:GBF1 ^@ http://purl.uniprot.org/uniprot/A0A803W840|||http://purl.uniprot.org/uniprot/U3JXR2 ^@ Subcellular Location Annotation ^@ Golgi apparatus http://togogenome.org/gene/59894:ABL2 ^@ http://purl.uniprot.org/uniprot/A0A803VWJ5|||http://purl.uniprot.org/uniprot/U3K0H4 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:KCNK9 ^@ http://purl.uniprot.org/uniprot/A0A803V4V9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the two pore domain potassium channel (TC 1.A.1.8) family.|||Membrane|||pH-dependent, voltage-insensitive, background potassium channel protein. http://togogenome.org/gene/59894:HTR1E ^@ http://purl.uniprot.org/uniprot/U3KJX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:STX1A ^@ http://purl.uniprot.org/uniprot/U3JXC1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the syntaxin family.|||Membrane http://togogenome.org/gene/59894:DLK2 ^@ http://purl.uniprot.org/uniprot/A0A803VRI4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:NDUFB3 ^@ http://purl.uniprot.org/uniprot/U3JNF9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFB3 subunit family.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:RPS6KB1 ^@ http://purl.uniprot.org/uniprot/U3JSM2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59894:NPRL3 ^@ http://purl.uniprot.org/uniprot/A0A803V4W6|||http://purl.uniprot.org/uniprot/A0A803W6J2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ As a component of the GATOR1 complex functions as an inhibitor of the amino acid-sensing branch of the TORC1 pathway.|||Belongs to the NPR3 family.|||Lysosome http://togogenome.org/gene/59894:PPFIA2 ^@ http://purl.uniprot.org/uniprot/U3K7H1 ^@ Similarity ^@ Belongs to the liprin family. Liprin-alpha subfamily. http://togogenome.org/gene/59894:RHCG ^@ http://purl.uniprot.org/uniprot/U3K7G7|||http://purl.uniprot.org/uniprot/U3K7G8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/59894:FGFBP2 ^@ http://purl.uniprot.org/uniprot/U3KJU7 ^@ Similarity ^@ Belongs to the fibroblast growth factor-binding protein family. http://togogenome.org/gene/59894:MANBAL ^@ http://purl.uniprot.org/uniprot/U3JSM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UPF0239 family.|||Membrane http://togogenome.org/gene/59894:RPL34 ^@ http://purl.uniprot.org/uniprot/U3KCM4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL34 family. http://togogenome.org/gene/59894:BORCS5 ^@ http://purl.uniprot.org/uniprot/U3JIV2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BORCS5 family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:C6 ^@ http://purl.uniprot.org/uniprot/U3JH04 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:GABBR2 ^@ http://purl.uniprot.org/uniprot/U3JRI5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family. GABA-B receptor subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:MTNR1B ^@ http://purl.uniprot.org/uniprot/U3JBY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:MAT1A ^@ http://purl.uniprot.org/uniprot/U3JWK3 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/59894:LOC101806175 ^@ http://purl.uniprot.org/uniprot/U3JM47 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:PRPF19 ^@ http://purl.uniprot.org/uniprot/U3KC60 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat PRP19 family.|||Homotetramer.|||Lipid droplet|||Ubiquitin-protein ligase which is mainly involved pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome.|||nucleoplasm http://togogenome.org/gene/59894:PDP1 ^@ http://purl.uniprot.org/uniprot/A0A803UZX3 ^@ Similarity ^@ Belongs to the PP2C family. http://togogenome.org/gene/59894:NEURL2 ^@ http://purl.uniprot.org/uniprot/U3JPR4 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:AMIGO3 ^@ http://purl.uniprot.org/uniprot/U3KIW1 ^@ Similarity ^@ Belongs to the immunoglobulin superfamily. AMIGO family. http://togogenome.org/gene/59894:CCDC47 ^@ http://purl.uniprot.org/uniprot/U3JQ08 ^@ Subcellular Location Annotation ^@ Membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/59894:APOPT1 ^@ http://purl.uniprot.org/uniprot/U3JJN1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COA8 family.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:FAM118B ^@ http://purl.uniprot.org/uniprot/U3JR35 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM118 family.|||Cajal body|||May play a role in Cajal bodies formation. http://togogenome.org/gene/59894:KIF20B ^@ http://purl.uniprot.org/uniprot/U3JZ31 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:FAM63B ^@ http://purl.uniprot.org/uniprot/U3KCQ5 ^@ Function|||Similarity ^@ Belongs to the MINDY deubiquitinase family. FAM63 subfamily.|||Hydrolase that can specifically remove 'Lys-48'-linked conjugated ubiquitin from proteins. Has exodeubiquitinase activity and has a preference for long polyubiquitin chains. May play a regulatory role at the level of protein turnover. http://togogenome.org/gene/59894:ENPEP ^@ http://purl.uniprot.org/uniprot/U3JVG0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase M1 family.|||Binds 1 zinc ion per subunit.|||Cell membrane|||Homodimer; disulfide-linked. http://togogenome.org/gene/59894:GRM1 ^@ http://purl.uniprot.org/uniprot/U3KF58|||http://purl.uniprot.org/uniprot/U3KF60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:TOP2A ^@ http://purl.uniprot.org/uniprot/U3JC95 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type II topoisomerase family.|||Homodimer.|||Key decatenating enzyme that alters DNA topology by binding to two double-stranded DNA molecules, generating a double-stranded break in one of the strands, passing the intact strand through the broken strand, and religating the broken strand.|||nucleolus|||nucleoplasm http://togogenome.org/gene/59894:PTPN4 ^@ http://purl.uniprot.org/uniprot/A0A803VT29|||http://purl.uniprot.org/uniprot/U3KFH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/59894:CHST12 ^@ http://purl.uniprot.org/uniprot/A0A803WF73 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sulfotransferase 2 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:LOC101808955 ^@ http://purl.uniprot.org/uniprot/U3JNE2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ABAT ^@ http://purl.uniprot.org/uniprot/U3JN19 ^@ Similarity|||Subunit ^@ Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family.|||Homodimer; disulfide-linked. http://togogenome.org/gene/59894:LOC101807214 ^@ http://purl.uniprot.org/uniprot/U3KDS6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:GUK1 ^@ http://purl.uniprot.org/uniprot/U3JEB5 ^@ Similarity ^@ Belongs to the guanylate kinase family. http://togogenome.org/gene/59894:LOC101820513 ^@ http://purl.uniprot.org/uniprot/A0A803VCA6|||http://purl.uniprot.org/uniprot/U3K090 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59894:MSH5 ^@ http://purl.uniprot.org/uniprot/U3KLN3 ^@ Similarity ^@ Belongs to the DNA mismatch repair MutS family. http://togogenome.org/gene/59894:LGALS3 ^@ http://purl.uniprot.org/uniprot/A0A803V3F9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus|||Secreted http://togogenome.org/gene/59894:THNSL2 ^@ http://purl.uniprot.org/uniprot/U3K6H6 ^@ Similarity ^@ Belongs to the threonine synthase family. http://togogenome.org/gene/59894:HRH2 ^@ http://purl.uniprot.org/uniprot/U3K1I7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:RBP1 ^@ http://purl.uniprot.org/uniprot/U3JNC4 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:PSMF1 ^@ http://purl.uniprot.org/uniprot/U3JTA5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the proteasome inhibitor PI31 family.|||Cytoplasm|||Endoplasmic reticulum|||Plays an important role in control of proteasome function. Inhibits the hydrolysis of protein and peptide substrates by the 20S proteasome. Also inhibits the activation of the proteasome by the proteasome regulatory proteins PA700 and PA28. http://togogenome.org/gene/59894:TPST2 ^@ http://purl.uniprot.org/uniprot/U3K1C4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein sulfotransferase family.|||Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.|||Golgi apparatus membrane http://togogenome.org/gene/59894:PCBP2 ^@ http://purl.uniprot.org/uniprot/U3JJZ9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:SMARCAD1 ^@ http://purl.uniprot.org/uniprot/A0A803VDR8|||http://purl.uniprot.org/uniprot/U3JU94 ^@ Subcellular Location Annotation ^@ Chromosome http://togogenome.org/gene/59894:RNF13 ^@ http://purl.uniprot.org/uniprot/A0A803VC81 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:AFF2 ^@ http://purl.uniprot.org/uniprot/U3KC71 ^@ Similarity ^@ Belongs to the AF4 family. http://togogenome.org/gene/59894:LOC101810686 ^@ http://purl.uniprot.org/uniprot/U3K0X3 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:C1HXorf23 ^@ http://purl.uniprot.org/uniprot/U3JNN7 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/59894:SPSB3 ^@ http://purl.uniprot.org/uniprot/A0A803V021 ^@ Function|||Similarity ^@ Belongs to the SPSB family.|||May be a substrate recognition component of a SCF-like ECS (Elongin BC-CUL2/5-SOCS-box protein) E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/59894:LOC101818184 ^@ http://purl.uniprot.org/uniprot/U3KKK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITPRIP family.|||Membrane http://togogenome.org/gene/59894:KLHL36 ^@ http://purl.uniprot.org/uniprot/A0A803VEB2 ^@ Function ^@ Probable substrate-specific adapter of an E3 ubiquitin-protein ligase complex which mediates the ubiquitination and subsequent proteasomal degradation of target proteins. http://togogenome.org/gene/59894:IL1RL1 ^@ http://purl.uniprot.org/uniprot/U3JM51 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the interleukin-1 receptor family.|||axon|||dendrite http://togogenome.org/gene/59894:CP ^@ http://purl.uniprot.org/uniprot/A0A803VYE2|||http://purl.uniprot.org/uniprot/U3JRZ7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/59894:HMGN5 ^@ http://purl.uniprot.org/uniprot/U3JN83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMGN family.|||Nucleus http://togogenome.org/gene/59894:TCP11L2 ^@ http://purl.uniprot.org/uniprot/U3KG59 ^@ Similarity ^@ Belongs to the TCP11 family. http://togogenome.org/gene/59894:CHDH ^@ http://purl.uniprot.org/uniprot/U3K1Q0 ^@ Similarity ^@ Belongs to the GMC oxidoreductase family. http://togogenome.org/gene/59894:PDE5A ^@ http://purl.uniprot.org/uniprot/U3JDP9 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:MPPED2 ^@ http://purl.uniprot.org/uniprot/U3KCK9 ^@ Similarity ^@ Belongs to the UPF0046 family. http://togogenome.org/gene/59894:MSN ^@ http://purl.uniprot.org/uniprot/U3JNV4 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/59894:EML4 ^@ http://purl.uniprot.org/uniprot/U3KDR8 ^@ Similarity ^@ Belongs to the WD repeat EMAP family. http://togogenome.org/gene/59894:SLC16A1 ^@ http://purl.uniprot.org/uniprot/A0A803VY03 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Cell membrane|||Membrane|||Proton-coupled monocarboxylate transporter. Catalyzes the rapid transport across the plasma membrane of many monocarboxylates such as lactate, pyruvate, branched-chain oxo acids derived from leucine, valine and isoleucine, and the ketone bodies acetoacetate, beta-hydroxybutyrate and acetate. Depending on the tissue and on cicumstances, mediates the import or export of lactic acid and ketone bodies. Required for normal nutrient assimilation, increase of white adipose tissue and body weight gain when on a high-fat diet. Plays a role in cellular responses to a high-fat diet by modulating the cellular levels of lactate and pyruvate, small molecules that contribute to the regulation of central metabolic pathways and insulin secretion, with concomitant effects on plasma insulin levels and blood glucose homeostasis. http://togogenome.org/gene/59894:LOC101810165 ^@ http://purl.uniprot.org/uniprot/U3KEY0 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:TMEM14A ^@ http://purl.uniprot.org/uniprot/U3JGQ0 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/59894:TDP1 ^@ http://purl.uniprot.org/uniprot/A0A803V0U3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tyrosyl-DNA phosphodiesterase family.|||Nucleus http://togogenome.org/gene/59894:OGT ^@ http://purl.uniprot.org/uniprot/U3KB11 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 41 family. O-GlcNAc transferase subfamily.|||Cell projection|||Mitochondrion membrane http://togogenome.org/gene/59894:NR5A2 ^@ http://purl.uniprot.org/uniprot/A0A803WA21 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR5 subfamily.|||Nucleus http://togogenome.org/gene/59894:ZNF622 ^@ http://purl.uniprot.org/uniprot/U3JYH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the REI1 family.|||Cytoplasm http://togogenome.org/gene/59894:ADCY5 ^@ http://purl.uniprot.org/uniprot/U3KFY5 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59894:MARK3 ^@ http://purl.uniprot.org/uniprot/U3JJK1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. SNF1 subfamily.|||dendrite http://togogenome.org/gene/59894:CCK ^@ http://purl.uniprot.org/uniprot/U3KCS4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the gastrin/cholecystokinin family.|||Secreted http://togogenome.org/gene/59894:HLCS ^@ http://purl.uniprot.org/uniprot/U3JRP5 ^@ Similarity ^@ Belongs to the biotin--protein ligase family. http://togogenome.org/gene/59894:PVALB ^@ http://purl.uniprot.org/uniprot/A0A803W413 ^@ Function|||Similarity ^@ Belongs to the parvalbumin family.|||In muscle, parvalbumin is thought to be involved in relaxation after contraction. It binds two calcium ions. http://togogenome.org/gene/59894:OSBPL5 ^@ http://purl.uniprot.org/uniprot/A0A803W7S0 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:PLCB4 ^@ http://purl.uniprot.org/uniprot/A0A803W169|||http://purl.uniprot.org/uniprot/U3K9D5 ^@ Function ^@ The production of the second messenger molecules diacylglycerol (DAG) and inositol 1,4,5-trisphosphate (IP3) is mediated by activated phosphatidylinositol-specific phospholipase C enzymes. http://togogenome.org/gene/59894:CRY1 ^@ http://purl.uniprot.org/uniprot/U3KG30 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/59894:LOC101817111 ^@ http://purl.uniprot.org/uniprot/U3K5X8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:ATXN1 ^@ http://purl.uniprot.org/uniprot/U3KG31 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATXN1 family.|||Nucleus http://togogenome.org/gene/59894:BCL2 ^@ http://purl.uniprot.org/uniprot/A0A803VR88 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Bcl-2 family.|||Cytoplasm|||Endoplasmic reticulum membrane|||Membrane|||Mitochondrion outer membrane|||Nucleus membrane http://togogenome.org/gene/59894:LYAR ^@ http://purl.uniprot.org/uniprot/U3K461 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:GINS2 ^@ http://purl.uniprot.org/uniprot/A0A803VE78 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GINS2/PSF2 family.|||Chromosome|||Component of the GINS complex.|||Nucleus http://togogenome.org/gene/59894:GOLT1B ^@ http://purl.uniprot.org/uniprot/U3JIZ5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/59894:TCTN1 ^@ http://purl.uniprot.org/uniprot/U3K333 ^@ Similarity|||Subunit ^@ Belongs to the tectonic family.|||Part of the tectonic-like complex (also named B9 complex). http://togogenome.org/gene/59894:PODXL2 ^@ http://purl.uniprot.org/uniprot/U3JZJ5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101809697 ^@ http://purl.uniprot.org/uniprot/U3K5A5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the intercrine beta (chemokine CC) family.|||Secreted http://togogenome.org/gene/59894:ZC3H14 ^@ http://purl.uniprot.org/uniprot/A0A803V317 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZC3H14 family.|||Involved in poly(A) tail length control in neuronal cells. Binds the polyadenosine RNA oligonucleotides.|||Nucleus speckle http://togogenome.org/gene/59894:C11H16orf87 ^@ http://purl.uniprot.org/uniprot/U3JBK2 ^@ Similarity ^@ Belongs to the UPF0547 family. http://togogenome.org/gene/59894:SLC39A13 ^@ http://purl.uniprot.org/uniprot/U3JV63 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101813067 ^@ http://purl.uniprot.org/uniprot/U3KFF5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:TIMM10 ^@ http://purl.uniprot.org/uniprot/U3K9H0 ^@ Function ^@ Mitochondrial intermembrane chaperone that participates in the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane. May also be required for the transfer of beta-barrel precursors from the TOM complex to the sorting and assembly machinery (SAM complex) of the outer membrane. Acts as a chaperone-like protein that protects the hydrophobic precursors from aggregation and guide them through the mitochondrial intermembrane space. http://togogenome.org/gene/59894:LDLRAD4 ^@ http://purl.uniprot.org/uniprot/A0A803V8Y5|||http://purl.uniprot.org/uniprot/A0A803VUP0|||http://purl.uniprot.org/uniprot/A0A803WCV2|||http://purl.uniprot.org/uniprot/U3JVF5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PMEPA1 family.|||Early endosome membrane|||Endosome membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:NFX1 ^@ http://purl.uniprot.org/uniprot/U3KFD1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NFX1 family.|||Nucleus http://togogenome.org/gene/59894:FASN ^@ http://purl.uniprot.org/uniprot/U3KB05 ^@ Function ^@ Fatty acid synthetase is a multifunctional enzyme that catalyzes the de novo biosynthesis of long-chain saturated fatty acids starting from acetyl-CoA and malonyl-CoA in the presence of NADPH. This multifunctional protein contains 7 catalytic activities and a site for the binding of the prosthetic group 4'-phosphopantetheine of the acyl carrier protein ([ACP]) domain. http://togogenome.org/gene/59894:ATP2A2 ^@ http://purl.uniprot.org/uniprot/A0A803W5X9 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/59894:MOS ^@ http://purl.uniprot.org/uniprot/U3KK77 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:SURF6 ^@ http://purl.uniprot.org/uniprot/U3JFK2 ^@ Similarity ^@ Belongs to the SURF6 family. http://togogenome.org/gene/59894:GSKIP ^@ http://purl.uniprot.org/uniprot/U3JIP0 ^@ Similarity ^@ Belongs to the GSKIP family. http://togogenome.org/gene/59894:RPL32 ^@ http://purl.uniprot.org/uniprot/U3KGV4 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL32 family. http://togogenome.org/gene/59894:FAM173B ^@ http://purl.uniprot.org/uniprot/U3JZG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANT/ATPSC lysine N-methyltransferase family.|||Mitochondrion membrane http://togogenome.org/gene/59894:LOC101817609 ^@ http://purl.uniprot.org/uniprot/U3KH72 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/59894:DSE ^@ http://purl.uniprot.org/uniprot/U3K8X7 ^@ Similarity ^@ Belongs to the dermatan-sulfate isomerase family. http://togogenome.org/gene/59894:SYN3 ^@ http://purl.uniprot.org/uniprot/U3KFP8 ^@ Similarity ^@ Belongs to the synapsin family. http://togogenome.org/gene/59894:TSPAN5 ^@ http://purl.uniprot.org/uniprot/U3JUJ7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:SCAMP1 ^@ http://purl.uniprot.org/uniprot/U3K5W1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SCAMP family.|||Membrane http://togogenome.org/gene/59894:KIF2C ^@ http://purl.uniprot.org/uniprot/U3JRM5 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:EEF1A2 ^@ http://purl.uniprot.org/uniprot/U3K725 ^@ Function|||Similarity ^@ Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. EF-Tu/EF-1A subfamily.|||This protein promotes the GTP-dependent binding of aminoacyl-tRNA to the A-site of ribosomes during protein biosynthesis. http://togogenome.org/gene/59894:SLC2A2 ^@ http://purl.uniprot.org/uniprot/U3K1M7 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:CAB39L ^@ http://purl.uniprot.org/uniprot/U3K122 ^@ Function|||Similarity|||Subunit ^@ Belongs to the Mo25 family.|||Component of a complex that binds and activates STK11/LKB1. In the complex, required to stabilize the interaction between CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta) and STK11/LKB1.|||Component of a trimeric complex composed of STK11/LKB1, STRAD (STRADA or STRADB) and CAB39/MO25 (CAB39/MO25alpha or CAB39L/MO25beta): the complex tethers STK11/LKB1 in the cytoplasm and stimulates its catalytic activity. http://togogenome.org/gene/59894:FAM198B ^@ http://purl.uniprot.org/uniprot/A0A803VHW4 ^@ Similarity ^@ Belongs to the GASK family. http://togogenome.org/gene/59894:TTC39C ^@ http://purl.uniprot.org/uniprot/U3JU90 ^@ Similarity ^@ Belongs to the TTC39 family. http://togogenome.org/gene/59894:AGRP ^@ http://purl.uniprot.org/uniprot/U3JXU1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:ANKZF1 ^@ http://purl.uniprot.org/uniprot/A0A803VPN4|||http://purl.uniprot.org/uniprot/U3JNQ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ANKZF1/VMS1 family.|||Cytoplasm http://togogenome.org/gene/59894:EPN2 ^@ http://purl.uniprot.org/uniprot/A0A803V4L4|||http://purl.uniprot.org/uniprot/A0A803VRW7 ^@ Similarity ^@ Belongs to the epsin family. http://togogenome.org/gene/59894:DCSTAMP ^@ http://purl.uniprot.org/uniprot/A0A803VCR3|||http://purl.uniprot.org/uniprot/U3JU35 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:TSPAN4 ^@ http://purl.uniprot.org/uniprot/A0A803W7K7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tetraspanin (TM4SF) family.|||Membrane http://togogenome.org/gene/59894:PPARGC1A ^@ http://purl.uniprot.org/uniprot/A0A803VFB1 ^@ Subcellular Location Annotation ^@ PML body http://togogenome.org/gene/59894:AGPAT3 ^@ http://purl.uniprot.org/uniprot/A0A803VJ41 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:RTCA ^@ http://purl.uniprot.org/uniprot/U3JID7 ^@ Function|||Similarity ^@ Belongs to the RNA 3'-terminal cyclase family. Type 1 subfamily.|||Catalyzes the conversion of 3'-phosphate to a 2',3'-cyclic phosphodiester at the end of RNA. The mechanism of action of the enzyme occurs in 3 steps: (A) adenylation of the enzyme by ATP; (B) transfer of adenylate to an RNA-N3'P to produce RNA-N3'PP5'A; (C) and attack of the adjacent 2'-hydroxyl on the 3'-phosphorus in the diester linkage to produce the cyclic end product. The biological role of this enzyme is unknown but it is likely to function in some aspects of cellular RNA processing. http://togogenome.org/gene/59894:LOC101818850 ^@ http://purl.uniprot.org/uniprot/U3JWK2 ^@ Similarity ^@ Belongs to the dpy-30 family. http://togogenome.org/gene/59894:MTO1 ^@ http://purl.uniprot.org/uniprot/U3JX70 ^@ Function|||Similarity ^@ Belongs to the MnmG family.|||Involved in the 5-carboxymethylaminomethyl modification (mnm(5)s(2)U34) of the wobble uridine base in mitochondrial tRNAs. http://togogenome.org/gene/59894:SMPX ^@ http://purl.uniprot.org/uniprot/U3JNK8 ^@ Function|||Similarity ^@ Belongs to the SMPX family.|||Plays a role in the regulatory network through which muscle cells coordinate their structural and functional states during growth, adaptation, and repair. http://togogenome.org/gene/59894:CHEK1 ^@ http://purl.uniprot.org/uniprot/U3JRB8 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. NIM1 subfamily. http://togogenome.org/gene/59894:FAM3C ^@ http://purl.uniprot.org/uniprot/A0A803WCB1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the FAM3 family.|||Secreted http://togogenome.org/gene/59894:PITX2 ^@ http://purl.uniprot.org/uniprot/A0A803WGM6|||http://purl.uniprot.org/uniprot/U3JVG7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59894:PRKACB ^@ http://purl.uniprot.org/uniprot/A0A803VEG6|||http://purl.uniprot.org/uniprot/A0A803VXW9|||http://purl.uniprot.org/uniprot/A0A803WEF3 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. cAMP subfamily. http://togogenome.org/gene/59894:LOC101821174 ^@ http://purl.uniprot.org/uniprot/U3KLB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the histone H1/H5 family.|||Nucleus http://togogenome.org/gene/59894:RBP5 ^@ http://purl.uniprot.org/uniprot/U3JPT7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:PIGG ^@ http://purl.uniprot.org/uniprot/A0A803VXT1|||http://purl.uniprot.org/uniprot/U3JS33 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PIGG/PIGN/PIGO family. PIGG subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:ERRFI1 ^@ http://purl.uniprot.org/uniprot/A0A803W1X3 ^@ Subcellular Location Annotation ^@ Membrane|||Nucleus http://togogenome.org/gene/59894:TROVE2 ^@ http://purl.uniprot.org/uniprot/U3JJT1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ro 60 kDa family.|||Cytoplasm http://togogenome.org/gene/59894:GLB1L ^@ http://purl.uniprot.org/uniprot/U3JNR1 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 35 family. http://togogenome.org/gene/59894:TPM2 ^@ http://purl.uniprot.org/uniprot/U3JHL6|||http://purl.uniprot.org/uniprot/U3JHL9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59894:ADPRHL2 ^@ http://purl.uniprot.org/uniprot/A0A803WGU8 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/59894:PITX3 ^@ http://purl.uniprot.org/uniprot/A0A803VKN2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paired homeobox family. Bicoid subfamily.|||Nucleus http://togogenome.org/gene/59894:ENY2 ^@ http://purl.uniprot.org/uniprot/U3JUD0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the ENY2 family.|||Component of the nuclear pore complex (NPC)-associated TREX-2 complex (transcription and export complex 2). Component of the SAGA transcription coactivator-HAT complex. Within the SAGA complex, participates to a subcomplex of SAGA called the DUB module (deubiquitination module).|||Involved in mRNA export coupled transcription activation by association with both the TREX-2 and the SAGA complexes. The transcription regulatory histone acetylation (HAT) complex SAGA is a multiprotein complex that activates transcription by remodeling chromatin and mediating histone acetylation and deubiquitination. Within the SAGA complex, participates to a subcomplex that specifically deubiquitinates histones. The SAGA complex is recruited to specific gene promoters by activators, where it is required for transcription. The TREX-2 complex functions in docking export-competent ribonucleoprotein particles (mRNPs) to the nuclear entrance of the nuclear pore complex (nuclear basket). TREX-2 participates in mRNA export and accurate chromatin positioning in the nucleus by tethering genes to the nuclear periphery.|||nucleoplasm http://togogenome.org/gene/59894:LAMC2 ^@ http://purl.uniprot.org/uniprot/U3JK44 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/59894:NUP35 ^@ http://purl.uniprot.org/uniprot/U3KFE4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Nup35 family.|||Functions as a component of the nuclear pore complex (NPC).|||nuclear pore complex http://togogenome.org/gene/59894:CCDC181 ^@ http://purl.uniprot.org/uniprot/A0A803W097|||http://purl.uniprot.org/uniprot/U3JT95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CCDC181 family.|||Microtubule-binding protein that localizes to the microtubular manchette of elongating spermatids.|||cytoskeleton|||flagellum http://togogenome.org/gene/59894:LOC101812664 ^@ http://purl.uniprot.org/uniprot/U3JIC8 ^@ Similarity ^@ Belongs to the DNA photolyase class-1 family. http://togogenome.org/gene/59894:ALG14 ^@ http://purl.uniprot.org/uniprot/U3JI64 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALG14 family.|||Membrane|||Nucleus membrane http://togogenome.org/gene/59894:DHRS7 ^@ http://purl.uniprot.org/uniprot/U3JLE6 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:RFTN2 ^@ http://purl.uniprot.org/uniprot/U3JNT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the raftlin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:FZD6 ^@ http://purl.uniprot.org/uniprot/U3JTU0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the G-protein coupled receptor Fz/Smo family.|||Cell membrane|||Cell surface|||Cytoplasmic vesicle membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101818535 ^@ http://purl.uniprot.org/uniprot/U3KHV8 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59894:FMN2 ^@ http://purl.uniprot.org/uniprot/A0A803VW23|||http://purl.uniprot.org/uniprot/U3KFG0 ^@ Similarity ^@ Belongs to the formin homology family. Cappuccino subfamily. http://togogenome.org/gene/59894:IL15RA ^@ http://purl.uniprot.org/uniprot/U3JRG4 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:LOC101809685 ^@ http://purl.uniprot.org/uniprot/U3JRM7 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:MAFG ^@ http://purl.uniprot.org/uniprot/A0A803VYL3 ^@ Similarity ^@ Belongs to the bZIP family. Maf subfamily. http://togogenome.org/gene/59894:IGF1 ^@ http://purl.uniprot.org/uniprot/U3K384 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the insulin family.|||Secreted http://togogenome.org/gene/59894:COQ7 ^@ http://purl.uniprot.org/uniprot/A0A803V8T2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the COQ7 family.|||Binds 2 iron ions per subunit.|||Catalyzes the hydroxylation of 2-polyprenyl-3-methyl-6-methoxy-1,4-benzoquinol (DMQH2) during ubiquinone biosynthesis. Has also a structural role in the COQ enzyme complex, stabilizing other COQ polypeptides. Involved in lifespan determination in a ubiquinone-independent manner.|||Component of a multi-subunit COQ enzyme complex, composed of at least COQ3, COQ4, COQ5, COQ6, COQ7 and COQ9. Interacts with ADCK4 and COQ6. Interacts with COQ9.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:RICTOR ^@ http://purl.uniprot.org/uniprot/U3JH63 ^@ Similarity ^@ Belongs to the RICTOR family. http://togogenome.org/gene/59894:LOC101806455 ^@ http://purl.uniprot.org/uniprot/U3KLL3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SSTR3 ^@ http://purl.uniprot.org/uniprot/U3KLD3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LSM3 ^@ http://purl.uniprot.org/uniprot/U3KDT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the snRNP Sm proteins family.|||Binds specifically to the 3'-terminal U-tract of U6 snRNA.|||LSm subunits form a heteromer with a doughnut shape.|||Nucleus http://togogenome.org/gene/59894:TXLNB ^@ http://purl.uniprot.org/uniprot/U3KEB9 ^@ Similarity ^@ Belongs to the taxilin family. http://togogenome.org/gene/59894:LOC101815304 ^@ http://purl.uniprot.org/uniprot/U3JHD3 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. Dynamin/Fzo/YdjA family. http://togogenome.org/gene/59894:SLC39A6 ^@ http://purl.uniprot.org/uniprot/U3JR77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ZFX ^@ http://purl.uniprot.org/uniprot/A0A803VG54|||http://purl.uniprot.org/uniprot/A0A803VSQ2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:FAM150B ^@ http://purl.uniprot.org/uniprot/U3JH29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ALKAL family.|||Secreted http://togogenome.org/gene/59894:SPOPL ^@ http://purl.uniprot.org/uniprot/A0A803WFP6 ^@ Similarity ^@ Belongs to the Tdpoz family. http://togogenome.org/gene/59894:BPNT1 ^@ http://purl.uniprot.org/uniprot/A0A803VN49 ^@ Similarity ^@ Belongs to the inositol monophosphatase superfamily. http://togogenome.org/gene/59894:RPP30 ^@ http://purl.uniprot.org/uniprot/U3JZ38 ^@ Similarity ^@ Belongs to the eukaryotic/archaeal RNase P protein component 3 family. http://togogenome.org/gene/59894:GJC1 ^@ http://purl.uniprot.org/uniprot/U3KIS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family. Gamma-type subfamily.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:NTRK3 ^@ http://purl.uniprot.org/uniprot/U3K773 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. Insulin receptor subfamily.|||Membrane http://togogenome.org/gene/59894:DOLPP1 ^@ http://purl.uniprot.org/uniprot/U3JFD6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the dolichyldiphosphatase family.|||Endoplasmic reticulum membrane|||Membrane|||Required for efficient N-glycosylation. Necessary for maintaining optimal levels of dolichol-linked oligosaccharides. Hydrolyzes dolichyl pyrophosphate at a very high rate and dolichyl monophosphate at a much lower rate. Does not act on phosphatidate. http://togogenome.org/gene/59894:DDX4 ^@ http://purl.uniprot.org/uniprot/A0A803V8I5 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/59894:POLL ^@ http://purl.uniprot.org/uniprot/U3K1T5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA polymerase type-X family.|||Nucleus http://togogenome.org/gene/59894:ITGB2 ^@ http://purl.uniprot.org/uniprot/U3KFV9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/59894:SNED1 ^@ http://purl.uniprot.org/uniprot/U3JLH2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:EPC2 ^@ http://purl.uniprot.org/uniprot/A0A803WDH0|||http://purl.uniprot.org/uniprot/U3KHG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enhancer of polycomb family.|||Nucleus http://togogenome.org/gene/59894:PSMD12 ^@ http://purl.uniprot.org/uniprot/U3JI97 ^@ Similarity ^@ Belongs to the proteasome subunit p55 family. http://togogenome.org/gene/59894:OTOP3 ^@ http://purl.uniprot.org/uniprot/U3JEU8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the otopetrin family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CA7 ^@ http://purl.uniprot.org/uniprot/U3JZ42 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:MGRN1 ^@ http://purl.uniprot.org/uniprot/A0A803V9F2|||http://purl.uniprot.org/uniprot/A0A803WAY9|||http://purl.uniprot.org/uniprot/U3JNR2 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||E3 ubiquitin ligase. http://togogenome.org/gene/59894:CHRM3 ^@ http://purl.uniprot.org/uniprot/U3KL06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Muscarinic acetylcholine receptor subfamily.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||The muscarinic acetylcholine receptor mediates various cellular responses, including inhibition of adenylate cyclase, breakdown of phosphoinositides and modulation of potassium channels through the action of G proteins. Primary transducing effect is Pi turnover. http://togogenome.org/gene/59894:CZH5orf28 ^@ http://purl.uniprot.org/uniprot/A0A803V209 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ENTPD8 ^@ http://purl.uniprot.org/uniprot/U3JRJ5 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:LOC101810599 ^@ http://purl.uniprot.org/uniprot/A0A803VGY1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CALHM family.|||Membrane http://togogenome.org/gene/59894:TBR1 ^@ http://purl.uniprot.org/uniprot/U3JPF3 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:DCAF13 ^@ http://purl.uniprot.org/uniprot/U3JTX9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat DCAF13/WDSOF1 family.|||nucleolus http://togogenome.org/gene/59894:ND4 ^@ http://purl.uniprot.org/uniprot/S0ARW2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 4 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:ROCK1 ^@ http://purl.uniprot.org/uniprot/U3JUJ8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:DRAXIN ^@ http://purl.uniprot.org/uniprot/U3K681 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the draxin family.|||Chemorepulsive axon guidance protein required for the development of spinal cord and forebrain commissures. Acts as a chemorepulsive guidance protein for commissural axons during development. Able to inhibit or repel neurite outgrowth from dorsal spinal cord.|||Secreted http://togogenome.org/gene/59894:FRK ^@ http://purl.uniprot.org/uniprot/U3K8V7 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:C9 ^@ http://purl.uniprot.org/uniprot/A0A803W223|||http://purl.uniprot.org/uniprot/U3JH47 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complement C6/C7/C8/C9 family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Secreted|||Target cell membrane http://togogenome.org/gene/59894:TMEM206 ^@ http://purl.uniprot.org/uniprot/U3KD60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the proton-activated chloride channel family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:KLHL3 ^@ http://purl.uniprot.org/uniprot/A0A803W9E2|||http://purl.uniprot.org/uniprot/U3K089 ^@ Subcellular Location Annotation ^@ cytoskeleton|||cytosol http://togogenome.org/gene/59894:PENK ^@ http://purl.uniprot.org/uniprot/U3K6V5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the opioid neuropeptide precursor family.|||Secreted http://togogenome.org/gene/59894:AHSA1 ^@ http://purl.uniprot.org/uniprot/U3KDX3 ^@ Similarity ^@ Belongs to the AHA1 family. http://togogenome.org/gene/59894:RUVBL1 ^@ http://purl.uniprot.org/uniprot/U3JZN2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RuvB family.|||Dynein axonemal particle|||Nucleus|||Proposed core component of the chromatin remodeling Ino80 complex which exhibits DNA- and nucleosome-activated ATPase activity and catalyzes ATP-dependent nucleosome sliding. http://togogenome.org/gene/59894:LOC101818061 ^@ http://purl.uniprot.org/uniprot/U3JZB7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:TBC1D7 ^@ http://purl.uniprot.org/uniprot/U3KG05 ^@ Subcellular Location Annotation ^@ Cytoplasmic vesicle|||Vesicle http://togogenome.org/gene/59894:RPS6KB2 ^@ http://purl.uniprot.org/uniprot/U3KCI2 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59894:MYOG ^@ http://purl.uniprot.org/uniprot/A0A803V2D9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:KATNAL1 ^@ http://purl.uniprot.org/uniprot/U3K1H1 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ ATPase activity is stimulated by microtubules, which promote homooligomerization. ATP-dependent microtubule severing is stimulated by interaction with KATNB1.|||Belongs to the AAA ATPase family. Katanin p60 subunit A1 subfamily. A-like 1 sub-subfamily.|||Can homooligomerize into hexameric rings, which may be promoted by interaction with microtubules. Interacts with KATNB1, which may serve as a targeting subunit.|||Catalytic subunit of a complex which severs microtubules in an ATP-dependent manner. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||Cytoplasm|||Interacts with KATNB1 and KATNBL1.|||Regulates microtubule dynamics in Sertoli cells, a process that is essential for spermiogenesis and male fertility. Severs microtubules in an ATP-dependent manner, promoting rapid reorganization of cellular microtubule arrays.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/59894:NIPAL2 ^@ http://purl.uniprot.org/uniprot/U3JT56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/59894:EME1 ^@ http://purl.uniprot.org/uniprot/U3JF12 ^@ Similarity ^@ Belongs to the EME1/MMS4 family. http://togogenome.org/gene/59894:NOC3L ^@ http://purl.uniprot.org/uniprot/U3JZD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CBF/MAK21 family.|||nucleolus http://togogenome.org/gene/59894:LOC101805779 ^@ http://purl.uniprot.org/uniprot/U3JM77 ^@ Similarity ^@ Belongs to the carbohydrate kinase PfkB family. http://togogenome.org/gene/59894:DUOXA2 ^@ http://purl.uniprot.org/uniprot/A0A803W4W5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DUOXA family.|||Membrane http://togogenome.org/gene/59894:CRYBB3 ^@ http://purl.uniprot.org/uniprot/U3K1V1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the beta/gamma-crystallin family.|||Crystallins are the dominant structural components of the vertebrate eye lens.|||Homo/heterodimer, or complexes of higher-order. The structure of beta-crystallin oligomers seems to be stabilized through interactions between the N-terminal arms. http://togogenome.org/gene/59894:WNT2 ^@ http://purl.uniprot.org/uniprot/A0A803VJY3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:EIF4E2 ^@ http://purl.uniprot.org/uniprot/U3JZ76 ^@ Similarity ^@ Belongs to the eukaryotic initiation factor 4E family. http://togogenome.org/gene/59894:METTL14 ^@ http://purl.uniprot.org/uniprot/U3JHF7 ^@ Similarity ^@ Belongs to the MT-A70-like family. http://togogenome.org/gene/59894:LOC101814157 ^@ http://purl.uniprot.org/uniprot/U3KLL6 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:AIMP2 ^@ http://purl.uniprot.org/uniprot/A0A803V315 ^@ Subcellular Location Annotation ^@ Nucleus|||cytosol http://togogenome.org/gene/59894:HSD17B12 ^@ http://purl.uniprot.org/uniprot/U3KD30 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:LOC101819452 ^@ http://purl.uniprot.org/uniprot/U3JH19 ^@ Similarity ^@ Belongs to the cysteine synthase/cystathionine beta-synthase family. http://togogenome.org/gene/59894:SEC22B ^@ http://purl.uniprot.org/uniprot/U3JLU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptobrevin family.|||Endoplasmic reticulum membrane|||Endoplasmic reticulum-Golgi intermediate compartment membrane|||Melanosome|||Membrane|||SNARE involved in targeting and fusion of ER-derived transport vesicles with the Golgi complex as well as Golgi-derived retrograde transport vesicles with the ER.|||cis-Golgi network membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:TENM1 ^@ http://purl.uniprot.org/uniprot/A0A803VIC3|||http://purl.uniprot.org/uniprot/U3JFL0 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the tenascin family. Teneurin subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:CAMK1D ^@ http://purl.uniprot.org/uniprot/A0A803VNC0|||http://purl.uniprot.org/uniprot/A0A803VVD5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:ENKUR ^@ http://purl.uniprot.org/uniprot/A0A803V5U1 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/59894:HSPA14 ^@ http://purl.uniprot.org/uniprot/U3JGU7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the heat shock protein 70 family.|||cytosol http://togogenome.org/gene/59894:CDC5L ^@ http://purl.uniprot.org/uniprot/U3KDY3 ^@ Similarity ^@ Belongs to the CEF1 family. http://togogenome.org/gene/59894:MAT2B ^@ http://purl.uniprot.org/uniprot/A0A803VN44|||http://purl.uniprot.org/uniprot/U3KGJ3 ^@ Function|||Similarity|||Subunit ^@ Belongs to the dTDP-4-dehydrorhamnose reductase family. MAT2B subfamily.|||Heterotrimer; composed of a catalytic MAT2A homodimer that binds one regulatory MAT2B chain. Heterohexamer; composed of a central, catalytic MAT2A homotetramer flanked on either side by a regulatory MAT2B chain. NADP binding increases the affinity for MAT2A.|||Regulatory subunit of S-adenosylmethionine synthetase 2, an enzyme that catalyzes the formation of S-adenosylmethionine from methionine and ATP. Regulates MAT2A catalytic activity by changing its kinetic properties, increasing its affinity for L-methionine. http://togogenome.org/gene/59894:LOC101811954 ^@ http://purl.uniprot.org/uniprot/A0A803W5M8 ^@ Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome c family.|||Binds 1 heme group per subunit.|||Electron carrier protein. The oxidized form of the cytochrome c heme group can accept an electron from the heme group of the cytochrome c1 subunit of cytochrome reductase. Cytochrome c then transfers this electron to the cytochrome oxidase complex, the final protein carrier in the mitochondrial electron-transport chain.|||Mitochondrion intermembrane space http://togogenome.org/gene/59894:PSPC1 ^@ http://purl.uniprot.org/uniprot/U3K275 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PSPC family.|||Cytoplasm|||Nucleus matrix|||Nucleus speckle|||nucleolus http://togogenome.org/gene/59894:LOC101808279 ^@ http://purl.uniprot.org/uniprot/A0A803W4P6|||http://purl.uniprot.org/uniprot/U3KFX2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family.|||Membrane http://togogenome.org/gene/59894:GNG2 ^@ http://purl.uniprot.org/uniprot/U3JGU5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G protein gamma family.|||Cell membrane|||G proteins are composed of 3 units; alpha, beta and gamma.|||Guanine nucleotide-binding proteins (G proteins) are involved as a modulator or transducer in various transmembrane signaling systems. The beta and gamma chains are required for the GTPase activity, for replacement of GDP by GTP, and for G protein-effector interaction. http://togogenome.org/gene/59894:PRIMPOL ^@ http://purl.uniprot.org/uniprot/U3KB76 ^@ Similarity ^@ Belongs to the eukaryotic-type primase small subunit family. http://togogenome.org/gene/59894:ELK3 ^@ http://purl.uniprot.org/uniprot/U3K8L1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:LOC101812019 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:LITAF ^@ http://purl.uniprot.org/uniprot/A0A803VPG4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CDIP1/LITAF family.|||Lysosome membrane|||Membrane http://togogenome.org/gene/59894:LOC101818425 ^@ http://purl.uniprot.org/uniprot/U3K731 ^@ Similarity ^@ Belongs to the CRISP family. http://togogenome.org/gene/59894:ENO2 ^@ http://purl.uniprot.org/uniprot/U3JQ01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the enolase family.|||Cytoplasm http://togogenome.org/gene/59894:NRXN1 ^@ http://purl.uniprot.org/uniprot/A0A803V6H6|||http://purl.uniprot.org/uniprot/U3K8Y5 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:FKTN ^@ http://purl.uniprot.org/uniprot/U3JJR3 ^@ Similarity ^@ Belongs to the LicD transferase family. http://togogenome.org/gene/59894:TUBGCP4 ^@ http://purl.uniprot.org/uniprot/A0A803WC93|||http://purl.uniprot.org/uniprot/U3KA61 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TUBGCP family.|||Gamma-tubulin complex is necessary for microtubule nucleation at the centrosome.|||centrosome http://togogenome.org/gene/59894:TNFRSF25 ^@ http://purl.uniprot.org/uniprot/A0A803W014|||http://purl.uniprot.org/uniprot/U3K5B9 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:WDR12 ^@ http://purl.uniprot.org/uniprot/U3JN44 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat WDR12/YTM1 family.|||Component of the PeBoW complex, composed of BOP1, PES1 and WDR12. Within the PeBoW complex BOP1 interacts directly with PES1 and WDR12. The PeBoW complex also associates with the 66S pre-ribosome.|||Component of the PeBoW complex, which is required for maturation of 28S and 5.8S ribosomal RNAs and formation of the 60S ribosome.|||nucleolus|||nucleoplasm http://togogenome.org/gene/59894:LOC101808861 ^@ http://purl.uniprot.org/uniprot/U3KEV7 ^@ Similarity ^@ Belongs to the AccD/PCCB family. http://togogenome.org/gene/59894:CITED2 ^@ http://purl.uniprot.org/uniprot/U3KKR2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CITED family.|||Nucleus http://togogenome.org/gene/59894:NOX4 ^@ http://purl.uniprot.org/uniprot/A0A803V169 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101810615 ^@ http://purl.uniprot.org/uniprot/A0A803VCK6 ^@ Subcellular Location Annotation|||Subunit ^@ Apical cell membrane|||Cell membrane|||Homodimer.|||Membrane http://togogenome.org/gene/59894:TSSC1 ^@ http://purl.uniprot.org/uniprot/U3JH87 ^@ Similarity ^@ Belongs to the WD repeat EIPR1 family. http://togogenome.org/gene/59894:NR0B2 ^@ http://purl.uniprot.org/uniprot/U3JVH3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR0 subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:CNN2 ^@ http://purl.uniprot.org/uniprot/U3KHU0 ^@ Function|||Similarity ^@ Belongs to the calponin family.|||Thin filament-associated protein that is implicated in the regulation and modulation of smooth muscle contraction. It is capable of binding to actin, calmodulin and tropomyosin. The interaction of calponin with actin inhibits the actomyosin Mg-ATPase activity. http://togogenome.org/gene/59894:GNB4 ^@ http://purl.uniprot.org/uniprot/U3K127 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/59894:LOC101810038 ^@ http://purl.uniprot.org/uniprot/U3K1U7 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:LTBP2 ^@ http://purl.uniprot.org/uniprot/U3JUW1 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:MMP9 ^@ http://purl.uniprot.org/uniprot/A0A803WDU2|||http://purl.uniprot.org/uniprot/U3JQ15 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M10A family.|||extracellular matrix http://togogenome.org/gene/59894:RHAG ^@ http://purl.uniprot.org/uniprot/U3KE41 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane http://togogenome.org/gene/59894:SIX4 ^@ http://purl.uniprot.org/uniprot/A0A803V2H6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SEC16A ^@ http://purl.uniprot.org/uniprot/A0A803WGF8|||http://purl.uniprot.org/uniprot/U3JGA6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the SEC16 family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Membrane|||Plays a role in the organization of the endoplasmic reticulum exit sites (ERES), also known as transitional endoplasmic reticulum (tER). Required for secretory cargo traffic from the endoplasmic reticulum to the Golgi apparatus.|||SEC16A and SEC16B are each present in multiple copies in a heteromeric complex. http://togogenome.org/gene/59894:LDB1 ^@ http://purl.uniprot.org/uniprot/U3K1G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDB family.|||Nucleus http://togogenome.org/gene/59894:ESRRG ^@ http://purl.uniprot.org/uniprot/A0A803VZ46|||http://purl.uniprot.org/uniprot/A0A803W1W7|||http://purl.uniprot.org/uniprot/A0A803WC39 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nuclear hormone receptor family. NR3 subfamily.|||Nucleus http://togogenome.org/gene/59894:NPY ^@ http://purl.uniprot.org/uniprot/U3KJ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NPY family.|||Secreted http://togogenome.org/gene/59894:LOC101816138 ^@ http://purl.uniprot.org/uniprot/U3KIP7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the claudin family.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:ARF1 ^@ http://purl.uniprot.org/uniprot/A0A803VL11 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small GTPase superfamily. Arf family.|||GTP-binding protein involved in protein trafficking; modulates vesicle budding and uncoating within the Golgi apparatus.|||Golgi apparatus http://togogenome.org/gene/59894:PLPP3 ^@ http://purl.uniprot.org/uniprot/U3KCN3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/59894:LOC101816509 ^@ http://purl.uniprot.org/uniprot/A0A803VDK8|||http://purl.uniprot.org/uniprot/U3K045 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the organo anion transporter (TC 2.A.60) family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:AKIRIN2 ^@ http://purl.uniprot.org/uniprot/A0A803VTN5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the akirin family.|||Nucleus http://togogenome.org/gene/59894:NME5 ^@ http://purl.uniprot.org/uniprot/U3JYX3 ^@ Similarity ^@ Belongs to the NDK family. http://togogenome.org/gene/59894:RND3 ^@ http://purl.uniprot.org/uniprot/U3KHG7 ^@ Function ^@ Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. http://togogenome.org/gene/59894:LOC101817831 ^@ http://purl.uniprot.org/uniprot/U3KLL9 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:GHR ^@ http://purl.uniprot.org/uniprot/A0A803VXF5 ^@ Function|||Similarity ^@ Belongs to the type I cytokine receptor family. Type 1 subfamily.|||The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. http://togogenome.org/gene/59894:TBL1XR1 ^@ http://purl.uniprot.org/uniprot/U3K169 ^@ Similarity ^@ Belongs to the WD repeat EBI family. http://togogenome.org/gene/59894:ADAMTS18 ^@ http://purl.uniprot.org/uniprot/U3JC10 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:F5 ^@ http://purl.uniprot.org/uniprot/U3JTG7 ^@ Similarity ^@ Belongs to the multicopper oxidase family. http://togogenome.org/gene/59894:LAPTM5 ^@ http://purl.uniprot.org/uniprot/U3JEV2 ^@ Similarity ^@ Belongs to the LAPTM4/LAPTM5 transporter family. http://togogenome.org/gene/59894:GRM5 ^@ http://purl.uniprot.org/uniprot/A0A803VBM7|||http://purl.uniprot.org/uniprot/A0A803VNZ3|||http://purl.uniprot.org/uniprot/U3JZL0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SSU72 ^@ http://purl.uniprot.org/uniprot/U3K406 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSU72 phosphatase family.|||Nucleus|||Protein phosphatase that catalyzes the dephosphorylation of the C-terminal domain of RNA polymerase II. Plays a role in RNA processing and termination. http://togogenome.org/gene/59894:CDH22 ^@ http://purl.uniprot.org/uniprot/U3JQH5 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SUPT3H ^@ http://purl.uniprot.org/uniprot/U3KDX2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:IRF2 ^@ http://purl.uniprot.org/uniprot/U3KB45 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the IRF family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Nucleus http://togogenome.org/gene/59894:SENP5 ^@ http://purl.uniprot.org/uniprot/U3K0I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C48 family.|||nucleolus http://togogenome.org/gene/59894:TMEM159 ^@ http://purl.uniprot.org/uniprot/U3KHX8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LDAF1 family.|||Endoplasmic reticulum membrane|||Lipid droplet|||Membrane http://togogenome.org/gene/59894:TP73 ^@ http://purl.uniprot.org/uniprot/U3K4S7 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Cytoplasm|||Found in a complex with p53/TP53 and CABLES1.|||Nucleus|||Participates in the apoptotic response to DNA damage. Isoforms containing the transactivation domain are pro-apoptotic, isoforms lacking the domain are anti-apoptotic and block the function of p53 and transactivating p73 isoforms. May be a tumor suppressor protein. http://togogenome.org/gene/59894:DDX6 ^@ http://purl.uniprot.org/uniprot/U3K5F1 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/59894:LOC101811650 ^@ http://purl.uniprot.org/uniprot/U3JZP6 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:SLC6A7 ^@ http://purl.uniprot.org/uniprot/U3JZX1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:ZDHHC20 ^@ http://purl.uniprot.org/uniprot/U3K239 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:HAP1 ^@ http://purl.uniprot.org/uniprot/A0A803V3K2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/59894:CEP170 ^@ http://purl.uniprot.org/uniprot/A0A803V5P8|||http://purl.uniprot.org/uniprot/A0A803VVF1|||http://purl.uniprot.org/uniprot/A0A803W3L0 ^@ Similarity ^@ Belongs to the CEP170 family. http://togogenome.org/gene/59894:TRAPPC13 ^@ http://purl.uniprot.org/uniprot/A0A803WG12|||http://purl.uniprot.org/uniprot/U3K584 ^@ Similarity|||Subunit ^@ Belongs to the TRAPPC13 family.|||Part of the multisubunit TRAPP (transport protein particle) complex. http://togogenome.org/gene/59894:PANX2 ^@ http://purl.uniprot.org/uniprot/U3K4Y3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the pannexin family.|||Cell membrane|||Membrane|||Structural component of the gap junctions and the hemichannels.|||gap junction http://togogenome.org/gene/59894:LOC101819425 ^@ http://purl.uniprot.org/uniprot/A0A803VXT8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the V-ATPase e1/e2 subunit family.|||Membrane|||Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment.|||V-ATPase is a heteromultimeric enzyme made up of two complexes: the ATP-hydrolytic V1 complex and the proton translocation V0 complex. http://togogenome.org/gene/59894:PRDM1 ^@ http://purl.uniprot.org/uniprot/A0A803WFW5|||http://purl.uniprot.org/uniprot/U3KAS5 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the class V-like SAM-binding methyltransferase superfamily.|||Cytoplasm|||Interacts with PRMT5. Interacts with FBXO10. Interacts with FBXO11.|||Nucleus|||Transcription factor that mediates a transcriptional program in various innate and adaptive immune tissue-resident lymphocyte T cell types such as tissue-resident memory T (Trm), natural killer (trNK) and natural killer T (NKT) cells and negatively regulates gene expression of proteins that promote the egress of tissue-resident T-cell populations from non-lymphoid organs. Plays a role in the development, retention and long-term establishment of adaptive and innate tissue-resident lymphocyte T cell types in non-lymphoid organs, such as the skin and gut, but also in other nonbarrier tissues like liver and kidney, and therefore may provide immediate immunological protection against reactivating infections or viral reinfection. Binds specifically to the PRDI element in the promoter of the beta-interferon gene. Drives the maturation of B-lymphocytes into Ig secreting cells. Associates with the transcriptional repressor ZNF683 to chromatin at gene promoter regions. http://togogenome.org/gene/59894:CNIH3 ^@ http://purl.uniprot.org/uniprot/U3KB67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cornichon family.|||Membrane http://togogenome.org/gene/59894:INTS9 ^@ http://purl.uniprot.org/uniprot/A0A803VLD1|||http://purl.uniprot.org/uniprot/U3K8H4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the metallo-beta-lactamase superfamily. RNA-metabolizing metallo-beta-lactamase-like family. INTS9 subfamily.|||Nucleus http://togogenome.org/gene/59894:CTNND1 ^@ http://purl.uniprot.org/uniprot/A0A803VMK1 ^@ Similarity ^@ Belongs to the beta-catenin family. http://togogenome.org/gene/59894:FAM83H ^@ http://purl.uniprot.org/uniprot/A0A803W3N4 ^@ Similarity ^@ Belongs to the FAM83 family. http://togogenome.org/gene/59894:CD40 ^@ http://purl.uniprot.org/uniprot/U3JQG8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:AKAP1 ^@ http://purl.uniprot.org/uniprot/U3JQW9 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:GPBP1L1 ^@ http://purl.uniprot.org/uniprot/U3K4K0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vasculin family.|||Nucleus http://togogenome.org/gene/59894:HMGCR ^@ http://purl.uniprot.org/uniprot/U3K660 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HMG-CoA reductase family.|||Endoplasmic reticulum membrane|||Membrane|||Peroxisome membrane http://togogenome.org/gene/59894:GJB3 ^@ http://purl.uniprot.org/uniprot/A0A803VDH8 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ A connexon is composed of a hexamer of connexins.|||Belongs to the connexin family.|||Cell membrane|||Membrane|||One gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell.|||gap junction http://togogenome.org/gene/59894:LMNA ^@ http://purl.uniprot.org/uniprot/U3JIT9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:GPR39 ^@ http://purl.uniprot.org/uniprot/A0A803VBB8 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:KLC1 ^@ http://purl.uniprot.org/uniprot/U3JJN4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the kinesin light chain family.|||Kinesin is a microtubule-associated force-producing protein that play a role in organelle transport.|||Oligomeric complex composed of two heavy chains and two light chains.|||cytoskeleton http://togogenome.org/gene/59894:ACER1 ^@ http://purl.uniprot.org/uniprot/A0A803V5J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the alkaline ceramidase family.|||Hydrolyzes the sphingolipid ceramide into sphingosine and free fatty acid.|||Membrane http://togogenome.org/gene/59894:NBR1 ^@ http://purl.uniprot.org/uniprot/A0A803V047|||http://purl.uniprot.org/uniprot/U3JDH9 ^@ Subcellular Location Annotation ^@ autophagosome http://togogenome.org/gene/59894:CRHR1 ^@ http://purl.uniprot.org/uniprot/U3K060 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:JAK2 ^@ http://purl.uniprot.org/uniprot/U3K7L6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily.|||Endomembrane system|||Nucleus http://togogenome.org/gene/59894:SLC25A38 ^@ http://purl.uniprot.org/uniprot/A0A803VCX3|||http://purl.uniprot.org/uniprot/U3KD19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family. SLC25A38 subfamily.|||Membrane|||Mitochondrial glycine transporter that imports glycine into the mitochondrial matrix. Plays an important role in providing glycine for the first enzymatic step in heme biosynthesis, the condensation of glycine with succinyl-CoA to produce 5-aminolevulinate (ALA) in the miochondrial matrix. Required during erythropoiesis.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:LOC101819515 ^@ http://purl.uniprot.org/uniprot/U3K8K7 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:SLC20A2 ^@ http://purl.uniprot.org/uniprot/A0A803VH75|||http://purl.uniprot.org/uniprot/U3JVH6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the inorganic phosphate transporter (PiT) (TC 2.A.20) family.|||Membrane|||Sodium-phosphate symporter which plays a fundamental housekeeping role in phosphate transport. http://togogenome.org/gene/59894:LOC101816948 ^@ http://purl.uniprot.org/uniprot/U3JRK3 ^@ Similarity ^@ Belongs to the cornifelin family. http://togogenome.org/gene/59894:GATA4 ^@ http://purl.uniprot.org/uniprot/A0A803VPC6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:KCNJ12 ^@ http://purl.uniprot.org/uniprot/A0A803VD75 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101821194 ^@ http://purl.uniprot.org/uniprot/U3K252 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cytochrome P450 family.|||Conversion of pregnenolone and progesterone to their 17-alpha-hydroxylated products and subsequently to dehydroepiandrosterone (DHEA) and androstenedione. Catalyzes both the 17-alpha-hydroxylation and the 17,20-lyase reaction.|||Membrane http://togogenome.org/gene/59894:LOC101808699 ^@ http://purl.uniprot.org/uniprot/A0A803WA56 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:PSAP ^@ http://purl.uniprot.org/uniprot/U3KFJ0 ^@ Function|||Subcellular Location Annotation ^@ Prosaposin: Behaves as a myelinotrophic and neurotrophic factor, these effects are mediated by its G-protein-coupled receptors, GPR37 and GPR37L1, undergoing ligand-mediated internalization followed by ERK phosphorylation signaling.|||Saposins are specific low-molecular mass non-enzymic proteins, they participate in the lysosomal degradation of sphingolipids, which takes place by the sequential action of specific hydrolases.|||Secreted http://togogenome.org/gene/59894:IL18R1 ^@ http://purl.uniprot.org/uniprot/U3JM45 ^@ Similarity ^@ Belongs to the interleukin-1 receptor family. http://togogenome.org/gene/59894:IPO7 ^@ http://purl.uniprot.org/uniprot/U3JE15 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:ITK ^@ http://purl.uniprot.org/uniprot/U3K153 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. http://togogenome.org/gene/59894:RSPO3 ^@ http://purl.uniprot.org/uniprot/U3KAF3 ^@ Similarity ^@ Belongs to the R-spondin family. http://togogenome.org/gene/59894:C1H11orf87 ^@ http://purl.uniprot.org/uniprot/A0A803VU00 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:IVD ^@ http://purl.uniprot.org/uniprot/U3JEE7 ^@ Similarity ^@ Belongs to the acyl-CoA dehydrogenase family. http://togogenome.org/gene/59894:NMUR2 ^@ http://purl.uniprot.org/uniprot/U3K0R3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane|||Receptor for the neuromedin-U and neuromedin-S neuropeptides. http://togogenome.org/gene/59894:VWA2 ^@ http://purl.uniprot.org/uniprot/U3JHS1 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:DNA2 ^@ http://purl.uniprot.org/uniprot/U3KEU9 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family.|||Binds 1 [4Fe-4S] cluster.|||Key enzyme involved in DNA replication and DNA repair. Involved in Okazaki fragments processing by cleaving long flaps that escape FEN1: flaps that are longer than 27 nucleotides are coated by replication protein A complex (RPA), leading to recruit DNA2 which cleaves the flap until it is too short to bind RPA and becomes a substrate for FEN1. Also involved in 5'-end resection of DNA during double-strand break (DSB) repair by mediating the cleavage of 5'-ssDNA.|||Mitochondrion|||Nucleus http://togogenome.org/gene/59894:FBXO25 ^@ http://purl.uniprot.org/uniprot/U3JH09 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TMEM38A ^@ http://purl.uniprot.org/uniprot/U3KHH5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM38 family.|||Membrane|||Monovalent cation channel required for maintenance of rapid intracellular calcium release. May act as a potassium counter-ion channel that functions in synchronization with calcium release from intracellular stores. http://togogenome.org/gene/59894:STAR ^@ http://purl.uniprot.org/uniprot/U3JW61 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ May interact with TSPO.|||Mitochondrion|||Plays a key role in steroid hormone synthesis by enhancing the metabolism of cholesterol into pregnenolone. Mediates the transfer of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane where it is cleaved to pregnenolone. http://togogenome.org/gene/59894:LOC101812386 ^@ http://purl.uniprot.org/uniprot/A0A803VKG9 ^@ Similarity ^@ Belongs to the gonadal family. http://togogenome.org/gene/59894:CDKAL1 ^@ http://purl.uniprot.org/uniprot/U3KGF0 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the methylthiotransferase family. CDKAL1 subfamily.|||Binds 1 or 2 [4Fe-4S] cluster. One cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Catalyzes the methylthiolation of N6-threonylcarbamoyladenosine (t(6)A), leading to the formation of 2-methylthio-N6-threonylcarbamoyladenosine (ms(2)t(6)A) at position 37 in tRNAs that read codons beginning with adenine.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:ADPRHL1 ^@ http://purl.uniprot.org/uniprot/U3JKW5 ^@ Similarity ^@ Belongs to the ADP-ribosylglycohydrolase family. http://togogenome.org/gene/59894:SAMM50 ^@ http://purl.uniprot.org/uniprot/U3JVV5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SAM50/omp85 family.|||Mitochondrion outer membrane http://togogenome.org/gene/59894:LOC101806896 ^@ http://purl.uniprot.org/uniprot/U3JZA9 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane http://togogenome.org/gene/59894:DDX59 ^@ http://purl.uniprot.org/uniprot/U3JJ61 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DDX59 subfamily. http://togogenome.org/gene/59894:LOC101808544 ^@ http://purl.uniprot.org/uniprot/U3KL31 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:MRAP2 ^@ http://purl.uniprot.org/uniprot/U3JJC6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MRAP family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LOC101820841 ^@ http://purl.uniprot.org/uniprot/A0A803WC00 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the major facilitator superfamily.|||Membrane http://togogenome.org/gene/59894:POLR3F ^@ http://purl.uniprot.org/uniprot/U3JYU8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPC34/RPC39 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs.|||Nucleus http://togogenome.org/gene/59894:LOC101817753 ^@ http://purl.uniprot.org/uniprot/U3K4J5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the UbiA prenyltransferase family.|||Converts protoheme IX and farnesyl diphosphate to heme O.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:GPR87 ^@ http://purl.uniprot.org/uniprot/U3JRG5 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:GNB3 ^@ http://purl.uniprot.org/uniprot/U3JQ32 ^@ Similarity ^@ Belongs to the WD repeat G protein beta family. http://togogenome.org/gene/59894:PDGFRB ^@ http://purl.uniprot.org/uniprot/U3JZS6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:LOC101808517 ^@ http://purl.uniprot.org/uniprot/U3JXL5 ^@ Similarity ^@ Belongs to the SELO family. http://togogenome.org/gene/59894:TGFBR2 ^@ http://purl.uniprot.org/uniprot/A0A803VXR4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Cell membrane|||Membrane|||Membrane raft|||Transmembrane serine/threonine kinase forming with the TGF-beta type I serine/threonine kinase receptor, TGFBR1, the non-promiscuous receptor for the TGF-beta cytokines TGFB1, TGFB2 and TGFB3. Transduces the TGFB1, TGFB2 and TGFB3 signal from the cell surface to the cytoplasm and is thus regulating a plethora of physiological and pathological processes including cell cycle arrest in epithelial and hematopoietic cells, control of mesenchymal cell proliferation and differentiation, wound healing, extracellular matrix production, immunosuppression and carcinogenesis. The formation of the receptor complex composed of 2 TGFBR1 and 2 TGFBR2 molecules symmetrically bound to the cytokine dimer results in the phosphorylation and the activation of TGFRB1 by the constitutively active TGFBR2. Activated TGFBR1 phosphorylates SMAD2 which dissociates from the receptor and interacts with SMAD4. The SMAD2-SMAD4 complex is subsequently translocated to the nucleus where it modulates the transcription of the TGF-beta-regulated genes. This constitutes the canonical SMAD-dependent TGF-beta signaling cascade. Also involved in non-canonical, SMAD-independent TGF-beta signaling pathways. http://togogenome.org/gene/59894:ABCG8 ^@ http://purl.uniprot.org/uniprot/U3KE29 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/59894:MRPS25 ^@ http://purl.uniprot.org/uniprot/U3KGX6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mS25 family.|||Mitochondrion http://togogenome.org/gene/59894:DSP ^@ http://purl.uniprot.org/uniprot/U3KFM5 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:TJP3 ^@ http://purl.uniprot.org/uniprot/U3KAU5 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/59894:SLC8A3 ^@ http://purl.uniprot.org/uniprot/A0A803V2N5|||http://purl.uniprot.org/uniprot/A0A803WGG0|||http://purl.uniprot.org/uniprot/U3JQU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Ca(2+):cation antiporter (CaCA) (TC 2.A.19) family. SLC8 subfamily.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:OSBPL3 ^@ http://purl.uniprot.org/uniprot/U3K4K8 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:ANKS1A ^@ http://purl.uniprot.org/uniprot/U3JM60 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:CSMD3 ^@ http://purl.uniprot.org/uniprot/U3JHY3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TALDO1 ^@ http://purl.uniprot.org/uniprot/A0A803VL83 ^@ Function|||Similarity ^@ Belongs to the transaldolase family. Type 1 subfamily.|||Catalyzes the rate-limiting step of the non-oxidative phase in the pentose phosphate pathway. Catalyzes the reversible conversion of sedheptulose-7-phosphate and D-glyceraldehyde 3-phosphate into erythrose-4-phosphate and beta-D-fructose 6-phosphate. http://togogenome.org/gene/59894:ELF3 ^@ http://purl.uniprot.org/uniprot/U3JJ74 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:MPV17L2 ^@ http://purl.uniprot.org/uniprot/U3JF38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peroxisomal membrane protein PXMP2/4 family.|||Membrane http://togogenome.org/gene/59894:METAP1 ^@ http://purl.uniprot.org/uniprot/A0A803W0N2|||http://purl.uniprot.org/uniprot/U3JUM5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the peptidase M24A family. Methionine aminopeptidase type 1 subfamily.|||Binds 2 divalent metal cations per subunit. Has a high-affinity and a low affinity metal-binding site. The true nature of the physiological cofactor is under debate. The enzyme is active with cobalt, zinc, manganese or divalent iron ions. Most likely, methionine aminopeptidases function as mononuclear Fe(2+)-metalloproteases under physiological conditions, and the catalytically relevant metal-binding site has been assigned to the histidine-containing high-affinity site.|||Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val). http://togogenome.org/gene/59894:ASF1A ^@ http://purl.uniprot.org/uniprot/U3K9I6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ASF1 family.|||Nucleus http://togogenome.org/gene/59894:LOC101816585 ^@ http://purl.uniprot.org/uniprot/U3JXS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type V subfamily.|||Membrane http://togogenome.org/gene/59894:MEP1A ^@ http://purl.uniprot.org/uniprot/U3JFS4 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:LOC101816392 ^@ http://purl.uniprot.org/uniprot/A0A803WGA2|||http://purl.uniprot.org/uniprot/U3JJN6 ^@ Function|||Subcellular Location Annotation ^@ Cell membrane|||Membrane|||Potential calcium-dependent cell-adhesion protein. May be involved in the establishment and maintenance of specific neuronal connections in the brain. http://togogenome.org/gene/59894:UGGT1 ^@ http://purl.uniprot.org/uniprot/U3JLP1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 8 family.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:MAPK9 ^@ http://purl.uniprot.org/uniprot/U3JZ19 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/59894:POLR2J ^@ http://purl.uniprot.org/uniprot/U3K4H8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the archaeal Rpo11/eukaryotic RPB11/RPC19 RNA polymerase subunit family.|||DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Component of RNA polymerase II which synthesizes mRNA precursors and many functional non-coding RNAs. Pol II is the central component of the basal RNA polymerase II transcription machinery. It is composed of mobile elements that move relative to each other. RPB11 is part of the core element with the central large cleft.|||Nucleus http://togogenome.org/gene/59894:USP13 ^@ http://purl.uniprot.org/uniprot/A0A803VS62|||http://purl.uniprot.org/uniprot/U3K0Z6 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:ARF6 ^@ http://purl.uniprot.org/uniprot/U3KJ88 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family. http://togogenome.org/gene/59894:IMPACT ^@ http://purl.uniprot.org/uniprot/U3JU81 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the IMPACT family.|||Cytoplasm http://togogenome.org/gene/59894:PDXK ^@ http://purl.uniprot.org/uniprot/U3KCQ4 ^@ Similarity ^@ Belongs to the pyridoxine kinase family. http://togogenome.org/gene/59894:STMN1 ^@ http://purl.uniprot.org/uniprot/U3JCC4 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/59894:LOC101815314 ^@ http://purl.uniprot.org/uniprot/U3JUU5 ^@ Similarity ^@ Belongs to the folate receptor family. http://togogenome.org/gene/59894:NCBP3 ^@ http://purl.uniprot.org/uniprot/U3JW44 ^@ Similarity ^@ Belongs to the NCBP3 family. http://togogenome.org/gene/59894:FAM98A ^@ http://purl.uniprot.org/uniprot/U3KC21 ^@ Similarity ^@ Belongs to the FAM98 family. http://togogenome.org/gene/59894:LOC101809744 ^@ http://purl.uniprot.org/uniprot/A0A803VPC9|||http://purl.uniprot.org/uniprot/U3K9A4 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LOC101820076 ^@ http://purl.uniprot.org/uniprot/U3JSQ2 ^@ Similarity ^@ Belongs to the PRPH2/ROM1 family. http://togogenome.org/gene/59894:POLA1 ^@ http://purl.uniprot.org/uniprot/U3JNC8 ^@ Similarity ^@ Belongs to the DNA polymerase type-B family. http://togogenome.org/gene/59894:HNF1A ^@ http://purl.uniprot.org/uniprot/U3JYI0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the HNF1 homeobox family.|||Nucleus http://togogenome.org/gene/59894:ERBB4 ^@ http://purl.uniprot.org/uniprot/A0A803WA59 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. EGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:SPRY1 ^@ http://purl.uniprot.org/uniprot/U3K0G2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sprouty family.|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:FAM161B ^@ http://purl.uniprot.org/uniprot/U3JUP9 ^@ Similarity ^@ Belongs to the FAM161 family. http://togogenome.org/gene/59894:BCO1 ^@ http://purl.uniprot.org/uniprot/U3JWF5 ^@ Similarity ^@ Belongs to the carotenoid oxygenase family. http://togogenome.org/gene/59894:LOC101811340 ^@ http://purl.uniprot.org/uniprot/U3JX90 ^@ Function|||Similarity ^@ Belongs to the phospholipid scramblase family.|||May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. http://togogenome.org/gene/59894:LOC101822253 ^@ http://purl.uniprot.org/uniprot/A0A803W0H9 ^@ Similarity ^@ Belongs to the GroES chaperonin family. http://togogenome.org/gene/59894:TMPRSS6 ^@ http://purl.uniprot.org/uniprot/U3KEP8 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:SLC5A8 ^@ http://purl.uniprot.org/uniprot/U3K9A7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.|||Membrane http://togogenome.org/gene/59894:CNTNAP4 ^@ http://purl.uniprot.org/uniprot/U3KD33 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the neurexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:PAX2 ^@ http://purl.uniprot.org/uniprot/U3JXX5 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SLC2A5 ^@ http://purl.uniprot.org/uniprot/U3JY23 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:PDCD5 ^@ http://purl.uniprot.org/uniprot/U3JBV4 ^@ Similarity ^@ Belongs to the PDCD5 family. http://togogenome.org/gene/59894:DGKE ^@ http://purl.uniprot.org/uniprot/U3JHW3 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59894:SPDYA ^@ http://purl.uniprot.org/uniprot/U3K9G7 ^@ Similarity ^@ Belongs to the Speedy/Ringo family. http://togogenome.org/gene/59894:TXNRD2 ^@ http://purl.uniprot.org/uniprot/U3K051 ^@ Cofactor|||Similarity ^@ Belongs to the class-I pyridine nucleotide-disulfide oxidoreductase family.|||Binds 1 FAD per subunit. http://togogenome.org/gene/59894:PTAFR ^@ http://purl.uniprot.org/uniprot/U3KIP6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with ARRB1.|||Membrane http://togogenome.org/gene/59894:LOC101812659 ^@ http://purl.uniprot.org/uniprot/U3JWD8 ^@ Subcellular Location Annotation ^@ Membrane|||cytoskeleton http://togogenome.org/gene/59894:RSAD1 ^@ http://purl.uniprot.org/uniprot/A0A803W937|||http://purl.uniprot.org/uniprot/U3JF25 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the anaerobic coproporphyrinogen-III oxidase family. HemW subfamily.|||May be a heme chaperone, appears to bind heme. Homologous bacterial proteins do not have oxygen-independent coproporphyrinogen-III oxidase activity. Binds 1 [4Fe-4S] cluster. The cluster is coordinated with 3 cysteines and an exchangeable S-adenosyl-L-methionine.|||Mitochondrion http://togogenome.org/gene/59894:LOC101810518 ^@ http://purl.uniprot.org/uniprot/U3K0E4 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse|||axon|||dendrite http://togogenome.org/gene/59894:CUL2 ^@ http://purl.uniprot.org/uniprot/A0A803VBM8|||http://purl.uniprot.org/uniprot/U3JX37 ^@ Similarity ^@ Belongs to the cullin family. http://togogenome.org/gene/59894:TES ^@ http://purl.uniprot.org/uniprot/U3K6A4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the prickle / espinas / testin family.|||focal adhesion http://togogenome.org/gene/59894:CRK ^@ http://purl.uniprot.org/uniprot/A0A803V939 ^@ Similarity ^@ Belongs to the CRK family. http://togogenome.org/gene/59894:IFT122 ^@ http://purl.uniprot.org/uniprot/U3KGW3 ^@ Subcellular Location Annotation ^@ cilium http://togogenome.org/gene/59894:GARS ^@ http://purl.uniprot.org/uniprot/A0A803VLP0|||http://purl.uniprot.org/uniprot/U3JVM5 ^@ Similarity|||Subunit ^@ Belongs to the class-II aminoacyl-tRNA synthetase family.|||Homodimer. http://togogenome.org/gene/59894:DMC1 ^@ http://purl.uniprot.org/uniprot/U3KDJ2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the RecA family. DMC1 subfamily.|||May participate in meiotic recombination, specifically in homologous strand assimilation, which is required for the resolution of meiotic double-strand breaks.|||Nucleus http://togogenome.org/gene/59894:LOC107604580 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:TMEM2 ^@ http://purl.uniprot.org/uniprot/U3K865 ^@ Similarity ^@ Belongs to the CEMIP family. http://togogenome.org/gene/59894:SEZ6L ^@ http://purl.uniprot.org/uniprot/U3K1H6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ND1 ^@ http://purl.uniprot.org/uniprot/S0AU83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 1 family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:LOC101817812 ^@ http://purl.uniprot.org/uniprot/U3KH76 ^@ Subunit ^@ Monomer. http://togogenome.org/gene/59894:QRFPR ^@ http://purl.uniprot.org/uniprot/U3K104 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:LOC101810308 ^@ http://purl.uniprot.org/uniprot/U3JXB7 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:GGA1 ^@ http://purl.uniprot.org/uniprot/A0A803WF14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GGA protein family.|||Early endosome membrane|||Endosome membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:MUT ^@ http://purl.uniprot.org/uniprot/U3KE18 ^@ Function|||Similarity ^@ Belongs to the methylmalonyl-CoA mutase family.|||Catalyzes the reversible isomerization of methylmalonyl-CoA (MMCoA) (generated from branched-chain amino acid metabolism and degradation of dietary odd chain fatty acids and cholesterol) to succinyl-CoA (3-carboxypropionyl-CoA), a key intermediate of the tricarboxylic acid cycle. http://togogenome.org/gene/59894:CHMP3 ^@ http://purl.uniprot.org/uniprot/A0A803W000|||http://purl.uniprot.org/uniprot/U3K6D2 ^@ Similarity ^@ Belongs to the SNF7 family. http://togogenome.org/gene/59894:CAMK2A ^@ http://purl.uniprot.org/uniprot/A0A803VCH0|||http://purl.uniprot.org/uniprot/U3JZX5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. CaMK subfamily. http://togogenome.org/gene/59894:PKD2 ^@ http://purl.uniprot.org/uniprot/U3JRG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the polycystin family.|||Cell membrane|||Membrane|||cilium membrane http://togogenome.org/gene/59894:MAP3K8 ^@ http://purl.uniprot.org/uniprot/U3JXE0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. MAP kinase kinase kinase subfamily. http://togogenome.org/gene/59894:FAM124A ^@ http://purl.uniprot.org/uniprot/U3K1A3 ^@ Similarity ^@ Belongs to the FAM124 family. http://togogenome.org/gene/59894:IQCD ^@ http://purl.uniprot.org/uniprot/U3JWP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC10 family.|||Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes.|||flagellum axoneme http://togogenome.org/gene/59894:PSMD1 ^@ http://purl.uniprot.org/uniprot/U3JYM6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the proteasome subunit S1 family.|||Component of the 19S proteasome regulatory particle complex. The 26S proteasome consists of a 20S core particle (CP) and two 19S regulatory subunits (RP).|||Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. http://togogenome.org/gene/59894:PDGFRA ^@ http://purl.uniprot.org/uniprot/U3JLD9 ^@ Activity Regulation|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Cell membrane|||Interacts with homodimeric PDGFA, PDGFB and PDGFC, and with heterodimers formed by PDGFA and PDGFB. Monomer in the absence of bound ligand.|||Membrane|||Present in an inactive conformation in the absence of bound ligand. Binding of PDGFA and/or PDGFB leads to dimerization and activation by autophosphorylation on tyrosine residues.|||Tyrosine-protein kinase that acts as a cell-surface receptor for PDGFA, PDGFB and PDGFC and plays an essential role in the regulation of embryonic development, cell proliferation, survival and chemotaxis. Depending on the context, promotes or inhibits cell proliferation and cell migration. Plays an important role in the differentiation of bone marrow-derived mesenchymal stem cells. Required for normal skeleton development. http://togogenome.org/gene/59894:LOC101813624 ^@ http://purl.uniprot.org/uniprot/U3JM97|||http://purl.uniprot.org/uniprot/U3JM98 ^@ Function ^@ Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. http://togogenome.org/gene/59894:MRPL53 ^@ http://purl.uniprot.org/uniprot/A0A803W869 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrion-specific ribosomal protein mL53 family.|||Mitochondrion http://togogenome.org/gene/59894:ITGB3 ^@ http://purl.uniprot.org/uniprot/A0A803W9U8|||http://purl.uniprot.org/uniprot/U3K062 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the integrin beta chain family.|||Membrane http://togogenome.org/gene/59894:SLC26A3 ^@ http://purl.uniprot.org/uniprot/U3K6K5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Chloride/bicarbonate exchanger.|||Membrane http://togogenome.org/gene/59894:CTSL ^@ http://purl.uniprot.org/uniprot/A0A803VMR0 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59894:WNT8A ^@ http://purl.uniprot.org/uniprot/U3JYX1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:AGTR2 ^@ http://purl.uniprot.org/uniprot/U3KJQ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Interacts with MTUS1.|||Membrane http://togogenome.org/gene/59894:BEGAIN ^@ http://purl.uniprot.org/uniprot/U3JJ65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:FAM91A1 ^@ http://purl.uniprot.org/uniprot/U3JII8 ^@ Similarity ^@ Belongs to the FAM91 family. http://togogenome.org/gene/59894:CHAT ^@ http://purl.uniprot.org/uniprot/U3JWD1 ^@ Similarity ^@ Belongs to the carnitine/choline acetyltransferase family. http://togogenome.org/gene/59894:LOC101811124 ^@ http://purl.uniprot.org/uniprot/A0A803V4S1 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2A family.|||Chromosome|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:TMEM98 ^@ http://purl.uniprot.org/uniprot/U3K4B2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM98 family.|||Endoplasmic reticulum membrane|||Membrane|||extracellular exosome http://togogenome.org/gene/59894:BEST3 ^@ http://purl.uniprot.org/uniprot/U3K6K7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the bestrophin family.|||Cell membrane|||Forms chloride channels.|||Membrane http://togogenome.org/gene/59894:SLC9A9 ^@ http://purl.uniprot.org/uniprot/U3JX83 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) family.|||Endosome membrane|||Membrane http://togogenome.org/gene/59894:KHDRBS3 ^@ http://purl.uniprot.org/uniprot/U3JJB2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the KHDRBS family.|||Cytoplasm http://togogenome.org/gene/59894:GHRH ^@ http://purl.uniprot.org/uniprot/A0A803V535 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glucagon family.|||Secreted http://togogenome.org/gene/59894:LOC101817369 ^@ http://purl.uniprot.org/uniprot/A0A803VW13 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:PDPR ^@ http://purl.uniprot.org/uniprot/U3JY72 ^@ Similarity ^@ Belongs to the GcvT family. http://togogenome.org/gene/59894:LOC101821679 ^@ http://purl.uniprot.org/uniprot/U3KHZ1 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:PCMTD2 ^@ http://purl.uniprot.org/uniprot/U3K6Z9 ^@ Similarity ^@ Belongs to the methyltransferase superfamily. L-isoaspartyl/D-aspartyl protein methyltransferase family. http://togogenome.org/gene/59894:LOC101814981 ^@ http://purl.uniprot.org/uniprot/A0A803VIG4|||http://purl.uniprot.org/uniprot/U3JY05 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protease inhibitor I39 (alpha-2-macroglobulin) family.|||Secreted http://togogenome.org/gene/59894:POLR3H ^@ http://purl.uniprot.org/uniprot/U3KBS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB7/RPC8 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/59894:DHCR7 ^@ http://purl.uniprot.org/uniprot/A0A803VJW2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ERG4/ERG24 family.|||Membrane http://togogenome.org/gene/59894:ATP6AP1L ^@ http://purl.uniprot.org/uniprot/A0A803VPR1 ^@ Similarity ^@ Belongs to the vacuolar ATPase subunit S1 family. http://togogenome.org/gene/59894:BACE1 ^@ http://purl.uniprot.org/uniprot/U3JTE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase A1 family.|||Membrane raft|||Recycling endosome|||trans-Golgi network http://togogenome.org/gene/59894:KIF13B ^@ http://purl.uniprot.org/uniprot/A0A803VDU8|||http://purl.uniprot.org/uniprot/U3K8I1 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Kinesin family. http://togogenome.org/gene/59894:SNX20 ^@ http://purl.uniprot.org/uniprot/U3JBC8 ^@ Subcellular Location Annotation ^@ Early endosome membrane|||Membrane http://togogenome.org/gene/59894:LOC101814521 ^@ http://purl.uniprot.org/uniprot/U3JMX3 ^@ Similarity ^@ Belongs to the flavoprotein pyridine nucleotide cytochrome reductase family. http://togogenome.org/gene/59894:C4H4orf48 ^@ http://purl.uniprot.org/uniprot/U3K5L1 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:LYZ ^@ http://purl.uniprot.org/uniprot/A0A803WC14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyl hydrolase 22 family.|||Secreted http://togogenome.org/gene/59894:USP37 ^@ http://purl.uniprot.org/uniprot/U3JN86 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:B9D1 ^@ http://purl.uniprot.org/uniprot/A0A803VG73|||http://purl.uniprot.org/uniprot/U3KGZ1 ^@ Subcellular Location Annotation ^@ cilium basal body http://togogenome.org/gene/59894:LOC101806066 ^@ http://purl.uniprot.org/uniprot/U3JZ87 ^@ Similarity ^@ Belongs to the DCK/DGK family. http://togogenome.org/gene/59894:NMNAT3 ^@ http://purl.uniprot.org/uniprot/A0A803V3H8|||http://purl.uniprot.org/uniprot/A0A803VPE5|||http://purl.uniprot.org/uniprot/A0A803VUC4 ^@ Similarity ^@ Belongs to the eukaryotic NMN adenylyltransferase family. http://togogenome.org/gene/59894:RCAN1 ^@ http://purl.uniprot.org/uniprot/A0A803VNE1 ^@ Similarity ^@ Belongs to the RCAN family. http://togogenome.org/gene/59894:FOXL2 ^@ http://purl.uniprot.org/uniprot/U3KL56 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:POU2F3 ^@ http://purl.uniprot.org/uniprot/U3JU14 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the POU transcription factor family. Class-2 subfamily.|||Nucleus http://togogenome.org/gene/59894:LOC101814550 ^@ http://purl.uniprot.org/uniprot/A0A803WA26 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glypican family.|||Cell membrane|||Cell surface proteoglycan that bears heparan sulfate. http://togogenome.org/gene/59894:ERO1A ^@ http://purl.uniprot.org/uniprot/U3JMP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EROs family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:CRYL1 ^@ http://purl.uniprot.org/uniprot/U3K268 ^@ Similarity ^@ Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. http://togogenome.org/gene/59894:ARRDC3 ^@ http://purl.uniprot.org/uniprot/U3K354 ^@ Similarity ^@ Belongs to the arrestin family. http://togogenome.org/gene/59894:HCRT ^@ http://purl.uniprot.org/uniprot/U3KLG6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the orexin family.|||Cytoplasmic vesicle|||Endoplasmic reticulum|||Synapse|||Vesicle http://togogenome.org/gene/59894:CDK1 ^@ http://purl.uniprot.org/uniprot/U3KFU5 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:RPL7L1 ^@ http://purl.uniprot.org/uniprot/A0A803V0A7 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL30 family. http://togogenome.org/gene/59894:ESF1 ^@ http://purl.uniprot.org/uniprot/U3K8P0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ESF1 family.|||nucleolus http://togogenome.org/gene/59894:EPB42 ^@ http://purl.uniprot.org/uniprot/U3JQT6 ^@ Similarity ^@ Belongs to the transglutaminase superfamily. Transglutaminase family. http://togogenome.org/gene/59894:LOC101814081 ^@ http://purl.uniprot.org/uniprot/A0A803VXB4 ^@ Similarity ^@ Belongs to the TMEM14 family. http://togogenome.org/gene/59894:GPN2 ^@ http://purl.uniprot.org/uniprot/U3JC23 ^@ Function|||Similarity|||Subunit ^@ Belongs to the GPN-loop GTPase family.|||Binds to RNA polymerase II (RNAPII).|||Small GTPase required for proper localization of RNA polymerase II and III (RNAPII and RNAPIII). May act at an RNAP assembly step prior to nuclear import. http://togogenome.org/gene/59894:MAGI3 ^@ http://purl.uniprot.org/uniprot/U3JDD5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAGUK family.|||Cell membrane|||Membrane|||tight junction http://togogenome.org/gene/59894:MST1 ^@ http://purl.uniprot.org/uniprot/U3K2Y8 ^@ Caution|||Similarity ^@ Belongs to the peptidase S1 family. Plasminogen subfamily.|||Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:MLF2 ^@ http://purl.uniprot.org/uniprot/U3JQ60 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MLF family.|||Cytoplasm http://togogenome.org/gene/59894:POLR2D ^@ http://purl.uniprot.org/uniprot/A0A803WB38 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eukaryotic RPB4 RNA polymerase subunit family.|||Nucleus http://togogenome.org/gene/59894:OC90 ^@ http://purl.uniprot.org/uniprot/U3JIV0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/59894:LOC107604235 ^@ http://purl.uniprot.org/uniprot/A0A803VNM5 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:ST6GALNAC6 ^@ http://purl.uniprot.org/uniprot/U3JF16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:EBF1 ^@ http://purl.uniprot.org/uniprot/A0A803V2L1|||http://purl.uniprot.org/uniprot/U3K1F9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COE family.|||Nucleus http://togogenome.org/gene/59894:ATG13 ^@ http://purl.uniprot.org/uniprot/A0A803V5B5|||http://purl.uniprot.org/uniprot/U3JUS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATG13 family. Metazoan subfamily.|||Preautophagosomal structure http://togogenome.org/gene/59894:ELF2 ^@ http://purl.uniprot.org/uniprot/U3JQL8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ETS family.|||Nucleus http://togogenome.org/gene/59894:PLA2G1B ^@ http://purl.uniprot.org/uniprot/U3JYR0 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the phospholipase A2 family.|||Binds 1 Ca(2+) ion per subunit.|||Secreted http://togogenome.org/gene/59894:TRAPPC4 ^@ http://purl.uniprot.org/uniprot/A0A803VVJ6 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the TRAPP small subunits family.|||Endoplasmic reticulum|||Part of the multisubunit transport protein particle (TRAPP) complex.|||cis-Golgi network http://togogenome.org/gene/59894:PAX9 ^@ http://purl.uniprot.org/uniprot/U3JUG2 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:KDM4C ^@ http://purl.uniprot.org/uniprot/U3K7V0 ^@ Similarity ^@ Belongs to the JHDM3 histone demethylase family. http://togogenome.org/gene/59894:PDE4C ^@ http://purl.uniprot.org/uniprot/U3JF37 ^@ Cofactor|||Similarity ^@ Belongs to the cyclic nucleotide phosphodiesterase family. PDE4 subfamily.|||Binds 2 divalent metal cations per subunit. Site 1 may preferentially bind zinc ions, while site 2 has a preference for magnesium and/or manganese ions. http://togogenome.org/gene/59894:LOC101811337 ^@ http://purl.uniprot.org/uniprot/U3JP31 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:ATP6 ^@ http://purl.uniprot.org/uniprot/S0AU85 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ATPase A chain family.|||Membrane|||Mitochondrial membrane ATP synthase (F(1)F(0) ATP synthase or Complex V) produces ATP from ADP in the presence of a proton gradient across the membrane which is generated by electron transport complexes of the respiratory chain. F-type ATPases consist of two structural domains, F(1) - containing the extramembraneous catalytic core and F(0) - containing the membrane proton channel, linked together by a central stalk and a peripheral stalk. During catalysis, ATP synthesis in the catalytic domain of F(1) is coupled via a rotary mechanism of the central stalk subunits to proton translocation. Key component of the proton channel; it may play a direct role in the translocation of protons across the membrane.|||Mitochondrion inner membrane http://togogenome.org/gene/59894:UGDH ^@ http://purl.uniprot.org/uniprot/U3K3N1 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDP-glucose/GDP-mannose dehydrogenase family.|||Homohexamer.|||Involved in the biosynthesis of glycosaminoglycans; hyaluronan, chondroitin sulfate, and heparan sulfate. http://togogenome.org/gene/59894:ABCG5 ^@ http://purl.uniprot.org/uniprot/U3KE22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/59894:KATNB1 ^@ http://purl.uniprot.org/uniprot/U3JWQ4 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the WD repeat KATNB1 family.|||Cytoplasm|||Interacts with KATNA1. This interaction enhances the microtubule binding and severing activity of KATNA1 and also targets this activity to the centrosome.|||Participates in a complex which severs microtubules in an ATP-dependent manner. May act to target the enzymatic subunit of this complex to sites of action such as the centrosome. Microtubule severing may promote rapid reorganization of cellular microtubule arrays and the release of microtubules from the centrosome following nucleation.|||centrosome|||cytoskeleton|||spindle|||spindle pole http://togogenome.org/gene/59894:PSMA4 ^@ http://purl.uniprot.org/uniprot/A0A803VQU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase T1A family.|||Component of the 20S core proteasome complex involved in the proteolytic degradation of most intracellular proteins. This complex plays numerous essential roles within the cell by associating with different regulatory particles. Associated with two 19S regulatory particles, forms the 26S proteasome and thus participates in the ATP-dependent degradation of ubiquitinated proteins. The 26S proteasome plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins that could impair cellular functions, and by removing proteins whose functions are no longer required. Associated with the PA200 or PA28, the 20S proteasome mediates ubiquitin-independent protein degradation. This type of proteolysis is required in several pathways including spermatogenesis (20S-PA200 complex) or generation of a subset of MHC class I-presented antigenic peptides (20S-PA28 complex).|||Cytoplasm|||Nucleus|||The 26S proteasome consists of a 20S proteasome core and two 19S regulatory subunits. http://togogenome.org/gene/59894:PLA2G4F ^@ http://purl.uniprot.org/uniprot/U3JTL6 ^@ Domain|||Subcellular Location Annotation ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding.|||cytosol http://togogenome.org/gene/59894:LOC101811311 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:SOD1 ^@ http://purl.uniprot.org/uniprot/U3K088 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the Cu-Zn superoxide dismutase family.|||Binds 1 copper ion per subunit.|||Binds 1 zinc ion per subunit.|||Destroys radicals which are normally produced within the cells and which are toxic to biological systems. http://togogenome.org/gene/59894:EMX2 ^@ http://purl.uniprot.org/uniprot/A0A803VIJ3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CTSZ ^@ http://purl.uniprot.org/uniprot/A0A803VT50 ^@ Similarity ^@ Belongs to the peptidase C1 family. http://togogenome.org/gene/59894:SLC25A30 ^@ http://purl.uniprot.org/uniprot/A0A803VW92|||http://purl.uniprot.org/uniprot/U3K0H6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:LOC101820822 ^@ http://purl.uniprot.org/uniprot/U3K091 ^@ Similarity ^@ Belongs to the small heat shock protein (HSP20) family. http://togogenome.org/gene/59894:LOC101810494 ^@ http://purl.uniprot.org/uniprot/U3JS14 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/59894:RNASEH1 ^@ http://purl.uniprot.org/uniprot/A0A803WFL2 ^@ Function|||Similarity ^@ Belongs to the RNase H family.|||Endonuclease that specifically degrades the RNA of RNA-DNA hybrids. http://togogenome.org/gene/59894:LOC101812686 ^@ http://purl.uniprot.org/uniprot/U3JQZ5 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:DHX30 ^@ http://purl.uniprot.org/uniprot/A0A803VUH3|||http://purl.uniprot.org/uniprot/U3JH43 ^@ Similarity ^@ Belongs to the DEAD box helicase family. DEAH subfamily. http://togogenome.org/gene/59894:PPFIBP1 ^@ http://purl.uniprot.org/uniprot/A0A803V6H5|||http://purl.uniprot.org/uniprot/A0A803VXI8|||http://purl.uniprot.org/uniprot/U3JMW7 ^@ Similarity ^@ Belongs to the liprin family. Liprin-beta subfamily. http://togogenome.org/gene/59894:FSHR ^@ http://purl.uniprot.org/uniprot/A0A803V4M8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||G protein-coupled receptor for follitropin, the follicle-stimulating hormone. Through cAMP production activates the downstream PI3K-AKT and ERK1/ERK2 signaling pathways.|||Membrane http://togogenome.org/gene/59894:NUDCD1 ^@ http://purl.uniprot.org/uniprot/A0A803WAN5|||http://purl.uniprot.org/uniprot/U3JUC9 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:PHC1 ^@ http://purl.uniprot.org/uniprot/U3JY21 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:DUSP27 ^@ http://purl.uniprot.org/uniprot/U3JFR5 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class dual specificity subfamily. http://togogenome.org/gene/59894:GDPD2 ^@ http://purl.uniprot.org/uniprot/U3KC25 ^@ Similarity ^@ Belongs to the glycerophosphoryl diester phosphodiesterase family. http://togogenome.org/gene/59894:AQP4 ^@ http://purl.uniprot.org/uniprot/U3JU44 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MIP/aquaporin (TC 1.A.8) family.|||Membrane http://togogenome.org/gene/59894:DPM1 ^@ http://purl.uniprot.org/uniprot/U3KF01 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyltransferase 2 family.|||Component of the dolichol-phosphate mannose (DPM) synthase complex.|||Endoplasmic reticulum|||Transfers mannose from GDP-mannose to dolichol monophosphate to form dolichol phosphate mannose (Dol-P-Man) which is the mannosyl donor in pathways leading to N-glycosylation, glycosyl phosphatidylinositol membrane anchoring, and O-mannosylation of proteins; catalytic subunit of the dolichol-phosphate mannose (DPM) synthase complex. http://togogenome.org/gene/59894:ZDHHC14 ^@ http://purl.uniprot.org/uniprot/U3KDJ7 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family.|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:LOC101812606 ^@ http://purl.uniprot.org/uniprot/U3JP95 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:TACR3 ^@ http://purl.uniprot.org/uniprot/U3K0M9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:CREB1 ^@ http://purl.uniprot.org/uniprot/A0A803VJN6|||http://purl.uniprot.org/uniprot/U3JN11 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SLC26A9 ^@ http://purl.uniprot.org/uniprot/U3JCV5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||DIDS- and thiosulfate- sensitive anion exchanger mediating chloride, sulfate and oxalate transport.|||Membrane http://togogenome.org/gene/59894:SSRP1 ^@ http://purl.uniprot.org/uniprot/U3K9Q7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SSRP1 family.|||Chromosome|||Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment of the nucleosome following the passage of RNA polymerase II.|||Nucleus http://togogenome.org/gene/59894:MED10 ^@ http://purl.uniprot.org/uniprot/U3JXL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the Mediator complex subunit 10 family.|||Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene-specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors.|||Component of the Mediator complex.|||Nucleus http://togogenome.org/gene/59894:PRKAR1B ^@ http://purl.uniprot.org/uniprot/A0A803VYS0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cAMP-dependent kinase regulatory chain family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:RPL30 ^@ http://purl.uniprot.org/uniprot/U3JT35 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eL30 family. http://togogenome.org/gene/59894:DOLK ^@ http://purl.uniprot.org/uniprot/U3KLH9 ^@ Similarity ^@ Belongs to the polyprenol kinase family. http://togogenome.org/gene/59894:DBH ^@ http://purl.uniprot.org/uniprot/U3JFU1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the copper type II ascorbate-dependent monooxygenase family.|||Conversion of dopamine to noradrenaline.|||Homotetramer; composed of two disulfide-linked dimers.|||chromaffin granule lumen|||chromaffin granule membrane|||secretory vesicle lumen|||secretory vesicle membrane http://togogenome.org/gene/59894:ZFHX4 ^@ http://purl.uniprot.org/uniprot/A0A803VYC2|||http://purl.uniprot.org/uniprot/U3K1P8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:PPRC1 ^@ http://purl.uniprot.org/uniprot/U3K1E6 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SEPT7 ^@ http://purl.uniprot.org/uniprot/U3JJD7|||http://purl.uniprot.org/uniprot/U3JJE0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. Septin GTPase family.|||Cleavage furrow|||Midbody|||cilium axoneme|||kinetochore|||spindle http://togogenome.org/gene/59894:ADGRG2 ^@ http://purl.uniprot.org/uniprot/U3JNV7 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:HOMER1 ^@ http://purl.uniprot.org/uniprot/U3K5M7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Homer family.|||Cytoplasm|||Postsynaptic density|||Synapse http://togogenome.org/gene/59894:ADD1 ^@ http://purl.uniprot.org/uniprot/A0A803VAQ2 ^@ Similarity ^@ Belongs to the aldolase class II family. Adducin subfamily. http://togogenome.org/gene/59894:MRPS10 ^@ http://purl.uniprot.org/uniprot/A0A803VRU0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uS10 family.|||Mitochondrion http://togogenome.org/gene/59894:OSGEPL1 ^@ http://purl.uniprot.org/uniprot/U3JP94 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the KAE1 / TsaD family.|||Binds 1 divalent metal cation per subunit.|||Mitochondrion|||Monomer.|||Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in mitochondrial tRNAs that read codons beginning with adenine. Probably involved in the transfer of the threonylcarbamoyl moiety of threonylcarbamoyl-AMP (TC-AMP) to the N6 group of A37. Involved in mitochondrial genome maintenance. http://togogenome.org/gene/59894:RPS6KA2 ^@ http://purl.uniprot.org/uniprot/A0A803W3D0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. S6 kinase subfamily. http://togogenome.org/gene/59894:AOX1 ^@ http://purl.uniprot.org/uniprot/U3JNN8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the xanthine dehydrogenase family.|||Binds 1 Mo-molybdopterin (Mo-MPT) cofactor per subunit.|||Binds 2 [2Fe-2S] clusters.|||Cytoplasm|||Homodimer. http://togogenome.org/gene/59894:LOC101812163 ^@ http://purl.uniprot.org/uniprot/U3KBU3 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DDX51 ^@ http://purl.uniprot.org/uniprot/U3JXN4 ^@ Similarity ^@ Belongs to the DEAD box helicase family. http://togogenome.org/gene/59894:F2R ^@ http://purl.uniprot.org/uniprot/U3K607 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:MGST1 ^@ http://purl.uniprot.org/uniprot/A0A803WDJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the MAPEG family.|||Membrane http://togogenome.org/gene/59894:SCN3B ^@ http://purl.uniprot.org/uniprot/U3JT96 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium channel auxiliary subunit SCN3B (TC 8.A.17) family.|||Membrane|||Modulates channel gating kinetics. Causes unique persistent sodium currents. Inactivates the sodium channel opening more slowly than the subunit beta-1. Its association with NFASC may target the sodium channels to the nodes of Ranvier of developing axons and retain these channels at the nodes in mature myelinated axons. http://togogenome.org/gene/59894:SEMA5A ^@ http://purl.uniprot.org/uniprot/U3JZG8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ATE1 ^@ http://purl.uniprot.org/uniprot/U3JHH9 ^@ Function|||Similarity ^@ Belongs to the R-transferase family.|||Involved in the post-translational conjugation of arginine to the N-terminal aspartate or glutamate of a protein. This arginylation is required for degradation of the protein via the ubiquitin pathway. http://togogenome.org/gene/59894:FCF1 ^@ http://purl.uniprot.org/uniprot/U3JUW7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the UTP23/FCF1 family. FCF1 subfamily.|||nucleolus http://togogenome.org/gene/59894:E2F4 ^@ http://purl.uniprot.org/uniprot/U3JX79 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the E2F/DP family.|||Nucleus http://togogenome.org/gene/59894:ADAMTS19 ^@ http://purl.uniprot.org/uniprot/U3JQM0 ^@ Caution|||Cofactor|||Subcellular Location Annotation ^@ Binds 1 zinc ion per subunit.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||extracellular matrix http://togogenome.org/gene/59894:GRK5 ^@ http://purl.uniprot.org/uniprot/U3JHM0 ^@ Similarity ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. GPRK subfamily. http://togogenome.org/gene/59894:RAMP1 ^@ http://purl.uniprot.org/uniprot/A0A803V565 ^@ Similarity ^@ Belongs to the RAMP family. http://togogenome.org/gene/59894:LMX1A ^@ http://purl.uniprot.org/uniprot/U3JZR7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:TNFRSF8 ^@ http://purl.uniprot.org/uniprot/U3K5X7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:MOV10 ^@ http://purl.uniprot.org/uniprot/U3JDA1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DNA2/NAM7 helicase family. SDE3 subfamily.|||P-body http://togogenome.org/gene/59894:STXBP1 ^@ http://purl.uniprot.org/uniprot/U3JSD4|||http://purl.uniprot.org/uniprot/U3JSE2 ^@ Similarity ^@ Belongs to the STXBP/unc-18/SEC1 family. http://togogenome.org/gene/59894:SERINC3 ^@ http://purl.uniprot.org/uniprot/U3JRW0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/59894:AGT ^@ http://purl.uniprot.org/uniprot/U3JL95 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the serpin family.|||Essential component of the renin-angiotensin system (RAS), a potent regulator of blood pressure, body fluid and electrolyte homeostasis.|||Secreted|||Stimulates aldosterone release. http://togogenome.org/gene/59894:SMC3 ^@ http://purl.uniprot.org/uniprot/U3JHZ0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SMC family. SMC3 subfamily.|||Central component of cohesin, a complex required for chromosome cohesion during the cell cycle. The cohesin complex may form a large proteinaceous ring within which sister chromatids can be trapped. At anaphase, the complex is cleaved and dissociates from chromatin, allowing sister chromatids to segregate. Cohesion is coupled to DNA replication and is involved in DNA repair. The cohesin complex also plays an important role in spindle pole assembly during mitosis and in chromosomes movement.|||Nucleus|||centromere http://togogenome.org/gene/59894:SCNN1B ^@ http://purl.uniprot.org/uniprot/U3KI21 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:UBA6 ^@ http://purl.uniprot.org/uniprot/U3JVS9 ^@ Similarity ^@ Belongs to the ubiquitin-activating E1 family. http://togogenome.org/gene/59894:ATF7IP ^@ http://purl.uniprot.org/uniprot/U3KAD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101817565 ^@ http://purl.uniprot.org/uniprot/U3KI83 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:SUB1 ^@ http://purl.uniprot.org/uniprot/U3JHH4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the transcriptional coactivator PC4 family.|||General coactivator that functions cooperatively with TAFs and mediates functional interactions between upstream activators and the general transcriptional machinery. May be involved in stabilizing the multiprotein transcription complex. Binds single-stranded DNA. Also binds, in vitro, non-specifically to double-stranded DNA (ds DNA).|||Nucleus http://togogenome.org/gene/59894:PLAGL1 ^@ http://purl.uniprot.org/uniprot/A0A803VLF4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:SLC35F4 ^@ http://purl.uniprot.org/uniprot/U3JLW8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC35F solute transporter family.|||Membrane http://togogenome.org/gene/59894:LOC101819238 ^@ http://purl.uniprot.org/uniprot/U3JG41 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family.|||Membrane|||Retinol dehydrogenase with a clear preference for NADP. Converts all-trans-retinal to all-trans-retinol. May play a role in the regeneration of visual pigment at high light intensity. http://togogenome.org/gene/59894:LOC101820830 ^@ http://purl.uniprot.org/uniprot/U3JYN8 ^@ Similarity ^@ Belongs to the TRIAP1/MDM35 family. http://togogenome.org/gene/59894:XPNPEP1 ^@ http://purl.uniprot.org/uniprot/A0A803V187|||http://purl.uniprot.org/uniprot/U3JI13 ^@ Similarity ^@ Belongs to the peptidase M24B family. http://togogenome.org/gene/59894:BICC1 ^@ http://purl.uniprot.org/uniprot/U3JHT5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the BicC family.|||Cytoplasm http://togogenome.org/gene/59894:SAR1B ^@ http://purl.uniprot.org/uniprot/U3JZS1 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Arf family.|||Belongs to the small GTPase superfamily. SAR1 family. http://togogenome.org/gene/59894:MDH1B ^@ http://purl.uniprot.org/uniprot/U3JMW8 ^@ Similarity ^@ Belongs to the LDH/MDH superfamily. MDH type 2 family. http://togogenome.org/gene/59894:TMEM184B ^@ http://purl.uniprot.org/uniprot/U3KDQ2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:WNT3 ^@ http://purl.uniprot.org/uniprot/A0A803WDM5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:GRID1 ^@ http://purl.uniprot.org/uniprot/U3JVW5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glutamate-gated ion channel (TC 1.A.10.1) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Receptor for glutamate that functions as a ligand-gated ion channel in the central nervous system and plays an important role in excitatory synaptic transmission. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. http://togogenome.org/gene/59894:MYO19 ^@ http://purl.uniprot.org/uniprot/U3JS10 ^@ Similarity ^@ Belongs to the TRAFAC class myosin-kinesin ATPase superfamily. Myosin family. http://togogenome.org/gene/59894:HDAC1 ^@ http://purl.uniprot.org/uniprot/U3JD04 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the histone deacetylase family. HD Type 1 subfamily.|||Histone deacetylase that catalyzes the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also functions as deacetylase for non-histone proteins.|||Nucleus http://togogenome.org/gene/59894:LOC101821578 ^@ http://purl.uniprot.org/uniprot/U3K6R1 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Vasopressin/oxytocin receptor subfamily.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:TRMT61A ^@ http://purl.uniprot.org/uniprot/U3JJL9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. TRM61 family.|||Catalytic subunit of tRNA (adenine-N(1)-)-methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA.|||Nucleus http://togogenome.org/gene/59894:DLC1 ^@ http://purl.uniprot.org/uniprot/U3JM73 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ Cytoplasm|||Functions as a GTPase-activating protein for the small GTPases RHOA, RHOB, RHOC and CDC42, terminating their downstream signaling. This induces morphological changes and detachment through cytoskeletal reorganization, playing a critical role in biological processes such as cell migration and proliferation. Also functions in vivo as an activator of the phospholipase PLCD1. Active DLC1 increases cell migration velocity but reduces directionality.|||Interacts with EF1A1, facilitates EF1A1 distribution to the membrane periphery and ruffles upon growth factor stimulation and suppresses cell migration.|||Membrane|||focal adhesion http://togogenome.org/gene/59894:IDH2 ^@ http://purl.uniprot.org/uniprot/U3K921 ^@ Cofactor|||Similarity ^@ Belongs to the isocitrate and isopropylmalate dehydrogenases family.|||Binds 1 Mg(2+) or Mn(2+) ion per subunit. http://togogenome.org/gene/59894:MDFIC ^@ http://purl.uniprot.org/uniprot/A0A803W8N8|||http://purl.uniprot.org/uniprot/U3K6B9 ^@ Similarity ^@ Belongs to the MDFI family. http://togogenome.org/gene/59894:LBH ^@ http://purl.uniprot.org/uniprot/A0A803VH06 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the LBH family.|||Cytoplasm|||Nucleus|||Transcriptional activator. http://togogenome.org/gene/59894:HACE1 ^@ http://purl.uniprot.org/uniprot/U3KAM2 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:OLFM1 ^@ http://purl.uniprot.org/uniprot/U3JG48|||http://purl.uniprot.org/uniprot/U3JG49 ^@ Subcellular Location Annotation ^@ Secreted|||Synapse http://togogenome.org/gene/59894:MAGT1 ^@ http://purl.uniprot.org/uniprot/A0A803VZ70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the OST3/OST6 family.|||Cell membrane|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:NKIRAS2 ^@ http://purl.uniprot.org/uniprot/A0A803VEW6 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. KappaB-Ras subfamily. http://togogenome.org/gene/59894:FOXP1 ^@ http://purl.uniprot.org/uniprot/U3KG46 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:UGP2 ^@ http://purl.uniprot.org/uniprot/U3KGN6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the UDPGP type 1 family.|||Homooctamer.|||UTP--glucose-1-phosphate uridylyltransferase catalyzing the conversion of glucose-1-phosphate into UDP-glucose, a crucial precursor for the production of glycogen. http://togogenome.org/gene/59894:SVIL ^@ http://purl.uniprot.org/uniprot/A0A803W1S9 ^@ Similarity ^@ Belongs to the villin/gelsolin family. http://togogenome.org/gene/59894:EFHC1 ^@ http://purl.uniprot.org/uniprot/U3JHC9 ^@ Subcellular Location Annotation ^@ cilium axoneme http://togogenome.org/gene/59894:FAM46A ^@ http://purl.uniprot.org/uniprot/U3JJ39 ^@ Similarity ^@ Belongs to the TENT family. http://togogenome.org/gene/59894:LPAR1 ^@ http://purl.uniprot.org/uniprot/U3JBU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Cell surface|||Endosome|||Membrane http://togogenome.org/gene/59894:ADCY7 ^@ http://purl.uniprot.org/uniprot/U3JBD6 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the adenylyl cyclase class-4/guanylyl cyclase family.|||Binds 2 magnesium ions per subunit. Is also active with manganese (in vitro).|||Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling.|||Membrane http://togogenome.org/gene/59894:LOC101810921 ^@ http://purl.uniprot.org/uniprot/U3KKH1 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H4 family.|||Chromosome|||Core component of nucleosome. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:B4GALT2 ^@ http://purl.uniprot.org/uniprot/U3JRX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 7 family.|||Golgi apparatus membrane|||Membrane|||Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. http://togogenome.org/gene/59894:OSBPL11 ^@ http://purl.uniprot.org/uniprot/U3KGG6 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:EXOC5 ^@ http://purl.uniprot.org/uniprot/U3JM48 ^@ Function|||Similarity ^@ Belongs to the SEC10 family.|||Component of the exocyst complex involved in the docking of exocytic vesicles with fusion sites on the plasma membrane. http://togogenome.org/gene/59894:LOC101810982 ^@ http://purl.uniprot.org/uniprot/A0A803VMU9 ^@ Similarity ^@ Belongs to the D-isomer specific 2-hydroxyacid dehydrogenase family. http://togogenome.org/gene/59894:FAP ^@ http://purl.uniprot.org/uniprot/U3JD75 ^@ Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the peptidase S9B family. DPPIV subfamily.|||Cell junction|||Cell membrane|||Membrane raft|||invadopodium membrane|||lamellipodium membrane http://togogenome.org/gene/59894:FABP2 ^@ http://purl.uniprot.org/uniprot/U3JDR3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm http://togogenome.org/gene/59894:RPA1 ^@ http://purl.uniprot.org/uniprot/U3JVR7 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ As part of the heterotrimeric replication protein A complex (RPA/RP-A), binds and stabilizes single-stranded DNA intermediates, that form during DNA replication or upon DNA stress. It prevents their reannealing and in parallel, recruits and activates different proteins and complexes involved in DNA metabolism. Thereby, it plays an essential role both in DNA replication and the cellular response to DNA damage.|||Belongs to the replication factor A protein 1 family.|||Component of the heterotrimeric canonical replication protein A complex (RPA).|||PML body http://togogenome.org/gene/59894:THYN1 ^@ http://purl.uniprot.org/uniprot/U3JT00 ^@ Function ^@ Specifically binds 5-hydroxymethylcytosine (5hmC), suggesting that it acts as a specific reader of 5hmC. http://togogenome.org/gene/59894:NPLOC4 ^@ http://purl.uniprot.org/uniprot/U3KDX6 ^@ Similarity ^@ Belongs to the NPL4 family. http://togogenome.org/gene/59894:GAPDH ^@ http://purl.uniprot.org/uniprot/A0A803W110 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glyceraldehyde-3-phosphate dehydrogenase family.|||Has both glyceraldehyde-3-phosphate dehydrogenase and nitrosylase activities, thereby playing a role in glycolysis and nuclear functions, respectively. Glyceraldehyde-3-phosphate dehydrogenase is a key enzyme in glycolysis that catalyzes the first step of the pathway by converting D-glyceraldehyde 3-phosphate (G3P) into 3-phospho-D-glyceroyl phosphate (By similarity). Participates in nuclear events including transcription, RNA transport, DNA replication and apoptosis. Nuclear functions are probably due to the nitrosylase activity that mediates cysteine S-nitrosylation of nuclear target proteins such as SIRT1, HDAC2 and PRKDC.|||Homotetramer.|||cytosol http://togogenome.org/gene/59894:EIF2B5 ^@ http://purl.uniprot.org/uniprot/U3JZR1 ^@ Similarity ^@ Belongs to the eIF-2B gamma/epsilon subunits family. http://togogenome.org/gene/59894:CPLX1 ^@ http://purl.uniprot.org/uniprot/U3JE42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59894:SEC24C ^@ http://purl.uniprot.org/uniprot/A0A803WFX8|||http://purl.uniprot.org/uniprot/U3JX89 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC23/SEC24 family. SEC24 subfamily.|||COPII-coated vesicle membrane|||Endoplasmic reticulum membrane|||Membrane|||cytosol http://togogenome.org/gene/59894:PPP1R16B ^@ http://purl.uniprot.org/uniprot/U3JSZ8 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:TACC3 ^@ http://purl.uniprot.org/uniprot/U3K5V6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TACC family.|||Cytoplasm http://togogenome.org/gene/59894:BCLAF1 ^@ http://purl.uniprot.org/uniprot/A0A803VQK4|||http://purl.uniprot.org/uniprot/U3KEN9 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/59894:LOC101809980 ^@ http://purl.uniprot.org/uniprot/U3JIK3 ^@ Similarity ^@ Belongs to the serpin family. http://togogenome.org/gene/59894:RPS7 ^@ http://purl.uniprot.org/uniprot/A0A803W540 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS7 family. http://togogenome.org/gene/59894:VPS37C ^@ http://purl.uniprot.org/uniprot/U3KC14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS37 family.|||Component of the ESCRT-I complex, a regulator of vesicular trafficking process. Required for the sorting of endocytic ubiquitinated cargos into multivesicular bodies. May be involved in cell growth and differentiation.|||Endosome membrane|||Late endosome membrane http://togogenome.org/gene/59894:TMC7 ^@ http://purl.uniprot.org/uniprot/U3KI01 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TMC family.|||Membrane http://togogenome.org/gene/59894:HACD2 ^@ http://purl.uniprot.org/uniprot/A0A803VGE7 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the very long-chain fatty acids dehydratase HACD family.|||Catalyzes the third of the four reactions of the long-chain fatty acids elongation cycle. This endoplasmic reticulum-bound enzymatic process, allows the addition of two carbons to the chain of long- and very long-chain fatty acids/VLCFAs per cycle. This enzyme catalyzes the dehydration of the 3-hydroxyacyl-CoA intermediate into trans-2,3-enoyl-CoA, within each cycle of fatty acid elongation. Thereby, it participates to the production of VLCFAs of different chain lengths that are involved in multiple biological processes as precursors of membrane lipids and lipid mediators.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:ATL2 ^@ http://purl.uniprot.org/uniprot/U3JI43 ^@ Similarity ^@ Belongs to the TRAFAC class dynamin-like GTPase superfamily. GB1/RHD3 GTPase family. http://togogenome.org/gene/59894:LOC101811103 ^@ http://purl.uniprot.org/uniprot/U3KG79 ^@ Similarity ^@ Belongs to the globin family. http://togogenome.org/gene/59894:GABRA2 ^@ http://purl.uniprot.org/uniprot/U3JJY8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family. Gamma-aminobutyric acid receptor (TC 1.A.9.5) subfamily. GABRA2 sub-subfamily.|||Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane|||dendrite http://togogenome.org/gene/59894:SEMA3C ^@ http://purl.uniprot.org/uniprot/A0A803V955|||http://purl.uniprot.org/uniprot/U3K7F6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the semaphorin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Secreted http://togogenome.org/gene/59894:CA9 ^@ http://purl.uniprot.org/uniprot/U3JHK9 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:SLC6A4 ^@ http://purl.uniprot.org/uniprot/U3JUM8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family. SLC6A4 subfamily.|||Cell membrane|||Endomembrane system|||Endosome membrane|||Membrane|||Serotonin transporter whose primary function in the central nervous system involves the regulation of serotonergic signaling via transport of serotonin molecules from the synaptic cleft back into the pre-synaptic terminal for re-utilization. Plays a key role in mediating regulation of the availability of serotonin to other receptors of serotonergic systems. Terminates the action of serotonin and recycles it in a sodium-dependent manner.|||Synapse|||focal adhesion http://togogenome.org/gene/59894:PPP2R4 ^@ http://purl.uniprot.org/uniprot/U3JFD8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PTPA-type PPIase family.|||Cytoplasm|||PPIases accelerate the folding of proteins. It catalyzes the cis-trans isomerization of proline imidic peptide bonds in oligopeptides. http://togogenome.org/gene/59894:C2H8orf37 ^@ http://purl.uniprot.org/uniprot/A0A803VR57|||http://purl.uniprot.org/uniprot/U3JSU8 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in photoreceptor outer segment disk morphogenesis.|||Photoreceptor inner segment http://togogenome.org/gene/59894:CETP ^@ http://purl.uniprot.org/uniprot/A0A803VVF5|||http://purl.uniprot.org/uniprot/U3JWX3 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the BPI/LBP/Plunc superfamily. BPI/LBP family.|||Involved in the transfer of neutral lipids, including cholesteryl ester and triglyceride, among lipoprotein particles. Allows the net movement of cholesteryl ester from high density lipoproteins/HDL to triglyceride-rich very low density lipoproteins/VLDL, and the equimolar transport of triglyceride from VLDL to HDL.|||Secreted http://togogenome.org/gene/59894:TACSTD2 ^@ http://purl.uniprot.org/uniprot/U3KL08 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the EPCAM family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:RC3H2 ^@ http://purl.uniprot.org/uniprot/A0A803VTC0|||http://purl.uniprot.org/uniprot/U3JH35 ^@ Subcellular Location Annotation ^@ P-body http://togogenome.org/gene/59894:TNFRSF21 ^@ http://purl.uniprot.org/uniprot/U3JFT3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:THPO ^@ http://purl.uniprot.org/uniprot/U3K0G1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the EPO/TPO family.|||Secreted http://togogenome.org/gene/59894:MED23 ^@ http://purl.uniprot.org/uniprot/A0A803VPZ3|||http://purl.uniprot.org/uniprot/U3KB27 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Mediator complex subunit 23 family.|||Nucleus http://togogenome.org/gene/59894:LOC101814258 ^@ http://purl.uniprot.org/uniprot/U3JLL6 ^@ Similarity ^@ Belongs to the FBPase class 1 family. http://togogenome.org/gene/59894:JAK1 ^@ http://purl.uniprot.org/uniprot/U3KDU1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. JAK subfamily. http://togogenome.org/gene/59894:SLC10A7 ^@ http://purl.uniprot.org/uniprot/U3JSF6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Golgi apparatus membrane http://togogenome.org/gene/59894:NAALADL2 ^@ http://purl.uniprot.org/uniprot/U3K178 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M28 family. M28B subfamily.|||Membrane http://togogenome.org/gene/59894:LDB3 ^@ http://purl.uniprot.org/uniprot/A0A803UZY0|||http://purl.uniprot.org/uniprot/A0A803V3A3|||http://purl.uniprot.org/uniprot/A0A803VHJ2|||http://purl.uniprot.org/uniprot/A0A803VMC7 ^@ Subcellular Location Annotation ^@ Z line http://togogenome.org/gene/59894:ZNF592 ^@ http://purl.uniprot.org/uniprot/U3K5N5 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the krueppel C2H2-type zinc-finger protein family.|||May be involved in transcriptional regulation.|||Nucleus http://togogenome.org/gene/59894:SLC7A5 ^@ http://purl.uniprot.org/uniprot/A0A803WAR7|||http://purl.uniprot.org/uniprot/U3JVN8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. L-type amino acid transporter (LAT) (TC 2.A.3.8) family.|||Membrane http://togogenome.org/gene/59894:COG7 ^@ http://purl.uniprot.org/uniprot/U3KI20 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the COG7 family.|||Golgi apparatus membrane|||Membrane http://togogenome.org/gene/59894:MSTN ^@ http://purl.uniprot.org/uniprot/U3JP74 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts specifically as a negative regulator of skeletal muscle growth.|||Belongs to the TGF-beta family.|||Homodimer; disulfide-linked.|||Secreted http://togogenome.org/gene/59894:B3GNT2 ^@ http://purl.uniprot.org/uniprot/U3KIA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 31 family.|||Membrane http://togogenome.org/gene/59894:BRPF1 ^@ http://purl.uniprot.org/uniprot/U3KEJ4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CNDP2 ^@ http://purl.uniprot.org/uniprot/U3JPY9 ^@ Cofactor|||Similarity ^@ Belongs to the peptidase M20A family.|||Binds 2 manganese ions per subunit. http://togogenome.org/gene/59894:AK3 ^@ http://purl.uniprot.org/uniprot/U3K7J8 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the adenylate kinase family. AK3 subfamily.|||Consists of three domains, a large central CORE domain and two small peripheral domains, NMPbind and LID, which undergo movements during catalysis. The LID domain closes over the site of phosphoryl transfer upon GTP binding. Assembling and dissambling the active center during each catalytic cycle provides an effective means to prevent GTP hydrolysis.|||Involved in maintaining the homeostasis of cellular nucleotides by catalyzing the interconversion of nucleoside phosphates. Has GTP:AMP phosphotransferase and ITP:AMP phosphotransferase activities.|||Mitochondrion matrix|||Monomer. http://togogenome.org/gene/59894:CASK ^@ http://purl.uniprot.org/uniprot/A0A803VA48|||http://purl.uniprot.org/uniprot/A0A803VHI9|||http://purl.uniprot.org/uniprot/U3JFN2 ^@ Similarity ^@ Belongs to the MAGUK family. http://togogenome.org/gene/59894:CDK7 ^@ http://purl.uniprot.org/uniprot/U3K5J1 ^@ Similarity ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. CDC2/CDKX subfamily. http://togogenome.org/gene/59894:KCNJ1 ^@ http://purl.uniprot.org/uniprot/U3KKM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inward rectifier-type potassium channel (TC 1.A.2.1) family.|||Membrane http://togogenome.org/gene/59894:INTS10 ^@ http://purl.uniprot.org/uniprot/U3JVM8|||http://purl.uniprot.org/uniprot/U3JVN0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Integrator subunit 10 family.|||Nucleus http://togogenome.org/gene/59894:DICER1 ^@ http://purl.uniprot.org/uniprot/U3JIM7 ^@ Function|||Similarity ^@ Belongs to the helicase family. Dicer subfamily.|||Double-stranded RNA (dsRNA) endoribonuclease playing a central role in short dsRNA-mediated post-transcriptional gene silencing. Cleaves naturally occurring long dsRNAs and short hairpin pre-microRNAs (miRNA) into fragments of twenty-one to twenty-three nucleotides with 3' overhang of two nucleotides, producing respectively short interfering RNAs (siRNA) and mature microRNAs. SiRNAs and miRNAs serve as guide to direct the RNA-induced silencing complex (RISC) to complementary RNAs to degrade them or prevent their translation. Gene silencing mediated by siRNAs, also called RNA interference, controls the elimination of transcripts from mobile and repetitive DNA elements of the genome but also the degradation of exogenous RNA of viral origin for instance. The miRNA pathway on the other side is a mean to specifically regulate the expression of target genes. http://togogenome.org/gene/59894:LNPEP ^@ http://purl.uniprot.org/uniprot/A0A803VD44|||http://purl.uniprot.org/uniprot/U3JE02 ^@ Similarity ^@ Belongs to the peptidase M1 family. http://togogenome.org/gene/59894:RPS8 ^@ http://purl.uniprot.org/uniprot/U3JRK7 ^@ Similarity ^@ Belongs to the eukaryotic ribosomal protein eS8 family. http://togogenome.org/gene/59894:EMP2 ^@ http://purl.uniprot.org/uniprot/A0A803VVW6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the PMP-22/EMP/MP20 family.|||Cell membrane|||Golgi apparatus membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Membrane raft|||Nucleus|||perinuclear region http://togogenome.org/gene/59894:HSDL1 ^@ http://purl.uniprot.org/uniprot/U3JYZ3 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:ADCYAP1R1 ^@ http://purl.uniprot.org/uniprot/A0A803VKU4|||http://purl.uniprot.org/uniprot/U3JDR5|||http://purl.uniprot.org/uniprot/U3JDS0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:ALB ^@ http://purl.uniprot.org/uniprot/U3K0R0 ^@ Subcellular Location Annotation ^@ Secreted http://togogenome.org/gene/59894:BMP10 ^@ http://purl.uniprot.org/uniprot/A0A803WAF6 ^@ Similarity ^@ Belongs to the TGF-beta family. http://togogenome.org/gene/59894:COL4A5 ^@ http://purl.uniprot.org/uniprot/U3JBN6 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Type IV collagen is the major structural component of glomerular basement membranes (GBM), forming a 'chicken-wire' meshwork together with laminins, proteoglycans and entactin/nidogen.|||basement membrane http://togogenome.org/gene/59894:GAREM1 ^@ http://purl.uniprot.org/uniprot/A0A803V7S9 ^@ Similarity ^@ Belongs to the GAREM family. http://togogenome.org/gene/59894:LAMP5 ^@ http://purl.uniprot.org/uniprot/U3K971 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the LAMP family.|||Endosome membrane http://togogenome.org/gene/59894:VPS18 ^@ http://purl.uniprot.org/uniprot/U3JUE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the VPS18 family.|||Membrane http://togogenome.org/gene/59894:HOXD11 ^@ http://purl.uniprot.org/uniprot/U3KIS8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Abd-B homeobox family.|||Nucleus http://togogenome.org/gene/59894:OSTC ^@ http://purl.uniprot.org/uniprot/U3KCL6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the OSTC family.|||Component of the oligosaccharyltransferase (OST) complex.|||Membrane|||Specific component of the STT3A-containing form of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity. http://togogenome.org/gene/59894:MURC ^@ http://purl.uniprot.org/uniprot/A0A803V013 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola|||sarcomere http://togogenome.org/gene/59894:LOC101810556 ^@ http://purl.uniprot.org/uniprot/U3K475 ^@ Similarity ^@ Belongs to the amidase family. http://togogenome.org/gene/59894:LOC101813310 ^@ http://purl.uniprot.org/uniprot/A0A803VB08|||http://purl.uniprot.org/uniprot/U3JCU6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFS5 subunit family.|||Mammalian complex I is composed of 45 different subunits. This is a component of the iron-sulfur (IP) fragment of the enzyme.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:STMN3 ^@ http://purl.uniprot.org/uniprot/U3JTM4 ^@ Similarity ^@ Belongs to the stathmin family. http://togogenome.org/gene/59894:SLC35A1 ^@ http://purl.uniprot.org/uniprot/A0A803W4I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the nucleotide-sugar transporter family. SLC35A subfamily.|||Membrane http://togogenome.org/gene/59894:TNFAIP6 ^@ http://purl.uniprot.org/uniprot/U3KHH3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:TMEM56 ^@ http://purl.uniprot.org/uniprot/U3JI65 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:CNRIP1 ^@ http://purl.uniprot.org/uniprot/A0A803VYL6 ^@ Function|||Similarity|||Subunit ^@ Belongs to the CNRIP family.|||Interacts with the cannabinoid receptor CNR1 (via C-terminus). Does not interact with cannabinoid receptor CNR2.|||Suppresses cannabinoid receptor CNR1-mediated tonic inhibition of voltage-gated calcium channels. http://togogenome.org/gene/59894:LOC101814109 ^@ http://purl.uniprot.org/uniprot/U3JL78 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MAPK8 ^@ http://purl.uniprot.org/uniprot/U3JYE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Cytoplasm|||Responds to activation by environmental stress and pro-inflammatory cytokines by phosphorylating a number of transcription factors, and thus regulates transcriptional activity. http://togogenome.org/gene/59894:NAAA ^@ http://purl.uniprot.org/uniprot/U3K172 ^@ Similarity ^@ Belongs to the acid ceramidase family. http://togogenome.org/gene/59894:PELI1 ^@ http://purl.uniprot.org/uniprot/U3KGP0 ^@ Similarity ^@ Belongs to the pellino family. http://togogenome.org/gene/59894:REXO2 ^@ http://purl.uniprot.org/uniprot/U3K622 ^@ Similarity ^@ Belongs to the oligoribonuclease family. http://togogenome.org/gene/59894:DGKK ^@ http://purl.uniprot.org/uniprot/A0A803VI52|||http://purl.uniprot.org/uniprot/U3KBN7 ^@ Similarity ^@ Belongs to the eukaryotic diacylglycerol kinase family. http://togogenome.org/gene/59894:MAT2A ^@ http://purl.uniprot.org/uniprot/U3JBF5 ^@ Cofactor|||Function|||Similarity ^@ Belongs to the AdoMet synthase family.|||Binds 1 potassium ion per subunit. The potassium ion interacts primarily with the substrate.|||Binds 2 magnesium ions per subunit. The magnesium ions interact primarily with the substrate.|||Catalyzes the formation of S-adenosylmethionine from methionine and ATP. http://togogenome.org/gene/59894:GLUL ^@ http://purl.uniprot.org/uniprot/U3JZZ9 ^@ Similarity ^@ Belongs to the glutamine synthetase family. http://togogenome.org/gene/59894:LOC101819243 ^@ http://purl.uniprot.org/uniprot/U3KID7 ^@ Cofactor|||Miscellaneous|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Rieske iron-sulfur protein family.|||Binds 1 [2Fe-2S] cluster per subunit.|||Membrane|||Mitochondrion inner membrane|||The Rieske protein is a high potential 2Fe-2S protein. http://togogenome.org/gene/59894:SLC2A9 ^@ http://purl.uniprot.org/uniprot/U3K427 ^@ Similarity ^@ Belongs to the major facilitator superfamily. Sugar transporter (TC 2.A.1.1) family. http://togogenome.org/gene/59894:DPH6 ^@ http://purl.uniprot.org/uniprot/A0A803UZY1|||http://purl.uniprot.org/uniprot/U3JT08 ^@ Similarity ^@ Belongs to the Diphthine--ammonia ligase family. http://togogenome.org/gene/59894:CLN8 ^@ http://purl.uniprot.org/uniprot/A0A803VT31 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:WNT6 ^@ http://purl.uniprot.org/uniprot/A0A803WDE7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the Wnt family.|||Ligand for members of the frizzled family of seven transmembrane receptors.|||extracellular matrix http://togogenome.org/gene/59894:FGF12 ^@ http://purl.uniprot.org/uniprot/A0A803V5E3|||http://purl.uniprot.org/uniprot/U3JXY0 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59894:PRKCE ^@ http://purl.uniprot.org/uniprot/A0A803WBA8|||http://purl.uniprot.org/uniprot/U3KES8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cytoplasm http://togogenome.org/gene/59894:PRPS1 ^@ http://purl.uniprot.org/uniprot/U3K9R5 ^@ Function|||Similarity|||Subunit ^@ Belongs to the ribose-phosphate pyrophosphokinase family.|||Catalyzes the synthesis of phosphoribosylpyrophosphate (PRPP) that is essential for nucleotide synthesis.|||Homodimer. The active form is probably a hexamer composed of 3 homodimers. http://togogenome.org/gene/59894:PDSS1 ^@ http://purl.uniprot.org/uniprot/U3JXK9 ^@ Similarity ^@ Belongs to the FPP/GGPP synthase family. http://togogenome.org/gene/59894:LOC101809845 ^@ http://purl.uniprot.org/uniprot/U3K1U6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.|||Cytoplasm|||May play a role in lipid transport protein in Schwann cells. May bind cholesterol.|||Monomer. http://togogenome.org/gene/59894:SDR42E1 ^@ http://purl.uniprot.org/uniprot/A0A803V6G8 ^@ Similarity ^@ Belongs to the 3-beta-HSD family. http://togogenome.org/gene/59894:LIG3 ^@ http://purl.uniprot.org/uniprot/U3K569 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ATP-dependent DNA ligase family.|||Nucleus http://togogenome.org/gene/59894:PACSIN1 ^@ http://purl.uniprot.org/uniprot/U3JMC6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasmic vesicle membrane|||Membrane|||cytosol|||ruffle membrane|||synaptosome http://togogenome.org/gene/59894:TLX1 ^@ http://purl.uniprot.org/uniprot/U3K1X9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:NUP88 ^@ http://purl.uniprot.org/uniprot/U3K590 ^@ Subcellular Location Annotation ^@ nuclear pore complex http://togogenome.org/gene/59894:UBR1 ^@ http://purl.uniprot.org/uniprot/A0A803V0U1|||http://purl.uniprot.org/uniprot/U3JSN3 ^@ Function|||Similarity ^@ Belongs to the UBR1 family.|||Ubiquitin ligase protein which is a component of the N-end rule pathway. Recognizes and binds to proteins bearing specific N-terminal residues that are destabilizing according to the N-end rule, leading to their ubiquitination and subsequent degradation. http://togogenome.org/gene/59894:RAD21 ^@ http://purl.uniprot.org/uniprot/U3JHZ2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the rad21 family.|||Nucleus http://togogenome.org/gene/59894:KCNAB1 ^@ http://purl.uniprot.org/uniprot/A0A803V0A5|||http://purl.uniprot.org/uniprot/U3JQH7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Cytoplasm|||Membrane http://togogenome.org/gene/59894:TOR1B ^@ http://purl.uniprot.org/uniprot/U3JFE3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ClpA/ClpB family. Torsin subfamily.|||Endoplasmic reticulum lumen http://togogenome.org/gene/59894:CRYBA2 ^@ http://purl.uniprot.org/uniprot/U3JNI8 ^@ Similarity ^@ Belongs to the beta/gamma-crystallin family. http://togogenome.org/gene/59894:LOC101812933 ^@ http://purl.uniprot.org/uniprot/U3JND7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SMP-30/CGR1 family.|||Cytoplasm http://togogenome.org/gene/59894:IDE ^@ http://purl.uniprot.org/uniprot/U3JZT6 ^@ Similarity ^@ Belongs to the peptidase M16 family. http://togogenome.org/gene/59894:SFXN2 ^@ http://purl.uniprot.org/uniprot/U3K247 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:LOC101808610 ^@ http://purl.uniprot.org/uniprot/U3K881 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:RPL11 ^@ http://purl.uniprot.org/uniprot/U3JCM9 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL5 family. http://togogenome.org/gene/59894:MRPL3 ^@ http://purl.uniprot.org/uniprot/U3KDG3 ^@ Similarity ^@ Belongs to the universal ribosomal protein uL3 family. http://togogenome.org/gene/59894:SGCE ^@ http://purl.uniprot.org/uniprot/A0A803W572 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sarcoglycan alpha/epsilon family.|||Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix.|||Golgi apparatus|||dendrite|||sarcolemma http://togogenome.org/gene/59894:SLC25A25 ^@ http://purl.uniprot.org/uniprot/A0A803VH74|||http://purl.uniprot.org/uniprot/A0A803VMJ6|||http://purl.uniprot.org/uniprot/A0A803W3G7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:CUTC ^@ http://purl.uniprot.org/uniprot/A0A803V159|||http://purl.uniprot.org/uniprot/U3K0I0 ^@ Similarity ^@ Belongs to the CutC family. http://togogenome.org/gene/59894:ENSA ^@ http://purl.uniprot.org/uniprot/A0A803VUQ7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the endosulfine family.|||Cytoplasm|||Protein phosphatase inhibitor that specifically inhibits protein phosphatase 2A (PP2A) during mitosis. http://togogenome.org/gene/59894:FLT1 ^@ http://purl.uniprot.org/uniprot/U3K1K4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. Tyr protein kinase family. CSF-1/PDGF receptor subfamily.|||Membrane http://togogenome.org/gene/59894:EIF2S1 ^@ http://purl.uniprot.org/uniprot/A0A803W166 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the eIF-2-alpha family.|||Stress granule http://togogenome.org/gene/59894:SAXO2 ^@ http://purl.uniprot.org/uniprot/A0A803W6L9 ^@ Similarity ^@ Belongs to the FAM154 family. http://togogenome.org/gene/59894:MELTF ^@ http://purl.uniprot.org/uniprot/U3JXB4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the transferrin family.|||Monomer.|||Secreted http://togogenome.org/gene/59894:INHBA ^@ http://purl.uniprot.org/uniprot/U3JRC4 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TGF-beta family.|||Inhibins and activins inhibit and activate, respectively, the secretion of follitropin by the pituitary gland. Inhibins/activins are involved in regulating a number of diverse functions such as hypothalamic and pituitary hormone secretion, gonadal hormone secretion, germ cell development and maturation, erythroid differentiation, insulin secretion, nerve cell survival, embryonic axial development or bone growth, depending on their subunit composition. Inhibins appear to oppose the functions of activins.|||Secreted http://togogenome.org/gene/59894:PRDM16 ^@ http://purl.uniprot.org/uniprot/U3K4P4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:RPTOR ^@ http://purl.uniprot.org/uniprot/A0A803VHD1 ^@ Similarity ^@ Belongs to the WD repeat RAPTOR family. http://togogenome.org/gene/59894:TH ^@ http://purl.uniprot.org/uniprot/U3KAM3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the biopterin-dependent aromatic amino acid hydroxylase family.|||axon|||perinuclear region http://togogenome.org/gene/59894:LOC101810346 ^@ http://purl.uniprot.org/uniprot/U3KKS0 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:LOC107603829 ^@ http://purl.uniprot.org/uniprot/U3KJ41 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:SPIN1 ^@ http://purl.uniprot.org/uniprot/U3KD53 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPIN/STSY family.|||Nucleus http://togogenome.org/gene/59894:TLR4 ^@ http://purl.uniprot.org/uniprot/U3JZ62 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Toll-like receptor family.|||Membrane http://togogenome.org/gene/59894:LOC101808108 ^@ http://purl.uniprot.org/uniprot/U3JHQ0 ^@ Similarity ^@ Belongs to the avidin/streptavidin family. http://togogenome.org/gene/59894:LOC101806598 ^@ http://purl.uniprot.org/uniprot/A0A803VPF1 ^@ Similarity ^@ Belongs to the osteocalcin/matrix Gla protein family. http://togogenome.org/gene/59894:TMCO1 ^@ http://purl.uniprot.org/uniprot/U3JZV0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMCO1 family.|||Calcium-selective channel required to prevent calcium stores from overfilling.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:MCTP1 ^@ http://purl.uniprot.org/uniprot/U3K369 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:LOC101818642 ^@ http://purl.uniprot.org/uniprot/A0A803W4T2 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:ND6 ^@ http://purl.uniprot.org/uniprot/Q7GEM1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the complex I subunit 6 family.|||Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) which catalyzes electron transfer from NADH through the respiratory chain, using ubiquinone as an electron acceptor. Essential for the catalytic activity and assembly of complex I.|||Mitochondrion membrane http://togogenome.org/gene/59894:MTMR8 ^@ http://purl.uniprot.org/uniprot/A0A803VLJ0 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class myotubularin subfamily. http://togogenome.org/gene/59894:LOC101815074 ^@ http://purl.uniprot.org/uniprot/A0A803V8B4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the beta-microseminoprotein family.|||Secreted http://togogenome.org/gene/59894:FUCA2 ^@ http://purl.uniprot.org/uniprot/U3KE10 ^@ Function|||Similarity|||Subunit ^@ Alpha-L-fucosidase is responsible for hydrolyzing the alpha-1,6-linked fucose joined to the reducing-end N-acetylglucosamine of the carbohydrate moieties of glycoproteins.|||Belongs to the glycosyl hydrolase 29 family.|||Homotetramer. http://togogenome.org/gene/59894:LOC101810145 ^@ http://purl.uniprot.org/uniprot/U3JC49 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:SEC31A ^@ http://purl.uniprot.org/uniprot/A0A803W5K3|||http://purl.uniprot.org/uniprot/U3JT16 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC31 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:HN1 ^@ http://purl.uniprot.org/uniprot/U3JES0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the JUPITER family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:GOLPH3L ^@ http://purl.uniprot.org/uniprot/A0A803VHH1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the GOLPH3/VPS74 family.|||Golgi stack membrane|||Membrane|||trans-Golgi network membrane http://togogenome.org/gene/59894:LOC101811856 ^@ http://purl.uniprot.org/uniprot/A0A803V104 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC26A/SulP transporter (TC 2.A.53) family.|||Membrane|||Sulfate transporter. May play a role in endochondral bone formation. http://togogenome.org/gene/59894:L3MBTL1 ^@ http://purl.uniprot.org/uniprot/U3KE81 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101811934 ^@ http://purl.uniprot.org/uniprot/U3JC30 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:RNGTT ^@ http://purl.uniprot.org/uniprot/A0A803VN86|||http://purl.uniprot.org/uniprot/U3JJY2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Bifunctional mRNA-capping enzyme exhibiting RNA 5'-triphosphate monophosphatase activity in the N-terminal part and mRNA guanylyltransferase activity in the C-terminal part. Catalyzes the first two steps of cap formation: by removing the gamma-phosphate from the 5'-triphosphate end of nascent mRNA to yield a diphosphate end, and by transferring the GMP moiety of GTP to the 5'-diphosphate terminus of RNA via a covalent enzyme-GMP reaction intermediate.|||In the C-terminal section; belongs to the eukaryotic GTase family.|||In the N-terminal section; belongs to the non-receptor class of the protein-tyrosine phosphatase family.|||Nucleus http://togogenome.org/gene/59894:CDADC1 ^@ http://purl.uniprot.org/uniprot/U3K116 ^@ Similarity ^@ Belongs to the cytidine and deoxycytidylate deaminase family. http://togogenome.org/gene/59894:THRAP3 ^@ http://purl.uniprot.org/uniprot/A0A803WFT7 ^@ Similarity ^@ Belongs to the BCLAF1/THRAP3 family. http://togogenome.org/gene/59894:PAX5 ^@ http://purl.uniprot.org/uniprot/A0A803VEZ6|||http://purl.uniprot.org/uniprot/U3KEV4 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:HPCAL4 ^@ http://purl.uniprot.org/uniprot/U3JCQ0 ^@ Function ^@ May be involved in the calcium-dependent regulation of rhodopsin phosphorylation. http://togogenome.org/gene/59894:ALDH9A1 ^@ http://purl.uniprot.org/uniprot/U3JZU8 ^@ Similarity ^@ Belongs to the aldehyde dehydrogenase family. http://togogenome.org/gene/59894:LOC101807139 ^@ http://purl.uniprot.org/uniprot/U3KAX8|||http://purl.uniprot.org/uniprot/U3KAY6 ^@ Similarity ^@ Belongs to the CMC4 family.|||Belongs to the TCL1 family. http://togogenome.org/gene/59894:LOC101809163 ^@ http://purl.uniprot.org/uniprot/U3JPK9 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:CPNE4 ^@ http://purl.uniprot.org/uniprot/A0A803VMY3|||http://purl.uniprot.org/uniprot/U3KDC5 ^@ Similarity ^@ Belongs to the copine family. http://togogenome.org/gene/59894:PACSIN2 ^@ http://purl.uniprot.org/uniprot/A0A803V8L9|||http://purl.uniprot.org/uniprot/U3JW22 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PACSIN family.|||Cell membrane|||Cytoplasmic vesicle membrane|||Early endosome|||Endosome membrane|||Membrane|||Recycling endosome membrane|||caveola|||cytoskeleton|||ruffle membrane http://togogenome.org/gene/59894:SSH1 ^@ http://purl.uniprot.org/uniprot/U3K2I7 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. http://togogenome.org/gene/59894:LOC101820552 ^@ http://purl.uniprot.org/uniprot/A0A803V346 ^@ Similarity ^@ Belongs to the glycosyl hydrolase 56 family. http://togogenome.org/gene/59894:LOC101809796 ^@ http://purl.uniprot.org/uniprot/U3JHW6 ^@ Function|||Similarity ^@ Belongs to the SHOC2 family.|||Regulatory subunit of protein phosphatase 1 (PP1c) that acts as a M-Ras/MRAS effector and participates in MAPK pathway activation. Upon M-Ras/MRAS activation, targets PP1c to specifically dephosphorylate the 'Ser-259' inhibitory site of RAF1 kinase and stimulate RAF1 activity at specialized signaling complexes. http://togogenome.org/gene/59894:PSEN2 ^@ http://purl.uniprot.org/uniprot/A0A803VRC2|||http://purl.uniprot.org/uniprot/U3KAI4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the peptidase A22A family.|||Endoplasmic reticulum membrane|||Golgi apparatus membrane|||Homodimer.|||Membrane|||Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral membrane proteins such as Notch receptors.|||The PAL motif is required for normal active site conformation. http://togogenome.org/gene/59894:NDOR1 ^@ http://purl.uniprot.org/uniprot/A0A803WDB3|||http://purl.uniprot.org/uniprot/U3JRQ3 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADPH-dependent diflavin oxidoreductase NDOR1 family.|||In the C-terminal section; belongs to the flavoprotein pyridine nucleotide cytochrome reductase family.|||In the N-terminal section; belongs to the flavodoxin family.|||Interacts with CIAPIN1; as part of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||NADPH-dependent reductase which is a central component of the cytosolic iron-sulfur (Fe-S) protein assembly (CIA) machinery. Transfers electrons from NADPH via its FAD and FMN prosthetic groups to the [2Fe-2S] cluster of CIAPIN1, another key component of the CIA machinery. In turn, this reduced cluster provides electrons for assembly of cytosolic iron-sulfur cluster proteins. It can also reduce the [2Fe-2S] cluster of CISD1 and activate this protein implicated in Fe/S cluster repair.|||perinuclear region http://togogenome.org/gene/59894:LOC101811814 ^@ http://purl.uniprot.org/uniprot/U3KJD8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:NXT2 ^@ http://purl.uniprot.org/uniprot/U3JBN0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Has a role in nuclear-cytoplasmic transport of proteins and mRNAs.|||Nucleus http://togogenome.org/gene/59894:SPTLC3 ^@ http://purl.uniprot.org/uniprot/U3K8R5 ^@ Similarity ^@ Belongs to the class-II pyridoxal-phosphate-dependent aminotransferase family. http://togogenome.org/gene/59894:RBFOX1 ^@ http://purl.uniprot.org/uniprot/A0A803VXM0 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||RNA-binding protein that regulates alternative splicing events. http://togogenome.org/gene/59894:C1S ^@ http://purl.uniprot.org/uniprot/U3JPU3 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:APOD ^@ http://purl.uniprot.org/uniprot/U3JXG3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/59894:YPEL5 ^@ http://purl.uniprot.org/uniprot/A0A803WD76 ^@ Similarity ^@ Belongs to the yippee family. http://togogenome.org/gene/59894:SAT1 ^@ http://purl.uniprot.org/uniprot/A0A803VS73|||http://purl.uniprot.org/uniprot/A0A803W158 ^@ Similarity|||Subunit ^@ Belongs to the acetyltransferase family.|||Homodimer. http://togogenome.org/gene/59894:PAN3 ^@ http://purl.uniprot.org/uniprot/U3K1M4 ^@ Caution|||Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the protein kinase superfamily. PAN3 family.|||Contains a pseudokinase domain. The protein kinase domain is predicted to be catalytically inactive because some of the residues important for catalytic activity are substituted and it lacks the equivalent of the binding site for a peptide substrate. However, it has retained an ATP-binding site and ATP-binding is required for mRNA degradation, stimulating the activity of the PAN2 nuclease in vitro. The nucleotide-binding site is juxtaposed to the RNase active site of PAN2 in the complex and may actually bind nucleosides of a poly(A) RNA rather than ATP, feeding the poly(A)-tail to the active site of the deadenylase and thus increasing the efficiency with which this distributive enzyme degrades oligo(A) RNAs.|||Homodimer. Forms a heterotrimer with a catalytic subunit PAN2 to form the poly(A)-nuclease (PAN) deadenylation complex. Interacts (via PAM-2 motif) with poly(A)-binding protein PABPC1 (via PABC domain), conferring substrate specificity of the enzyme complex. Interacts with the GW182 family proteins TNRC6A, TNRC6B and TNRC6C.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||P-body|||Regulatory subunit of the poly(A)-nuclease (PAN) deadenylation complex, one of two cytoplasmic mRNA deadenylases involved in general and miRNA-mediated mRNA turnover. PAN specifically shortens poly(A) tails of RNA and the activity is stimulated by poly(A)-binding protein (PABP). PAN deadenylation is followed by rapid degradation of the shortened mRNA tails by the CCR4-NOT complex. Deadenylated mRNAs are then degraded by two alternative mechanisms, namely exosome-mediated 3'-5' exonucleolytic degradation, or deadenlyation-dependent mRNA decaping and subsequent 5'-3' exonucleolytic degradation by XRN1. PAN3 acts as a positive regulator for PAN activity, recruiting the catalytic subunit PAN2 to mRNA via its interaction with RNA and PABP, and to miRNA targets via its interaction with GW182 family proteins.|||The N-terminal zinc finger binds to poly(A) RNA.|||The pseudokinase domain, the coiled-coil (CC), and C-terminal knob domain (CK) form a structural unit (PKC) that forms an extensive high-affinity interaction surface for PAN2. http://togogenome.org/gene/59894:NOP58 ^@ http://purl.uniprot.org/uniprot/U3JN70 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NOP5/NOP56 family.|||nucleolus http://togogenome.org/gene/59894:ELMO2 ^@ http://purl.uniprot.org/uniprot/U3JQK7 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Acts in association with DOCK1 and CRK. Was initially proposed to be required in complex with DOCK1 to activate Rac Rho small GTPases. May enhance the guanine nucleotide exchange factor (GEF) activity of DOCK1. http://togogenome.org/gene/59894:CMTR1 ^@ http://purl.uniprot.org/uniprot/U3K9M2 ^@ Function|||Subcellular Location Annotation ^@ Nucleus|||S-adenosyl-L-methionine-dependent methyltransferase that mediates RNA cap1 2'-O-ribose methylation to the 5'-cap structure of RNAs. Methylates the ribose of the first nucleotide of a m(7)GpppG-capped mRNA to produce m(7)GpppNmp (cap1). http://togogenome.org/gene/59894:SEC62 ^@ http://purl.uniprot.org/uniprot/U3K1S9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SEC62 family.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:LOC101816250 ^@ http://purl.uniprot.org/uniprot/U3JG77 ^@ Similarity ^@ Belongs to the HEBP family. http://togogenome.org/gene/59894:UROD ^@ http://purl.uniprot.org/uniprot/U3JR91 ^@ Similarity|||Subunit ^@ Belongs to the uroporphyrinogen decarboxylase family.|||Homodimer. http://togogenome.org/gene/59894:CPM ^@ http://purl.uniprot.org/uniprot/U3K6C3 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:ATP2A3 ^@ http://purl.uniprot.org/uniprot/A0A803W8U9|||http://purl.uniprot.org/uniprot/U3K5W4 ^@ Caution|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IIA subfamily.|||Catalyzes the hydrolysis of ATP coupled with the transport of calcium.|||Endoplasmic reticulum membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Sarcoplasmic reticulum membrane http://togogenome.org/gene/59894:IQCG ^@ http://purl.uniprot.org/uniprot/U3JYL1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DRC9 family.|||flagellum|||flagellum axoneme http://togogenome.org/gene/59894:LOC101811926 ^@ http://purl.uniprot.org/uniprot/U3JZG4 ^@ Similarity ^@ Belongs to the alpha-carbonic anhydrase family. http://togogenome.org/gene/59894:HHATL ^@ http://purl.uniprot.org/uniprot/U3JE59 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:DIS3L2 ^@ http://purl.uniprot.org/uniprot/U3JYX4 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation ^@ 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. Component of an exosome-independent RNA degradation pathway that mediates degradation of both mRNAs and miRNAs that have been polyuridylated by a terminal uridylyltransferase. Essential for correct mitosis, and negatively regulates cell proliferation.|||Belongs to the RNR ribonuclease family. DIS3L2 subfamily.|||Cytoplasm|||P-body|||Specifically recognizes and binds polyuridylated RNAs via 3 RNA-binding regions (named U-zone 1, U-zone 2 and U-zone 3) that form an open funnel on one face of the catalytic domain, allowing RNA to navigate a path to the active site. http://togogenome.org/gene/59894:IKBKAP ^@ http://purl.uniprot.org/uniprot/U3JES9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ELP1/IKA1 family.|||Component of the elongator complex which is required for multiple tRNA modifications, including mcm5U (5-methoxycarbonylmethyl uridine), mcm5s2U (5-methoxycarbonylmethyl-2-thiouridine), and ncm5U (5-carbamoylmethyl uridine). The elongator complex catalyzes formation of carboxymethyluridine in the wobble base at position 34 in tRNAs.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ST3GAL2 ^@ http://purl.uniprot.org/uniprot/U3JY67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:EIF4H ^@ http://purl.uniprot.org/uniprot/A0A803VGS1 ^@ Function|||Subcellular Location Annotation ^@ Stimulates the RNA helicase activity of EIF4A in the translation initiation complex. Binds weakly mRNA.|||perinuclear region http://togogenome.org/gene/59894:LOC101818404 ^@ http://purl.uniprot.org/uniprot/U3KGW5 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:STAC ^@ http://purl.uniprot.org/uniprot/U3JJP5 ^@ Subcellular Location Annotation ^@ sarcolemma http://togogenome.org/gene/59894:FLNB ^@ http://purl.uniprot.org/uniprot/U3K0X6 ^@ Similarity ^@ Belongs to the filamin family. http://togogenome.org/gene/59894:PDE6D ^@ http://purl.uniprot.org/uniprot/U3JYV3 ^@ Similarity ^@ Belongs to the PDE6D/unc-119 family. http://togogenome.org/gene/59894:EYA2 ^@ http://purl.uniprot.org/uniprot/U3JRC8 ^@ Cofactor|||Similarity|||Subcellular Location Annotation ^@ Belongs to the HAD-like hydrolase superfamily. EYA family.|||Binds 1 Mg(2+) ion per subunit.|||Nucleus http://togogenome.org/gene/59894:FGF7 ^@ http://purl.uniprot.org/uniprot/A0A803VCF6 ^@ Similarity ^@ Belongs to the heparin-binding growth factors family. http://togogenome.org/gene/59894:RALA ^@ http://purl.uniprot.org/uniprot/A0A803VJ18 ^@ Similarity ^@ Belongs to the small GTPase superfamily. Ras family. http://togogenome.org/gene/59894:TP63 ^@ http://purl.uniprot.org/uniprot/A0A803VMQ3|||http://purl.uniprot.org/uniprot/U3JY64 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Acts as a sequence specific DNA binding transcriptional activator or repressor. The isoforms contain a varying set of transactivation and auto-regulating transactivation inhibiting domains thus showing an isoform specific activity. May be required in conjunction with TP73/p73 for initiation of p53/TP53 dependent apoptosis in response to genotoxic insults and the presence of activated oncogenes.|||Belongs to the p53 family.|||Binds 1 zinc ion per subunit.|||Binds DNA as a homotetramer. Isoform composition of the tetramer may determine transactivation activity.|||Nucleus http://togogenome.org/gene/59894:TTC27 ^@ http://purl.uniprot.org/uniprot/U3KBX5 ^@ Similarity ^@ Belongs to the TTC27 family. http://togogenome.org/gene/59894:TRPV4 ^@ http://purl.uniprot.org/uniprot/U3K251 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:SERINC1 ^@ http://purl.uniprot.org/uniprot/U3K9Y2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TDE1 family.|||Membrane http://togogenome.org/gene/59894:KCNA10 ^@ http://purl.uniprot.org/uniprot/A0A803W9Q2 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:OSBPL8 ^@ http://purl.uniprot.org/uniprot/A0A803VEW4|||http://purl.uniprot.org/uniprot/A0A803W996|||http://purl.uniprot.org/uniprot/U3K748 ^@ Similarity ^@ Belongs to the OSBP family. http://togogenome.org/gene/59894:HGFAC ^@ http://purl.uniprot.org/uniprot/U3K538 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:METTL16 ^@ http://purl.uniprot.org/uniprot/U3JRR9 ^@ Function|||Similarity ^@ Belongs to the methyltransferase superfamily. METTL16/RlmF family.|||RNA N6-methyltransferase that methylates adenosine residues at the N(6) position of a subset of RNAs and is involved in S-adenosyl-L-methionine homeostasis by regulating expression of MAT2A transcripts. Able to N6-methylate a subset of mRNAs and U6 small nuclear RNAs (U6 snRNAs). In contrast to the METTL3-METTL14 heterodimer, only able to methylate a limited number of RNAs: requires both a 5'UACAGAGAA-3' nonamer sequence and a specific RNA structure. http://togogenome.org/gene/59894:DZIP1 ^@ http://purl.uniprot.org/uniprot/U3JPG2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the DZIP C2H2-type zinc-finger protein family.|||centriole|||cilium basal body http://togogenome.org/gene/59894:LOC101822002 ^@ http://purl.uniprot.org/uniprot/U3KHZ0 ^@ Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family. http://togogenome.org/gene/59894:DYM ^@ http://purl.uniprot.org/uniprot/A0A803VAX3|||http://purl.uniprot.org/uniprot/A0A803W3E8|||http://purl.uniprot.org/uniprot/U3K2T9|||http://purl.uniprot.org/uniprot/U3K2U1 ^@ Similarity ^@ Belongs to the dymeclin family. http://togogenome.org/gene/59894:WSCD2 ^@ http://purl.uniprot.org/uniprot/U3K2P5 ^@ Similarity ^@ Belongs to the WSCD family. http://togogenome.org/gene/59894:PTK2 ^@ http://purl.uniprot.org/uniprot/U3JJM0 ^@ Subcellular Location Annotation ^@ Cell membrane|||focal adhesion http://togogenome.org/gene/59894:ZEB2 ^@ http://purl.uniprot.org/uniprot/A0A803VDL1 ^@ Similarity ^@ Belongs to the delta-EF1/ZFH-1 C2H2-type zinc-finger family. http://togogenome.org/gene/59894:LOC101812329 ^@ http://purl.uniprot.org/uniprot/U3JC21 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LHFPL4 ^@ http://purl.uniprot.org/uniprot/U3KE51 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:STK4 ^@ http://purl.uniprot.org/uniprot/U3JS76 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||Nucleus http://togogenome.org/gene/59894:ABCG4 ^@ http://purl.uniprot.org/uniprot/U3JUB8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ABC transporter superfamily. ABCG family. Eye pigment precursor importer (TC 3.A.1.204) subfamily.|||Membrane http://togogenome.org/gene/59894:PKM ^@ http://purl.uniprot.org/uniprot/A0A803VBL7|||http://purl.uniprot.org/uniprot/U3K4X2 ^@ Similarity ^@ Belongs to the pyruvate kinase family. http://togogenome.org/gene/59894:TRAK2 ^@ http://purl.uniprot.org/uniprot/A0A803VNJ0|||http://purl.uniprot.org/uniprot/U3JND8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the milton family.|||Early endosome|||Mitochondrion http://togogenome.org/gene/59894:PGAP2 ^@ http://purl.uniprot.org/uniprot/U3K6J6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP2 family.|||Involved in the lipid remodeling steps of GPI-anchor maturation. Required for stable expression of GPI-anchored proteins at the cell surface.|||Membrane http://togogenome.org/gene/59894:SLC8B1 ^@ http://purl.uniprot.org/uniprot/U3JZ77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:PIK3R3 ^@ http://purl.uniprot.org/uniprot/U3K4G9 ^@ Similarity ^@ Belongs to the PI3K p85 subunit family. http://togogenome.org/gene/59894:NAGA ^@ http://purl.uniprot.org/uniprot/U3KB71 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the glycosyl hydrolase 27 family.|||Homodimer.|||Lysosome http://togogenome.org/gene/59894:LOC101820640 ^@ http://purl.uniprot.org/uniprot/U3JJ51 ^@ Similarity ^@ Belongs to the protein-tyrosine phosphatase family. Receptor class 3 subfamily. http://togogenome.org/gene/59894:LOC101816899 ^@ http://purl.uniprot.org/uniprot/U3KL15 ^@ Similarity ^@ Belongs to the sulfotransferase 1 family. http://togogenome.org/gene/59894:PRDM4 ^@ http://purl.uniprot.org/uniprot/U3KFW7 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:LOC101818231 ^@ http://purl.uniprot.org/uniprot/U3JQR7 ^@ Function|||Similarity ^@ Belongs to the alpha-carbonic anhydrase family.|||Reversible hydration of carbon dioxide. http://togogenome.org/gene/59894:RPL5 ^@ http://purl.uniprot.org/uniprot/U3JG93|||http://purl.uniprot.org/uniprot/U3JG95 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the universal ribosomal protein uL18 family.|||Cytoplasm http://togogenome.org/gene/59894:DEF8 ^@ http://purl.uniprot.org/uniprot/U3JK36 ^@ Similarity ^@ Belongs to the DEF8 family. http://togogenome.org/gene/59894:ACTB ^@ http://purl.uniprot.org/uniprot/U3KHC4 ^@ Similarity ^@ Belongs to the actin family. http://togogenome.org/gene/59894:SFXN3 ^@ http://purl.uniprot.org/uniprot/U3K1Y6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the sideroflexin family.|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane|||Mitochondrion membrane http://togogenome.org/gene/59894:UBA3 ^@ http://purl.uniprot.org/uniprot/U3KFZ2 ^@ Function|||Similarity ^@ Belongs to the ubiquitin-activating E1 family. UBA3 subfamily.|||Catalytic subunit of the dimeric E1 enzyme, which activates NEDD8. http://togogenome.org/gene/59894:DDT ^@ http://purl.uniprot.org/uniprot/U3JXP7 ^@ Similarity ^@ Belongs to the MIF family. http://togogenome.org/gene/59894:CDX1 ^@ http://purl.uniprot.org/uniprot/U3JZT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Caudal homeobox family.|||Nucleus http://togogenome.org/gene/59894:LIPH ^@ http://purl.uniprot.org/uniprot/U3KG45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/59894:KCNAB2 ^@ http://purl.uniprot.org/uniprot/U3K533|||http://purl.uniprot.org/uniprot/U3K536 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the shaker potassium channel beta subunit family.|||Cell membrane|||Membrane|||axon|||cytoskeleton|||synaptosome http://togogenome.org/gene/59894:LIPI ^@ http://purl.uniprot.org/uniprot/U3KCB5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AB hydrolase superfamily. Lipase family.|||Secreted http://togogenome.org/gene/59894:SEPHS1 ^@ http://purl.uniprot.org/uniprot/U3JGT1 ^@ Function ^@ Synthesizes selenophosphate from selenide and ATP. http://togogenome.org/gene/59894:CCT5 ^@ http://purl.uniprot.org/uniprot/U3JZG1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TCP-1 chaperonin family.|||Cytoplasm http://togogenome.org/gene/59894:LRRCC1 ^@ http://purl.uniprot.org/uniprot/U3JQM6 ^@ Similarity ^@ Belongs to the SDS22 family. http://togogenome.org/gene/59894:TNFSF15 ^@ http://purl.uniprot.org/uniprot/U3JS18 ^@ Similarity ^@ Belongs to the tumor necrosis factor family. http://togogenome.org/gene/59894:DOCK9 ^@ http://purl.uniprot.org/uniprot/A0A803VQ98 ^@ Similarity ^@ Belongs to the DOCK family. http://togogenome.org/gene/59894:TUB ^@ http://purl.uniprot.org/uniprot/A0A803V2S9|||http://purl.uniprot.org/uniprot/A0A803VK12|||http://purl.uniprot.org/uniprot/U3JDT3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TUB family.|||Secreted http://togogenome.org/gene/59894:PKN2 ^@ http://purl.uniprot.org/uniprot/U3JFZ3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. AGC Ser/Thr protein kinase family. PKC subfamily.|||Cleavage furrow|||Midbody|||Nucleus http://togogenome.org/gene/59894:GRPR ^@ http://purl.uniprot.org/uniprot/U3JP43 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SYNM ^@ http://purl.uniprot.org/uniprot/U3K6W0 ^@ Similarity ^@ Belongs to the intermediate filament family. http://togogenome.org/gene/59894:LOC101807456 ^@ http://purl.uniprot.org/uniprot/A0A803V2S4|||http://purl.uniprot.org/uniprot/A0A803W6C1|||http://purl.uniprot.org/uniprot/U3JLM9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITIH family.|||Secreted http://togogenome.org/gene/59894:CLDN3 ^@ http://purl.uniprot.org/uniprot/U3KIP2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the claudin family.|||Can form homo- and heteropolymers with other CLDN. Homopolymers interact with CLDN1 and CLDN2 homopolymers. Directly interacts with TJP1/ZO-1, TJP2/ZO-2 and TJP3/ZO-3.|||Cell membrane|||Membrane|||Plays a major role in tight junction-specific obliteration of the intercellular space, through calcium-independent cell-adhesion activity.|||tight junction http://togogenome.org/gene/59894:CSNK2A1 ^@ http://purl.uniprot.org/uniprot/U3JT45 ^@ Similarity ^@ Belongs to the protein kinase superfamily. http://togogenome.org/gene/59894:PXN ^@ http://purl.uniprot.org/uniprot/A0A803V1D5|||http://purl.uniprot.org/uniprot/U3JYT9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the paxillin family.|||cell cortex|||cytoskeleton|||focal adhesion http://togogenome.org/gene/59894:SF3B3 ^@ http://purl.uniprot.org/uniprot/U3JY42 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ALDH18A1 ^@ http://purl.uniprot.org/uniprot/U3JF52 ^@ Similarity ^@ In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family.|||In the N-terminal section; belongs to the glutamate 5-kinase family. http://togogenome.org/gene/59894:LHX9 ^@ http://purl.uniprot.org/uniprot/U3JJD3 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ENTPD1 ^@ http://purl.uniprot.org/uniprot/U3K018 ^@ Similarity ^@ Belongs to the GDA1/CD39 NTPase family. http://togogenome.org/gene/59894:LOC101822280 ^@ http://purl.uniprot.org/uniprot/U3K542 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cation transport ATPase (P-type) (TC 3.A.3) family. Type IV subfamily.|||Membrane http://togogenome.org/gene/59894:CERS6 ^@ http://purl.uniprot.org/uniprot/U3JDC3 ^@ Subcellular Location Annotation ^@ Endoplasmic reticulum membrane|||Membrane|||Nucleus http://togogenome.org/gene/59894:ZMPSTE24 ^@ http://purl.uniprot.org/uniprot/U3JEA8 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase M48A family.|||Binds 1 zinc ion per subunit.|||Endoplasmic reticulum membrane|||Proteolytically removes the C-terminal three residues of farnesylated proteins. http://togogenome.org/gene/59894:ITPR1 ^@ http://purl.uniprot.org/uniprot/U3KGK2 ^@ Domain|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the InsP3 receptor family.|||Endoplasmic reticulum membrane|||Homotetramer.|||Membrane|||Receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium.|||The receptor contains a calcium channel in its C-terminal extremity. Its large N-terminal cytoplasmic region has the ligand-binding site in the N-terminus and modulatory sites in the middle portion immediately upstream of the channel region. http://togogenome.org/gene/59894:MIOS ^@ http://purl.uniprot.org/uniprot/U3K6I2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat mio family.|||Lysosome membrane http://togogenome.org/gene/59894:CREB3L3 ^@ http://purl.uniprot.org/uniprot/U3JDT4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the bZIP family. ATF subfamily.|||Endoplasmic reticulum membrane|||Membrane http://togogenome.org/gene/59894:CLPTM1L ^@ http://purl.uniprot.org/uniprot/U3JHI8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CLPTM1 family.|||Membrane http://togogenome.org/gene/59894:FDFT1 ^@ http://purl.uniprot.org/uniprot/U3JIK8 ^@ Function|||Similarity ^@ Belongs to the phytoene/squalene synthase family.|||Catalyzes the condensation of 2 farnesyl pyrophosphate (FPP) moieties to form squalene. http://togogenome.org/gene/59894:AMN ^@ http://purl.uniprot.org/uniprot/U3JJE6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101806046 ^@ http://purl.uniprot.org/uniprot/U3KAH5 ^@ Similarity ^@ Belongs to the CD225/Dispanin family. http://togogenome.org/gene/59894:UBE2G1 ^@ http://purl.uniprot.org/uniprot/A0A803VGU7|||http://purl.uniprot.org/uniprot/U3JXI5 ^@ Similarity ^@ Belongs to the ubiquitin-conjugating enzyme family. http://togogenome.org/gene/59894:LOC101814608 ^@ http://purl.uniprot.org/uniprot/U3JN63 ^@ Similarity ^@ Belongs to the CNKSR family. http://togogenome.org/gene/59894:ERCC5 ^@ http://purl.uniprot.org/uniprot/U3JNQ0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the XPG/RAD2 endonuclease family. XPG subfamily.|||Nucleus http://togogenome.org/gene/59894:LOC101822066 ^@ http://purl.uniprot.org/uniprot/U3JVX3 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the cytochrome c oxidase IV family.|||Component of the cytochrome c oxidase (complex IV, CIV), a multisubunit enzyme composed of 14 subunits.|||Component of the cytochrome c oxidase, the last enzyme in the mitochondrial electron transport chain which drives oxidative phosphorylation.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:AIG1 ^@ http://purl.uniprot.org/uniprot/U3KE35 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the AIG1 family.|||Membrane http://togogenome.org/gene/59894:PM20D2 ^@ http://purl.uniprot.org/uniprot/U3JJZ8 ^@ Similarity ^@ Belongs to the peptidase M20A family. http://togogenome.org/gene/59894:BICD1 ^@ http://purl.uniprot.org/uniprot/A0A803V6V7|||http://purl.uniprot.org/uniprot/A0A803VKC0|||http://purl.uniprot.org/uniprot/A0A803VQI2|||http://purl.uniprot.org/uniprot/A0A803WDK1|||http://purl.uniprot.org/uniprot/U3K305 ^@ Similarity ^@ Belongs to the BicD family. http://togogenome.org/gene/59894:AMBP ^@ http://purl.uniprot.org/uniprot/A0A803WCP2 ^@ Similarity|||Subcellular Location Annotation ^@ In the N-terminal section; belongs to the calycin superfamily. Lipocalin family.|||Secreted http://togogenome.org/gene/59894:TFB1M ^@ http://purl.uniprot.org/uniprot/A0A803V9I3 ^@ Similarity ^@ Belongs to the class I-like SAM-binding methyltransferase superfamily. rRNA adenine N(6)-methyltransferase family. http://togogenome.org/gene/59894:EVPL ^@ http://purl.uniprot.org/uniprot/U3JE24 ^@ Subcellular Location Annotation ^@ cytoskeleton http://togogenome.org/gene/59894:APH1A ^@ http://purl.uniprot.org/uniprot/U3JHL2 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the APH-1 family.|||Component of the gamma-secretase complex.|||Membrane|||Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. http://togogenome.org/gene/59894:GNAL ^@ http://purl.uniprot.org/uniprot/A0A803W037|||http://purl.uniprot.org/uniprot/U3JV91 ^@ Similarity ^@ Belongs to the G-alpha family. G(s) subfamily. http://togogenome.org/gene/59894:ZP3 ^@ http://purl.uniprot.org/uniprot/U3KCP3 ^@ Domain|||Function|||PTM|||Similarity|||Subcellular Location Annotation ^@ Belongs to the ZP domain family. ZPC subfamily.|||Cell membrane|||Component of the zona pellucida, an extracellular matrix surrounding oocytes which mediates sperm binding, induction of the acrosome reaction and prevents post-fertilization polyspermy. The zona pellucida is composed of 3 to 4 glycoproteins, ZP1, ZP2, ZP3, and ZP4. ZP3 is essential for sperm binding and zona matrix formation.|||Proteolytically cleaved before the transmembrane segment to yield the secreted ectodomain incorporated in the zona pellucida.|||The ZP domain is involved in the polymerization of the ZP proteins to form the zona pellucida.|||Zona pellucida http://togogenome.org/gene/59894:MFN1 ^@ http://purl.uniprot.org/uniprot/U3K134 ^@ Subcellular Location Annotation ^@ Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:LPCAT2 ^@ http://purl.uniprot.org/uniprot/U3JZN1 ^@ Similarity ^@ Belongs to the 1-acyl-sn-glycerol-3-phosphate acyltransferase family. http://togogenome.org/gene/59894:CDH13 ^@ http://purl.uniprot.org/uniprot/A0A803VZP9|||http://purl.uniprot.org/uniprot/U3JW62 ^@ Function|||Subcellular Location Annotation|||Subunit ^@ By contrast to classical cadherins, homodimerization in trans is not mediated by cadherin EC1 domain strand-swapping, but instead through a homophilic adhesive interface which joins two elongated EC1-EC2 domains through a region near their Ca2+-binding sites to form a tetrahedral, X-like shape.|||Cadherins are calcium-dependent cell adhesion proteins. They preferentially interact with themselves in a homophilic manner in connecting cells; cadherins may thus contribute to the sorting of heterogeneous cell types. May act as a negative regulator of neural cell growth.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101811630 ^@ http://purl.uniprot.org/uniprot/U3KKZ4 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the histone H2B family.|||Nucleus|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:SLC52A3 ^@ http://purl.uniprot.org/uniprot/U3JT59 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the riboflavin transporter family.|||Cell membrane|||Membrane|||Plasma membrane transporter mediating the uptake by cells of the water soluble vitamin B2/riboflavin that plays a key role in biochemical oxidation-reduction reactions of the carbohydrate, lipid, and amino acid metabolism. http://togogenome.org/gene/59894:PTH1R ^@ http://purl.uniprot.org/uniprot/U3JRU3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:SLC10A2 ^@ http://purl.uniprot.org/uniprot/U3JNP3 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the bile acid:sodium symporter (BASS) (TC 2.A.28) family.|||Membrane|||Monomer and homodimer. http://togogenome.org/gene/59894:BTF3 ^@ http://purl.uniprot.org/uniprot/U3K6L2 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/59894:PICK1 ^@ http://purl.uniprot.org/uniprot/U3KDZ4 ^@ Function|||Subcellular Location Annotation ^@ Membrane|||Probable adapter protein that bind to and organize the subcellular localization of a variety of membrane proteins containing some PDZ recognition sequence. Involved in the clustering of various receptors, possibly by acting at the receptor internalization level. Plays a role in synaptic plasticity by regulating the trafficking and internalization of AMPA receptors. May be regulated upon PRKCA activation. May regulate ASIC1/ASIC3 channel. Regulates actin polymerization by inhibiting the actin-nucleating activity of the Arp2/3 complex; the function is competitive with nucleation promoting factors and is linked to neuronal morphology regulation and AMPA receptor (AMPAR) endocytosis. Via interaction with the Arp2/3 complex involved in regulation of synaptic plasicity of excitatory synapses and required for spine shrinkage during long-term depression (LTD). Involved in regulation of astrocyte morphology, antagonistic to Arp2/3 complex activator WASL/N-WASP function.|||cytoskeleton|||perinuclear region|||synaptosome http://togogenome.org/gene/59894:DNAH1 ^@ http://purl.uniprot.org/uniprot/U3K2L1 ^@ Similarity ^@ Belongs to the dynein heavy chain family. http://togogenome.org/gene/59894:IL7R ^@ http://purl.uniprot.org/uniprot/U3JHB6 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the type I cytokine receptor family. Type 4 subfamily.|||Membrane|||Receptor for interleukin-7. Also acts as a receptor for thymic stromal lymphopoietin (TSLP).|||The IL7 receptor is a heterodimer of IL7R and IL2RG. The TSLP receptor is a heterodimer of CRLF2 and IL7R. http://togogenome.org/gene/59894:FAM110B ^@ http://purl.uniprot.org/uniprot/U3KK97 ^@ Similarity ^@ Belongs to the FAM110 family. http://togogenome.org/gene/59894:OGG1 ^@ http://purl.uniprot.org/uniprot/A0A803W6W3 ^@ Similarity ^@ Belongs to the type-1 OGG1 family. http://togogenome.org/gene/59894:RPS14 ^@ http://purl.uniprot.org/uniprot/A0A803VYV8 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS11 family. http://togogenome.org/gene/59894:CPLX2 ^@ http://purl.uniprot.org/uniprot/A0A803VDT7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the complexin/synaphin family.|||Synapse http://togogenome.org/gene/59894:ERI1 ^@ http://purl.uniprot.org/uniprot/A0A803WA18 ^@ Subcellular Location Annotation ^@ Cytoplasm http://togogenome.org/gene/59894:NCAPD2 ^@ http://purl.uniprot.org/uniprot/A0A803V287|||http://purl.uniprot.org/uniprot/U3JQH0 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the CND1 (condensin subunit 1) family.|||Chromosome|||Nucleus|||Regulatory subunit of the condensin complex, a complex required for conversion of interphase chromatin into mitotic-like condense chromosomes. The condensin complex probably introduces positive supercoils into relaxed DNA in the presence of type I topoisomerases and converts nicked DNA into positive knotted forms in the presence of type II topoisomerases. http://togogenome.org/gene/59894:CDH9 ^@ http://purl.uniprot.org/uniprot/U3KE89 ^@ Function|||Subcellular Location Annotation ^@ Cadherins are calcium-dependent cell adhesion proteins.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:LOC101816121 ^@ http://purl.uniprot.org/uniprot/U3JIW7 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:MSANTD3 ^@ http://purl.uniprot.org/uniprot/U3JQL6 ^@ Similarity ^@ Belongs to the MSANTD3 family. http://togogenome.org/gene/59894:USP22 ^@ http://purl.uniprot.org/uniprot/U3KH88 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:PLA2G4A ^@ http://purl.uniprot.org/uniprot/A0A803VZZ0 ^@ Domain ^@ The N-terminal C2 domain associates with lipid membranes upon calcium binding. http://togogenome.org/gene/59894:PLPPR5 ^@ http://purl.uniprot.org/uniprot/A0A803VJK0|||http://purl.uniprot.org/uniprot/A0A803W3D4|||http://purl.uniprot.org/uniprot/A0A803WCA0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the PA-phosphatase related phosphoesterase family.|||Membrane http://togogenome.org/gene/59894:KCNB2 ^@ http://purl.uniprot.org/uniprot/U3K1I0 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.2/KCNB2 sub-subfamily.|||Cell membrane|||Membrane|||Perikaryon http://togogenome.org/gene/59894:LOC101817434 ^@ http://purl.uniprot.org/uniprot/U3JLP3 ^@ Similarity|||Subunit ^@ Belongs to the protein kinase superfamily. CMGC Ser/Thr protein kinase family. MAP kinase subfamily.|||Interacts with MAPK8IP2. http://togogenome.org/gene/59894:SLC7A1 ^@ http://purl.uniprot.org/uniprot/A0A803V067|||http://purl.uniprot.org/uniprot/U3K1J2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the amino acid-polyamine-organocation (APC) superfamily. Cationic amino acid transporter (CAT) (TC 2.A.3.3) family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:RHOT1 ^@ http://purl.uniprot.org/uniprot/A0A803V2D8|||http://purl.uniprot.org/uniprot/A0A803W1W4|||http://purl.uniprot.org/uniprot/U3JHY1 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial Rho GTPase family.|||Membrane|||Mitochondrial GTPase involved in mitochondrial trafficking.|||Mitochondrion outer membrane http://togogenome.org/gene/59894:INPP5B ^@ http://purl.uniprot.org/uniprot/U3JE26 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the inositol 1,4,5-trisphosphate 5-phosphatase type II family.|||Early endosome membrane|||Endosome membrane|||Membrane|||phagosome membrane http://togogenome.org/gene/59894:NRDE2 ^@ http://purl.uniprot.org/uniprot/U3KCP8 ^@ Similarity ^@ Belongs to the NRDE2 family. http://togogenome.org/gene/59894:TFAP2B ^@ http://purl.uniprot.org/uniprot/A0A803WCW7 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/59894:LOC101815107 ^@ http://purl.uniprot.org/uniprot/U3JCD0 ^@ Similarity ^@ Belongs to the short-chain dehydrogenases/reductases (SDR) family. http://togogenome.org/gene/59894:ACAT2 ^@ http://purl.uniprot.org/uniprot/U3KC85 ^@ Similarity ^@ Belongs to the thiolase-like superfamily. Thiolase family. http://togogenome.org/gene/59894:PROZ ^@ http://purl.uniprot.org/uniprot/A0A803W3B6|||http://purl.uniprot.org/uniprot/U3JKN6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ATP1B3 ^@ http://purl.uniprot.org/uniprot/U3JWY6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the X(+)/potassium ATPases subunit beta family.|||Membrane|||This is the non-catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of Na(+) and K(+) ions across the plasma membrane. http://togogenome.org/gene/59894:SEC13 ^@ http://purl.uniprot.org/uniprot/A0A803VVT8 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat SEC13 family.|||Lysosome membrane|||nuclear pore complex http://togogenome.org/gene/59894:CACYBP ^@ http://purl.uniprot.org/uniprot/A0A803W0L0 ^@ Function|||Subcellular Location Annotation ^@ Cytoplasm|||May be involved in calcium-dependent ubiquitination and subsequent proteasomal degradation of target proteins. Probably serves as a molecular bridge in ubiquitin E3 complexes. Participates in the ubiquitin-mediated degradation of beta-catenin (CTNNB1).|||Nucleus http://togogenome.org/gene/59894:ACVRL1 ^@ http://purl.uniprot.org/uniprot/U3JBE5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein kinase superfamily. TKL Ser/Thr protein kinase family. TGFB receptor subfamily.|||Membrane http://togogenome.org/gene/59894:BTF3L4 ^@ http://purl.uniprot.org/uniprot/A0A803V3J7 ^@ Similarity ^@ Belongs to the NAC-beta family. http://togogenome.org/gene/59894:LOC101807405 ^@ http://purl.uniprot.org/uniprot/U3JCL3 ^@ Similarity ^@ Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family. http://togogenome.org/gene/59894:SYNGR3 ^@ http://purl.uniprot.org/uniprot/U3JLE9 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the synaptogyrin family.|||Membrane http://togogenome.org/gene/59894:RHPN2 ^@ http://purl.uniprot.org/uniprot/U3JBW9 ^@ Similarity ^@ Belongs to the RHPN family. http://togogenome.org/gene/59894:TMEM178B ^@ http://purl.uniprot.org/uniprot/U3JMF0 ^@ Similarity ^@ Belongs to the TMEM178 family. http://togogenome.org/gene/59894:GCSH ^@ http://purl.uniprot.org/uniprot/U3JWH2 ^@ Cofactor|||Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the GcvH family.|||Binds 1 lipoyl cofactor covalently.|||Mitochondrion|||The H protein shuttles the methylamine group of glycine from the P protein to the T protein.|||The glycine cleavage system catalyzes the degradation of glycine. The H protein (GCSH) shuttles the methylamine group of glycine from the P protein (GLDC) to the T protein (GCST).|||The glycine cleavage system is composed of four proteins: P, T, L and H. http://togogenome.org/gene/59894:FN3K ^@ http://purl.uniprot.org/uniprot/A0A803WDW8 ^@ Similarity ^@ Belongs to the fructosamine kinase family. http://togogenome.org/gene/59894:LOC101817939 ^@ http://purl.uniprot.org/uniprot/U3JWR6 ^@ Subcellular Location Annotation ^@ Membrane|||Membrane raft|||Secreted http://togogenome.org/gene/59894:TOLLIP ^@ http://purl.uniprot.org/uniprot/A0A803V6G1|||http://purl.uniprot.org/uniprot/A0A803VZZ5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tollip family.|||Cytoplasm http://togogenome.org/gene/59894:NETO1 ^@ http://purl.uniprot.org/uniprot/U3JPW6 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ST8SIA2 ^@ http://purl.uniprot.org/uniprot/U3K720 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:GFOD2 ^@ http://purl.uniprot.org/uniprot/U3JWV2 ^@ Similarity ^@ Belongs to the Gfo/Idh/MocA family. http://togogenome.org/gene/59894:SLC16A10 ^@ http://purl.uniprot.org/uniprot/U3K8F5 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:C2H6orf52 ^@ http://purl.uniprot.org/uniprot/A0A803VCJ1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the RRM TRSPAP family.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:PDGFB ^@ http://purl.uniprot.org/uniprot/U3KD28 ^@ Similarity ^@ Belongs to the PDGF/VEGF growth factor family. http://togogenome.org/gene/59894:CCND2 ^@ http://purl.uniprot.org/uniprot/A0A803VIP2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the cyclin family. Cyclin D subfamily.|||Cytoplasm|||Nucleus http://togogenome.org/gene/59894:ORC5 ^@ http://purl.uniprot.org/uniprot/U3K6Y8 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:GABRA5 ^@ http://purl.uniprot.org/uniprot/U3JN42 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ligand-gated ion channel (TC 1.A.9) family.|||Cell membrane|||Membrane|||Postsynaptic cell membrane|||Synaptic cell membrane http://togogenome.org/gene/59894:BFSP1 ^@ http://purl.uniprot.org/uniprot/U3KGV6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Membrane|||cell cortex|||cytoskeleton http://togogenome.org/gene/59894:TMCC1 ^@ http://purl.uniprot.org/uniprot/U3KGX2 ^@ Similarity ^@ Belongs to the TEX28 family. http://togogenome.org/gene/59894:MRPS9 ^@ http://purl.uniprot.org/uniprot/U3JM10 ^@ Similarity ^@ Belongs to the universal ribosomal protein uS9 family. http://togogenome.org/gene/59894:LOC101806331 ^@ http://purl.uniprot.org/uniprot/U3JMY8 ^@ Function|||Similarity ^@ Belongs to the PET191 family.|||Involved in an early step of the mitochondrial complex IV assembly process. http://togogenome.org/gene/59894:CKAP2 ^@ http://purl.uniprot.org/uniprot/U3K1L7 ^@ Similarity ^@ Belongs to the CKAP2 family. http://togogenome.org/gene/59894:HNRNPDL ^@ http://purl.uniprot.org/uniprot/U3JT46 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SH3GLB1 ^@ http://purl.uniprot.org/uniprot/U3JUV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the endophilin family.|||Cytoplasm|||Golgi apparatus membrane|||Membrane|||Mitochondrion outer membrane http://togogenome.org/gene/59894:LOC101820328 ^@ http://purl.uniprot.org/uniprot/A0A803V056 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the sodium:neurotransmitter symporter (SNF) (TC 2.A.22) family.|||Membrane http://togogenome.org/gene/59894:ACSL1 ^@ http://purl.uniprot.org/uniprot/U3KBD1 ^@ Function|||Similarity ^@ Belongs to the ATP-dependent AMP-binding enzyme family.|||Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. http://togogenome.org/gene/59894:XYLB ^@ http://purl.uniprot.org/uniprot/A0A803VMU3|||http://purl.uniprot.org/uniprot/U3JWE7 ^@ Function|||Similarity ^@ Belongs to the FGGY kinase family.|||Phosphorylates D-xylulose to produce D-xylulose 5-phosphate, a molecule that may play an important role in the regulation of glucose metabolism and lipogenesis. http://togogenome.org/gene/59894:PTGR2 ^@ http://purl.uniprot.org/uniprot/U3JSL5 ^@ Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the NADP-dependent oxidoreductase L4BD family.|||Cytoplasm|||Monomer. http://togogenome.org/gene/59894:SENP2 ^@ http://purl.uniprot.org/uniprot/U3KFV4 ^@ Similarity ^@ Belongs to the peptidase C48 family. http://togogenome.org/gene/59894:PNPT1 ^@ http://purl.uniprot.org/uniprot/U3K9J3 ^@ Similarity ^@ Belongs to the polyribonucleotide nucleotidyltransferase family. http://togogenome.org/gene/59894:PARVA ^@ http://purl.uniprot.org/uniprot/U3K7T1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the parvin family.|||cytoskeleton http://togogenome.org/gene/59894:SNX25 ^@ http://purl.uniprot.org/uniprot/U3KBH3 ^@ Similarity ^@ Belongs to the sorting nexin family. http://togogenome.org/gene/59894:USP20 ^@ http://purl.uniprot.org/uniprot/U3JFE6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the peptidase C19 family. USP20/USP33 subfamily.|||centrosome|||perinuclear region http://togogenome.org/gene/59894:ITM2B ^@ http://purl.uniprot.org/uniprot/A0A803W685 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ITM2 family.|||Membrane http://togogenome.org/gene/59894:TPT1 ^@ http://purl.uniprot.org/uniprot/U3K0H1 ^@ Similarity ^@ Belongs to the TCTP family. http://togogenome.org/gene/59894:TSHR ^@ http://purl.uniprot.org/uniprot/A0A803V609|||http://purl.uniprot.org/uniprot/A0A803VBU8|||http://purl.uniprot.org/uniprot/A0A803VL14 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Basolateral cell membrane|||Belongs to the G-protein coupled receptor 1 family. FSH/LSH/TSH subfamily.|||Cell membrane|||Membrane|||Receptor for the thyroid-stimulating hormone (TSH) or thyrotropin. Also acts as a receptor for the heterodimeric glycoprotein hormone (GPHA2:GPHB5) or thyrostimulin. The activity of this receptor is mediated by G proteins which activate adenylate cyclase. Plays a central role in controlling thyroid cell metabolism. http://togogenome.org/gene/59894:GALR3 ^@ http://purl.uniprot.org/uniprot/U3KE94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family.|||Membrane http://togogenome.org/gene/59894:OTC ^@ http://purl.uniprot.org/uniprot/U3JFT8|||http://purl.uniprot.org/uniprot/U3JFU0 ^@ Similarity|||Subunit ^@ Belongs to the aspartate/ornithine carbamoyltransferase superfamily.|||Homotrimer. http://togogenome.org/gene/59894:NTN4 ^@ http://purl.uniprot.org/uniprot/U3K8A7 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:FAN1 ^@ http://purl.uniprot.org/uniprot/U3KDG8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the FAN1 family.|||Nuclease required for the repair of DNA interstrand cross-links (ICL). Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flanking incisions.|||Nucleus http://togogenome.org/gene/59894:NIPAL3 ^@ http://purl.uniprot.org/uniprot/A0A803W2U1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the NIPA family.|||Membrane http://togogenome.org/gene/59894:CHGA ^@ http://purl.uniprot.org/uniprot/U3JID6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the chromogranin/secretogranin protein family.|||Secreted http://togogenome.org/gene/59894:VSNL1 ^@ http://purl.uniprot.org/uniprot/A0A803VTJ8 ^@ Function ^@ Regulates (in vitro) the inhibition of rhodopsin phosphorylation in a calcium-dependent manner. http://togogenome.org/gene/59894:TBCE ^@ http://purl.uniprot.org/uniprot/U3KGH6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the TBCE family.|||Cytoplasm http://togogenome.org/gene/59894:AXIN1 ^@ http://purl.uniprot.org/uniprot/U3JND6 ^@ Subcellular Location Annotation ^@ Cell membrane|||Cytoplasm|||Membrane|||Nucleus http://togogenome.org/gene/59894:NFASC ^@ http://purl.uniprot.org/uniprot/U3JC94 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the immunoglobulin superfamily. L1/neurofascin/NgCAM family.|||Membrane http://togogenome.org/gene/59894:GOLT1A ^@ http://purl.uniprot.org/uniprot/U3JCE8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the GOT1 family.|||Golgi apparatus membrane|||May be involved in fusion of ER-derived transport vesicles with the Golgi complex.|||Membrane http://togogenome.org/gene/59894:SNAP23 ^@ http://purl.uniprot.org/uniprot/U3JSX7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SNAP-25 family.|||synaptosome http://togogenome.org/gene/59894:PTPN14 ^@ http://purl.uniprot.org/uniprot/U3KCV6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the protein-tyrosine phosphatase family. Non-receptor class subfamily.|||cytoskeleton http://togogenome.org/gene/59894:LOC101817365 ^@ http://purl.uniprot.org/uniprot/U3KI83 ^@ Similarity|||Subunit ^@ Belongs to the avian keratin family.|||The avian keratins (F-ker, S-ker, C-ker and B-ker) are a complex mixture of very similar polypeptides. http://togogenome.org/gene/59894:GGNBP2 ^@ http://purl.uniprot.org/uniprot/U3JS00|||http://purl.uniprot.org/uniprot/U3JS03 ^@ Function ^@ May be involved in spermatogenesis. http://togogenome.org/gene/59894:ZDHHC8 ^@ http://purl.uniprot.org/uniprot/A0A803VVT5 ^@ Domain|||Similarity|||Subcellular Location Annotation ^@ Belongs to the DHHC palmitoyltransferase family. ERF2/ZDHHC9 subfamily.|||Golgi apparatus membrane|||Membrane|||The DHHC domain is required for palmitoyltransferase activity. http://togogenome.org/gene/59894:AKAP12 ^@ http://purl.uniprot.org/uniprot/U3KCN0 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:MALL ^@ http://purl.uniprot.org/uniprot/U3KA77 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:NAT1 ^@ http://purl.uniprot.org/uniprot/U3KIP5 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/59894:TPM1 ^@ http://purl.uniprot.org/uniprot/A0A803VWQ6|||http://purl.uniprot.org/uniprot/A0A803W6L2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the tropomyosin family.|||cytoskeleton http://togogenome.org/gene/59894:PIK3C2A ^@ http://purl.uniprot.org/uniprot/U3JDF0 ^@ Similarity ^@ Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. http://togogenome.org/gene/59894:LOC101815283 ^@ http://purl.uniprot.org/uniprot/U3K2P0 ^@ Function|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the UQCRQ/QCR8 family.|||Component of the ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII), a multisubunit enzyme composed of 11 subunits. The complex is composed of 3 respiratory subunits cytochrome b, cytochrome c1 and Rieske protein UQCRFS1, 2 core protein subunits UQCRC1/QCR1 and UQCRC2/QCR2, and 6 low-molecular weight protein subunits UQCRH/QCR6, UQCRB/QCR7, UQCRQ/QCR8, UQCR10/QCR9, UQCR11/QCR10 and subunit 9, the cleavage product of Rieske protein UQCRFS1. The complex exists as an obligatory dimer and forms supercomplexes (SCs) in the inner mitochondrial membrane with NADH-ubiquinone oxidoreductase (complex I, CI) and cytochrome c oxidase (complex IV, CIV), resulting in different assemblies (supercomplex SCI(1)III(2)IV(1) and megacomplex MCI(2)III(2)IV(2)). Interacts with BRAWNIN.|||Component of the ubiquinol-cytochrome c oxidoreductase, a multisubunit transmembrane complex that is part of the mitochondrial electron transport chain which drives oxidative phosphorylation. The respiratory chain contains 3 multisubunit complexes succinate dehydrogenase (complex II, CII), ubiquinol-cytochrome c oxidoreductase (cytochrome b-c1 complex, complex III, CIII) and cytochrome c oxidase (complex IV, CIV), that cooperate to transfer electrons derived from NADH and succinate to molecular oxygen, creating an electrochemical gradient over the inner membrane that drives transmembrane transport and the ATP synthase. The cytochrome b-c1 complex catalyzes electron transfer from ubiquinol to cytochrome c, linking this redox reaction to translocation of protons across the mitochondrial inner membrane, with protons being carried across the membrane as hydrogens on the quinol. In the process called Q cycle, 2 protons are consumed from the matrix, 4 protons are released into the intermembrane space and 2 electrons are passed to cytochrome c.|||Membrane|||Mitochondrion inner membrane http://togogenome.org/gene/59894:LOC101805628 ^@ http://purl.uniprot.org/uniprot/U3JCA0 ^@ Similarity ^@ Belongs to the peptidase M10A family. http://togogenome.org/gene/59894:KCNB1 ^@ http://purl.uniprot.org/uniprot/A0A803VWE7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the potassium channel family. B (Shab) (TC 1.A.1.2) subfamily. Kv2.1/KCNB1 sub-subfamily.|||Lateral cell membrane|||Membrane|||Perikaryon|||Postsynaptic cell membrane|||Synaptic cell membrane|||axon|||sarcolemma|||synaptosome http://togogenome.org/gene/59894:FAM189A2 ^@ http://purl.uniprot.org/uniprot/U3JQB1 ^@ Similarity ^@ Belongs to the ENTREP family. http://togogenome.org/gene/59894:SLC17A6 ^@ http://purl.uniprot.org/uniprot/U3JQB8 ^@ Subcellular Location Annotation ^@ Membrane http://togogenome.org/gene/59894:H3F3B ^@ http://purl.uniprot.org/uniprot/U3JE91 ^@ Similarity|||Subunit ^@ Belongs to the histone H3 family.|||The nucleosome is a histone octamer containing two molecules each of H2A, H2B, H3 and H4 assembled in one H3-H4 heterotetramer and two H2A-H2B heterodimers. The octamer wraps approximately 147 bp of DNA. http://togogenome.org/gene/59894:RWDD3 ^@ http://purl.uniprot.org/uniprot/A0A803VNH8 ^@ Subcellular Location Annotation ^@ Cytoplasm|||Nucleus http://togogenome.org/gene/59894:SLC25A21 ^@ http://purl.uniprot.org/uniprot/U3JUG5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the mitochondrial carrier (TC 2.A.29) family.|||Membrane http://togogenome.org/gene/59894:RHO ^@ http://purl.uniprot.org/uniprot/U3KGW6 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 1 family. Opsin subfamily.|||Membrane http://togogenome.org/gene/59894:TFAP2D ^@ http://purl.uniprot.org/uniprot/U3KE72 ^@ Similarity ^@ Belongs to the AP-2 family. http://togogenome.org/gene/59894:DTNA ^@ http://purl.uniprot.org/uniprot/U3JTK7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the dystrophin family. Dystrobrevin subfamily.|||Cytoplasm http://togogenome.org/gene/59894:MAP4K3 ^@ http://purl.uniprot.org/uniprot/A0A803WA67 ^@ Function|||Similarity ^@ Belongs to the protein kinase superfamily. STE Ser/Thr protein kinase family. STE20 subfamily.|||May play a role in the response to environmental stress. Appears to act upstream of the JUN N-terminal pathway. http://togogenome.org/gene/59894:PGAP3 ^@ http://purl.uniprot.org/uniprot/U3JCP6 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the PGAP3 family.|||Golgi apparatus membrane|||Involved in the lipid remodeling steps of GPI-anchor maturation.|||Membrane http://togogenome.org/gene/59894:TSHZ2 ^@ http://purl.uniprot.org/uniprot/A0A803V9D1 ^@ Similarity ^@ Belongs to the teashirt C2H2-type zinc-finger protein family. http://togogenome.org/gene/59894:LOC101818100 ^@ http://purl.uniprot.org/uniprot/U3K7C5 ^@ Similarity ^@ Belongs to the cytochrome P450 family. http://togogenome.org/gene/59894:DERL2 ^@ http://purl.uniprot.org/uniprot/U3K5A7 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the derlin family.|||Endoplasmic reticulum membrane|||Functional component of endoplasmic reticulum-associated degradation (ERAD) for misfolded lumenal proteins. May act by forming a channel that allows the retrotranslocation of misfolded proteins into the cytosol where they are ubiquitinated and degraded by the proteasome.|||Membrane http://togogenome.org/gene/59894:ABCC8 ^@ http://purl.uniprot.org/uniprot/U3JDE3 ^@ Subunit ^@ Interacts with KCNJ11. http://togogenome.org/gene/59894:AMDHD2 ^@ http://purl.uniprot.org/uniprot/U3JQK5 ^@ Cofactor|||Similarity ^@ Belongs to the metallo-dependent hydrolases superfamily. NagA family.|||Binds 1 divalent metal cation per subunit. http://togogenome.org/gene/59894:TMEM97 ^@ http://purl.uniprot.org/uniprot/A0A803WAS2 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the TMEM97/sigma-2 receptor family.|||Endoplasmic reticulum membrane|||Intracellular orphan receptor that binds numerous drugs and which is highly expressed in various proliferating cells. Corresponds to the sigma-2 receptor, which is thought to play important role in regulating cell survival, morphology and differentiation. May play a role as a regulator of cellular cholesterol homeostasis. May function as sterol isomerase. May alter the activity of some cytochrome P450 proteins.|||Membrane|||Nucleus membrane|||Rough endoplasmic reticulum membrane http://togogenome.org/gene/59894:TM4SF4 ^@ http://purl.uniprot.org/uniprot/U3JRX5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the L6 tetraspanin family.|||Membrane http://togogenome.org/gene/59894:SLC13A5 ^@ http://purl.uniprot.org/uniprot/U3JQ09 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SLC13A/DASS transporter (TC 2.A.47) family. NADC subfamily.|||Membrane http://togogenome.org/gene/59894:PPAT ^@ http://purl.uniprot.org/uniprot/A0A803VDM4 ^@ Cofactor|||Similarity ^@ Binds 1 Mg(2+) ion per subunit.|||Binds 1 [4Fe-4S] cluster per subunit.|||In the C-terminal section; belongs to the purine/pyrimidine phosphoribosyltransferase family. http://togogenome.org/gene/59894:SKA2 ^@ http://purl.uniprot.org/uniprot/U3JSV3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SKA2 family.|||spindle http://togogenome.org/gene/59894:SPATS2L ^@ http://purl.uniprot.org/uniprot/A0A803V2K8|||http://purl.uniprot.org/uniprot/A0A803VLP4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPATS2 family.|||Cytoplasm http://togogenome.org/gene/59894:SLC41A3 ^@ http://purl.uniprot.org/uniprot/A0A803VAU5|||http://purl.uniprot.org/uniprot/U3JHA9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Acts as a magnesium transporter.|||Belongs to the SLC41A transporter family.|||Membrane http://togogenome.org/gene/59894:LOC101814452 ^@ http://purl.uniprot.org/uniprot/U3JRA1 ^@ Similarity ^@ Belongs to the peptidase M14 family. http://togogenome.org/gene/59894:RPLP2 ^@ http://purl.uniprot.org/uniprot/U3K7C4 ^@ Function|||Similarity|||Subunit ^@ Belongs to the eukaryotic ribosomal protein P1/P2 family.|||Heterodimer with RPLP1 at the lateral ribosomal stalk of the large ribosomal subunit.|||Plays an important role in the elongation step of protein synthesis. http://togogenome.org/gene/59894:ORAI1 ^@ http://purl.uniprot.org/uniprot/A0A803V3S4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the Orai family.|||Membrane http://togogenome.org/gene/59894:GPR158 ^@ http://purl.uniprot.org/uniprot/U3JXR1 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 3 family.|||Cell membrane|||Membrane http://togogenome.org/gene/59894:UTP18 ^@ http://purl.uniprot.org/uniprot/U3JFB3 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the WD repeat UTP18 family.|||nucleolus http://togogenome.org/gene/59894:LOC101810753 ^@ http://purl.uniprot.org/uniprot/U3KIP8 ^@ Similarity ^@ Belongs to the arylamine N-acetyltransferase family. http://togogenome.org/gene/59894:MTFR1L ^@ http://purl.uniprot.org/uniprot/A0A803VSK8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the MTFR1 family.|||Mitochondrion|||Plays a role in mitochondrial aerobic respiration. Regulates mitochondrial organization and fission. http://togogenome.org/gene/59894:TMPRSS2 ^@ http://purl.uniprot.org/uniprot/U3JHB8 ^@ Caution ^@ Lacks conserved residue(s) required for the propagation of feature annotation. http://togogenome.org/gene/59894:ZNF488 ^@ http://purl.uniprot.org/uniprot/A0A803WE74 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:CKMT2 ^@ http://purl.uniprot.org/uniprot/U3KE71|||http://purl.uniprot.org/uniprot/U3KE73 ^@ Similarity ^@ Belongs to the ATP:guanido phosphotransferase family. http://togogenome.org/gene/59894:CTPS1 ^@ http://purl.uniprot.org/uniprot/U3JEH3 ^@ Function|||Similarity ^@ Belongs to the CTP synthase family.|||Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. http://togogenome.org/gene/59894:CTNNA1 ^@ http://purl.uniprot.org/uniprot/A0A803VZ92|||http://purl.uniprot.org/uniprot/U3JKC7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the vinculin/alpha-catenin family.|||Cell membrane|||Membrane|||adherens junction|||cytoskeleton http://togogenome.org/gene/59894:EXT2 ^@ http://purl.uniprot.org/uniprot/U3KCU5 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 47 family.|||Endoplasmic reticulum membrane http://togogenome.org/gene/59894:USP44 ^@ http://purl.uniprot.org/uniprot/U3K8A2 ^@ Similarity ^@ Belongs to the peptidase C19 family. http://togogenome.org/gene/59894:C5H14orf159 ^@ http://purl.uniprot.org/uniprot/A0A803V2Q3|||http://purl.uniprot.org/uniprot/U3KCE7 ^@ Similarity ^@ Belongs to the D-glutamate cyclase family. http://togogenome.org/gene/59894:NKAIN1 ^@ http://purl.uniprot.org/uniprot/U3JEN6 ^@ Caution|||Similarity|||Subcellular Location Annotation ^@ Belongs to the NKAIN family.|||Cell membrane|||Lacks conserved residue(s) required for the propagation of feature annotation.|||Membrane http://togogenome.org/gene/59894:ANO6 ^@ http://purl.uniprot.org/uniprot/U3K6E4 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the anoctamin family.|||Membrane http://togogenome.org/gene/59894:LOC101821224 ^@ http://purl.uniprot.org/uniprot/U3KL46 ^@ Similarity ^@ Belongs to the G-protein coupled receptor 1 family. http://togogenome.org/gene/59894:FOXI1 ^@ http://purl.uniprot.org/uniprot/U3K4K9 ^@ Subcellular Location Annotation ^@ Nucleus http://togogenome.org/gene/59894:ST3GAL5 ^@ http://purl.uniprot.org/uniprot/U3K656 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the glycosyltransferase 29 family.|||Membrane http://togogenome.org/gene/59894:ODF2 ^@ http://purl.uniprot.org/uniprot/U3JFA7 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ODF2 family.|||centrosome http://togogenome.org/gene/59894:GTF2B ^@ http://purl.uniprot.org/uniprot/U3JFZ7 ^@ Similarity ^@ Belongs to the TFIIB family. http://togogenome.org/gene/59894:GALNS ^@ http://purl.uniprot.org/uniprot/A0A803VAP0|||http://purl.uniprot.org/uniprot/U3JL38 ^@ PTM|||Similarity|||Subcellular Location Annotation|||Subunit ^@ Belongs to the sulfatase family.|||Homodimer.|||Lysosome|||The conversion to 3-oxoalanine (also known as C-formylglycine, FGly), of a serine or cysteine residue in prokaryotes and of a cysteine residue in eukaryotes, is critical for catalytic activity. http://togogenome.org/gene/59894:CMC2 ^@ http://purl.uniprot.org/uniprot/A0A803VTK2 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CMC family.|||Mitochondrion http://togogenome.org/gene/59894:ADGRA1 ^@ http://purl.uniprot.org/uniprot/U3K009 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the G-protein coupled receptor 2 family. Adhesion G-protein coupled receptor (ADGR) subfamily.|||Membrane http://togogenome.org/gene/59894:NXPE3 ^@ http://purl.uniprot.org/uniprot/A0A803V7A0 ^@ Similarity ^@ Belongs to the NXPE family. http://togogenome.org/gene/59894:GGT7 ^@ http://purl.uniprot.org/uniprot/A0A803VK00 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the gamma-glutamyltransferase family.|||Cleaves the gamma-glutamyl peptide bond of glutathione and glutathione conjugates.|||Membrane http://togogenome.org/gene/59894:LAMC3 ^@ http://purl.uniprot.org/uniprot/U3JFF7 ^@ Caution|||Subcellular Location Annotation ^@ Lacks conserved residue(s) required for the propagation of feature annotation.|||basement membrane http://togogenome.org/gene/59894:SPSB4 ^@ http://purl.uniprot.org/uniprot/U3JW04 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the SPSB family.|||Cytoplasm http://togogenome.org/gene/59894:PTRF ^@ http://purl.uniprot.org/uniprot/U3JD45 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the CAVIN family.|||caveola http://togogenome.org/gene/59894:NDUFA8 ^@ http://purl.uniprot.org/uniprot/A0A803V4M4|||http://purl.uniprot.org/uniprot/U3JGU9 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Accessory subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I), that is believed not to be involved in catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone.|||Belongs to the complex I NDUFA8 subunit family.|||Mitochondrion inner membrane|||Mitochondrion intermembrane space http://togogenome.org/gene/59894:SLC34A2 ^@ http://purl.uniprot.org/uniprot/U3K3G8 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Apical cell membrane|||Belongs to the SLC34A transporter family.|||Cell membrane|||Involved in actively transporting phosphate into cells via Na(+) cotransport.|||Membrane http://togogenome.org/gene/59894:CRYAA ^@ http://purl.uniprot.org/uniprot/U3JH28 ^@ Function|||Similarity|||Subcellular Location Annotation ^@ Belongs to the small heat shock protein (HSP20) family.|||Contributes to the transparency and refractive index of the lens. May act as a chaperone, preventing aggregation of various proteins under a wide range of stress conditions.|||Cytoplasm http://togogenome.org/gene/59894:RHBG ^@ http://purl.uniprot.org/uniprot/U3JL67 ^@ Similarity|||Subcellular Location Annotation ^@ Belongs to the ammonium transporter (TC 2.A.49) family. Rh subfamily.|||Membrane